#	Cited nodes	Nodes / Authors	GCS	LCS
2101	10	5952 1987 MOLECULAR PHARMACOLOGY 32(2):189-194 MCMANUS ME; HALL PD; STUPANS I; BRENNAN J; BURGESS W; ROBSON R; BIRKETT DJ IMMUNOHISTOCHEMICAL LOCALIZATION AND QUANTITATION OF NADPH- CYTOCHROME P-450 REDUCTASE IN HUMAN-LIVER	26	13
2102	4	5954 1987 MOLECULAR PHARMACOLOGY 32(5):706-709 OKITA RT; SOBERMAN RJ; BERGHOLTE JM; MASTERS BSS; HAYES R; MURPHY RC OMEGA-HYDROXYLATION OF 15-HYDROXYEICOSATETRAENOIC ACID BY LUNG MICROSOMES FROM PREGNANT RABBITS	19	13
2103	2	5971 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(11):3609-3613 YUBISUI T; NAITOH Y; ZENNO SH; TAMURA M; TAKESHITA M; SAKAKI Y MOLECULAR-CLONING OF CDNAS OF HUMAN-LIVER AND PLACENTA NADH- CYTOCHROME-B5 REDUCTASE	49	13
2104	14	5996 1987 XENOBIOTICA 17(1):45-57 LAVRIJSEN K; VANHOUDT J; THIJS D; MEULDERMANS W; HEYKANTS J INTERACTION OF MICONAZOLE, KETOCONAZOLE AND ITRACONAZOLE WITH RAT-LIVER MICROSOMES	40	13
2105	10	6101 1988 BIOCHEMICAL PHARMACOLOGY 37(24):4643-4651 BALLARD SA; LODOLA A; TARBIT MH A COMPARATIVE-STUDY OF 1-SUBSTITUTED IMIDAZOLE AND 1,2,4- TRIAZOLE ANTIFUNGAL COMPOUNDS AS INHIBITORS OF TESTOSTERONE HYDROXYLATIONS CATALYZED BY MOUSE HEPATIC-MICROSOMAL CYTOCHROMES-P-450	37	13
2106	6	6160 1988 CHEMICO-BIOLOGICAL INTERACTIONS 67(1-2):129-138 BLAICH G; GOTTLICHER M; CIKRYT P; METZLER M INDUCTION OF P-450 ISOENZYME ACTIVITIES IN SYRIAN GOLDEN- HAMSTER LIVER COMPARED TO RAT-LIVER AS PROBED BY THE RATE OF 7- ALKOXYRESORUFIN-O-DEALKYLATION	26	13
2107	12	6184 1988 DRUG METABOLISM AND DISPOSITION 16(2):259-264 PAPAC DI; FRANKLIN MR N-BENZYLIMIDAZOLE, A HIGH MAGNITUDE INDUCER OF RAT HEPATIC CYTOCHROME-P-450 EXHIBITING BOTH POLYCYCLIC AROMATIC HYDROCARBON-TYPE AND PHENOBARBITAL-TYPE INDUCTION OF PHASE-I AND PHASE-II DRUG-METABOLIZING-ENZYMES	30	13
2108	4	6206 1988 GENE 68(2):229-237 KIRSCH DR; LAI MH; OSULLIVAN J ISOLATION OF THE GENE FOR CYTOCHROME-P450L1A1 (LANOSTEROL 14- ALPHA-DEMETHYLASE) FROM CANDIDA-ALBICANS	47	13
2109	2	6250 1988 JOURNAL OF EXPERIMENTAL MEDICINE 168(2):801-806 GUEGUEN M; MEUNIERROTIVAL M; BERNARD O; ALVAREZ F ANTI-LIVER KIDNEY MICROSOME ANTIBODY RECOGNIZES A CYTOCHROME- P450 FROM THE IID SUBFAMILY	55	13
2110	4	6274 1988 MOLECULAR AND CELLULAR ENDOCRINOLOGY 59(3):249-253 YANASE T; KAGIMOTO M; MATSUI N; SIMPSON ER; WATERMAN MR COMBINED 17-ALPHA-HYDROXYLASE/17,20-LYASE DEFICIENCY DUE TO A STOP CODON IN THE N-TERMINAL REGION OF 17-ALPHA-HYDROXYLASE CYTOCHROME-P-450	39	13
2111	48	6294 1988 PHARMACOLOGICAL REVIEWS 40(4):229-241 FITZPATRICK FA; MURPHY RC CYTOCHROME-P-450 METABOLISM OF ARACHIDONIC-ACID - FORMATION AND BIOLOGICAL ACTIONS OF EPOXYGENASE-DERIVED EICOSANOIDS	35	13
2112	6	6449 1989 BIOCHEMICAL PHARMACOLOGY 38(24):4439-4444 ODA Y; IMAOKA S; NAKAHIRA Y; ASADA A; FUJIMORI M; FUJITA S; FUNAE Y METABOLISM OF LIDOCAINE BY PURIFIED RAT-LIVER MICROSOMAL CYTOCHROME-P-450 ISOZYMES	43	13
