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Tue Aug 31 16:33:14 2004
Naturally secreted oligomers of amyloid beta protein potently
inhibit hippocampal long-term potentiation in vivo

Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R,
Wolfe MS, Rowan MJ, Selkoe DJ
NATURE 416 (6880): 535-539 APR 4 2002
and the citing papers

Nodes: 246
Authors: 958, Journals: 112, Outer References: 9412
Collection span: 2002 - 2004
View: Overview. Sorted by year, source, volume, issue, page.
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#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
101156101 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(49):48644-48650
Devlin GL; Carver JA; Bottomley SP
The selective inhibition of serpin aggregation by the molecular chaperone, alpha-crystallin, indicates a nucleation-dependent specificity
01
102142102 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(51):51035-51043
Chyung JH; Selkoe DJ
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface
01
103247103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(51):51770-51778
Laurine E; Gregoire C; Fandrich M; Engemann S; Marchal S; Thion L; Mohr M; Monsarrat B; Michel B; Dobson CM; Wanker E; Erard M; Verdier JM
Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease
11
104334104 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(52):52519-52523
Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; Steiner H; Haass C
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
02
105161105 2003 JOURNAL OF COMPARATIVE NEUROLOGY 462(4):371-381
German DC; Yazdani U; Speciale SG; Pasbakish P; Games D; Liang CL
Cholinergic neuropathology in a mouse model of Alzheimer's disease
04
106274106 2003 JOURNAL OF LIPID RESEARCH 44(8):1423-1430
Raffai RL; Weisgraber KH
Cholesterol: from heart attacks to Alzheimer's disease
04
107147107 2003 JOURNAL OF MOLECULAR BIOLOGY 325(4):743-757
Gorman PM; Yip CM; Fraser PE; Chakrabartty A
Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: A beta association kinetics at endosomal pH
110
108563108 2003 JOURNAL OF MOLECULAR BIOLOGY 332(4):795-808
Lashuel HA; Hartley DM; Petre BM; Wall JS; Simon MN; Walz T; Lansbury PT
Mixtures of wild-type and a pathogenic (E22G) form of A beta 40 in vitro accumulate protofibrils, including amyloid pores
48
10911200109 2003 JOURNAL OF MOLECULAR MEDICINE-JMM 81(11):678-699
Stefani M; Dobson CM
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
515
110229110 2003 JOURNAL OF MOLECULAR NEUROSCIENCE 20(3):305-313
Chang L; Bakhos L; Wang ZQ; Venton DL; Klein WL
Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening
45
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
111220111 2003 JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 666:537-545
Almeida DRP; Gasparro DM; Pisterzi LF; Juhasz JR; Fulop F; Csizmadia IG
Predicting the conformations of carvedilol based on its pharmacophore fragments: a gas phase and solvation ab initio and density functional study
11
112151112 2003 JOURNAL OF NEURAL TRANSMISSION 110(11):1313-1327
Rockenstein E; Adame A; Mante M; Moessler H; Windisch M; Masliah E
The neuroprotective effects of Cerebrolysin (TM) in a transgenic model of Alzheimer's disease are associated with improved behavioral performance
00
113338113 2003 JOURNAL OF NEUROCHEMISTRY 85(6):1581-1591
Sergeant N; Bombois S; Ghestem A; Drobecq H; Kostanjevecki V; Missiaen C; Wattez A; David JP; Vanmechelen E; Sergheraert C; Delacourte A
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
14
114157114 2003 JOURNAL OF NEUROCHEMISTRY 87(3):609-619
Zou K; Kim D; Kakio A; Byun K; Gong JS; Kim J; Kim M; Sawamura N; Nishimoto S; Matsuzaki K; Lee B; Yanagisawa K; Michikawa M
Amyloid beta-protein (A beta)1-40 protects neurons from damage induced by A beta 1-42 in culture and in rat brain
01
115244115 2003 JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 62(12):1220-1227
Jankowsky JL; Xu GL; Fromholt D; Gonzales V; Borchelt DR
Environmental enrichment exacerbates amyloid plaque formation in a Transgenic mouse model of Alzheimer disease
01
116142116 2003 JOURNAL OF NEUROPHYSIOLOGY 89(6):3061-3069
Freir DB; Costello DA; Herron CE
A beta(25-35)-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil
23
117125117 2003 JOURNAL OF NEUROSCIENCE 23(6):1992-1996
Marr RA; Rockenstein E; Mukherjee A; Kindy MS; Hersh LB; Gage FH; Verma IM; Masliah E
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
116
118142118 2003 JOURNAL OF NEUROSCIENCE 23(12):5219-5226
Dickey CA; Loring JF; Montgomery J; Gordon MN; Eastman PS; Morgan D
Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein plus presenilin-1 transgenic mice
29
119347119 2003 JOURNAL OF NEUROSCIENCE 23(24):8453-8459
