#	Cited nodes	Nodes / Authors	GCS	LCS
101	4	7206 1990 LANCET 336(8714):529-532 HEIM M; MEYER UA GENOTYPING OF POOR METABOLIZERS OF DEBRISOQUINE BY ALLELE- SPECIFIC PCR AMPLIFICATION	384	46
102	5	1884 1972 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 4(2):65-& SCHOENE B; OLDERSHA.HF; FLEISCHM.RA; REMMER H DETERMINATION OF DRUG-METABOLIZING ENZYMES IN NEEDLE BIOPSIES OF HUMAN LIVER	383	38
103	86	7260 1990 PHARMACOLOGY & THERAPEUTICS 45(1):1-38 GONZALEZ FJ MOLECULAR-GENETICS OF THE P-450 SUPERFAMILY	382	183
104	3	148 1962 ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY 24():291-358 DEDUVE C; WATTIAUX R; BAUDHUIN P DISTRIBUTION OF ENZYMES BETWEEN SUBCELLULAR FRACTIONS IN ANIMAL TISSUES	380	8
105	30	2748 1975 BIOCHIMICA ET BIOPHYSICA ACTA 415(4):411-472 DEPIERRE JW; DALLNER G STRUCTURAL ASPECTS OF MEMBRANE OF ENDOPLASMIC-RETICULUM	379	55
106	43	10106 1996 CHEMICAL REVIEWS 96(7):2841-2887 Sono M; Roach MP; Coulter ED; Dawson JH Heme-containing oxygenases	378	19
107	6	466 1966 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 117(3):660-& OMURA T; SANDERS E; ESTABROOK RW; COOPER DY; ROSENTHA.O ISOLATION FROM ADRENAL CORTEX OF A NONHEME IRON PROTEIN AND A FLAVOPROTEIN FUNCT+ONAL AS A REDUCED TRIPHOSPHORYRIDINE NUCLEOTIDE-CYTOCHROME P-450 REDUCTASE	377	377
108	32	7625 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(16):10019-10022 GUENGERICH FP REACTIONS AND SIGNIFICANCE OF CYTOCHROME-P-450 ENZYMES	377	176
109	17	8154 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(1):83-90 GOTOH O SUBSTRATE RECOGNITION SITES IN CYTOCHROME-P450 FAMILY-2 (CYP2) PROTEINS INFERRED FROM COMPARATIVE ANALYSES OF AMINO-ACID AND CODING NUCLEOTIDE-SEQUENCES	375	190
110	30	1926 1972 JOURNAL OF BIOLOGICAL CHEMISTRY 247(6):1727-& LU AYH; WEST S; CONNEY AH; KUNTZMAN R; JACOBSON M RECONSTITUTED LIVER MICROSOMAL ENZYME-SYSTEM THAT HYDROXYLATES DRUGS, OTHER FOREIGN COMPOUNDS, AND ENDOGENOUS SUBSTRATES .2. ROLE OF CYTOCHROME-P-450 AND P-448 FRACTIONS IN DRUG AND STEROID HYDROXYLATIONS	373	140
111	72	7895 1992 BIOCHEMICAL JOURNAL 281():577-592 WAXMAN DJ; AZAROFF L PHENOBARBITAL INDUCTION OF CYTOCHROME-P-450 GENE-EXPRESSION	370	121
112	14	1445 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 144(1):78-& WIEBEL FJ; LEUTZ JC; DIAMOND L; GELBOIN HV ARYL HYDROCARBON (BENZO[A]PYRENE) HYDROXYLASE IN MICROSOMES FROM RAT TISSUES - DIFFERENTIAL INHIBITION AND STIMULATION BY BENZOFLAVONES AND ORGANIC SOLVENTS	368	100
113	16	6820 1990 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 30():251-277 WHITLOCK JP GENETIC AND MOLECULAR ASPECTS OF 2,3,7,8-TETRACHLORODIBENZO-P- DIOXIN ACTION	367	49
114	1	438 1965 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 53(5):1076-& PRESSMAN BC INDUCED ACTIVE TRANSPORT OF IONS IN MITOCHONDRIA	365	11
115	13	5163 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(2):1239-1250 RYAN DE; IIDA S; WOOD AW; THOMAS PE; LIEBER CS; LEVIN W CHARACTERIZATION OF 3 HIGHLY PURIFIED CYTOCHROMES-P-450 FROM HEPATIC MICROSOMES OF ADULT MALE-RATS	364	135
116	1	236 1963 JOURNAL OF BIOLOGICAL CHEMISTRY 238(3):1124-& ERNSTER L; AZZONE GF; DALLNER G DIFFERENTIAL EFFECTS OF ROTENONE AND AMYTAL ON MITOCHONDRIAL ELECTRON AND ENERGY TRANSFER	361	83
117	15	3410 1977 JOURNAL OF LIPID RESEARCH 18(2):135-153 MYANT NB; MITROPOULOS KA CHOLESTEROL 7ALPHA-HYDROXYLASE	360	22
118	104	7261 1990 PHARMACOLOGY & THERAPEUTICS 45(2):153-239 RYAN DE; LEVIN W PURIFICATION AND CHARACTERIZATION OF HEPATIC-MICROSOMAL CYTOCHROME-P-450	358	174
119	11	2347 1973 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70(5):1321-1325 ALVARES AP; BICKERS DR; KAPPAS A POLYCHLORINATED BIPHENYLS - NEW TYPE OF INDUCER OF CYTOCHROME P-448 IN LIVER - (CYTOCHROME P-450 RATS ARYL HYDROCARBON HYDROXYLASE-ENZYME INDUCTION MICROSOMAL ENZYMES)	357	38
120	7	6360 1989 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 29():145-163 LOCK EA; MITCHELL AM; ELCOMBE CR BIOCHEMICAL-MECHANISMS OF INDUCTION OF HEPATIC PEROXISOME PROLIFERATION	354	41
121	29	1432 1971 ANNUAL REVIEW OF BIOCHEMISTRY 40():237-& HESS B; BOITEWX A OSCILLATORY PHENOMENA IN BIOCHEMISTRY	352	21
122	4	6716 1989 MOLECULAR PHARMACOLOGY 36(1):89-96 KRONBACH T; MATHYS D; UMENO M; GONZALEZ FJ; MEYER UA OXIDATION OF MIDAZOLAM AND TRIAZOLAM BY HUMAN-LIVER CYTOCHROME P450IIIA4	351	115
123	9	7025 1990 DRUG METABOLISM AND DISPOSITION 18(5):595-606 PICHARD L; FABRE I; FABRE G; DOMERGUE J; SAINTAUBERT B; MOURAD G; MAUREL P CYCLOSPORINE-A DRUG-INTERACTIONS - SCREENING FOR INDUCERS AND INHIBITORS OF CYTOCHROME-P-450 (CYCLOSPORINE-A OXIDASE) IN PRIMARY CULTURES OF HUMAN HEPATOCYTES AND IN LIVER-MICROSOMES	347	86
124	11	6640 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(18):10388-10395 AOYAMA T; YAMANO S; WAXMAN DJ; LAPENSON DP; MEYER UA; FISCHER V; TYNDALE R; INABA T; KALOW W; GELBOIN HV; GONZALEZ FJ CYTOCHROME-P-450 HPCN3, A NOVEL CYTOCHROME-P-450 IIIA-GENE PRODUCT THAT IS DIFFERENTIALLY EXPRESSED IN ADULT HUMAN-LIVER - CDNA AND DEDUCED AMINO-ACID SEQUENCE AND DISTINCT SPECIFICITIES OF CDNA-EXPRESSED HPCN1 AND HPCN3 FOR THE METABOLISM OF STEROID-HORMONES AND CYCLOSPORINEU	346	188
125	23	9099 1994 ENDOCRINE REVIEWS 15(3):342-355 SIMPSON ER; MAHENDROO MS; MEANS GD; KILGORE MW; HINSHELWOOD MM; GRAHAMLORENCE S; AMARNEH B; ITO YJ; FISHER CR; MICHAEL MD; MENDELSON CR; BULUN SE AROMATASE CYTOCHROME-P450, THE ENZYME RESPONSIBLE FOR ESTROGEN BIOSYNTHESIS	343	37
126	1	445 1966 ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 28():41-& STADTMAN ER ALLOSTERIC REGULATION OF ENZYME ACTIVITY	342	3
127	5	7981 1992 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 34(3):262-265 CREWE HK; LENNARD MS; TUCKER GT; WOODS FR; HADDOCK RE THE EFFECT OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS ON CYTOCHROME-P4502D6 (CYP2D6) ACTIVITY IN HUMAN LIVER-MICROSOMES	342	40
128	30	3238 1977 ANNUAL REVIEW OF BIOCHEMISTRY 46():201-262 DEPIERRE JW; ERNSTER L ENZYME TOPOLOGY OF INTRACELLULAR MEMBRANES	339	29
129	5	2417 1974 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 60(1):8-14 IMAI Y; SATO R GEL-ELECTROPHORETICALLY HOMOGENEOUS PREPARATION OF CYTOCHROME- P-450 FROM LIVER-MICROSOMES OF PHENOBARBITAL-PRETREATED RABBITS	334	115
130	1	436 1965 PHARMACOLOGICAL REVIEWS 17(2):71-& KAUFMAN S; FRIEDMAN S DOPAMINE-BETA-HYDROXYLASE	333	1
131	2	5717 1986 NEUROSCIENCE 18(2):261-& WINKLER H; APPS DK; FISCHERCOLBRIE R THE MOLECULAR FUNCTION OF ADRENAL CHROMAFFIN GRANULES - ESTABLISHED FACTS AND UNRESOLVED TOPICS	333	0
132	7	6230 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(13):6038-6050 NELSON DR; STROBEL HW ON THE MEMBRANE TOPOLOGY OF VERTEBRATE CYTOCHROME-P-450 PROTEINS	333	161
133	69	4346 1981 DRUG METABOLISM REVIEWS 12(1):1-117 TESTA B; JENNER P INHIBITORS OF CYTOCHROME P-450S AND THEIR MECHANISM OF ACTION	330	78
134	11	6111 1988 BIOCHEMISTRY 27(6):1925-1934 JOHANSSON I; EKSTROM G; SCHOLTE B; PUZYCKI D; JORNVALL H; INGELMANSUNDBERG M ETHANOL-INDUCIBLE, FASTING-INDUCIBLE, AND ACETONE-INDUCIBLE CYTOCHROMES-P-450 IN RAT-LIVER - REGULATION AND CHARACTERISTICS OF ENZYMES BELONGING TO THE IIB-GENE AND IIE-GENE SUBFAMILIES	330	110
135	8	2945 1976 ANALYTICAL BIOCHEMISTRY 75(2):596-603 MATSUBARA T; KOIKE M; TOUCHI A; TOCHINO Y; SUGENO K QUANTITATIVE-DETERMINATION OF CYTOCHROME-P-450 IN RAT-LIVER HOMOGENATE	325	45
136	5	5713 1986 MOLECULAR AND CELLULAR BIOLOGY 6(8):2969-2976 GONZALEZ FJ; SONG BJ; HARDWICK JP PREGNENOLONE 16-ALPHA-CARBONITRILE-INDUCIBLE P-450 GENE FAMILY - GENE CONVERSION AND DIFFERENTIAL REGULATION	325	186
137	2	107 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(3):845-852 YONETANI T STUDIES ON CYTOCHROME OXIDASE .1. ABSOLUTE AND DIFFERENCE ABSORPTION SPECTRA	323	32
138	1	328 1964 JOURNAL OF CELL BIOLOGY 22(1):63-& FERNANDEZMORAN H; ODA T; GREEN DE; BLAIR PV MACROMOLECULAR REPEATING UNIT OF MITOCHONDRIAL STRUCTURE + FUNCTION - CORRELATED ELECTRON MICROSCOPIC + BIOCHEMICAL STUDIES ISOLATED MITOCHONDRIA + SUBMITOCHONDRIAL PARTICLES OF BEEF HEART MUSCLE	321	19
139	1	1611 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(2):402-& PANDE SV; BLANCHAE.MC REVERSIBLE INHIBITION OF MITOCHONDRIAL ADENOSINE DIPHOSPHATE PHOSPHORYLATION BY LONG CHAIN ACYL COENZYME-A ESTERS	319	7
140	13	10616 1997 CHEMICAL REVIEWS 97(8):2879-2932 Shilov AE; Shul'pin GB Activation of C-H bonds by metal complexes	319	1
141	24	6025 1988 ANNUAL REVIEW OF PHYSIOLOGY 50():427-440 SIMPSON ER; WATERMAN MR REGULATION OF THE SYNTHESIS OF STEROIDOGENIC ENZYMES IN ADRENAL-CORTICAL CELLS BY ACTH	317	43
142	28	10168 1996 ENDOCRINE REVIEWS 17(3):221-244 Stocco DM; Clark BJ Regulation of the acute production of steroids in steroidogenic cells	316	15
143	5	5222 1984 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81(6):1696-1700 CHESIS PL; LEVIN DE; SMITH MT; ERNSTER L; AMES BN MUTAGENICITY OF QUINONES - PATHWAYS OF METABOLIC-ACTIVATION AND DETOXIFICATION	310	21
144	5	5225 1984 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81(23):7269-7273 ROSEN GM; FREEMAN BA DETECTION OF SUPEROXIDE GENERATED BY ENDOTHELIAL-CELLS	310	8
145	29	5531 1986 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 26():333-369 WHITLOCK JP THE REGULATION OF CYTOCHROME-P-450 GENE-EXPRESSION	310	95
146	9	4732 1982 XENOBIOTICA 12(11):727-744 RYAN DE; THOMAS PE; REIK LM; LEVIN W PURIFICATION, CHARACTERIZATION AND REGULATION OF 5 RAT HEPATIC- MICROSOMAL CYTOCHROME-P-450 ISOZYMES	309	100
147	5	1837 1972 BIOCHIMICA ET BIOPHYSICA ACTA 275(2):148-& DOUCE R; BONNER WD; CHRISTEN.EL PREPARATION OF INTACT PLANT MITOCHONDRIA	307	5
148	22	2966 1976 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 175(2):524-533 NORDBLOM GD; WHITE RE; COON MJ STUDIES ON HYDROPEROXIDE-DEPENDENT SUBSTRATE HYDROXYLATION BY PURIFIED LIVER MICROSOMAL CYTOCHROME-P-450	307	122
149	1	7597 1991 INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY 124():43-101 HIRSHFIELD AN DEVELOPMENT OF FOLLICLES IN THE MAMMALIAN OVARY	307	0
150	21	1427 1971 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 179(JUL6):43-& GILLETTE JR FACTORS AFFECTING DRUG METABOLISM	306	40
151	2	52 1959 BIOCHEMISCHE ZEITSCHRIFT 331(4):273-296 DELBRUCK A; ZEBE E; BUCHER T UBER VERTEILUNGSMUSTER VON ENZYMEN DES ENERGIE LIEFERNDEN STOFFWECHSELS IM FLUGMUSKEL, SPRUNGMUSKEL UND FETTKORPER VON LOCUSTA MIGRATORIA UND IHRE CYTOLOGISCHE ZUORDNUNG	305	23
