HistCite - index: Fragile X (expanded)

Mon Apr 4 11:08:40 2005

Papers with one of the following phrases in the title:
fragile x or FMRP or trinucleotitde expansion or nucleotide expansion or cgg

Nodes: 2647, Authors: 5321, Journals: 428, Outer References: 16458, Words: 3536
Collection span: 1967 - 2005
View: Overview. Sorted by LCR.
Page 1: 1 2 3 4 5 6 7 8 9

# LCR NCR Nodes / Date / Journal / Authors LCS GCS
1 196 429 513 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):31-60
SPANO LM; OPITZ JM
BIBLIOGRAPHY ON X-LINKED MENTAL-RETARDATION, THE FRAGILE-X AND RELATED SUBJECTS-IV (1988)
0 1
2 152 233 2417 2003 DEVELOPMENT AND PSYCHOPATHOLOGY 15(4):927-968
Reiss AL; Dant CC
The behavioral neurogenetics of fragile X syndrome: Analyzing gene-brain-behavior relationships in child developmental psychopathologies
0 0
3 140 197 1779 1998 JOURNAL OF MEDICAL GENETICS 35(7):579-589
de Vries BBA; Halley DJJ; Oostra BA; Niermeijer MF
The fragile X syndrome
32 52
4 108 154 2153 2001 GENETICS IN MEDICINE 3(5):359-371
Crawford DC; Acuna JM; Sherman SL
FMR1 and the fragile X syndrome: Human genome epidemiology review
17 25
5 103 406 172 1984 AMERICAN JOURNAL OF MEDICAL GENETICS 17(1):5-94
OPITZ JM; SUTHERLAND GR
CONFERENCE REPORT - INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION
52 116
6 99 179 2248 2002 ANNUAL REVIEW OF NEUROSCIENCE 25:315-338
O'Donnell WT; Warren ST
A decade of molecular studies of fragile X syndrome
0 63
7 97 168 2413 2003 CYTOGENETIC AND GENOME RESEARCH 100(1-4):111-123
Bakker CE; Oostra BA
Understanding fragile X syndrome: insights from animal models
4 5
8 89 136 1869 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 88(1):11-24
Kaufmann WE; Reiss AL
Molecular and cellular genetics of fragile X syndrome
16 28
9 83 119 974 1992 BRITISH JOURNAL OF PSYCHIATRY 160:24-35
TURK J
THE FRAGILE-X SYNDROME - ON THE WAY TO A BEHAVIORAL-PHENOTYPE
25 46
10 76 123 1710 1997 WESTERN JOURNAL OF MEDICINE 166(2):129-137
Hagerman RJ
Fragile X syndrome - Molecular and clinical insights and treatment issues
6 8
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
11 76 116 1978 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 97(2):153-163
Bardoni B; Mandel JL; Fisch GS
FMR1 gene and fragile X syndrome
12 21
12 71 125 1335 1995 ANNUAL REVIEW OF NEUROSCIENCE 18:77-99
WARREN ST; ASHLEY CT
TRIPLET REPEAT EXPANSION MUTATIONS - THE EXAMPLE OF FRAGILE-X SYNDROME
26 58
13 71 117 1433 1995 PEDIATRIC RESEARCH 38(5):629-637
OOSTRA BA; HALLEY DJJ
COMPLEX BEHAVIOR OF SIMPLE REPEATS - THE FRAGILE-X SYNDROME
8 11
14 71 143 1798 1998 ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA 98(9):54-63
Vorsanova SG; Vekhova NV; Demidova IA; Yurov YB
Syndrome of mental retardation, linked with fragile X-chromosome: problems of diagnostics and inheritance
0 0
15 70 102 2215 2001 SEMINARS IN REPRODUCTIVE MEDICINE 19(2):159-165
Kenneson A; Warren ST
The female and the fragile X reviewed
1 3
16 69 87 2411 2003 CURRENT OPINION IN PEDIATRICS 15(6):559-566
Chiurazzi P; Neri G; Oostra BA
Understanding the biological underpinnings of fragile X syndrome
2 5
17 67 98 2304 2002 JOURNAL OF NEUROSCIENCE RESEARCH 70(5):623-630
Todd PK; Malter JS
Fragile X mental retardation protein in plasticity and disease
1 4
18 66 100 2139 2001 CLINICAL GENETICS 60(6):399-408
Oostra BA; Chiurazzi P
The fragile X gene and its function
5 11
19 66 84 2260 2002 CYTOGENETIC AND GENOME RESEARCH 99(1-4):257-264
Oostra BA; Willemsen R
The X chromosome and fragile X mental retardation
2 3
20 65 94 2142 2001 CURRENT OPINION IN PSYCHIATRY 14(5):443-449
Eliez S; Feinstein C
The fragile X syndrome: bridging the gap from gene to behavior
0 1
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
21 65 108 2183 2001 MOLECULAR GENETICS AND METABOLISM 74(1-2):89-97
Hagerman RJ; Hagerman PJ
Fragile X syndrome: A model of gene-brain-behavior relationships
1 2
22 64 95 1517 1996 CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA 5(4):895-&
Hagerman RJ
Fragile X syndrome
1 9
23 63 96 1906 1999 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 3(6):639-645
Pimentel MMG
Fragile X syndrome
0 5
24 63 105 2205 2001 REVISTA DE NEUROLOGIA 33:S51-S57
Hagerman RJ; Hagerman PJ
Fragile X syndrome: A model of gene-brain-behaviour relationships
0 0
25 60 138 1080 1993 AMERICAN JOURNAL OF MEDICAL GENETICS 48(2):112-121
FISCH GS
WHAT IS ASSOCIATED WITH THE FRAGILE-X SYNDROME
21 34
26 60 94 1526 1996 DEVELOPMENTAL PSYCHOLOGY 32(3):416-424
Hagerman RJ
Biomedical advances in developmental psychology: The case of fragile X syndrome
3 8
27 60 117 2073 2000 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 6(2):96-106
Mazzocco MMM
Advances in research on the fragile X syndrome
20 24
28 60 93 2259 2002 CURRENT OPINION IN GENETICS & DEVELOPMENT 12(3):284-293
Bardoni B; Mandel JL
Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes
31 39
29 60 135 2506 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61(14):1714-1728
Denman RB; Dolzhanskaya N; Sung YJ
Regulating a translational regulator: mechanisms cells use to control the activity of the fragile X mental retardation protein
1 2
30 60 103 2536 2004 JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY 45(6):1042-1053
Cornish KM; Turk J; Wilding J; Sudhalter V; Munir F; et al.
Annotation: Deconstructing the attention deficit in fragile X syndrome: a developmental neuropsychological approach
0 0
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
31 59 77 2647 2005 TRENDS IN GENETICS 21(1):37-45
Zhang YQ; Broadie K
Fathoming fragile X in fruit flies
1 1
32 58 91 1233 1994 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 24(1):1-10
ROUSSEAU F
THE FRAGILE-X SYNDROME - IMPLICATIONS OF MOLECULAR-GENETICS FOR THE CLINICAL SYNDROME
8 11
33 58 71 1530 1996 EUROPEAN PSYCHIATRY 11(5):233-243
Franke P; Barbe B; Leboyer M; Maier W
Fragile X syndrome .2. Cognitive and behavioral correlates of mutations of the FMR-1 gene
5 6
34 56 112 483 1987 JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY 26(4):463-471
BREGMAN JD; DYKENS E; WATSON M; ORT SI; LECKMAN JF
FRAGILE-X SYNDROME - VARIABILITY OF PHENOTYPIC-EXPRESSION
24 41
35 55 82 2309 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):135-144
Kaufmann WE; Cohen S; Sun HT; Ho G
Molecular phenotype of fragile X syndrome: FMRP, FXRPs, and protein targets
1 1
36 53 104 1761 1998 JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS 28(5):393-405
Feinstein C; Reiss AL
Autism: The point of view from fragile X studies
18 45
37 53 82 2020 2000 HUMAN MOLECULAR GENETICS 9(6):901-908
Jin P; Warren ST
Understanding the molecular basis of fragile X syndrome
44 82
38 52 98 1876 1999 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 77(4):331-342
Khandjian EW
Biology of the fragile X mental retardation protein, an RNA-binding protein
14 22
39 52 101 2599 2004 NEUROPSYCHOLOGIA 42(14):1934-1947
Moore CJ; Daly EM; Schmitz N; Tassone F; Tysoe C; et al.
A neuropsychological investigation of male premutation carriers of fragile X syndrome
0 0
40 51 134 1670 1997 INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL 21 21:221-247
Fisch GS
Longitudinal assessment of cognitive-behavioral deficits produced by the fragile-X mutation
0 1
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
41 51 120 2507 2004 CNS DRUGS 18(11):687-703
Tsiouris JA; Brown WT
Neuropsychiatric symptoms of fragile X syndrome - Pathophysiology and pharmacotherapy
0 0
42 51 75 2598 2004 NEUROLOGY INDIA 52(1):36-42
Pandey UB; Phadke SR; Mittal B
Molecular diagnosis and genetic counseling for fragile X mental retardation
0 0
43 50 75 1770 1998 JOURNAL OF CLINICAL LIGAND ASSAY 21(4):424-431
Feldman GL; Monaghan KG
Fragile X syndrome: A review of the molecular and clinical features
0 0
44 49 76 997 1992 JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES 33(7):1127-1139
HAGERMAN RJ
FRAGILE-X SYNDROME - ADVANCES AND CONTROVERSY
3 7
45 47 73 2590 2004 NATURE CELL BIOLOGY 6(11):1048-1053
Jin P; Alisch RS; Warren ST
RNA and microRNAs in fragile X mental retardation
2 3
46 46 131 1360 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):199-217
Binstock TC
Fragile X and the amygdala: Cognitive, interpersonal, emotional, and neuroendocrine considerations
4 4
47 46 64 1858 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 84(3):250-261
Tassone F; Hagerman RJ; Ikle DN; Dyer PN; Lampe M; et al.
FMRP expression as a potential prognostic indicator in fragile X syndrome
60 67
48 45 78 1355 1995 CLINICS IN LABORATORY MEDICINE 15(4):859-&
Brown WT
Perspectives and molecular diagnosis of the fragile X syndrome
2 2
49 45 85 2132 2001 BRAIN RESEARCH BULLETIN 56(3-4):375-382
Bardoni B; Schenck A; Mandel JL
The Fragile X mental retardation protein
6 9
50 45 118 2435 2003 INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL 27 27:83-119
Murphy MM; Abbeduto L
Language and communication in fragile X syndrome
0 0
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
51 43 97 364 1986 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 477:129-150
BROWN WT; JENKINS EC; KRAWCZUN MS; WISNIEWSKI K; RUDELLI R; et al.
THE FRAGILE-X SYNDROME
10 13
52 43 64 2311 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):148-155
Hoogeveen AT; Willemsen R; Oostra BA
Fragile X syndrome, the fragile X related proteins, and animal models
1 4
53 43 136 2412 2003 CYTOGENETIC AND GENOME RESEARCH 100(1-4):65-76
Greene E; Handa V; Kumari D; Usdin K
Transcription defects induced by repeat expansion: fragile X syndrome, FRAXE mental retardation, progressive myoclonus epilepsy type 1, and Friedreich ataxia
0 0
54 42 66 1083 1993 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 117(11):1121-1125
TSONGALIS GJ; SILVERMAN LM
MOLECULAR PATHOLOGY OF THE FRAGILE-X SYNDROME
0 2
55 42 81 1251 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):536-542
WARREN ST; NELSON DL
ADVANCES IN MOLECULAR ANALYSIS OF FRAGILE-X SYNDROME
74 129
56 42 70 1439 1995 SEMINARS IN CELL BIOLOGY 6(1):5-11
NELSON DL
THE FRAGILE-X SYNDROMES
4 16
57 42 64 1648 1997 CURRENT OPINION IN NEUROLOGY 10(2):142-147
Chakrabarti L; Davies KE
Fragile X syndrome
2 4
58 42 92 1692 1997 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 3(4):313-322
Abbeduto L; Hagerman RJ
Language and communication in fragile X syndrome
10 17
59 42 62 2022 2000 HUMAN MOLECULAR GENETICS 9(12):1759-1769
Crawford DC; Zhang FP; Wilson B; Warren ST; Sherman SL
Fragile X CGG repeat structures among African-Americans: identification of a novel factor responsible for repeat instability
7 11
60 42 139 2262 2002 DEVELOPMENTAL PSYCHOBIOLOGY 40(3):323-338
Churchill JD; Grossman AW; Irwin SA; Galvez R; Klintsova AY; et al.