2113	8	6456 1989 BIOCHEMISTRY 28(8):3145-3152 KOCH JA; WAXMAN DJ POSTTRANSLATIONAL MODIFICATION OF HEPATIC CYTOCHROME-P-450 - PHOSPHORYLATION OF PHENOBARBITAL-INDUCIBLE P-450 FORMS PB-4 (IIB1) AND PB-5 (IIB2) IN ISOLATED RAT HEPATOCYTES AND INVIVO	30	13
2114	10	6496 1989 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 28(2):166-170 BACK DJ; STEVENSON P; TJIA JF COMPARATIVE EFFECTS OF 2 ANTIMYCOTIC AGENTS, KETOCONAZOLE AND TERBINAFINE ON THE METABOLISM OF TOLBUTAMIDE, ETHINYLESTRADIOL, CYCLOSPORINE AND ETHOXYCOUMARIN BY HUMAN-LIVER MICROSOMES INVITRO	62	13
2115	12	6566 1989 DRUG METABOLISM REVIEWS 20(2-4):541-551 KOOP DR; LAETHEM CL; TIERNEY DJ THE UTILITY OF PARA-NITROPHENOL HYDROXYLATION IN P450IIE1 ANALYSIS	84	13
2116	13	6579 1989 ENDOCRINOLOGY 125(6):2935-2944 SHAPIRO BH; MACLEOD JN; PAMPORI NA; MORRISSEY JJ; LAPENSON DP; WAXMAN DJ SIGNALING ELEMENTS IN THE ULTRADIAN RHYTHM OF CIRCULATING GROWTH-HORMONE REGULATING EXPRESSION OF SEX-DEPENDENT FORMS OF HEPATIC CYTOCHROME P450	54	13
2117	24	6587 1989 EUROPEAN JOURNAL OF BIOCHEMISTRY 184(2):267-285 MANSUY D; BATTIONI P; BATTIONI JP CHEMICAL-MODEL SYSTEMS FOR DRUG-METABOLIZING CYTOCHROME-P-450- DEPENDENT MONOOXYGENASES	139	13
2118	5	6625 1989 JOURNAL OF BIOCHEMISTRY 105(5):676-679 HASHIMOTO T; MOROHASHI KI; OMURA T CLONING AND CHARACTERIZATION OF BOVINE CYTOCHROME P-450(11- BETA) GENES	34	13
2119	2	6647 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(30):17754-17758 SHEN ES; WHITLOCK JP THE POTENTIAL ROLE OF DNA METHYLATION IN THE RESPONSE TO 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN	48	13
2120	1	6732 1989 NUCLEIC ACIDS RESEARCH 17(12):4888-4888 YAMANO S; NAGATA K; YAMAZOE Y; KATO R; GELBOIN HV; GONZALEZ FJ CDNA AND DEDUCED AMINO-ACID SEQUENCES OF HUMAN P450 IIA3 (CYP2A3)	24	13
2121	5	6834 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 280(1):229-232 MANNS MP; GRIFFIN KJ; QUATTROCHI LC; SACHER M; THALER H; TUKEY RH; JOHNSON EF IDENTIFICATION OF CYTOCHROME-P450IA2 AS A HUMAN AUTOANTIGEN	44	13
2122	4	6853 1990 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 166(2):860-866 DOECKE CJ; SANSOM LN; MCMANUS ME PHENYTOIN 4-HYDROXYLATION BY RABBIT LIVER P450IIC3 AND IDENTIFICATION OF ORTHOLOGS IN HUMAN LIVER-MICROSOMES	31	13
2123	10	6865 1990 BIOCHEMICAL JOURNAL 267(1):221-226 BALL SE; FORRESTER LM; WOLF CR; BACK DJ DIFFERENCES IN THE CYTOCHROME-P-450 ISOENZYMES INVOLVED IN THE 2-HYDROXYLATION OF ESTRADIOL AND 17-ALPHA-ETHINYLESTRADIOL - RELATIVE ACTIVITIES OF RAT AND HUMAN LIVER-ENZYMES	55	13
2124	9	6959 1990 CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 68(9):1278-1285 WOODCROFT KJ; BEND JR N-ARALKYLATED DERIVATIVES OF 1-AMINOBENZOTRIAZOLE AS ISOZYME- SELECTIVE, MECHANISM-BASED INHIBITORS OF GUINEA-PIG HEPATIC CYTOCHROME-P-450 DEPENDENT MONOOXYGENASE ACTIVITY	18	13