152	10	145 1961 SCIENCE 134(348):1495-& BOXER GE; DEVLIN TM PATHWAYS OF INTRACELLULAR HYDROGEN TRANSPORT - ABSENCE OF ENZYMATIC HYDROGEN-CARRYING SYSTEMS IS A FACTOR IN AEROBIC GLYCOLYSIS OF MALIGNANT TISSUE	304	34
153	16	5910 1987 JOURNAL OF BIOLOGICAL CHEMISTRY 262(2):801-810 HARDWICK JP; SONG BJ; HUBERMAN E; GONZALEZ FJ ISOLATION, COMPLEMENTARY-DNA SEQUENCE, AND REGULATION OF RAT HEPATIC LAURIC ACID OMEGA-HYDROXYLASE (CYTOCHROME-P-450LA- OMEGA) - IDENTIFICATION OF A NEW CYTOCHROME-P-450 GENE FAMILY	304	151
154	1	8429 1993 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 191(1):89-94 NUNOKAWA Y; ISHIDA N; TANAKA S CLONING OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN RAT VASCULAR SMOOTH-MUSCLE CELLS	304	2
155	3	2980 1976 BIOCHEMICAL JOURNAL 154(2):327-348 KERBEY AL; RANDLE PJ; COOPER RH; WHITEHOUSE S; PASK HT; DENTON RM REGULATION OF PYRUVATE-DEHYDROGENASE IN RAT-HEART - MECHANISM OF REGULATION OF PROPORTIONS OF DEPHOSPHORYLATED AND PHOSPHORYLATED ENZYME BY OXIDATION OF FATTY-ACIDS AND KETONE- BODIES AND OF EFFECTS OF DIABETES - ROLE OF COENZYME-A, ACETYL- COENZYME-A AND REDUCED AND OXIDIZED NICOTINAMIDE-ADENINE DINUCLEOTIDEB	303	2
156	4	7796 1991 TRENDS IN NEUROSCIENCES 14(3):96-100 ORDWAY RW; SINGER JJ; WALSH JV DIRECT REGULATION OF ION CHANNELS BY FATTY-ACIDS	303	6
157	8	6290 1988 NEW ENGLAND JOURNAL OF MEDICINE 319(25):1639-1650 LIEBER CS BIOCHEMICAL AND MOLECULAR-BASIS OF ALCOHOL-INDUCED INJURY TO LIVER AND OTHER TISSUES	302	21
158	45	2603 1974 PHARMACOLOGICAL REVIEWS 26(3):171-197 CAMPBELL TC; HAYES JR ROLE OF NUTRITION IN DRUG-METABOLIZING ENZYME-SYSTEM	300	27
159	4	8319 1992 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89(23):11141-11145 MCMILLAN K; BREDT DS; HIRSCH DJ; SNYDER SH; CLARK JE; MASTERS BSS CLONED, EXPRESSED RAT CEREBELLAR NITRIC-OXIDE SYNTHASE CONTAINS STOICHIOMETRIC AMOUNTS OF HEME, WHICH BINDS CARBON-MONOXIDE	300	41
160	5	6033 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 263(2):424-436 WAXMAN DJ; ATTISANO C; GUENGERICH FP; LAPENSON DP HUMAN-LIVER MICROSOMAL STEROID-METABOLISM - IDENTIFICATION OF THE MAJOR MICROSOMAL STEROID-HORMONE 6-BETA-HYDROXYLASE CYTOCHROME-P-450 ENZYME	296	151
161	10	1123 1969 JOURNAL OF CELL BIOLOGY 42(1):92-& STAUBLI W; HESS R; WEIBEL ER CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON LIVER CELL .2. EFFECTS OF PHENOBARBITAL ON RAT HEPATOCYTES	295	13
162	14	3637 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(21):7931-7939 GUENGERICH FP SEPARATION AND PURIFICATION OF MULTIPLE FORMS OF MICROSOMAL CYTOCHROME-P-450 - PARTIAL CHARACTERIZATION OF 3 APPARENTLY HOMOGENEOUS CYTOCHROMES P-450 PREPARED FROM LIVERS OF PHENOBARBITAL-TREATED AND 3-METHYLCHOLANTHRENE-TREATED RATS	295	79
163	3	5208 1984 METHODS IN ENZYMOLOGY 105():283-293 SLATER TF OVERVIEW OF METHODS USED FOR DETECTING LIPID-PEROXIDATION	294	8
164	16	957 1969 ANNUAL REVIEW OF PHARMACOLOGY 9():21-& KUNTZMAN R DRUGS AND ENZYME INDUCTION	293	60
165	3	105 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(2):531-534 JACOBS EE; SANADI DR REVERSIBLE REMOVAL OF CYTOCHROME-C FROM MITOCHONDRIA	291	30
166	32	8347 1992 TRENDS IN PHARMACOLOGICAL SCIENCES 13(9):346-352 GONZALEZ FJ HUMAN CYTOCHROMES-P450 - PROBLEMS AND PROSPECTS	291	111
167	21	4208 1980 PHYSIOLOGICAL REVIEWS 60(2):551-613 FRASER DR REGULATION OF THE METABOLISM OF VITAMIN-D	290	4
168	10	543 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(21):5026-& WILLIAMS.JR GLYCOLYTIC CONTROL MECHANISMS .2. KINETICS OF INTERMEDIATE CHANGES DURING AEROBIC-ANOXIC TRANSITION IN PERFUSED RAT HEART	289	0
169	4	6593 1989 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 36(6):537-547 BROSEN K; GRAM LF CLINICAL-SIGNIFICANCE OF THE SPARTEINE-DEBRISOQUINE OXIDATION POLYMORPHISM	288	50
170	13	7447 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1057(3):281-298 CROSS AR; JONES OTG ENZYMATIC MECHANISMS OF SUPEROXIDE PRODUCTION	288	0
171	9	7611 1991 JOURNAL OF BIOCHEMISTRY 110(3):407-411 HAYASHI S; WATANABE J; NAKACHI K; KAWAJIRI K GENETIC-LINKAGE OF LUNG CANCER-ASSOCIATED MSPI POLYMORPHISMS WITH AMINO-ACID REPLACEMENT IN THE HEME BINDING REGION OF THE HUMAN CYTOCHROME-P450IA1 GENE	285	38
172	19	1993 1972 PHARMACOLOGICAL REVIEWS 24(1):67-& HAWKINS RD; KALANT H METABOLISM OF ETHANOL AND ITS METABOLIC EFFECTS	284	8
173	28	6542 1989 CRITICAL REVIEWS IN TOXICOLOGY 20(3):153-174 NEBERT DW THE AH LOCUS - GENETIC-DIFFERENCES IN TOXICITY, CANCER, MUTATION, AND BIRTH-DEFECTS	283	62
174	3	6761 1989 SCIENCE 244(4909):1176-1179 ORDWAY RW; WALSH JV; SINGER JJ ARACHIDONIC-ACID AND OTHER FATTY-ACIDS DIRECTLY ACTIVATE POTASSIUM CHANNELS IN SMOOTH-MUSCLE CELLS	283	5
175	39	4250 1981 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 21():431-462 NEBERT DW; EISEN HJ; NEGISHI M; LANG MA; HJELMELAND LM; OKEY AB GENETIC MECHANISMS CONTROLLING THE INDUCTION OF POLYSUBSTRATE MONO-OXYGENASE (P-450) ACTIVITIES	282	50
176	6	5526 1986 AMERICAN JOURNAL OF PHYSIOLOGY 250(5):H815-H821 RUBANYI GM; VANHOUTTE PM OXYGEN-DERIVED FREE-RADICALS, ENDOTHELIUM, AND RESPONSIVENESS OF VASCULAR SMOOTH-MUSCLE	282	1
177	3	7070 1990 FEBS LETTERS 263(1):131-133 KAWAJIRI K; NAKACHI K; IMAI K; YOSHII A; SHINODA N; WATANABE J IDENTIFICATION OF GENETICALLY HIGH-RISK INDIVIDUALS TO LUNG- CANCER BY DNA POLYMORPHISMS OF THE CYTOCHROME-P450IA1 GENE	282	47
178	14	2124 1973 BIOCHEMISTRY 12(12):2297-2308 IYANAGI T; MASON HS SOME PROPERTIES OF HEPATIC REDUCED NICOTINAMIDE ADENINE- DINUCLEOTIDE PHOSPHATE - CYTOCHROME-C REDUCTASE	279	81
179	5	2132 1973 BIOCHIMICA ET BIOPHYSICA ACTA 301(1):71-104 TZAGOLOF.A; RUBIN MS; SIERRA MF BIOSYNTHESIS OF MITOCHONDRIAL ENZYMES	279	0
180	13	4763 1983 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 225(2):758-770 KAMATAKI T; MAEDA K; YAMAZOE Y; NAGAI T; KATO R SEX DIFFERENCE OF CYTOCHROME-P-450 IN THE RAT - PURIFICATION, CHARACTERIZATION, AND QUANTITATION OF CONSTITUTIVE FORMS OF CYTOCHROME-P-450 FROM LIVER-MICROSOMES OF MALE AND FEMALE RATS	279	96
181	13	1406 1970 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 66(4):1157-& TSAI R; YU CA; GUNSALUS IC; PEISACH J; BLUMBERG W; ORMEJOHN.WH; BEINERT H SPIN-STATE CHANGES IN CYTOCHROME-P-450CAM ON BINDING OF SPECIFIC SUBSTRATES	278	104
182	7	4983 1983 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80(3):702-706 PRIVALLE CT; CRIVELLO JF; JEFCOATE CR REGULATION OF INTRAMITOCHONDRIAL CHOLESTEROL TRANSFER TO SIDE- CHAIN CLEAVAGE CYTOCHROME-P-450 IN RAT ADRENAL-GLAND	278	24
183	8	1606 1971 JOURNAL OF BIOCHEMISTRY 69(1):155-& OSHINO N; IMAI Y; SATO R FUNCTION OF CYTOCHROME-B5 IN FATTY ACID DESATURATION BY RAT LIVER MICROSOMES	277	108
184	8	10860 1997 PHARMACOGENETICS 7(4):255-269 Mackenzie PI; Owens IS; Burchell B; Bock KW; Bairoch A; Belanger A; FournelGigleux S; Green M; Hum DW; Iyanagi T; Lancet D; Louisot P; Magdalou J; Chowdhury JR; Ritter JK; Schachter H; Tephly TR; Tipton KF; Nebert DW The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence	277	16
185	22	8199 1992 JOURNAL OF CLINICAL INVESTIGATION 90(5):1871-1878 KOLARS JC; SCHMIEDLINREN P; SCHUETZ JD; FANG C; WATKINS PB IDENTIFICATION OF RIFAMPIN-INDUCIBLE P450IIIA4 (CYP3A4) IN HUMAN SMALL-BOWEL ENTEROCYTES	276	50
186	3	134 1961 JOURNAL OF BIOLOGICAL CHEMISTRY 236(6):1850-& GRIFFITHS D; WHARTON DC STUDIES OF ELECTRON TRANSPORT SYSTEM .35. PURIFICATION AND PROPERTIES OF CYTOCHROME OXIDASE	275	0
187	8	496 1966 BIOCHIMICA ET BIOPHYSICA ACTA 128(1):13-& OSHINO N; IMAI Y; SATO R ELECTRON-TRANSFER MECHANISM ASSOCIATED WITH FATTY ACID DESATURATION CATALYZED BY LIVER MICROSOMES	275	65
188	3	2290 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(14):4987-4997 EINARSSO.K; GUSTAFSS.JA; STENBERG A NEONATAL IMPRINTING OF LIVER MICROSOMAL HYDROXYLATION AND REDUCTION OF STEROIDS	275	0
189	5	6748 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(2):462-465 SHIMADA T; GUENGERICH FP EVIDENCE FOR CYTOCHROME-P-450NF, THE NIFEDIPINE OXIDASE, BEING THE PRINCIPAL ENZYME INVOLVED IN THE BIOACTIVATION OF AFLATOXINS IN HUMAN-LIVER	274	127
190	6	8460 1993 BIOCHEMICAL PHARMACOLOGY 45(6):1211-1214 BROSEN K; SKJELBO E; RASMUSSEN BB; POULSEN HE; LOFT S FLUVOXAMINE IS A POTENT INHIBITOR OF CYTOCHROME-P4501A2	274	49
191	20	8802 1993 PHARMACOGENETICS 3(5):213-230 SWANSON HI; BRADFIELD CA THE AH-RECEPTOR - GENETICS, STRUCTURE AND FUNCTION	274	32
192	70	10629 1997 CLINICAL PHARMACOKINETICS 32(3):210-258 Bertz RJ; Granneman GR Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions	274	37
193	28	7844 1992 AQUATIC TOXICOLOGY 22(4):287-311 GOKSOYR A; FORLIN L THE CYTOCHROME-P-450 SYSTEM IN FISH, AQUATIC TOXICOLOGY AND ENVIRONMENTAL MONITORING	273	49
194	7	1805 1972 BIOCHEMICAL PHARMACOLOGY 21(24):3249-& CINTI DL; SCHENKMAN JB; MOLDEUS P KINETIC PARAMETERS OF DRUG-METABOLIZING ENZYMES IN CA2+ - SEDIMENTED MICROSOMES FROM RAT-LIVER	271	67
195	12	6911 1990 BIOCHEMISTRY 29(5):1322-1329 YAMANO S; TATSUNO J; GONZALEZ FJ THE CYP2A3-GENE PRODUCT CATALYZES COUMARIN 7-HYDROXYLATION IN HUMAN LIVER-MICROSOMES	271	121
196	115	10668 1997 DRUG METABOLISM REVIEWS 29(1-2):413-580 Rendic S; DiCarlo FJ Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors	271	82
197	14	6311 1988 PROGRESS IN LIPID RESEARCH 27(4):271-323 SPECTOR AA; GORDON JA; MOORE SA HYDROXYEICOSATETRAENOIC ACIDS (HETES)	270	14
198	6	7181 1990 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 253(1):387-394 DEWAZIERS I; CUGNENC PH; YANG CS; LEROUX JP; BEAUNE PH CYTOCHROME-P-450 ISOENZYMES, EPOXIDE HYDROLASE AND GLUTATHIONE TRANSFERASES IN RAT AND HUMAN HEPATIC AND EXTRAHEPATIC TISSUES	270	86
199	13	8985 1994 BIOCHEMISTRY 33(7):1743-1752 GOLDSTEIN JA; FALETTO MB; ROMKESSPARKS M; SULLIVAN T; KITAREEWAN S; RAUCY JL; LASKER JM; GHANAYEM BI EVIDENCE THAT CYP2C19 IS THE MAJOR (S)-MEPHENYTOIN 4'- HYDROXYLASE IN HUMANS	270	70
200	7	6556 1989 DRUG METABOLISM AND DISPOSITION 17(2):197-207 COMBALBERT J; FABRE I; FABRE G; DALET I; DERANCOURT J; CANO JP; MAUREL P METABOLISM OF CYCLOSPORINE-A .4. PURIFICATION AND IDENTIFICATION OF THE RIFAMPICIN-INDUCIBLE HUMAN-LIVER CYTOCHROME-P-450 (CYCLOSPORINE-A OXIDASE) AS A PRODUCT OF P450IIIA GENE SUBFAMILY	269	97

#	Cited nodes	Nodes / Authors	GCS	LCS
201	2	695 1967 JOURNAL OF CELL BIOLOGY 34(1):1-& CLARKWAL.GD; LINNANE AW BIOGENESIS OF MITOCHONDRIA IN SACCHAROMYCES CEREVISIAE	268	0