A converging-methods approach to fragile X syndrome
2 8
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
61 42 102 2575 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):60-67
Willemsen R; Oostra BA; Bassell GJ; Dictenberg J
The fragile X syndrome: From molecular genetics to neurobiology
2 5
62 41 101 2465 2003 NEUROPSYCHOLOGY 17(4):646-657
Loesch DZ; Bui QM; Grigsby J; Butler E; Epstein J; et al.
Effect of the fragile X status categories and the fragile X mental retardation protein levels on executive functioning in males and females with fragile X
1 1
63 41 80 2480 2004 AMERICAN JOURNAL OF HUMAN GENETICS 74(5):805-816
Hagerman PJ; Hagerman RJ
The fragile-X premutation: A maturing perspective
8 14
64 41 114 2519 2004 GENES BRAIN AND BEHAVIOR 3(6):337-359
Yan QJ; Asafo-Adjei PK; Arnold HM; Brown RE; Bauchwitz RP
A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse
1 1
65 41 65 2555 2004 JOURNAL OF MOLECULAR BIOLOGY 343(1):43-53
Menon RP; Gibson TJ; Pastore A
The C terminus of fragile X mental retardation protein interacts with the multi-domain ran-binding protein in the microtubule-organising centre
0 0
66 40 112 1342 1995 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1271(2-3):293-303
FLANNERY AV; HIRST MC; KNIGHT SJL; RITCHIE RJ; DAVIES KE
THE FRAGILE-X SYNDROME
2 5
67 40 75 1365 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):252-269
Cohen IL
Behavioral profiles of autistic and nonautistic fragile X males
12 13
68 40 74 1523 1996 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 61:679-687
Eberhart DE; Warren ST
The molecular basis of fragile X syndrome
7 8
69 40 62 1534 1996 GIORNALE DI NEUROPSICHIATRIA DELL ETA EVOLUTIVA 16(2):147-154
Veneselli E; Biancheri R; Perrone MV
Neuropsychiatric aspects in the fragile X syndrome
0 0
70 40 52 2431 2003 HUMAN MOLECULAR GENETICS 12(23):3087-3096
Mazroui R; Huot ME; Tremblay S; Boilard N; Labelle Y; et al.
Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs
4 4
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
71 40 97 2560 2004 JOURNAL OF NEUROSCIENCE 24(25):5798-5809
Michel CI; Kraft R; Restifo LL
Defective neuronal development in the mushroom bodies of Drosophila Fragile X Mental Retardation 1 Mutants
6 7
72 39 66 2064 2000 JOURNAL OF MEDICAL GENETICS 37(11):842-850
Salat U; Bardoni B; Wohrle D; Steinbach P
Increase of FMRP expression, raised levels of FMR1 mRNA, and clonal selection in proliferating cells with unmethylated fragile X repeat expansions: a clue to the sex bias in the transmission of full mutations?
4 6
73 39 53 2429 2003 HUMAN MOLECULAR GENETICS 12(14):1689-1698
Bardoni B; Castets M; Huot ME; Schenck A; Adinolfi S; et al.
82-FIP, a novel FMRP (Fragile X Mental Retardation Protein) interacting protein, shows a cell cycle-dependent intracellular localization
8 8
74 39 74 2569 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):17-24
Hessl D; Rivera SM; Reiss AL
The neuroanatomy and neuroendocrinotogy of fragile X syndrome
1 2
75 39 66 2571 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):31-41
Loesch DZ; Huggins RM; Hagerman RJ
Phenotypic variation and FMRP levels in fragile X
1 1
76 38 118 365 1986 ANNUAL REVIEW OF GENETICS 20:109-145
NUSSBAUM RL; LEDBETTER DH
FRAGILE-X SYNDROME - A UNIQUE MUTATION IN MAN
65 112
77 38 83 629 1989 ARCHIVES FRANCAISES DE PEDIATRIE 46(3):211-216
LELOUARN P; MORAINE C; PERROT A; BARTHELEMY C; GARREAU B; et al.
AUTISM AND FRAGILE X-SYNDROME
3 5
78 38 77 978 1992 CLINICAL SCIENCE 83(3):255-264
HIRST MC; KNIGHT SJL; BELL MV; SUPER M; DAVIES KE
THE FRAGILE-X SYNDROME
3 3
79 38 84 1106 1993 GENETIC COUNSELING 4(4):245-263
MAES B; FRYNS JP; VANWALLEGHEM M; VANDENBERGHE H
FRAGILE-X SYNDROME AND AUTISM - A PREVALENT ASSOCIATION OR A MISINTERPRETED CONNECTION
6 13
80 38 61 1174 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):298-308
HAGERMAN RJ; HULL CE; SAFANDA JF; CARPENTER I; STALEY LW; et al.
HIGH FUNCTIONING FRAGILE-X MALES - DEMONSTRATION OF AN UNMETHYLATED FULLY EXPANDED FMR-1 MUTATION ASSOCIATED WITH PROTEIN EXPRESSION
69 97
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
81 38 61 1824 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 83(4):221-236
Holden JJA; Percy M; Allingham-Hawkins D; Brown WT; Chiurazzi P; et al.
Eighth International Workshop on the Fragile X Syndrome and X-linked Mental Retardation, August 16-22, 1997
1 4
82 38 51 2258 2002 CURRENT OPINION IN GENETICS & DEVELOPMENT 12(3):278-283
Hagerman RJ; Hagerman PJ
The fragile X premutation: into the phenotypic fold
15 25
83 38 53 2403 2003 BIOLOGY OF THE CELL 95(3-4):221-228
Schaeffer C; Beaulande M; Ehresmann C; Ehresmann B; Moine H
The RNA binding protein FMRP: new connections and missing links
3 8
84 37 55 989 1992 HUMAN GENETICS 88(3):335-343
FOLLETTE PJ; LAIRD CD
ESTIMATING THE STABILITY OF THE PROPOSED IMPRINTED STATE OF THE FRAGILE-X MUTATION WHEN TRANSMITTED BY FEMALES
2 3
85 37 57 1898 1999 HUMAN BIOLOGY 71(1):55-68
Arrieta I; Gil A; Nunez T; Telez M; Martinez B; et al.
Stability of the FMRI CGG repeat in a Basque sample
4 5
86 37 73 2140 2001 COGNITIVE NEUROPSYCHOLOGY 18(1):1-18
Simon JA; Keenan JM; Pennington BF; Taylor AK; Hagerman RJ
Discourse processing in women with fragile X syndrome: Evidence for a deficit establishing coherence
8 10
87 37 47 2157 2001 HUMAN MOLECULAR GENETICS 10(14):1449-1454
Kenneson A; Zhang FP; Hagedorn CH; Warren ST
Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers
36 46
88 37 55 2476 2003 TRENDS IN BIOCHEMICAL SCIENCES 28(3):152-158
Jin P; Warren ST
New insights into fragile X syndrome: from molecules to neurobehaviors
18 34
89 36 54 1288 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(3):609-618
DEGRAAFF E; WILLEMSEN R; ZHONG N; DEDIESMULDERS CEM; BROWN WT; et al.
INSTABILITY OF THE CGG REPEAT AND EXPRESSION OF THE FMR1 PROTEIN IN A MALE FRAGILE-X PATIENT WITH A LUNG-TUMOR
26 32
90 36 59 1423 1995 MEDICINA-BUENOS AIRES 55(5):457-466
BANARES VG
UPDATING THE FRAGILE-X SYNDROME
0 0
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
91 36 62 2408 2003 CELL 112(3):317-327
Zalfa F; Giorgi M; Primerano B; Moro A; Di Penta A; et al.
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at Synapses
37 69
92 36 60 2477 2003 TRENDS IN GENETICS 19(3):148-154
Kooy RF
Of mice and the fragile X syndrome
10 13
93 35 45 1113 1993 HUMAN GENETICS 92(5):491-498
STEINBACH P; WOHRLE D; TARIVERDIAN G; KENNERKNECHT I; BARBI G; et al.
MOLECULAR ANALYSIS OF MUTATIONS IN THE GENE FMR-1 SEGREGATING IN FRAGILE X-FAMILIES
7 11
94 35 63 1571 1996 PRENATAL DIAGNOSIS 16(13):1199-1211
Sutherland GR; Mulley JC
Fragile X syndrome and Fragile XE mental retardation
3 9
95 35 50 1882 1999 CURRENT OPINION IN PSYCHIATRY 12(5):573-578
Harris SW; Hagerman RJ
Fragile X syndrome: new developments
2 2
96 35 55 2023 2000 HUMAN MOLECULAR GENETICS 9(19):2909-2918
Crawford DC; Wilson B; Sherman SL
Factors involved in the initial mutation of the fragile X CGG repeat as determined by sperm small pool PCR
3 11
97 35 62 2133 2001 BRAIN RESEARCH BULLETIN 56(3-4):383-387
Chiurazzi P; Neri G
Pharmacological reactivation of inactive genes: The fragile X experience
0 1
98 35 47 2155 2001 HUMAN GENETICS 108(6):450-458
Weinhausel A; Haas OA
Evaluation of the fragile X (FRAXA) syndrome with methylation-sensitive PCR
2 6
99 35 66 2320 2002 MONATSSCHRIFT KINDERHEILKUNDE 150(12):1486-+
Backes M; von Gontard A
Behavioural phenotype of fragile X syndrome
0 0
100 35 62 2380 2003 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 122A(1):13-23
Loesch DZ; Huggins RM; Bui QM; Taylor AK; Pratt C; et al.
Effect of fragile x status categories and FMRP deficits on cognitive profiles estimated by robust pedigree analysis
0 5
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
101 35 49 2516 2004 EXPERIMENTAL NEUROLOGY 189(2):343-353
Schrier M; Severijnen LA; Reis S; Rife M; van't Padje S; et al.
Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells
0 0
102 34 42 1322 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(5):1006-1018
ROUSSEAU F; ROUILLARD P; MOREL ML; KHANDJIAN EW; MORGAN K
PREVALENCE OF CARRIERS OF PREMUTATION-SIZE ALLELES OF THE FMRI GENE AND IMPLICATIONS FOR THE POPULATION-GENETICS OF THE FRAGILE-X SYNDROME
86 114
103 34 44 1879 1999 CLINICAL GENETICS 55(5):346-351
Tassone F; Longshore J; Zunich J; Steinbach P; Salat U; et al.
Tissue-specific methylation differences in a fragile X premutation carrier
2 4
104 34 53 2130 2001 BRAIN 124:1610-1618
Eliez S; Blasey CM; Freund LS; Hastie T; Reiss AL
Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome
9 15
105 34 88 2131 2001 BRAIN RESEARCH BULLETIN 56(3-4):367-373
Grabczyk E; Kumari D; Usdin K
Fragile X syndrome and Friedreich's ataxia: Two different paradigms for repeat induced transcript insufficiency
0 4
106 34 43 2427 2003 HUMAN GENETICS 113(5):371-376
Arocena DG; Breece KE; Hagerman PJ
Distribution of CGG repeat sizes within the fragile X mental retardation 1 (FMR1) homologue in a non-human primate population
1 2
107 34 67 2568 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):11-16
Cornish K; Sudhalter V; Turk J
Attention and language in fragile X
1 1
108 33 48 976 1992 CHROMOSOMA 101(7):381-387
OOSTRA BA; VERKERK AJMH
THE FRAGILE X-SYNDROME - ISOLATION OF THE FMR-1 GENE AND CHARACTERIZATION OF THE FRAGILE-X MUTATION
12 26
109 33 50 1463 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):203-208
Chiurazzi P; Macpherson J; Sherman S; Neri G
Significance of linkage disequilibrium between the fragile X locus and its flanking markers
18 25
110 33 40 1856 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 84(3):233-239
Taylor AK; Tassone F; Dyer PN; Hersch SM; Harris JB; et al.
