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Nodes: 246
Authors: 958,
Journals: 112,
Outer References: 9412
Collection span: 2002 - 2004
View: Overview. Sorted by GCS.
Page 1: 1 (281) 2 (4) 3 (0)
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 1 | 91 | 53 2002 SCIENCE 297(5580):353-356 Hardy J; Selkoe DJ Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics | 41 | 281 |
| 2 | 0 | 30 | 32 2002 NATURE 416(6880):535-539 Walsh DM; Klyubin I; Fadeeva JV; Cullen WK; Anwyl R; Wolfe MS; Rowan MJ; Selkoe DJ Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo | 245 | 255 |
| 3 | 1 | 74 | 52 2002 SCIENCE 296(5575):1991-1995 Taylor JP; Hardy J; Fischbeck KH Biomedicine - Toxic proteins in neurodegenerative disease | 9 | 105 |
| 4 | 1 | 34 | 54 2002 SCIENCE 298(5594):789-791 Selkoe DJ Alzheimer's disease is a synaptic failure | 21 | 98 |
| 5 | 1 | 13 | 33 2002 NATURE 418(6895):291-291 Lashuel HA; Hartley D; Petre BM; Walz T; Lansbury PT Neurodegenerative disease - Amyloid pores from pathogenic mutations | 20 | 93 |
| 6 | 1 | 49 | 49 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(13):8666-8671 Edbauer D; Winkler E; Haass C; Steiner H Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation | 3 | 69 |
| 7 | 2 | 148 | 135 2003 NATURE REVIEWS NEUROSCIENCE 4(1):49-60 Soto C Unfolding the role of protein misfolding in neurodegenerative diseases | 3 | 42 |
| 8 | 2 | 28 | 167 2003 SCIENCE 299(5607):713-716 Hammarstrom P; Wiseman RL; Powers ET; Kelly JW Prevention of transthyretin amyloid disease by changing protein misfolding energetics | 6 | 42 |
| 9 | 1 | 36 | 35 2002 NATURE MEDICINE 8(11):1263-1269 McLaurin J; Cecal R; Kierstead ME; Tian X; Phinney AL; Manea M; French JE; Lambermon MHL; Darabie AA; Brown ME; Janus C; Chishti MA; Horne P; Westaway D; Fraser PE; Mount HTJ; Przybylski M; St George-Hyslop P Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis | 5 | 40 |
| 10 | 1 | 39 | 44 2002 NEURON 34(6):905-919 Watase K; Weeber EJ; Xu BS; Antalffy B; Yuva-Paylor L; Hashimoto K; Kano M; Atkinson R; Sun YL; Armstrong DL; Sweatt JD; Orr HT; Paylor R; Zoghbi HY A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration | 5 | 39 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 11 | 1 | 69 | 13 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(35):32046-32053 Dahlgren KN; Manelli AM; Stine WB; Baker LK; Krafft GA; LaDu MJ Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability | 24 | 37 |
| 12 | 1 | 30 | 36 2002 NATURE MEDICINE 8(11):1270-1275 Hock C; Konietzko U; Papassotiropoulos A; Wollmer A; Streffer J; von Rotz RC; Davey G; Moritz E; Nitsch RM Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease | 5 | 37 |
| 13 | 1 | 50 | 143 2003 NEURON 37(6):911-924 Yang YF; Nishimura I; Imai Y; Takahashi R; Lu BW Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila | 2 | 37 |
| 14 | 4 | 48 | 145 2003 NEURON 39(3):409-421 Oddo S; Caccamo A; Shepherd JD; Murphy MP; Golde TE; Kayed R; Metherate R; Mattson MP; Akbari Y; LaFerla FM Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular A beta and synaptic dysfunction | 6 | 34 |
| 15 | 1 | 64 | 9 2002 FREE RADICAL RESEARCH 36(12):1307-1313 Butterfield DA Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer's disease brain. A review | 2 | 32 |
| 16 | 1 | 23 | 45 2002 NEURON 35(1):9-12 Muchowskil PJ Protein misfolding, amyloid formation, and neurodegeneration: A critical role for molecular chaperones? | 4 | 32 |
