HistCite - index: Fragile X

Tue Aug 24 10:42:29 2004

All papers with "Fragile X" in the title.

Nodes: 2369
Authors: 4634, Journals: 373, Outer References: 14152
Collection span: 1980 - 2004
View: Overview. Sorted by LCS.
Page 1: 1 (501) 2 (47) 3 (27) 4 (19) 5 (14) 6 (11) 7 (8) 8 (6) 9 (5) 10 (4) 11 (3) 12 (2) 13 (1) 14 (1) 15 (1) 16 (0) 17 (0) 18 (0) 19 (0) 20 (0) 21 (0) 22 (0) 23 (0) 24 (0)

# LCR NCR Nodes / Date / Journal / Authors LCS GCS
1 11 40 839 1991 CELL 65(5):905-914
VERKERK AJMH; PIERETTI M; SUTCLIFFE JS; FU YH; KUHL DPA; PIZZUTI A; REINER O; RICHARDS S; VICTORIA MF; ZHANG FP; EUSSEN BE; VANOMMEN GJB; BLONDEN LAJ; RIGGINS GJ; CHASTAIN JL; KUNST CB; GALJAARD H; CASKEY CT; NELSON DL; OOSTRA BA; WARREN ST
IDENTIFICATION OF A GENE (FMR-1) CONTAINING A CGG REPEAT COINCIDENT WITH A BREAKPOINT CLUSTER REGION EXHIBITING LENGTH VARIATION IN FRAGILE-X SYNDROME
501 1246
2 18 37 897 1991 SCIENCE 252(5009):1097-1102
OBERLE I; ROUSSEAU F; HEITZ D; KRETZ C; DEVYS D; HANAUER A; BOUE J; BERTHEAS MF; MANDEL JL
INSTABILITY OF A 550 BASE PAIR DNA SEGMENT AND ABNORMAL METHYLATION IN FRAGILE X-SYNDROME
394 835
3 12 23 841 1991 CELL 67(6):1047-1058
FU YH; KUHL DPA; PIZZUTI A; PIERETTI M; SUTCLIFFE JS; RICHARDS S; VERKERK AJMH; HOLDEN JJA; FENWICK RG; WARREN ST; OOSTRA BA; NELSON DL; CASKEY CT
VARIATION OF THE CGG REPEAT AT THE FRAGILE-X SITE RESULTS IN GENETIC INSTABILITY - RESOLUTION OF THE SHERMAN PARADOX
368 933
4 10 15 840 1991 CELL 66(4):817-822
PIERETTI M; ZHANG FP; FU YH; WARREN ST; OOSTRA BA; CASKEY CT; NELSON DL
ABSENCE OF EXPRESSION OF THE FMR-1 GENE IN FRAGILE-X SYNDROME
291 583
5 3 9 898 1991 SCIENCE 252(5009):1179-1181
YU S; PRITCHARD M; KREMER E; LYNCH M; NANCARROW J; BAKER E; HOLMAN K; MULLEY JC; WARREN ST; SCHLESSINGER D; SUTHERLAND GR; RICHARDS RI
FRAGILE-X GENOTYPE CHARACTERIZED BY AN UNSTABLE REGION OF DNA
274 537
6 15 28 885 1991 NEW ENGLAND JOURNAL OF MEDICINE 325(24):1673-1681
ROUSSEAU F; HEITZ D; BIANCALANA V; BLUMENFELD S; KRETZ C; BOUE J; TOMMERUP N; VANDERHAGEN C; DELOZIERBLANCHET C; CROQUETTE MF; GILGENKRANTZ S; JALBERT P; VOELCKEL MA; OBERLE I; MANDEL JL
DIRECT DIAGNOSIS BY DNA ANALYSIS OF THE FRAGILE X-SYNDROME OF MENTAL-RETARDATION
268 438
7 11 40 285 1985 HUMAN GENETICS 69(4):289-299
SHERMAN SL; JACOBS PA; MORTON NE; FROSTERISKENIUS U; HOWARDPEEBLES PN; NIELSEN KB; PARTINGTON MW; SUTHERLAND GR; TURNER G; WATSON M
FURTHER SEGREGATION ANALYSIS OF THE FRAGILE-X SYNDROME WITH SPECIAL REFERENCE TO TRANSMITTING MALES
226 348
8 5 13 899 1991 SCIENCE 252(5013):1711-1714
KREMER EJ; PRITCHARD M; LYNCH M; YU S; HOLMAN K; BAKER E; WARREN ST; SCHLESSINGER D; SUTHERLAND GR; RICHARDS RI
MAPPING OF DNA INSTABILITY AT THE FRAGILE-X TO A TRINUCLEOTIDE REPEAT SEQUENCE P(CCG)N
200 575
9 19 36 1138 1993 NATURE GENETICS 4(4):335-340
DEVYS D; LUTZ Y; ROUYER N; BELLOCQ JP; MANDEL JL
THE FMR-1 PROTEIN IS CYTOPLASMIC, MOST ABUNDANT IN NEURONS AND APPEARS NORMAL IN CARRIERS OF A FRAGILE X PREMUTATION
169 277
10 11 12 1412 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):196-197
Turner G; Webb T; Wake S; Robinson H
Prevalence of fragile X syndrome
137 223
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
11 16 27 1133 1993 NATURE GENETICS 3(1):31-35
DEBOULLE K; VERKERK AJMH; REYNIERS E; VITS L; HENDRICKX J; VANROY B; VANDENBOS F; DEGRAAFF E; OOSTRA BA; WILLEMS PJ
A POINT MUTATION IN THE FMR-1 GENE ASSOCIATED WITH FRAGILE-X MENTAL-RETARDATION
131 262
12 30 38 1151 1994 AMERICAN JOURNAL OF HUMAN GENETICS 55(2):225-237
ROUSSEAU F; HEITZ D; TARLETON J; MACPHERSON J; MALMGREN H; DAHL N; BARNICOAT A; MATHEW C; MORNET E; TEJADA I; MADDALENA A; SPIEGEL R; SCHINZEL A; MARCOS JAG; SCHORDERET DF; SCHAAP T; MACCIONI L; RUSSO S; JACOBS PA; SCHWARTZ C; MANDEL JL
A MULTICENTER STUDY ON GENOTYPE-PHENOTYPE CORRELATIONS IN THE FRAGILE-X-SYNDROME, USING DIRECT DIAGNOSIS WITH PROBE STB-12.3 - THE FIRST 2,253 CASES
119 165
13 9 34 838 1991 CELL 64(4):861-866
BELL MV; HIRST MC; NAKAHORI Y; MACKINNON RN; ROCHE A; FLINT TJ; JACOBS PA; TOMMERUP N; TRANEBJAERG L; FROSTERISKENIUS U; KERR B; TURNER G; LINDENBAUM RH; WINTER R; PEMBREY M; THIBODEAU S; DAVIES KE
PHYSICAL MAPPING ACROSS THE FRAGILE-X - HYPERMETHYLATION AND CLINICAL EXPRESSION OF THE FRAGILE-X SYNDROME
118 222
14 15 56 1076 1993 CELL 74(2):291-298
SIOMI H; SIOMI MC; NUSSBAUM RL; DREYFUSS G
THE PROTEIN PRODUCT OF THE FRAGILE-X GENE, FMR1, HAS CHARACTERISTICS OF AN RNA-BINDING PROTEIN
117 315
15 10 29 1626 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(10):5401-5404
Comery TA; Harris JB; Willems PJ; Oostra BA; Irwin SA; Weiler IJ; Greenough WT
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
111 201
16 11 14 882 1991 NATURE 349(6310):624-626
VINCENT A; HEITZ D; PETIT C; KRETZ C; OBERLE I; MANDEL JL
ABNORMAL PATTERN DETECTED IN FRAGILE-X PATIENTS BY PULSED-FIELD GEL-ELECTROPHORESIS
105 164
17 20 55 1105 1993 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 270(13):1569-1575
BROWN WT; HOUCK GE; JEZIOROWSKA A; LEVINSON FN; DING XH; DOBKIN C; ZHONG N; HENDERSON J; BROOKS SS; JENKINS EC
RAPID FRAGILE-X CARRIER SCREENING AND PRENATAL-DIAGNOSIS USING A NONRADIOACTIVE PCR TEST
103 154
18 8 17 1132 1993 NATURE 363(6431):722-724
VERHEIJ C; BAKKER CE; DEGRAAFF E; KEULEMANS J; WILLEMSEN R; VERKERK AJMH; GALJAARD H; REUSER AJJ; HOOGEVEEN AT; OOSTRA BA
CHARACTERIZATION AND LOCALIZATION OF THE FMR-1 GENE-PRODUCT ASSOCIATED WITH FRAGILE-X SYNDROME
103 182
19 1 6 404 1986 NEW ENGLAND JOURNAL OF MEDICINE 315(10):607-609
TURNER G; ROBINSON H; LAING S; PURVISSMITH S
PREVENTIVE SCREENING FOR THE FRAGILE-X SYNDROME
95 123
20 15 30 901 1992 AMERICAN JOURNAL OF HUMAN GENETICS 50(5):968-980
YU S; MULLEY J; LOESCH D; TURNER G; DONNELLY A; GEDEON A; HILLEN D; KREMER E; LYNCH M; PRITCHARD M; SUTHERLAND GR; RICHARDS RI
FRAGILE-X SYNDROME - UNIQUE GENETICS OF THE HERITABLE UNSTABLE ELEMENT
93 174
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
21 15 42 447 1987 GENETICS 117(3):587-599
LAIRD CD
