#	Cited nodes	Nodes / Authors	GCS	LCS
101	0	1200 1970 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 139(1):221-& TAUROG A; LOTHROP ML; ESTABROOK RW IMPROVEMENTS IN ISOLATION PROCEDURE FOR THYROID PEROXIDASE - NATURE OF HEME PROSTHETIC GROUP	105	105
102	13	1406 1970 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 66(4):1157-& TSAI R; YU CA; GUNSALUS IC; PEISACH J; BLUMBERG W; ORMEJOHN.WH; BEINERT H SPIN-STATE CHANGES IN CYTOCHROME-P-450CAM ON BINDING OF SPECIFIC SUBSTRATES	278	104
103	4	5472 1985 NATURE 314(6012):620-622 SCHWARTZMAN M; FERRERI NR; CARROLL MA; SONGUMIZE E; MCGIFF JC RENAL CYTOCHROME-P450-RELATED ARACHIDONATE METABOLITE INHIBITS (NA+ + K+)ATPASE	268	104
104	39	6919 1990 BIOCHEMISTRY 29(51):11280-11292 BRIAN WR; SARI MA; IWASAKI M; SHIMADA T; KAMINSKY LS; GUENGERICH FP CATALYTIC ACTIVITIES OF HUMAN LIVER CYTOCHROME-P-450-IIIA4 EXPRESSED IN SACCHAROMYCES-CEREVISIAE	194	104
105	53	6192 1988 ENDOCRINE REVIEWS 9(3):295-318 MILLER WL MOLECULAR-BIOLOGY OF STEROID-HORMONE SYNTHESIS	647	102
106	11	1317 1970 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 351(11):1359-& DIEHL H; SCHADELI.J; ULLRICH V STUDIES ON KINETICS OF CYTOCHROME P-450 REDUCTION IN RAT LIVER MICROSOMES	122	101
107	2	469 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 23(1):5-& IMAI Y; SATO R EVIDENCE FOR 2 FORMS OF P-450 HEMOPROTEIN IN MICROSOMAL MEMBRANES	159	100
108	14	1445 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 144(1):78-& WIEBEL FJ; LEUTZ JC; DIAMOND L; GELBOIN HV ARYL HYDROCARBON (BENZO[A]PYRENE) HYDROXYLASE IN MICROSOMES FROM RAT TISSUES - DIFFERENTIAL INHIBITION AND STIMULATION BY BENZOFLAVONES AND ORGANIC SOLVENTS	368	100
109	22	4209 1980 PHYSIOLOGICAL REVIEWS 60(4):1107-1166 GELBOIN HV BENZO[A]PYRENE METABOLISM, ACTIVATION, AND CARCINOGENESIS - ROLE AND REGULATION OF MIXED-FUNCTION OXIDASES AND RELATED ENZYMES	901	100
110	9	4732 1982 XENOBIOTICA 12(11):727-744 RYAN DE; THOMAS PE; REIK LM; LEVIN W PURIFICATION, CHARACTERIZATION AND REGULATION OF 5 RAT HEPATIC- MICROSOMAL CYTOCHROME-P-450 ISOZYMES	309	100
111	8	7276 1990 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87(12):4790-4793 AOYAMA T; YAMANO S; GUZELIAN PS; GELBOIN HV; GONZALEZ FJ 5 OF 12 FORMS OF VACCINIA VIRUS-EXPRESSED HUMAN HEPATIC CYTOCHROME-P450 METABOLICALLY ACTIVATE AFLATOXIN-B1	220	99
112	41	7352 1991 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 31():339-369 MCGIFF JC CYTOCHROME-P-450 METABOLISM OF ARACHIDONIC-ACID	227	99
113	6	1439 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 143(1):46-& COHEN BS; ESTABROOK RW MICROSOMAL ELECTRON TRANSPORT REACTIONS .2. USE OF REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE AND/OR REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE FOR OXIDATIVE N-DEMETHYLATION OF AMINOPYRINE AND OTHER DRUG SUBSTRATES	98	98
114	18	4504 1982 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 216(1):272-288 RYAN DE; THOMAS PE; LEVIN W PURIFICATION AND CHARACTERIZATION OF A MINOR FORM OF HEPATIC- MICROSOMAL CYTOCHROME-P-450 FROM RATS TREATED WITH POLYCHLORINATED-BIPHENYLS	265	98
115	5	6135 1988 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 26(4):363-372 SESARDIC D; BOOBIS AR; EDWARDS RJ; DAVIES DS A FORM OF CYTOCHROME-P450 IN MAN, ORTHOLOGOUS TO FORM D IN THE RAT, CATALYZES THE O-DEETHYLATION OF PHENACETIN AND IS INDUCIBLE BY CIGARETTE-SMOKING	211	98
116	7	6556 1989 DRUG METABOLISM AND DISPOSITION 17(2):197-207 COMBALBERT J; FABRE I; FABRE G; DALET I; DERANCOURT J; CANO JP; MAUREL P METABOLISM OF CYCLOSPORINE-A .4. PURIFICATION AND IDENTIFICATION OF THE RIFAMPICIN-INDUCIBLE HUMAN-LIVER CYTOCHROME-P-450 (CYCLOSPORINE-A OXIDASE) AS A PRODUCT OF P450IIIA GENE SUBFAMILY	269	97
117	10	1622 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(13):4143-& MASTERS BSS; BARON J; TAYLOR WE; ISAACSON EL; LOSPALLU.J IMMUNOCHEMICAL STUDIES ON ELECTRON TRANSPORT CHAINS INVOLVING CYTOCHROME P-450 .1. EFFECTS OF ANTIBODIES TO PIG LIVER MICROSOMAL REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME-C REDUCTASE AND NON-HEME IRON PROTEIN FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	221	96
118	13	4763 1983 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 225(2):758-770 KAMATAKI T; MAEDA K; YAMAZOE Y; NAGAI T; KATO R SEX DIFFERENCE OF CYTOCHROME-P-450 IN THE RAT - PURIFICATION, CHARACTERIZATION, AND QUANTITATION OF CONSTITUTIVE FORMS OF CYTOCHROME-P-450 FROM LIVER-MICROSOMES OF MALE AND FEMALE RATS	279	96
119	5	168 1962 BIOCHIMICA ET BIOPHYSICA ACTA 60(2):236-& ESTABROOK RW OBSERVATIONS ON ANTIMYCIN A INHIBITION OF BIOLOGICAL OXIDATIONS .1. STOICHIOMETRY AND PH EFFECTS	95	95
120	29	5531 1986 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 26():333-369 WHITLOCK JP THE REGULATION OF CYTOCHROME-P-450 GENE-EXPRESSION	310	95
121	11	6641 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(19):10987-10995 RUETTINGER RT; WEN LP; FULCO AJ CODING NUCLEOTIDE, 5' REGULATORY, AND DEDUCED AMINO-ACID SEQUENCES OF P-450BM-3, A SINGLE PEPTIDE CYTOCHROME P-450- NADPH-P-450 REDUCTASE FROM BACILLUS-MEGATERIUM	150	94
122	6	1349 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(10):2505-& LIEBER CS; DECARLI LM HEPATIC MICROSOMAL ETHANOL-OXIDIZING SYSTEM - IN-VITRO CHARACTERISTICS AND ADAPTIVE PROPERTIES IN-VIVO	681	92
123	6	1668 1971 METABOLISM-CLINICAL AND EXPERIMENTAL 20(2):187-& ESTABROOK RW; FRANKLIN MR; COHEN B; SHIGAMAT.A; HILDEBRANDT AG INFLUENCE OF HEPATIC MICROSOMAL MIXED FUNCTION OXIDATION REACTIONS ON CELLULAR METABOLIC CONTROL	92	92
124	48	7258 1990 PHARMACOLOGICAL REVIEWS 42(2):85-101 MURRAY M; REIDY GF SELECTIVITY IN THE INHIBITION OF MAMMALIAN CYTOCHROMES-P-450 BY CHEMICAL-AGENTS	254	92
125	2	667 1967 EUROPEAN JOURNAL OF BIOCHEMISTRY 2(3):275-& SIMPSON ER; BOYD GS CHOLESTEROL SIDE-CHAIN CLEAVAGE SYSTEM OF BOVINE ADRENAL CORTEX	195	91
126	13	2519 1974 EUROPEAN JOURNAL OF BIOCHEMISTRY 46(1):99-106 STAUDT H; LICHTENB.F; ULLRICH V ROLE OF NADH IN UNCOUPLED MICROSOMAL MONOXYGENATIONS	140	91
127	6	5559 1986 BIOCHEMICAL PHARMACOLOGY 35(3):487-491 SHEETS JJ; MASON JI; WISE CA; ESTABROOK RW INHIBITION OF RAT-LIVER MICROSOMAL CYTOCHROME-P-450 STEROID HYDROXYLASE REACTIONS BY IMIDAZOLE ANTIMYCOTIC AGENTS	91	91
128	21	3799 1979 BIOCHIMICA ET BIOPHYSICA ACTA 550(2):341-356 TANIGUCHI H; IMAI Y; IYANAGI T; SATO R INTERACTION BETWEEN NADPH-CYTOCHROME P-450 REDUCTASE AND CYTOCHROME-P-450 IN THE MEMBRANE OF PHOSPHATIDYLCHOLINE VESICLES	170	90
129	4	4510 1982 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 104(3):916-922 CHACOS N; FALCK JR; WIXTROM C; CAPDEVILA J NOVEL EPOXIDES FORMED DURING THE LIVER CYTOCHROME-P-450 OXIDATION OF ARACHIDONIC-ACID	128	90
130	1	19 1957 METHODS IN ENZYMOLOGY 4():273-329 CHANCE B TECHNIQUES FOR THE ASSAY OF THE RESPIRATORY ENZYMES	402	89
131	1	152 1962 ANALYTICAL BIOCHEMISTRY 4(3):231-& ESTABROOK RW FLUOROMETRIC MEASUREMENT OF REDUCED PYRIDINE NUCLEOTIDE IN CELLULAR AND SUBCELLULAR PARTICLES	89	89
132	7	666 1967 EUROPEAN JOURNAL OF BIOCHEMISTRY 1(4):419-& IMAI Y; SATO R CONVERSION OF P-450 TO P-420 BY NEUTRAL SALTS AND SOME OTHER REAGENTS	175	89
133	11	2558 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(17):5373-5378 THOMPSON EA; SIITERI PK INVOLVEMENT OF HUMAN PLACENTAL MICROSOMAL CYTOCHROME-P-450 IN AROMATIZATION	450	89
134	19	7734 1991 MOLECULAR PHARMACOLOGY 40(5):679-685 YUN CH; SHIMADA T; GUENGERICH FP PURIFICATION AND CHARACTERIZATION OF HUMAN LIVER MICROSOMAL CYTOCHROME-P-450 2A6	202	89
135	4	4273 1981 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 101(4):1357-1363 CAPDEVILA J; PARKHILL L; CHACOS N; OKITA R; MASTERS BSS; ESTABROOK RW THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID BY PURIFIED CYTOCHROMES P-450	88	88
136	21	5122 1984 EUROPEAN JOURNAL OF BIOCHEMISTRY 139(2):235-246 TAMBURINI PP; MASSON HA; BAINS SK; MAKOWSKI RJ; MORRIS B; GIBSON GG MULTIPLE FORMS OF HEPATIC CYTOCHROME-P-450 - PURIFICATION, CHARACTERIZATION AND COMPARISON OF A NOVEL CLOFIBRATE-INDUCED ISOZYME WITH OTHER MAJOR FORMS OF CYTOCHROME-P-450	204	88
137	4	6177 1988 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 7(6):379-387 HEILMANN LJ; SHEEN YY; BIGELOW SW; NEBERT DW TROUT-P450IA1 - CDNA AND DEDUCED PROTEIN-SEQUENCE, EXPRESSION IN LIVER, AND EVOLUTIONARY SIGNIFICANCE	191	88
138	8	8316 1992 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89(22):10817-10821 FISHER CW; SHET MS; CAUDLE DL; MARTINWIXTROM CA; ESTABROOK RW HIGH-LEVEL EXPRESSION IN ESCHERICHIA-COLI OF ENZYMATICALLY ACTIVE FUSION PROTEINS CONTAINING THE DOMAINS OF MAMMALIAN CYTOCHROMES-P450 AND NADPH-P450 REDUCTASE FLAVOPROTEIN	88	88
139	54	2462 1974 BIOCHIMICA ET BIOPHYSICA ACTA 344(2):205-240 LU AYH; LEVIN W RESOLUTION AND RECONSTITUTION OF LIVER MICROSOMAL HYDROXYLATION SYSTEM	252	87
140	19	8834 1993 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90(24):11748-11752 SHET MS; FISHER CW; HOLMANS PL; ESTABROOK RW HUMAN CYTOCHROME-P450-3A4 - ENZYMATIC-PROPERTIES OF A PURIFIED RECOMBINANT FUSION PROTEIN CONTAINING NADPH-P450 REDUCTASE	87	87
141	31	2562 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(21):6701-6709 LU AYH; WEST SB; VORE M; RYAN D; LEVIN W ROLE OF CYTOCHROME-B5 IN HYDROXYLATION BY A RECONSTITUTED CYTOCHROME P-450-CONTAINING SYSTEM	120	86
142	4	4859 1983 ENDOCRINOLOGY 113(1):421-423 CAPDEVILA J; CHACOS N; FALCK JR; MANNA S; NEGROVILAR A; OJEDA SR NOVEL HYPOTHALAMIC ARACHIDONATE PRODUCTS STIMULATE SOMATOSTATIN RELEASE FROM THE MEDIAN-EMINENCE	137	86
143	9	7025 1990 DRUG METABOLISM AND DISPOSITION 18(5):595-606 PICHARD L; FABRE I; FABRE G; DOMERGUE J; SAINTAUBERT B; MOURAD G; MAUREL P CYCLOSPORINE-A DRUG-INTERACTIONS - SCREENING FOR INDUCERS AND INHIBITORS OF CYTOCHROME-P-450 (CYCLOSPORINE-A OXIDASE) IN PRIMARY CULTURES OF HUMAN HEPATOCYTES AND IN LIVER-MICROSOMES	347	86
144	6	7181 1990 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 253(1):387-394 DEWAZIERS I; CUGNENC PH; YANG CS; LEROUX JP; BEAUNE PH CYTOCHROME-P-450 ISOENZYMES, EPOXIDE HYDROLASE AND GLUTATHIONE TRANSFERASES IN RAT AND HUMAN HEPATIC AND EXTRAHEPATIC TISSUES	270	86
145	3	1465 1971 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42(1):140-& ISHIMURA Y; ULLRICH V; PETERSON JA OXYGENATED CYTOCHROME-P-450 AND ITS POSSIBLE ROLE IN ENZYMIC HYDROXYLATION	130	85
146	8	1880 1972 EUROPEAN JOURNAL OF BIOCHEMISTRY 25(3):420-& THURMAN RG; SCHOLZ R; LEY HG HEPATIC MICROSOMAL ETHANOL OXIDATION - HYDROGEN-PEROXIDE FORMATION AND ROLE OF CATALASE	467	85
147	73	5750 1987 ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 60():35-87 BLACK SD; COON MJ P-450 CYTOCHROMES - STRUCTURE AND FUNCTION	162	85
148	4	6115 1988 BIOCHEMISTRY 27(18):6929-6940 GED C; UMBENHAUER DR; BELLEW TM; BORK RW; SRIVASTAVA PK; SHINRIKI N; LLOYD RS; GUENGERICH FP CHARACTERIZATION OF CDNAS, MESSENGER-RNAS, AND PROTEINS RELATED TO HUMAN-LIVER MICROSOMAL CYTOCHROME-P-450 (S)-MEPHENYTOIN 4'- HYDROXYLASE	134	85
149	20	1813 1972 BIOCHEMISTRY 11(23):4243-& SCHENKMAN JB; MOLDEUS P; ORRENIUS S; KRASCHNI.R; CINTI DL NATURE OF REVERSE TYPE I (MODIFIED TYPE II) SPECTRAL CHANGE IN LIVER-MICROSOMES	106	84
150	26	5530 1986 ANNUAL REVIEW OF BIOCHEMISTRY 55():69-102 NEEDLEMAN P; TURK J; JAKSCHIK BA; MORRISON AR; LEFKOWITH JB ARACHIDONIC-ACID METABOLISM	1177	84
151	6	6631 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(6):3568-3572 SONG BJ; VEECH RL; PARK SS; GELBOIN HV; GONZALEZ FJ INDUCTION OF RAT HEPATIC N-NITROSODIMETHYLAMINE DEMETHYLASE BY ACETONE IS DUE TO PROTEIN STABILIZATION	209	84