202	14	4636 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(17):446-457 WAXMAN DJ; WALSH C PHENOBARBITAL-INDUCED RAT-LIVER CYTOCHROME-P-450 - PURIFICATION AND CHARACTERIZATION OF 2 CLOSELY RELATED ISOZYMIC FORMS	268	0
203	4	5472 1985 NATURE 314(6012):620-622 SCHWARTZMAN M; FERRERI NR; CARROLL MA; SONGUMIZE E; MCGIFF JC RENAL CYTOCHROME-P450-RELATED ARACHIDONATE METABOLITE INHIBITS (NA+ + K+)ATPASE	268	104
204	29	5857 1987 CHEMICAL REVIEWS 87(5):1255-1276 DAWSON JH; SONO M CYTOCHROME.P-450 AND CHLOROPEROXIDASE - THIOLATE-LIGATED HEME ENZYMES - SPECTROSCOPIC DETERMINATION OF THEIR ACTIVE-SITE STRUCTURES AND MECHANISTIC IMPLICATIONS OF THIOLATE LIGATION	268	26
205	1	3927 1979 MOLECULAR PHARMACOLOGY 16(2):676-685 FINKELSTEIN E; ROSEN GM; RAUCKMAN EJ; PAXTON J SPIN TRAPPING OF SUPEROXIDE	267	14
206	17	8119 1992 FREE RADICAL BIOLOGY AND MEDICINE 12(3):219-240 NORDMANN R; RIBIERE C; ROUACH H IMPLICATION OF FREE-RADICAL MECHANISMS IN ETHANOL-INDUCED CELLULAR INJURY	266	10
207	18	4504 1982 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 216(1):272-288 RYAN DE; THOMAS PE; LEVIN W PURIFICATION AND CHARACTERIZATION OF A MINOR FORM OF HEPATIC- MICROSOMAL CYTOCHROME-P-450 FROM RATS TREATED WITH POLYCHLORINATED-BIPHENYLS	265	98
208	7	3798 1979 BIOCHIMICA ET BIOPHYSICA ACTA 549(2):177-222 WIKSTROM M; KRAB K PROTON-PUMPING CYTOCHROME-C OXIDASE	262	4
209	6	430 1965 JOURNAL OF CELL BIOLOGY 26(3):713-& ORRENIUS S ON MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES	260	116
210	14	5978 1987 PURE AND APPLIED CHEMISTRY 59(6):759-770 MANSUY D CYTOCHROME-P-450 AND SYNTHETIC MODELS	260	10
211	2	39 1958 JOURNAL OF BIOLOGICAL CHEMISTRY 233(4):1014-1019 ESTABROOK RW; SACKTOR B ALPHA-GLYCEROPHOSPHATE OXIDASE OF FLIGHT MUSCLE MITOCHONDRIA	259	259
212	7	2677 1975 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 171(2):385-397 HILDEBRANDT AG; ROOTS I REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH)- DEPENDENT FORMATION AND BREAKDOWN OF HYDROGEN-PEROXIDE DURING MIXED-FUNCTION OXIDATION REACTIONS IN LIVER-MICROSOMES	258	83
213	14	2559 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(17):5599-5606 POLAND AP; GLOVER E; ROBINSON JR; NEBERT DW GENETIC EXPRESSION OF ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY - INDUCTION OF MONOOXYGENASE ACTIVITIES AND CYTOCHROME P1-450 FORMATION BY 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN IN MICE GENETICALLY NONRESPONSIVE TO OTHER AROMATIC-HYDROCARBON	257	43
214	12	6497 1989 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 28(4):373-387 GED C; ROUILLON JM; PICHARD L; COMBALBERT J; BRESSOT N; BORIES P; MICHEL H; BEAUNE P; MAUREL P THE INCREASE IN URINARY-EXCRETION OF 6-BETA-HYDROXYCORTISOL AS A MARKER OF HUMAN HEPATIC CYTOCHROME-P450IIIA INDUCTION	257	75
215	12	7037 1990 DRUG METABOLISM REVIEWS 22(2-3):147-159 YANG CS; YOO JSH; ISHIZAKI H; HONG JY CYTOCHROME-P450IIE1 - ROLES IN NITROSAMINE METABOLISM AND MECHANISMS OF REGULATION	256	68
216	5	894 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(12):3543-& KATAGIRI M; GANGULI BN; GUNSALUS IC A SOLUBLE CYTOCHROME P-450 FUNCTIONAL IN METHYLENE HYDROXYLATION	255	126
217	4	9296 1994 MOLECULAR ENDOCRINOLOGY 8(5):654-662 IKEDA Y; SHEN WH; INGRAHAM HA; PARKER KL DEVELOPMENTAL EXPRESSION OF MOUSE STEROIDOGENIC FACTOR-I, AN ESSENTIAL REGULATOR OF THE STEROID HYDROXYLASES	255	14
218	18	4839 1983 CHEMICO-BIOLOGICAL INTERACTIONS 45(2):243-258 BURKE MD; MAYER RT DIFFERENTIAL-EFFECTS OF PHENOBARBITONE AND 3-METHYLCHOLANTHRENE INDUCTION ON THE HEPATIC-MICROSOMAL METABOLISM AND CYTOCHROME P-450-BINDING OF PHENOXAZONE AND A HOMOLOGOUS SERIES OF ITS NORMAL-ALKYL ETHERS (ALKOXYRESORUFINS)	254	57
219	5	6659 1989 JOURNAL OF CLINICAL INVESTIGATION 83(2):688-697 WATKINS PB; MURRAY SA; WINKELMAN LG; HEUMAN DM; WRIGHTON SA; GUZELIAN PS ERYTHROMYCIN BREATH TEST AS AN ASSAY OF GLUCOCORTICOID- INDUCIBLE LIVER CYTOCHROMES P-450 - STUDIES IN RATS AND PATIENTS	254	78
220	48	7258 1990 PHARMACOLOGICAL REVIEWS 42(2):85-101 MURRAY M; REIDY GF SELECTIVITY IN THE INHIBITION OF MAMMALIAN CYTOCHROMES-P-450 BY CHEMICAL-AGENTS	254	92
221	1	151 1962 ANALYTICAL BIOCHEMISTRY 3(5):369-& ESTABROOK RW; MAITRA PK A FLUORIMETRIC METHOD FOR QUANTITATIVE MICROANALYSIS OF ADENINE AND PYRIDINE NUCLEOTIDES	252	252
222	54	2462 1974 BIOCHIMICA ET BIOPHYSICA ACTA 344(2):205-240 LU AYH; LEVIN W RESOLUTION AND RECONSTITUTION OF LIVER MICROSOMAL HYDROXYLATION SYSTEM	252	87
223	5	6382 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 271(2):270-283 RAUCY JL; LASKER JM; LIEBER CS; BLACK M ACETAMINOPHEN ACTIVATION BY HUMAN-LIVER CYTOCHROMES P450IIE1 AND P450IA2	252	52
224	4	7762 1991 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88(13):5597-5601 BARNES HJ; ARLOTTO MP; WATERMAN MR EXPRESSION AND ENZYMATIC-ACTIVITY OF RECOMBINANT CYTOCHROME- P450 17-ALPHA-HYDROXYLASE IN ESCHERICHIA-COLI	252	165
225	4	3233 1977 AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 129(1):69-103 LONGO LD BIOLOGICAL EFFECTS OF CARBON-MONOXIDE ON PREGNANT WOMAN, FETUS, AND NEWBORN-INFANT	250	1
226	7	5074 1984 BIOCHIMICA ET BIOPHYSICA ACTA 768(1):53-79 RICH PR ELECTRON AND PROTON TRANSFERS THROUGH QUINONES AND CYTOCHROME- BC COMPLEXES	250	1
227	21	6362 1989 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 29():241-264 GUENGERICH FP CHARACTERIZATION OF HUMAN MICROSOMAL CYTOCHROME-P-450 ENZYMES	250	110
228	9	7314 1990 TRENDS IN GENETICS 6(6):182-186 GONZALEZ FJ; NEBERT DW EVOLUTION OF THE P450-GENE SUPERFAMILY - ANIMAL PLANT WARFARE, MOLECULAR DRIVE AND HUMAN GENETIC-DIFFERENCES IN DRUG OXIDATION	250	124
229	12	2071 1973 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 158(2):842-852 LEVIN W; LU AYH; JACOBSON M; KUNTZMAN R; POYER JL; MCCAY PB LIPID PEROXIDATION AND DEGRADATION OF CYTOCHROME-P-450 HEME	249	38
230	9	5485 1985 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 45(1):1-56 MATHEWS FS THE STRUCTURE, FUNCTION AND EVOLUTION OF CYTOCHROMES	247	9
231	5	7527 1991 DNA AND CELL BIOLOGY 10(7):487-494 BURCHELL B; NEBERT DW; NELSON DR; BOCK KW; IYANAGI T; JANSEN PLM; LANCET D; MULDER GJ; CHOWDHURY JR; SIEST G; TEPHLY TR; MACKENZIE PI THE UDP GLUCURONOSYLTRANSFERASE GENE SUPERFAMILY - SUGGESTED NOMENCLATURE BASED ON EVOLUTIONARY DIVERGENCE	247	31
232	8	2006 1972 SCIENCE 178(4061):576-& CONNEY AH; BURNS JJ METABOLIC INTERACTIONS AMONG ENVIRONMENTAL CHEMICALS AND DRUGS	246	23
233	10	6433 1989 BIOCHEMICAL PHARMACOLOGY 38(8):1313-1319 EKSTROM G; INGELMANSUNDBERG M RAT-LIVER MICROSOMAL NADPH-SUPPORTED OXIDASE ACTIVITY AND LIPID-PEROXIDATION DEPENDENT ON ETHANOL-INDUCIBLE CYTOCHROME-P- 450 (P-450IIE1)	246	34
234	9	8178 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(25):17913-17919 MOROHASHI K; HONDA S; INOMATA Y; HANDA H; OMURA T A COMMON TRANS-ACTING FACTOR, AD4-BINDING PROTEIN, TO THE PROMOTERS OF STEROIDOGENIC P-450S	246	27
235	6	234 1963 JOURNAL OF BIOLOGICAL CHEMISTRY 238(1):418-& CHANCE B; HOLLUNGER G INHIBITION OF ELECTRON AND ENERGY TRANSFER IN MITOCHONDRIA .1. EFFECTS OF AMYTAL, THIOPENTAL, ROTENONE, PROGESTERONE, AND METHYLENE GLYCOL	245	58
236	15	1449 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 144(2):678-& PETERSON JA CAMPHOR BINDING BY PSEUDOMONAS-PUTIDA CYTOCHROME P-450	245	139
237	12	6967 1990 CANCER RESEARCH 50(11):3367-3376 MCMANUS ME; BURGESS WM; VERONESE ME; HUGGETT A; QUATTROCHI LC; TUKEY RH METABOLISM OF 2-ACETYLAMINOFLUORENE AND BENZO(A)PYRENE AND ACTIVATION OF FOOD-DERIVED HETEROCYCLIC AMINE MUTAGENS BY HUMAN CYTOCHROMES-P-450	245	75
238	4	9834 1995 PHARMACOGENETICS 5(1):1-17 VATSIS KP; WEBER WW; BELL DA; DUPRET JM; EVANS DAP; GRANT DM; HEIN DW; LIN HJ; MEYER UA; RELLING MV; SIM E; SUZUKI T; YAMAZOE Y NOMENCLATURE FOR N-ACETYLTRANSFERASES	245	20
239	5	5970 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(2):407-411 CHUNG BC; PICADOLEONARD J; HANIU M; BIENKOWSKI M; HALL PF; SHIVELY JE; MILLER WL CYTOCHROME P450C17 (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - CLONING OF HUMAN ADRENAL AND TESTIS CDNAS INDICATES THE SAME GENE IS EXPRESSED IN BOTH TISSUES	243	72
240	4	6653 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(35):20961-20967 MORNET E; DUPONT J; VITEK A; WHITE PC CHARACTERIZATION OF 2 GENES ENCODING HUMAN STEROID 11-BETA- HYDROXYLASE (P-45011-BETA)	243	57
241	5	10095 1996 CELL 85(2):171-182 Szekeres M; Nemeth K; KonczKalman Z; Mathur J; Kauschmann A; Altmann T; Redei GP; Nagy F; Schell J; Koncz C Brassinosteroids rescue the deficiency of CYP90, a cytochrome P450, controlling cell elongation and de-etiolation in arabidopsis	243	19
242	8	4523 1982 BIOCHEMICAL JOURNAL 203(1):161-168 GIBSON GG; ORTON TC; TAMBURINI PP CYTOCHROME-P-450 INDUCTION BY CLOFIBRATE - PURIFICATION AND PROPERTIES OF A HEPATIC CYTOCHROME-P-450 RELATIVELY SPECIFIC FOR THE 12-HYDROXYLATION AND 11-HYDROXYLATION OF DODECANOIC ACID (LAURIC-ACID)	242	71
243	5	10696 1997 EUROPEAN JOURNAL OF BIOCHEMISTRY 247(2):725-732 McCoubrey WK; Huang TJ; Maines MD Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3	241	3
244	1	68 1959 JOURNAL OF BIOLOGICAL CHEMISTRY 234(11):3051-3054 LEE YP; TAKEMORI AE; LARDY H ENHANCED OXIDATION OF ALPHA-GLYCEROPHOSPHATE BY MITOCHONDRIA OF THYROID-FED RATS	240	40
245	12	3338 1977 DRUG METABOLISM AND DISPOSITION 5(1):1-8 BURKE MD; PROUGH RA; MAYER RT CHARACTERISTICS OF A MICROSOMAL CYTOCHROME P-448-MEDIATED REACTION ETHOXYRESORUFIN O-DE-ETHYLATION	240	70
246	3	7008 1990 CRITICAL REVIEWS IN IMMUNOLOGY 10(1):1-12 FORDHUTCHINSON AW LEUKOTRIENE-B4 IN INFLAMMATION	238	5
247	1	372 1965 BIOCHEMICAL JOURNAL 97(2):587-& GARLAND PB; SHEPHERD D; YATES DW STEADY-STATE CONCENTRATIONS OF COENZYME A ACETYL-COENZYME A AND LONG-CHAIN FATTY ACYL-COENZYME A IN RAT-LIVER MITOCHONDRIA OXIDIZING PALMITATE	237	9
248	64	3464 1977 XENOBIOTICA 7(1-2):25-92 KATO R DRUG-METABOLISM UNDER PATHOLOGICAL AND ABNORMAL PHYSIOLOGICAL STATES IN ANIMALS AND MAN	236	32
249	6	1328 1970 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 18(5):753-& CASIDA JE MIXED-FUNCTION OXIDASE INVOLVEMENT IN BIOCHEMISTRY OF INSECTICIDE SYNERGISTS	235	24
250	17	4750 1983 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 23():481-503 DEMONTELLANO PRO; CORREIA MA SUICIDAL DESTRUCTION OF CYTOCHROME-P-450 DURING OXIDATIVE DRUG- METABOLISM	235	50