Beckmann N; Schuler A; Mueggler T; Meyer EP; Wiederhold KH; Staufenbiel M; Krucker T
Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease
03
120249120 2003 JOURNAL OF NEUROSCIENCE 23(26):8844-8853
Cirrito JR; May PC; O'Dell MA; Taylor JW; Parsadanian M; Cramer JW; Audia JE; Nissen JS; Bales KR; Paul SM; DeMattos RB; Holtzman DM
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life
02
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
121115121 2003 JOURNAL OF PHARMACOLOGICAL SCIENCES 91(4):330-333
Takata K; Kitamura Y; Umeki M; Tsuchiya D; Kakimura JI; Taniguchi T; Gebicke-Haerter PJ; Shimohama S
Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-Delta(12,14) prostaglandin J(2)-sensitive microglial activation
01
122766122 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(50):15359-15365
Bitan G; Tarus B; Vollers SS; Lashuel HA; Condron MM; Straub JE; Teplow DB
A molecular switch in amyloid assembly: Met(35) and amyloid beta-protein oligomerization
24
123251123 2003 JOURNAL OF VIROLOGY 77(13):7611-7622
Chiesa R; Piccardo P; Quaglio E; Drisaldi B; Si-Hoe SL; Takao M; Ghetti B; Harris DA
Molecular distinction between pathogenic and infectious properties of the prion protein
04
124211124 2003 LANCET NEUROLOGY 2(8):461-462
El-Agnaf OMA; Walsh DM; Allsop D
Soluble oligomers for the diagnosis of neurodegenerative diseases
00
125158125 2003 LANCET NEUROLOGY 2(8):506-511
Silverberg GD; Mayo M; Saul T; Rubenstein E; McGuire D
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis
14
1262217126 2003 MASS SPECTROMETRY REVIEWS 22(1):1-26
Konermann L; Simmons DA
Protein-folding kinetics and mechanisms studied by pulse-labeling and mass spectrometry
07
127195127 2003 MOLECULAR BIOLOGY OF THE CELL 14(11):4541-4556
Ardley HC; Scott GB; Rose SA; Tan NGS; Markham AF; Robinson PA
Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin
19
1281240128 2003 MOLECULAR NEUROBIOLOGY 27(3):249-276
Davis S; Laroche S
What can rodent models tell us about cognitive decline in Alzheimer's disease?
00
129345129 2003 MOLECULAR PHARMACOLOGY 64(5):1160-1168
Moss MA; Nichols MR; Reed DK; Hoh JH; Rosenberry TL
The peptide KLVFF-K-6 promotes beta-amyloid(1-40) protofibril growth by association but does not alter protofibril effects on cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)
01
130871130 2003 NATURE 426(6968):884-890
Dobson CM
Protein folding and misfolding
116
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
131426131 2003 NATURE 426(6968):900-904
Selkoe DJ
Folding proteins in fatal ways
09
132249132 2003 NATURE 426(6968):905-909
Cohen FE; Kelly JW
Therapeutic approaches to protein-misfolding diseases
111
133115133 2003 NATURE GENETICS 34(2):151-153
Levy-Nissenbaum E; Betz RC; Frydman M; Simon M; Lahat H; Bakhan T; Goldman B; Bygum A; Pierick M; Hillmer AM; Jonca N; Toribio J; Kruse R; Dewald G; Cichon S; Kubisch C; Guerrin M; Serre G; Nothen MM; Pras E
Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin
06
134113134 2003 NATURE NEUROSCIENCE 6(4):328-330
Carlson GA
A welcoming environment for amyloid plaques
01
1352148135 2003 NATURE REVIEWS NEUROSCIENCE 4(1):49-60
Soto C
Unfolding the role of protein misfolding in neurodegenerative diseases
342
136151136 2003 NEUROBIOLOGY OF AGING 24(3):415-420
Drake J; Link CD; Butterfield DA
Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model
412
137137137 2003 NEUROBIOLOGY OF DISEASE 13(3):177-190
Ye CP; Selkoe DJ; Hartley DM
Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures
34
138178138 2003 NEUROCHEMICAL RESEARCH 28(3-4):637-644
Beck M; Bigl V; Rossner S
Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo
01
139156139 2003 NEUROCHEMICAL RESEARCH 28(7):1009-1015
Sant'Angelo A; Trinchese F; Arancio O
Usefulness of Behavioral and electrophysiological studies in transgenic models of Alzheimer's disease
02
1402121140 2003 NEUROCHEMICAL RESEARCH 28(11):1683-1691
Klucken J; McLean PJ; Gomez-Tortosa E; Ingelsson M; Hyman BT
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
141360141 2003 NEUROCHEMICAL RESEARCH 28(11):1705-1713
Selkoe DJ
Aging, amyloid, and Alzheimer's disease: A perspective in honor of Carl Cotman
00
142137142 2003 NEURON 37(4):583-595
Sharon R; Bar-Joseph I; Frosch MP; Walsh DM; Hamilton JA; Selkoe DJ
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
526
143150143 2003 NEURON 37(6):911-924
Yang YF; Nishimura I; Imai Y; Takahashi R; Lu BW
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
237
144266144 2003 NEURON 37(6):925-937
Kamenetz F; Tomita T; Hsieh H; Seabrook G; Borchelt D; Iwatsubo T; Sisodia S; Malinow R
APP processing and synaptic function
931
145448145 2003 NEURON 39(3):409-421
Oddo S; Caccamo A; Shepherd JD; Murphy MP; Golde TE; Kayed R; Metherate R; Mattson MP; Akbari Y; LaFerla FM