2125	16	6974 1990 CANCER SURVEYS 9(3):437-474 WOLF CR METABOLIC FACTORS IN CANCER SUSCEPTIBILITY	39	13
2126	10	7034 1990 DRUG METABOLISM AND DISPOSITION 18(6):1031-1037 WOODCROFT KJ; SZCZEPAN EW; KNICKLE LC; BEND JR 3 N-ARALKYLATED DERIVATIVES OF 1-AMINOBENZOTRIAZOLE AS POTENT AND ISOZYME-SELECTIVE, MECHANISM-BASED INHIBITORS OF GUINEA-PIG PULMONARY CYTOCHROME-P-450 INVITRO	23	13
2127	9	7165 1990 JOURNAL OF CLINICAL INVESTIGATION 86(5):1434-1441 BYSANI GK; KENNEDY TP; KY N; RAO NV; BLAZE CA; HOIDAL JR ROLE OF CYTOCHROME-P-450 IN REPERFUSION INJURY OF THE RABBIT LUNG	43	13
2128	12	7191 1990 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 35(3-4):429-440 GEMZIK B; HALVORSON MR; PARKINSON A PRONOUNCED AND DIFFERENTIAL-EFFECTS OF IONIC-STRENGTH AND PH ON TESTOSTERONE OXIDATION BY MEMBRANE-BOUND AND PURIFIED FORMS OF RAT-LIVER MICROSOMAL CYTOCHROME-P-450	23	13
2129	8	7208 1990 LIPIDS 25(8):481-490 VANROLLINS M SYNTHESIS AND CHARACTERIZATION OF CYTOCHROME-P-450 EPOXYGENASE METABOLITES OF EICOSAPENTAENOIC ACID	30	13
2130	4	7213 1990 METHODS IN ENZYMOLOGY 187():253-267 MUERHOFF AS; WILLIAMS DE; MASTERS BSS PURIFICATION AND PROPERTIES OF PREGNANCY-INDUCIBLE RABBIT LUNG CYTOCHROME-P-450 PROSTAGLANDIN OMEGA-HYDROXYLASE	16	13
2131	11	7227 1990 MOLECULAR ENDOCRINOLOGY 4(2):295-303 JANECZKO R; WAXMAN DJ; LEBLANC GA; MORVILLE A; ADESNIK M HORMONAL-REGULATION OF LEVELS OF THE MESSENGER-RNA ENCODING HEPATIC P450 2C (IIC11), A CONSTITUTIVE MALE-SPECIFIC FORM OF CYTOCHROME-P450	29	13
2132	13	7240 1990 MOLECULAR PHARMACOLOGY 38(2):192-197 WESTIN S; STROM A; GUSTAFSSON JA; ZAPHIROPOULOS PG GROWTH-HORMONE REGULATION OF THE CYTOCHROME-P-450IIC SUBFAMILY IN THE RAT - INDUCTIVE, REPRESSIVE, AND TRANSCRIPTIONAL EFFECTS ON P-450F (IIC7) AND P-450PB1 (IIC6) GENE-EXPRESSION	40	13
2133	9	7282 1990 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87(24):9756-9760 TRANT JM; LORENCE MC; JOHNSON EF; SHACKLETON CHL; MASON JI; ESTABROOK RW CHARACTERIZATION OF THE STEROID-METABOLIZING CAPACITY OF THE HEPATIC CYTOCHROME-P450IIC5 EXPRESSED IN COS-1 CELLS - 3-BETA- HYDROXYSTEROID DEHYDROGENASE DELTA-5-]4 ISOMERASE TYPE ACTIVITY	13	13
2134	1	7404 1991 BIOCHEMICAL PHARMACOLOGY 41(4):553-560 DANSETTE PM; AMAR C; VALADON P; PONS C; BEAUNE PH; MANSUY D HYDROXYLATION AND FORMATION OF ELECTROPHILIC METABOLITES OF TIENILIC ACID AND ITS ISOMER BY HUMAN LIVER-MICROSOMES - CATALYSIS BY A CYTOCHROME-P450 IIC DIFFERENT FROM THAT RESPONSIBLE FOR MEPHENYTOIN HYDROXYLATION	41	13
2135	16	7429 1991 BIOCHEMICAL PHARMACOLOGY 42(12):2377-2385 LEE QP; FANTEL AG; JUCHAU MR HUMAN EMBRYONIC CYTOCHROME P450S - PHENOXAZONE ETHERS AS PROBES FOR EXPRESSION OF FUNCTIONAL ISOFORMS DURING ORGANOGENESIS	32	13