152	1	236 1963 JOURNAL OF BIOLOGICAL CHEMISTRY 238(3):1124-& ERNSTER L; AZZONE GF; DALLNER G DIFFERENTIAL EFFECTS OF ROTENONE AND AMYTAL ON MITOCHONDRIAL ELECTRON AND ENERGY TRANSFER	361	83
153	6	1145 1969 MOLECULAR PHARMACOLOGY 5(2):186-& SLADEK NE; MANNERIN.GJ INDUCTION OF DRUG METABOLISM .2. QUALITATIVE DIFFERENCES IN MICROSOMAL N-DEMETHYLATING SYSTEMS STIMULATED BY POLYCYCLIC HYDROCARBONS AND BY PHENOBARBITAL	163	83
154	7	2677 1975 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 171(2):385-397 HILDEBRANDT AG; ROOTS I REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH)- DEPENDENT FORMATION AND BREAKDOWN OF HYDROGEN-PEROXIDE DURING MIXED-FUNCTION OXIDATION REACTIONS IN LIVER-MICROSOMES	258	83
155	8	6717 1989 MOLECULAR PHARMACOLOGY 36(1):97-105 WRIGHTON SA; RING BJ; WATKINS PB; VANDENBRANDEN M IDENTIFICATION OF A POLYMORPHICALLY EXPRESSED MEMBER OF THE HUMAN CYTOCHROME P-450III FAMILY	158	83
156	6	787 1968 BIOCHEMICAL JOURNAL 110(3):407-& HOLTZMAN JL; GRAM TE; GIGON PL; GILLETTE JR DISTRIBUTION OF COMPONENTS OF MIXED-FUNCTION OXIDASE BETWEEN ROUGH AND SMOOTH ENDOPLASMIC RETICULUM OF LIVER CELLS	185	82
157	8	6462 1989 BIOCHEMISTRY 28(12):4993-4999 BRIAN WR; SRIVASTAVA PK; UMBENHAUER DR; LLOYD RS; GUENGERICH FP EXPRESSION OF A HUMAN-LIVER CYTOCHROME-P-450 PROTEIN WITH TOLBUTAMIDE HYDROXYLASE-ACTIVITY IN SACCHAROMYCES-CEREVISIAE	153	82
158	4	6628 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(2):910-919 BORK RW; MUTO T; BEAUNE PH; SRIVASTAVA PK; LLOYD RS; GUENGERICH FP CHARACTERIZATION OF MESSENGER-RNA SPECIES RELATED TO HUMAN- LIVER CYTOCHROME-P-450 NIFEDIPINE OXIDASE AND THE REGULATION OF CATALYTIC ACTIVITY	122	82
159	37	9878 1995 STRUCTURE 3(1):41-62 HASEMANN CA; KURUMBAIL RG; BODDUPALLI SS; PETERSON JA; DEISENHOFER J STRUCTURE AND FUNCTION OF CYTOCHROMES-P450 - A COMPARATIVE- ANALYSIS OF 3 CRYSTAL-STRUCTURES	191	82
160	115	10668 1997 DRUG METABOLISM REVIEWS 29(1-2):413-580 Rendic S; DiCarlo FJ Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors	271	82
161	1	306 1964 BIOCHIMICA ET BIOPHYSICA ACTA 92(2):415-& HARDING BW; WONG SH; NELSON DH CARBON MONOXIDE-COMBINING SUBSTANCES IN RAT ADRENAL	103	81
162	21	1385 1970 MOLECULAR PHARMACOLOGY 6(3):213-& LU AYH; STROBEL HW; COON MJ PROPERTIES OF A SOLUBILIZED FORM OF CYTOCHROME P-450-CONTAINING MIXED-FUNCTION OXIDASE OF LIVER MICROSOMES	176	81
163	14	2124 1973 BIOCHEMISTRY 12(12):2297-2308 IYANAGI T; MASON HS SOME PROPERTIES OF HEPATIC REDUCED NICOTINAMIDE ADENINE- DINUCLEOTIDE PHOSPHATE - CYTOCHROME-C REDUCTASE	279	81
164	8	2208 1973 DRUG METABOLISM AND DISPOSITION 1(1):350-357 ORRENIUS S; ELLIN A; JAKOBSSO.SV; THOR H; CINTI DL; SCHENKMAN JB; ESTABROOK RW CYTOCHROME P-450-CONTAINING MONO-OXYGENASE SYSTEM OF RAT-KIDNEY CORTEX MICROSOMES	80	81
165	3	6623 1989 JOURNAL OF BIOCHEMISTRY 105(2):161-163 KOMORI M; NISHIO K; OHI H; KITADA M; KAMATAKI T MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF CDNA CONTAINING THE ENTIRE CODING REGION FOR HUMAN-FETAL LIVER CYTOCHROME-P-450	104	81
166	18	7369 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 290(1):160-166 WAXMAN DJ; LAPENSON DP; AOYAMA T; GELBOIN HV; GONZALEZ FJ; KORZEKWA K STEROID-HORMONE HYDROXYLASE SPECIFICITIES OF 11 CDNA-EXPRESSED HUMAN CYTOCHROME-P450S	187	81
167	13	4650 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(8):4404-4411 JONEN HG; WERRINGLOER J; PROUGH RA; ESTABROOK RW THE REACTION OF PHENYLHYDRAZINE WITH MICROSOMAL CYTOCHROME-P- 450 - CATALYSIS OF HEME MODIFICATION	80	80
168	10	5862 1987 CIRCULATION RESEARCH 60(1):50-59 PROCTOR KG; FALCK JR; CAPDEVILA J INTESTINAL VASODILATION BY EPOXYEICOSATRIENOIC ACIDS - ARACHIDONIC-ACID METABOLITES PRODUCED BY A CYTOCHROME-P450 MONOOXYGENASE	134	80
169	14	3637 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(21):7931-7939 GUENGERICH FP SEPARATION AND PURIFICATION OF MULTIPLE FORMS OF MICROSOMAL CYTOCHROME-P-450 - PARTIAL CHARACTERIZATION OF 3 APPARENTLY HOMOGENEOUS CYTOCHROMES P-450 PREPARED FROM LIVERS OF PHENOBARBITAL-TREATED AND 3-METHYLCHOLANTHRENE-TREATED RATS	295	79
170	5	895 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(14):3912-& CONNEY AH; LEVIN W; IKEDA M; KUNTZMAN R; COOPER DY; ROSENTHA.O INHIBITORY EFFECT OF CARBON MONOXIDE ON HYDROXYLATION OF TESTOSTERONE BY RAT LIVER MICROSOMES	127	78
171	8	1138 1969 LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 8(2P2):85-& DAVIES DS; GIGON PL; GILLETTE JR SPECIES AND SEX DIFFERENCES IN ELECTRON TRANSPORT SYSTEMS IN LIVER MICROSOMES AND THEIR RELATIONSHIP TO ETHYLMORPHINE DEMETHYLATION	129	78
172	69	4346 1981 DRUG METABOLISM REVIEWS 12(1):1-117 TESTA B; JENNER P INHIBITORS OF CYTOCHROME P-450S AND THEIR MECHANISM OF ACTION	330	78
173	5	6283 1988 MOLECULAR PHARMACOLOGY 33(5):500-508 GUENGERICH FP OXIDATION OF 17 ALPHA-ETHYNYLESTRADIOL BY HUMAN-LIVER CYTOCHROME-P-450	185	78
174	5	6659 1989 JOURNAL OF CLINICAL INVESTIGATION 83(2):688-697 WATKINS PB; MURRAY SA; WINKELMAN LG; HEUMAN DM; WRIGHTON SA; GUZELIAN PS ERYTHROMYCIN BREATH TEST AS AN ASSAY OF GLUCOCORTICOID- INDUCIBLE LIVER CYTOCHROMES P-450 - STUDIES IN RATS AND PATIENTS	254	78
175	29	6990 1990 CHEMICAL RESEARCH IN TOXICOLOGY 3(4):363-371 GUENGERICH FP MECHANISM-BASED INACTIVATION OF HUMAN LIVER MICROSOMAL CYTOCHROME-P-450-IIIA4 BY GESTODENE	200	78
176	7	7129 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(8):4233-4239 BODDUPALLI SS; ESTABROOK RW; PETERSON JA FATTY-ACID MONOOXYGENATION BY CYTOCHROME-P-450BM-3	78	78
177	9	1438 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 143(1):37-& COHEN BS; ESTABROOK RW MICROSOMAL ELECTRON TRANSPORT REACTIONS .1. INTERACTION OF REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE DURING OXIDATIVE DEMETHYLATION OF AMINOPYRINE AND CYTOCHROME B5 REDUCTION	77	77
178	12	2786 1975 DRUG METABOLISM AND DISPOSITION 3(4):245-253 BURKE MD; MAYER RT INHERENT SPECIFICITIES OF PURIFIED CYTOCHROMES P-450 AND P-448 TOWARD BIPHENYL HYDROXYLATION AND ETHOXYRESORUFIN DE-ETHYLATION	215	77
179	6	6754 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(20):7823-7827 IMAI M; SHIMADA H; WATANABE Y; MATSUSHIMAHIBIYA Y; MAKINO R; KOGA H; HORIUCHI T; ISHIMURA Y UNCOUPLING OF THE CYTOCHROME P-450CAM MONOOXYGENASE REACTION BY A SINGLE MUTATION, THREONINE-252 TO ALANINE OR VALINE - A POSSIBLE ROLE OF THE HYDROXY AMINO-ACID IN OXYGEN ACTIVATION	197	77
180	6	2280 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(6):2089-2094 CHU JW; KIMURA T STUDIES ON ADRENAL STEROID HYDROXYLASES - MOLECULAR AND CATALYTIC PROPERTIES OF ADRENODOXIN REDUCTASE (A FLAVOPROTEIN)	130	76
181	21	2330 1973 MOLECULAR PHARMACOLOGY 9(4):455-469 CORREIA MA; MANNERIN.GJ REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE SYNERGISM OF REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE-DEPENDENT MIXED-FUNCTION OXIDASE SYSTEM OF HEPATIC MICROSOMES .1. EFFECTS OF ACTIVATION AND INHIBITION OF FATTY ACYL COENZYME A DESATURATION SYSTEM	91	76
182	41	2507 1974 DRUG METABOLISM REVIEWS 3(1):1-32 KATO R SEX-RELATED DIFFERENCES IN DRUG-METABOLISM	419	76
183	22	4606 1982 EUROPEAN JOURNAL OF BIOCHEMISTRY 126(3):583-588 KUTHAN H; ULLRICH V OXIDASE AND OXYGENASE FUNCTION OF THE MICROSOMAL CYTOCHROME- P450 MONO-OXYGENASE SYSTEM	152	75
184	12	6497 1989 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 28(4):373-387 GED C; ROUILLON JM; PICHARD L; COMBALBERT J; BRESSOT N; BORIES P; MICHEL H; BEAUNE P; MAUREL P THE INCREASE IN URINARY-EXCRETION OF 6-BETA-HYDROXYCORTISOL AS A MARKER OF HUMAN HEPATIC CYTOCHROME-P450IIIA INDUCTION	257	75
185	12	6967 1990 CANCER RESEARCH 50(11):3367-3376 MCMANUS ME; BURGESS WM; VERONESE ME; HUGGETT A; QUATTROCHI LC; TUKEY RH METABOLISM OF 2-ACETYLAMINOFLUORENE AND BENZO(A)PYRENE AND ACTIVATION OF FOOD-DERIVED HETEROCYCLIC AMINE MUTAGENS BY HUMAN CYTOCHROMES-P-450	245	75
186	2	281 1964 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 14(4):329-& ORRENIUS S; DALLNER G; ERNSTER L INHIBITION OF TPNH-LINKED LIPID PEROXIDATION OF LIVER MICROSOMES BY DRUGS UNDERGOING OXIDATIVE DEMETHYLATION	213	74
187	8	1024 1969 BIOCHIMICA ET BIOPHYSICA ACTA 171(1):23-& SCHENKMAN JB; GREIM H; ZANGE M; REMMER H ON PROBLEM OF POSSIBLE OTHER FORMS OF CYTOCHROME P450 IN LIVER MICROSOMES	86	74
188	4	1141 1969 MOLECULAR PHARMACOLOGY 5(1):1-& LEIBMAN KC EFFECTS OF METYRAPONE ON LIVER MICROSOMAL DRUG OXIDATIONS	159	74
189	4	1348 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(9):2438-& KOWAL J; SIMPSON ER; ESTABROOK RW ADRENAL CELLS IN TISSUE CULTURE .5. ON SPECIFICITY OF STIMULATION OF 11BETA-HYDROXYLATION BY ADRENOCORTICOTROPIN	74	74
190	9	2970 1976 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 70(3):951-956 GUENGERICH FP; BALLOU DP; COON MJ SPECTRAL INTERMEDIATES IN REACTION OF OXYGEN WITH PURIFIED LIVER MICROSOMAL CYTOCHROME-P-450	100	74
191	8	5871 1987 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 6(2):149-161 GONZALEZ FJ; MATSUNAGA T; NAGATA K; MEYER UA; NEBERT DW; PASTEWKA J; KOZAK CA; GILLETTE J; GELBOIN HV; HARDWICK JP DEBRISOQUINE 4-HYDROXYLASE - CHARACTERIZATION OF A NEW P450 GENE SUBFAMILY, REGULATION, CHROMOSOMAL MAPPING, AND MOLECULAR ANALYSIS OF THE DA RAT POLYMORPHISM	150	74
192	6	6507 1989 CANCER RESEARCH 49(9):2337-2343 WU HQ; MASSETBROWN J; TWEEDIE DJ; MILEWICH L; FRENKEL RA; MARTINWIXTROM C; ESTABROOK RW; PROUGH RA INDUCTION OF MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE AND CYTOCHROME P-450IVA1 (P-450LA-OMEGA) BY DEHYDROEPIANDROSTERONE IN RATS - A POSSIBLE PEROXISOMAL PROLIFERATOR	74	74
193	24	8910 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 309(1):168-177 SANDHU P; GUO ZY; BABA T; MARTIN MV; TUKEY RH; GUENGERICH FP EXPRESSION OF MODIFIED HUMAN CYTOCHROME-P450 1A2 IN ESCHERICHIA-COLI - STABILIZATION, PURIFICATION, SPECTRAL CHARACTERIZATION, AND CATALYTIC ACTIVITIES OF THE ENZYME	111	74
194	9	1087 1969 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 350(3):357-& ULLRICH V ON HYDROXYLATION OF CYCLOHEXANE IN RAT LIVER MICROSOMES	105	73
195	8	3259 1977 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 75(2):420-426 IMAI Y; SATO R ROLES OF CYTOCHROME B5 IN A RECONSTITUTED N-DEMETHYLASE SYSTEM CONTAINING CYTOCHROME-P-450	98	73
196	6	6032 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 263(1):59-68 HALPERT JR MULTIPLICITY OF STEROID-INDUCIBLE CYTOCHROMES-P-450 IN RAT- LIVER MICROSOMES	102	73
197	7	6637 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(14):8222-8229 ANDERSSON S; DAVIS DL; DAHLBACK H; JORNVALL H; RUSSELL DW CLONING, STRUCTURE, AND EXPRESSION OF THE MITOCHONDRIAL CYTOCHROME-P-450 STEROL 26-HYDROXYLASE, A BILE-ACID BIOSYNTHETIC ENZYME	1078	73
198	8	7180 1990 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 252(1):442-447 RELLING MV; AOYAMA T; GONZALEZ FJ; MEYER UA TOLBUTAMIDE AND MEPHENYTOIN HYDROXYLATION BY HUMAN CYTOCHROME- P450S IN THE CYP2C SUBFAMILY	200	73
199	19	2846 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(6):2157-2163 RYAN D; LU AYH; WEST S; LEVIN W MULTIPLE FORMS OF CYTOCHROME-P-450 IN PHENOBARBITAL-TREATED RATS AND 3-METHYLCHOLANTHRENE-TREATED RATS - SEPARATION AND SPECTRAL PROPERTIES	181	72
200	3	4984 1983 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80(11):3504-3507 SNYDER GD; CAPDEVILA J; CHACOS N; MANNA S; FALCK JR ACTION OF LUTEINIZING-HORMONE-RELEASING HORMONE - INVOLVEMENT OF NOVEL ARACHIDONIC-ACID METABOLITES	166	72