PROPOSED MECHANISM OF INHERITANCE AND EXPRESSION OF THE HUMAN FRAGILE-X SYNDROME OF MENTAL-RETARDATION
92 167
22 20 33 1134 1993 NATURE GENETICS 3(1):36-43
HINDS HL; ASHLEY CT; SUTCLIFFE JS; NELSON DL; WARREN ST; HOUSMAN DE; SCHALLING M
TISSUE SPECIFIC EXPRESSION OF FMR-1 PROVIDES EVIDENCE FOR A FUNCTIONAL-ROLE IN FRAGILE-X SYNDROME
91 154
23 9 33 895 1991 SCIENCE 251(4998):1236-1239
HEITZ D; ROUSSEAU F; DEVYS D; SACCONE S; ABDERRAHIM H; LEPASLIER D; COHEN D; VINCENT A; TONIOLO D; DELLAVALLE G; JOHNSON S; SCHLESSINGER D; OBERLE I; MANDEL JL
ISOLATION OF SEQUENCES THAT SPAN THE FRAGILE-X AND IDENTIFICATION OF A FRAGILE-X RELATED CPG ISLAND
86 139
24 16 58 1625 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(10):5395-5400
Weiler IJ; Irwin SA; Klintsova AY; Spencer CM; Brazelton AD; Miyashiro K; Comery TA; Patel B; Eberwine J; Greenough WT
Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation
86 174
25 22 34 1058 1993 AMERICAN JOURNAL OF HUMAN GENETICS 53(6):1217-1228
SNOW K; DOUD LK; HAGERMAN R; PERGOLIZZI RG; ERSTER SH; THIBODEAU SN
ANALYSIS OF A CGG SEQUENCE AT THE FMR-I LOCUS IN FRAGILE-X FAMILIES AND IN THE GENERAL-POPULATION
84 136
26 12 32 246 1985 AMERICAN JOURNAL OF MEDICAL GENETICS 21(4):709-717
PEMBREY ME; WINTER RM; DAVIES KE
A PRE-MUTATION THAT GENERATES A DEFECT AT CROSSING OVER EXPLAINS THE INHERITANCE OF FRAGILE X MENTAL RETARDATION
82 116
27 10 23 1009 1992 NATURE GENETICS 1(5):341-344
GEDEON AK; BAKER E; ROBINSON H; PARTINGTON MW; GROSS B; MANCA A; KORN B; POUSTKA A; YU S; SUTHERLAND GR; MULLEY JC
FRAGILE-X SYNDROME WITHOUT CCG AMPLIFICATION HAS AN FMR1 DELETION
82 137
28 28 44 1137 1993 NATURE GENETICS 4(2):143-146
REYNIERS E; VITS L; DEBOULLE K; VANROY B; VANVELZEN D; DEGRAAFF E; VERKERK AJMH; JORENS HZJ; DARBY JK; OOSTRA B; WILLEMS PJ
THE FULL MUTATION IN THE FMR-1 GENE OF MALE FRAGILE-X PATIENTS IS ABSENT IN THEIR SPERM
82 167
29 8 33 153 1983 NATURE 306(5944):701-704
CAMERINO G; MATTEI MG; MATTEI JF; JAYE M; MANDEL JL
CLOSE LINKAGE OF FRAGILE X MENTAL-RETARDATION SYNDROME TO HEMOPHILIA-B AND TRANSMISSION THROUGH A NORMAL-MALE
78 171
30 22 52 1208 1994 CELL 78(1):23-33
BAKKER CE; VERHEIJ C; WILLEMSEN R; VANDERHELM R; OERLEMANS F; VERMEY M; BYGRAVE A; HOOGEVEEN AT; OOSTRA BA; REYNIERS E; DEBOULLE K; DHOOGE R; CRAS P; VANVELZEN D; NAGELS G; MARTIN JJ; DEDEYN PP; DARBY JK; WILLEMS PJ
FMR1 KNOCKOUT MICE - A MODEL TO STUDY FRAGILE-X MENTAL-RETARDATION
78 147
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
31 33 42 1291 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(5):1006-1018
ROUSSEAU F; ROUILLARD P; MOREL ML; KHANDJIAN EW; MORGAN K
PREVALENCE OF CARRIERS OF PREMUTATION-SIZE ALLELES OF THE FMRI GENE AND IMPLICATIONS FOR THE POPULATION-GENETICS OF THE FRAGILE-X SYNDROME
78 105
32 5 23 69 1982 JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS 12(3):303-308
BROWN WT; JENKINS EC; FRIEDMAN E; BROOKS J; WISNIEWSKI K; RAGUTHU S; FRENCH J
AUTISM IS ASSOCIATED WITH THE FRAGILE-X SYNDROME
77 121
33 5 26 319 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):157-169
FRYNS JP
THE FEMALE AND THE FRAGILE-X - A STUDY OF 144 OBLIGATE FEMALE CARRIERS
76 101
34 10 39 831 1991 AMERICAN JOURNAL OF MEDICAL GENETICS 41(3):289-294
HINTON VJ; BROWN WT; WISNIEWSKI K; RUDELLI RD
ANALYSIS OF NEOCORTEX IN 3 MALES WITH THE FRAGILE-X SYNDROME
76 117
35 30 48 1226 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):507-514
TAYLOR AK; SAFANDA JF; FALL MZ; QUINCE C; LANG KA; HULL CE; CARPENTER I; STALEY LW; HAGERMAN RJ
MOLECULAR PREDICTORS OF COGNITIVE INVOLVEMENT IN FEMALE CARRIERS OF FRAGILE-X SYNDROME
76 89
36 13 42 334 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):359-374
HAGERMAN RJ; JACKSON AW; LEVITAS A; RIMLAND B; BRADEN M
AN ANALYSIS OF AUTISM IN 50 MALES WITH THE FRAGILE-X SYNDROME
74 104
37 17 53 1485 1996 HUMAN MOLECULAR GENETICS 5(8):1083-1091
Eberhart DE; Malter HE; Feng Y; Warren ST
The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
74 120
38 18 23 903 1992 AMERICAN JOURNAL OF HUMAN GENETICS 51(2):299-306
WOHRLE D; KOTZOT D; HIRST MC; MANCA A; KORN B; SCHMIDT A; BARBI G; ROTT HD; POUSTKA A; DAVIES KE; STEINBACH P
A MICRODELETION OF LESS THAN 250 KB, INCLUDING THE PROXIMAL PART OF THE FMR-I GENE AND THE FRAGILE-X SITE, IN A MALE WITH THE CLINICAL PHENOTYPE OF FRAGILE-X SYNDROME
73 121
39 8 9 1377 1995 LANCET 345(8958):1147-1148
WILLEMSEN R; MOHKAMSING S; DEVRIES B; DEVYS D; VANDENOUWELAND A; MANDEL JL; GALJAARD H; OOSTRA B
RAPID ANTIBODY-TEST FOR FRAGILE-X SYNDROME
73 94
40 23 34 994 1992 JOURNAL OF MEDICAL GENETICS 29(11):794-801
HEITZ D; DEVYS D; IMBERT G; KRETZ C; MANDEL JL
INHERITANCE OF THE FRAGILE-X SYNDROME - SIZE OF THE FRAGILE-X PREMUTATION IS A MAJOR DETERMINANT OF THE TRANSITION TO FULL MUTATION
72 108
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
41 7 52 235 1985 ACTA NEUROPATHOLOGICA 67(3-4):289-295
RUDELLI RD; BROWN WT; WISNIEWSKI K; JENKINS EC; LAUREKAMIONOWSKA M; CONNELL F; WISNIEWSKI HM
ADULT FRAGILE X-SYNDROME - CLINICO-NEUROPATHOLOGIC FINDINGS
71 110
42 23 59 1613 1997 JOURNAL OF NEUROSCIENCE 17(5):1539-1547
Feng Y; Gutekunst CA; Eberhart DE; Yi H; Warren ST; Hersch SM
Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes
71 131
43 18 51 332 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):341-352
BROWN WT; JENKINS EC; COHEN IL; FISCH GS; WOLFSCHEIN EG; GROSS A; WATERHOUSE L; FEIN D; MASONBROTHERS A; RITVO E; RUTTENBERG BA; BENTLEY W; CASTELLS S
FRAGILE-X AND AUTISM - A MULTICENTER SURVEY
70 108
44 23 47 1026 1993 AMERICAN JOURNAL OF HUMAN GENETICS 52(5):884-894
REISS AL; FREUND L; ABRAMS MT; BOEHM C; KAZAZIAN H
NEUROBEHAVIORAL EFFECTS OF THE FRAGILE-X PREMUTATION IN ADULT WOMEN - A CONTROLLED-STUDY
70 95
45 20 53 1207 1994 CELL 77(6):853-861
KUNST CB; WARREN ST
CRYPTIC AND POLAR VARIATION OF THE FRAGILE-X REPEAT COULD RESULT IN PREDISPOSING NORMAL ALLELES
70 239
46 8 20 1008 1992 NATURE GENETICS 1(4):257-260
RICHARDS RI; HOLMAN K; FRIEND K; KREMER E; HILLEN D; STAPLES A; BROWN WT; GOONEWARDENA P; TARLETON J; SCHWARTZ C; SUTHERLAND GR