2136	7	7450 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1076(1):130-136 JUNG C; RISTAU O; REIN H THE HIGH-SPIN LOW-SPIN EQUILIBRIUM IN CYTOCHROME-P-450 - A NEW METHOD FOR DETERMINATION OF THE HIGH-SPIN CONTENT	27	13
2137	14	7709 1991 METHODS IN ENZYMOLOGY 206():423-431 RODRIGUES AD; PROUGH RA INDUCTION OF CYTOCHROMES-P450IA1 AND CYTOCHROME-P450IA2 AND MEASUREMENT OF CATALYTIC ACTIVITIES	45	13
2138	2	7715 1991 METHODS IN ENZYMOLOGY 206():577-586 RAUCY JL; LASKER JM ISOLATION OF P450-ENZYMES FROM HUMAN LIVER	33	13
2139	7	7735 1991 MOLECULAR PHARMACOLOGY 40(5):859-867 EBERHART DC; GEMZIK B; HALVORSON MR; PARKINSON A SPECIES-DIFFERENCES IN THE TOXICITY AND CYTOCHROME-P450-IIIA- DEPENDENT METABOLISM OF DIGITOXIN	36	13
2140	19	7856 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 293(2):342-348 SPINK DC; EUGSTER HP; LINCOLN DW; SCHUETZ JD; SCHUETZ EG; JOHNSON JA; KAMINSKY LS; GIERTHY JF 17 BETA-ESTRADIOL HYDROXYLATION CATALYZED BY HUMAN CYTOCHROME P450 1A1 - A COMPARISON OF THE ACTIVITIES INDUCED BY 2,3,7,8- TETRACHLORODIBENZO-P-DIOXIN IN MCF-7 CELLS WITH THOSE FROM HETEROLOGOUS EXPRESSION OF THE CDNA	112	13
2141	5	7913 1992 BIOCHEMICAL PHARMACOLOGY 43(8):1876-1879 JONES SM; BOOBIS AR; MOORE GE; STANIER PM EXPRESSION OF CYP2E1 DURING HUMAN FETAL DEVELOPMENT - METHYLATION OF THE CYP2E1 GENE IN HUMAN FETAL AND ADULT LIVER SAMPLES	28	13
2142	3	7992 1992 CANCER RESEARCH 52(10):2977-2979 RAO MS; SUBBARAO V; YELDANDI AV; REDDY JK HEPATOCARCINOGENICITY OF DEHYDROEPIANDROSTERONE IN THE RAT	73	13
2143	13	8017 1992 CHEMICAL REVIEWS 92(6):1411-1456 MEUNIER B METALLOPORPHYRINS AS VERSATILE CATALYSTS FOR OXIDATION REACTIONS AND OXIDATIVE DNA CLEAVAGE	808	13
2144	16	8024 1992 CLINICAL PHARMACOLOGY & THERAPEUTICS 51(3):229-238 LOWN K; KOLARS J; TURGEON K; MERION R; WRIGHTON SA; WATKINS PB THE ERYTHROMYCIN BREATH TEST SELECTIVELY MEASURES P450IIIA IN PATIENTS WITH SEVERE LIVER-DISEASE	80	13
2145	5	8027 1992 CLINICAL PHARMACOLOGY & THERAPEUTICS 52(2):160-169 SOHN DR; KUSAKA M; ISHIZAKI T; SHIN SG; JANG IJ; SHIN JG; CHIBA K INCIDENCE OF S-MEPHENYTOIN HYDROXYLATION DEFICIENCY IN A KOREAN POPULATION AND THE INTERPHENOTYPIC DIFFERENCES IN DIAZEPAM PHARMACOKINETICS	82	13
2146	10	8029 1992 CLINICAL PHARMACOLOGY & THERAPEUTICS 52(5):471-478 TURGEON DK; NORMOLLE DP; LEICHTMAN AB; ANNESLEY TM; SMITH DE; WATKINS PB ERYTHROMYCIN BREATH TEST PREDICTS ORAL CLEARANCE OF CYCLOSPORINE IN KIDNEY-TRANSPLANT RECIPIENTS	58	13
2147	18	8048 1992 DRUG METABOLISM AND DISPOSITION 20(1):56-63 BALL SE; MAURER G; ZOLLINGER M; LADONA M; VICKERS AEM CHARACTERIZATION OF THE CYTOCHROME-P-450 GENE FAMILY RESPONSIBLE FOR THE N-DEALKYLATION OF THE ERGOT ALKALOID CQA- 206-291 IN HUMANS	30	13
2148	17	8072 1992 ENVIRONMENTAL HEALTH PERSPECTIVES 98():81-85 GONZALEZ FJ; GELBOIN HV HUMAN CYTOCHROMES-P450 - EVOLUTION AND CDNA-DIRECTED EXPRESSION	22	13