#	Cited nodes	Nodes / Authors	GCS	LCS
201	5	5970 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(2):407-411 CHUNG BC; PICADOLEONARD J; HANIU M; BIENKOWSKI M; HALL PF; SHIVELY JE; MILLER WL CYTOCHROME P450C17 (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - CLONING OF HUMAN ADRENAL AND TESTIS CDNAS INDICATES THE SAME GENE IS EXPRESSED IN BOTH TISSUES	243	72
202	15	6512 1989 CANCER RESEARCH 49(22):6304-6312 SHIMADA T; MARTIN MV; PRUESSSCHWARTZ D; MARNETT LJ; GUENGERICH FP ROLES OF INDIVIDUAL HUMAN CYTOCHROME-P-450 ENZYMES IN THE BIOACTIVATION OF BENZO(A)PYRENE, 7,8-DIHYDROXY-7,8- DIHYDROBENZO(A)PYRENE, AND OTHER DIHYDRODIOL DERIVATIVES OF POLYCYCLIC AROMATIC-HYDROCARBONS	176	72
203	13	8106 1992 FASEB JOURNAL 6(2):759-764 FISHER CW; CAUDLE DL; MARTINWIXTROM C; QUATTROCHI LC; TUKEY RH; WATERMAN MR; ESTABROOK RW HIGH-LEVEL EXPRESSION OF FUNCTIONAL HUMAN CYTOCHROME-P450 1A2 IN ESCHERICHIA-COLI	72	72
204	18	1389 1970 MOLECULAR PHARMACOLOGY 6(6):631-& CHAPLIN MD; MANNERIN.GJ ROLE OF PHOSPHOLIPIDS IN HEPATIC MICROSOMAL DRUG-METABOLIZING SYSTEM	150	71
205	14	1739 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 150(1):64-& ELLIN A; SCHENKMAN JB; JAKOBSSO.SV; ORRENIUS S CYTOCHROME P450K OF RAT-KIDNEY CORTEX MICROSOMES - ITS INVOLVEMENT IN FATTY-ACID OMEGA-HYDROXYLATION AND(OMEGA-1)- HYDROXYLAATION	123	71
206	13	3995 1980 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 200(1):186-195 CAPDEVILA J; ESTABROOK RW; PROUGH RA DIFFERENCES IN THE MECHANISM OF NADPH-SUPPORTED AND CUMENE HYDROPEROXIDE-SUPPORTED REACTIONS OF CYTOCHROME-P-450	71	71
207	8	4523 1982 BIOCHEMICAL JOURNAL 203(1):161-168 GIBSON GG; ORTON TC; TAMBURINI PP CYTOCHROME-P-450 INDUCTION BY CLOFIBRATE - PURIFICATION AND PROPERTIES OF A HEPATIC CYTOCHROME-P-450 RELATIVELY SPECIFIC FOR THE 12-HYDROXYLATION AND 11-HYDROXYLATION OF DODECANOIC ACID (LAURIC-ACID)	242	71
208	20	4802 1983 BIOCHEMISTRY 22(20):4846-4855 WAXMAN DJ; WALSH C CYTOCHROME-P-450 ISOZYME-1 FROM PHENOBARBITAL-INDUCED RAT-LIVER - PURIFICATION, CHARACTERIZATION, AND INTERACTIONS WITH METYRAPONE AND CYTOCHROME-B5	162	71
209	2	5662 1986 HEPATOLOGY 6(1):36-45 BERGER ML; BHATT H; COMBES B; ESTABROOK RW CCL4-INDUCED TOXICITY IN ISOLATED HEPATOCYTES - THE IMPORTANCE OF DIRECT SOLVENT INJURY	71	71
210	9	6654 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(35):21327-21333 AOYAMA T; KORZEKWA K; NAGATA K; ADESNIK M; REISS A; LAPENSON DP; GILLETTE J; GELBOIN HV; WAXMAN DJ; GONZALEZ FJ SEQUENCE REQUIREMENTS FOR CYTOCHROME P-450IIB1 CATALYTIC ACTIVITY - ALTERATION OF THE STEREOSPECIFICITY AND REGIOSELECTIVITY OF STEROID HYDROXYLATION BY A SIMULTANEOUS CHANGE OF 2 HYDROPHOBIC AMINO-ACID RESIDUES TO PHENYLALANINE	102	71
211	12	3338 1977 DRUG METABOLISM AND DISPOSITION 5(1):1-8 BURKE MD; PROUGH RA; MAYER RT CHARACTERISTICS OF A MICROSOMAL CYTOCHROME P-448-MEDIATED REACTION ETHOXYRESORUFIN O-DE-ETHYLATION	240	70
212	4	5723 1986 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83(13):4715-4719 JOHN ME; JOHN MC; BOGGARAM V; SIMPSON ER; WATERMAN MR TRANSCRIPTIONAL REGULATION OF STEROID HYDROXYLASE GENES BY CORTICOTROPIN	217	70
213	13	8985 1994 BIOCHEMISTRY 33(7):1743-1752 GOLDSTEIN JA; FALETTO MB; ROMKESSPARKS M; SULLIVAN T; KITAREEWAN S; RAUCY JL; LASKER JM; GHANAYEM BI EVIDENCE THAT CYP2C19 IS THE MAJOR (S)-MEPHENYTOIN 4'- HYDROXYLASE IN HUMANS	270	70
214	1	27 1958 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 78(1):66-82 LINDENMAYER A; ESTABROOK RW LOW-TEMPERATURE SPECTRAL STUDIES ON THE BIOSYNTHESIS OF CYTOCHROMES IN BAKERS YEAST	69	69
215	9	459 1966 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 114(2):239-& TYLER DD; ESTABROOK RW; SANADI DR STUDIES OF OXIDATIVE PHOSPHORYLATION AND ENERGY-LINKED CYTOCHROME B REDUCTION WITH TETRAMETHYL-P-PHENYLENE DIAMINE AS SUBSTRATE	69	69
216	11	1098 1969 JOURNAL OF BIOCHEMISTRY 65(2):269-& MITANI F; HORIE S STUDIES ON P-450 .V. ON SUBSTRATE-INDUCED SPECTRAL CHANGE OF P- 450 SOLUBILIZED FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	97	69
217	24	4696 1982 PHARMACOLOGICAL REVIEWS 34(2):189-222 PELKONEN O; NEBERT DW METABOLISM OF POLYCYCLIC AROMATIC-HYDROCARBONS - ETIOLOGIC ROLE IN CARCINOGENESIS	408	68
218	8	6913 1990 BIOCHEMISTRY 29(18):4430-4433 KOMORI M; NISHIO K; KITADA M; SHIRAMATSU K; MUROYA K; SOMA M; NAGASHIMA K; KAMATAKI T FETUS-SPECIFIC EXPRESSION OF A FORM OF CYTOCHROME-P-450 IN HUMAN LIVERS	105	68
219	12	7037 1990 DRUG METABOLISM REVIEWS 22(2-3):147-159 YANG CS; YOO JSH; ISHIZAKI H; HONG JY CYTOCHROME-P450IIE1 - ROLES IN NITROSAMINE METABOLISM AND MECHANISMS OF REGULATION	256	68
220	5	526 1966 JOURNAL OF BIOCHEMISTRY 59(6):574-& KATO R POSSIBLE ROLE OF P-450 IN OXIDATION OF DRUGS IN LIVER MICROSOMES	127	67
221	14	1189 1970 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 174(1):218-& ESTABROOK RW; FRANKLIN MR; HILDEBRANDT AG FACTORS INFLUENCING INHIBITORY EFFECT OF CARBON MONOXIDE ON CYTOCHROME P-450-CATALYZED MIXED FUNCTION OXIDATION REACTIONS	67	67
222	7	1805 1972 BIOCHEMICAL PHARMACOLOGY 21(24):3249-& CINTI DL; SCHENKMAN JB; MOLDEUS P KINETIC PARAMETERS OF DRUG-METABOLIZING ENZYMES IN CA2+ - SEDIMENTED MICROSOMES FROM RAT-LIVER	271	67
223	3	2418 1974 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 60(2):695-702 RAHIMTULA AD; OBRIEN PJ; HRYCAY EG; PETERSON JA; ESTABROOK RW POSSIBLE HIGHER VALENCE STATES OF CYTOCHROME-P-450 DURING OXIDATIVE REACTIONS	67	67
224	3	5764 1987 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 258(1):292-297 WRIGHTON SA; THOMAS PE; RYAN DE; LEVIN W PURIFICATION AND CHARACTERIZATION OF ETHANOL-INDUCIBLE HUMAN HEPATIC CYTOCHROME-P-450HLJ1	118	67
225	5	6466 1989 BIOCHEMISTRY 28(18):7340-7348 YAMANO S; NHAMBURO PT; AOYAMA T; MEYER UA; INABA T; KALOW W; GELBOIN HV; MCBRIDE OW; GONZALEZ FJ CDNA CLONING AND SEQUENCE AND CDNA-DIRECTED EXPRESSION OF HUMAN P450-IIB1 - IDENTIFICATION OF A NORMAL AND 2 VARIANT CDNAS DERIVED FROM THE CYP2B LOCUS ON CHROMOSOME-19 AND DIFFERENTIAL EXPRESSION OF THE IIB MESSENGER-RNAS IN HUMAN-LIVER	123	67
226	14	1457 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 147(1):14-& HRYCAY EG; OBRIEN PJ CYTOCHROME P-450 AS A MICROSOMAL PEROXIDASE UTILIZING A LIPID PEROXIDE SUBSTRATE	196	66
227	6	4771 1983 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 114(2):743-749 FALCK JR; MANNA S; MOLTZ J; CHACOS N; CAPDEVILA J EPOXYEICOSATRIENOIC ACIDS STIMULATE GLUCAGON AND INSULIN RELEASE FROM ISOLATED RAT PANCREATIC-ISLETS	100	66
228	6	5949 1987 MOLECULAR ENDOCRINOLOGY 1(8):542-547 SONG BJ; MATSUNAGA T; HARDWICK JP; PARK SS; VEECH RL; YANG CS; GELBOIN HV; GONZALEZ FJ STABILIZATION OF CYTOCHROME-P450J MESSENGER-RIBONUCLEIC-ACID IN THE DIABETIC RAT	163	66
229	6	6282 1988 MOLECULAR PHARMACOLOGY 33(5):493-499 SCHWAB GE; RAUCY JL; JOHNSON EF MODULATION OF RABBIT AND HUMAN HEPATIC CYTOCHROME-P-450- CATALYZED STEROID HYDROXYLATIONS BY ALPHA-NAPHTHOFLAVONE	135	66
230	41	7738 1991 MUTATION RESEARCH 247(1):113-127 GONZALEZ FJ; CRESPI CL; GELBOIN HV CDNA-EXPRESSED HUMAN CYTOCHROME-P450S - A NEW AGE OF MOLECULAR TOXICOLOGY AND HUMAN RISK ASSESSMENT	148	66
231	8	496 1966 BIOCHIMICA ET BIOPHYSICA ACTA 128(1):13-& OSHINO N; IMAI Y; SATO R ELECTRON-TRANSFER MECHANISM ASSOCIATED WITH FATTY ACID DESATURATION CATALYZED BY LIVER MICROSOMES	275	65
232	10	1146 1969 MOLECULAR PHARMACOLOGY 5(4):412-& SHOEMAN DW; CHAPLIN MD; MANNERIN.GJ INDUCTION OF DRUG METABOLISM .3. FURTHER EVIDENCE FOR FORMATION OF A NEW P-450 HEMOPROTEIN AFTER TREATMENT OF RATS WITH 3- METHYLCHOLANTHRENE	87	65
233	15	3888 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(15):7255-7264 LAMBETH JD; SEYBERT DW; KAMIN H IONIC EFFECTS ON ADRENAL STEROIDOGENIC ELECTRON-TRANSPORT - ROLE OF ADRENODOXIN AS AN ELECTRON SHUTTLE	152	65
234	16	5179 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(11):6812-6817 GORSKY LD; KOOP DR; COON MJ ON THE STOICHIOMETRY OF THE OXIDASE AND MONOOXYGENASE REACTIONS CATALYZED BY LIVER MICROSOMAL CYTOCHROME-P-450 - PRODUCTS OF OXYGEN REDUCTION	175	65
235	7	6866 1990 BIOCHEMICAL JOURNAL 267(2):365-371 MILES JS; MCLAREN AW; FORRESTER LM; GLANCEY MJ; LANG MA; WOLF CR IDENTIFICATION OF THE HUMAN LIVER CYTOCHROME-P-450 RESPONSIBLE FOR COUMARIN 7-HYDROXYLASE ACTIVITY	141	65
236	14	8105 1992 FASEB JOURNAL 6(2):745-748 GUENGERICH FP CHARACTERIZATION OF HUMAN CYTOCHROME-P450 ENZYMES	156	65
237	2	15 1957 JOURNAL OF BIOLOGICAL CHEMISTRY 227(2):1093-1108 ESTABROOK RW KINETIC PROPERTIES OF A REDUCED DIPHOSPHO-PYRIDINE NUCLEOTIDE CYTOCHROME-C REDUCTASE FROM HEART MUSCLE	64	64
238	5	418 1965 JOURNAL OF BIOLOGICAL CHEMISTRY 240(3):1427-& LEE YP; LARDY HA INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF RAT	706	64
239	6	1632 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(24):7826-& STROBEL HW; COON MJ EFFECT OF SUPEROXIDE GENERATION AND DISMUTATION ON HYDROXYLATION REACTIONS CATALYZED BY LIVER MICROSOMAL CYTOCHROME P-450	174	64
240	17	2547 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(6):1747-1754 LEVIN W; RYAN D; WEST S; LU AYH PREPARATION OF PARTIALLY PURIFIED, LIPID DEPLETED CYTOCHROME-P- 450 AND REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE- CYTOCHROME-C REDUCTASE FROM RAT-LIVER MICROSOMES	160	64
241	2	5872 1987 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 6(3):189-197 MURAKAMI H; YABUSAKI Y; SAKAKI T; SHIBATA M; OHKAWA H A GENETICALLY ENGINEERED P450 MONOOXYGENASE - CONSTRUCTION OF THE FUNCTIONAL FUSED ENZYME BETWEEN RAT CYTOCHROME-P450C AND NADPH-CYTOCHROME-P450 REDUCTASE	83	64
242	10	6235 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(23):11396-11406 WAXMAN DJ; LEBLANC GA; MORRISSEY JJ; STAUNTON J; LAPENSON DP ADULT MALE-SPECIFIC AND NEONATALLY PROGRAMMED RAT HEPATIC P-450 FORMS RLM2 AND 2A ARE NOT DEPENDENT ON PULSATILE PLASMA GROWTH- HORMONE FOR EXPRESSION	119	64
243	1	202 1963 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 12(5):388-& HOCHSTEIN P; ERNSTER L ADP-ACTIVATED LIPID PEROXIDATION COUPLED TO TPNH OXIDASE SYSTEM OF MICROSOMES	467	63
244	7	1307 1970 FEBS LETTERS 9(1):41-& JEFCOATE CR; HUME R; BOYD GS SEPARATION OF 2 FORMS OF CYTOCHROME-P450 ADRENAL CORTEX MITOCHONDRIA	102	63
245	8	1752 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 152(2):457-& LU AYH; WEST S; SOMOGYI A; CONNEY AH; KUNTZMAN R PREGNENOLONE-16ALPHA-CARBONITRILE - NEW TYPE OF INDUCER OF DRUG-METABOLIZING ENZYMES	214	63
246	80	4441 1981 PHARMACOLOGY & THERAPEUTICS 12(1):43-71 SCHENKMAN JB; SLIGAR SG; CINTI DL SUBSTRATE INTERACTION WITH CYTOCHROME-P-450	134	63
247	7	6228 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(10):4956-4962 UMENO M; SONG BJ; KOZAK C; GELBOIN HV; GONZALEZ FJ THE RAT P450IIE1 GENE - COMPLETE INTRON AND EXON SEQUENCE, CHROMOSOME MAPPING, AND CORRELATION OF DEVELOPMENTAL EXPRESSION WITH SPECIFIC 5' CYTOSINE DEMETHYLATION	126	63
248	3	6349 1989 AMERICAN JOURNAL OF HUMAN GENETICS 45(6):889-904 KIMURA S; UMENO M; SKODA RC; MEYER UA; GONZALEZ FJ THE HUMAN DEBRISOQUINE 4-HYDROXYLASE (CYP2D) LOCUS - SEQUENCE AND IDENTIFICATION OF THE POLYMORPHIC CYP2D6 GENE, A RELATED GENE, AND A PSEUDOGENE	233	63
249	10	6550 1989 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 8(7):517-525 KIMURA S; HARDWICK JP; KOZAK CA; GONZALEZ FJ THE RAT CLOFIBRATE-INDUCIBLE CYP4A SUBFAMILY .2. CDNA SEQUENCE OF IVA3, MAPPING OF THE CYP4A LOCUS TO MOUSE CHROMOSOME-4, AND COORDINATE AND TISSUE-SPECIFIC REGULATION OF THE CYP4A GENES	115	63