Tissue heterogeneity of the FMR1 mutation in a high-functioning male with fragile X syndrome
17 24
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
111 33 48 1979 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 97(3):183-188
Willemsen R; Oostra BA
FMRP detection assay for the diagnosis of the fragile X syndrome
2 4
112 33 54 2087 2000 OPTOMETRY AND VISION SCIENCE 77(11):592-599
Block SS; Brusca-Vega R; Pizzi WJ; Berry-Kravis E; Maino DM; et al.
Cognitive and visual processing skills and their relationship to mutation size in full and premutation female fragile X carriers
0 0
113 33 52 2316 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):179-186
Keysor CS; Mazzocco MMM
A developmental approach to understanding fragile X syndrome in females
8 9
114 33 95 2619 2004 TRENDS IN NEUROSCIENCES 27(7):370-377
Bear MF; Huber KM; Warren ST
The mGIuR theory of fragile X mental retardation
8 10
115 32 83 218 1984 JOURNAL OF MEDICAL GENETICS 21(2):84-91
DEARCE MA; KEARNS A
THE FRAGILE X-SYNDROME - THE PATIENTS AND THEIR CHROMOSOMES
9 20
116 32 85 482 1987 JOURNAL OF PEDIATRICS 110(6):821-831
CHUDLEY AE; HAGERMAN RJ
FRAGILE-X SYNDROME
53 80
117 32 50 550 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):655-663
FISCH GS; COHEN IL; JENKINS EC; BROWN WT
SCREENING DEVELOPMENTALLY DISABLED MALE POPULATIONS FOR FRAGILE-X - THE EFFECT OF SAMPLE-SIZE
18 22
118 32 75 1359 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):187-198
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1	196	429	513 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):31-60 SPANO LM; OPITZ JM BIBLIOGRAPHY ON X-LINKED MENTAL-RETARDATION, THE FRAGILE-X AND RELATED SUBJECTS-IV (1988)	0	1
2	152	233	2417 2003 DEVELOPMENT AND PSYCHOPATHOLOGY 15(4):927-968 Reiss AL; Dant CC The behavioral neurogenetics of fragile X syndrome: Analyzing gene-brain-behavior relationships in child developmental psychopathologies	0	0
3	140	197	1779 1998 JOURNAL OF MEDICAL GENETICS 35(7):579-589 de Vries BBA; Halley DJJ; Oostra BA; Niermeijer MF The fragile X syndrome	32	52
4	108	154	2153 2001 GENETICS IN MEDICINE 3(5):359-371 Crawford DC; Acuna JM; Sherman SL FMR1 and the fragile X syndrome: Human genome epidemiology review	17	25
5	103	406	172 1984 AMERICAN JOURNAL OF MEDICAL GENETICS 17(1):5-94 OPITZ JM; SUTHERLAND GR CONFERENCE REPORT - INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION	52	116
6	99	179	2248 2002 ANNUAL REVIEW OF NEUROSCIENCE 25:315-338 O'Donnell WT; Warren ST A decade of molecular studies of fragile X syndrome	0	63
7	97	168	2413 2003 CYTOGENETIC AND GENOME RESEARCH 100(1-4):111-123 Bakker CE; Oostra BA Understanding fragile X syndrome: insights from animal models	4	5
8	89	136	1869 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 88(1):11-24 Kaufmann WE; Reiss AL Molecular and cellular genetics of fragile X syndrome	16	28
9	83	119	974 1992 BRITISH JOURNAL OF PSYCHIATRY 160:24-35 TURK J THE FRAGILE-X SYNDROME - ON THE WAY TO A BEHAVIORAL-PHENOTYPE	25	46
10	76	123	1710 1997 WESTERN JOURNAL OF MEDICINE 166(2):129-137 Hagerman RJ Fragile X syndrome - Molecular and clinical insights and treatment issues	6	8
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11	76	116	1978 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 97(2):153-163 Bardoni B; Mandel JL; Fisch GS FMR1 gene and fragile X syndrome	12	21
12	71	125	1335 1995 ANNUAL REVIEW OF NEUROSCIENCE 18:77-99 WARREN ST; ASHLEY CT TRIPLET REPEAT EXPANSION MUTATIONS - THE EXAMPLE OF FRAGILE-X SYNDROME	26	58
13	71	117	1433 1995 PEDIATRIC RESEARCH 38(5):629-637 OOSTRA BA; HALLEY DJJ COMPLEX BEHAVIOR OF SIMPLE REPEATS - THE FRAGILE-X SYNDROME	8	11
14	71	143	1798 1998 ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA 98(9):54-63 Vorsanova SG; Vekhova NV; Demidova IA; Yurov YB Syndrome of mental retardation, linked with fragile X-chromosome: problems of diagnostics and inheritance	0	0
15	70	102	2215 2001 SEMINARS IN REPRODUCTIVE MEDICINE 19(2):159-165 Kenneson A; Warren ST The female and the fragile X reviewed	1	3
16	69	87	2411 2003 CURRENT OPINION IN PEDIATRICS 15(6):559-566 Chiurazzi P; Neri G; Oostra BA Understanding the biological underpinnings of fragile X syndrome	2	5
17	67	98	2304 2002 JOURNAL OF NEUROSCIENCE RESEARCH 70(5):623-630 Todd PK; Malter JS Fragile X mental retardation protein in plasticity and disease	1	4
18	66	100	2139 2001 CLINICAL GENETICS 60(6):399-408 Oostra BA; Chiurazzi P The fragile X gene and its function	5	11
19	66	84	2260 2002 CYTOGENETIC AND GENOME RESEARCH 99(1-4):257-264 Oostra BA; Willemsen R The X chromosome and fragile X mental retardation	2	3
20	65	94	2142 2001 CURRENT OPINION IN PSYCHIATRY 14(5):443-449 Eliez S; Feinstein C The fragile X syndrome: bridging the gap from gene to behavior	0	1
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21	65	108	2183 2001 MOLECULAR GENETICS AND METABOLISM 74(1-2):89-97 Hagerman RJ; Hagerman PJ Fragile X syndrome: A model of gene-brain-behavior relationships	1	2
22	64	95	1517 1996 CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA 5(4):895-& Hagerman RJ Fragile X syndrome	1	9
23	63	96	1906 1999 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 3(6):639-645 Pimentel MMG Fragile X syndrome	0	5
24	63	105	2205 2001 REVISTA DE NEUROLOGIA 33:S51-S57 Hagerman RJ; Hagerman PJ Fragile X syndrome: A model of gene-brain-behaviour relationships	0	0
25	60	138	1080 1993 AMERICAN JOURNAL OF MEDICAL GENETICS 48(2):112-121 FISCH GS WHAT IS ASSOCIATED WITH THE FRAGILE-X SYNDROME	21	34
26	60	94	1526 1996 DEVELOPMENTAL PSYCHOLOGY 32(3):416-424 Hagerman RJ Biomedical advances in developmental psychology: The case of fragile X syndrome	3	8
27	60	117	2073 2000 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 6(2):96-106 Mazzocco MMM Advances in research on the fragile X syndrome	20	24
28	60	93	2259 2002 CURRENT OPINION IN GENETICS & DEVELOPMENT 12(3):284-293 Bardoni B; Mandel JL Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes	31	39
29	60	135	2506 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61(14):1714-1728 Denman RB; Dolzhanskaya N; Sung YJ Regulating a translational regulator: mechanisms cells use to control the activity of the fragile X mental retardation protein	1	2
30	60	103	2536 2004 JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY 45(6):1042-1053 Cornish KM; Turk J; Wilding J; Sudhalter V; Munir F; et al. Annotation: Deconstructing the attention deficit in fragile X syndrome: a developmental neuropsychological approach	0	0
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31	59	77	2647 2005 TRENDS IN GENETICS 21(1):37-45 Zhang YQ; Broadie K Fathoming fragile X in fruit flies	1	1
32	58	91	1233 1994 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 24(1):1-10 ROUSSEAU F THE FRAGILE-X SYNDROME - IMPLICATIONS OF MOLECULAR-GENETICS FOR THE CLINICAL SYNDROME	8	11
33	58	71	1530 1996 EUROPEAN PSYCHIATRY 11(5):233-243 Franke P; Barbe B; Leboyer M; Maier W Fragile X syndrome .2. Cognitive and behavioral correlates of mutations of the FMR-1 gene	5	6
34	56	112	483 1987 JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY 26(4):463-471 BREGMAN JD; DYKENS E; WATSON M; ORT SI; LECKMAN JF FRAGILE-X SYNDROME - VARIABILITY OF PHENOTYPIC-EXPRESSION	24	41
35	55	82	2309 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):135-144 Kaufmann WE; Cohen S; Sun HT; Ho G Molecular phenotype of fragile X syndrome: FMRP, FXRPs, and protein targets	1	1
36	53	104	1761 1998 JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS 28(5):393-405 Feinstein C; Reiss AL Autism: The point of view from fragile X studies	18	45
37	53	82	2020 2000 HUMAN MOLECULAR GENETICS 9(6):901-908 Jin P; Warren ST Understanding the molecular basis of fragile X syndrome	44	82
38	52	98	1876 1999 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 77(4):331-342 Khandjian EW Biology of the fragile X mental retardation protein, an RNA-binding protein	14	22
39	52	101	2599 2004 NEUROPSYCHOLOGIA 42(14):1934-1947 Moore CJ; Daly EM; Schmitz N; Tassone F; Tysoe C; et al. A neuropsychological investigation of male premutation carriers of fragile X syndrome	0	0
40	51	134	1670 1997 INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL 21 21:221-247 Fisch GS Longitudinal assessment of cognitive-behavioral deficits produced by the fragile-X mutation	0	1
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41	51	120	2507 2004 CNS DRUGS 18(11):687-703 Tsiouris JA; Brown WT Neuropsychiatric symptoms of fragile X syndrome - Pathophysiology and pharmacotherapy	0	0
42	51	75	2598 2004 NEUROLOGY INDIA 52(1):36-42 Pandey UB; Phadke SR; Mittal B Molecular diagnosis and genetic counseling for fragile X mental retardation	0	0
43	50	75	1770 1998 JOURNAL OF CLINICAL LIGAND ASSAY 21(4):424-431 Feldman GL; Monaghan KG Fragile X syndrome: A review of the molecular and clinical features	0	0
44	49	76	997 1992 JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES 33(7):1127-1139 HAGERMAN RJ FRAGILE-X SYNDROME - ADVANCES AND CONTROVERSY	3	7
45	47	73	2590 2004 NATURE CELL BIOLOGY 6(11):1048-1053 Jin P; Alisch RS; Warren ST RNA and microRNAs in fragile X mental retardation	2	3
46	46	131	1360 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):199-217 Binstock TC Fragile X and the amygdala: Cognitive, interpersonal, emotional, and neuroendocrine considerations	4	4
47	46	64	1858 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 84(3):250-261 Tassone F; Hagerman RJ; Ikle DN; Dyer PN; Lampe M; et al. FMRP expression as a potential prognostic indicator in fragile X syndrome	60	67
48	45	78	1355 1995 CLINICS IN LABORATORY MEDICINE 15(4):859-& Brown WT Perspectives and molecular diagnosis of the fragile X syndrome	2	2
49	45	85	2132 2001 BRAIN RESEARCH BULLETIN 56(3-4):375-382 Bardoni B; Schenck A; Mandel JL The Fragile X mental retardation protein	6	9
50	45	118	2435 2003 INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL 27 27:83-119 Murphy MM; Abbeduto L Language and communication in fragile X syndrome	0	0
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51	43	97	364 1986 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 477:129-150 BROWN WT; JENKINS EC; KRAWCZUN MS; WISNIEWSKI K; RUDELLI R; et al. THE FRAGILE-X SYNDROME	10	13