2149	13	8149 1992 JOURNAL OF BIOCHEMISTRY 112(1):155-162 UNO T; IMAI Y FURTHER-STUDIES ON CHIMERIC-P450 2C2/2C14 HAVING TESTOSTERONE 16-BETA-HYDROXYLASE ACTIVITY WHICH IS ABSENT IN THE PARENTAL- P450S	18	13
2150	17	8455 1993 BIOCHEMICAL PHARMACOLOGY 45(4):899-907 MAENPAA J; RANE A; RAUNIO H; HONKAKOSKI P; PELKONEN O CYTOCHROME-P450 ISOFORMS IN HUMAN FETAL TISSUES RELATED TO PHENOBARBITAL-INDUCIBLE FORMS IN THE MOUSE	21	13
2151	13	8620 1993 EUROPEAN JOURNAL OF PHARMACOLOGY 235(1):1-7 ESCALANTE B; OMATA K; SESSA W; LEE SG; FALCK JR; SCHWARTZMAN ML 20-HYDROXYEICOSATETRAENOIC ACID IS AN ENDOTHELIUM-DEPENDENT VASOCONSTRICTOR IN RABBIT ARTERIES	32	13
2152	17	8623 1993 EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION 248(3):251-261 SCHMALIX WA; MASER H; KIEFER F; REEN R; WIEBEL FJ; GONZALEZ F; SEIDEL A; GLATT H; GREIM H; DOEHMER J STABLE EXPRESSION OF HUMAN CYTOCHROME-P450 1A1 CDNA IN V79 CHINESE-HAMSTER CELLS AND METABOLIC-ACTIVATION OF BENZO[A]PYRENE	49	13
2153	6	8631 1993 FEBS LETTERS 330(2):169-173 UMEMOTO N; KOBAYASHI O; ISHIZAKINISHIZAWA O; TOGURI T CDNAS SEQUENCES ENCODING CYTOCHROME-P450 (CYP71 FAMILY) FROM EGGPLANT SEEDLINGS	17	13
2154	5	8676 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(4):2997-3004 SHAW GC; FULCO AJ INHIBITION BY BARBITURATES OF THE BINDING OF BM3R1 REPRESSOR TO ITS OPERATOR SITE ON THE BARBITURATE-INDUCIBLE CYTOCHROME- P450(BM-3) GENE OF BACILLUS-MEGATERIUM	51	13
2155	11	8889 1994 AMERICAN JOURNAL OF PHYSIOLOGY 266(5):H2098-H2107 HARDER DR; GEBREMEDHIN D; NARAYANAN J; JEFCOAT C; FALCK JR; CAMPBELL WB; ROMAN R FORMATION AND ACTION OF A P-450 4A METABOLITE OF ARACHIDONIC- ACID IN CAT CEREBRAL MICROVESSELS	87	13
2156	16	8947 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 202(3):1731-1737 VILLARD PH; SEREE E; LACARELLE B; THERENEFENOGLIO MC; BARRA Y; ATTOLINI L; BRUGUEROLE B; DURAND A; CATALIN J EFFECT OF CIGARETTE-SMOKE ON HEPATIC AND PULMONARY CYTOCHROMES P450 IN MOUSE - EVIDENCE FOR CYP2E1 INDUCTION IN LUNG	36	13
2157	19	8968 1994 BIOCHEMICAL PHARMACOLOGY 47(10):1883-1895 BERTHOU F; DREANO Y; BELLOC C; KANGAS L; GAUTIER JC; BEAUNE P INVOLVEMENT OF CYTOCHROME-P450 3A ENZYME FAMILY IN THE MAJOR METABOLIC PATHWAYS OF TOREMIFENE IN HUMAN LIVER-MICROSOMES	44	13
2158	8	8990 1994 BIOCHEMISTRY 33(21):6442-6449 VAZ ADN; COON MJ ON THE MECHANISM OF ACTION OF CYTOCHROME-P450 - EVALUATION OF HYDROGEN ABSTRACTION IN OXYGEN-DEPENDENT ALCOHOL OXIDATION	45	13
2159	14	8993 1994 BIOCHEMISTRY 33(26):8029-8034 STRAUB P; LLOYD M; JOHNSON EF; KEMPER B DIFFERENTIAL-EFFECTS OF MUTATIONS IN SUBSTRATE RECOGNITION SITE-1 OF CYTOCHROME-P450-2C2 ON LAURIC ACID AND PROGESTERONE HYDROXYLATION	21	13