| 17 | 6 | 199 | 59 2003 ANNUAL REVIEW OF NEUROSCIENCE 26:267-298 Caughey B; Lansbury PT Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders | 7 | 31 |
| 18 | 2 | 66 | 144 2003 NEURON 37(6):925-937 Kamenetz F; Tomita T; Hsieh H; Seabrook G; Borchelt D; Iwatsubo T; Sisodia S; Malinow R APP processing and synaptic function | 9 | 31 |
| 19 | 1 | 78 | 173 2003 TRENDS IN NEUROSCIENCES 26(4):207-214 Bush AI The metallobiology of Alzheimer's disease | 1 | 31 |
| 20 | 1 | 154 | 23 2002 JOURNAL OF NEUROSCIENCE RESEARCH 69(5):567-577 Kirkitadze MD; Bitan G; Teplow DB Paradigm shifts in Alzheimer's disease and other neuro degenerative disorders: The emerging role of oligomeric assemblies | 10 | 29 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 21 | 1 | 150 | 61 2003 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 43:545-584 Selkoe DJ; Schenk D Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics | 7 | 29 |
| 22 | 1 | 35 | 16 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(43):41032-41037 Poirier MA; Li HL; Macosko J; Cai SW; Amzel M; Ross CA Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization | 8 | 27 |
| 23 | 1 | 10 | 31 2002 NATURE 416(6880):483-484 Ellis RJ; Pinheiro TJT Danger - misfolding proteins | 9 | 27 |
| 24 | 3 | 39 | 157 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(1):330-335 Bitan G; Kirkitadze MD; Lomakin A; Vollers SS; Benedek GB; Teplow DB Amyloid beta-protein (A beta) assembly: A beta 40 and A beta 42 oligomerize through distinct pathways | 15 | 27 |
| 25 | 3 | 96 | 38 2002 NATURE REVIEWS DRUG DISCOVERY 1(11):859-866 Wolfe MS Therapeutic strategies for Alzheimer's disease | 1 | 26 |
| 26 | 2 | 34 | 46 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99:16407-16411 Bonini NM Chaperoning brain degeneration | 4 | 26 |
| 27 | 1 | 37 | 142 2003 NEURON 37(4):583-595 Sharon R; Bar-Joseph I; Frosch MP; Walsh DM; Hamilton JA; Selkoe DJ The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease | 5 | 26 |
| 28 | 4 | 52 | 161 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(18):10417-10422 Gong YS; Chang L; Viola KL; Lacor PN; Lambert MP; Finch CE; Krafft GA; Klein WL Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss | 13 | 26 |
| 29 | 1 | 79 | 48 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99:16419-16426 Chiti F; Calamai M; Taddei N; Stefani M; Ramponi G; Dobson CM Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases | 4 | 23 |
| 30 | 1 | 155 | 3 2002 ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS 3:67-99 Selkoe DJ; Podlisny MB Deciphering the genetic basis of Alzheimer's disease | 2 | 22 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 31 | 1 | 65 | 20 2002 JOURNAL OF CLINICAL INVESTIGATION 110(10):1375-1381 Selkoe DJ Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease | 2 | 22 |
| 32 | 1 | 20 | 56 2002 STRUCTURE 10(8):1031-1036 Wetzel R Ideas of order for amyloid fibril structure | 2 | 22 |
| 33 | 1 | 83 | 22 2002 JOURNAL OF NEUROCHEMISTRY 83(3):481-489 Bahr BA; Bendiske J The neuropathogenic contributions of lysosomal dysfunction | 1 | 20 |
| 34 | 2 | 83 | 47 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99:16412-16418 Sakahira H; Breuer P; Hayer-Hartl MK; Hartl FU Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity | 4 | 20 |
| 35 | 1 | 28 | 50 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(20):13217-13221 Vitolo OV; Sant'Angelo A; Costanzo V; Battaglia F; Arancio O; Shelanski M Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling | 9 | 20 |