52	43	64	2311 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):148-155 Hoogeveen AT; Willemsen R; Oostra BA Fragile X syndrome, the fragile X related proteins, and animal models	1	4
53	43	136	2412 2003 CYTOGENETIC AND GENOME RESEARCH 100(1-4):65-76 Greene E; Handa V; Kumari D; Usdin K Transcription defects induced by repeat expansion: fragile X syndrome, FRAXE mental retardation, progressive myoclonus epilepsy type 1, and Friedreich ataxia	0	0
54	42	66	1083 1993 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 117(11):1121-1125 TSONGALIS GJ; SILVERMAN LM MOLECULAR PATHOLOGY OF THE FRAGILE-X SYNDROME	0	2
55	42	81	1251 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):536-542 WARREN ST; NELSON DL ADVANCES IN MOLECULAR ANALYSIS OF FRAGILE-X SYNDROME	74	129
56	42	70	1439 1995 SEMINARS IN CELL BIOLOGY 6(1):5-11 NELSON DL THE FRAGILE-X SYNDROMES	4	16
57	42	64	1648 1997 CURRENT OPINION IN NEUROLOGY 10(2):142-147 Chakrabarti L; Davies KE Fragile X syndrome	2	4
58	42	92	1692 1997 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 3(4):313-322 Abbeduto L; Hagerman RJ Language and communication in fragile X syndrome	10	17
59	42	62	2022 2000 HUMAN MOLECULAR GENETICS 9(12):1759-1769 Crawford DC; Zhang FP; Wilson B; Warren ST; Sherman SL Fragile X CGG repeat structures among African-Americans: identification of a novel factor responsible for repeat instability	7	11
60	42	139	2262 2002 DEVELOPMENTAL PSYCHOBIOLOGY 40(3):323-338 Churchill JD; Grossman AW; Irwin SA; Galvez R; Klintsova AY; et al. A converging-methods approach to fragile X syndrome	2	8
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61	42	102	2575 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):60-67 Willemsen R; Oostra BA; Bassell GJ; Dictenberg J The fragile X syndrome: From molecular genetics to neurobiology	2	5
62	41	101	2465 2003 NEUROPSYCHOLOGY 17(4):646-657 Loesch DZ; Bui QM; Grigsby J; Butler E; Epstein J; et al. Effect of the fragile X status categories and the fragile X mental retardation protein levels on executive functioning in males and females with fragile X	1	1
63	41	80	2480 2004 AMERICAN JOURNAL OF HUMAN GENETICS 74(5):805-816 Hagerman PJ; Hagerman RJ The fragile-X premutation: A maturing perspective	8	14
64	41	114	2519 2004 GENES BRAIN AND BEHAVIOR 3(6):337-359 Yan QJ; Asafo-Adjei PK; Arnold HM; Brown RE; Bauchwitz RP A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse	1	1
65	41	65	2555 2004 JOURNAL OF MOLECULAR BIOLOGY 343(1):43-53 Menon RP; Gibson TJ; Pastore A The C terminus of fragile X mental retardation protein interacts with the multi-domain ran-binding protein in the microtubule-organising centre	0	0
66	40	112	1342 1995 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1271(2-3):293-303 FLANNERY AV; HIRST MC; KNIGHT SJL; RITCHIE RJ; DAVIES KE THE FRAGILE-X SYNDROME	2	5
67	40	75	1365 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):252-269 Cohen IL Behavioral profiles of autistic and nonautistic fragile X males	12	13
68	40	74	1523 1996 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 61:679-687 Eberhart DE; Warren ST The molecular basis of fragile X syndrome	7	8
69	40	62	1534 1996 GIORNALE DI NEUROPSICHIATRIA DELL ETA EVOLUTIVA 16(2):147-154 Veneselli E; Biancheri R; Perrone MV Neuropsychiatric aspects in the fragile X syndrome	0	0
70	40	52	2431 2003 HUMAN MOLECULAR GENETICS 12(23):3087-3096 Mazroui R; Huot ME; Tremblay S; Boilard N; Labelle Y; et al. Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs	4	4
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71	40	97	2560 2004 JOURNAL OF NEUROSCIENCE 24(25):5798-5809 Michel CI; Kraft R; Restifo LL Defective neuronal development in the mushroom bodies of Drosophila Fragile X Mental Retardation 1 Mutants	6	7
72	39	66	2064 2000 JOURNAL OF MEDICAL GENETICS 37(11):842-850 Salat U; Bardoni B; Wohrle D; Steinbach P Increase of FMRP expression, raised levels of FMR1 mRNA, and clonal selection in proliferating cells with unmethylated fragile X repeat expansions: a clue to the sex bias in the transmission of full mutations?	4	6
73	39	53	2429 2003 HUMAN MOLECULAR GENETICS 12(14):1689-1698 Bardoni B; Castets M; Huot ME; Schenck A; Adinolfi S; et al. 82-FIP, a novel FMRP (Fragile X Mental Retardation Protein) interacting protein, shows a cell cycle-dependent intracellular localization	8	8
74	39	74	2569 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):17-24 Hessl D; Rivera SM; Reiss AL The neuroanatomy and neuroendocrinotogy of fragile X syndrome	1	2
75	39	66	2571 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):31-41 Loesch DZ; Huggins RM; Hagerman RJ Phenotypic variation and FMRP levels in fragile X	1	1
76	38	118	365 1986 ANNUAL REVIEW OF GENETICS 20:109-145 NUSSBAUM RL; LEDBETTER DH FRAGILE-X SYNDROME - A UNIQUE MUTATION IN MAN	65	112
77	38	83	629 1989 ARCHIVES FRANCAISES DE PEDIATRIE 46(3):211-216 LELOUARN P; MORAINE C; PERROT A; BARTHELEMY C; GARREAU B; et al. AUTISM AND FRAGILE X-SYNDROME	3	5
78	38	77	978 1992 CLINICAL SCIENCE 83(3):255-264 HIRST MC; KNIGHT SJL; BELL MV; SUPER M; DAVIES KE THE FRAGILE-X SYNDROME	3	3
79	38	84	1106 1993 GENETIC COUNSELING 4(4):245-263 MAES B; FRYNS JP; VANWALLEGHEM M; VANDENBERGHE H FRAGILE-X SYNDROME AND AUTISM - A PREVALENT ASSOCIATION OR A MISINTERPRETED CONNECTION	6	13
80	38	61	1174 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):298-308 HAGERMAN RJ; HULL CE; SAFANDA JF; CARPENTER I; STALEY LW; et al. HIGH FUNCTIONING FRAGILE-X MALES - DEMONSTRATION OF AN UNMETHYLATED FULLY EXPANDED FMR-1 MUTATION ASSOCIATED WITH PROTEIN EXPRESSION	69	97
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81	38	61	1824 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 83(4):221-236 Holden JJA; Percy M; Allingham-Hawkins D; Brown WT; Chiurazzi P; et al. Eighth International Workshop on the Fragile X Syndrome and X-linked Mental Retardation, August 16-22, 1997	1	4
82	38	51	2258 2002 CURRENT OPINION IN GENETICS & DEVELOPMENT 12(3):278-283 Hagerman RJ; Hagerman PJ The fragile X premutation: into the phenotypic fold	15	25
83	38	53	2403 2003 BIOLOGY OF THE CELL 95(3-4):221-228 Schaeffer C; Beaulande M; Ehresmann C; Ehresmann B; Moine H The RNA binding protein FMRP: new connections and missing links	3	8
84	37	55	989 1992 HUMAN GENETICS 88(3):335-343 FOLLETTE PJ; LAIRD CD ESTIMATING THE STABILITY OF THE PROPOSED IMPRINTED STATE OF THE FRAGILE-X MUTATION WHEN TRANSMITTED BY FEMALES	2	3
85	37	57	1898 1999 HUMAN BIOLOGY 71(1):55-68 Arrieta I; Gil A; Nunez T; Telez M; Martinez B; et al. Stability of the FMRI CGG repeat in a Basque sample	4	5
86	37	73	2140 2001 COGNITIVE NEUROPSYCHOLOGY 18(1):1-18 Simon JA; Keenan JM; Pennington BF; Taylor AK; Hagerman RJ Discourse processing in women with fragile X syndrome: Evidence for a deficit establishing coherence	8	10
87	37	47	2157 2001 HUMAN MOLECULAR GENETICS 10(14):1449-1454 Kenneson A; Zhang FP; Hagedorn CH; Warren ST Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers	36	46
88	37	55	2476 2003 TRENDS IN BIOCHEMICAL SCIENCES 28(3):152-158 Jin P; Warren ST New insights into fragile X syndrome: from molecules to neurobehaviors	18	34
89	36	54	1288 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(3):609-618 DEGRAAFF E; WILLEMSEN R; ZHONG N; DEDIESMULDERS CEM; BROWN WT; et al. INSTABILITY OF THE CGG REPEAT AND EXPRESSION OF THE FMR1 PROTEIN IN A MALE FRAGILE-X PATIENT WITH A LUNG-TUMOR	26	32
90	36	59	1423 1995 MEDICINA-BUENOS AIRES 55(5):457-466 BANARES VG UPDATING THE FRAGILE-X SYNDROME	0	0
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91	36	62	2408 2003 CELL 112(3):317-327 Zalfa F; Giorgi M; Primerano B; Moro A; Di Penta A; et al. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at Synapses	37	69
92	36	60	2477 2003 TRENDS IN GENETICS 19(3):148-154 Kooy RF Of mice and the fragile X syndrome	10	13
93	35	45	1113 1993 HUMAN GENETICS 92(5):491-498 STEINBACH P; WOHRLE D; TARIVERDIAN G; KENNERKNECHT I; BARBI G; et al. MOLECULAR ANALYSIS OF MUTATIONS IN THE GENE FMR-1 SEGREGATING IN FRAGILE X-FAMILIES	7	11
94	35	63	1571 1996 PRENATAL DIAGNOSIS 16(13):1199-1211 Sutherland GR; Mulley JC Fragile X syndrome and Fragile XE mental retardation	3	9
95	35	50	1882 1999 CURRENT OPINION IN PSYCHIATRY 12(5):573-578 Harris SW; Hagerman RJ Fragile X syndrome: new developments	2	2
96	35	55	2023 2000 HUMAN MOLECULAR GENETICS 9(19):2909-2918 Crawford DC; Wilson B; Sherman SL Factors involved in the initial mutation of the fragile X CGG repeat as determined by sperm small pool PCR	3	11
97	35	62	2133 2001 BRAIN RESEARCH BULLETIN 56(3-4):383-387 Chiurazzi P; Neri G Pharmacological reactivation of inactive genes: The fragile X experience	0	1
98	35	47	2155 2001 HUMAN GENETICS 108(6):450-458 Weinhausel A; Haas OA Evaluation of the fragile X (FRAXA) syndrome with methylation-sensitive PCR	2	6
99	35	66	2320 2002 MONATSSCHRIFT KINDERHEILKUNDE 150(12):1486-+ Backes M; von Gontard A Behavioural phenotype of fragile X syndrome	0	0
100	35	62	2380 2003 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 122A(1):13-23 Loesch DZ; Huggins RM; Bui QM; Taylor AK; Pratt C; et al. Effect of fragile x status categories and FMRP deficits on cognitive profiles estimated by robust pedigree analysis	0	5
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101	35	49	2516 2004 EXPERIMENTAL NEUROLOGY 189(2):343-353 Schrier M; Severijnen LA; Reis S; Rife M; van't Padje S; et al. Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells	0	0
102	34	42	1322 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(5):1006-1018 ROUSSEAU F; ROUILLARD P; MOREL ML; KHANDJIAN EW; MORGAN K PREVALENCE OF CARRIERS OF PREMUTATION-SIZE ALLELES OF THE FMRI GENE AND IMPLICATIONS FOR THE POPULATION-GENETICS OF THE FRAGILE-X SYNDROME	86	114
103	34	44	1879 1999 CLINICAL GENETICS 55(5):346-351 Tassone F; Longshore J; Zunich J; Steinbach P; Salat U; et al. Tissue-specific methylation differences in a fragile X premutation carrier	2	4
104	34	53	2130 2001 BRAIN 124:1610-1618 Eliez S; Blasey CM; Freund LS; Hastie T; Reiss AL Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome	9	15