250	58	7007 1990 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 25(2):97-153 GUENGERICH FP ENZYMATIC OXIDATION OF XENOBIOTIC CHEMICALS	206	63
251	9	7712 1991 METHODS IN ENZYMOLOGY 206():454-462 ARLOTTO MP; TRANT JM; ESTABROOK RW MEASUREMENT OF STEROID HYDROXYLATION REACTIONS BY HIGH- PERFORMANCE LIQUID-CHROMATOGRAPHY AS INDICATOR OF P450 IDENTITY AND FUNCTION	63	63
252	4	40 1958 JOURNAL OF BIOLOGICAL CHEMISTRY 233(5):1223-1229 CHANCE B KINETICS AND INHIBITION OF CYTOCHROME COMPONENTS OF THE SUCCINIC OXIDASE SYSTEM .3. CYTOCHROME-B	169	62
253	10	320 1964 JOURNAL OF BIOLOGICAL CHEMISTRY 239(6):2042-& MINAKAMI S; ESTABROOK RW; SCHINDLER FJ HYDROGEN TRANSFER BETWEEN REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE DEHYDROGENASE + RESPIRATORY CHAIN .I. EFFECT OF SULFHYDRYL INHIBITORS + PHOSPHOLIPASE	62	62
254	2	634 1967 BIOCHEMISTRY 6(6):1658-& PALMER G; BRINTZIN.H; ESTABROOK RW SPECTROSCOPIC STUDIES ON SPINACH FERREDOXIN AND ADRENODOXIN	62	62
255	3	1822 1972 BIOCHIMICA ET BIOPHYSICA ACTA 263(2):272-& SUHARA K; TAKEMORI S; KATAGIRI M IMPROVED PURIFICATION OF BOVINE ADRENAL IRON-SULFUR PROTEIN	175	62
256	19	4800 1983 BIOCHEMISTRY 22(12):2811-2820 GUENGERICH FP OXIDATION REDUCTION PROPERTIES OF RAT-LIVER CYTOCHROMES-P-450 AND NADPH CYTOCHROME-P-450 REDUCTASE RELATED TO CATALYSIS IN RECONSTITUTED SYSTEMS	105	62
257	28	6542 1989 CRITICAL REVIEWS IN TOXICOLOGY 20(3):153-174 NEBERT DW THE AH LOCUS - GENETIC-DIFFERENCES IN TOXICITY, CANCER, MUTATION, AND BIRTH-DEFECTS	283	62
258	18	7677 1991 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 256(3):1189-1194 GUENGERICH FP; TURVY CG COMPARISON OF LEVELS OF SEVERAL HUMAN MICROSOMAL CYTOCHROME-P- 450 ENZYMES AND EPOXIDE HYDROLASE IN NORMAL AND DISEASE STATES USING IMMUNOCHEMICAL ANALYSIS OF SURGICAL LIVER SAMPLES	196	62
259	9	8991 1994 BIOCHEMISTRY 33(21):6450-6455 SHOU M; GROGAN J; MANCEWICZ JA; KRAUSZ KW; GONZALEZ FJ; GELBOIN HV; KORZEKWA KR ACTIVATION OF CYP3A4 - EVIDENCE FOR THE SIMULTANEOUS BINDING OF 2 SUBSTRATES IN A CYTOCHROME-P450 ACTIVE-SITE	170	62
260	2	38 1958 JOURNAL OF BIOLOGICAL CHEMISTRY 230(2):735-750 ESTABROOK RW SPECTRAL AND ENZYMATIC CHARACTERIZATION OF CYTOCHROME-C1 OF LIVER MITOCHONDRIA	61	61
261	13	600 1967 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 122(3):735-& CAMMER W; ESTABROOK RW SPECTROPHOTOMETRIC STUDIES OF PIGMENTS OF ADRENAL CORTEX MITOCHONDRIA	61	61
262	5	5873 1987 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 6(5):439-448 PICADOLEONARD J; MILLER WL CLONING AND SEQUENCE OF THE HUMAN-GENE FOR P450C17 (STEROID 17- ALPHA-HYDROXYLASE/17,20 LYASE) - SIMILARITY WITH THE GENE FOR P450C21	189	61
263	21	7138 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(19):10865-10871 CAPDEVILA JH; KARARA A; WAXMAN DJ; MARTIN MV; FALCK JR; GUENGUERICH FP CYTOCHROME-P-450 ENZYME-SPECIFIC CONTROL OF THE REGIOFACIAL AND ENANTIOFACIAL SELECTIVITY OF THE MICROSOMAL ARACHIDONIC-ACID EPOXYGENASE	101	61
264	6	925 1968 NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE 259(2):98-& REMMER H; ESTABROOK RW; SCHENKMA.J; GREIM H REACTION OF DRUGS WITH MICROSOMAL LIVER HYDROXYLASE - ITS INFLUENCE ON DRUG ACTION	42	60
265	16	957 1969 ANNUAL REVIEW OF PHARMACOLOGY 9():21-& KUNTZMAN R DRUGS AND ENZYME INDUCTION	293	60
266	20	1433 1971 ANNUAL REVIEW OF PHARMACOLOGY 11():37-& ANDERS MW ENHANCEMENT AND INHIBITION OF DRUG METABOLISM	169	60
267	20	4379 1981 JOURNAL OF BIOLOGICAL CHEMISTRY 256(1):266-277 VERMILION JL; BALLOU DP; MASSEY V; COON MJ SEPARATE ROLES FOR FMN AND FAD IN CATALYSIS BY LIVER MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE	179	60
268	8	6651 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(32):19385-19391 MEANS GD; MAHENDROO MS; CORBIN CJ; MATHIS JM; POWELL FE; MENDELSON CR; SIMPSON ER STRUCTURAL-ANALYSIS OF THE GENE ENCODING HUMAN AROMATASE CYTOCHROME-P-450, THE ENZYME RESPONSIBLE FOR ESTROGEN BIOSYNTHESIS	210	60
269	0	6661 1989 JOURNAL OF CLINICAL INVESTIGATION 84(1):155-161 HALLER RG; LEWIS SF; ESTABROOK RW; DIMAURO S; SERVIDEI S; FOSTER DW EXERCISE INTOLERANCE, LACTIC-ACIDOSIS, AND ABNORMAL CARDIOPULMONARY REGULATION IN EXERCISE ASSOCIATED WITH ADULT SKELETAL-MUSCLE CYTOCHROME-C OXIDASE DEFICIENCY	60	60
270	12	8005 1992 CARCINOGENESIS 13(10):1789-1794 YAMAZAKI H; INUI Y; YUN CH; GUENGERICH FP; SHIMADA T CYTOCHROME P450 2E1 AND 2A6 ENZYMES AS MAJOR CATALYSTS FOR METABOLIC-ACTIVATION OF N-NITROSODIALKYLAMINES AND TOBACCO- RELATED NITROSAMINES IN HUMAN LIVER-MICROSOMES	207	60
271	14	9191 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(18):13092-13099 SUTTER TR; TANG YM; HAYES CL; WO YYP; JABS EW; LI X; YIN H; CODY CW; GREENLEE WF COMPLETE CDNA SEQUENCE OF A HUMAN DIOXIN-INDUCIBLE MESSENGER- RNA IDENTIFIES A NEW GENE SUBFAMILY OF CYTOCHROME-P450 THAT MAPS TO CHROMOSOME-2	218	60
272	17	9321 1994 PHARMACOGENETICS 4(1):11-20 SCHUETZ JD; BEACH DL; GUZELIAN PS SELECTIVE EXPRESSION OF CYTOCHROME-P450 CYP3A MESSENGER-RNAS IN EMBRYONIC AND ADULT HUMAN LIVER	115	60
273	6	1797 1972 BIOCHEMICAL PHARMACOLOGY 21(17):2373-& SCHENKMAN JB; WILSON BJ; CINTI DL DIETHYLAMINOETHYL 2,2-DIPHENYLVALERATE HCL (SKF525-A)-IN-VIVO AND IN-VITRO EFFECTS OF METABOLISM BY RAT-LIVER MICROSOMES FORMATION OF AN OXYGENATED COMPLEX	117	59
274	12	3885 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(13):5695-5700 MIWA GT; WEST SB; HUANG MT; LU AYH STUDIES ON THE ASSOCIATION OF CYTOCHROME-P-450 AND NADPH- CYTOCHROME-C REDUCTASE DURING CATALYSIS IN A RECONSTITUTED HYDROXYLATING SYSTEM	108	59
275	26	3945 1979 PHYSIOLOGICAL REVIEWS 59(3):527-605 CHANCE B; SIES H; BOVERIS A HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS	2497	59
276	11	5815 1987 BIOCHEMISTRY 26(22):7073-7083 SWINNEY DC; RYAN DE; THOMAS PE; LEVIN W REGIOSELECTIVE PROGESTERONE HYDROXYLATION CATALYZED BY 11 RAT HEPATIC CYTOCHROME-P-450 ISOZYMES	113	59
277	13	6458 1989 BIOCHEMISTRY 28(9):3762-3770 EDWARDS RJ; MURRAY BP; BOOBIS AR; DAVIES DS IDENTIFICATION AND LOCATION OF ALPHA-HELICES IN MAMMALIAN CYTOCHROMES-P450	85	59
278	9	6470 1989 BIOCHEMISTRY 28(20):8060-8066 NHAMBURO PT; GONZALEZ FJ; MCBRIDE OW; GELBOIN HV; KIMURA S IDENTIFICATION OF A NEW P450 EXPRESSED IN HUMAN-LUNG - COMPLETE CDNA SEQUENCE, CDNA-DIRECTED EXPRESSION, AND CHROMOSOME MAPPING	96	59
279	6	234 1963 JOURNAL OF BIOLOGICAL CHEMISTRY 238(1):418-& CHANCE B; HOLLUNGER G INHIBITION OF ELECTRON AND ENERGY TRANSFER IN MITOCHONDRIA .1. EFFECTS OF AMYTAL, THIOPENTAL, ROTENONE, PROGESTERONE, AND METHYLENE GLYCOL	245	58
280	12	1936 1972 JOURNAL OF BIOLOGICAL CHEMISTRY 247(18):5777-& TYSON CA; LIPSCOMB JD; GUNSALUS IC ROLES OF PUTIDAREDOXIN AND P450CAM IN METHYLENE HYDROXYLATION	134	58
281	9	2581 1974 LIFE SCIENCES 14(1):35-46 SASAME HA; THORGEIR.SS; MITCHELL JR; GILLETTE JR POSSIBLE INVOLVEMENT OF CYTOCHROME-B5 IN OXIDATION OF LAURIC ACID BY MICROSOMES FROM KIDNEY-CORTEX AND LIVER OF RATS	72	58
282	24	4400 1981 JOURNAL OF BIOLOGICAL CHEMISTRY 256(18):9457-9465 BONFILS C; BALNY C; MAUREL P DIRECT EVIDENCE FOR ELECTRON-TRANSFER FROM FERROUS CYTOCHROME- B5 TO THE OXYFERROUS INTERMEDIATE OF LIVER MICROSOMAL CYTOCHROME-P-450 LM2	88	58
283	5	6113 1988 BIOCHEMISTRY 27(15):5447-5454 ZANGER UM; VILBOIS F; HARDWICK JP; MEYER UA ABSENCE OF HEPATIC CYTOCHROME P450BUFI CAUSES GENETICALLY DEFICIENT DEBRISOQUINE OXIDATION IN MAN	162	58
284	5	6308 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(23):8948-8952 CORBIN CJ; GRAHAMLORENCE S; MCPHAUL M; MASON JI; MENDELSON CR; SIMPSON ER ISOLATION OF A FULL-LENGTH CDNA INSERT ENCODING HUMAN AROMATASE SYSTEM CYTOCHROME-P-450 AND ITS EXPRESSION IN NONSTEROIDOGENIC CELLS	231	58
285	9	6788 1989 XENOBIOTICA 19(10):1093-1110 STEGEMAN JJ CYTOCHROME-P450 FORMS IN FISH - CATALYTIC, IMMUNOLOGICAL AND SEQUENCE SIMILARITIES	149	58
286	10	7731 1991 MOLECULAR PHARMACOLOGY 40(1):69-79 SRIVASTAVA PK; YUN CH; BEAUNE PH; GED C; GUENGERICH FP SEPARATION OF HUMAN LIVER MICROSOMAL TOLBUTAMIDE HYDROXYLASE AND (S)-MEPHENYTOIN 4'-HYDROXYLASE CYTOCHROME-P-450 ENZYMES	112	58
287	13	985 1969 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 36(4):545-& LU AYH; STROBEL HW; COON MJ HYDROXYLATION OF BENZPHETAMINE AND OTHER DRUGS BY A SOLUBILIZED FORM OF CYTOCHROME P-450 FROM LIVER MICROSOMES - LIPID REQUIREMENT FOR DRUG DEMETHYLATION	142	57
288	6	1665 1971 LIFE SCIENCES PT-2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 10(9):503-& PHILPOT RM; HODGSON E CYTOCHROME P-450-PIPERONYL BUTOXIDE SPECTRUM SIMILAR TO THAT PRODUCED BY ETHYL ISOCYANIDE	103	57
289	11	2052 1973 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 212(JUN22):406-419 MASON JI; ESTABROOK RW; PURVIS JL TESTICULAR CYTOCHROME-P-450 AND IRON-SULFUR PROTEIN AS RELATED TO STEROID METABOLISM	57	57
290	9	2323 1973 LIFE SCIENCES 13(10):1319-1330 WERRINGLOER J; ESTABROOK RW EVIDENCE FOR AN INHIBITORY PRODUCT CYTOCHROME-P-450 COMPLEX GENERATED DURING BENZPHETAMINE METABOLISM BY LIVER-MICROSOMES	57	57
291	24	4137 1980 JOURNAL OF BIOLOGICAL CHEMISTRY 255(8):3386-3394 KOMINAMI S; OCHI H; KOBAYASHI Y; TAKEMORI S STUDIES ON THE STEROID HYDROXYLATION SYSTEM IN ADRENAL-CORTEX MICROSOMES - PURIFICATION AND CHARACTERIZATION OF CYTOCHROME-P- 450 SPECIFIC FOR STEROID C-21 HYDROXYLATION	144	57
292	18	4839 1983 CHEMICO-BIOLOGICAL INTERACTIONS 45(2):243-258 BURKE MD; MAYER RT DIFFERENTIAL-EFFECTS OF PHENOBARBITONE AND 3-METHYLCHOLANTHRENE INDUCTION ON THE HEPATIC-MICROSOMAL METABOLISM AND CYTOCHROME P-450-BINDING OF PHENOXAZONE AND A HOMOLOGOUS SERIES OF ITS NORMAL-ALKYL ETHERS (ALKOXYRESORUFINS)	254	57
293	14	5284 1985 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 243(1):8-19 CAPDEVILA J; KIM YR; WIXTROM CM; FALCK JR; MANNA S; ESTABROOK RW INFLUENCE OF A FIBRIC ACID TYPE OF HYPOLIPIDEMIC AGENT ON THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID BY LIVER MICROSOMAL CYTOCHROME-P-450	57	57
294	19	5436 1985 JOURNAL OF BIOLOGICAL CHEMISTRY 260(11):7084-7093 JANSSON I; MOLE J; SCHENKMAN JB PURIFICATION AND CHARACTERIZATION OF A NEW FORM (RLM2) OF LIVER MICROSOMAL CYTOCHROME-P-450 FROM UNTREATED RAT	98	57
295	14	6246 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(34):17995-18002 MATSUNAGA T; NAGATA K; HOLSZTYNSKA EJ; LAPENSON DP; SMITH A; KATO R; GELBOIN HV; WAXMAN DJ; GONZALEZ FJ GENE CONVERSION AND DIFFERENTIAL REGULATION IN THE RAT P-450- IIA GENE SUBFAMILY - PURIFICATION, CATALYTIC ACTIVITY, CDNA AND DEDUCED AMINO-ACID SEQUENCE, AND REGULATION OF AN ADULT MALE- SPECIFIC HEPATIC TESTOSTERONE 15-ALPHA-HYDROXYLAS	88	57
296	4	6653 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(35):20961-20967 MORNET E; DUPONT J; VITEK A; WHITE PC CHARACTERIZATION OF 2 GENES ENCODING HUMAN STEROID 11-BETA- HYDROXYLASE (P-45011-BETA)	243	57
297	1	237 1963 JOURNAL OF BIOLOGICAL CHEMISTRY 238(4):1320-& COOPER DY; ROSENTHAL O; ESTABROOK RW STOICHIOMETRY OF C21 HYDROXYLATION OF STEROIDS BY ADRENOCORTICAL MICROSOMES	56	56
298	11	685 1967 JOURNAL OF BIOCHEMISTRY 62(4):464-& IMAI Y; SATO R ANOMALOUS SPECTRAL INTERACTIONS OF REDUCED P-450 WITH ETHYL ISOCYANIDE AND SOME OTHER LIPOPHILIC LIGANDS	81	56
299	8	915 1968 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 163(2):417-& ALVARES AP; SCHILLIN.G; LEVIN W; KUNTZMAN R ALTERATION OF MICROSOMAL HEMOPROTEIN BY 3-METHYLCHOLANTHRENE - EFFECTS OF ETHIONINE AND ACTINOMYCIN D	91	56