251	3	686 1967 JOURNAL OF BIOLOGICAL CHEMISTRY 242(3):485-& KIMURA T; SUZUKI K COMPONENTS OF ELECTRON TRANSPORT SYSTEM IN ADRENAL STEROID HYDROXYLASE - ISOLATION AND PROPERTIES OF NON-HEME IRON PROTEIN (ADRENODOXIN)	234	137
252	36	268 1964 ANNUAL REVIEW OF BIOCHEMISTRY 33():729-& ERNSTER L; LEE CP BIOLOGICAL OXIDOREDUCTIONS	233	46
253	8	561 1966 PHARMACOLOGICAL REVIEWS 18(3):1091-& KIESE M BIOCHEMICAL PRODUCTION OF FERRIHEMOGLOBIN-FORMING DERIVATIVES FROM AROMATIC AMINES AND MECHANISMS OF FERRIHEMOGLOBIN FORMATION	233	15
254	3	6349 1989 AMERICAN JOURNAL OF HUMAN GENETICS 45(6):889-904 KIMURA S; UMENO M; SKODA RC; MEYER UA; GONZALEZ FJ THE HUMAN DEBRISOQUINE 4-HYDROXYLASE (CYP2D) LOCUS - SEQUENCE AND IDENTIFICATION OF THE POLYMORPHIC CYP2D6 GENE, A RELATED GENE, AND A PSEUDOGENE	233	63
255	5	2165 1973 CANCER RESEARCH 33(11):2983-2986 CZYGAN P; GREIM H; GARRO AJ; HUTTERER F; SCHAFFNE.F; POPPER H; ROSENTHA.O; COOPER DY MICROSOMAL METABOLISM OF DIMETHYLNITROSAMINE AND CYTOCHROME-P- 450 DEPENDENCY OF ITS ACTIVATION TO A MUTAGEN	232	23
256	6	2226 1973 EUROPEAN JOURNAL OF BIOCHEMISTRY 34(2):358-368 KROGER A; KLINGENB.M; SCHWEIDL.S KINETICS OF REDOX REACTIONS OF UBIQUINONE RELATED TO ELECTRON- TRANSPORT ACTIVITY IN RESPIRATORY CHAIN	232	6
257	5	6308 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(23):8948-8952 CORBIN CJ; GRAHAMLORENCE S; MCPHAUL M; MASON JI; MENDELSON CR; SIMPSON ER ISOLATION OF A FULL-LENGTH CDNA INSERT ENCODING HUMAN AROMATASE SYSTEM CYTOCHROME-P-450 AND ITS EXPRESSION IN NONSTEROIDOGENIC CELLS	231	58
258	6	7134 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(14):8190-8197 JELINEK DF; ANDERSSON S; SLAUGHTER CA; RUSSELL DW CLONING AND REGULATION OF CHOLESTEROL 7-ALPHA-HYDROXYLASE, THE RATE-LIMITING ENZYME IN BILE-ACID BIOSYNTHESIS	231	22
259	4	8180 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(27):19051-19053 MUERHOFF AS; GRIFFIN KJ; JOHNSON EF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR MEDIATES THE INDUCTION OF CYP4A6, A CYTOCHROME-P450 FATTY-ACID OMEGA- HYDROXYLASE, BY CLOFIBRIC ACID	231	35
260	7	904 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(23):6250-& NEBERT DW; GELBOIN HV SUBSTRATE-INDUCIBLE MICROSOMAL ARYL HYDROXYLASE IN MAMMALIAN CELL CULTURE .2. CELLULAR RESPONSES DURING ENZYME INDUCTION	229	36
261	11	1019 1969 BIOCHEMISTRY 8(8):3455-& JEFCOATE CR; GAYLOR JL; CALABRES.RL LIGAND INTERACTIONS WITH CYTOCHROME P-450 .I. BINDING OF PRIMARY AMINES	229	0
262	35	1157 1969 PHYSIOLOGICAL REVIEWS 49(1):48-& LEMBERG MR CYTOCHROME OXIDASE	229	11
263	10	7241 1990 MOLECULAR PHARMACOLOGY 38(2):207-213 WRIGHTON SA; BRIAN WR; SARI MA; IWASAKI M; GUENGERICH FP; RAUCY JL; MOLOWA DT; VANDENBRANDEN M STUDIES ON THE EXPRESSION AND METABOLIC CAPABILITIES OF HUMAN LIVER CYTOCHROME P450IIIA5 (HLP3)	229	109
264	41	7352 1991 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 31():339-369 MCGIFF JC CYTOCHROME-P-450 METABOLISM OF ARACHIDONIC-ACID	227	99
265	15	1885 1972 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 5(2):116-136 REMMER H INDUCTION OF DRUG-METABOLIZING ENZYME-SYSTEM IN LIVER	226	28
266	2	4644 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(7):3771-3781 OLIW EH; GUENGERICH FP; OATES JA OXYGENATION OF ARACHIDONIC-ACID BY HEPATIC MONO-OXYGENASES - ISOLATION AND METABOLISM OF 4 EPOXIDE INTERMEDIATES	226	169
267	10	4645 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(23):3951-3957 MORGAN ET; KOOP DR; COON MJ CATALYTIC ACTIVITY OF CYTOCHROME-P-450 ISOZYME-3A ISOLATED FROM LIVER-MICROSOMES OF ETHANOL TREATED RABBITS - OXIDATION OF ALCOHOLS	226	0
268	26	3920 1979 MOLECULAR AND CELLULAR ENDOCRINOLOGY 13(3):213-227 SIMPSON ER CHOLESTEROL SIDE-CHAIN CLEAVAGE, CYTOCHROME-P450, AND THE CONTROL OF STEROIDOGENESIS	225	42
269	7	7655 1991 JOURNAL OF CLINICAL INVESTIGATION 88(4):1370-1378 MANNS MP; GRIFFIN KJ; SULLIVAN KF; JOHNSON EF LKM-1 AUTOANTIBODIES RECOGNIZE A SHORT LINEAR SEQUENCE IN P450IID6, A CYTOCHROME-P-450 MONOOXYGENASE	225	15
270	30	8544 1993 CANCER RESEARCH 53(23):5629-5637 CHANG TKH; WEBER GF; CRESPI CL; WAXMAN DJ DIFFERENTIAL ACTIVATION OF CYCLOPHOSPHAMIDE AND IFOSPHAMIDE BY CYTOCHROME-P-450-2B AND CYTOCHROME-P450-3A IN HUMAN LIVER- MICROSOMES	225	55
271	22	2289 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(14):4947-4955 COMAI K; GAYLOR JL EXISTENCE AND SEPARATION OF 3 FORMS OF CYTOCHROME-P-450 FROM RAT-LIVER MICROSOMES	224	115
272	19	2859 1975 JOURNAL OF CELLULAR PHYSIOLOGY 85(2):393-414 NEBERT DW; ROBINSON JR; NIWA A; KUMAKI K; POLAND AP GENETIC EXPRESSION OF ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY IN MOUSE	224	21
273	7	400 1965 BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY 40(3):422-& DINGLE JT; LUCY JA VITAMIN A CAROTENOIDS AND CELL FUNCTION	223	0
274	4	2288 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(10):3441-3445 BAHR JT; BONNER WD CYANIDE-INSENSITIVE RESPIRATION .1. STEADY STATES OF SKUNK CABBAGE SPADIX AND BEAN HYPOCOTYL MITOCHONDRIA	223	4
275	20	1896 1972 FEDERATION PROCEEDINGS 31(4):1315-& NEBERT DW; GIELEN JE GENETIC REGULATION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION IN MOUSE	222	32
276	10	1622 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(13):4143-& MASTERS BSS; BARON J; TAYLOR WE; ISAACSON EL; LOSPALLU.J IMMUNOCHEMICAL STUDIES ON ELECTRON TRANSPORT CHAINS INVOLVING CYTOCHROME P-450 .1. EFFECTS OF ANTIBODIES TO PIG LIVER MICROSOMAL REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME-C REDUCTASE AND NON-HEME IRON PROTEIN FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	221	96
277	2	7253 1990 NATURE 347(6295):773-776 GOUGH AC; MILES JS; SPURR NK; MOSS JE; GAEDIGK A; EICHELBAUM M; WOLF CR IDENTIFICATION OF THE PRIMARY GENE DEFECT AT THE CYTOCHROME- P450 CYP2D LOCUS	221	52
278	8	7276 1990 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87(12):4790-4793 AOYAMA T; YAMANO S; GUZELIAN PS; GELBOIN HV; GONZALEZ FJ 5 OF 12 FORMS OF VACCINIA VIRUS-EXPRESSED HUMAN HEPATIC CYTOCHROME-P450 METABOLICALLY ACTIVATE AFLATOXIN-B1	220	99
279	4	9682 1995 GASTROENTEROLOGY 109(1):285-301 EBERHART CE; DUBOIS RN EICOSANOIDS AND THE GASTROINTESTINAL-TRACT	220	2
280	10	10678 1997 ENDOCRINE REVIEWS 18(3):361-377 Parker KL; Schimmer BP Steroidogenic factor 1: A key determinant of endocrine development and function	220	3
281	5	613 1967 BIOCHEMICAL JOURNAL 103(1):55-& SMUCKLER EA; ARRHENIU.E; HULTIN T ALTERATIONS IN MICROSOMAL ELECTRON TRANSPORT OXIDATIVE N- DEMETHYLATION AND AZO-DYE CLEAVAGE IN CARBON TETRACHLORIDE AND DIMETHYLNITROSAMINE-INDUCED LIVER INJURY	218	39
282	8	775 1968 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 30(6):607-& HILDEBRANDT A; REMMER H; ESTABROOK RW CYTOCHROME P-450 OF LIVER MICROSOMES - 1 PIGMENT OR MANY	218	218
283	10	4450 1981 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78(9):5362-5366 CAPDEVILA J; CHACOS N; WERRINGLOER J; PROUGH RA; ESTABROOK RW LIVER MICROSOMAL CYTOCHROME-P-450 AND THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID	218	218
284	14	9191 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(18):13092-13099 SUTTER TR; TANG YM; HAYES CL; WO YYP; JABS EW; LI X; YIN H; CODY CW; GREENLEE WF COMPLETE CDNA SEQUENCE OF A HUMAN DIOXIN-INDUCIBLE MESSENGER- RNA IDENTIFIES A NEW GENE SUBFAMILY OF CYTOCHROME-P450 THAT MAPS TO CHROMOSOME-2	218	60
285	16	4498 1982 ANNUAL REVIEW OF BIOCHEMISTRY 51():21-59 MALMSTROM BG ENZYMOLOGY OF OXYGEN	217	2
286	4	5723 1986 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83(13):4715-4719 JOHN ME; JOHN MC; BOGGARAM V; SIMPSON ER; WATERMAN MR TRANSCRIPTIONAL REGULATION OF STEROID HYDROXYLASE GENES BY CORTICOTROPIN	217	70
287	11	2168 1973 CHEMICAL REVIEWS 73(4):365-384 NICOLIS G; PORTNOW J CHEMICAL OSCILLATIONS	216	2
288	5	4996 1983 STRUCTURE AND BONDING 54():93-124 CONNETT PH; WETTERHAHN KE METABOLISM OF THE CARCINOGEN CHROMATE BY CELLULAR-CONSTITUENTS	216	0
289	22	5884 1987 DRUG METABOLISM REVIEWS 18(4):441-515 HAWKINS JM; JONES WE; BONNER FW; GIBSON GG THE EFFECT OF PEROXISOME PROLIFERATORS ON MICROSOMAL, PEROXISOMAL, AND MITOCHONDRIAL ENZYME-ACTIVITIES IN THE LIVER AND KIDNEY	216	39
290	7	6743 1989 PHARMACOLOGY & THERAPEUTICS 43(1):53-76 WILKINSON GR; GUENGERICH FP; BRANCH RA GENETIC-POLYMORPHISM OF S-MEPHENYTOIN HYDROXYLATION	216	53
291	6	994 1969 BIOCHEMICAL JOURNAL 111(5):665-& TYLER DD EVIDENCE OF A PHOSPHATE-TRANSPORTER SYSTEM IN INNER MEMBRANE OF ISOLATED MITOCHONDRIA	215	11
292	12	2786 1975 DRUG METABOLISM AND DISPOSITION 3(4):245-253 BURKE MD; MAYER RT INHERENT SPECIFICITIES OF PURIFIED CYTOCHROMES P-450 AND P-448 TOWARD BIPHENYL HYDROXYLATION AND ETHOXYRESORUFIN DE-ETHYLATION	215	77
293	5	2873 1975 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 97(5):1032-1045 MAYERLE JJ; DENMARK SE; DEPAMPHILIS BV; IBERS JA; HOLM RH SYNTHETIC ANALOGS OF ACTIVE-SITES OF IRON-SULFUR PROTEINS .11. SYNTHESIS AND PROPERTIES OF COMPLEXES CONTAINING FE2S2 CORE AND STRUCTURES OF BIS[ORTHO-XYLYL-ALPHA,ALPHA'-DITHIOLATO-MU- SULFIDO-FERRATE(III)]AND BIS[PARA-TOLYLTHIOLATO-MU-SULFIDO- FERRATE(III)] DIANIONS	215	3
294	39	3939 1979 PHARMACOLOGY & THERAPEUTICS 6(1):99-121 GUENGERICH FP ISOLATION AND PURIFICATION OF CYTOCHROME-P-450, AND THE EXISTENCE OF MULTIPLE FORMS	215	42
295	10	5746 1987 ACCOUNTS OF CHEMICAL RESEARCH 20(8):289-294 DEMONTELLANO PRO CONTROL OF THE CATALYTIC ACTIVITY OF PROSTHETIC HEME BY THE STRUCTURE OF HEMOPROTEINS	215	17
296	8	1752 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 152(2):457-& LU AYH; WEST S; SOMOGYI A; CONNEY AH; KUNTZMAN R PREGNENOLONE-16ALPHA-CARBONITRILE - NEW TYPE OF INDUCER OF DRUG-METABOLIZING ENZYMES	214	63
297	9	2030 1973 ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 37():135-187 SCHIMKE RT CONTROL OF ENZYME LEVELS IN MAMMALIAN TISSUES	214	4
298	2	281 1964 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 14(4):329-& ORRENIUS S; DALLNER G; ERNSTER L INHIBITION OF TPNH-LINKED LIPID PEROXIDATION OF LIVER MICROSOMES BY DRUGS UNDERGOING OXIDATIVE DEMETHYLATION	213	74
299	3	5025 1984 ANNUAL REVIEW OF BIOCHEMISTRY 53():493-535 WALSH CT SUICIDE SUBSTRATES, MECHANISM BASED ENZYME INACTIVATORS - RECENT DEVELOPMENTS	213	3
300	3	5166 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(20):2339-2345 RADMARK O; SHIMIZU T; JORNVALL H; SAMUELSSON B LEUKOTRIENE-A-4 HYDROLASE IN HUMAN-LEUKOCYTES - PURIFICATION AND PROPERTIES	211	0