2160	9	9135 1994 FEBS LETTERS 343(1):70-74 MUNRO AW; LINDSAY JG; COGGINS JR; KELLY SM; PRICE NC STRUCTURAL AND ENZYMOLOGICAL ANALYSIS OF THE INTERACTION OF ISOLATED DOMAINS OF CYTOCHROME-P-450 BM3	20	13
2161	6	9197 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(27):18083-18089 PALMER CNA; HSU MH; MUERHOFF AS; GRIFFIN KJ; JOHNSON EF INTERACTION OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR- ALPHA WITH THE RETINOID-X RECEPTOR-ALPHA UNMASKS A CRYPTIC PEROXISOME PROLIFERATOR RESPONSE ELEMENT THAT OVERLAPS AN ARP- 1-BINDING SITE IN THE CYP4A6 PROMOTER	70	13
2162	18	9532 1995 BIOCHIMIE 77(7-8):562-572 SEVRIOUKOVA IF; PETERSON JA NADPH-P-450 REDUCTASE - STRUCTURAL AND FUNCTIONAL COMPARISONS OF THE EUKARYOTIC AND PROKARYOTIC ISOFORMS	23	13
2163	11	9557 1995 CANCER RESEARCH 55(3):581-589 CHEN L; WAXMAN DJ INTRATUMORAL ACTIVATION AND ENHANCED CHEMOTHERAPEUTIC EFFECT OF OXAZAPHOSPHORINES FOLLOWING CYTOCHROME-P-450 GENE-TRANSFER - DEVELOPMENT OF A COMBINED CHEMOTHERAPY CANCER GENE-THERAPY STRATEGY	89	13
2164	18	9586 1995 CLINICAL PHARMACOLOGY & THERAPEUTICS 57(1):16-24 LOWN KS; THUMMEL KE; BENEDICT PE; SHEN DD; TURGEON DK; BERENT S; WATKINS PB THE ERYTHROMYCIN BREATH TEST PREDICTS THE CLEARANCE OF MIDAZOLAM	77	13
2165	6	9720 1995 JOURNAL OF BIOLOGICAL CHEMISTRY 270(15):8487-8494 PAN ZQ; DURST F; WERCKREICHHART D; GARDNER HW; CAMARA B; CORNISH K; BACKHAUS RA THE MAJOR PROTEIN OF GUAYULE RUBBER PARTICLES IS A CYTOCHROME- P450 - CHARACTERIZATION BASED ON CDNA CLONING AND SPECTROSCOPIC ANALYSIS OF THE SOLUBILIZED ENZYME AND ITS REACTION-PRODUCTS	66	13
2166	3	9789 1995 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 117(49):12085-12091 NEWCOMB M; LETADICBIADATTI FH; CHESTNEY DL; ROBERTS ES; HOLLENBERG PF A NONSYNCHRONOUS CONCERTED MECHANISM FOR CYTOCHROME-P-450 CATALYZED HYDROXYLATION	142	13
2167	14	9806 1995 MOLECULAR & GENERAL GENETICS 246(1):100-109 FREY M; KLIEM R; SAEDLER H; GIERL A EXPRESSION OF A CYTOCHROME-P450 GENE FAMILY IN MAIZE	37	13
2168	10	9818 1995 MOLECULAR PHARMACOLOGY 47(6):1148-1155 WYSS A; GUSTAFSSON JA; WARNER M CYTOCHROMES P450 OF THE 2D SUBFAMILY IN RAT-BRAIN	26	13
2169	10	9861 1995 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92(18):8428-8432 ROMAN LJ; SHETA EA; MARTASEK P; GROSS SS; LIU Q; MASTERS BSS HIGH-LEVEL EXPRESSION OF FUNCTIONAL-RAT NEURONAL NITRIC-OXIDE SYNTHASE IN ESCHERICHIA-COLI	124	13
2170	12	10078 1996 BRAIN RESEARCH REVIEWS 22(1):1-26 Lephart ED A review of brain aromatase cytochrome P450	133	13
2171	11	10130 1996 CYTOCHROME P450, PT B 272():15-25 Fisher CW; Shet MS; Estabrook RW Construction of plasmids and expression in Escherichia coli of enzymatically active fusion proteins containing the heme-domain of a P450 linked to NADPH-P450 reductase	13	13
2172	106	10333 1996 LIPIDS 31(10):1003-1021 Oliw EH; Bylund J; Herman C Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450	21	13