105	34	88	2131 2001 BRAIN RESEARCH BULLETIN 56(3-4):367-373 Grabczyk E; Kumari D; Usdin K Fragile X syndrome and Friedreich's ataxia: Two different paradigms for repeat induced transcript insufficiency	0	4
106	34	43	2427 2003 HUMAN GENETICS 113(5):371-376 Arocena DG; Breece KE; Hagerman PJ Distribution of CGG repeat sizes within the fragile X mental retardation 1 (FMR1) homologue in a non-human primate population	1	2
107	34	67	2568 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):11-16 Cornish K; Sudhalter V; Turk J Attention and language in fragile X	1	1
108	33	48	976 1992 CHROMOSOMA 101(7):381-387 OOSTRA BA; VERKERK AJMH THE FRAGILE X-SYNDROME - ISOLATION OF THE FMR-1 GENE AND CHARACTERIZATION OF THE FRAGILE-X MUTATION	12	26
109	33	50	1463 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):203-208 Chiurazzi P; Macpherson J; Sherman S; Neri G Significance of linkage disequilibrium between the fragile X locus and its flanking markers	18	25
110	33	40	1856 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 84(3):233-239 Taylor AK; Tassone F; Dyer PN; Hersch SM; Harris JB; et al. Tissue heterogeneity of the FMR1 mutation in a high-functioning male with fragile X syndrome	17	24
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111	33	48	1979 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 97(3):183-188 Willemsen R; Oostra BA FMRP detection assay for the diagnosis of the fragile X syndrome	2	4
112	33	54	2087 2000 OPTOMETRY AND VISION SCIENCE 77(11):592-599 Block SS; Brusca-Vega R; Pizzi WJ; Berry-Kravis E; Maino DM; et al. Cognitive and visual processing skills and their relationship to mutation size in full and premutation female fragile X carriers	0	0
113	33	52	2316 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):179-186 Keysor CS; Mazzocco MMM A developmental approach to understanding fragile X syndrome in females	8	9
114	33	95	2619 2004 TRENDS IN NEUROSCIENCES 27(7):370-377 Bear MF; Huber KM; Warren ST The mGIuR theory of fragile X mental retardation	8	10
115	32	83	218 1984 JOURNAL OF MEDICAL GENETICS 21(2):84-91 DEARCE MA; KEARNS A THE FRAGILE X-SYNDROME - THE PATIENTS AND THEIR CHROMOSOMES	9	20
116	32	85	482 1987 JOURNAL OF PEDIATRICS 110(6):821-831 CHUDLEY AE; HAGERMAN RJ FRAGILE-X SYNDROME	53	80
117	32	50	550 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):655-663 FISCH GS; COHEN IL; JENKINS EC; BROWN WT SCREENING DEVELOPMENTALLY DISABLED MALE POPULATIONS FOR FRAGILE-X - THE EFFECT OF SAMPLE-SIZE	18	22
118	32	75	1359 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):187-198 Abrams MT; Reiss AL Quantitative brain imaging studies of fragile X syndrome	2	3
119	32	57	1675 1997 JOURNAL OF INHERITED METABOLIC DISEASE 20(2):139-151 Hoogeveen AT; Oostra BA The fragile X syndrome	6	10
120	32	52	1937 2000 AMERICAN JOURNAL OF HUMAN GENETICS 66(2):480-493 Crawford DC; Schwartz CE; Meadows KL; Newman JL; Taft LF; et al. Survey of the fragile X syndrome CGG repeat and the short-tendem-repeat and single-nucleotide-polymorphism haplotypes in an African American population	9	18
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121	32	45	2079 2000 MOLECULAR MEDICINE TODAY 6(5):193-198 Kooy RF; Willemsen R; Oostra BA Fragile X syndrome at the turn of the century	15	21
122	32	45	2085 2000 NUCLEIC ACIDS RESEARCH 28(7):1535-1541 Weisman-Shomer P; Cohen E; Fry M Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures	6	11
123	32	51	2298 2002 JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 23(6):416-423 Loesch DZ; Huggins RM; Bui QM; Epstein JL; Taylor AK; et al. Effect of the deficits of fragile X mental retardation protein on cognitive status of fragile X males and females assessed by robust pedigree analysis	6	6
124	32	39	2348 2003 AMERICAN JOURNAL OF HUMAN GENETICS 72(2):454-464 Nolin SL; Brown WT; Glicksman A; Houck GE; Gargano AD; et al. Expansion of the fragile X CGG repeat in females with premutation or intermediate alleles	13	21
125	32	55	2526 2004 GROWTH HORMONE & IGF RESEARCH 14:S158-S165 Mandel JL; Biancalana V Fragile X mental retardation syndrome: from pathogenesis to diagnostic issues	0	0
126	31	61	1177 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):317-327 ABRAMS MT; REISS AL; FREUND LS; BAUMGARDNER TL; CHASE GA; et al. MOLECULAR-NEUROBEHAVIORAL ASSOCIATIONS IN FEMALES WITH THE FRAGILE-X FULL MUTATION	50	67
127	31	49	1708 1997 REVISTA DE NEUROLOGIA 25(143):1068-1071 EstevezGonzalez A; Roig C; Piles S; Pineda M; GarciaSanchez C Fragile-X syndrome and mental retardation	1	1
128	31	107	1731 1998 CURRENT OPINION IN GENETICS & DEVELOPMENT 8(2):245-253 Tapscott SJ; Klesert TR; Widrow RJ; Stoger R; Laird CD Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes	1	10
129	31	44	2016 2000 GENETICS IN MEDICINE 2(4):242-248 Burman RW; Anoe KS; Popovich BW Fragile X full mutations ave more similar in siblings than in unrelated patients: further evidence for a familial factor in CGG repeat dynamics	1	2
130	31	74	2074 2000 MOLECULAR AND CELLULAR BIOLOGY 20(22):8536-8547 Wan LL; Dockendorff TC; Jongens TA; Dreyfuss G Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein	44	57
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131	31	49	2284 2002 GENETICS AND MOLECULAR BIOLOGY 25(1):1-6 de Diego Y; Hmadcha A; Moron F; Lucas M; Carrasco M; et al. Fragile X founder effect and distribution of CGG repeats among the mentally retarded population of Andalusia, South Spain	0	0
132	31	40	2288 2002 HUMAN MOLECULAR GENETICS 11(4):371-378 Dombrowski C; Levesque S; Morel ML; Rouillard P; Morgan K; et al. Premutation and intermediate-size FMR1 alleles in 10,572 males from the general population: Loss of an AGG interruption is a late event in the generation of fragile X syndrome alleles	22	34
133	31	44	2373 2003 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 116A(1):44-51 Steyaert J; Legius E; Borghgraef M; Fryns JP A distinct neurocognitive phenotype in female fragile-X premutation carriers assessed with visual attention tasks	0	4
134	31	38	2489 2004 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 128A(3):250-255 Penagarikano O; Gil A; Telez M; Ortega B; Flores P; et al. A new insight into fragile X syndrome among Basque population	0	0
135	30	58	625 1989 AMERICAN JOURNAL OF ORTHOPSYCHIATRY 59(1):142-152 HAGERMAN RJ; SOBESKY WE PSYCHOPATHOLOGY IN FRAGILE-X-SYNDROME	29	41
136	30	39	672 1989 ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE 17(2):91-97 VONGONTARD A PSYCHOPATHOLOGY ASSOCIATED WITH THE FRAGILE-X SYNDROME	1	2
137	30	56	917 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):47-55 FISCH GS IS AUTISM ASSOCIATED WITH THE FRAGILE-X SYNDROME	20	36
138	30	38	1170 1994 AMERICAN JOURNAL OF HUMAN GENETICS 55(2):225-237 ROUSSEAU F; HEITZ D; TARLETON J; MACPHERSON J; MALMGREN H; et al. A MULTICENTER STUDY ON GENOTYPE-PHENOTYPE CORRELATIONS IN THE FRAGILE-X-SYNDROME, USING DIRECT DIAGNOSIS WITH PROBE STB-12.3 - THE FIRST 2,253 CASES	129	172
139	30	48	1250 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):507-514 TAYLOR AK; SAFANDA JF; FALL MZ; QUINCE C; LANG KA; et al. MOLECULAR PREDICTORS OF COGNITIVE INVOLVEMENT IN FEMALE CARRIERS OF FRAGILE-X SYNDROME	80	92
140	30	52	1435 1995 PEDIATRICS 95(5):744-752 BAUMGARDNER TL; REISS AL; FREUND LS; ABRAMS MT SPECIFICATION OF THE NEUROBEHAVIORAL PHENOTYPE IN MALES WITH FRAGILE-X SYNDROME	49	75
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141	30	49	1540 1996 HUMAN MOLECULAR GENETICS 5(3):319-330 Eichler EE; Macpherson JN; Murray A; Jacobs PA; Chakravarti A; et al. Haplotype and interspersion analysis of the FMR1 CGG repeat identifies two different mutational pathways for the origin of the fragile X syndrome	32	51
142	30	43	1620 1997 AMERICAN JOURNAL OF HUMAN GENETICS 61(6):1362-1369 Kenneson A; Cramer DW; Warren ST Fragile X premutations are not a major cause of early menopause	13	22
143	30	41	1795 1998 REVISTA MEDICA DE CHILE 126(8):911-918 Jara L; Lopez M; Mellado C; Aspillaga M; Avendano I; et al. Clinical and metabolic screening for fragile X syndrome in 300 patients with unspecific mental retardation	1	1
144	30	59	1974 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 95(2):150-156 Backes M; Genc B; Schreck J; Doerfler W; Lehmkuhl G; et al. Cognitive and behavioral profile of fragile X boys: Correlations to molecular data	8	12
145	30	43	2240 2002 AMERICAN JOURNAL OF MEDICAL GENETICS 111(3):243-252 Mingroni-Netto RC; Angeli CB; Auricchio MTBM; Leal-Mesquita ER; Ribeiro-dos-Santos AKC; et al. Distribution of CGG repeats and FRAXAC1/DXS548 alleles in South American populations	1	3
146	30	56	2437 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(18):15669-15678 Sung YJ; Dolzhanskaya N; Nolin SL; Brown T; Currie JR; et al. The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo	8	13
147	30	54	2540 2004 JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 25(6):392-398 Goodlin-Jones BL; Tassone F; Gane LW Autistic spectrum disorder and the fragile X premutation	0	0
148	29	36	1034 1993 AMERICAN JOURNAL OF DISEASES OF CHILDREN 147(11):1236-1241 HULL C; HAGERMAN RJ A STUDY OF THE PHYSICAL, BEHAVIORAL, AND MEDICAL PHENOTYPE, INCLUDING ANTHROPOMETRIC MEASURES, OF FEMALES WITH FRAGILE-X SYNDROME	29	39
149	29	38	1445 1996 AMERICAN JOURNAL OF HUMAN GENETICS 59(6):1252-1261 Nolin SL; Lewis FA; Ye LL; Houck GE; Glicksman AE; et al. Familial transmission of the FMR1 CGG repeat	43	54
150	29	43	1466 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):226-233 Zhong N; Kajanoja E; Smits B; Pietrofesa J; Curley D; et al. Fragile X founder effects and new mutations in Finland	14	26
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151	29	43	1479 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(2):302-308 deGraaff E; deVries BBA; Willemsen R; vanHemel JO; Mohkamsing S; et al. The fragile X phenotype in a mosaic male with a deletion showing expression of the FMR1 protein in 28% of the cells	12	13
152	29	40	2094 2001 AMERICAN JOURNAL OF HUMAN GENETICS 69(2):351-360 Toledano-Alhadef H; Basel-Vanagaite L; Magal N; Davidov B; Ehrlich S; et al. Fragile-X carrier screening and the prevalence of premutation and full-mutation carriers in Israel	13	22