300	4	6755 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(21):8262-8265 KRONBACH T; LARABEE TM; JOHNSON EF HYBRID CYTOCHROME-P-450 IDENTIFY A SUBSTRATE BINDING DOMAIN IN CYTOCHROME-P-450IIC5 AND CYTOCHROME-P-450IIC4	73	56

#	Cited nodes	Nodes / Authors	GCS	LCS
301	17	1467 1971 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42(6):1200-& LU AYH; KUNTZMAN R; WEST S; CONNEY AH RECONSTITUTED LIVER MICROSOMAL ENZYME SYSTEM THAT HYDROXYLATES DRUGS, OTHER FOREIGN COMPOUNDS AND ENDOGENOUS SUBSTRATES .1. DETERMINATION OF SUBSTRATE SPECIFICITY BY CYTOCHROME P-450 AND P-448 FRACTIONS	132	55
302	30	2748 1975 BIOCHIMICA ET BIOPHYSICA ACTA 415(4):411-472 DEPIERRE JW; DALLNER G STRUCTURAL ASPECTS OF MEMBRANE OF ENDOPLASMIC-RETICULUM	379	55
303	10	3641 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(24):8812-8819 VERMILION JL; COON MJ IDENTIFICATION OF THE HIGH AND LOW POTENTIAL FLAVINS OF LIVER MICROSOMAL NADPH-CYTOCHROME P-450 REDUCTASE	170	55
304	14	3891 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(18):8976-8981 ENOCH HG; STRITTMATTER P CYTOCHROME-B5 REDUCTION BY NADPH-CYTOCHROME P-450 REDUCTASE	125	55
305	5	6365 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 268(1):144-151 WRIGHTON SA; VANDENBRANDEN M ISOLATION AND CHARACTERIZATION OF HUMAN-FETAL LIVER CYTOCHROME P450HLP2 - A 3RD MEMBER OF THE P450III GENE FAMILY	72	55
306	4	6537 1989 CLINICAL PHARMACOLOGY & THERAPEUTICS 46(5):521-527 BARGETZI MJ; AOYAMA T; GONZALEZ FJ; MEYER UA LIDOCAINE METABOLISM IN HUMAN-LIVER MICROSOMES BY CYTOCHROME- P450IIIA4	206	55
307	6	6953 1990 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 29(6):651-663 SESARDIC D; BOOBIS AR; MURRAY BP; MURRAY S; SEGURA J; DELATORRE R; DAVIES DS FURAFYLLINE IS A POTENT AND SELECTIVE INHIBITOR OF CYTOCHROME- P450IA2 IN MAN	192	55
308	13	7113 1990 JOURNAL OF BIOCHEMISTRY 107(5):718-725 NAGATA K; GONZALEZ FJ; YAMAZOE Y; KATO R PURIFICATION AND CHARACTERIZATION OF 4 CATALYTICALLY ACTIVE TESTOSTERONE 6-BETA-HYDROXYLASE-P-450S FROM RAT-LIVER MICROSOMES - COMPARISON OF A NOVEL FORM WITH 3 STRUCTURALLY AND FUNCTIONALLY RELATED FORMS	88	55
309	12	8412 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 306(1):240-245 WRIGHTON SA; STEVENS JC; BECKER GW; VANDENBRANDEN M ISOLATION AND CHARACTERIZATION OF HUMAN LIVER CYTOCHROME-P450 2C19 - CORRELATION BETWEEN 2C19 AND S-MEPHENYTOIN-4'- HYDROXYLATION	206	55
310	30	8544 1993 CANCER RESEARCH 53(23):5629-5637 CHANG TKH; WEBER GF; CRESPI CL; WAXMAN DJ DIFFERENTIAL ACTIVATION OF CYCLOPHOSPHAMIDE AND IFOSPHAMIDE BY CYTOCHROME-P-450-2B AND CYTOCHROME-P450-3A IN HUMAN LIVER- MICROSOMES	225	55
311	55	9368 1994 TOXICOLOGY AND APPLIED PHARMACOLOGY 125(2):163-175 HALPERT JR; GUENGERICH FP; BEND JR; CORREIA MA SELECTIVE INHIBITORS OF CYTOCHROMES P450	185	55
312	6	535 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(10):2212-& HARDING BW; NELSON DH ELECTRON CARRIERS OF BOVINE ADRENAL CORTICAL RESPIRATORY CHAIN AND HYDROXYLATING PATHWAYS	68	54
313	16	2953 1976 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 172(2):463-469 MATSUBARA T; BARON J; PETERSON LL; PETERSON JA NADPH-CYTOCHROME P450 REDUCTASE	78	54
314	12	3015 1976 BIOCHIMICA ET BIOPHYSICA ACTA 426(3):399-407 DUPPEL W; ULLRICH V MEMBRANE EFFECTS ON DRUG MONO-OXYGENATION ACTIVITY IN HEPATIC MICROSOMES	101	54
315	16	3132 1976 JOURNAL OF BIOLOGICAL CHEMISTRY 251(15):4659-4665 HUANG MT; WEST SB; LU AYH SEPARATION, PURIFICATION, AND PROPERTIES OF MULTIPLE FORMS OF CYTOCHROME-P-450 FROM LIVER-MICROSOMES OF PHENOBARBITAL-TREATED MICE	181	54
316	9	3725 1979 ACTA BIOLOGICA ET MEDICA GERMANICA 38(2-3):423-434 ESTABROOK RW; KAWANO S; WERRINGLOER J; KUTHAN H; TSUJI H; GRAF H; ULLRICH V OXYCYTOCHROME-P-450 - ITS BREAKDOWN TO SUPEROXIDE FOR THE FORMATION OF HYDROGEN-PEROXIDE	55	54
317	5	5892 1987 EUROPEAN JOURNAL OF PHARMACOLOGY 138(2):281-283 CARROLL MA; SCHWARTZMAN M; CAPDEVILA J; FALCK JR; MCGIFF JC VASOACTIVITY OF ARACHIDONIC-ACID EPOXIDES	106	54
318	12	6790 1989 XENOBIOTICA 19(10):1149-1160 NEBERT DW; NELSON DR; FEYEREISEN R EVOLUTION OF THE CYTOCHROME-P450 GENES	103	54
319	18	7137 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(18):10244-10249 FALCK JR; SUN LM; BLAIR I; DISHMAN E; MARTIN MV; WAXMAN DJ; GUENGERICH FP; CAPDEVILA JH CYTOCHROME-P-450-DEPENDENT OXIDATION OF ARACHIDONIC-ACID TO 16- HYDROXYEICOSATETRAENOIC 17-HYDROXYEICOSATETRAENOIC AND 18- HYDROXYEICOSATETRAENOIC ACIDS	82	54
320	10	7202 1990 JOURNAL OF THE NATIONAL CANCER INSTITUTE 82(16):1333-1339 MCLEMORE TL; ADELBERG S; LIU MC; MCMAHON NA; YU SJ; HUBBARD WC; CZERWINSKI M; WOOD TG; STORENG R; LUBET RA; EGGLESTON JC; BOYD MR; HINES RN EXPRESSION OF CYP1A1 GENE IN PATIENTS WITH LUNG-CANCER - EVIDENCE FOR CIGARETTE SMOKE-INDUCED GENE-EXPRESSION IN NORMAL LUNG-TISSUE AND FOR ALTERED GENE-REGULATION IN PRIMARY PULMONARY CARCINOMAS	204	54
321	28	7879 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 298(1):211-225 PEARCE R; GREENWAY D; PARKINSON A SPECIES-DIFFERENCES AND INTERINDIVIDUAL VARIATION IN LIVER MICROSOMAL CYTOCHROME-P450-2A ENZYMES - EFFECTS ON COUMARIN, DICUMAROL, AND TESTOSTERONE OXIDATION	121	54
322	25	8184 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(30):21720-21726 CAPDEVILA JH; WEI S; YAN J; KARARA A; JACOBSON HR; FALCK JR; GUENGERICH FP; DUBOIS RN CYTOCHROME-P-450 ARACHIDONIC-ACID EPOXYGENASE - REGULATORY CONTROL OF THE RENAL EPOXYGENASE BY DIETARY SALT LOADING	96	54
323	23	8975 1994 BIOCHEMICAL PHARMACOLOGY 48(5):923-936 BURKE MD; THOMPSON S; WEAVER RJ; WOLF CR; MAYER RT CYTOCHROME-P450 SPECIFICITIES OF ALKOXYRESORUFIN O-DEALKYLATION IN HUMAN AND RAT-LIVER	194	54
324	25	1455 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 145(2):531-& PETERSON JA; ULLRICH V; HILDEBRANDT AG METYRAPONE INTERACTION WITH PSEUDOMONAS-PUTIDA CYTOCHEROME P- 450	95	53
325	14	5542 1986 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 248(1):158-165 LEVIN W; THOMAS PE; OLDFIELD N; RYAN DE N-DEMETHYLATION OF N-NITROSODIMETHYLAMINE CATALYZED BY PURIFIED RAT HEPATIC-MICROSOMAL CYTOCHROME-P-450 - ISOZYME SPECIFICITY AND ROLE OF CYTOCHROME-B5	118	53
326	7	5830 1987 BIOCHIMICA ET BIOPHYSICA ACTA 926(3):349-358 FUNAE Y; IMAOKA S PURIFICATION AND CHARACTERIZATION OF LIVER MICROSOMAL CYTOCHROME-P-450 FROM UNTREATED MALE-RATS	114	53
327	7	6743 1989 PHARMACOLOGY & THERAPEUTICS 43(1):53-76 WILKINSON GR; GUENGERICH FP; BRANCH RA GENETIC-POLYMORPHISM OF S-MEPHENYTOIN HYDROXYLATION	216	53
328	29	9432 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 317(2):374-384 GILLAM EMJ; GUO ZY; UENG YF; YAMAZAKI H; COCK I; REILLY PEB; HOOPER WD; GUENGERICH FP EXPRESSION OF CYTOCHROME-P450-3A5 IN ESCHERICHIA-COLI - EFFECTS OF 5' MODIFICATION, PURIFICATION, SPECTRAL CHARACTERIZATION, RECONSTITUTION CONDITIONS, AND CATALYTIC ACTIVITIES	88	53
329	17	2839 1975 JOURNAL OF BIOCHEMISTRY 78(3):455-468 YOSHIDA Y; KUMAOKA H STUDIES ON SUBSTRATE-INDUCED SPECTRAL CHANGE OF CYTOCHROME-P- 450 IN LIVER-MICROSOMES	79	52
330	21	3626 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(6):1921-1929 MIWA GT; WEST SB; LU AYH STUDIES ON RATE-LIMITING ENZYME COMPONENT IN MICROSOMAL MONO- OXYGENASE SYSTEM - INCORPORATION OF PURIFIED NADPH-CYTOCHROME-C REDUCTASE AND CYTOCHROME-P-450 INTO RAT-LIVER MICROSOMES	124	52
331	27	4124 1980 JOURNAL OF BIOCHEMISTRY 87(5):1457-1467 SUGIYAMA T; MIKI N; YAMANO T NADH-DEPENDENT AND NADPH-DEPENDENT RECONSTITUTED PARA- NITROANISOLE O-DEMETHYLATION SYSTEM CONTAINING CYTOCHROME-P-450 WITH HIGH-AFFINITY FOR CYTOCHROME-B5	86	52
332	98	6295 1988 PHARMACOLOGICAL REVIEWS 40(4):243-288 GONZALEZ FJ THE MOLECULAR-BIOLOGY OF CYTOCHROME P450S	106	52
333	5	6382 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 271(2):270-283 RAUCY JL; LASKER JM; LIEBER CS; BLACK M ACETAMINOPHEN ACTIVATION BY HUMAN-LIVER CYTOCHROMES P450IIE1 AND P450IA2	252	52
334	8	6465 1989 BIOCHEMISTRY 28(17):6848-6857 FURUYA H; SHIMIZU T; HIRANO K; HATANO M; FUJIIKURIYAMA Y; RAAG R; POULOS TL SITE-DIRECTED MUTAGENESES OF RAT-LIVER CYTOCHROME-P-450D - CATALYTIC ACTIVITIES TOWARD BENZPHETAMINE AND 7-ETHOXYCOUMARIN	87	52
335	2	7253 1990 NATURE 347(6295):773-776 GOUGH AC; MILES JS; SPURR NK; MOSS JE; GAEDIGK A; EICHELBAUM M; WOLF CR IDENTIFICATION OF THE PRIMARY GENE DEFECT AT THE CYTOCHROME- P450 CYP2D LOCUS	221	52
336	11	7279 1990 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87(15):5893-5897 CATELLA F; LAWSON JA; FITZGERALD DJ; FITZGERALD GA ENDOGENOUS BIOSYNTHESIS OF ARACHIDONIC-ACID EPOXIDES IN HUMANS - INCREASED FORMATION IN PREGNANCY-INDUCED HYPERTENSION	87	52
337	24	9511 1995 BIOCHEMISTRY 34(26):8380-8389 YAMAZAKI H; UENG YF; SHIMADA T; GUENGERICH FP ROLES OF DIVALENT METAL-IONS IN OXIDATIONS CATALYZED BY RECOMBINANT CYTOCHROME-P450 3A4 AND REPLACEMENT OF NADPH- CYTOCHROME P450 REDUCTASE WITH OTHER FLAVOPROTEINS, FERREDOXIN, AND OXYGEN SURROGATES	69	52
338	8	987 1969 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 36(5):789-& LEIBMAN KC; HILDEBRANDT AG; ESTABROOK RW SPECTROPHOTOMETRIC STUDIES OF INTERACTIONS BETWEEN VARIOUS SUBSTRATES IN THEIR BINDING TO MICROSOMAL CYTOCHROME P-450	51	51
339	5	1144 1969 MOLECULAR PHARMACOLOGY 5(2):131-& GUARINO AM; GRAM TE; GIGON PL; GREENE FE; GILLETTE JR CHANGES IN MICHAELIS AND SPECTRAL CONSTANTS FOR ANILINE IN HEPATIC MICROSOMES FROM PHENOBARBITAL-TREATED RATS	107	51
340	23	1981 1972 MOLECULAR PHARMACOLOGY 8(6):667-& GOUJON FM; GIELEN JE; NEBERT DW GENETIC EXPRESSION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION .4. INTERACTION OF VARIOUS COMPOUNDS WITH DIFFERENT FORMS OF CYTOCHROME-P-450 AND EFFECT ON BENZO[A]PYRENE METABOLISM IN- VITRO	192	51
341	61	3668 1978 PHARMACOLOGY & THERAPEUTICS PART A-CHEMOTHERAPY TOXICOLOGY AND METABOLIC INHIBITORS 2(2):337-358 LU AYH; WEST SB RECONSTITUTED MAMMALIAN MIXED-FUNCTION OXIDASES - REQUIREMENTS, SPECIFICITIES AND OTHER PROPERTIES	147	51
342	7	4831 1983 CANCER RESEARCH 43(2):623-629 TU YY; YANG CS HIGH-AFFINITY NITROSAMINE DEALKYLASE SYSTEM IN RAT-LIVER MICROSOMES AND ITS INDUCTION BY FASTING	181	51
343	8	5060 1984 BIOCHEMICAL PHARMACOLOGY 33(13):2071-2081 PARK SS; FUJINO T; MILLER H; GUENGERICH FP; GELBOIN HV MONOCLONAL-ANTIBODIES TO PHENOBARBITAL-INDUCED RAT-LIVER CYTOCHROME-P-450	134	51
344	10	5310 1985 BIOCHEMICAL PHARMACOLOGY 34(18):3221-3229 BAINS SK; GARDINER SM; MANNWEILER K; GILLETT D; GIBSON GG IMMUNOCHEMICAL STUDY ON THE CONTRIBUTION OF HYPOLIPIDEMIC- INDUCED CYTOCHROME-P-452 TO THE METABOLISM OF LAURIC ACID AND ARACHIDONIC-ACID	88	51
345	25	7351 1991 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 31():177-203 FULCO AJ P450BM-3 AND OTHER INDUCIBLE BACTERIAL P450 CYTOCHROMES - BIOCHEMISTRY AND REGULATION	94	51
346	19	8618 1993 EUROPEAN JOURNAL OF BIOCHEMISTRY 218(2):585-595 HASHIMOTO H; TOIDE K; KITAMURA R; FUJITA M; TAGAWA S; ITOH S; KAMATAKI T GENE STRUCTURE OF CYP3A4, AN ADULT-SPECIFIC FORM OF CYTOCHROME- P450 IN HUMAN LIVERS, AND ITS TRANSCRIPTIONAL CONTROL	102	51
347	5	546 1966 JOURNAL OF CELL BIOLOGY 30(1):97-& DALLNER G; SIEKEVIT.P; PALADE GE BIOGENESIS OF ENDOPLASMIC RETICULUM MEMBRANES .2. SYNTHESIS OF CONSTITUTIVE MICROSOMAL ENZYMES IN DEVELOPING RAT HEPATOCYTE	635	50
348	7	900 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(21):5788-& MIYAKE Y; GAYLOR JL; MASON HS PROPERTIES OF A SUBMICROSOMAL PARTICLE CONTAINING P-450 AND FLAVOPROTEIN	83	50