EVIDENCE OF FOUNDER CHROMOSOMES IN FRAGILE-X SYNDROME
69 158
47 4 11 393 1986 JOURNAL OF MEDICAL GENETICS 23(5):396-399
WEBB TP; BUNDEY S; THAKE A; TODD J
THE FREQUENCY OF THE FRAGILE X-CHROMOSOME AMONG SCHOOLCHILDREN IN COVENTRY
68 105
48 14 37 1110 1993 JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 14(5):328-335
MAZZOCCO MMM; PENNINGTON BF; HAGERMAN RJ
THE NEUROCOGNITIVE PHENOTYPE OF FEMALE CARRIERS OF FRAGILE-X - ADDITIONAL EVIDENCE FOR SPECIFICITY
68 87
49 38 61 1155 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):298-308
HAGERMAN RJ; HULL CE; SAFANDA JF; CARPENTER I; STALEY LW; OCONNOR RA; SEYDEL C; MAZZOCCO MMM; SNOW K; THIBODEAU SN; KUHL D; NELSON DL; CASKEY CT; TAYLOR AK
HIGH FUNCTIONING FRAGILE-X MALES - DEMONSTRATION OF AN UNMETHYLATED FULLY EXPANDED FMR-1 MUTATION ASSOCIATED WITH PROTEIN EXPRESSION
67 95
50 24 47 1617 1997 MOLECULAR CELL 1(1):109-118
Feng Y; Absher D; Eberhart DE; Brown V; Malter HE; Warren ST
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association
65 114
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
51 15 39 1206 1994 CELL 77(1):33-39
SIOMI H; CHOI MY; SIOMI MC; NUSSBAUM RL; DREYFUSS G
ESSENTIAL ROLE FOR KH DOMAINS IN RNA-BINDING - IMPAIRED RNA-BINDING BY A MUTATION IN THE KH DOMAIN OF FMR1 THAT CAUSES FRAGILE-X SYNDROME
64 254
52 38 118 362 1986 ANNUAL REVIEW OF GENETICS 20:109-145
NUSSBAUM RL; LEDBETTER DH
FRAGILE-X SYNDROME - A UNIQUE MUTATION IN MAN
63 112
53 23 41 1056 1993 AMERICAN JOURNAL OF HUMAN GENETICS 53(4):800-809
MCCONKIEROSELL A; LACHIEWICZ AM; SPIRIDIGLIOZZI GA; TARLETON J; SCHOENWALD S; PHELAN MC; GOONEWARDENA P; DING XH; BROWN WT
EVIDENCE THAT METHYLATION OF THE FMR-I LOCUS IS RESPONSIBLE FOR VARIABLE PHENOTYPIC-EXPRESSION OF THE FRAGILE-X SYNDROME
63 99
54 16 36 1347 1995 EMBO JOURNAL 14(21):5358-5366
ZHANG Y; OCONNOR JP; SIOMI MC; SRINIVASAN S; DUTRA A; NUSSBAUM RL; DREYFUSS G
THE FRAGILE-X MENTAL-RETARDATION SYNDROME PROTEIN INTERACTS WITH NOVEL HOMOLOGS FXR1 AND FXR2
63 111
55 11 20 873 1991 JOURNAL OF MEDICAL GENETICS 28(12):830-836
ROUSSEAU F; HEITZ D; OBERLE I; MANDEL JL
SELECTION IN BLOOD-CELLS FROM FEMALE CARRIERS OF THE FRAGILE-X SYNDROME - INVERSE CORRELATION BETWEEN AGE AND PROPORTION OF ACTIVE X-CHROMOSOMES CARRYING THE FULL MUTATION
62 84
56 6 11 886 1991 NEW ENGLAND JOURNAL OF MEDICINE 325(24):1720-1722
SUTHERLAND GR; GEDEON A; KORNMAN L; DONNELLY A; BYARD RW; MULLEY JC; KREMER E; LYNCH M; PRITCHARD M; YU S; RICHARDS RI
PRENATAL-DIAGNOSIS OF FRAGILE X-SYNDROME BY DIRECT DETECTION OF THE UNSTABLE DNA-SEQUENCE
61 86
57 10 20 890 1991 NUCLEIC ACIDS RESEARCH 19(16):4355-4359
NAKAHORI Y; KNIGHT SJL; HOLLAND J; SCHWARTZ C; ROCHE A; TARLETON J; WONG S; FLINT TJ; FROSTERISKENIUS U; BENTLEY D; DAVIES KE; HIRST MC
MOLECULAR HETEROGENEITY OF THE FRAGILE-X SYNDROME
61 91
58 41 81 1227 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):536-542
WARREN ST; NELSON DL
ADVANCES IN MOLECULAR ANALYSIS OF FRAGILE-X SYNDROME
59 125
59 10 15 933 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):208-216
DEVYS D; BIANCALANA V; ROUSSEAU F; BOUE J; MANDEL JL; OBERLE I
ANALYSIS OF FULL FRAGILE-X MUTATIONS IN FETAL TISSUES AND MONOZYGOTIC TWINS INDICATE THAT ABNORMAL METHYLATION AND SOMATIC HETEROGENEITY ARE ESTABLISHED EARLY IN DEVELOPMENT
58 89
60 19 23 1136 1993 NATURE GENETICS 4(2):140-142
WOHRLE D; HENNIG I; VOGEL W; STEINBACH P
MITOTIC STABILITY OF FRAGILE-X MUTATIONS IN DIFFERENTIATED CELLS INDICATES EARLY POSTCONCEPTIONAL TRINUCLEOTIDE REPEAT EXPANSION
58 120
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
61 10 31 1503 1996 NATURE GENETICS 12(1):91-93
Khandjian EW; Corbin F; Woerly S; Rousseau F
The fragile X mental retardation protein is associated with ribosomes
58 93
62 21 31 1011 1992 PEDIATRICS 89(3):395-400
HAGERMAN RJ; JACKSON C; AMIRI K; SILVERMAN AC; OCONNOR R; SOBESKY W
GIRLS WITH FRAGILE-X SYNDROME - PHYSICAL AND NEUROCOGNITIVE STATUS AND OUTCOME
57 79
63 1 4 28 1981 LANCET 2(8258):1292-1292
JENKINS EC; BROWN WT; DUNCAN CJ; BROOKS J; BENYISHAY M; GIORDANO FM; NITOWSKY HM
FEASIBILITY OF FRAGILE X-CHROMOSOME PRENATAL-DIAGNOSIS DEMONSTRATED
56 77
64 8 32 105 1983 AMERICAN JOURNAL OF MEDICAL GENETICS 14(4):699-712
CHUDLEY AE; KNOLL J; GERRARD JW; SHEPEL L; MCGAHEY E; ANDERSON J
FRAGILE (X) X-LINKED MENTAL-RETARDATION .1. RELATIONSHIP BETWEEN AGE AND INTELLIGENCE AND THE FREQUENCY OF EXPRESSION OF FRAGILE (X)(Q28)
56 80
65 0 3 191 1984 CLINICAL GENETICS 25(2):131-134
FRYNS JP; JACOBS J; KLECZKOWSKA A; VANDENBERGHE H
THE PSYCHOLOGICAL PROFILE OF THE FRAGILE X-SYNDROME
56 75
66 7 32 560 1988 ARCHIVES OF GENERAL PSYCHIATRY 45(1):25-30
REISS AL; HAGERMAN RJ; VINOGRADOV S; ABRAMS M; KING RJ
PSYCHIATRIC DISABILITY IN FEMALE CARRIERS OF THE FRAGILE X-CHROMOSOME
56 91
67 13 27 519 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):191-200
KEMPER MB; HAGERMAN RJ; ALTSHULSTARK D
COGNITIVE PROFILES OF BOYS WITH THE FRAGILE-X SYNDROME
55 73
68 12 38 1595 1997 HUMAN MOLECULAR GENETICS 6(9):1465-1472
Corbin F; Bouillon M; Fortin A; Morin S; Rousseau F; Khandjian EW
The fragile X mental retardation protein is associated with poly(A)(+) mRNA in actively translating polyribosomes
55 85
69 19 31 2023 2001 HUMAN MOLECULAR GENETICS 10(4):329-338
Laggerbauer B; Ostareck D; Keidel EM; Ostareck-Lederer A; Fischer U
Evidence that fragile X mental retardation protein is a negative regulator of translation
55 80
70 9 24 238 1985 AMERICAN JOURNAL OF DISEASES OF CHILDREN 139(7):674-678
HAGERMAN R; KEMPER M; HUDSON M
LEARNING-DISABILITIES AND ATTENTIONAL PROBLEMS IN BOYS WITH THE FRAGILE X-SYNDROME
54 71
# LCR NCR Nodes / Date / Journal / Authors LCS GCS
71 4 31 833 1991 ANNALS OF NEUROLOGY 29(1):26-32
REISS AL; AYLWARD E; FREUND LS; JOSHI PK; BRYAN RN
NEUROANATOMY OF FRAGILE-X-SYNDROME - THE POSTERIOR-FOSSA
54 110
72 20 37 1143 1993 PEDIATRICS 91(2):321-329
FREUND LS; REISS AL; ABRAMS MT
PSYCHIATRIC-DISORDERS ASSOCIATED WITH FRAGILE-X IN THE YOUNG FEMALE