153	29	45	2158 2001 HUMAN MOLECULAR GENETICS 10(16):1693-1699 Bontekoe CJM; Bakker CE; Nieuwenhuizen IM; van der Linde H; Lans H; et al. Instability of a (CGG)(98) repeat in the Fmr1 promoter	12	15
154	29	58	2382 2003 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 118B(1):81-88 Barnea-Goraly N; Eliez S; Hedeus M; Menon V; White CD; et al. White matter tract alterations in fragile X syndrome: Preliminary evidence from diffusion tensor imaging	0	6
155	29	60	2386 2003 AMERICAN JOURNAL ON MENTAL RETARDATION 108(5):314-326 Demark JL; Feldman MA; Holden JJA Behavioral relationship between autism and fragile X syndrome	1	2
156	29	55	2570 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):25-30 Hagerman PJ; Hagerman RJ Fragile X-associated tremor/ataxia syndrome (FXTAS)	0	1
157	29	49	2627 2005 BRAIN AND COGNITION 57(1):53-60 Cornish K; Kogan C; Turk J; Manly T; James N; et al. The emerging fragile X premutation phenotype: Evidence from the domain of social cognition	0	0
158	29	46	2646 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(6):2180-2185 Aschrafi A; Cunningham BA; Edelman GM; Vanderklish PW The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain	0	0
159	28	73	696 1990 BIOLOGICAL PSYCHIATRY 27(2):223-240 REISS AL; FREUND L FRAGILE X-SYNDROME	22	28
160	28	44	1154 1993 NATURE GENETICS 4(2):143-146 REYNIERS E; VITS L; DEBOULLE K; VANROY B; VANVELZEN D; et al. THE FULL MUTATION IN THE FMR-1 GENE OF MALE FRAGILE-X PATIENTS IS ABSENT IN THEIR SPERM	96	170
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161	28	64	1171 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 50(2):190-200 MAES B; FRYNS JP; VANWALLEGHEM M; VANDENBERGHE H COGNITIVE-FUNCTIONING AND INFORMATION-PROCESSING OF ADULT MENTALLY-RETARDED MEN WITH FRAGILE-X SYNDROME	17	24
162	28	92	1332 1995 AMERICAN JOURNAL OF MEDICAL GENETICS 60(6):480-493 Schapiro MB; Murphy DGM; Hagerman RJ; Azari NP; Alexander GE; et al. Adult fragile X syndrome: Neuropsychology, brain anatomy, and metabolism	21	31
163	28	77	1575 1996 SCREENING 4(4):175-192 Meadows KL; Sherman SL Fragile X syndrome: Examination of issues pertaining to population-based screening	2	2
164	28	44	1619 1997 AMERICAN JOURNAL OF HUMAN GENETICS 61(4):961-967 Gronskov K; Hjalgrim H; Bjerager MO; BrondumNielsen K Deletion of all CGG repeats plus flanking sequences in FMR1 does not abolish gene expression	5	6
165	28	43	1634 1997 ANNALS OF MEDICINE 29(6):563-567 Oostra BA; Hoogeveen AT Animal model for fragile X syndrome	3	8
166	28	42	1712 1998 AMERICAN JOURNAL OF HUMAN GENETICS 63(3):776-785 Ashley-Koch AE; Robinson H; Glicksman AE; Nolin SL; Schwartz CE; et al. Examination of factors associated with instability of the FMR1 CGG repeat	15	22
167	28	47	1830 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 83(4):286-295 Kaufmann WE; Abrams MT; Chen WM; Reiss AL Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome	30	36
168	28	40	1981 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 97(3):195-203 Tassone F; Hagerman RJ; Chamberlain WD; Hagerman PJ Transcription of the FMR1 gene in individuals with fragile X syndrome	29	34
169	28	43	2078 2000 MOLECULAR DIAGNOSIS 5(3):169-178 Gold B; Radu D; Balanko A; Chiang CS Diagnosis of Fragile X syndrome by Southern blot hybridization using a chemiluminescent probe: A laboratory protocol	0	1
170	28	53	2083 2000 NEUROSCIENCE RESEARCH COMMUNICATIONS 26(3):255-263 de Vries BBA; Oostra BA The fragile X syndrome: A model for mental retardation	0	0
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171	28	57	2289 2002 HUMAN MOLECULAR GENETICS 11(24):3007-3017 Mazroui R; Huot ME; Tremblay S; Filion C; Labelle Y; et al. Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression	24	31
172	28	41	2344 2002 RNA-A PUBLICATION OF THE RNA SOCIETY 8(12):1482-1488 Primerano B; Tassone F; Hagerman RJ; Hagerman P; Amaldi F; et al. Reduced FMR1 mRNA translation efficiency in Fragile X patients with premutations	11	14
173	28	61	2420 2003 EXPERIMENTAL CELL RESEARCH 289(1):95-107 Bardoni B; Willemsen R; Weiler IJ; Schenck A; Severijnen LA; et al. NUFIP 1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosome	6	7
174	28	34	2421 2003 GENETIC TESTING 7(4):303-308 Gasteiger M; Grasbon-Frod E; Neitzel B; Kooy F; Holinski-Feder E FMR1 gene deletion/reversion: A pitfall of fragile X carrier testing	0	0
175	28	41	2425 2003 HEREDITY 90(3):206-211 Arrieta I; Penagarikano O; Tele M; Ortega B; Flores P; et al. The FMR1 CGG repeat and linked microsatellite markers in two Basque valleys	0	0
176	28	41	2448 2003 JOURNAL OF MEDICAL GENETICS 40(7):535-539 de Vries BBA; Severijnen LA; Jacobs A; Olmer R; Halley DJJ; et al. FMRP expression studies in blood and hair roots in a fragile X family with methylation mosaics	1	1
177	28	62	2501 2004 BRAIN 127:591-601 Kogan CS; Boutet I; Cornish K; Zangenehpour S; Mullen KT; et al. Differential impact of the FMR1 gene on visual processing in fragile X syndrome	2	2
178	28	50	2614 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(50):17504-17509 Weiler IJ; Spangler CC; Klintsova AY; Grossman AW; Kim SH; et al. Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses	0	0
179	28	50	2621 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 132A(1):25-32 Skinner M; Hooper S; Hatton DD; Robert J; Mirrett P; et al. Mapping nonverbal IQ in young boys with fragile X syndrome	0	0
180	27	63	612 1988 QUARTERLY JOURNAL OF MEDICINE 69(258):755-763 FROSTERISKENIUS U; PATTERSON MN; BELL MV; BLOOMFIELD J; DAVIES KE MOLECULAR ANALYSIS OF THE FRAGILE-X SYNDROME	1	1
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181	27	41	970 1992 ARCHIVES FRANCAISES DE PEDIATRIE 49(2):99-103 BURSZTEJN C; ALEMBIK Y; STOLL C; POUPIER G; FELLER L; et al. FRAGILE-X SYNDROME ASSOCIATED WITH INFANTILE-AUTISM AND PSYCHOTIC DISORDERS	0	2
182	27	59	1025 1992 PSYCHIATRIC GENETICS 2(4):277-300 BOLTON P; PICKLES A; BUTLER L; SUMMERS D; WEBB T; et al. FRAGILE-X IN FAMILIES MULTIPLEX FOR AUTISM AND RELATED PHENOTYPES - PREVALENCE AND CRITERIA FOR CYTOGENETIC DIAGNOSIS	1	7
183	27	37	1203 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):474-481 HAGERMAN RJ; WILSON P; STALEY LW; LANG KA; FAN T; et al. EVALUATION OF SCHOOL-CHILDREN AT HIGH-RISK FOR FRAGILE-X-SYNDROME UTILIZING BUCCAL CELL FMR-1 TESTING	17	36
184	27	46	1246 1994 HUMAN MOLECULAR GENETICS 3(9):1553-1560 HIRST MC; GREWAL PK; DAVIES KE PRECURSOR ARRAYS FOR TRIPLET REPEAT EXPANSION AT THE FRAGILE-X LOCUS	56	108
185	27	42	1324 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(6):1414-1425 ASHLEY AE; SHERMAN SL POPULATION-DYNAMICS OF A MEIOTIC MITOTIC EXPANSION MODEL FOR THE FRAGILE-X SYNDROME	18	20
186	27	43	1336 1995 ARCHIVES OF DISEASE IN CHILDHOOD 72(1):3-5 TURK J FRAGILE-X SYNDROME	2	4
187	27	36	1363 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):230-241 Brun C; Obiols JE; Cheema A; OConnor R; Riddle J; et al. Longitudinal IQ changes in fragile X females	1	1
188	27	61	1427 1995 NEUROPSYCHOLOGY 9(4):470-480 MAZZOCCO MMM; FREUND LS; BAUMGARDNER TL; FORMAN L; REISS AL NEUROPSYCHOLOGICAL AND PSYCHOSOCIAL EFFECTS OF THE FMR-1 FULL MUTATION - CASE-REPORT OF MONOZYGOTIC TWINS DISCORDANT FOR THE FRAGILE-X SYNDROME	5	6
189	27	35	1640 1997 BRAZILIAN JOURNAL OF GENETICS 20(4):731-739 Mingroni-Netto RC; Pavanello RCM; Otto PA; Vianna-Morgante AM Experience with molecular and cytogenetic diagnosis of fragile X syndrome in Brazilian families	2	2
190	27	48	1655 1997 FOLIA HISTOCHEMICA ET CYTOBIOLOGICA 35(3):135-141 Szot M The fragile X syndrome	0	0
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191	27	51	1778 1998 JOURNAL OF MEDICAL GENETICS 35(2):103-111 Wohrle D; Salat U; Glaser D; Mucke J; Meisel-Stosiek M; et al. Unusual mutations in high functioning fragile X males: apparent instability of expanded unmethylated CGG repeats	19	32
192	27	52	1800 1999 AMERICAN JOURNAL OF HUMAN GENETICS 65(3):680-688 Nolin SL; Houck GE; Gargano AD; Blumstein H; Dobkin CS; et al. FMR1 CCG-repeat instability by single sperm and lymphocytes of fragile-X premutation males	8	15
193	27	53	1821 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 82(1):25-30 Abrams MT; Kaufmann WE; Rousseau F; Oostra BA; Wolozin B; et al. FMR1 gene expression in olfactory neuroblasts from two males with fragile X syndrome	8	11
194	27	67	1900 1999 HUMAN MOLECULAR GENETICS 8(12):2293-2302 Burman RW; Popovich BW; Jacky PB; Turker MS Fully expanded FMR1 CGG repeats exhibit a length-and differentiation-dependent instability in cell hybrids that is independent of DNA methylation	9	12
195	27	42	1967 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 92(4):229-236 Lachiewicz AM; Dawson DV; Spiridigliozzi GA Physical characteristics of young boys with fragile X syndrome: Reasons for difficulties in making a diagnosis in young males	12	13
196	27	35	1970 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 94(3):232-236 Tassone F; Hagerman RJ; Loesch DZ; Lachiewicz A; Taylor AK; et al. Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA	20	26
197	27	59	2034 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(42):33134-33141 Uliel L; Weisman-Shomer P; Oren-Jazans H; Newcomb T; Loeb LA; et al. Human Ku antigen tightly binds and stabilizes a tetrahelical form of the fragile X syndrome d(CGG)(n) expanded sequence	1	7
198	27	39	2117 2001 AMERICAN JOURNAL OF MEDICAL GENETICS 103(4):314-319 Johnston C; Eliez S; Dyer-Friedman J; Hessl D; Glaser B; et al. Neurobehavioral phenotype in carriers of the fragile X premutation	8	9
199	27	32	2125 2001 ANNALS OF CLINICAL BIOCHEMISTRY 38:264-271 Saha S; Karmakar P; Chatterjee C; Banerjee D; Das S; et al. Fragile X syndrome in Calcutta, India	2	4
200	27	43	2238 2002 AMERICAN JOURNAL OF MEDICAL GENETICS 110(3):226-233 Crawford DC; Meadows KL; Newman JL; Taft LF; Scott E; et al. Prevalence of the fragile x syndrome in African-Americans	3	4
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201	27	80	2336 2002 OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA 29(2):367-+ Wenstrom KD Fragile X and other trinucleotide repeat diseases	1	3