| 36 | 3 | 114 | 151 2003 NEW ENGLAND JOURNAL OF MEDICINE 349(6):583-596 Merlini G; Bellotti V Molecular mechanisms of amyloidosis | 1 | 20 |
| 37 | 2 | 68 | 10 2002 HUMAN MOLECULAR GENETICS 11(23):2895-2904 Chan HYE; Warrick JM; Andriola I; Merry D; Bonini NM Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila | 3 | 19 |
| 38 | 1 | 80 | 19 2002 JOURNAL OF CLINICAL INVESTIGATION 110(9):1221-1232 Horwich A Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions | 3 | 19 |
| 39 | 1 | 506 | 51 2002 PROGRESS IN NEUROBIOLOGY 68(3):209-245 Auld DS; Kornecook TJ; Bastianetto S; Quirion R Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies | 1 | 19 |
| 40 | 5 | 81 | 79 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(3):253-261 Berke SJS; Paulson HL Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration | 3 | 18 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 41 | 3 | 64 | 83 2003 EMBO JOURNAL 22(3):355-361 Temussi PA; Masino L; Pastore A From Alzheimer to Huntington: why is a structural understanding so difficult? | 1 | 16 |
| 42 | 5 | 74 | 86 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(13):11612-11622 Stine WB; Dahlgren KN; Krafft GA; LaDu MJ In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis | 7 | 16 |
| 43 | 1 | 25 | 117 2003 JOURNAL OF NEUROSCIENCE 23(6):1992-1996 Marr RA; Rockenstein E; Mukherjee A; Kindy MS; Hersh LB; Gage FH; Verma IM; Masliah E Neprilysin gene transfer reduces human amyloid pathology in transgenic mice | 1 | 16 |
| 44 | 8 | 71 | 130 2003 NATURE 426(6968):884-890 Dobson CM Protein folding and misfolding | 1 | 16 |
| 45 | 11 | 200 | 109 2003 JOURNAL OF MOLECULAR MEDICINE-JMM 81(11):678-699 Stefani M; Dobson CM Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution | 5 | 15 |
| 46 | 1 | 45 | 6 2002 EMBO JOURNAL 21(22):6005-6014 Sandilands A; Hutcheson AM; Long HA; Prescott AR; Vrensen G; Loster J; Klopp N; Lutz RB; Graw J; Masaki S; Dobson CM; MacPhee CE; Quinlan RA Altered aggregation properties of mutant gamma-crystallins cause inherited cataract | 3 | 13 |
| 47 | 4 | 87 | 81 2003 CURRENT OPINION IN STRUCTURAL BIOLOGY 13(2):146-159 Thirumalai D; Klimov DK; Dima RI Emerging ideas on the molecular basis of protein and peptide aggregation | 2 | 13 |
| 48 | 1 | 48 | 159 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(11):6370-6375 Hoshi M; Sato M; Matsumoto S; Noguchi A; Yasutake K; Yoshida N; Sato K Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3 beta | 3 | 13 |
| 49 | 1 | 48 | 15 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(43):40173-40176 Hou LM; Kang I; Marchant RE; Zagorski MG Methionine 35 oxidation reduces fibril assembly of the amyloid A beta-(1-42) peptide of Alzheimer's disease | 7 | 12 |
| 50 | 1 | 49 | 21 2002 JOURNAL OF MOLECULAR BIOLOGY 319(5):1279-1290 Wurth C; Guimard NK; Hecht MH Mutations that reduce aggregation of the Alzheimer's A beta 42 peptide: an unbiased search for the sequence determinants of A beta amyloidogenesis | 2 | 12 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 51 | 1 | 51 | 136 2003 NEUROBIOLOGY OF AGING 24(3):415-420 Drake J; Link CD; Butterfield DA Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model | 4 | 12 |
| 52 | 2 | 49 | 132 2003 NATURE 426(6968):905-909 Cohen FE; Kelly JW Therapeutic approaches to protein-misfolding diseases | 1 | 11 |