#	Cited nodes	Nodes / Authors	GCS	LCS
301	5	6135 1988 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 26(4):363-372 SESARDIC D; BOOBIS AR; EDWARDS RJ; DAVIES DS A FORM OF CYTOCHROME-P450 IN MAN, ORTHOLOGOUS TO FORM D IN THE RAT, CATALYZES THE O-DEETHYLATION OF PHENACETIN AND IS INDUCIBLE BY CIGARETTE-SMOKING	211	98
302	8	6651 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(32):19385-19391 MEANS GD; MAHENDROO MS; CORBIN CJ; MATHIS JM; POWELL FE; MENDELSON CR; SIMPSON ER STRUCTURAL-ANALYSIS OF THE GENE ENCODING HUMAN AROMATASE CYTOCHROME-P-450, THE ENZYME RESPONSIBLE FOR ESTROGEN BIOSYNTHESIS	210	60
303	6	6631 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(6):3568-3572 SONG BJ; VEECH RL; PARK SS; GELBOIN HV; GONZALEZ FJ INDUCTION OF RAT HEPATIC N-NITROSODIMETHYLAMINE DEMETHYLASE BY ACETONE IS DUE TO PROTEIN STABILIZATION	209	84
304	13	11375 1998 PHARMACOTHERAPY 18(1):84-112 Michalets EL Update: Clinically significant cytochrome P-450 drug interactions	209	21
305	17	3363 1977 GASTROENTEROLOGY 72(6):1232-1239 GUZELIAN PS; BISSELL DM; MEYER UA DRUG-METABOLISM IN ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER- CULTURE	207	18
306	18	3975 1979 XENOBIOTICA 9(9):555-564 RENDIC S; SUNJIC V; TOSO R; KAJFEZ F; RUF HH INTERACTION OF CIMETIDINE WITH LIVER-MICROSOMES	207	23
307	12	8005 1992 CARCINOGENESIS 13(10):1789-1794 YAMAZAKI H; INUI Y; YUN CH; GUENGERICH FP; SHIMADA T CYTOCHROME P450 2E1 AND 2A6 ENZYMES AS MAJOR CATALYSTS FOR METABOLIC-ACTIVATION OF N-NITROSODIALKYLAMINES AND TOBACCO- RELATED NITROSAMINES IN HUMAN LIVER-MICROSOMES	207	60
308	2	158 1962 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 8(5):361-& CAIN DF; DAVIES RE BREAKDOWN OF ADENOSINE TRIPHOSPHATE DURING A SINGLE CONTRACTION OF WORKING MUSCLE	206	7
309	4	6537 1989 CLINICAL PHARMACOLOGY & THERAPEUTICS 46(5):521-527 BARGETZI MJ; AOYAMA T; GONZALEZ FJ; MEYER UA LIDOCAINE METABOLISM IN HUMAN-LIVER MICROSOMES BY CYTOCHROME- P450IIIA4	206	55
310	58	7007 1990 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 25(2):97-153 GUENGERICH FP ENZYMATIC OXIDATION OF XENOBIOTIC CHEMICALS	206	63
311	20	8104 1992 FASEB JOURNAL 6(2):731-736 CAPDEVILA JH; FALCK JR; ESTABROOK RW CYTOCHROME-P450 AND THE ARACHIDONATE CASCADE	206	206
312	12	8412 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 306(1):240-245 WRIGHTON SA; STEVENS JC; BECKER GW; VANDENBRANDEN M ISOLATION AND CHARACTERIZATION OF HUMAN LIVER CYTOCHROME-P450 2C19 - CORRELATION BETWEEN 2C19 AND S-MEPHENYTOIN-4'- HYDROXYLATION	206	55
313	6	1776 1972 BIOCHEMICAL GENETICS 6(2-3):157-& THOMAS PE; KOURI RE; HUTTON JJ GENETICS OF ARYL HYDROCARBON HYDROXYLASE INDUCTION IN MICE - SINGLE GENE DIFFERENCE BETWEEN C57BL/6J AND DBA/2J	205	30
314	4	468 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 22(6):620-& IMAI Y; SATO R SUBSTRATE INTERACTION WITH HYDROXYLASE SYSTEM IN LIVER MICROSOMES	204	187
315	12	3872 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(21):1015-1023 NEGISHI M; NEBERT DW STRUCTURAL GENE-PRODUCTS OF THE AH-LOCUS - GENETIC AND IMMUNOCHEMICAL EVIDENCE FOR 2 FORMS OF MOUSE-LIVER CYTOCHROME- P-450 INDUCED BY 3-METHYLCHOLANTHRENE	204	0
316	21	5122 1984 EUROPEAN JOURNAL OF BIOCHEMISTRY 139(2):235-246 TAMBURINI PP; MASSON HA; BAINS SK; MAKOWSKI RJ; MORRIS B; GIBSON GG MULTIPLE FORMS OF HEPATIC CYTOCHROME-P-450 - PURIFICATION, CHARACTERIZATION AND COMPARISON OF A NOVEL CLOFIBRATE-INDUCED ISOZYME WITH OTHER MAJOR FORMS OF CYTOCHROME-P-450	204	88
317	10	7202 1990 JOURNAL OF THE NATIONAL CANCER INSTITUTE 82(16):1333-1339 MCLEMORE TL; ADELBERG S; LIU MC; MCMAHON NA; YU SJ; HUBBARD WC; CZERWINSKI M; WOOD TG; STORENG R; LUBET RA; EGGLESTON JC; BOYD MR; HINES RN EXPRESSION OF CYP1A1 GENE IN PATIENTS WITH LUNG-CANCER - EVIDENCE FOR CIGARETTE SMOKE-INDUCED GENE-EXPRESSION IN NORMAL LUNG-TISSUE AND FOR ALTERED GENE-REGULATION IN PRIMARY PULMONARY CARCINOMAS	204	54
318	19	7734 1991 MOLECULAR PHARMACOLOGY 40(5):679-685 YUN CH; SHIMADA T; GUENGERICH FP PURIFICATION AND CHARACTERIZATION OF HUMAN LIVER MICROSOMAL CYTOCHROME-P-450 2A6	202	89
319	10	7528 1991 DNA AND CELL BIOLOGY 10(8):545-558 BROLY F; GAEDIGK A; HEIM M; EICHELBAUM M; MORIKE K; MEYER UA DEBRISOQUINE SPARTEINE HYDROXYLATION GENOTYPE AND PHENOTYPE - ANALYSIS OF COMMON MUTATIONS AND ALLELES OF CYP2D6 IN A EUROPEAN POPULATION	201	30
320	3	6357 1989 ANNALS OF HUMAN GENETICS 53():89-140 SEARLE AG; PETERS J; LYON MF; HALL JG; EVANS EP; EDWARDS JH; BUCKLE VJ CHROMOSOME MAPS OF MAN AND MOUSE .4.	200	2
321	29	6990 1990 CHEMICAL RESEARCH IN TOXICOLOGY 3(4):363-371 GUENGERICH FP MECHANISM-BASED INACTIVATION OF HUMAN LIVER MICROSOMAL CYTOCHROME-P-450-IIIA4 BY GESTODENE	200	78
322	8	7180 1990 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 252(1):442-447 RELLING MV; AOYAMA T; GONZALEZ FJ; MEYER UA TOLBUTAMIDE AND MEPHENYTOIN HYDROXYLATION BY HUMAN CYTOCHROME- P450S IN THE CYP2C SUBFAMILY	200	73
323	6	9051 1994 CHEMICAL REVIEWS 94(2):373-431 KIPLINGER JL; RICHMOND TG; OSTERBERG CE ACTIVATION OF CARBON FLUORINE BONDS BY METAL-COMPLEXES	200	0
324	4	374 1965 BIOCHEMISCHE ZEITSCHRIFT 341(4):357-& CHANCE B; WILLIAMS.JR; JAMIESON D; SCHOENER B PROPERTIES AND KINETICS OF REDUCED PYRIDINE NUCLEOTIDE FLUORESCENCE OF ISOLATED AND IN VIVO RAT HEART	199	25
325	19	2134 1973 BIOCHIMICA ET BIOPHYSICA ACTA 301(2):129-154 SLATER EC MECHANISM OF ACTION OF RESPIRATORY INHIBITOR, ANTIMYCIN	199	12
326	31	3239 1977 ANNUAL REVIEW OF BIOCHEMISTRY 46():765-795 LIN ECC GLYCEROL UTILIZATION AND ITS REGULATION IN MAMMALS	199	2
327	48	3541 1978 BIOCHIMICA ET BIOPHYSICA ACTA 473(3-4):149-186 DEPIERRE JW; ERNSTER L METABOLISM OF POLYCYCLIC-HYDROCARBONS AND ITS RELATIONSHIP TO CANCER	199	24
328	33	9325 1994 PHARMACOGENETICS 4(4):171-184 WATKINS PB NONINVASIVE TESTS OF CYP3A ENZYMES	199	44
329	6	1011 1969 BIOCHEMISTRY 8(1):322-& CRIDDLE RS; SCHATZ G PROMITOCHONDRIA OF ANAEROBICALLY GROWN YEAST .I. ISOLATION AND BIOCHEMICAL PROPERTIES	197	15
330	6	6754 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(20):7823-7827 IMAI M; SHIMADA H; WATANABE Y; MATSUSHIMAHIBIYA Y; MAKINO R; KOGA H; HORIUCHI T; ISHIMURA Y UNCOUPLING OF THE CYTOCHROME P-450CAM MONOOXYGENASE REACTION BY A SINGLE MUTATION, THREONINE-252 TO ALANINE OR VALINE - A POSSIBLE ROLE OF THE HYDROXY AMINO-ACID IN OXYGEN ACTIVATION	197	77
331	14	1457 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 147(1):14-& HRYCAY EG; OBRIEN PJ CYTOCHROME P-450 AS A MICROSOMAL PEROXIDASE UTILIZING A LIPID PEROXIDE SUBSTRATE	196	66
332	3	1464 1971 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42(1):132-& ESTABROOK RW; HILDEBRANDT AG; BARON J; NETTER KJ; LEIBMAN K NEW SPECTRAL INTERMEDIATE ASSOCIATED WITH CYTOCHROME-P-450 FUNCTION IN LIVER MICROSOMES	196	196
333	18	7677 1991 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 256(3):1189-1194 GUENGERICH FP; TURVY CG COMPARISON OF LEVELS OF SEVERAL HUMAN MICROSOMAL CYTOCHROME-P- 450 ENZYMES AND EPOXIDE HYDROLASE IN NORMAL AND DISEASE STATES USING IMMUNOCHEMICAL ANALYSIS OF SURGICAL LIVER SAMPLES	196	62
334	14	7842 1992 ANNUAL REVIEW OF MICROBIOLOGY 46():565-601 HARAYAMA S; KOK M; NEIDLE EL FUNCTIONAL AND EVOLUTIONARY RELATIONSHIPS AMONG DIVERSE OXYGENASES	196	5
335	2	667 1967 EUROPEAN JOURNAL OF BIOCHEMISTRY 2(3):275-& SIMPSON ER; BOYD GS CHOLESTEROL SIDE-CHAIN CLEAVAGE SYSTEM OF BOVINE ADRENAL CORTEX	195	91
336	17	1186 1970 AMERICAN JOURNAL OF MEDICINE 49(5):617-& REMMER H ROLE OF LIVER IN DRUG METABOLISM	195	23
337	7	4257 1981 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 210(2):505-516 JONES DP; EKLOW L; THOR H; ORRENIUS S METABOLISM OF HYDROGEN-PEROXIDE IN ISOLATED HEPATOCYTES - RELATIVE CONTRIBUTIONS OF CATALASE AND GLUTATHIONE-PEROXIDASE IN DECOMPOSITION OF ENDOGENOUSLY GENERATED H2O2	195	15
338	5	5437 1985 JOURNAL OF BIOLOGICAL CHEMISTRY 260(12):7435-7441 GONZALEZ FJ; NEBERT DW; HARDWICK JP; KASPER CB COMPLETE CDNA AND PROTEIN-SEQUENCE OF A PREGNENOLONE 16-ALPHA- CARBONITRILE-INDUCED CYTOCHROME-P-450 - A REPRESENTATIVE OF A NEW GENE FAMILY	195	108
339	28	8920 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 311(2):437-442 CHANG TKH; GONZALEZ FJ; WAXMAN DJ EVALUATION OF TRIACETYLOLEANDOMYCIN, ALPHA-NAPHTHOFLAVONE AND DIETHYLDITHIOCARBAMATE AS SELECTIVE CHEMICAL PROBES FOR INHIBITION OF HUMAN CYTOCHROMES P450	195	46
340	1	1691 1971 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68(1):16-& MALKIN R; BEARDEN AJ PRIMARY REACTIONS OF PHOTOSYNTHESIS - PHOTOREDUCTION OF A BOUND CHLOROPLAST FERREDOXIN AT LOW TEMPERATURE AS DETECTED BY EPR SPECTROSCOPY	194	1
341	39	6919 1990 BIOCHEMISTRY 29(51):11280-11292 BRIAN WR; SARI MA; IWASAKI M; SHIMADA T; KAMINSKY LS; GUENGERICH FP CATALYTIC ACTIVITIES OF HUMAN LIVER CYTOCHROME-P-450-IIIA4 EXPRESSED IN SACCHAROMYCES-CEREVISIAE	194	104
342	10	8297 1992 PHARMACOLOGY & THERAPEUTICS 53(1):127-166 FRENKEL K CARCINOGEN-MEDIATED OXIDANT FORMATION AND OXIDATIVE DNA DAMAGE	194	1
343	23	8975 1994 BIOCHEMICAL PHARMACOLOGY 48(5):923-936 BURKE MD; THOMPSON S; WEAVER RJ; WOLF CR; MAYER RT CYTOCHROME-P450 SPECIFICITIES OF ALKOXYRESORUFIN O-DEALKYLATION IN HUMAN AND RAT-LIVER	194	54
344	27	11483 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):11-23 Waxman DJ P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR	194	46
345	3	1612 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(2):475-& MAITRA PK; LOBO Z KINETIC STUDY OF GLYCOLYTIC ENZYME SYNTHESIS IN YEAST	193	7
346	8	12239 2000 SCIENCE 287(5458):1615-1622 Schlichting I; Berendzen J; Chu K; Stock AM; Maves SA; Benson DE; Sweet BM; Ringe D; Petsko GA; Sligar SG The catalytic pathway of cytochrome P450cam at atomic resolution	193	15
347	9	354 1965 ANNUAL REVIEW OF BIOCHEMISTRY 34():595-& MASON HS OXIDASES	192	34
348	7	712 1967 MOLECULAR PHARMACOLOGY 3(6):516-& SCHENKMAN JB; FREY I; REMMER H; ESTABROOK RW SEX DIFFERENCES IN DRUG METABOLISM BY RAT LIVER MICROSOMES	192	193
349	1	1453 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 145(1):255-& PATRIARC.P; CRAMER R; MONCALVO S; ROSSI F; ROMEO D ENZYMATIC BASIS OF METABOLIC STIMULATION IN LEUCOCYTES DURING PHAGOCYTOSIS - ROLE OF ACTIVATED NADPH OXIDASE	192	0
350	6	1735 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 149(2):369-& OSHINO N; SATO R DIETARY CONTROL OF MICROSOMAL STEARYL COA DESATURATION ENZYME- SYSTEM IN RAT-LIVER	192	15