202	27	40	2399 2003 BIOCHEMISTRY 42(35):10437-10444 Adinolfi S; Ramos A; Martin SR; Dal Piaz F; Pucci P; et al. The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA binding	6	7
203	27	61	2456 2003 MOLECULAR BRAIN RESEARCH 110(2):267-278 Todd PK; Malter JS; Mack KJ Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors	4	3
204	27	42	2521 2004 GENETIC EPIDEMIOLOGY 26(4):294-304 Huggins RM; Loesch DZ; Qian GQ; Bui QM; Mitchell RJ; et al. Hierarchical Bayes model for random haplotype and family effects in the transmission of fragile-X	0	0
205	26	44	1027 1992 TRENDS IN GENETICS 8(7):249-255 RICHARDS RI; SUTHERLAND GR FRAGILE X-SYNDROME - THE MOLECULAR PICTURE COMES INTO FOCUS	13	39
206	26	42	1178 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):328-338 KOLEHMAINEN K; KARANT Y MODELING METHYLATION AND IQ SCORES IN FRAGILE-X FEMALES AND MOSAIC MALES	4	7
207	26	39	1347 1995 BRAIN & DEVELOPMENT 17(5):317-321 NANBA E; KOHNO Y; MATSUDA A; YANO M; SATO C; et al. NONRADIOACTIVE DNA DIAGNOSIS FOR THE FRAGILE-X SYNDROME IN MENTALLY-RETARDED JAPANESE MALES	8	17
208	26	41	1368 1995 DEVELOPMENTAL BRAIN DYSFUNCTION 8(4-6):293-301 Jenkins EC; Houck GE; Ding XH; Li SY; StarkHouck SL; et al. An update on fragile X prenatal diagnosis: End of the cytogenetic testing era	1	1
209	26	49	1396 1995 HUMAN MOLECULAR GENETICS 4(1):45-49 DEGRAAFF E; ROUILLARD P; WILLEMS PJ; SMITS APT; ROUSSEAU F; et al. HOTSPOT FOR DELETIONS IN THE CGG REPEAT REGION OF FMR1 IN FRAGILE-X PATIENTS	31	46
210	26	59	1464 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):209-215 Chiurazzi P; Genuardi M; Kozak L; GiovannucciUzielli ML; Bussani C; et al. Fragile X founder chromosomes in Italy: A few initial events and possible explanation for their heterogeneity	17	26
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211	26	41	1587 1997 AMERICAN JOURNAL OF HUMAN GENETICS 60(1):103-112 FalikZaccai TC; Shachak E; Yalon M; Lis Z; Borochowitz Z; et al. Predisposition to the fragile X syndrome in Jews of Tunisian descent is due to the absence of AGG interruptions on a rare Mediterranean haplotype	17	27
212	26	38	1669 1997 HUMAN MUTATION 10(5):393-399 Wang YC; Lin ML; Lin SJ; Li YC; Li SY Novel point mutation within intron 10 of FMR-1 gene causing fragile X syndrome	7	10
213	26	47	1693 1997 MOLECULAR CELL 1(1):109-118 Feng Y; Absher D; Eberhart DE; Brown V; Malter HE; et al. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association	89	134
214	26	55	2021 2000 HUMAN MOLECULAR GENETICS 9(10):1487-1493 Tamanini F; Kirkpatrick LL; Schonkeren J; van Unen L; Bontekoe C; et al. The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins	9	14
215	26	47	2187 2001 NEUROPSYCHOLOGY 15(2):290-299 Bennetto L; Pennington BF; Porter D; Taylor AK; Hagerman RJ Profile of cognitive functioning in women with the fragile X mutation	10	13
216	26	36	2406 2003 BRAIN RESEARCH 972(1-2):9-15 Segal M; Kreher U; Greenberger V; Braun K Is fragile X mental retardation protein involved in activity-induced plasticity of dendritic spines?	0	1
217	26	61	2610 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(36):13357-13362 Khandjian EW; Huot ME; Tremblay S; Davidovic L; Mazroui R; et al. Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles	6	7
218	25	46	949 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):299-306 CLARKE A; BRADLEY D; GILLESPIE K; REES D; HOLLAND A; et al. FRAGILE-X MENTAL-RETARDATION AND THE IDURONATE SULFATASE LOCUS - TESTING LAIRD MODEL OF FRA(X) INHERITANCE	7	12
219	25	37	968 1992 ANNALS OF MEDICINE 24(6):453-456 POUSTKA A FRAGILE-X SYNDROME - MOLECULAR ANALYSIS REVEALS A NEW MECHANISM OF MUTATION IN HUMAN GENETIC-DISEASES	0	0
220	25	50	1125 1993 JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES 34(5):673-688 BAILEY A; BOLTON P; BUTLER L; LECOUTEUR A; MURPHY M; et al. PREVALENCE OF THE FRAGILE-X ANOMALY AMONGST AUTISTIC TWINS AND SINGLETONS	11	50
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221	25	47	2134 2001 CELL 107(4):477-487 Brown V; Jin P; Ceman S; Darnell JC; O'Donnell WT; et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome	80	162
222	25	49	2150 2001 GENETIC EPIDEMIOLOGY 20(1):129-144 Sharma D; Gupta M; Thelma BK Expansion mutation frequency and CGG/GCC repeat polymorphism in FMR1 and FMR2 genes in an Indian population	4	6
223	25	40	2192 2001 PEDIATRICS 108(5):art. no.-e88 Hessl D; Dyer-Friedman J; Glaser B; Wisbeck J; Barajas RG; et al. The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome	0	8
224	25	35	2315 2002 MICROSCOPY RESEARCH AND TECHNIQUE 57(3):174-178 Kau ASM; Meyer WA; Kaufmann WE Early development in males with fragile X syndrome: A review of the literature	2	3
225	25	40	2490 2004 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 129A(2):184-189 Zeesman S; Zwaigenbaum L; Whelan DT; Hagerman RJ; Tassone F; et al. Paternal transmission of fragile X syndrome	0	0
226	25	53	2611 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(42):15201-15206 Lu R; Wang HP; Liang Z; Ku L; O'Donnell WT; et al. The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development	3	3
227	25	61	2641 2005 MOLECULAR & CELLULAR PROTEOMICS 4(3):278-290 Zhang YQ; Friedman DB; Wang Z; Woodruff E; Pan LY; et al. Protein expression profiling of the Drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis	0	0
228	24	128	141 1983 INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY 81:107-143 SUTHERLAND GR THE FRAGILE X-CHROMOSOME	39	131
229	24	48	414 1986 TRENDS IN NEUROSCIENCES 9(2):58-62 PEMBREY ME; WINTER RM; DAVIES KE FRAGILE X MENTAL-RETARDATION - CURRENT CONTROVERSIES	7	9
230	24	44	700 1990 CLINICAL GENETICS 37(1):2-11 SUTHERLAND GR; MULLEY JC DIAGNOSTIC MOLECULAR-GENETICS OF THE FRAGILE-X	14	16
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231	24	65	712 1990 HUMAN GENETICS 85(6):659-665 WOHRLE D; FRYNS JP; STEINBACH P FRAGILE-X EXPRESSION AND FRAGILE-X INACTIVATION .1. THE EXPRESSION OF THE FRAGILE SITE AT XQ27.3 IS NOT SUPPRESSED ON INACTIVE X-CHROMOSOMES SEPARATED FROM THE ACTIVE HOMOLOG	7	9
232	24	53	883 1991 JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY 30(5):825-830 PIVEN J; GAYLE J; LANDA R; WZOREK M; FOLSTEIN S THE PREVALENCE OF FRAGILE-X IN A SAMPLE OF AUTISTIC INDIVIDUALS DIAGNOSED USING A STANDARDIZED INTERVIEW	7	26
233	24	31	914 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):5-27 MANDEL JL; HAGERMAN R; FROSTER U; BROWN WT; JENKINS EC; et al. 5TH INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION	5	8
234	24	29	1569 1996 PEDIATRICS 97(1):122-126 Hagerman RJ; Staley LW; OConner R; Lugenbeel K; Nelson D; et al. Learning-disabled males with a fragile X CGG expansion in the upper premutation size range	29	40
235	24	49	1574 1996 REVISTA MEDICA DE CHILE 124(7):865-872 Jara L; Avendano I; Aspillaga M; Blanco R Molecular and genetic features of fragile X syndrome. A review	0	0
236	24	61	1671 1997 JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS 27(4):415-435 Mazzocco MMM; Kates WR; Baumgardner TL; Freund LS; Reiss AL Autistic behaviors among girls with fragile X syndrome	20	25
237	24	69	1703 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(9):4587-4592 Hansen RS; Canfield TK; Fjeld AD; Mumm S; Laird CD; et al. A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication	8	41
238	24	39	1713 1998 AMERICAN JOURNAL OF MEDICAL GENETICS 75(3):277-282 Jara L; Aspillaga M; Avendano I; Obreque V; Blanco R; et al. Distribution of (CGG)n and FMR-1 associated microsatellite alleles in a normal Chilean population	6	7
239	24	41	1773 1998 JOURNAL OF INTELLECTUAL DISABILITY RESEARCH 42:81-89 Elbaz A; Suedois J; Duquesnoy M; Beldjord C; Berchel C; et al. Prevalence of fragile-X syndrome and FRAXE among children with intellectual disability in a Caribbean island, Guadeloupe, French West Indies	6	8
240	24	74	1926 1999 MOLECULAR AND CELLULAR BIOLOGY 19(8):5675-5684 White PJ; Borts RH; Hirst MC Stability of the human fragile X (CGG)(n) triplet repeat array in Saccharomyces cerevisiae deficient in aspects of DNA metabolism	12	45
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241	24	33	1969 2000 AMERICAN JOURNAL OF MEDICAL GENETICS 93(2):99-106 Larsen LA; Armstrong JSM; Gronskov K; Hjalgrim H; Macpherson JN; et al. Haplotype and AGG-interspersion analysis of FMR1 (CGG)(n) alleles in the Danish population: Implications for multiple mutational pathways towards fragile X alleles	4	6
242	24	79	1995 2000 CEREBRAL CORTEX 10(10):1038-1044 Irwin SA; Galvez R; Greenough WT Dendritic spine structural anomalies in fragile-X mental retardation syndrome	35	55
243	24	33	2001 2000 CLINICAL GENETICS 58(2):111-115 Kallinen J; Heinonen S; Mannermaa A; Ryynanen M Prenatal diagnosis of fragile X syndrome and the risk of expansion of a premutation	3	5
244	24	40	2011 2000 EXPERIMENTAL CELL RESEARCH 258(1):162-170 Bakker CE; Otero YD; Bontekoe C; Raghoe P; Luteijn T; et al. Immunocytochemical and biochemical characterization of FMRP, FXR1P, and FXR2P in the mouse	22	31
245	24	59	2326 2002 NEUROBIOLOGY OF DISEASE 11(1):221-229 Castren M; Lampinen KE; Miettinen R; Koponen E; Sipola I; et al. BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus	2	4
246	24	62	2416 2003 DEVELOPMENT 130(22):5543-5552 Lee A; Li WJ; Xu KY; Bogert BA; Su K; et al. Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1	10	15
247	24	41	2471 2003 PRENATAL DIAGNOSIS 23(4):345-351 Wald NJ; Morris JK A new approach to antenatal screening for Fragile X syndrome	1	3
248	24	59	2492 2004 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 129A(3):225-234 Kaufmann WE; Cortell R; Kau CSM; Bukelis I; Tierney E; et al. Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors	0	0
249	24	47	2508 2004 COGNITIVE NEUROPSYCHOLOGY 21(6):579-596 Keenan JM; Simon JA Inference deficits in women with Fragile X Syndrome: A problem in working memory	0	0
250	24	54	2574 2004 MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS 10(1):53-59 Beckel-Mitchener A; Greenough WT Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome	0	2
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
251	24	42	2601 2004 NEUROREPORT 15(16):2447-2450 Veneri M; Zalfa F; Bagni C FMRP and its target RNAs: fishing for the specificity	0	0