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular A beta and synaptic dysfunction
634
146741146 2003 NEURON 40(6):1087-1093
Leissring MA; Farris W; Chang AY; Walsh DM; Wu XN; Sun XY; Frosch MP; Selkoe DJ
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
16
147220147 2003 NEUROPATHOLOGY 23(1):51-56
Mori H; Tomiyama T; Maeda N; Ozawa K; Wakasa K
Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome
00
1485402148 2003 NEUROPHARMACOLOGY 45(1):14-44
Dev KK; Hofele K; Barbieri S; Buchman VL; van der Putten H
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
110
149129149 2003 NEUROSCIENCE 116(2):511-517
Wang J; Ikonen S; Gurevicius K; Van Groen T; Tanila H
Altered auditory-evoked potentials in mice carrying mutated human amyloid presenilin-1 transgenes
00
150323150 2003 NEUROSCIENCE LETTERS 350(2):113-116
Kanemitsu H; Tomiyama T; Mori H
Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form
01
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
1513114151 2003 NEW ENGLAND JOURNAL OF MEDICINE 349(6):583-596
Merlini G; Bellotti V
Molecular mechanisms of amyloidosis
120
152135152 2003 NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY 77(11):1124-1126
Michikawa M
The role of cholesterol in the pathogenesis of Alzheimer's disease
00
1531201153 2003 PHARMACOLOGY & THERAPEUTICS 97(1):35-53
Kitamura Y; Nomura Y
Stress proteins and glial functions: possible therapeutic targets for neurodegenerative disorders
04
154265154 2003 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 361(1807):1205-1222
Vendruscolo M; Zurdo J; MacPhee CE; Dobson CM
Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems
24
155570155 2003 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 358(1432):821-828
Rowan MJ; Klyubin I; Cullen WK; Anwyl R
Synaptic plasticity in animal models of early Alzheimer's disease
14
1561164156 2003 POLIMERY 48(1):35-43
Jablonowska A; Dadlez M
A beta peptide oligomers - potential neurotoxic agents in Alzheimer's disease
00
157339157 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(1):330-335
Bitan G; Kirkitadze MD; Lomakin A; Vollers SS; Benedek GB; Teplow DB
Amyloid beta-protein (A beta) assembly: A beta 40 and A beta 42 oligomerize through distinct pathways
1527
158366158 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(3):1381-1386
Redwine JM; Kosofsky B; Jacobs RE; Games D; Reilly JF; Morrison JH; Young WG; Bloom FE
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis
19
159148159 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(11):6370-6375
Hoshi M; Sato M; Matsumoto S; Noguchi A; Yasutake K; Yoshida N; Sato K
Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3 beta
313
160152160 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(14):8182-8187
Dickerson TJ; Janda KD
Glycation of the amyloid beta-protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease
15
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
161452161 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(18):10417-10422
Gong YS; Chang L; Viola KL; Lacor PN; Lambert MP; Finch CE; Krafft GA; Klein WL
Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
1326
1623290162 2003 PROGRESS IN NEUROBIOLOGY 70(1):1-32
Turner PR; O'Connor K; Tate WP; Abraham WC
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
16
1634106163 2003 PROGRESS IN NEUROBIOLOGY 71(5):385-400
Sousa MM; Saraiva MJ
Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling
00
164178164 2003 PROTEASES AND THE REGULATION OF BIOLOGICAL PROCESSES 70:163-178
Carrell RW; Huntington JA
How serpins change their fold for better and for worse
01
165150165 2003 PROTEINS-STRUCTURE FUNCTION AND GENETICS 51(1):147-153
Vaiana SM; Palma-Vittorelli MB; Palma MU
Time scale of protein aggregation dictated by liquid-liquid demixing
16
1663204166 2003 REVIEWS IN THE NEUROSCIENCES 14(4):317-341
Stein TD; Johnson JA
Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity
00
167228167 2003 SCIENCE 299(5607):713-716
Hammarstrom P; Wiseman RL; Powers ET; Kelly JW
Prevention of transthyretin amyloid disease by changing protein misfolding energetics
642
168239168 2003 STROKE 34(2):335-337
Iadecola C; Gorelick PB
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110
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Johansson J
Molecular determinants for amyloid fibril formation: lessons from lung surfactant protein C
02
170190170 2003 THEORETICAL CHEMISTRY ACCOUNTS 109(1):8-21
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02
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
171420171 2003 TRENDS IN MOLECULAR MEDICINE 9(3):85-87
Dodart JC; Bales KR; Paul SM
Immunotherapy for Alzheimer's disease: will vaccination work?