351	23	1981 1972 MOLECULAR PHARMACOLOGY 8(6):667-& GOUJON FM; GIELEN JE; NEBERT DW GENETIC EXPRESSION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION .4. INTERACTION OF VARIOUS COMPOUNDS WITH DIFFERENT FORMS OF CYTOCHROME-P-450 AND EFFECT ON BENZO[A]PYRENE METABOLISM IN- VITRO	192	51
352	15	5178 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(10):6447-6458 INGELMANSUNDBERG M; JOHANSSON I MECHANISMS OF HYDROXYL RADICAL FORMATION AND ETHANOL OXIDATION BY ETHANOL-INDUCIBLE AND OTHER FORMS OF RABBIT LIVER MICROSOMAL CYTOCHROMES-P-450	192	0
353	6	6953 1990 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 29(6):651-663 SESARDIC D; BOOBIS AR; MURRAY BP; MURRAY S; SEGURA J; DELATORRE R; DAVIES DS FURAFYLLINE IS A POTENT AND SELECTIVE INHIBITOR OF CYTOCHROME- P450IA2 IN MAN	192	55
354	16	3130 1976 JOURNAL OF BIOLOGICAL CHEMISTRY 251(13):4010-4016 PETERSON JA; EBEL RE; OKEEFFE DH; MATSUBARA T; ESTABROOK RW TEMPERATURE-DEPENDENCE OF CYTOCHROME-P-450 REDUCTION - MODEL FOR NADPH-CYTOCHROME P-450 REDUCTASE - CYTOCHROME-P-450 INTERACTION	191	191
355	4	6177 1988 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 7(6):379-387 HEILMANN LJ; SHEEN YY; BIGELOW SW; NEBERT DW TROUT-P450IA1 - CDNA AND DEDUCED PROTEIN-SEQUENCE, EXPRESSION IN LIVER, AND EVOLUTIONARY SIGNIFICANCE	191	88
356	37	9878 1995 STRUCTURE 3(1):41-62 HASEMANN CA; KURUMBAIL RG; BODDUPALLI SS; PETERSON JA; DEISENHOFER J STRUCTURE AND FUNCTION OF CYTOCHROMES-P450 - A COMPARATIVE- ANALYSIS OF 3 CRYSTAL-STRUCTURES	191	82
357	8	1053 1969 CANCER RESEARCH 29(10):1763-& NEBERT DW; WINKER J; GELBOIN HV ARYL HYDROCARBON HYDROXYLASE ACTIVITY IN HUMAN PLACENTA FROM CIGARETTE SMOKING AND NONSMOKING WOMEN	190	22
358	7	1443 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 143(1):318-& FRANKLIN MR; ESTABROOK RW INHIBITORY ACTION OF MERSALYL ON MICROSOMAL DRUG OXIDATION - RIGID ORGANIZATION OF ELECTRON TRANSPORT CHAIN	190	190
359	7	3026 1976 BIOLOGY OF REPRODUCTION 14(1):30-53 MARSH JM ROLE OF CYCLIC-AMP IN GONADAL STEROIDOGENESIS	190	3
360	5	5873 1987 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 6(5):439-448 PICADOLEONARD J; MILLER WL CLONING AND SEQUENCE OF THE HUMAN-GENE FOR P450C17 (STEROID 17- ALPHA-HYDROXYLASE/17,20 LYASE) - SIMILARITY WITH THE GENE FOR P450C21	189	61
361	4	1620 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(10):3342-& PEISACH J; BLUMBERG WE; OGAWA S; RACHMILE.EA; OLTZIK R EFFECTS OF PROTEIN CONFORMATION ON HEME SYMMETRY IN HIGH SPIN FERRIC HEME PROTEINS AS STUDIED BY ELECTRON PARAMAGNETIC RESONANCE	188	10
362	32	5867 1987 CRC CRITICAL REVIEWS IN TOXICOLOGY 18(1):27-79 HORTON AA; FAIRHURST S LIPID-PEROXIDATION AND MECHANISMS OF TOXICITY	188	3
363	30	8407 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 305(1):123-131 GILLAM EMJ; BABA T; KIM BR; OHMORI S; GUENGERICH FP EXPRESSION OF MODIFIED HUMAN CYTOCHROME-P450 3A4 IN ESCHERICHIA-COLI AND PURIFICATION AND RECONSTITUTION OF THE ENZYME	188	110
364	6	11387 1998 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95(12):6965-6970 Fisher CR; Graves KH; Parlow AF; Simpson ER Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene	188	8
365	10	4533 1982 BIOCHEMICAL PHARMACOLOGY 31(6):907-913 LILIENBLUM W; WALLI AK; BOCK KW DIFFERENTIAL INDUCTION OF RAT-LIVER MICROSOMAL UDP- GLUCURONOSYLTRANSFERASE ACTIVITIES BY VARIOUS INDUCING AGENTS	187	10
366	18	7369 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 290(1):160-166 WAXMAN DJ; LAPENSON DP; AOYAMA T; GELBOIN HV; GONZALEZ FJ; KORZEKWA K STEROID-HORMONE HYDROXYLASE SPECIFICITIES OF 11 CDNA-EXPRESSED HUMAN CYTOCHROME-P450S	187	81
367	33	1873 1972 DRUG METABOLISM REVIEWS 1(2):153-227 WILKINSO.CF; BRATTSTE.LB MICROSOMAL DRUG-METABOLIZING ENZYMES IN INSECTS	186	0
368	4	5706 1986 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 108(23):7281-7286 COOK BR; REINERT TJ; SUSLICK KS SHAPE SELECTIVE ALKANE HYDROXYLATION BY METALLOPORPHYRIN CATALYSTS	186	6
369	4	7767 1991 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88(21):9543-9547 BJELDANES LF; KIM JY; GROSE KR; BARTHOLOMEW JC; BRADFIELD CA AROMATIC HYDROCARBON RESPONSIVENESS-RECEPTOR AGONISTS GENERATED FROM INDOLE-3-CARBINOL INVITRO AND INVIVO - COMPARISONS WITH 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN	186	12
370	15	8732 1993 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 265(1):401-407 TASSANEEYAKUL W; BIRKETT DJ; VERONESE ME; MCMANUS ME; TUKEY RH; QUATTROCHI LC; GELBOIN HV; MINERS JO SPECIFICITY OF SUBSTRATE AND INHIBITOR PROBES FOR HUMAN CYTOCHROMES-P450 1A1 AND 1A2	186	45
371	6	787 1968 BIOCHEMICAL JOURNAL 110(3):407-& HOLTZMAN JL; GRAM TE; GIGON PL; GILLETTE JR DISTRIBUTION OF COMPONENTS OF MIXED-FUNCTION OXIDASE BETWEEN ROUGH AND SMOOTH ENDOPLASMIC RETICULUM OF LIVER CELLS	185	82
372	5	6283 1988 MOLECULAR PHARMACOLOGY 33(5):500-508 GUENGERICH FP OXIDATION OF 17 ALPHA-ETHYNYLESTRADIOL BY HUMAN-LIVER CYTOCHROME-P-450	185	78
373	55	9368 1994 TOXICOLOGY AND APPLIED PHARMACOLOGY 125(2):163-175 HALPERT JR; GUENGERICH FP; BEND JR; CORREIA MA SELECTIVE INHIBITORS OF CYTOCHROMES P450	185	55
374	2	150 1962 AMERICAN JOURNAL OF MEDICINE 33(3):319-& LIEBER CS; DAVIDSON CS SOME METABOLIC EFFECTS OF ETHYL ALCOHOL	184	13
375	8	2601 1974 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 4(3):299-312 WILKINSO.CF; HETNARSK.K; HICKS LJ SUBSTITUTED IMIDAZOLES AS INHIBITORS OF MICROSOMAL OXIDATION AND INSECTICIDE SYNERGISTS	184	0
376	2	4981 1983 PHOTOCHEMISTRY AND PHOTOBIOLOGY 37(6):679-690 RABINOWITCH HD; FRIDOVICH I SUPEROXIDE RADICALS, SUPEROXIDE DISMUTASES AND OXYGEN-TOXICITY IN PLANTS	184	1
377	2	5842 1987 CANCER RESEARCH 47(16):4271-4277 KENSLER TW; EGNER PA; DOLAN PM; GROOPMAN JD; ROEBUCK BD MECHANISM OF PROTECTION AGAINST AFLATOXIN TUMORIGENICITY IN RATS FED 5-(2-PYRAZINYL)-4-METHYL-1,2-DITHIOL-3-THIONE (OLTIPRAZ) AND RELATED 1,2-DITHIOL-3-THIONES AND 1,2-DITHIOL-3- ONES	184	11
378	5	6822 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 276(2):424-432 NIZNIK HB; TYNDALE RF; SALLEE FR; GONZALEZ FJ; HARDWICK JP; INABA T; KALOW W THE DOPAMINE TRANSPORTER AND CYTOCHROME-P450IID1 (DEBRISOQUINE 4-HYDROXYLASE) IN BRAIN - RESOLUTION AND IDENTIFICATION OF 2 DISTINCT [H-3] GBR-12935 BINDING-PROTEINS	184	22
379	4	9205 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(43):26669-26676 GARVEY EP; OPLINGER JA; TANOURY GJ; SHERMAN PA; FOWLER M; MARSHALL S; HARMON MF; PAITH JE; FURFINE ES POTENT AND SELECTIVE-INHIBITION OF HUMAN NITRIC-OXIDE SYNTHASES - INHIBITION BY NON-AMINO ACID ISOTHIOUREAS	184	1
380	8	2967 1976 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 176(1):91-102 BISSELL DM; HAMMAKER LE CYTOCHROME-P-450 HEME AND REGULATION OF HEPATIC HEME OXYGENASE ACTIVITY	182	27
381	19	2846 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(6):2157-2163 RYAN D; LU AYH; WEST S; LEVIN W MULTIPLE FORMS OF CYTOCHROME-P-450 IN PHENOBARBITAL-TREATED RATS AND 3-METHYLCHOLANTHRENE-TREATED RATS - SEPARATION AND SPECTRAL PROPERTIES	181	72
382	16	3132 1976 JOURNAL OF BIOLOGICAL CHEMISTRY 251(15):4659-4665 HUANG MT; WEST SB; LU AYH SEPARATION, PURIFICATION, AND PROPERTIES OF MULTIPLE FORMS OF CYTOCHROME-P-450 FROM LIVER-MICROSOMES OF PHENOBARBITAL-TREATED MICE	181	54
383	4	3476 1978 ANALYTICAL BIOCHEMISTRY 86(2):725-732 JOHANNESEN KAM; DEPIERRE JW MEASUREMENT OF CYTOCHROME-P-450 IN PRESENCE OF LARGE AMOUNTS OF CONTAMINATING HEMOGLOBIN AND METHEMOGLOBIN	181	34
384	6	4039 1980 BIOCHEMICAL PHARMACOLOGY 29(22):3075-3080 PELKONEN O; PUURUNEN J THE EFFECT OF CIMETIDINE ON INVITRO AND INVIVO MICROSOMAL DRUG- METABOLISM IN THE RAT	181	26
385	7	4831 1983 CANCER RESEARCH 43(2):623-629 TU YY; YANG CS HIGH-AFFINITY NITROSAMINE DEALKYLASE SYSTEM IN RAT-LIVER MICROSOMES AND ITS INDUCTION BY FASTING	181	51
386	6	5121 1984 EUROPEAN JOURNAL OF BIOCHEMISTRY 138(3):459-463 EKLOW L; MOLDEUS P; ORRENIUS S OXIDATION OF GLUTATHIONE DURING HYDROPEROXIDE METABOLISM - A STUDY USING ISOLATED HEPATOCYTES AND THE GLUTATHIONE-REDUCTASE INHIBITOR 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA	181	10
387	12	5851 1987 CHEMICA SCRIPTA 27A():1-13 ERNSTER L DT-DIAPHORASE - A HISTORICAL REVIEW	181	0
388	84	10867 1997 PHYSIOLOGICAL REVIEWS 77(2):517-544 Lieber CS Cytochrome P-4502E1: Its physiological and pathological role	181	22
389	26	2057 1973 ANNUAL REVIEW OF BIOCHEMISTRY 42():159-204 ORMEJOHN.WH IRON-SULFUR PROTEINS - STRUCTURE AND FUNCTION	180	0
390	13	9644 1995 ENDOCRINE REVIEWS 16(3):322-353 EHRMANN DA; BARNES RB; ROSENFIELD RL POLYCYSTIC-OVARY-SYNDROME AS A FORM OF FUNCTIONAL OVARIAN HYPERANDROGENISM DUE TO DYSREGULATION OF ANDROGEN SECRETION	180	7
391	4	2440 1974 BIOCHEMICAL PHARMACOLOGY 23(17):2377-2386 WILKINSO.CF; HETNARSK.K; CANTWELL GP; DICARLO FJ STRUCTURE-ACTIVITY-RELATIONSHIPS IN EFFECTS OF 1- ALKYLIMIDAZOLES ON MICROSOMAL OXIDATION INVITRO AND INVIVO	179	0
392	20	4379 1981 JOURNAL OF BIOLOGICAL CHEMISTRY 256(1):266-277 VERMILION JL; BALLOU DP; MASSEY V; COON MJ SEPARATE ROLES FOR FMN AND FAD IN CATALYSIS BY LIVER MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE	179	60
393	11	6998 1990 CLINICAL PHARMACOKINETICS 18(3):220-239 BROSEN K RECENT DEVELOPMENTS IN HEPATIC DRUG OXIDATION - IMPLICATIONS FOR CLINICAL PHARMACOKINETICS	179	50
394	5	740 1968 AMERICAN JOURNAL OF CARDIOLOGY 22(3):349-& WOLLENBE.A; KRAUSE EG METABOLIC CONTROL CHARACTERISTICS OF ACUTELY ISCHEMIC MYOCARDIUM	177	0
395	5	938 1968 RESPIRATION PHYSIOLOGY 4(3):292-& JOBSIS FF; STAINSBY WN OXIDATION OF NADH DURING CONTRACTIONS OF CIRCULATED MAMMALIAN SKELETAL MUSCLE	177	6
396	13	1252 1970 BIOCHEMISTRY 9(10):2081-& SCHENKMAN JB STUDIES ON NATURE OF TYPE-I AND TYPE-II SPECTRAL CHANGES IN LIVER MICROSOMES	177	130
397	9	1689 1971 PLANT PHYSIOLOGY 47(2):236-& BENDALL DS; BONNER WD CYANIDE-INSENSITIVE RESPIRATION IN PLANT MITOCHONDRIA	177	9
398	2	9853 1995 PLANT CELL 7(7):1071-1083 HOLTON TA; CORNISH EC GENETICS AND BIOCHEMISTRY OF ANTHOCYANIN BIOSYNTHESIS	177	5
399	4	484 1966 BIOCHEMISTRY 5(7):2326-& COCKRELL RS; HARRIS EJ; PRESSMAN BC ENERGETICS OF POTASSIUM TRANSPORT IN MITOCHONDRIA INDUCED BY VALINOMYCIN	176	16
400	2	525 1966 JOURNAL OF BIOCHEMISTRY 59(5):501-& OZAWA K; SETA K; TAKEDA H; ANDO K; HANDA H; ARAKI C ON ISOLATION OF MITOCHONDRIA WITH HIGH RESPIRATORY CONTROL FROM RAT BRAIN	176	7