54 76
73 32 85 478 1987 JOURNAL OF PEDIATRICS 110(6):821-831
CHUDLEY AE; HAGERMAN RJ
FRAGILE-X SYNDROME
53 80
74 0 0 25 1981 LANCET 1(8223):780-780
DAKER MG; CHIDIAC P; FEAR CN; BERRY AC
FRAGILE X IN A NORMAL-MALE - A CAUTIONARY TALE
52 84
75 1 10 348 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):581-587
GUSTAVSON KH; BLOMQUIST H; HOLMGREN G
PREVALENCE OF THE FRAGILE-X SYNDROME IN MENTALLY-RETARDED BOYS IN A SWEDISH COUNTY
52 74
76 5 10 871 1991 JOURNAL OF MEDICAL GENETICS 28(12):818-823
RICHARDS RI; HOLMAN K; KOZMAN H; KREMER E; LYNCH M; PRITCHARD M; YU S; MULLEY J; SUTHERLAND GR
FRAGILE-X SYNDROME - GENETIC LOCALIZATION BY LINKAGE MAPPING OF 2 MICROSATELLITE REPEATS FRAXAC1 AND FRAXAC2 WHICH IMMEDIATELY FLANK THE FRAGILE SITE
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77 12 22 908 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):35-46
REISS AL; FREUND L
BEHAVIORAL-PHENOTYPE OF FRAGILE-X SYNDROME - DSM-III-R AUTISTIC BEHAVIOR IN MALE-CHILDREN
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78 44 64 1754 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 84(3):250-261
Tassone F; Hagerman RJ; Ikle DN; Dyer PN; Lampe M; Willemsen R; Oostra BA; Taylor AK
FMRP expression as a potential prognostic indicator in fragile X syndrome
52 62
79 4 29 173 1984 AMERICAN JOURNAL OF MEDICAL GENETICS 17(1):175-194
PARTINGTON MW
THE FRAGILE-X SYNDROME .2. PRELIMINARY DATA ON GROWTH AND DEVELOPMENT IN MALES
51 65
80 1 2 317 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):11-67
TURNER G; OPITZ JM; BROWN WT; DAVIES KE; JACOBS PA; JENKINS EC; MIKKELSEN M; PARTINGTON MW; SUTHERLAND GR
CONFERENCE REPORT - 2ND INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND ON X-LINKED MENTAL-RETARDATION
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81 11 23 684 1990 AMERICAN JOURNAL ON MENTAL RETARDATION 94(4):431-441
SUDHALTER V; COHEN IL; SILVERMAN W; WOLFSCHEIN EG
CONVERSATIONAL ANALYSES OF MALES WITH FRAGILE-X, DOWN SYNDROME, AND AUTISM - COMPARISON OF THE EMERGENCE OF DEVIANT LANGUAGE
51 64
82 13 43 1346 1995 EMBO JOURNAL 14(11):2401-2408
SIOMI MC; SIOMI H; SAUER WH; SRINIVASAN S; NUSSBAUM RL; DREYFUSS G
FXR1, AN AUTOSOMAL HOMOLOG OF THE FRAGILE-X MENTAL-RETARDATION GENE
51 95
83 103 406 169 1984 AMERICAN JOURNAL OF MEDICAL GENETICS 17(1):5-94
OPITZ JM; SUTHERLAND GR
CONFERENCE REPORT - INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION
50 115
84 7 27 259 1985 CLINICAL GENETICS 27(2):113-117
BLOMQUIST HK; BOHMAN M; EDVINSSON SO; GILLBERG C; GUSTAVSON KH; HOLMGREN G; WAHLSTROM J
FREQUENCY OF THE FRAGILE X-SYNDROME IN INFANTILE-AUTISM - A SWEDISH MULTICENTER STUDY
50 84
85 12 32 559 1988 AMERICAN JOURNAL ON MENTAL RETARDATION 92(5):436-446
COHEN IL; FISCH GS; SUDHALTER V; WOLFSCHEIN EG; HANSON D; HAGERMAN R; JENKINS EC; BROWN WT
SOCIAL GAZE, SOCIAL AVOIDANCE, AND REPETITIVE BEHAVIOR IN FRAGILE X-MALES - A CONTROLLED-STUDY
50 71
86 1 9 1170 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):400-402
SCHWARTZ CE; DEAN J; HOWARDPEEBLES PN; BUGGE M; MIKKELSEN M; TOMMERUP N; HULL C; HAGERMAN R; HOLDEN JJA; STEVENSON RE
OBSTETRICAL AND GYNECOLOGICAL COMPLICATIONS IN FRAGILE-X CARRIERS - A MULTICENTER STUDY
50 84
87 2 8 74 1982 LANCET 1(8263):100-100
BROWN WT; FRIEDMAN E; JENKINS EC; BROOKS J; WISNIEWSKI K; RAGUTHU S; FRENCH JH
ASSOCIATION OF FRAGILE-X SYNDROME WITH AUTISM
49 77
88 13 23 1025 1993 AMERICAN JOURNAL OF HUMAN GENETICS 52(2):297-304
OUDET C; MORNET E; SERRE JL; THOMAS F; LENTESZENGERLING S; KRETZ C; DELUCHAT C; TEJADA I; BOUE J; BOUE A; MANDEL JL
LINKAGE DISEQUILIBRIUM BETWEEN THE FRAGILE-X MUTATION AND 2 CLOSELY LINKED CA REPEATS SUGGESTS THAT FRAGILE-X CHROMOSOMES ARE DERIVED FROM A SMALL NUMBER OF FOUNDER CHROMOSOMES
49 111
89 22 61 1251 1994 NEUROLOGY 44(7):1317-1324
REISS AL; LEE J; FREUND L
NEUROANATOMY OF FRAGILE-X SYNDROME - THE TEMPORAL-LOBE
49 83
90 22 40 1824 2000 AMERICAN JOURNAL OF HUMAN GENETICS 66(1):6-15
Tassone F; Hagerman RJ; Taylor AK; Gane LW; Godfrey TE; Hagerman PJ
Elevated levels of FMR1 mRNA in carrier males: A new mechanism of involvement in the fragile-X syndrome
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# LCR NCR Nodes / Date / Journal / Authors LCS GCS
91 2 40 20 1981 HUMAN GENETICS 59(4):281-289
MATTEI JF; MATTEI MG; AUMERAS C; AUGER M; GIRAUD F
X-LINKED MENTAL-RETARDATION WITH THE FRAGILE-X - A STUDY OF 15 FAMILIES
48 72
92 2 35 36 1982 AMERICAN JOURNAL OF DISEASES OF CHILDREN 136(5):392-398
CARPENTER NJ; LEICHTMAN LG; SAY B
FRAGILE X-LINKED MENTAL-RETARDATION - A SURVEY OF 65 PATIENTS WITH MENTAL-RETARDATION OF UNKNOWN ORIGIN
48 65
93 7 20 142 1983 JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 4(3):151-158
LEVITAS A; HAGERMAN RJ; BRADEN M; RIMLAND B; MCBOGG P; MATUS I
AUTISM AND THE FRAGILE-X SYNDROME
48 62
94 31 61 1158 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):317-327
ABRAMS MT; REISS AL; FREUND LS; BAUMGARDNER TL; CHASE GA; DENCKLA MB
MOLECULAR-NEUROBEHAVIORAL ASSOCIATIONS IN FEMALES WITH THE FRAGILE-X FULL MUTATION
48 65
95 16 57 1502 1996 MOLECULAR AND CELLULAR BIOLOGY 16(7):3825-3832
Siomi MC; Zhang Y; Siomi H; Dreyfuss G
Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them
48 98
96 17 85 2005 2001 CELL 107(4):489-499
Darnell JC; Jensen KB; Jin P; Brown V; Warren ST; Darnell RB
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
48 116
97 4 16 403 1986 NEUROPSYCHOLOGIA 24(3):405-409
MIEZEJESKI CM; JENKINS EC; HILL AL; WISNIEWSKI K; FRENCH JH; BROWN WT
A PROFILE OF COGNITIVE DEFICIT IN FEMALES FROM FRAGILE-X FAMILIES
47 60
98 5 42 422 1987 AMERICAN JOURNAL ON MENTAL RETARDATION 92(3):272-278
LACHIEWICZ AM; GULLION CM; SPIRIDIGLIOZZI GA; AYLSWORTH AS
DECLINING IQS OF YOUNG MALES WITH THE FRAGILE X-SYNDROME
47 63
99 7 17 1014 1992 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89(9):4215-4217
MORTON NE; MACPHERSON JN
POPULATION-GENETICS OF THE FRAGILE-X SYNDROME - MULTIALLELIC MODEL FOR THE FMR1 LOCUS
47 78