252	24	40	2603 2004 NUCLEIC ACIDS RESEARCH 32(7):2129-2137 Gabus C; Mazroui R; Tremblay S; Khandjian EW; Darlix JL The fragile X mental retardation protein has nucleic acid chaperone properties	2	5
253	24	45	2645 2005 NUCLEIC ACIDS RESEARCH 33(2):451-463 Napierala M; Michalowski D; de Mezer M; Krzyzosiak WJ Facile FMR1 mRNA structure regulation by interruptions in CGG repeats	0	0
254	23	47	457 1987 HUMAN GENETICS 75(4):311-321 BROWN WT; JENKINS EC; GROSS AC; CHAN CB; KRAWCZUN MS; et al. FURTHER EVIDENCE FOR GENETIC-HETEROGENEITY IN THE FRAGILE-X SYNDROME	33	54
255	23	48	982 1992 DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 34(9):826-832 GOLDSON E; HAGERMAN RJ THE FRAGILE-X SYNDROME	3	3
256	23	34	1003 1992 JOURNAL OF MEDICAL GENETICS 29(11):794-801 HEITZ D; DEVYS D; IMBERT G; KRETZ C; MANDEL JL INHERITANCE OF THE FRAGILE-X SYNDROME - SIZE OF THE FRAGILE-X PREMUTATION IS A MAJOR DETERMINANT OF THE TRANSITION TO FULL MUTATION	84	111
257	23	29	1033 1993 AMERICAN JOURNAL OF DISEASES OF CHILDREN 147(11):1231-1235 RAMOS FJ; EUNPU DL; FINUCANE B; PFENDNER EG DIRECT DNA TESTING FOR FRAGILE-X SYNDROME	1	2
258	23	47	1036 1993 AMERICAN JOURNAL OF HUMAN GENETICS 52(5):884-894 REISS AL; FREUND L; ABRAMS MT; BOEHM C; KAZAZIAN H NEUROBEHAVIORAL EFFECTS OF THE FRAGILE-X PREMUTATION IN ADULT WOMEN - A CONTROLLED-STUDY	73	98
259	23	41	1071 1993 AMERICAN JOURNAL OF HUMAN GENETICS 53(4):800-809 MCCONKIEROSELL A; LACHIEWICZ AM; SPIRIDIGLIOZZI GA; TARLETON J; SCHOENWALD S; et al. EVIDENCE THAT METHYLATION OF THE FMR-I LOCUS IS RESPONSIBLE FOR VARIABLE PHENOTYPIC-EXPRESSION OF THE FRAGILE-X SYNDROME	64	99
260	23	40	1124 1993 JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS 23(1):201-209 HASHIMOTO O; SHIMIZU Y; KAWASAKI Y LOW-FREQUENCY OF THE FRAGILE-X SYNDROME AMONG JAPANESE AUTISTIC SUBJECTS	3	8
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
261	23	46	1164 1993 PSYCHIATRIE DE L ENFANT 36(1):5-26 LIDAPULIK H; BASQUIN M COGNITIVE DISTURBANCES AND PSYCHIATRIC MANIFESTATIONS IN THE FRAGILE-X SYNDROME - AUTISM AND FRAGILE-X SYNDROME	0	1
262	23	52	1229 1994 CELL 78(1):23-33 BAKKER CE; VERHEIJ C; WILLEMSEN R; VANDERHELM R; OERLEMANS F; et al. FMR1 KNOCKOUT MICE - A MODEL TO STUDY FRAGILE-X MENTAL-RETARDATION	96	163
263	23	31	1241 1994 HUMAN MOLECULAR GENETICS 3(3):393-398 REISS AL; KAZAZIAN HH; KREBS CM; MCAUGHAN A; BOEHM CD; et al. FREQUENCY AND STABILITY OF THE FRAGILE-X PREMUTATION	34	61
264	23	41	1274 1994 NATURE GENETICS 8(1):88-94 EICHLER EE; HOLDEN JJA; POPOVICH BW; REISS AL; SNOW K; et al. LENGTH OF UNINTERRUPTED CGG REPEATS DETERMINES INSTABILITY IN THE FMR1 GENE	92	243
265	23	37	1408 1995 JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 17(4):518-528 HINTON VJ; HALPERIN JM; DOBKIN CS; DING XH; BROWN WT; et al. COGNITIVE AND MOLECULAR ASPECTS OF FRAGILE-X	5	9
266	23	35	1436 1995 PRENATAL DIAGNOSIS 15(9):801-807 CASTELLVIBEL S; MILA M; SOLER A; CARRIO A; SANCHEZ A; et al. PRENATAL-DIAGNOSIS OF FRAGILE-X SYNDROME - (CGG)(N) EXPANSION AND METHYLATION OF CHORIONIC VILLUS SAMPLES	2	6
267	23	45	1465 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):220-225 Eichler EE; Nelson DL Genetic variation and evolutionary stability of the FMR1 CGG repeat in six closed human populations	14	18
268	23	35	1476 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(2):287-292 Brown WT; Houck GE; Ding XH; Zhong N; Nolin S; et al. Reverse mutations in the fragile X syndrome	11	18
269	23	59	1689 1997 JOURNAL OF NEUROSCIENCE 17(5):1539-1547 Feng Y; Gutekunst CA; Eberhart DE; Yi H; Warren ST; et al. Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes	85	145
270	23	44	1706 1997 PSYCHIATRIC GENETICS 7(3):115-119 ODwyer J; Holmes J; Mueller R; Taylor G The prevalence of Fragile-X syndrome in an institution for people with learning disability	1	3
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
271	23	30	1741 1998 EUROPEAN JOURNAL OF HUMAN GENETICS 6(5):518-522 Peixoto A; dos Santos MR; Seruca R; Amorim A; Castedo S Analysis of FMR1 and flanking microsatellite markers in normal and fragile X chromosomes in Portugal: evidence for a "protector" haplotype	2	2
272	23	62	1746 1998 GENOMICS 50(2):229-240 Lavedan C; Grabczyk E; Usdin K; Nussbaum RL Long uninterrupted CGG repeats within the first exon of the human FMR1 gene are not intrinsically unstable in transgenic mice	17	21
273	23	41	1748 1998 HUMAN GENETICS 102(4):440-445 Gronskov K; Hallberg A; Brondum-Nielsen K Mutational analysis of the FMR1 gene in 118 mentally retarded males suspected of fragile X syndrome: absence of prevalent mutations	4	8
274	23	38	1996 2000 CEREBRAL CORTEX 10(10):1045-1052 Braun K; Segal M FMRP involvement in formation of synapses among cultured hippocampal neurons	21	23
275	23	46	2004 2000 DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 42(11):768-774 Sheldon L; Turk J Monozygotic boys with fragile X syndrome	1	2
276	23	55	2123 2001 AMERICAN JOURNAL ON MENTAL RETARDATION 106(3):216-230 Roberts JE; Mirrett P; Burchinal M Receptive and expressive communication development of young males with fragile X syndrome	6	10
277	23	34	2138 2001 CELLULAR AND MOLECULAR NEUROBIOLOGY 21(1):29-38 Castren M; Haapasalo A; Oostra BA; Castren E Subcellular localization of fragile X mental retardation protein with the I304N mutation in the RNA-binding domain in cultured hippocampal neurons	3	3
278	23	64	2159 2001 HUMAN MOLECULAR GENETICS 10(24):2803-2811 Huot ME; Mazroui R; Leclerc P; Khandjian EW Developmental expression of the fragile X-related 1 proteins in mouse testis: association with microtubule elements	5	7
279	23	53	2318 2002 MOLECULAR AND CELLULAR BIOLOGY 22(24):8438-8447 Siomi MC; Higashijima K; Ishizuka A; Siomi H Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties	14	16
280	23	75	2319 2002 MOLECULAR AND CELLULAR NEUROSCIENCE 19(2):138-151 Li JX; Pelletier MR; Velazquez JLP; Carlen PL Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency	18	20
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
281	23	52	2342 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15758-15763 Qin M; Kang J; Smith CB Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation	5	6
282	23	62	2404 2003 BMC MOLECULAR BIOLOGY 4 Chandler SP; Kansagra P; Hirst MC Fragile X (CGG)(n) repeats induce a transcriptional repression in cis upon a linked promoter: Evidence for a chromatin mediated effect	0	3
283	23	44	2430 2003 HUMAN MOLECULAR GENETICS 12(23):3067-3074 Chen LS; Tassone F; Sahota P; Hagerman PJ The (CGG)(n) repeat element within the 5 ' untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter	3	3
284	23	69	2455 2003 LANGUAGE SPEECH AND HEARING SERVICES IN SCHOOLS 34(4):320-331 Mirrett PL; Roberts JE Early intervention practices and communication intervention strategies for young males with fragile X syndrome	0	0
285	23	40	2502 2004 BRAIN 127:2672-2681 Moore CJ; Daly EM; Tassone F; Tysoe C; Schmitz N; et al. The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy	0	0
286	23	34	2561 2004 JOURNAL OF NEUROSCIENCE 24(33):7272-7276 Stefani G; Fraser CE; Darnell JC; Darnell RB Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells	2	3
287	23	68	2634 2005 HUMAN MOLECULAR GENETICS 14(6):835-844 Castets M; Schaeffer C; Bechara E; Schenck A; Khandjian EW; et al. FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts	0	0
288	23	47	2638 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280(7):5750-5763 Garnon J; Lachance C; Di Marco S; Hel Z; Marion D; et al. Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level	0	0
289	22	61	531 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):355-368 MCKINLEY MJ; KEARNEY LU; NICOLAIDES KH; GOSDEN CM; WEBB TP; et al. PRENATAL-DIAGNOSIS OF FRAGILE-X SYNDROME BY PLACENTAL (CHORIONIC VILLI) BIOPSY CULTURE	8	13
290	22	49	741 1991 AMERICAN JOURNAL OF HUMAN GENETICS 48(2):195-202 COHEN IL; SUDHALTER V; PFADT A; JENKINS EC; BROWN WT; et al. WHY ARE AUTISM AND THE FRAGILE-X SYNDROME ASSOCIATED - CONCEPTUAL AND METHODOLOGICAL ISSUES	34	65
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
291	22	34	1073 1993 AMERICAN JOURNAL OF HUMAN GENETICS 53(6):1217-1228 SNOW K; DOUD LK; HAGERMAN R; PERGOLIZZI RG; ERSTER SH; et al. ANALYSIS OF A CGG SEQUENCE AT THE FMR-I LOCUS IN FRAGILE-X FAMILIES AND IN THE GENERAL-POPULATION	102	140
292	22	25	1133 1993 JOURNAL OF MEDICAL GENETICS 30(5):410-413 OOSTRA BA; JACKY PB; BROWN WT; ROUSSEAU F GUIDELINES FOR THE DIAGNOSIS OF FRAGILE-X SYNDROME	49	61
293	22	51	1138 1993 JOURNAL OF PEDIATRICS 122(2):169-185 TARLETON JC; SAUL RA MOLECULAR GENETIC ADVANCES IN FRAGILE X-SYNDROME	14	28
294	22	61	1276 1994 NEUROLOGY 44(7):1317-1324 REISS AL; LEE J; FREUND L NEUROANATOMY OF FRAGILE-X SYNDROME - THE TEMPORAL-LOBE	54	89
295	22	31	1486 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(2):350-355 WrightTalamante C; Cheema A; Riddle JE; Luckey DW; Taylor AK; et al. A controlled study of longitudinal IQ changes in females and males with fragile X syndrome	14	16
296	22	35	1588 1997 AMERICAN JOURNAL OF HUMAN GENETICS 61(3):660-667 deVries BBA; vandenOuweland AMW; Mohkamsing S; Duivenvoorden HJ; Mol E; et al. Screening and diagnosis for the fragile X syndrome among the mentally retarded: An epidemiological and psychological survey	44	80
297	22	25	1625 1997 AMERICAN JOURNAL OF MEDICAL GENETICS 72(4):430-434 Hammond LS; Macias MM; Tarleton JC; Pai GS Fragile X syndrome and deletions in FMR1: New case and review of the literature	15	22
298	22	32	1630 1997 ANNALES DE GENETIQUE 40(3):139-144 Gerard B; LeHeuzey MF; Brunie G; Lewine P; Saiag MC; et al. Systematic screening for fragile X syndrome in a cohort of 574 mentally retarded children	4	8
299	22	35	1666 1997 HUMAN MOLECULAR GENETICS 6(7):971-979 Moutou C; Vincent MC; Biancalana V; Mandel JL Transition from premutation to full mutation in fragile X syndrome is likely to be prezygotic	23	34
300	22	42	1695 1997 NATURE GENETICS 15(2):165-169 Malter HE; Iber JC; Willemsen R; deGraaff E; Tarleton JC; et al. Characterization of the full fragile X syndrome mutation in fetal gametes	58	89

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