| 53 | 1 | 53 | 41 2002 NATURE STRUCTURAL BIOLOGY 9(5):323-325 Kelly JW Towards an understanding of amyloidogenesis | 2 | 10 |
| 54 | 2 | 60 | 99 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(44):42959-42965 Barnham KJ; Ciccotosto GD; Tickler AK; Ali FE; Smith DG; Williamson NA; Lam YH; Carrington D; Tew D; Kocak G; Volitakis I; Separovic F; Barrow CJ; Wade JD; Masters CL; Cherny RA; Curtain CC; Bush AI; Cappai R Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation | 4 | 10 |
| 55 | 1 | 47 | 107 2003 JOURNAL OF MOLECULAR BIOLOGY 325(4):743-757 Gorman PM; Yip CM; Fraser PE; Chakrabartty A Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: A beta association kinetics at endosomal pH | 1 | 10 |
| 56 | 5 | 402 | 148 2003 NEUROPHARMACOLOGY 45(1):14-44 Dev KK; Hofele K; Barbieri S; Buchman VL; van der Putten H Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease | 1 | 10 |
| 57 | 2 | 39 | 168 2003 STROKE 34(2):335-337 Iadecola C; Gorelick PB Converging pathogenic mechanisms in vascular and neurodegenerative dementia | 1 | 10 |
| 58 | 1 | 57 | 8 2002 FREE RADICAL BIOLOGY AND MEDICINE 33(9):1194-1199 Smith MA; Casadesus G; Joseph JA; Perry G Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain | 0 | 9 |
| 59 | 1 | 42 | 118 2003 JOURNAL OF NEUROSCIENCE 23(12):5219-5226 Dickey CA; Loring JF; Montgomery J; Gordon MN; Eastman PS; Morgan D Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein plus presenilin-1 transgenic mice | 2 | 9 |
| 60 | 1 | 95 | 127 2003 MOLECULAR BIOLOGY OF THE CELL 14(11):4541-4556 Ardley HC; Scott GB; Rose SA; Tan NGS; Markham AF; Robinson PA Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin | 1 | 9 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 61 | 4 | 26 | 131 2003 NATURE 426(6968):900-904 Selkoe DJ Folding proteins in fatal ways | 0 | 9 |
| 62 | 3 | 66 | 158 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(3):1381-1386 Redwine JM; Kosofsky B; Jacobs RE; Games D; Reilly JF; Morrison JH; Young WG; Bloom FE Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis | 1 | 9 |
| 63 | 1 | 55 | 14 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(36):33012-33017 Mohajeri MH; Saini K; Schultz JG; Wollmer MA; Hock C; Nitsch RM Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation | 1 | 8 |
| 64 | 1 | 241 | 43 2002 NEUROMOLECULAR MEDICINE 2(2):167-196 Chan SL; Furukawa K; Mattson MP Presenilins and APP in neuritic and synaptic plasticity - Implications for the pathogenesis of Alzheimer's disease | 0 | 8 |
| 65 | 5 | 63 | 108 2003 JOURNAL OF MOLECULAR BIOLOGY 332(4):795-808 Lashuel HA; Hartley DM; Petre BM; Wall JS; Simon MN; Walz T; Lansbury PT Mixtures of wild-type and a pathogenic (E22G) form of A beta 40 in vitro accumulate protofibrils, including amyloid pores | 4 | 8 |
| 66 | 1 | 25 | 174 2003 TRENDS IN NEUROSCIENCES 26(8):407-410 Forman MS; Lee VMY; Trojanowski JQ 'Unfolding' pathways in neurodegenerative disease | 0 | 8 |
| 67 | 1 | 49 | 1 2002 AMERICAN JOURNAL OF PATHOLOGY 161(5):1935-1948 Sousa MM; Fernandes R; Palha JA; Taboada A; Vieira P; Saraiva MJ Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro | 2 | 7 |
| 68 | 3 | 15 | 34 2002 NATURE MEDICINE 8(11):1195-1196 Haass C New hope for Alzheimer disease vaccine | 1 | 7 |
| 69 | 2 | 217 | 126 2003 MASS SPECTROMETRY REVIEWS 22(1):1-26 Konermann L; Simmons DA Protein-folding kinetics and mechanisms studied by pulse-labeling and mass spectrometry | 0 | 7 |