100 17 29 1221 1994 HUMAN MOLECULAR GENETICS 3(9):1543-1551
SNOW K; TESTER DJ; KRUCKEBERG KE; SCHAID DJ; THIBODEAU SN
SEQUENCE-ANALYSIS OF THE FRAGILE-X TRINUCLEOTIDE REPEAT - IMPLICATIONS FOR THE ORIGIN OF THE FRAGILE-X MUTATION
47 115

#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
1	11	40	839 1991 CELL 65(5):905-914 VERKERK AJMH; PIERETTI M; SUTCLIFFE JS; FU YH; KUHL DPA; PIZZUTI A; REINER O; RICHARDS S; VICTORIA MF; ZHANG FP; EUSSEN BE; VANOMMEN GJB; BLONDEN LAJ; RIGGINS GJ; CHASTAIN JL; KUNST CB; GALJAARD H; CASKEY CT; NELSON DL; OOSTRA BA; WARREN ST IDENTIFICATION OF A GENE (FMR-1) CONTAINING A CGG REPEAT COINCIDENT WITH A BREAKPOINT CLUSTER REGION EXHIBITING LENGTH VARIATION IN FRAGILE-X SYNDROME	501	1246
2	18	37	897 1991 SCIENCE 252(5009):1097-1102 OBERLE I; ROUSSEAU F; HEITZ D; KRETZ C; DEVYS D; HANAUER A; BOUE J; BERTHEAS MF; MANDEL JL INSTABILITY OF A 550 BASE PAIR DNA SEGMENT AND ABNORMAL METHYLATION IN FRAGILE X-SYNDROME	394	835
3	12	23	841 1991 CELL 67(6):1047-1058 FU YH; KUHL DPA; PIZZUTI A; PIERETTI M; SUTCLIFFE JS; RICHARDS S; VERKERK AJMH; HOLDEN JJA; FENWICK RG; WARREN ST; OOSTRA BA; NELSON DL; CASKEY CT VARIATION OF THE CGG REPEAT AT THE FRAGILE-X SITE RESULTS IN GENETIC INSTABILITY - RESOLUTION OF THE SHERMAN PARADOX	368	933
4	10	15	840 1991 CELL 66(4):817-822 PIERETTI M; ZHANG FP; FU YH; WARREN ST; OOSTRA BA; CASKEY CT; NELSON DL ABSENCE OF EXPRESSION OF THE FMR-1 GENE IN FRAGILE-X SYNDROME	291	583
5	3	9	898 1991 SCIENCE 252(5009):1179-1181 YU S; PRITCHARD M; KREMER E; LYNCH M; NANCARROW J; BAKER E; HOLMAN K; MULLEY JC; WARREN ST; SCHLESSINGER D; SUTHERLAND GR; RICHARDS RI FRAGILE-X GENOTYPE CHARACTERIZED BY AN UNSTABLE REGION OF DNA	274	537
6	15	28	885 1991 NEW ENGLAND JOURNAL OF MEDICINE 325(24):1673-1681 ROUSSEAU F; HEITZ D; BIANCALANA V; BLUMENFELD S; KRETZ C; BOUE J; TOMMERUP N; VANDERHAGEN C; DELOZIERBLANCHET C; CROQUETTE MF; GILGENKRANTZ S; JALBERT P; VOELCKEL MA; OBERLE I; MANDEL JL DIRECT DIAGNOSIS BY DNA ANALYSIS OF THE FRAGILE X-SYNDROME OF MENTAL-RETARDATION	268	438
7	11	40	285 1985 HUMAN GENETICS 69(4):289-299 SHERMAN SL; JACOBS PA; MORTON NE; FROSTERISKENIUS U; HOWARDPEEBLES PN; NIELSEN KB; PARTINGTON MW; SUTHERLAND GR; TURNER G; WATSON M FURTHER SEGREGATION ANALYSIS OF THE FRAGILE-X SYNDROME WITH SPECIAL REFERENCE TO TRANSMITTING MALES	226	348
8	5	13	899 1991 SCIENCE 252(5013):1711-1714 KREMER EJ; PRITCHARD M; LYNCH M; YU S; HOLMAN K; BAKER E; WARREN ST; SCHLESSINGER D; SUTHERLAND GR; RICHARDS RI MAPPING OF DNA INSTABILITY AT THE FRAGILE-X TO A TRINUCLEOTIDE REPEAT SEQUENCE P(CCG)N	200	575
9	19	36	1138 1993 NATURE GENETICS 4(4):335-340 DEVYS D; LUTZ Y; ROUYER N; BELLOCQ JP; MANDEL JL THE FMR-1 PROTEIN IS CYTOPLASMIC, MOST ABUNDANT IN NEURONS AND APPEARS NORMAL IN CARRIERS OF A FRAGILE X PREMUTATION	169	277
10	11	12	1412 1996 AMERICAN JOURNAL OF MEDICAL GENETICS 64(1):196-197 Turner G; Webb T; Wake S; Robinson H Prevalence of fragile X syndrome	137	223
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
11	16	27	1133 1993 NATURE GENETICS 3(1):31-35 DEBOULLE K; VERKERK AJMH; REYNIERS E; VITS L; HENDRICKX J; VANROY B; VANDENBOS F; DEGRAAFF E; OOSTRA BA; WILLEMS PJ A POINT MUTATION IN THE FMR-1 GENE ASSOCIATED WITH FRAGILE-X MENTAL-RETARDATION	131	262
12	30	38	1151 1994 AMERICAN JOURNAL OF HUMAN GENETICS 55(2):225-237 ROUSSEAU F; HEITZ D; TARLETON J; MACPHERSON J; MALMGREN H; DAHL N; BARNICOAT A; MATHEW C; MORNET E; TEJADA I; MADDALENA A; SPIEGEL R; SCHINZEL A; MARCOS JAG; SCHORDERET DF; SCHAAP T; MACCIONI L; RUSSO S; JACOBS PA; SCHWARTZ C; MANDEL JL A MULTICENTER STUDY ON GENOTYPE-PHENOTYPE CORRELATIONS IN THE FRAGILE-X-SYNDROME, USING DIRECT DIAGNOSIS WITH PROBE STB-12.3 - THE FIRST 2,253 CASES	119	165
13	9	34	838 1991 CELL 64(4):861-866 BELL MV; HIRST MC; NAKAHORI Y; MACKINNON RN; ROCHE A; FLINT TJ; JACOBS PA; TOMMERUP N; TRANEBJAERG L; FROSTERISKENIUS U; KERR B; TURNER G; LINDENBAUM RH; WINTER R; PEMBREY M; THIBODEAU S; DAVIES KE PHYSICAL MAPPING ACROSS THE FRAGILE-X - HYPERMETHYLATION AND CLINICAL EXPRESSION OF THE FRAGILE-X SYNDROME	118	222
14	15	56	1076 1993 CELL 74(2):291-298 SIOMI H; SIOMI MC; NUSSBAUM RL; DREYFUSS G THE PROTEIN PRODUCT OF THE FRAGILE-X GENE, FMR1, HAS CHARACTERISTICS OF AN RNA-BINDING PROTEIN	117	315
15	10	29	1626 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(10):5401-5404 Comery TA; Harris JB; Willems PJ; Oostra BA; Irwin SA; Weiler IJ; Greenough WT Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits	111	201
16	11	14	882 1991 NATURE 349(6310):624-626 VINCENT A; HEITZ D; PETIT C; KRETZ C; OBERLE I; MANDEL JL ABNORMAL PATTERN DETECTED IN FRAGILE-X PATIENTS BY PULSED-FIELD GEL-ELECTROPHORESIS	105	164
17	20	55	1105 1993 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 270(13):1569-1575 BROWN WT; HOUCK GE; JEZIOROWSKA A; LEVINSON FN; DING XH; DOBKIN C; ZHONG N; HENDERSON J; BROOKS SS; JENKINS EC RAPID FRAGILE-X CARRIER SCREENING AND PRENATAL-DIAGNOSIS USING A NONRADIOACTIVE PCR TEST	103	154
18	8	17	1132 1993 NATURE 363(6431):722-724 VERHEIJ C; BAKKER CE; DEGRAAFF E; KEULEMANS J; WILLEMSEN R; VERKERK AJMH; GALJAARD H; REUSER AJJ; HOOGEVEEN AT; OOSTRA BA CHARACTERIZATION AND LOCALIZATION OF THE FMR-1 GENE-PRODUCT ASSOCIATED WITH FRAGILE-X SYNDROME	103	182
19	1	6	404 1986 NEW ENGLAND JOURNAL OF MEDICINE 315(10):607-609 TURNER G; ROBINSON H; LAING S; PURVISSMITH S PREVENTIVE SCREENING FOR THE FRAGILE-X SYNDROME	95	123
20	15	30	901 1992 AMERICAN JOURNAL OF HUMAN GENETICS 50(5):968-980 YU S; MULLEY J; LOESCH D; TURNER G; DONNELLY A; GEDEON A; HILLEN D; KREMER E; LYNCH M; PRITCHARD M; SUTHERLAND GR; RICHARDS RI FRAGILE-X SYNDROME - UNIQUE GENETICS OF THE HERITABLE UNSTABLE ELEMENT	93	174
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
21	15	42	447 1987 GENETICS 117(3):587-599 LAIRD CD PROPOSED MECHANISM OF INHERITANCE AND EXPRESSION OF THE HUMAN FRAGILE-X SYNDROME OF MENTAL-RETARDATION	92	167