349	18	1104 1969 JOURNAL OF BIOCHEMISTRY 66(2):139-& MITANI F; HORIE S STUDIES ON P-450 .6. SPIN STATE OF P-450 SOLUBILIZED FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	65	50
350	4	1143 1969 MOLECULAR PHARMACOLOGY 5(2):123-& SASAME HA; GILLETTE JR STUDIES ON RELATIONSHIP BETWEEN EFFECTS OF VARIOUS SUBSTANCES ON ABSORPTION SPECTRUM OF CYTOCHROME P-450 AND REDUCTION OF P- NITROBENZOATE BY MOUSE LIVER MICROSOMES	76	50
351	9	1233 1970 BIOCHEMICAL PHARMACOLOGY 19(5):1649-& KATO R; ONODA K STUDIES ON REGULATION OF ACTIVITY OF DRUG OXIDATION IN RAT LIVER MICROSOMES BY ANDROGEN AND ESTROGEN	120	50
352	5	1892 1972 FEBS LETTERS 28(1):45-& SUHARA K; TAKEMORI S; IKEDA Y; KATAGIRI M PURIFICATION AND PROPERTIES OF NADPH-ADRENODOXIN REDUCTASE FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	90	50
353	16	2855 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(18):7405-7414 GUENGERICH FP; BALLOU DP; COON MJ PURIFIED LIVER MICROSOMAL CYTOCHROME-P-450 - ELECTRON-ACCEPTING PROPERTIES AND OXIDATION-REDUCTION POTENTIAL	98	50
354	18	3065 1976 DRUG METABOLISM AND DISPOSITION 4(3):244-255 BUENING MK; FRANKLIN MR SKF 525-A INHIBITION, INDUCTION, AND 452-NM COMPLEX-FORMATION	118	50
355	39	4250 1981 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 21():431-462 NEBERT DW; EISEN HJ; NEGISHI M; LANG MA; HJELMELAND LM; OKEY AB GENETIC MECHANISMS CONTROLLING THE INDUCTION OF POLYSUBSTRATE MONO-OXYGENASE (P-450) ACTIVITIES	282	50
356	17	4750 1983 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 23():481-503 DEMONTELLANO PRO; CORREIA MA SUICIDAL DESTRUCTION OF CYTOCHROME-P-450 DURING OXIDATIVE DRUG- METABOLISM	235	50
357	6	5286 1985 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 243(2):480-491 MENDELSON CR; WRIGHT EE; EVANS CT; PORTER JC; SIMPSON ER PREPARATION AND CHARACTERIZATION OF POLYCLONAL AND MONOCLONAL- ANTIBODIES AGAINST HUMAN AROMATASE CYTOCHROME-P-450 (P- 450AROM), AND THEIR USE IN ITS PURIFICATION	148	50
358	5	5874 1987 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 6(6):529-537 KALB VF; WOODS CW; TURI TG; DEY CR; SUTTER TR; LOPER JC PRIMARY STRUCTURE OF THE P450 LANOSTEROL DEMETHYLASE GENE FROM SACCHAROMYCES-CEREVISIAE	131	50
359	8	6549 1989 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 8(7):503-516 KIMURA S; HANIOKA N; MATSUNAGA E; GONZALEZ FJ THE RAT CLOFIBRATE-INDUCIBLE CYP4A GENE SUBFAMILY .1. COMPLETE INTRON AND EXON SEQUENCE OF THE CYP4A1 AND CYP4A2 GENES, UNIQUE EXON ORGANIZATION, AND IDENTIFICATION OF A CONSERVED 19-BP UPSTREAM ELEMENT	91	50
360	4	6593 1989 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 36(6):537-547 BROSEN K; GRAM LF CLINICAL-SIGNIFICANCE OF THE SPARTEINE-DEBRISOQUINE OXIDATION POLYMORPHISM	288	50
361	11	6998 1990 CLINICAL PHARMACOKINETICS 18(3):220-239 BROSEN K RECENT DEVELOPMENTS IN HEPATIC DRUG OXIDATION - IMPLICATIONS FOR CLINICAL PHARMACOKINETICS	179	50
362	62	7036 1990 DRUG METABOLISM REVIEWS 22(1):1-85 IOANNIDES C; PARKE DV THE CYTOCHROME-P450-I GENE FAMILY OF MICROSOMAL HEMOPROTEINS AND THEIR ROLE IN THE METABOLIC-ACTIVATION OF CHEMICALS	170	50
363	22	8199 1992 JOURNAL OF CLINICAL INVESTIGATION 90(5):1871-1878 KOLARS JC; SCHMIEDLINREN P; SCHUETZ JD; FANG C; WATKINS PB IDENTIFICATION OF RIFAMPIN-INDUCIBLE P450IIIA4 (CYP3A4) IN HUMAN SMALL-BOWEL ENTEROCYTES	276	50
364	29	8299 1992 PHARMACOLOGY & THERAPEUTICS 54(1):17-61 GUENGERICH FP METABOLIC-ACTIVATION OF CARCINOGENS	160	50
365	21	8413 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 306(2):443-450 SANDHU P; BABA T; GUENGERICH FP EXPRESSION OF MODIFIED CYTOCHROME-P450-2C10-(2C9) IN ESCHERICHIA-COLI, PURIFICATION, AND RECONSTITUTION OF CATALYTIC ACTIVITY	73	50
366	71	9415 1995 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 35():369-390 GONZALEZ FJ; KORZEKWA KR CYTOCHROMES P450 EXPRESSION SYSTEMS	82	50
367	14	1734 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 149(1):197-& PETERSON JA; ISHIMURA Y; GRIFFIN BW PSEUDOMONAS-PUTIDA CYTOCHROME-P-450 - CHARACTERIZATION OF AN OXYGENATED FORM OF HEMOPROTEIN	90	49
368	13	1973 1972 MOLECULAR PHARMACOLOGY 8(2):178-& SCHENKMAN JB EFFECTS OF TEMPERATURE AND SUBSTRATES ON COMPONENT REACTIONS OF HEPATIC MICROSOMAL MIXED-FUNCTION OXIDASE	72	49
369	20	3619 1978 JOURNAL OF BIOCHEMISTRY 83(1):61-77 NOSHIRO M; OMURA T IMMUNOCHEMICAL STUDY ON ELECTRON PATHWAY FROM NADH TO CYTOCHROME-P-450 OF LIVER-MICROSOMES	150	49
370	4	4972 1983 MOLECULAR PHARMACOLOGY 24(1):146-155 KAMATAKI T; MAEDA K; YAMAZOE Y; MATSUDA N; ISHII K; KATO R A HIGH-SPIN FORM OF CYTOCHROME-P-450 HIGHLY PURIFIED FROM POLYCHLORINATED BIPHENYL-TREATED RATS - CATALYTIC CHARACTERIZATION AND IMMUNOCHEMICAL QUANTITATION IN LIVER- MICROSOMES	168	49
371	8	6150 1988 CARCINOGENESIS 9(9):1599-1605 HINES RN; MATHIS JM; JACOB CS IDENTIFICATION OF MULTIPLE REGULATORY ELEMENTS ON THE HUMAN CYTOCHROME P450IA1 GENE	131	49
372	5	6286 1988 MOLECULAR PHARMACOLOGY 34(5):628-637 NAMKUNG MJ; YANG HL; HULLA JE; JUCHAU MR ON THE SUBSTRATE-SPECIFICITY OF CYTOCHROME P450IIIA1	145	49
373	4	6305 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(16):5769-5773 DOEHMER J; DOGRA S; FRIEDBERG T; MONIER S; ADESNIK M; GLATT H; OESCH F STABLE EXPRESSION OF RAT CYTOCHROME P-450IIB1 CDNA IN CHINESE- HAMSTER CELLS (V79) AND METABOLIC-ACTIVATION OF AFLATOXIN-B1	153	49
374	7	6703 1989 MOLECULAR ENDOCRINOLOGY 3(6):968-975 FEVOLD HR; LORENCE MC; MCCARTHY JL; TRANT JM; KAGIMOTO M; WATERMAN MR; MASON JI RAT P45017-ALPHA FROM TESTIS - CHARACTERIZATION OF A FULL- LENGTH CDNA-ENCODING A UNIQUE STEROID HYDROXYLASE CAPABLE OF CATALYZING BOTH DELTA-4- AND DELTA-5-STEROID-17,20-LYASE REACTIONS	100	49
375	16	6820 1990 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 30():251-277 WHITLOCK JP GENETIC AND MOLECULAR ASPECTS OF 2,3,7,8-TETRACHLORODIBENZO-P- DIOXIN ACTION	367	49
376	8	7275 1990 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87(10):3904-3908 BOZAK KR; YU H; SIREVAG R; CHRISTOFFERSEN RE SEQUENCE-ANALYSIS OF RIPENING-RELATED CYTOCHROME-P-450 CDNAS FROM AVOCADO FRUIT	95	49
377	28	7844 1992 AQUATIC TOXICOLOGY 22(4):287-311 GOKSOYR A; FORLIN L THE CYTOCHROME-P-450 SYSTEM IN FISH, AQUATIC TOXICOLOGY AND ENVIRONMENTAL MONITORING	273	49
378	6	8460 1993 BIOCHEMICAL PHARMACOLOGY 45(6):1211-1214 BROSEN K; SKJELBO E; RASMUSSEN BB; POULSEN HE; LOFT S FLUVOXAMINE IS A POTENT INHIBITOR OF CYTOCHROME-P4501A2	274	49
379	19	9206 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(44):27401-27408 JENKINS CM; WATERMAN MR FLAVODOXIN AND NADPH-FLAVODOXIN REDUCTASE FROM ESCHERICHIA-COLI SUPPORT BOVINE CYTOCHROME P450C17 HYDROXYLASE-ACTIVITIES	78	49
380	2	338 1964 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 51(6):989-& HIGGINS J CHEMICAL MECHANISM FOR OSCILLATION OF GLYCOLYTIC INTERMEDIATES IN YEAST CELLS	138	48
381	5	361 1965 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 109(3):585-& BETZ A; CHANCE B PHASE RELATIONSHIP OF GLYCOLYTIC INTERMEDIATES IN YEAST CELLS WITH OSCILLATORY METABOLIC CONTROL	156	48
382	0	366 1965 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 19(4):551-& TYLER DD; BUTOW RA; GONZE J; ESTABROOK RW EVIDENCE FOR EXISTENCE AND FUNCTION OF AN OCCULT HIGHLY REACTIVE SULPHYDRYL GROUP IN RESPIRATORY CHAIN DPNH DEHYDROGENASE	48	48
383	2	470 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 23(3):264-& CAMMER W; SCHENKMAN JB; ESTABROOK RW EPR MEASUREMENTS OF SUBSTRATE INTERACTION WITH CYTOCHROME P-450	48	48
384	8	2291 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(14):5183-5187 CHU JW; KIMURA T STUDIES ON ADRENAL STEROID HYDROXYLASES - COMPLEX-FORMATION OF HYDROXYLASE COMPONENTS	113	48
385	21	2497 1974 DRUG METABOLISM AND DISPOSITION 2(3):301-308 MAILMAN RB; KULKARNI AP; BAKER RC; HODGSON E CYTOCHROME-P-450 DIFFERENCE SPECTRA - EFFECT OF CHEMICAL- STRUCTURE ON TYPE-II SPECTRA IN MOUSE HEPATIC MICROSOMES	70	48
386	8	5975 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(22):8125-8129 SCHWARTZMAN ML; BALAZY M; MASFERRER J; ABRAHAM NG; MCGIFF JC; MURPHY RC 12(R)-HYDROXYICOSATETRAENOIC ACID - A CYTOCHROME-P450-DEPENDENT ARACHIDONATE METABOLITE THAT INHIBITS NA+,K+-ATPASE IN THE CORNEA	166	48
387	9	6508 1989 CANCER RESEARCH 49(9):2344-2350 CLARKE L; WAXMAN DJ OXIDATIVE-METABOLISM OF CYCLOPHOSPHAMIDE - IDENTIFICATION OF THE HEPATIC MONOOXYGENASE CATALYSTS OF DRUG ACTIVATION	135	48
388	15	6789 1989 XENOBIOTICA 19(10):1123-1148 GIBSON GG COMPARATIVE ASPECTS OF THE MAMMALIAN CYTOCHROME-P450 IV-GENE FAMILY	93	48
389	13	7216 1990 METHODS IN ENZYMOLOGY 187():385-394 CAPDEVILA JH; FALCK JR; DISHMAN E; KARARA A CYTOCHROME-P-450 ARACHIDONATE OXYGENASE	63	48
390	13	7371 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 290(2):376-380 WADA A; MATHEW PA; BARNES HJ; SANDERS D; ESTABROOK RW; WATERMAN MR EXPRESSION OF FUNCTIONAL BOVINE CHOLESTEROL SIDE-CHAIN CLEAVAGE CYTOCHROME-P450 (P450SCC) IN ESCHERICHIA-COLI	48	48
391	15	7760 1991 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88(10):4558-4562 BRADFIELD JY; LEE YH; KEELEY LL CYTOCHROME-P450 FAMILY-4 IN A COCKROACH - MOLECULAR-CLONING AND REGULATION BY HYPERTREHALOSEMIC HORMONE	69	48
392	5	7938 1992 BIOCHEMISTRY 31(29):6627-6631 WHITE KA; MARLETTA MA NITRIC-OXIDE SYNTHASE IS A CYTOCHROME-P-450 TYPE HEMOPROTEIN	431	48
393	22	8688 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(17):12912-12918 LAETHEM RM; BALAZY M; FALCK JR; LAETHEM CL; KOOP DR FORMATION OF 19(S)-HYDROXYEICOSATETRAENOIC, 19(R)- HYDROXYEICOSATETRAENOIC, AND 18(R)-HYDROXYEICOSATETRAENOIC ACIDS BY ALCOHOL-INDUCIBLE CYTOCHROME-P450 2E1	88	48
394	11	8912 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 310(1):187-195 BERNDTSON AK; CHEN TT 2 UNIQUE CYP1 GENES ARE EXPRESSED IN RESPONSE TO 3- METHYLCHOLANTHRENE TREATMENT IN RAINBOW-TROUT	93	48
395	24	9329 1994 PHARMACOGENETICS 4(5):247-259 KOLARS JC; LOWN KS; SCHMIEDLINREN P; GHOSH M; FANG C; WRIGHTON SA; MERION RM; WATKINS PB CYP3A GENE-EXPRESSION IN HUMAN GUT EPITHELIUM	173	48
396	2	51 1959 BIOCHEMISCHE ZEITSCHRIFT 331(4):254-272 ZEBE E; DELBRUCK A; BUCHER T UBER DEN GLYCERIN-1-P-CYCLUS IM FLUGMUSKEL VON LOCUSTA MIGRATORIA	144	47
397	8	835 1968 EUROPEAN JOURNAL OF BIOCHEMISTRY 4(4):519-& DAS ML; ORRENIUS S; ERNSTER L ON FATTY ACID AND HYDROCARBON HYDROXYLATION IN RAT LIVER MICROSOMES	100	47
398	11	1152 1969 NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE 265(3):205-& NETTER KJ; KAHL GF; MAGNUSSE.MP KINETIC EXPERIMENTS ON BINDING OF METYRAPONE TO LIVER MICROSOMES	71	47
399	8	1314 1970 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 351(8):903-& FROMMER U; ULLRICH V; STAUDING.H HYDROXYLATION OF ALIPHATIC COMPOUNDS BY LIVER MICROSOMES .1. DISTRIBUTION PATTERN OF ISOMERIC ALCOHOLS	119	47
400	28	2508 1974 DRUG METABOLISM REVIEWS 3(2):231-301 HODGSON E; PHILPOT RM INTERACTION OF METHYLENEDIOXYPHENYL (1,3-BENZODIOXOLE) COMPOUNDS WITH ENZYMES AND THEIR EFFECTS ON MAMMALS	136	47

#	Cited nodes	Nodes / Authors	GCS	LCS
401	8	2681 1975 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 62(2):268-275 RAHIMTULA AD; OBRIEN PJ HYDROPEROXIDE DEPENDENT O-DEALKYLATION REACTIONS CATALYZED BY LIVER MICROSOMAL CYTOCHROME-P450	97	47
402	34	3241 1977 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 178(1):89-107 JANSSON I; SCHENKMAN JB STUDIES ON 3 MICROSOMAL ELECTRON-TRANSFER ENZYME-SYSTEMS .2. SPECIFICITY OF ELECTRON FLOW PATHWAYS	90	47