| 70 | 1 | 26 | 11 2002 HUMAN MOLECULAR GENETICS 11(25):3209-3219 Deery EC; Vithana EN; Newbold RJ; Gallon VA; Bhattacharya SS; Warren MJ; Hunt DM; Wilkie SE Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31 | 0 | 6 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 71 | 1 | 65 | 17 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(45):42881-42890 Lashuel HA; Hartley DM; Balakhaneh D; Aggarwal A; Teichberg S; Callaway DJE New class of inhibitors of amyloid-beta fibril formation - Implications for the mechanism of pathogenesis in Alzheimer's disease | 1 | 6 |
| 72 | 1 | 188 | 29 2002 MOLECULAR NEUROBIOLOGY 26(2-3):299-316 Echeverria V; Cuello AC Intracellular A-beta amyloid, a sign for worse things to come? | 0 | 6 |
| 73 | 1 | 15 | 133 2003 NATURE GENETICS 34(2):151-153 Levy-Nissenbaum E; Betz RC; Frydman M; Simon M; Lahat H; Bakhan T; Goldman B; Bygum A; Pierick M; Hillmer AM; Jonca N; Toribio J; Kruse R; Dewald G; Cichon S; Kubisch C; Guerrin M; Serre G; Nothen MM; Pras E Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin | 0 | 6 |
| 74 | 7 | 41 | 146 2003 NEURON 40(6):1087-1093 Leissring MA; Farris W; Chang AY; Walsh DM; Wu XN; Sun XY; Frosch MP; Selkoe DJ Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death | 1 | 6 |
| 75 | 3 | 290 | 162 2003 PROGRESS IN NEUROBIOLOGY 70(1):1-32 Turner PR; O'Connor K; Tate WP; Abraham WC Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory | 1 | 6 |
| 76 | 1 | 50 | 165 2003 PROTEINS-STRUCTURE FUNCTION AND GENETICS 51(1):147-153 Vaiana SM; Palma-Vittorelli MB; Palma MU Time scale of protein aggregation dictated by liquid-liquid demixing | 1 | 6 |
| 77 | 2 | 60 | 72 2003 BIOESSAYS 25(3):283-288 Robinson SR; Bishop GM; Munch G Alzheimer vaccine: amyloid-beta on trial | 2 | 5 |
| 78 | 5 | 308 | 85 2003 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 35(11):1505-1535 Ling Y; Morgan K; Kalsheker N Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease | 3 | 5 |
| 79 | 2 | 70 | 87 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(15):13047-13055 Nucifora FC; Ellerby LM; Wellington CL; Wood JD; Herring WJ; Sawa A; Hayden MR; Dawson VL; Dawson TM; Ross CA Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity | 0 | 5 |
| 80 | 5 | 67 | 94 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(37):34882-34889 Bitan G; Vollers SS; Teplow DB Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization | 2 | 5 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 81 | 2 | 29 | 110 2003 JOURNAL OF MOLECULAR NEUROSCIENCE 20(3):305-313 Chang L; Bakhos L; Wang ZQ; Venton DL; Klein WL Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening | 4 | 5 |
| 82 | 1 | 52 | 160 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(14):8182-8187 Dickerson TJ; Janda KD Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease | 1 | 5 |
| 83 | 1 | 34 | 172 2003 TRENDS IN NEUROSCIENCES 26(1):4-7 Ehlers MD Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease | 0 | 5 |
| 84 | 1 | 34 | 4 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 296(5):1317-1321 Rovira C; Arbez N; Mariani J A beta(25-35) and A beta(1-40) act on different calcium channels in CA1 hippocampal neurons | 0 | 4 |
| 85 | 3 | 79 | 68 2003 BIOCHEMISTRY 42(36):10863-10873 Cottingham MG; Voskuil JLA; Vaux DJT The intact human acetylcholinesterase C-terminal oligomerization domain is alpha-helical in situ and in isolation, but a shorter fragment forms beta-sheet-rich amyloid fibrils and protofibrillar oligomers | 0 | 4 |