22	20	33	1134 1993 NATURE GENETICS 3(1):36-43 HINDS HL; ASHLEY CT; SUTCLIFFE JS; NELSON DL; WARREN ST; HOUSMAN DE; SCHALLING M TISSUE SPECIFIC EXPRESSION OF FMR-1 PROVIDES EVIDENCE FOR A FUNCTIONAL-ROLE IN FRAGILE-X SYNDROME	91	154
23	9	33	895 1991 SCIENCE 251(4998):1236-1239 HEITZ D; ROUSSEAU F; DEVYS D; SACCONE S; ABDERRAHIM H; LEPASLIER D; COHEN D; VINCENT A; TONIOLO D; DELLAVALLE G; JOHNSON S; SCHLESSINGER D; OBERLE I; MANDEL JL ISOLATION OF SEQUENCES THAT SPAN THE FRAGILE-X AND IDENTIFICATION OF A FRAGILE-X RELATED CPG ISLAND	86	139
24	16	58	1625 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(10):5395-5400 Weiler IJ; Irwin SA; Klintsova AY; Spencer CM; Brazelton AD; Miyashiro K; Comery TA; Patel B; Eberwine J; Greenough WT Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation	86	174
25	22	34	1058 1993 AMERICAN JOURNAL OF HUMAN GENETICS 53(6):1217-1228 SNOW K; DOUD LK; HAGERMAN R; PERGOLIZZI RG; ERSTER SH; THIBODEAU SN ANALYSIS OF A CGG SEQUENCE AT THE FMR-I LOCUS IN FRAGILE-X FAMILIES AND IN THE GENERAL-POPULATION	84	136
26	12	32	246 1985 AMERICAN JOURNAL OF MEDICAL GENETICS 21(4):709-717 PEMBREY ME; WINTER RM; DAVIES KE A PRE-MUTATION THAT GENERATES A DEFECT AT CROSSING OVER EXPLAINS THE INHERITANCE OF FRAGILE X MENTAL RETARDATION	82	116
27	10	23	1009 1992 NATURE GENETICS 1(5):341-344 GEDEON AK; BAKER E; ROBINSON H; PARTINGTON MW; GROSS B; MANCA A; KORN B; POUSTKA A; YU S; SUTHERLAND GR; MULLEY JC FRAGILE-X SYNDROME WITHOUT CCG AMPLIFICATION HAS AN FMR1 DELETION	82	137
28	28	44	1137 1993 NATURE GENETICS 4(2):143-146 REYNIERS E; VITS L; DEBOULLE K; VANROY B; VANVELZEN D; DEGRAAFF E; VERKERK AJMH; JORENS HZJ; DARBY JK; OOSTRA B; WILLEMS PJ THE FULL MUTATION IN THE FMR-1 GENE OF MALE FRAGILE-X PATIENTS IS ABSENT IN THEIR SPERM	82	167
29	8	33	153 1983 NATURE 306(5944):701-704 CAMERINO G; MATTEI MG; MATTEI JF; JAYE M; MANDEL JL CLOSE LINKAGE OF FRAGILE X MENTAL-RETARDATION SYNDROME TO HEMOPHILIA-B AND TRANSMISSION THROUGH A NORMAL-MALE	78	171
30	22	52	1208 1994 CELL 78(1):23-33 BAKKER CE; VERHEIJ C; WILLEMSEN R; VANDERHELM R; OERLEMANS F; VERMEY M; BYGRAVE A; HOOGEVEEN AT; OOSTRA BA; REYNIERS E; DEBOULLE K; DHOOGE R; CRAS P; VANVELZEN D; NAGELS G; MARTIN JJ; DEDEYN PP; DARBY JK; WILLEMS PJ FMR1 KNOCKOUT MICE - A MODEL TO STUDY FRAGILE-X MENTAL-RETARDATION	78	147
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
31	33	42	1291 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(5):1006-1018 ROUSSEAU F; ROUILLARD P; MOREL ML; KHANDJIAN EW; MORGAN K PREVALENCE OF CARRIERS OF PREMUTATION-SIZE ALLELES OF THE FMRI GENE AND IMPLICATIONS FOR THE POPULATION-GENETICS OF THE FRAGILE-X SYNDROME	78	105
32	5	23	69 1982 JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS 12(3):303-308 BROWN WT; JENKINS EC; FRIEDMAN E; BROOKS J; WISNIEWSKI K; RAGUTHU S; FRENCH J AUTISM IS ASSOCIATED WITH THE FRAGILE-X SYNDROME	77	121
33	5	26	319 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):157-169 FRYNS JP THE FEMALE AND THE FRAGILE-X - A STUDY OF 144 OBLIGATE FEMALE CARRIERS	76	101
34	10	39	831 1991 AMERICAN JOURNAL OF MEDICAL GENETICS 41(3):289-294 HINTON VJ; BROWN WT; WISNIEWSKI K; RUDELLI RD ANALYSIS OF NEOCORTEX IN 3 MALES WITH THE FRAGILE-X SYNDROME	76	117
35	30	48	1226 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):507-514 TAYLOR AK; SAFANDA JF; FALL MZ; QUINCE C; LANG KA; HULL CE; CARPENTER I; STALEY LW; HAGERMAN RJ MOLECULAR PREDICTORS OF COGNITIVE INVOLVEMENT IN FEMALE CARRIERS OF FRAGILE-X SYNDROME	76	89
36	13	42	334 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):359-374 HAGERMAN RJ; JACKSON AW; LEVITAS A; RIMLAND B; BRADEN M AN ANALYSIS OF AUTISM IN 50 MALES WITH THE FRAGILE-X SYNDROME	74	104
37	17	53	1485 1996 HUMAN MOLECULAR GENETICS 5(8):1083-1091 Eberhart DE; Malter HE; Feng Y; Warren ST The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals	74	120
38	18	23	903 1992 AMERICAN JOURNAL OF HUMAN GENETICS 51(2):299-306 WOHRLE D; KOTZOT D; HIRST MC; MANCA A; KORN B; SCHMIDT A; BARBI G; ROTT HD; POUSTKA A; DAVIES KE; STEINBACH P A MICRODELETION OF LESS THAN 250 KB, INCLUDING THE PROXIMAL PART OF THE FMR-I GENE AND THE FRAGILE-X SITE, IN A MALE WITH THE CLINICAL PHENOTYPE OF FRAGILE-X SYNDROME	73	121
39	8	9	1377 1995 LANCET 345(8958):1147-1148 WILLEMSEN R; MOHKAMSING S; DEVRIES B; DEVYS D; VANDENOUWELAND A; MANDEL JL; GALJAARD H; OOSTRA B RAPID ANTIBODY-TEST FOR FRAGILE-X SYNDROME	73	94
40	23	34	994 1992 JOURNAL OF MEDICAL GENETICS 29(11):794-801 HEITZ D; DEVYS D; IMBERT G; KRETZ C; MANDEL JL INHERITANCE OF THE FRAGILE-X SYNDROME - SIZE OF THE FRAGILE-X PREMUTATION IS A MAJOR DETERMINANT OF THE TRANSITION TO FULL MUTATION	72	108
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
41	7	52	235 1985 ACTA NEUROPATHOLOGICA 67(3-4):289-295 RUDELLI RD; BROWN WT; WISNIEWSKI K; JENKINS EC; LAUREKAMIONOWSKA M; CONNELL F; WISNIEWSKI HM ADULT FRAGILE X-SYNDROME - CLINICO-NEUROPATHOLOGIC FINDINGS	71	110
42	23	59	1613 1997 JOURNAL OF NEUROSCIENCE 17(5):1539-1547 Feng Y; Gutekunst CA; Eberhart DE; Yi H; Warren ST; Hersch SM Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritic ribosomes	71	131
43	18	51	332 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):341-352 BROWN WT; JENKINS EC; COHEN IL; FISCH GS; WOLFSCHEIN EG; GROSS A; WATERHOUSE L; FEIN D; MASONBROTHERS A; RITVO E; RUTTENBERG BA; BENTLEY W; CASTELLS S FRAGILE-X AND AUTISM - A MULTICENTER SURVEY	70	108
44	23	47	1026 1993 AMERICAN JOURNAL OF HUMAN GENETICS 52(5):884-894 REISS AL; FREUND L; ABRAMS MT; BOEHM C; KAZAZIAN H NEUROBEHAVIORAL EFFECTS OF THE FRAGILE-X PREMUTATION IN ADULT WOMEN - A CONTROLLED-STUDY	70	95
45	20	53	1207 1994 CELL 77(6):853-861 KUNST CB; WARREN ST CRYPTIC AND POLAR VARIATION OF THE FRAGILE-X REPEAT COULD RESULT IN PREDISPOSING NORMAL ALLELES	70	239
46	8	20	1008 1992 NATURE GENETICS 1(4):257-260 RICHARDS RI; HOLMAN K; FRIEND K; KREMER E; HILLEN D; STAPLES A; BROWN WT; GOONEWARDENA P; TARLETON J; SCHWARTZ C; SUTHERLAND GR EVIDENCE OF FOUNDER CHROMOSOMES IN FRAGILE-X SYNDROME	69	158