14
172134172 2003 TRENDS IN NEUROSCIENCES 26(1):4-7
Ehlers MD
Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease
05
173178173 2003 TRENDS IN NEUROSCIENCES 26(4):207-214
Bush AI
The metallobiology of Alzheimer's disease
131
174125174 2003 TRENDS IN NEUROSCIENCES 26(8):407-410
Forman MS; Lee VMY; Trojanowski JQ
'Unfolding' pathways in neurodegenerative disease
08
175320175 2003 TRENDS IN NEUROSCIENCES 26(10):517-519
Welch K; Yuan JY
alpha-synuclein oligomerization: a role for lipids?
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176497176 2004 ACTA NEUROBIOLOGIAE EXPERIMENTALIS 64(1):19-31
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177993177 2004 ACTA NEUROBIOLOGIAE EXPERIMENTALIS 64(1):71-79
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Alzheimer's amyloid-beta (A beta) is an essential synaptic protein, not neurotoxic junk
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178140178 2004 ACTA NEUROBIOLOGIAE EXPERIMENTALIS 64(1):99-105
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Alzheimer's disease and acetylcholine receptors
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179257179 2004 ACTA NEUROPATHOLOGICA 107(5):389-398
Maat-Schieman MLC; Yamaguchi H; Hegeman-Kleinn IM; Welling-Graafland C; Natte R; Roos RAC; van Duinen SG
Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
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180292180 2004 ANNALS OF INTERNAL MEDICINE 140(8):627-638
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Alzheimer disease: Mechanistic understanding predicts novel therapies
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#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
181114181 2004 ANNALS OF NEUROLOGY 55(3):303-305
Jagust W
The proteomics of positron emission tomography
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Transthyretin aggregation under partially denaturing conditions is a downhill polymerization
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184330184 2004 BIOPHYSICAL JOURNAL 86(6):3585-3597
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Modeling amyloid beta-peptide insertion into lipid bilayers
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Interactions of Alzheimer amyloid peptides with cultured cells and brain tissue, and their biological consequences
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Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide
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Unraveling the pathogenesis of Parkinson's disease - the contribution of monogenic forms
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1913116191 2004 CURRENT MEDICINAL CHEMISTRY 11(4):491-499
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Promiscuous beta-strand interactions and the conformational diseases
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Klyubin I; Walsh DM; Cullen WK; Fadeeva JV; Anwyl R; Selkoe DJ; Rowan MJ
Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo
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193179193 2004 EXPERIMENTAL NEUROLOGY 188(2):224-237
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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid
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Transgenic mice overexpressing both amyloid B-protein and perlecan in pancreatic acinar cells
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196161196 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36(10):2066-2076
Clementi ME; Martorana GE; Pezzotti M; Giardina B; Misiti F
Methionine 35 oxidation reduces toxic effects of the amyloid beta-protein fragment (31-35) on human red blood cell
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197140197 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(13):12206-12212
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Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation
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Sirangelo I; Malmo C; Iannuzzi C; Mezzogiorno A; Bianco MR; Papa M; Irace G
Fibrillogenesis and cytotoxic activity of the amyloid-forming apomyoglobin mutant W7FW14F
00
199356199 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):14111-14119
Plakoutsi G; Taddei N; Stefani M; Chiti F
Aggregation of the acylphosphatase from Sulfolobus solfataricus - The folded and partially unfolded states can both be precursors for amyloid formation
00
200153200 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(15):14673-14678
Nagano S; Huang XD; Moir RD; Payton SM; Tanzi RE; Bush AI
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (A beta) and generates A beta-COX-2 hetero-oligomers that are increased in Alzheimer's disease
00

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