403	6	6467 1989 BIOCHEMISTRY 28(18):7349-7355 MATSUNAGA E; ZANGER UM; HARDWICK JP; GELBOIN HV; MEYER UA; GONZALEZ FJ THE CYP2D GENE SUBFAMILY - ANALYSIS OF THE MOLECULAR-BASIS OF THE DEBRISOQUINE 4-HYDROXYLASE DEFICIENCY IN DA RATS	97	47
404	3	7070 1990 FEBS LETTERS 263(1):131-133 KAWAJIRI K; NAKACHI K; IMAI K; YOSHII A; SHINODA N; WATANABE J IDENTIFICATION OF GENETICALLY HIGH-RISK INDIVIDUALS TO LUNG- CANCER BY DNA POLYMORPHISMS OF THE CYTOCHROME-P450IA1 GENE	282	47
405	17	7643 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(33):22515-22521 KEDZIE KM; BALFOUR CA; ESCOBAR GY; GRIMM SW; HE YA; PEPPERL DJ; REGAN JW; STEVENS JC; HALPERT JR MOLECULAR-BASIS FOR A FUNCTIONALLY UNIQUE CYTOCHROME-P450IIB1 VARIANT	89	47
406	23	8098 1992 FASEB JOURNAL 6(2):669-673 COON MJ; DING XX; PERNECKY SJ; VAZ ADN CYTOCHROME-P450 - PROGRESS AND PREDICTIONS	110	47
407	9	8168 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(15):10375-10380 BODDUPALLI SS; OSTER T; ESTABROOK RW; PETERSON JA RECONSTITUTION OF THE FATTY-ACID HYDROXYLATION FUNCTION OF CYTOCHROME-P-450BM-3 UTILIZING ITS INDIVIDUAL RECOMBINANT HEMOPROTEIN AND FLAVOPROTEIN DOMAINS	47	47
408	36	268 1964 ANNUAL REVIEW OF BIOCHEMISTRY 33():729-& ERNSTER L; LEE CP BIOLOGICAL OXIDOREDUCTIONS	233	46
409	3	387 1965 BIOCHIMICA ET BIOPHYSICA ACTA 99(2):391-& WILSON LD; NELSON DH; HARDING BW A MITOCHONDRIAL ELECTRON CARRIER INVOLVED IN STEROID HYDROXYLATIONS	59	46
410	5	606 1967 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 28(6):945-& SIMPSON ER; BOYD GS PARTIAL RESOLUTION OF MIXED-FUNCTION OXIDASE INVOLVED IN CHOLESTEROL SIDE-CHAIN CLEAVAGE REACTION IN BOVINE ADRENAL MITOCHONDIRA	71	46
411	4	1577 1971 EUROPEAN JOURNAL OF BIOCHEMISTRY 19(4):546-& BRDICZKA D; PETTE D INTRA-MITOCHONDRIAL AND EXTRAMITOCHONDRIAL ISOZYMES OF (NADP) MALATE DEHYDROGENASE	98	46
412	16	1740 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 150(1):105-& BARON J; TAYLOR WE; MASTERS BSS IMMUNOCHEMICAL STUDIES ON ELECTRON-TRANSPORT CHAINS INVOLVING CYTOCHROME-P-450 - ROLE OF IRON-SULFUR PROTEIN, ADRENODOXIN, IN MIXED-FUNCTION OXIDATION REACTIONS	53	46
413	26	2278 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(2):456-460 LU AYH; LEVIN W; WEST SB; JACOBSON M; RYAN D; KUNTZMAN R; CONNEY AH RECONSTITUTED LIVER MICROSOMAL ENZYME-SYSTEM THAT HYDROXYLATES DRUGS, OTHER FOREIGN COMPOUNDS, AND ENDOGENOUS SUBSTRATES .6. DIFFERENT SUBSTRATE SPECIFICITIES OF CYTOCHROME-P-450 FRACTIONS FROM CONTROL AND PHENOBARBITAL-TREATED RATS	132	46
414	3	2811 1975 FEBS LETTERS 54(1):61-64 YANG CS ASSOCIATION BETWEEN CYTOCHROME-P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE IN MICROSOMAL MEMBRANE	59	46
415	6	3010 1976 BIOCHEMISTRY 15(14):3082-3090 HIWATASHI A; ICHIKAWA Y; MARUYA N; YAMANO T; AKI K PROPERTIES OF CRYSTALLINE REDUCED NICOTINAMIDE ADENINE- DINUCLEOTIDE PHOSPHATE-ADRENODOXIN REDUCTASE FROM BOVINE ADRENOCORTICAL MITOCHONDRIA .1. PHYSICOCHEMICAL PROPERTIES OF HOLO-NADPH-ADRENODOXIN AND APO-NADPH-ADRENODOXIN REDUCTASE AND INTERACTION BETWEEN NON-HEME IRON PROTEINS AND REDUCTASE	121	46
416	11	3537 1978 BIOCHEMISTRY 17(17):3633-3639 GUENGERICH FP DESTRUCTION OF HEME AND HEMOPROTEINS MEDIATED BY LIVER MICROSOMAL REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE- CYTOCHROME P-450 REDUCTASE	127	46
417	20	3890 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(18):8895-8902 OPRIAN DD; VATSIS KP; COON MJ KINETICS OF REDUCTION OF CYTOCHROME-P-450LM4 IN A RECONSTITUTED LIVER MICROSOMAL-ENZYME SYSTEM	65	46
418	6	5721 1986 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83(12):4243-4247 CHUNG BC; MATTESON KJ; MILLER WL STRUCTURE OF A BOVINE GENE FOR P-450C21 (STEROID 21- HYDROXYLASE) DEFINES A NOVEL CYTOCHROME-P-450 GENE FAMILY	107	46
419	1	5961 1987 NUCLEIC ACIDS RESEARCH 15(23):10053-10054 KIMURA S; PASTEWKA J; GELBOIN HV; GONZALEZ FJ CDNA AND AMINO-ACID-SEQUENCES OF 2 MEMBERS OF THE HUMAN P450IIC GENE SUBFAMILY	75	46
420	2	5974 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(20):7193-7197 CHUA SC; SZABO P; VITEK A; GRZESCHIK KH; JOHN M; WHITE PC CLONING OF CDNA-ENCODING STEROID 11-BETA-HYDROXYLASE (P450C11)	161	46
421	4	6307 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(21):8256-8260 ZANGER UM; HAURI HP; LOEPER J; HOMBERG JC; MEYER UA ANTIBODIES AGAINST HUMAN CYTOCHROME-P-450DB1 IN AUTOIMMUNE HEPATITIS TYPE-II	173	46
422	13	6914 1990 BIOCHEMISTRY 29(23):5491-5499 NHAMBURO PT; KIMURA S; MCBRIDE OW; KOZAK CA; GELBOIN HV; GONZALEZ FJ THE HUMAN CYP2F GENE SUBFAMILY - IDENTIFICATION OF A CDNA- ENCODING A NEW CYTOCHROME-P450, CDNA-DIRECTED EXPRESSION, AND CHROMOSOME MAPPING	75	46
423	4	7206 1990 LANCET 336(8714):529-532 HEIM M; MEYER UA GENOTYPING OF POOR METABOLIZERS OF DEBRISOQUINE BY ALLELE- SPECIFIC PCR AMPLIFICATION	384	46
424	4	7629 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(18):11909-11914 LI HY; DARWISH K; POULOS TL CHARACTERIZATION OF RECOMBINANT BACILLUS-MEGATERIUM CYTOCHROME- P-450BM-3 AND ITS 2 FUNCTIONAL DOMAINS	62	46
425	14	8186 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(32):22877-22882 WADA A; WATERMAN MR IDENTIFICATION BY SITE-DIRECTED MUTAGENESIS OF 2 LYSINE RESIDUES IN CHOLESTEROL SIDE-CHAIN CLEAVAGE CYTOCHROME-P450 THAT ARE ESSENTIAL FOR ADRENODOXIN BINDING	82	46
426	20	8697 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(26):19681-19689 IMAI T; GLOBERMAN H; GERTNER JM; KAGAWA N; WATERMAN MR EXPRESSION AND PURIFICATION OF FUNCTIONAL HUMAN 17-ALPHA- HYDROXYLASE/17,20-LYASE (P450C17) IN ESCHERICHIA-COLI - USE OF THIS SYSTEM FOR STUDY OF A NOVEL FORM OF COMBINED 17-ALPHA- HYDROXYLASE/17,20-LYASE DEFICIENCY	96	46
427	28	8920 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 311(2):437-442 CHANG TKH; GONZALEZ FJ; WAXMAN DJ EVALUATION OF TRIACETYLOLEANDOMYCIN, ALPHA-NAPHTHOFLAVONE AND DIETHYLDITHIOCARBAMATE AS SELECTIVE CHEMICAL PROBES FOR INHIBITION OF HUMAN CYTOCHROMES P450	195	46
428	20	9444 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 319(2):540-550 GILLAM EMJ; GUO ZY; MARTIN MV; JENKINS CM; GUENGERICH FP EXPRESSION OF CYTOCHROME-P450 2D6 IN ESCHERICHIA-COLI, PURIFICATION, AND SPECTRAL AND CATALYTIC CHARACTERIZATION	65	46
429	22	9726 1995 JOURNAL OF BIOLOGICAL CHEMISTRY 270(31):18175-18178 DENISON MS; WHITLOCK JP XENOBIOTIC-INDUCIBLE TRANSCRIPTION OF CYTOCHROME-P450 GENES	142	46
430	44	10235 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(7):3460-3468 Wu S; Moomaw CR; Tomer KB; Falck JR; Zeldin DC Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart	75	46
431	27	11483 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):11-23 Waxman DJ P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR	194	46
432	9	812 1968 BIOCHIMICA ET BIOPHYSICA ACTA 162(4):518-& WADA F; SHIBATA H; GOTO M; SAKAMOTO Y PARTICIPATION OF MICROSOMAL ELECTRON TRANSPORT SYSTEM INVOLVING CYTOCHROME P-450 IN OMEGA-OXIDATION OF FATTY ACIDS	80	45
433	5	2087 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 54(3):968-975 HILDEBRANDT AG; SPECK M; ROOTS I POSSIBLE CONTROL OF HYDROGEN-PEROXIDE PRODUCTION AND DEGRADATION IN MICROSOMES DURING MIXED-FUNCTION OXIDATION REACTION	92	45
434	8	2945 1976 ANALYTICAL BIOCHEMISTRY 75(2):596-603 MATSUBARA T; KOIKE M; TOUCHI A; TOCHINO Y; SUGENO K QUANTITATIVE-DETERMINATION OF CYTOCHROME-P-450 IN RAT-LIVER HOMOGENATE	325	45
435	25	5010 1984 ACCOUNTS OF CHEMICAL RESEARCH 17(1):9-16 GUENGERICH FP; MACDONALD TL CHEMICAL MECHANISMS OF CATALYSIS BY CYTOCHROMES-P-450 - A UNIFIED VIEW	538	45
436	6	5332 1985 BIOCHIMICA ET BIOPHYSICA ACTA 840(3):409-417 GOKSOYR A PURIFICATION OF HEPATIC-MICROSOMAL CYTOCHROMES-P-450 FROM BETA- NAPHTHOFLAVONE-TREATED ATLANTIC COD (GADUS-MORHUA), A MARINE TELEOST FISH	92	45
437	6	6385 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 272(1):219-225 KOMORI M; NISHIO K; FUJITANI T; OHI H; KITADA M; MIMA S; ITAHASHI K; KAMATAKI T ISOLATION OF A NEW HUMAN-FETAL LIVER CYTOCHROME-P450 CDNA CLONE - EVIDENCE FOR EXPRESSION OF A LIMITED NUMBER OF FORMS OF CYTOCHROME-P450 IN HUMAN-FETAL LIVERS	68	45
438	14	6394 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 274(2):355-365 SCHUETZ JD; MOLOWA DT; GUZELIAN PS CHARACTERIZATION OF A CDNA-ENCODING A NEW MEMBER OF THE GLUCOCORTICOID-RESPONSIVE CYTOCHROMES P450 IN HUMAN-LIVER	60	45
439	1	6578 1989 ENDOCRINOLOGY 125(4):1959-1966 MCALLISTER JM; KERIN JFP; TRANT JM; ESTABROOK RW; MASON JI; WATERMAN MR; SIMPSON ER REGULATION OF CHOLESTEROL SIDE-CHAIN CLEAVAGE AND 17-ALPHA- HYDROXYLASE LYASE ACTIVITIES IN PROLIFERATING HUMAN THECA INTERNA CELLS IN LONG-TERM MONOLAYER-CULTURE	45	45
440	20	6828 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 277(1):166-180 HALVORSON M; GREENWAY D; EBERHART D; FITZGERALD K; PARKINSON A RECONSTITUTION OF TESTOSTERONE OXIDATION BY PURIFIED RAT CYTOCHROME-P450P (IIIA1)	82	45
441	21	7057 1990 EUROPEAN JOURNAL OF BIOCHEMISTRY 191(2):437-444 MOREL F; BEAUNE PH; RATANASAVANH D; FLINOIS JP; YANG CS; GUENGERICH FP; GUILLOUZO A EXPRESSION OF CYTOCHROME-P-450 ENZYMES IN CULTURED HUMAN HEPATOCYTES	120	45
442	12	7439 1991 BIOCHEMISTRY 30(25):6097-6102 KRONBACH T; KEMPER B; JOHNSON EF A HYPERVARIABLE REGION OF P450IIC5 CONFERS PROGESTERONE 21- HYDROXYLASE ACTIVITY TO P450IIC1	60	45
443	17	8677 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(6):4453-4457 HALPERT JR; HE YA ENGINEERING OF CYTOCHROME-P450 2B1 SPECIFICITY - CONVERSION OF AN ANDROGEN 16-BETA-HYDROXYLASE TO A 15-ALPHA-HYDROXYLASE	78	45
444	15	8690 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(18):13565-13570 KARARA A; MAKITA K; JACOBSON HR; FALCK JR; GUENGERICH FP; DUBOIS RN; CAPDEVILA JH MOLECULAR-CLONING, EXPRESSION, AND ENZYMATIC CHARACTERIZATION OF THE RAT-KIDNEY CYTOCHROME-P-450 ARACHIDONIC-ACID EPOXYGENASE	61	45
445	15	8732 1993 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 265(1):401-407 TASSANEEYAKUL W; BIRKETT DJ; VERONESE ME; MCMANUS ME; TUKEY RH; QUATTROCHI LC; GELBOIN HV; MINERS JO SPECIFICITY OF SUBSTRATE AND INHIBITOR PROBES FOR HUMAN CYTOCHROMES-P450 1A1 AND 1A2	186	45
446	4	8791 1993 NATURE 366(6452):276-279 HOLTON TA; BRUGLIERA F; LESTER DR; TANAKA Y; HYLAND CD; MENTING JGT; LU CY; FARCY E; STEVENSON TW; CORNISH EC CLONING AND EXPRESSION OF CYTOCHROME-P450 GENES-CONTROLLING FLOWER COLOR	118	45
447	27	8919 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 311(2):402-417 SHET MS; FISHER CW; ARLOTTO MP; SHACKLETON CHL; HOLMANS PL; MARTINWIXTROM CA; SAEKI Y; ESTABROOK RW PURIFICATION AND ENZYMATIC-PROPERTIES OF A RECOMBINANT FUSION PROTEIN EXPRESSED IN ESCHERICHIA-COLI CONTAINING THE DOMAINS OF BOVINE P450 17A AND RAT NADPH-P450 REDUCTASE	45	45
448	26	8922 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 312(1):59-66 GILLAM EMJ; GUO ZY; GUENGERICH FP EXPRESSION OF MODIFIED HUMAN CYTOCHROME-P450 2E1 IN ESCHERICHIA-COLI, PURIFICATION, AND SPECTRAL AND CATALYTIC PROPERTIES	75	45
449	30	9793 1995 JOURNAL OF VASCULAR RESEARCH 32(2):79-92 HARDER DR; CAMPBELL WB; ROMAN RJ ROLE OF CYTOCHROME-P-450 ENZYMES AND METABOLITES OF ARACHIDONIC-ACID IN THE CONTROL OF VASCULAR TONE	166	45
450	31	9941 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 325(2):174-182 Yamazaki H; Nakano M; Imai Y; Ueng YF; Guengerich FP; Shimada T Roles of cytochrome b(5) in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes	79	45
451	6	857 1968 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 349(11):1624-& SCHENKMAN JB EFFECT OF SUBSTRATES ON HEPATIC MICROSOMAL CYTOCHROME P-450	49	44