47	4	11	393 1986 JOURNAL OF MEDICAL GENETICS 23(5):396-399 WEBB TP; BUNDEY S; THAKE A; TODD J THE FREQUENCY OF THE FRAGILE X-CHROMOSOME AMONG SCHOOLCHILDREN IN COVENTRY	68	105
48	14	37	1110 1993 JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 14(5):328-335 MAZZOCCO MMM; PENNINGTON BF; HAGERMAN RJ THE NEUROCOGNITIVE PHENOTYPE OF FEMALE CARRIERS OF FRAGILE-X - ADDITIONAL EVIDENCE FOR SPECIFICITY	68	87
49	38	61	1155 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):298-308 HAGERMAN RJ; HULL CE; SAFANDA JF; CARPENTER I; STALEY LW; OCONNOR RA; SEYDEL C; MAZZOCCO MMM; SNOW K; THIBODEAU SN; KUHL D; NELSON DL; CASKEY CT; TAYLOR AK HIGH FUNCTIONING FRAGILE-X MALES - DEMONSTRATION OF AN UNMETHYLATED FULLY EXPANDED FMR-1 MUTATION ASSOCIATED WITH PROTEIN EXPRESSION	67	95
50	24	47	1617 1997 MOLECULAR CELL 1(1):109-118 Feng Y; Absher D; Eberhart DE; Brown V; Malter HE; Warren ST FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association	65	114
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
51	15	39	1206 1994 CELL 77(1):33-39 SIOMI H; CHOI MY; SIOMI MC; NUSSBAUM RL; DREYFUSS G ESSENTIAL ROLE FOR KH DOMAINS IN RNA-BINDING - IMPAIRED RNA-BINDING BY A MUTATION IN THE KH DOMAIN OF FMR1 THAT CAUSES FRAGILE-X SYNDROME	64	254
52	38	118	362 1986 ANNUAL REVIEW OF GENETICS 20:109-145 NUSSBAUM RL; LEDBETTER DH FRAGILE-X SYNDROME - A UNIQUE MUTATION IN MAN	63	112
53	23	41	1056 1993 AMERICAN JOURNAL OF HUMAN GENETICS 53(4):800-809 MCCONKIEROSELL A; LACHIEWICZ AM; SPIRIDIGLIOZZI GA; TARLETON J; SCHOENWALD S; PHELAN MC; GOONEWARDENA P; DING XH; BROWN WT EVIDENCE THAT METHYLATION OF THE FMR-I LOCUS IS RESPONSIBLE FOR VARIABLE PHENOTYPIC-EXPRESSION OF THE FRAGILE-X SYNDROME	63	99
54	16	36	1347 1995 EMBO JOURNAL 14(21):5358-5366 ZHANG Y; OCONNOR JP; SIOMI MC; SRINIVASAN S; DUTRA A; NUSSBAUM RL; DREYFUSS G THE FRAGILE-X MENTAL-RETARDATION SYNDROME PROTEIN INTERACTS WITH NOVEL HOMOLOGS FXR1 AND FXR2	63	111
55	11	20	873 1991 JOURNAL OF MEDICAL GENETICS 28(12):830-836 ROUSSEAU F; HEITZ D; OBERLE I; MANDEL JL SELECTION IN BLOOD-CELLS FROM FEMALE CARRIERS OF THE FRAGILE-X SYNDROME - INVERSE CORRELATION BETWEEN AGE AND PROPORTION OF ACTIVE X-CHROMOSOMES CARRYING THE FULL MUTATION	62	84
56	6	11	886 1991 NEW ENGLAND JOURNAL OF MEDICINE 325(24):1720-1722 SUTHERLAND GR; GEDEON A; KORNMAN L; DONNELLY A; BYARD RW; MULLEY JC; KREMER E; LYNCH M; PRITCHARD M; YU S; RICHARDS RI PRENATAL-DIAGNOSIS OF FRAGILE X-SYNDROME BY DIRECT DETECTION OF THE UNSTABLE DNA-SEQUENCE	61	86
57	10	20	890 1991 NUCLEIC ACIDS RESEARCH 19(16):4355-4359 NAKAHORI Y; KNIGHT SJL; HOLLAND J; SCHWARTZ C; ROCHE A; TARLETON J; WONG S; FLINT TJ; FROSTERISKENIUS U; BENTLEY D; DAVIES KE; HIRST MC MOLECULAR HETEROGENEITY OF THE FRAGILE-X SYNDROME	61	91
58	41	81	1227 1994 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 271(7):536-542 WARREN ST; NELSON DL ADVANCES IN MOLECULAR ANALYSIS OF FRAGILE-X SYNDROME	59	125
59	10	15	933 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):208-216 DEVYS D; BIANCALANA V; ROUSSEAU F; BOUE J; MANDEL JL; OBERLE I ANALYSIS OF FULL FRAGILE-X MUTATIONS IN FETAL TISSUES AND MONOZYGOTIC TWINS INDICATE THAT ABNORMAL METHYLATION AND SOMATIC HETEROGENEITY ARE ESTABLISHED EARLY IN DEVELOPMENT	58	89
60	19	23	1136 1993 NATURE GENETICS 4(2):140-142 WOHRLE D; HENNIG I; VOGEL W; STEINBACH P MITOTIC STABILITY OF FRAGILE-X MUTATIONS IN DIFFERENTIATED CELLS INDICATES EARLY POSTCONCEPTIONAL TRINUCLEOTIDE REPEAT EXPANSION	58	120
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
61	10	31	1503 1996 NATURE GENETICS 12(1):91-93 Khandjian EW; Corbin F; Woerly S; Rousseau F The fragile X mental retardation protein is associated with ribosomes	58	93
62	21	31	1011 1992 PEDIATRICS 89(3):395-400 HAGERMAN RJ; JACKSON C; AMIRI K; SILVERMAN AC; OCONNOR R; SOBESKY W GIRLS WITH FRAGILE-X SYNDROME - PHYSICAL AND NEUROCOGNITIVE STATUS AND OUTCOME	57	79
63	1	4	28 1981 LANCET 2(8258):1292-1292 JENKINS EC; BROWN WT; DUNCAN CJ; BROOKS J; BENYISHAY M; GIORDANO FM; NITOWSKY HM FEASIBILITY OF FRAGILE X-CHROMOSOME PRENATAL-DIAGNOSIS DEMONSTRATED	56	77
64	8	32	105 1983 AMERICAN JOURNAL OF MEDICAL GENETICS 14(4):699-712 CHUDLEY AE; KNOLL J; GERRARD JW; SHEPEL L; MCGAHEY E; ANDERSON J FRAGILE (X) X-LINKED MENTAL-RETARDATION .1. RELATIONSHIP BETWEEN AGE AND INTELLIGENCE AND THE FREQUENCY OF EXPRESSION OF FRAGILE (X)(Q28)	56	80
65	0	3	191 1984 CLINICAL GENETICS 25(2):131-134 FRYNS JP; JACOBS J; KLECZKOWSKA A; VANDENBERGHE H THE PSYCHOLOGICAL PROFILE OF THE FRAGILE X-SYNDROME	56	75
66	7	32	560 1988 ARCHIVES OF GENERAL PSYCHIATRY 45(1):25-30 REISS AL; HAGERMAN RJ; VINOGRADOV S; ABRAMS M; KING RJ PSYCHIATRIC DISABILITY IN FEMALE CARRIERS OF THE FRAGILE X-CHROMOSOME	56	91
67	13	27	519 1988 AMERICAN JOURNAL OF MEDICAL GENETICS 30(1-2):191-200 KEMPER MB; HAGERMAN RJ; ALTSHULSTARK D COGNITIVE PROFILES OF BOYS WITH THE FRAGILE-X SYNDROME	55	73
68	12	38	1595 1997 HUMAN MOLECULAR GENETICS 6(9):1465-1472 Corbin F; Bouillon M; Fortin A; Morin S; Rousseau F; Khandjian EW The fragile X mental retardation protein is associated with poly(A)(+) mRNA in actively translating polyribosomes	55	85
69	19	31	2023 2001 HUMAN MOLECULAR GENETICS 10(4):329-338 Laggerbauer B; Ostareck D; Keidel EM; Ostareck-Lederer A; Fischer U Evidence that fragile X mental retardation protein is a negative regulator of translation	55	80
70	9	24	238 1985 AMERICAN JOURNAL OF DISEASES OF CHILDREN 139(7):674-678 HAGERMAN R; KEMPER M; HUDSON M LEARNING-DISABILITIES AND ATTENTIONAL PROBLEMS IN BOYS WITH THE FRAGILE X-SYNDROME	54	71
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
71	4	31	833 1991 ANNALS OF NEUROLOGY 29(1):26-32 REISS AL; AYLWARD E; FREUND LS; JOSHI PK; BRYAN RN NEUROANATOMY OF FRAGILE-X-SYNDROME - THE POSTERIOR-FOSSA	54	110
72	20	37	1143 1993 PEDIATRICS 91(2):321-329 FREUND LS; REISS AL; ABRAMS MT PSYCHIATRIC-DISORDERS ASSOCIATED WITH FRAGILE-X IN THE YOUNG FEMALE	54	76
73	32	85	478 1987 JOURNAL OF PEDIATRICS 110(6):821-831 CHUDLEY AE; HAGERMAN RJ FRAGILE-X SYNDROME	53	80