#	Cited nodes	Nodes / Authors	GCS	LCS
401	21	1385 1970 MOLECULAR PHARMACOLOGY 6(3):213-& LU AYH; STROBEL HW; COON MJ PROPERTIES OF A SOLUBILIZED FORM OF CYTOCHROME P-450-CONTAINING MIXED-FUNCTION OXIDASE OF LIVER MICROSOMES	176	81
402	4	3073 1976 ENDOCRINOLOGY 98(4):1031-1046 TAUROG A MECHANISM OF ACTION OF THIOUREYLENE ANTITHYROID DRUGS	176	13
403	7	3579 1978 COORDINATION CHEMISTRY REVIEWS 26(3):207-262 EATON SS; EATON GR METAL-NITROXYL INTERACTIONS .5. INTERACTION OF SPIN LABELS WITH TRANSITION-METALS	176	0
404	15	6512 1989 CANCER RESEARCH 49(22):6304-6312 SHIMADA T; MARTIN MV; PRUESSSCHWARTZ D; MARNETT LJ; GUENGERICH FP ROLES OF INDIVIDUAL HUMAN CYTOCHROME-P-450 ENZYMES IN THE BIOACTIVATION OF BENZO(A)PYRENE, 7,8-DIHYDROXY-7,8- DIHYDROBENZO(A)PYRENE, AND OTHER DIHYDRODIOL DERIVATIVES OF POLYCYCLIC AROMATIC-HYDROCARBONS	176	72
405	2	136 1961 JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY 9(1):19-& ESTABROOK R; HOLOWINS.A STUDIES ON CONTENT AND ORGANIZATION OF RESPIRATORY ENZYMES OF MITOCHONDRIA	175	0
406	7	666 1967 EUROPEAN JOURNAL OF BIOCHEMISTRY 1(4):419-& IMAI Y; SATO R CONVERSION OF P-450 TO P-420 BY NEUTRAL SALTS AND SOME OTHER REAGENTS	175	89
407	2	1649 1971 JOURNAL OF NEUROPHYSIOLOGY 34(5):735-& JOBSIS FF; OCONNOR M; VITALE A; VREMAN H INTRACELLULAR REDOX CHANGES IN FUNCTIONING CEREBRAL CORTEX .1. METABOLIC EFFECTS OF EPILEPTIFORM ACTIVITY	175	12
408	3	1822 1972 BIOCHIMICA ET BIOPHYSICA ACTA 263(2):272-& SUHARA K; TAKEMORI S; KATAGIRI M IMPROVED PURIFICATION OF BOVINE ADRENAL IRON-SULFUR PROTEIN	175	62
409	12	2553 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(10):3026-3033 GHAZARIA.JG; JEFCOATE CR; KNUTSON JC; ORMEJOHN.WH; DELUCA HF MITOCHONDRIAL CYTOCHROME P450 - COMPONENT OF CHICK KIDNEY 25- HYDROXYCHOLECALCIFEROL-1ALPHA-HYDROXYLASE	175	0
410	16	5179 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(11):6812-6817 GORSKY LD; KOOP DR; COON MJ ON THE STOICHIOMETRY OF THE OXIDASE AND MONOOXYGENASE REACTIONS CATALYZED BY LIVER MICROSOMAL CYTOCHROME-P-450 - PRODUCTS OF OXYGEN REDUCTION	175	65
411	7	7146 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(28):17209-17214 KAGIMOTO M; HEIM M; KAGIMOTO K; ZEUGIN T; MEYER UA MULTIPLE MUTATIONS OF THE HUMAN CYTOCHROME-P450IID6 GENE (CYP2D6) IN POOR METABOLIZERS OF DEBRISOQUINE - STUDY OF THE FUNCTIONAL-SIGNIFICANCE OF INDIVIDUAL MUTATIONS BY EXPRESSION OF CHIMERIC GENES	175	42
412	3	7315 1990 TRENDS IN PHARMACOLOGICAL SCIENCES 11(9):367-373 PIOMELLI D; GREENGARD P LIPOXYGENASE METABOLITES OF ARACHIDONIC-ACID IN NEURONAL TRANSMEMBRANE SIGNALING	175	5
413	24	9095 1994 DRUG METABOLISM AND DISPOSITION 22(6):947-955 LOWN KS; KOLARS JC; THUMMEL KE; BARNETT JL; KUNZE KL; WRIGHTON SA; WATKINS PB INTERPATIENT HETEROGENEITY IN EXPRESSION OF CYP3A4 AND CYP3A5 IN SMALL-BOWEL - LACK OF PREDICTION BY THE ERYTHROMYCIN BREATH TEST	175	31
414	6	1632 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(24):7826-& STROBEL HW; COON MJ EFFECT OF SUPEROXIDE GENERATION AND DISMUTATION ON HYDROXYLATION REACTIONS CATALYZED BY LIVER MICROSOMAL CYTOCHROME P-450	174	64
415	8	3025 1976 BIOCHIMICA ET BIOPHYSICA ACTA 456(2):129-148 HANSTEIN WG UNCOUPLING OF OXIDATIVE-PHOSPHORYLATION	174	2
416	7	4585 1982 CELL BIOLOGY INTERNATIONAL REPORTS 6(7):635-650 MCKEEHAN WL GLYCOLYSIS, GLUTAMINOLYSIS AND CELL-PROLIFERATION	174	1
417	1	10702 1997 FASEB JOURNAL 11(1):3-14 Weinshilboum RM; Otterness DM; Aksoy IA; Wood TC; Her C; Raftogianis RB Sulfotransferase molecular biology: cDNAs and genes	174	6
418	8	6030 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 261(2):257-263 CAPDEVILA J; GIL L; ORELLANA M; MARNETT LJ; MASON JI; YADAGIRI P; FALCK JR INHIBITORS OF CYTOCHROME P-450-DEPENDENT ARACHIDONIC-ACID METABOLISM	173	43
419	4	6307 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(21):8256-8260 ZANGER UM; HAURI HP; LOEPER J; HOMBERG JC; MEYER UA ANTIBODIES AGAINST HUMAN CYTOCHROME-P-450DB1 IN AUTOIMMUNE HEPATITIS TYPE-II	173	46
420	24	9329 1994 PHARMACOGENETICS 4(5):247-259 KOLARS JC; LOWN KS; SCHMIEDLINREN P; GHOSH M; FANG C; WRIGHTON SA; MERION RM; WATKINS PB CYP3A GENE-EXPRESSION IN HUMAN GUT EPITHELIUM	173	48
421	2	1568 1971 CHEMICO-BIOLOGICAL INTERACTIONS 3(5):383-& MATTOCKS AR; WHITE INH CONVERSION OF PYRROLIZIDINE ALKALOIDS TO N-OXIDES AND TO DIHYDROPYRROLIZINE DERIVATIVES BY RAT-LIVER MICROSOMES IN-VITRO	172	6
422	20	8058 1992 DRUG METABOLISM AND DISPOSITION 20(5):753-761 SATTLER M; GUENGERICH FP; YUN CH; CHRISTIANS U; SEWING KF CYTOCHROME-P-450 3A ENZYMES ARE RESPONSIBLE FOR BIOTRANSFORMATION OF FK506 AND RAPAMYCIN IN MAN AND RAT	172	18
423	1	69 1959 JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY 5(1):97-108 LEHNINGER AL; RAY BL; SCHNEIDER M THE SWELLING OF RAT LIVER MITOCHONDRIA BY THYROXINE AND ITS REVERSAL	170	6
424	13	1066 1969 EUROPEAN JOURNAL OF BIOCHEMISTRY 9(3):299-& ERNSTER L; LEE IY; NORLING B; PERSSON B STUDIES WITH UBIQUINONE-DEPLETED SUBMITOCHONDRIAL PARTICLES - ESSENTIALITY OF UBIQUINONE FOR INTERACTION OF SUCCINATE DEHYDROGENASE, NADH DEHYDROGENASE, AND CYTOCHROME B	170	18
425	4	1898 1972 GASTROENTEROLOGY 63(5):837-& GREIM H; TRULZSCH D; SCHAFFNE.F; DRESSLER K; CZYGAN P; POPPER H; ROBOZ J; HUTTERER F MECHANISM OF CHOLESTASIS .5. BILE-ACIDS IN NORMAL RAT LIVERS AND IN THOSE AFTER BILE-DUCT LIGATION	170	5
426	10	3641 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(24):8812-8819 VERMILION JL; COON MJ IDENTIFICATION OF THE HIGH AND LOW POTENTIAL FLAVINS OF LIVER MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE	170	55
427	21	3799 1979 BIOCHIMICA ET BIOPHYSICA ACTA 550(2):341-356 TANIGUCHI H; IMAI Y; IYANAGI T; SATO R INTERACTION BETWEEN NADPH-CYTOCHROME P-450 REDUCTASE AND CYTOCHROME-P-450 IN THE MEMBRANE OF PHOSPHATIDYLCHOLINE VESICLES	170	90
428	62	7036 1990 DRUG METABOLISM REVIEWS 22(1):1-85 IOANNIDES C; PARKE DV THE CYTOCHROME-P450-I GENE FAMILY OF MICROSOMAL HEMOPROTEINS AND THEIR ROLE IN THE METABOLIC-ACTIVATION OF CHEMICALS	170	50
429	3	7453 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1085(2):141-158 OSMUNDSEN H; BREMER J; PEDERSEN JI METABOLIC ASPECTS OF PEROXISOMAL BETA-OXIDATION	170	10
430	9	8991 1994 BIOCHEMISTRY 33(21):6450-6455 SHOU M; GROGAN J; MANCEWICZ JA; KRAUSZ KW; GONZALEZ FJ; GELBOIN HV; KORZEKWA KR ACTIVATION OF CYP3A4 - EVIDENCE FOR THE SIMULTANEOUS BINDING OF 2 SUBSTRATES IN A CYTOCHROME-P450 ACTIVE-SITE	170	62
431	4	40 1958 JOURNAL OF BIOLOGICAL CHEMISTRY 233(5):1223-1229 CHANCE B KINETICS AND INHIBITION OF CYTOCHROME COMPONENTS OF THE SUCCINIC OXIDASE SYSTEM .3. CYTOCHROME-B	169	62
432	20	1433 1971 ANNUAL REVIEW OF PHARMACOLOGY 11():37-& ANDERS MW ENHANCEMENT AND INHIBITION OF DRUG METABOLISM	169	60
433	13	2474 1974 CANCER RESEARCH 34(9):2196-2203 MATSUBARA T; PROUGH RA; BURKE MD; ESTABROOK RW PREPARATION OF MICROSOMAL FRACTIONS OF RODENT RESPIRATORY-TRACT AND THEIR CHARACTERIZATION	169	169
434	7	2868 1975 JOURNAL OF PHARMACY AND PHARMACOLOGY 27(10):739-746 IOANNIDES C; PARKE DV MECHANISM OF INDUCTION OF HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES BY A SERIES OF BARBITURATES	169	24
435	4	5858 1987 CHEMISTRY AND PHYSICS OF LIPIDS 44(2-4):191-208 MINOTTI G; AUST SD THE ROLE OF IRON IN THE INITIATION OF LIPID-PEROXIDATION	169	9
436	9	7550 1991 ENVIRONMENTAL HEALTH PERSPECTIVES 90():101-109 STEGEMAN JJ; LECH JJ CYTOCHROME-P-450 MONOOXYGENASE SYSTEMS IN AQUATIC SPECIES - CARCINOGEN METABOLISM AND BIOMARKERS FOR CARCINOGEN AND POLLUTANT EXPOSURE	169	24
437	18	11468 1999 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 39():103-125 Whitlock JP Induction of cytochrome P4501A1	169	14
438	8	1166 1969 PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 174(1036):315-& KUSHMERI.MJ; DAVIES RE CHEMICAL ENERGETICS OF MUSCLE CONTRACTION .2. CHEMISTRY, EFFICIENCY AND POWER OF MAXIMALLY WORKING SARTORIUS MUSCLES	168	0
439	2	1720 1972 ANALYTICA CHIMICA ACTA 61(3):329-& KORYTA J THEORY AND APPLICATIONS OF ION-SELECTIVE ELECTRODES	168	1
440	4	3148 1976 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 196(2):501-509 LAUTERBURG BH; BIRCHER J EXPIRATORY MEASUREMENT OF MAXIMAL AMINOPYRINE DEMETHYLATION INVIVO - EFFECT OF PHENOBARBITAL, PARTIAL-HEPATECTOMY, PORTACAVAL-SHUNT AND BILE-DUCT LIGATION IN RAT	168	6
441	4	4972 1983 MOLECULAR PHARMACOLOGY 24(1):146-155 KAMATAKI T; MAEDA K; YAMAZOE Y; MATSUDA N; ISHII K; KATO R A HIGH-SPIN FORM OF CYTOCHROME-P-450 HIGHLY PURIFIED FROM POLYCHLORINATED BIPHENYL-TREATED RATS - CATALYTIC CHARACTERIZATION AND IMMUNOCHEMICAL QUANTITATION IN LIVER- MICROSOMES	168	49
442	4	2869 1975 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 6(3-4):317-322 SIITERI PK; THOMPSON EA STUDIES OF HUMAN PLACENTAL AROMATASE	167	10
443	3	3837 1979 EUROPEAN JOURNAL OF BIOCHEMISTRY 94(1):99-107 WOJTCZAK L; NALECZ MJ SURFACE-CHARGE OF BIOLOGICAL-MEMBRANES AS A POSSIBLE REGULATOR OF MEMBRANE-BOUND ENZYMES	167	7
444	4	4327 1981 CANCER RESEARCH 41(1):120-124 GARRO AJ; SEITZ HK; LIEBER CS ENHANCEMENT OF DIMETHYLNITROSAMINE METABOLISM AND ACTIVATION TO A MUTAGEN FOLLOWING CHRONIC ETHANOL-CONSUMPTION	167	28
445	9	1399 1970 PHYSIOLOGICAL REVIEWS 50(3):376-& RABINOWI.M; SWIFT H MITOCHONDRIAL NUCLEIC ACIDS AND THEIR RELATION TO BIOGENESIS OF MITOCHONDRIA	166	0
446	11	4251 1981 ANNUAL REVIEW OF PHYSIOLOGY 43():163-188 SIMPSON ER; MACDONALD PC ENDOCRINE PHYSIOLOGY OF THE PLACENTA	166	7
447	2	4947 1983 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 105(12):3905-3913 HAGEN KS; WATSON AD; HOLM RH SYNTHETIC ROUTES TO FE2S2, FE3S4, FE4S4, AND FE6S9 CLUSTERS FROM THE COMMON PRECURSOR [FE(SC2H5)4]2- - STRUCTURES AND PROPERTIES OF [FE3S4(SR)4]3- AND [FE6S9(SC2H5)2]4-, EXAMPLES OF THE NEWEST TYPES OF FE-S-SR CLUSTERS	166	0
448	3	4984 1983 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80(11):3504-3507 SNYDER GD; CAPDEVILA J; CHACOS N; MANNA S; FALCK JR ACTION OF LUTEINIZING-HORMONE-RELEASING HORMONE - INVOLVEMENT OF NOVEL ARACHIDONIC-ACID METABOLITES	166	72
449	8	5975 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(22):8125-8129 SCHWARTZMAN ML; BALAZY M; MASFERRER J; ABRAHAM NG; MCGIFF JC; MURPHY RC 12(R)-HYDROXYICOSATETRAENOIC ACID - A CYTOCHROME-P450-DEPENDENT ARACHIDONATE METABOLITE THAT INHIBITS NA+,K+-ATPASE IN THE CORNEA	166	48
450	30	9793 1995 JOURNAL OF VASCULAR RESEARCH 32(2):79-92 HARDER DR; CAMPBELL WB; ROMAN RJ ROLE OF CYTOCHROME-P-450 ENZYMES AND METABOLITES OF ARACHIDONIC-ACID IN THE CONTROL OF VASCULAR TONE	166	45