2173	12	10352 1996 MOLECULAR PHARMACOLOGY 50(1):67-74 Peters JM; Zhou YC; Ram PA; Lee SST; Gonzalez FJ; Waxman DJ Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate	58	13
2174	14	10490 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 339(1):107-114 vonWachenfeldt C; Richardson TH; Cosme J; Johnson EF Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modifications of its N-terminus	22	13
2175	26	10509 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 345(2):342-354 Pritchard MP; Ossetian R; Li DN; Henderson CJ; Burchell B; Wolf CR; Friedberg T A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: Expression of CYP3A4, CYP2A6, and CYP2E1	31	13
2176	8	10750 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(30):18702-18708 Ray WJ; Bain G; Yao M; Gottlieb DI CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family	88	13
2177	10	10866 1997 PHARMACOLOGY & THERAPEUTICS 73(1):67-74 Kaminsky LS; Zhang ZY Human P450 metabolism of warfarin	87	13
2178	14	10873 1997 PLANT JOURNAL 11(2):191-201 Bak S; Kahn RA; Olsen CE; Halkier BA Cloning and expression in Escherichia coli of the obtusifoliol 14 alpha-demethylase of Sorghum bicolor (L) Moench, a cytochrome P450 orthologous to the sterol 14 alpha-demethylases (CYP51) from fungi and mammals	36	13
2179	48	10930 1997 XENOBIOTICA 27(5):443-478 Lewis DFV; Lake BG Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners	33	13
2180	41	10983 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):45-57 Luo G; Zeldin DC; Blaisdell JA; Hodgson E; Goldstein JA Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid	22	13
2181	76	11432 1998 XENOBIOTICA 28(7):617-661 Lewis DFV The CYP2 family: models, mutants and interactions	39	13
2182	20	11455 1999 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 277(3):R607-R623 McGiff JC; Quilley J 20-HETE and the kidney: resolution of old problems and new beginnings	1	13
2183	16	11512 1999 BIOCHEMICAL JOURNAL 339():371-379 Noble MA; Miles CS; Chapman SK; Lysek DA; Mackay AC; Reid GA; Hanzlik RP; Munro AW Roles of key active-site residues in flavocytochrome P450 BM3	17	13
2184	19	11515 1999 BIOCHEMICAL PHARMACOLOGY 57(5):465-480 Rodrigues AD Integrated cytochrome P450 reaction phenotyping - Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes	59	13
2185	11	11714 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(8):4764-4769 Chen JK; Wang DW; Falck JR; Capdevila J; Harris RC Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor	37	13
2186	47	11719 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(25):17777-17788 Ma JX; Qu W; Scarborough PE; Tomer KB; Moomaw CR; Maronpot R; Davis LS; Breyer MD; Zeldin DC Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome p450 highly expressed in Kidney	20	13