452	9	923 1968 MOLECULAR PHARMACOLOGY 4(6):613-& SCHENKMAN JB; SATO R RELATIONSHIP BETWEEN PH-INDUCED SPECTRAL CHANGE IN FERRIPROTOHEME AND SUBSTRATE-INDUCED SPECTRAL CHANGE OF HEPATIC MICROSOMAL MIXED-FUNCTION OXIDASE	47	44
453	11	1748 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 151(2):391-& JANSSON I; SCHENKMAN JB; ERNSTER L; ORRENIUS S STUDY OF INTERACTION OF A SERIES OF SUBSTITUTED BARBITURIC ACIDS WITH HEPATIC MICROSOMAL MONOOXYGENASE	68	44
454	20	1757 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 153(2):480-494 HRYCAY EG; OBRIEN PJ CYTOCHROME-P-450 AS A MICROSOMAL PEROXIDASE IN STEROID HYDROPEROXIDE REDUCTION	101	44
455	11	3754 1979 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 90(3):715-720 SUGIYAMA T; MIKI N; YAMANO T OBLIGATORY REQUIREMENT OF CYTOCHROME-B-5 IN THE PARA- NITROANISOLE O-DEMETHYLATION REACTION CATALYZED BY CYTOCHROME- P-450 WITH A HIGH-AFFINITY FOR CYTOCHROME-B-5	65	44
456	4	4988 1983 PROSTAGLANDINS 26(1):13-21 KUTSKY P; FALCK JR; WEISS GB; MANNA S; CHACOS N; CAPDEVILA J EFFECTS OF NEWLY REPORTED ARACHIDONIC-ACID METABOLITES ON MICROSOMAL CA++ BINDING, UPTAKE AND RELEASE	60	44
457	6	6712 1989 MOLECULAR PHARMACOLOGY 35(5):617-625 GASSER R; PHILPOT RM PRIMARY STRUCTURES OF CYTOCHROME-P-450 ISOZYME-5 FROM RABBIT AND RAT AND REGULATION OF SPECIES-DEPENDENT EXPRESSION AND INDUCTION IN LUNG AND LIVER - IDENTIFICATION OF CYTOCHROME-P- 450 GENE SUBFAMILY IVB	62	44
458	6	7059 1990 EUROPEAN JOURNAL OF BIOCHEMISTRY 193(2):559-565 TODA K; TERASHIMA M; KAWAMOTO T; SUMIMOTO H; YOKOYAMA Y; KURIBAYASHI I; MITSUUCHI Y; MAEDA T; YAMAMOTO Y; SAGARA Y; IKEDA H; SHIZUTA Y STRUCTURAL AND FUNCTIONAL-CHARACTERIZATION OF HUMAN AROMATASE P-450 GENE	96	44
459	35	8600 1993 DRUG METABOLISM REVIEWS 25(4):453-484 WRIGHTON SA; VANDENBRANDEN M; STEVENS JC; SHIPLEY LA; RING BJ; RETTIE AE; CASHMAN JR IN-VITRO METHODS FOR ASSESSING HUMAN HEPATIC DRUG-METABOLISM - THEIR USE IN DRUG DEVELOPMENT	140	44
460	14	8961 1994 BIOCHEMICAL PHARMACOLOGY 47(1):25-37 NEBERT DW DRUG-METABOLIZING-ENZYMES IN LIGAND-MODULATED TRANSCRIPTION	155	44
461	33	9325 1994 PHARMACOGENETICS 4(4):171-184 WATKINS PB NONINVASIVE TESTS OF CYP3A ENZYMES	199	44
462	12	9378 1994 TOXICOLOGY LETTERS 70(2):133-138 GUENGERICH FP CATALYTIC SELECTIVITY OF HUMAN CYTOCHROME-P450 ENZYMES - RELEVANCE TO DRUG-METABOLISM AND TOXICITY	94	44
463	26	9902 1995 XENOBIOTICA 25(3):261-270 BALDWIN SJ; BLOOMER JC; SMITH GJ; AYRTON AD; CLARKE SE; CHENERY RJ KETOCONAZOLE AND SULFAPHENAZOLE AS THE RESPECTIVE SELECTIVE INHIBITORS OF P4503A AND 2C9	155	44
464	1	24 1958 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 76(2):509-531 CHANCE B; SACKTOR B RESPIRATORY METABOLISM OF INSECT FLIGHT MUSCLE .2. KINETICS OF RESPIRATORY ENZYMES IN FLIGHT MUSCLE SARCOSOMES	95	43
465	6	308 1964 BIOCHIMICA ET BIOPHYSICA ACTA 93(3):445-& LINDENMAYER A; SMITH L CYTOCHROMES + OTHER PIGMENTS OF BAKERS YEAST GROWN AEROBICALLY + ANAEROBICALLY	110	43
466	1	472 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 24(1):10-& SIMPSON ER; BOYD GS CHOLESTEROL SIDE-CHAIN CLEVAGE SYSTEM OF ADRENAL CORTEX - A MIXED-FUNCTION OXIDASE	94	43
467	3	688 1967 JOURNAL OF BIOLOGICAL CHEMISTRY 242(6):1102-& MURAKAMI K; MASON HS AN ELECTRON SPIN RESONANCE STUDY OF MICROSOMAL FEX	93	43
468	15	1407 1970 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67(1):172-& PEISACH J; BLUMBERG WE ELECTRON PARAMAGNETIC RESONANCE STUDY OF HIGH-SPIN AND LOW-SPIN FORMS OF CYTOCHROME P-450 IN LIVER AND IN LIVER MICROSOMES FROM A METHYCHOLANTHRENE-TREATED RABBIT	101	43
469	11	1958 1972 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 183(1):206-& BEND JR; FOUTS JR; EASTERLI.RE; GRAM TE; HOOK GER COMPARATIVE STUDY OF HEPATIC AND PULMONARY MICROSOMAL MIXED- FUNCTION OXIDASE SYSTEMS IN RABBIT	145	43
470	12	2062 1973 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 155(2):355-360 WATERMAN MR; ULLRICH V; ESTABROOK RW EFFECT OF SUBSTRATE ON SPIN STATE OF CYTOCHROME-P-450 IN HEPATIC MICROSOMES	43	43
471	21	2193 1973 DRUG METABOLISM AND DISPOSITION 1(1):98-110 ESTABROOK RW; MATSUBARA T; MASON JI; WERRINGLOER J; BARON J STUDIES ON MOLECULAR FUNCTION OF CYTOCHROME-P-450 DURING DRUG- METABOLISM	43	43
472	19	2331 1973 MOLECULAR PHARMACOLOGY 9(4):470-485 CORREIA MA; MANNERIN.GJ REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE SYNERGISM OF REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE-DEPENDENT MIXED-FUNCTION OXIDASE SYSTEM OF HEPATIC MICROSOMES .2. ROLE OF TYPE 1 DRUG-BINDING SITE OF CYTOCHROME-P-450	58	43
473	13	2546 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(1):94-101 YU CA; GUNSALUS IC; KATAGIRI M; SUHARA K; TAKEMORI S CYTOCHROME P-450CAM .1. CRYSTALLIZATION AND PROPERTIES	133	43
474	14	2559 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(17):5599-5606 POLAND AP; GLOVER E; ROBINSON JR; NEBERT DW GENETIC EXPRESSION OF ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY - INDUCTION OF MONOOXYGENASE ACTIVITIES AND CYTOCHROME P1-450 FORMATION BY 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN IN MICE GENETICALLY NONRESPONSIVE TO OTHER AROMATIC-HYDROCARBON	257	43
475	10	2872 1975 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 6(3-4):419-425 ESTABROOK RW; MARTINEZZEDILLO G; YOUNG S; PETERSON JA; MCCARTHY J INTERACTION OF STEROIDS WITH LIVER MICROSOMAL CYTOCHROME-P-450 - GENERAL HYPOTHESIS	43	43
476	18	3297 1977 BIOCHIMICA ET BIOPHYSICA ACTA 465(2):362-370 YANG CS; STRICKHART FS; KICHA LP EFFECT OF TEMPERATURE ON MONOXYGENASE REACTIONS IN MICROSOMAL MEMBRANE	76	43
477	14	4354 1981 EUROPEAN JOURNAL OF BIOCHEMISTRY 116(3):521-526 NOSHIRO M; ULLRICH V; OMURA T CYTOCHROME-B5 AS ELECTRON-DONOR FOR OXY-CYTOCHROME P-450	57	43
478	18	4375 1981 JOURNAL OF BIOCHEMISTRY 89(2):351-362 IMAI Y THE ROLES OF CYTOCHROME-B5 IN RECONSTITUTED MONO-OXYGENASE SYSTEMS CONTAINING VARIOUS FORMS OF HEPATIC-MICROSOMAL CYTOCHROME-P-450	73	43
479	4	4657 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(11):6231-6241 AUGUSTO O; KUNZE KL; DEMONTELLANO PRO N-PHENYLPROTOPORPHYRIN-IX FORMATION IN THE HEMOGLOBIN- PHENYLHYDRAZINE REACTION - EVIDENCE FOR A PROTEIN-STABILIZED IRON-PHENYL INTERMEDIATE	156	43
480	8	5030 1984 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 231(2):511-517 CAPDEVILA J; PRAMANIK B; NAPOLI JL; MANNA S; FALCK JR ARACHIDONIC-ACID EPOXIDATION - EPOXYEICOSATRIENOIC ACIDS ARE ENDOGENOUS CONSTITUENTS OF RAT-LIVER	60	43
481	24	6025 1988 ANNUAL REVIEW OF PHYSIOLOGY 50():427-440 SIMPSON ER; WATERMAN MR REGULATION OF THE SYNTHESIS OF STEROIDOGENIC ENZYMES IN ADRENAL-CORTICAL CELLS BY ACTH	317	43
482	8	6030 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 261(2):257-263 CAPDEVILA J; GIL L; ORELLANA M; MARNETT LJ; MASON JI; YADAGIRI P; FALCK JR INHIBITORS OF CYTOCHROME P-450-DEPENDENT ARACHIDONIC-ACID METABOLISM	173	43
483	4	6304 1988 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85(12):4214-4217 ZAPHIROPOULOS PG; MODE A; STROM A; MOLLER C; FERNANDEZ C; GUSTAFSSON JA CDNA CLONING, SEQUENCE, AND REGULATION OF A MAJOR FEMALE- SPECIFIC AND GROWTH HORMONE-INDUCIBLE RAT-LIVER CYTOCHROME-P- 450 ACTIVE IN 15-BETA-HYDROXYLATION OF STEROID SULFATES	70	43
484	4	6395 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 274(2):481-490 ASSEFFA A; SMITH SJ; NAGATA K; GILLETTE J; GELBOIN HV; GONZALEZ FJ NOVEL EXOGENOUS HEME-DEPENDENT EXPRESSION OF MAMMALIAN CYTOCHROME-P450 USING BACULOVIRUS	76	43
485	9	6750 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(5):1465-1469 FEYEREISEN R; KOENER JF; FARNSWORTH DE; NEBERT DW ISOLATION AND SEQUENCE OF CDNA-ENCODING A CYTOCHROME-P-450 FROM AN INSECTICIDE-RESISTANT STRAIN OF THE HOUSE-FLY, MUSCA- DOMESTICA	86	43
486	8	6909 1990 BIOCHEMISTRY 29(4):873-879 JOHNSON EF; WALKER DL; GRIFFIN KJ; CLARK JE; OKITA RT; MUERHOFF AS; MASTERS BS CLONING AND EXPRESSION OF 3 RABBIT KIDNEY CDNAS ENCODING LAURIC ACID OMEGA-HYDROXYLASES	59	43
487	8	6968 1990 CANCER RESEARCH 50(14):4315-4321 OMIECINSKI CJ; REDLICH CA; COSTA P INDUCTION AND DEVELOPMENTAL EXPRESSION OF CYTOCHROME-P450IA1 MESSENGER-RNA IN RAT AND HUMAN TISSUES - DETECTION BY THE POLYMERASE CHAIN-REACTION	148	43
488	10	7145 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(28):17197-17201 MATSUNAGA E; ZEUGIN T; ZANGER UM; AOYAMA T; MEYER UA; GONZALEZ FJ SEQUENCE REQUIREMENTS FOR CYTOCHROME-P-450IID1 CATALYTIC ACTIVITY - A SINGLE AMINO-ACID CHANGE (ILE380 PHE) SPECIFICALLY DECREASES VMAX OF THE ENZYME FOR BUFURALOL BUT NOT DEBRISOQUINE HYDROXYLATION	66	43
489	19	8271 1992 MOLECULAR PHARMACOLOGY 41(5):856-864 SHIMADA T; YUN CH; YAMAZAKI H; GAUTIER JC; BEAUNE PH; GUENGERICH FP CHARACTERIZATION OF HUMAN LUNG MICROSOMAL CYTOCHROME-P-450 1A1 AND ITS ROLE IN THE OXIDATION OF CHEMICAL CARCINOGENS	163	43
490	36	10253 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(44):27438-27444 Yamazaki H; Johnson WW; Ueng YF; Shimada T; Guengerich FP Lack of electron transfer from cytochrome b(5) in stimulation of catalytic activities of cytochrome P450 3A4 - Characterization of a reconstituted cytochrome P450 3A4 NADPH- cytochrome P450 reductase system and studies with apo- cytochrome b(5)	63	43
491	2	467 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 22(5):585-& SCHATZ G; RACKER E; TYLER DD; GONZE J; ESTABROOK RW STUDIES OF DPNH-CYTOCHROME B SEGMENT OF RESPIRATORY CHAIN OF BAKERS YEAST	42	42
492	1	791 1968 BIOCHEMICAL PHARMACOLOGY 17(9):1865-& DAVIES DS; GIGON PL; GILLETTE JR SEX DIFFERENCES IN KINETIC CONSTANTS FOR N-DEMETHYLATION OF ETHYLMORPHINE BY RAT LIVER MICROSOMES	102	42
493	10	961 1969 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 129(1):362-& BOIS R; ESTABROOK RW NONHEME IRON PROTEIN AS A POSSIBLE SITE OF ROTENONE INHIBITION OF MITOCHONDRIAL NADH DEHYDROGENASE	42	42
494	22	1356 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(20):5441-& WHYSNER JA; RAMSEYER J; HARDING BW SUBSTRATE-INDUCED CHANGES IN VISIBLE ABSORPTION AND ELECTRON SPIN RESONANCE PROPERTIES OF ADRENAL CORTEX MITOCHONDRIAL-P450	62	42
495	14	2685 1975 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 63(3):588-593 TAKEMORI S; SUHARA K; HASHIMOTO S; HASHIMOTO M; SATO H; GOMI T; KATAGIRI M PURIFICATION OF CYTOCHROME-P-450 FROM BOVINE ADRENOCORTICAL MITOCHONDRIA BY AN ANILINE-SEPHAROSE AND PROPERTIES	90	42
496	19	3080 1976 EUROPEAN JOURNAL OF BIOCHEMISTRY 61(1):43-52 HRYCAY EG; GUSTAFSSON JA; INGELMANSUNDBERG M; ERNSTER L INVOLVEMENT OF CYTOCHROME-P-450 IN HEPATIC MICROSOMAL STEROID HYDROXYLATION REACTIONS SUPPORTED BY SODIUM PERIODATE, SODIUM- CHLORITE, AND ORGANIC HYDROPEROXIDES	105	42
497	4	3123 1976 JOURNAL OF BIOLOGICAL CHEMISTRY 251(4):1116-1124 LIPSCOMB JD; SLIGAR SG; NAMTVEDT MJ; GUNSALUS IC AUTOOXIDATION AND HYDROXYLATION REACTIONS OF OXYGENATED CYTOCHROME P-450CAM	113	42
498	39	3448 1977 PHARMACOLOGY & THERAPEUTICS PART A-CHEMOTHERAPY TOXICOLOGY AND METABOLIC INHIBITORS 2(1):227-245 FRANKLIN MR INHIBITION OF MIXED-FUNCTION OXIDATIONS BY SUBSTRATES FORMING REDUCED CYTOCHROME-P-450 METABOLIC-INTERMEDIATE COMPLEXES	142	42
499	26	3920 1979 MOLECULAR AND CELLULAR ENDOCRINOLOGY 13(3):213-227 SIMPSON ER CHOLESTEROL SIDE-CHAIN CLEAVAGE, CYTOCHROME-P450, AND THE CONTROL OF STEROIDOGENESIS	225	42
500	39	3939 1979 PHARMACOLOGY & THERAPEUTICS 6(1):99-121 GUENGERICH FP ISOLATION AND PURIFICATION OF CYTOCHROME-P-450, AND THE EXISTENCE OF MULTIPLE FORMS	215	42

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