74	0	0	25 1981 LANCET 1(8223):780-780 DAKER MG; CHIDIAC P; FEAR CN; BERRY AC FRAGILE X IN A NORMAL-MALE - A CAUTIONARY TALE	52	84
75	1	10	348 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):581-587 GUSTAVSON KH; BLOMQUIST H; HOLMGREN G PREVALENCE OF THE FRAGILE-X SYNDROME IN MENTALLY-RETARDED BOYS IN A SWEDISH COUNTY	52	74
76	5	10	871 1991 JOURNAL OF MEDICAL GENETICS 28(12):818-823 RICHARDS RI; HOLMAN K; KOZMAN H; KREMER E; LYNCH M; PRITCHARD M; YU S; MULLEY J; SUTHERLAND GR FRAGILE-X SYNDROME - GENETIC LOCALIZATION BY LINKAGE MAPPING OF 2 MICROSATELLITE REPEATS FRAXAC1 AND FRAXAC2 WHICH IMMEDIATELY FLANK THE FRAGILE SITE	52	100
77	12	22	908 1992 AMERICAN JOURNAL OF MEDICAL GENETICS 43(1-2):35-46 REISS AL; FREUND L BEHAVIORAL-PHENOTYPE OF FRAGILE-X SYNDROME - DSM-III-R AUTISTIC BEHAVIOR IN MALE-CHILDREN	52	71
78	44	64	1754 1999 AMERICAN JOURNAL OF MEDICAL GENETICS 84(3):250-261 Tassone F; Hagerman RJ; Ikle DN; Dyer PN; Lampe M; Willemsen R; Oostra BA; Taylor AK FMRP expression as a potential prognostic indicator in fragile X syndrome	52	62
79	4	29	173 1984 AMERICAN JOURNAL OF MEDICAL GENETICS 17(1):175-194 PARTINGTON MW THE FRAGILE-X SYNDROME .2. PRELIMINARY DATA ON GROWTH AND DEVELOPMENT IN MALES	51	65
80	1	2	317 1986 AMERICAN JOURNAL OF MEDICAL GENETICS 23(1-2):11-67 TURNER G; OPITZ JM; BROWN WT; DAVIES KE; JACOBS PA; JENKINS EC; MIKKELSEN M; PARTINGTON MW; SUTHERLAND GR CONFERENCE REPORT - 2ND INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND ON X-LINKED MENTAL-RETARDATION	51	71
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
81	11	23	684 1990 AMERICAN JOURNAL ON MENTAL RETARDATION 94(4):431-441 SUDHALTER V; COHEN IL; SILVERMAN W; WOLFSCHEIN EG CONVERSATIONAL ANALYSES OF MALES WITH FRAGILE-X, DOWN SYNDROME, AND AUTISM - COMPARISON OF THE EMERGENCE OF DEVIANT LANGUAGE	51	64
82	13	43	1346 1995 EMBO JOURNAL 14(11):2401-2408 SIOMI MC; SIOMI H; SAUER WH; SRINIVASAN S; NUSSBAUM RL; DREYFUSS G FXR1, AN AUTOSOMAL HOMOLOG OF THE FRAGILE-X MENTAL-RETARDATION GENE	51	95
83	103	406	169 1984 AMERICAN JOURNAL OF MEDICAL GENETICS 17(1):5-94 OPITZ JM; SUTHERLAND GR CONFERENCE REPORT - INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION	50	115
84	7	27	259 1985 CLINICAL GENETICS 27(2):113-117 BLOMQUIST HK; BOHMAN M; EDVINSSON SO; GILLBERG C; GUSTAVSON KH; HOLMGREN G; WAHLSTROM J FREQUENCY OF THE FRAGILE X-SYNDROME IN INFANTILE-AUTISM - A SWEDISH MULTICENTER STUDY	50	84
85	12	32	559 1988 AMERICAN JOURNAL ON MENTAL RETARDATION 92(5):436-446 COHEN IL; FISCH GS; SUDHALTER V; WOLFSCHEIN EG; HANSON D; HAGERMAN R; JENKINS EC; BROWN WT SOCIAL GAZE, SOCIAL AVOIDANCE, AND REPETITIVE BEHAVIOR IN FRAGILE X-MALES - A CONTROLLED-STUDY	50	71
86	1	9	1170 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):400-402 SCHWARTZ CE; DEAN J; HOWARDPEEBLES PN; BUGGE M; MIKKELSEN M; TOMMERUP N; HULL C; HAGERMAN R; HOLDEN JJA; STEVENSON RE OBSTETRICAL AND GYNECOLOGICAL COMPLICATIONS IN FRAGILE-X CARRIERS - A MULTICENTER STUDY	50	84
87	2	8	74 1982 LANCET 1(8263):100-100 BROWN WT; FRIEDMAN E; JENKINS EC; BROOKS J; WISNIEWSKI K; RAGUTHU S; FRENCH JH ASSOCIATION OF FRAGILE-X SYNDROME WITH AUTISM	49	77
88	13	23	1025 1993 AMERICAN JOURNAL OF HUMAN GENETICS 52(2):297-304 OUDET C; MORNET E; SERRE JL; THOMAS F; LENTESZENGERLING S; KRETZ C; DELUCHAT C; TEJADA I; BOUE J; BOUE A; MANDEL JL LINKAGE DISEQUILIBRIUM BETWEEN THE FRAGILE-X MUTATION AND 2 CLOSELY LINKED CA REPEATS SUGGESTS THAT FRAGILE-X CHROMOSOMES ARE DERIVED FROM A SMALL NUMBER OF FOUNDER CHROMOSOMES	49	111
89	22	61	1251 1994 NEUROLOGY 44(7):1317-1324 REISS AL; LEE J; FREUND L NEUROANATOMY OF FRAGILE-X SYNDROME - THE TEMPORAL-LOBE	49	83
90	22	40	1824 2000 AMERICAN JOURNAL OF HUMAN GENETICS 66(1):6-15 Tassone F; Hagerman RJ; Taylor AK; Gane LW; Godfrey TE; Hagerman PJ Elevated levels of FMR1 mRNA in carrier males: A new mechanism of involvement in the fragile-X syndrome	49	82
#	LCR	NCR	Nodes / Date / Journal / Authors	LCS	GCS
91	2	40	20 1981 HUMAN GENETICS 59(4):281-289 MATTEI JF; MATTEI MG; AUMERAS C; AUGER M; GIRAUD F X-LINKED MENTAL-RETARDATION WITH THE FRAGILE-X - A STUDY OF 15 FAMILIES	48	72
92	2	35	36 1982 AMERICAN JOURNAL OF DISEASES OF CHILDREN 136(5):392-398 CARPENTER NJ; LEICHTMAN LG; SAY B FRAGILE X-LINKED MENTAL-RETARDATION - A SURVEY OF 65 PATIENTS WITH MENTAL-RETARDATION OF UNKNOWN ORIGIN	48	65
93	7	20	142 1983 JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS 4(3):151-158 LEVITAS A; HAGERMAN RJ; BRADEN M; RIMLAND B; MCBOGG P; MATUS I AUTISM AND THE FRAGILE-X SYNDROME	48	62
94	31	61	1158 1994 AMERICAN JOURNAL OF MEDICAL GENETICS 51(4):317-327 ABRAMS MT; REISS AL; FREUND LS; BAUMGARDNER TL; CHASE GA; DENCKLA MB MOLECULAR-NEUROBEHAVIORAL ASSOCIATIONS IN FEMALES WITH THE FRAGILE-X FULL MUTATION	48	65
95	16	57	1502 1996 MOLECULAR AND CELLULAR BIOLOGY 16(7):3825-3832 Siomi MC; Zhang Y; Siomi H; Dreyfuss G Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them	48	98
96	17	85	2005 2001 CELL 107(4):489-499 Darnell JC; Jensen KB; Jin P; Brown V; Warren ST; Darnell RB Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function	48	116
97	4	16	403 1986 NEUROPSYCHOLOGIA 24(3):405-409 MIEZEJESKI CM; JENKINS EC; HILL AL; WISNIEWSKI K; FRENCH JH; BROWN WT A PROFILE OF COGNITIVE DEFICIT IN FEMALES FROM FRAGILE-X FAMILIES	47	60
98	5	42	422 1987 AMERICAN JOURNAL ON MENTAL RETARDATION 92(3):272-278 LACHIEWICZ AM; GULLION CM; SPIRIDIGLIOZZI GA; AYLSWORTH AS DECLINING IQS OF YOUNG MALES WITH THE FRAGILE X-SYNDROME	47	63
99	7	17	1014 1992 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89(9):4215-4217 MORTON NE; MACPHERSON JN POPULATION-GENETICS OF THE FRAGILE-X SYNDROME - MULTIALLELIC MODEL FOR THE FMR1 LOCUS	47	78
100	17	29	1221 1994 HUMAN MOLECULAR GENETICS 3(9):1543-1551 SNOW K; TESTER DJ; KRUCKEBERG KE; SCHAID DJ; THIBODEAU SN SEQUENCE-ANALYSIS OF THE FRAGILE-X TRINUCLEOTIDE REPEAT - IMPLICATIONS FOR THE ORIGIN OF THE FRAGILE-X MUTATION	47	115

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