451	1	42 1958 NATURE 182(4644):1190-1193 CHANCE B; HOLMES W; HIGGINS J; CONNELLY CM LOCALIZATION OF INTERACTION SITES IN MULTI-COMPONENT TRANSFER SYSTEMS - THEOREMS DERIVED FROM ANALOGUES	165	36
452	9	683 1967 JOURNAL OF BIOCHEMISTRY 62(2):239-& IMAI Y; SATO R STUDIES ON SUBSTRATE INTERACTIONS WITH P-450 IN DRUG HYDROXYLATION BY LIVER MICROSOMES	165	136
453	22	4730 1982 XENOBIOTICA 12(11):701-716 GUENGERICH FP; DANNAN GA; WRIGHT ST; MARTIN MV; KAMINSKY LS PURIFICATION AND CHARACTERIZATION OF MICROSOMAL CYTOCHROME-P- 450S	165	41
454	9	8696 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(26):19463-19470 MAHENDROO MS; MENDELSON CR; SIMPSON ER TISSUE-SPECIFIC AND HORMONALLY CONTROLLED ALTERNATIVE PROMOTERS REGULATE AROMATASE CYTOCHROME-P450 GENE-EXPRESSION IN HUMAN ADIPOSE-TISSUE	165	38
455	7	531 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(3):624-& SACKTOR B; WORMSERS.E REGULATION OF METABOLISM IN WORKING MUSCLE IN VIVO .I. CONCENTRATIONS OF SOME GLYCOLYTIC TRICARBOXYLIC ACID CYCLE AND AMINO ACID INTERMEDIATES IN INSECT FLIGHT MUSCLE DURING FLIGHT	163	15
456	6	1145 1969 MOLECULAR PHARMACOLOGY 5(2):186-& SLADEK NE; MANNERIN.GJ INDUCTION OF DRUG METABOLISM .2. QUALITATIVE DIFFERENCES IN MICROSOMAL N-DEMETHYLATING SYSTEMS STIMULATED BY POLYCYCLIC HYDROCARBONS AND BY PHENOBARBITAL	163	83
457	6	5949 1987 MOLECULAR ENDOCRINOLOGY 1(8):542-547 SONG BJ; MATSUNAGA T; HARDWICK JP; PARK SS; VEECH RL; YANG CS; GELBOIN HV; GONZALEZ FJ STABILIZATION OF CYTOCHROME-P450J MESSENGER-RIBONUCLEIC-ACID IN THE DIABETIC RAT	163	66
458	19	8271 1992 MOLECULAR PHARMACOLOGY 41(5):856-864 SHIMADA T; YUN CH; YAMAZAKI H; GAUTIER JC; BEAUNE PH; GUENGERICH FP CHARACTERIZATION OF HUMAN LUNG MICROSOMAL CYTOCHROME-P-450 1A1 AND ITS ROLE IN THE OXIDATION OF CHEMICAL CARCINOGENS	163	43
459	1	74 1959 PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 150(939):149-191 KEILIN D THE LEEUWENHOEK LECTURE - THE PROBLEM OF ANABIOSIS OR LATENT LIFE - HISTORY AND CURRENT CONCEPT	162	1
460	3	4700 1982 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79(3):767-770 CAPDEVILA J; MARNETT LJ; CHACOS N; PROUGH RA; ESTABROOK RW CYTOCHROME P-450-DEPENDENT OXYGENATION OF ARACHIDONIC-ACID TO HYDROXYICOSATETRAENOIC ACIDS	162	162
461	20	4802 1983 BIOCHEMISTRY 22(20):4846-4855 WAXMAN DJ; WALSH C CYTOCHROME-P-450 ISOZYME-1 FROM PHENOBARBITAL-INDUCED RAT-LIVER - PURIFICATION, CHARACTERIZATION, AND INTERACTIONS WITH METYRAPONE AND CYTOCHROME-B5	162	71
462	73	5750 1987 ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 60():35-87 BLACK SD; COON MJ P-450 CYTOCHROMES - STRUCTURE AND FUNCTION	162	85
463	7	5912 1987 JOURNAL OF BIOLOGICAL CHEMISTRY 262(4):1542-1551 ATOR MA; DEMONTELLANO PRO PROTEIN CONTROL OF PROSTHETIC HEME REACTIVITY - REACTION OF SUBSTRATES WITH THE HEME EDGE OF HORSERADISH-PEROXIDASE	162	19
464	5	6113 1988 BIOCHEMISTRY 27(15):5447-5454 ZANGER UM; VILBOIS F; HARDWICK JP; MEYER UA ABSENCE OF HEPATIC CYTOCHROME P450BUFI CAUSES GENETICALLY DEFICIENT DEBRISOQUINE OXIDATION IN MAN	162	58
465	7	8702 1993 JOURNAL OF CELL BIOLOGY 122(1):265-278 BRISTOW J; TEE MK; GITELMAN SE; MELLON SH; MILLER WL TENASCIN-X - A NOVEL EXTRACELLULAR-MATRIX PROTEIN ENCODED BY THE HUMAN XB GENE OVERLAPPING P450C21B	162	4
466	24	8809 1993 PHARMACOLOGY & THERAPEUTICS 57(2-3):237-257 MARTUCCI CP; FISHMAN J P450 ENZYMES OF ESTROGEN METABOLISM	162	15
467	2	1005 1969 BIOCHEMICAL PHARMACOLOGY 18(6):1403-& KRIEGER RI; WILKINSO.CF MICROSOMAL MIXED-FUNCTION OXIDASES IN INSECTS .I. LOCALIZATION AND PROPERTIES OF AN ENZYME SYSTEM EFFECTING ALDRINE EPOXIDATION IN LARVAE OF SOUTHERN ARMYWORM (PRODENIA ERIDANIA)	161	24
468	2	5974 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(20):7193-7197 CHUA SC; SZABO P; VITEK A; GRZESCHIK KH; JOHN M; WHITE PC CLONING OF CDNA-ENCODING STEROID 11-BETA-HYDROXYLASE (P450C11)	161	46
469	9	9402 1995 AMERICAN JOURNAL OF HUMAN GENETICS 57(3):651-660 FERNANDEZSALGUERO P; HOFFMAN SMG; CHOLERTON S; MOHRENWEISER H; RAUNIO H; RAUTIO A; PELKONEN O; HUANG JD; EVANS WE; IDLE JR; GONZALEZ FJ A GENETIC-POLYMORPHISM IN COUMARIN 7-HYDROXYLATION - SEQUENCE OF THE HUMAN CYP2A GENES AND IDENTIFICATION OF VARIANT CYP2A6 ALLELES	161	0
470	8	882 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(4):834-& HORGAN DJ; SINGER TP; CASIDA JE STUDIES ON RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE	160	22
471	9	1383 1970 LIFE SCIENCES PT-2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 9(20):1189-& YAFFE SJ PRESENCE OF A MONOOXYGENASE SYSTEM IN HUMAN FETAL LIVER MICROSOMES	160	34
472	17	2547 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(6):1747-1754 LEVIN W; RYAN D; WEST S; LU AYH PREPARATION OF PARTIALLY PURIFIED, LIPID DEPLETED CYTOCHROME-P- 450 AND REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE- CYTOCHROME-C REDUCTASE FROM RAT-LIVER MICROSOMES	160	64
473	12	4808 1983 BIOCHIMICA ET BIOPHYSICA ACTA 726(1):41-80 HANSFORD RG BIOENERGETICS IN AGING	160	0
474	9	7980 1992 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 34(3):256-261 SKJELBO E; BROSEN K INHIBITORS OF IMIPRAMINE METABOLISM BY HUMAN LIVER-MICROSOMES	160	35
475	29	8299 1992 PHARMACOLOGY & THERAPEUTICS 54(1):17-61 GUENGERICH FP METABOLIC-ACTIVATION OF CARCINOGENS	160	50
476	2	469 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 23(1):5-& IMAI Y; SATO R EVIDENCE FOR 2 FORMS OF P-450 HEMOPROTEIN IN MICROSOMAL MEMBRANES	159	100
477	2	949 1969 ANALYTICAL BIOCHEMISTRY 31(1-3):296-& FINCH PR; YUEN R; SCHACHTE.H; MOSCAREL.MA ENZYMIC METHODS FOR MICRO ASSAY OF D-MANNOSE, D-GLUCOSE, D- GALACTOSE, AND L-FUCOSE FROM ACID HYDROLYZATES OF GLYCOPROTEINS	159	1
478	4	1141 1969 MOLECULAR PHARMACOLOGY 5(1):1-& LEIBMAN KC EFFECTS OF METYRAPONE ON LIVER MICROSOMAL DRUG OXIDATIONS	159	74
479	17	2663 1975 ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY 26():117-126 MEEUSE BJD THERMOGENIC RESPIRATION IN AROIDS	159	0
480	87	10957 1998 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 38():389-430 Thummel KE; Wilkinson GR In vitro and in vivo drug interactions involving human CYP3A	159	26
481	2	6660 1989 JOURNAL OF CLINICAL INVESTIGATION 83(4):1326-1335 KENNEDY TP; RAO NV; HOPKINS C; PENNINGTON L; TOLLEY E; HOIDAL JR ROLE OF REACTIVE OXYGEN SPECIES IN REPERFUSION INJURY OF THE RABBIT LUNG	158	3
482	8	6717 1989 MOLECULAR PHARMACOLOGY 36(1):97-105 WRIGHTON SA; RING BJ; WATKINS PB; VANDENBRANDEN M IDENTIFICATION OF A POLYMORPHICALLY EXPRESSED MEMBER OF THE HUMAN CYTOCHROME P-450III FAMILY	158	83
483	6	7987 1992 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 1(6):485-489 HIRVONEN A; HUSGAFVELPURSIAINEN K; KARJALAINEN A; ANTTILA S; VAINIO H POINT-MUTATIONAL MSPI AND ILE-VAL POLYMORPHISMS CLOSELY LINKED IN THE CYP1A1 GENE - LACK OF ASSOCIATION WITH SUSCEPTIBILITY TO LUNG-CANCER IN A FINNISH STUDY POPULATION	158	18
484	2	614 1967 BIOCHEMICAL JOURNAL 103(1):183-& NEAL RA STUDIES ON METABOLISM OF DIETHYL 4-NITROPHENYL PHOSPHOROTHIONATE (PARATHION) IN VITRO	157	7
485	3	1297 1970 EUROPEAN JOURNAL OF BIOCHEMISTRY 14(1):75-& WEISS H; JAGOW GV; KLINGENB.M; BUCHER T CHARACTERIZATION OF NEUROSPORA-CRASSA MITOCHONDRIA PREPARED WITH A GRIND-MILL	157	8
486	21	2135 1973 BIOCHIMICA ET BIOPHYSICA ACTA 301(2):155-193 WIKSTROM MK DIFFERENT CYTOCHROME B COMPONENTS IN RESPIRATORY-CHAIN OF ANIMAL MITOCHONDRIA AND THEIR ROLE IN ELECTRON-TRANSPORT AND ENERGY CONSERVATION	157	15
487	1	7040 1990 EMBO JOURNAL 9(1):69-76 WILHELMSSON A; CUTHILL S; DENIS M; WIKSTROM AC; GUSTAFSSON JA; POELLINGER L THE SPECIFIC DNA-BINDING ACTIVITY OF THE DIOXIN RECEPTOR IS MODULATED BY THE 90 KD HEAT-SHOCK PROTEIN	157	19
488	3	7043 1990 ENDOCRINOLOGY 126(5):2493-2498 LORENCE MC; MURRY BA; TRANT JM; MASON JI HUMAN 3-BETA-HYDROXYSTEROID DEHYDROGENASE DELTA-5-]4-ISOMERASE FROM PLACENTA - EXPRESSION IN NONSTEROIDOGENIC CELLS OF A PROTEIN THAT CATALYZES THE DEHYDROGENATION ISOMERIZATION OF C21 AND C19 STEROIDS	157	17
489	6	8170 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(17):11789-11793 ALVAREZ J; MONTERO M; GARCIASANCHO J HIGH-AFFINITY INHIBITION OF CA2+-DEPENDENT K+ CHANNELS BY CYTOCHROME-P-450 INHIBITORS	157	20
490	5	361 1965 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 109(3):585-& BETZ A; CHANCE B PHASE RELATIONSHIP OF GLYCOLYTIC INTERMEDIATES IN YEAST CELLS WITH OSCILLATORY METABOLIC CONTROL	156	48
491	10	1020 1969 BIOCHEMISTRY 8(8):3464-& JEFCOATE CR; GAYLOR JL LIGAND INTERACTIONS WITH HEMOPROTEIN P-450 .2. INFLUENCE OF PHENOBARBITAL AND METHYLCHOLANTHRENE INDUCTION PROCESSES ON P- 450 SPECTRA	156	0
492	5	2451 1974 BIOCHEMISTRY 13(7):1543-1548 KNUTSON JC; DELUCA HF "25-HYDROXYVITAMIN-D3-24-HYDROXYLASE SUBCELLULAR LOCATION AND PROPERTIES	156	6
493	3	4621 1982 GASTROENTEROLOGY 82(1):84-88 KNODELL RG; HOLTZMAN JL; CRANKSHAW DL; STEELE NM; STANLEY LN DRUG-METABOLISM BY RAT AND HUMAN HEPATIC MICROSOMES IN RESPONSE TO INTERACTION WITH H2-RECEPTOR ANTAGONISTS	156	16
494	4	4657 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(11):6231-6241 AUGUSTO O; KUNZE KL; DEMONTELLANO PRO N-PHENYLPROTOPORPHYRIN-IX FORMATION IN THE HEMOGLOBIN- PHENYLHYDRAZINE REACTION - EVIDENCE FOR A PROTEIN-STABILIZED IRON-PHENYL INTERMEDIATE	156	43
495	3	6226 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(7):3348-3353 CRUSE I; MAINES MD EVIDENCE SUGGESTING THAT THE 2 FORMS OF HEME OXYGENASE ARE PRODUCTS OF DIFFERENT GENES	156	5
496	2	7722 1991 MOLECULAR ENDOCRINOLOGY 5(10):1552-1561 RICE DA; MOUW AR; BOGERD AM; PARKER KL A SHARED PROMOTER ELEMENT REGULATES THE EXPRESSION OF 3 STEROIDOGENIC ENZYMES	156	21
497	14	8105 1992 FASEB JOURNAL 6(2):745-748 GUENGERICH FP CHARACTERIZATION OF HUMAN CYTOCHROME-P450 ENZYMES	156	65
498	11	1802 1972 BIOCHEMICAL PHARMACOLOGY 21(21):2887-& NORRED WP; WADE AE DIETARY FATTY ACID-INDUCED ALTERATIONS OF HEPATIC MICROSOMAL DRUG-METABOLISM	155	18
499	12	3631 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(14):4874-4880 JONES DP; MASON HS GRADIENTS OF O2 CONCENTRATION IN HEPATOCYTES	155	11
500	31	3918 1979 MOLECULAR AND CELLULAR BIOCHEMISTRY 27(1):27-46 NEBERT DW MULTIPLE FORMS OF INDUCIBLE DRUG-METABOLIZING-ENZYMES - REASONABLE MECHANISM BY WHICH ANY ORGANISM CAN COPE WITH ADVERSITY	155	25

Page 1:  1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26  27
Generated by: HistCite(Vlad). Version: 2003.05.01