| 86 | 9 | 76 | 70 2003 BIOCHEMISTRY 42(44):12749-12760 Chromy BA; Nowak RJ; Lambert MP; Viola KL; Chang L; Velasco PT; Jones BW; Fernandez SJ; Lacor PN; Horowitz P; Finch CE; Krafft GA; Klein WL Self-assembly of A beta(1-42) into globular neurotoxins | 1 | 4 |
| 87 | 1 | 37 | 74 2003 BRAIN RESEARCH 968(2):263-272 Raymond CR; Ireland DR; Abraham WC NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus | 4 | 4 |
| 88 | 5 | 137 | 77 2003 CNS DRUGS 17(9):641-652 Butterfield DA; Pocernich CB The glutamatergic system and Alzheimer's disease - Therapeutic implications | 0 | 4 |
| 89 | 1 | 53 | 89 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(26):23221-23226 Morelli L; Llovera R; Gonzalez SA; Affranchino JL; Prelli F; Frangione B; Ghiso J; Castano EM Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme | 3 | 4 |
| 90 | 2 | 58 | 91 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(30):27971-27980 Minogue AM; Schmid AW; Fogarty MP; Moore AC; Campbell VA; Herron CE; Lynch MA Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus - A role for interleukin-1 beta? | 0 | 4 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 91 | 2 | 47 | 97 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(42):41452-41461 Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin - A potential mechanism for loss of huntingtin function in Huntington's disease | 0 | 4 |
| 92 | 1 | 61 | 105 2003 JOURNAL OF COMPARATIVE NEUROLOGY 462(4):371-381 German DC; Yazdani U; Speciale SG; Pasbakish P; Games D; Liang CL Cholinergic neuropathology in a mouse model of Alzheimer's disease | 0 | 4 |
| 93 | 2 | 74 | 106 2003 JOURNAL OF LIPID RESEARCH 44(8):1423-1430 Raffai RL; Weisgraber KH Cholesterol: from heart attacks to Alzheimer's disease | 0 | 4 |
| 94 | 3 | 38 | 113 2003 JOURNAL OF NEUROCHEMISTRY 85(6):1581-1591 Sergeant N; Bombois S; Ghestem A; Drobecq H; Kostanjevecki V; Missiaen C; Wattez A; David JP; Vanmechelen E; Sergheraert C; Delacourte A Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach | 1 | 4 |
| 95 | 7 | 66 | 122 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(50):15359-15365 Bitan G; Tarus B; Vollers SS; Lashuel HA; Condron MM; Straub JE; Teplow DB A molecular switch in amyloid assembly: Met(35) and amyloid beta-protein oligomerization | 2 | 4 |
| 96 | 2 | 51 | 123 2003 JOURNAL OF VIROLOGY 77(13):7611-7622 Chiesa R; Piccardo P; Quaglio E; Drisaldi B; Si-Hoe SL; Takao M; Ghetti B; Harris DA Molecular distinction between pathogenic and infectious properties of the prion protein | 0 | 4 |
| 97 | 1 | 58 | 125 2003 LANCET NEUROLOGY 2(8):506-511 Silverberg GD; Mayo M; Saul T; Rubenstein E; McGuire D Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis | 1 | 4 |
| 98 | 1 | 37 | 137 2003 NEUROBIOLOGY OF DISEASE 13(3):177-190 Ye CP; Selkoe DJ; Hartley DM Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures | 3 | 4 |
| 99 | 1 | 201 | 153 2003 PHARMACOLOGY & THERAPEUTICS 97(1):35-53 Kitamura Y; Nomura Y Stress proteins and glial functions: possible therapeutic targets for neurodegenerative disorders | 0 | 4 |
| 100 | 2 | 65 | 154 2003 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 361(1807):1205-1222 Vendruscolo M; Zurdo J; MacPhee CE; Dobson CM Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems | 2 | 4 |
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