2187	7	85 1960 BIOCHEMICAL JOURNAL 76():229-237 GRANT PT; SARGENT JR PROPERTIES OF L-ALPHA-GLYCEROPHOSPHATE OXIDASE AND ITS ROLE IN THE RESPIRATION OF TRYPANOSOMA-RHODESIENSE	136	12
2188	1	159 1962 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 9(1-2):1-& MAITRA PK; ESTABROOK RW ADP AND PHOSPHATE CONTROL OF ETHANOL OXIDATION IN BAKERS YEAST	12	12
2189	3	164 1962 BIOCHEMISTRY 1(6):1017-& MORRIS RO; KING TE THERMAL DENATURATION OF HEART MUSCLE PREPARATION WITH RESPECT TO ITS CAPACITY FOR DPNH OXIDATION	28	12
2190	2	414 1965 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 343(1-3):27-& KRATZ F; STAUDING.H KINETISCHE UNTERSUCHUNGEN ZUR HYDROXYLIERUNG VON CUMARIN MIT LEBERMIKROSOMEN VON KANINCHEN	16	12
2191	14	446 1966 ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 28():155-& KING TE RECONSTITUTION OF RESPIRATORY CHAIN	75	12
2192	12	461 1966 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 115(1):112-& FRENKEL R REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE OSCILLATIONS IN CELL-FREE EXTRACTS FROM BEEF HEART	22	12
2193	3	477 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 25(1):133-& MARGOLIS SA; BAUM H; LENAZ G OBSERVATIONS ON EFFECT OF D2O ON ENERGY-LINKED REACTIONS OF MITOCHONDRION	32	12
2194	12	674 1967 IEEE SPECTRUM 4(8):79-& CHANCE B; PYE K; HIGGINS J WAVEFORM GENERATION BY ENZYMATIC OSCILLATORS	37	12
2195	3	714 1967 NATURE 215(5103):824-& GARBETT K; GILLARD RD; KNOWLES PF; STRANGRO.JE COTTON EFFECTS IN PLANT FERREDOXIN AND XANTHINE OXIDASE	57	12
2196	8	1018 1969 BIOCHEMISTRY 8(7):2987-& YOUNG DG; HALL PF SIDE-CHAIN CLEAVAGE OF CHOLESTEROL AND CHOLESTEROL SULFATE BY ENZYMES FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	40	12
2197	3	1021 1969 BIOCHEMISTRY 8(10):4027-& KIMURA T; SUZUKI K; PADMANAB.R; SAMEJIMA T; TARUTANI O; UI N STUDIES ON STEROID HYDROXYLASE . MOLECULAR PROPERTIES OF ADRENAL IRON-SULFUR PROTEIN	33	12
2198	3	1071 1969 EUROPEAN JOURNAL OF BIOCHEMISTRY 11(1):89-& RODER A; BAYER E ELECTRON SPIN RESONANCE IN HEMIN-MERCAPTAN COMPLEXES	32	12
2199	4	1115 1969 JOURNAL OF BIOLOGICAL CHEMISTRY 244(10):2767-& CHEN WL; CHARALAM.FC MECHANISM OF INDUCTION OF CYTOCHROME OXIDASE IN YEAST .I. KINETICS OF INDUCTION AND EVIDENCE FOR ACCUMULATION OF CYTOPLASMIC AND MITOCHONDRIAL PRECURSORS	86	12
2200	4	1122 1969 JOURNAL OF CELL BIOLOGY 41(2):441-& OHKAWA KI; VOGT MT; FARBER E UNUSUALLY HIGH MITOCHONDRIAL ALPHA GLYCEROPHOSPHATE DEHYDROGENASE ACTIVITY IN RAT BROWN ADIPOSE TISSUE	30	12

#	Cited nodes	Nodes / Authors	GCS	LCS
2201	12	1159 1969 PLANT PHYSIOLOGY 44(1):115-& STOREY BT; BAHR JT RESPIRATORY CHAIN OF PLANT MITOCHONDRIA .I. ELECTRON TRANSPORT BETWEEN SUCCINATE AND OXYGEN IN SKUNK CABBAGE MITOCHONDRIA	67	12
2202	6	1207 1970 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 38(2):184-& YOUNG DG; HOLROYD JD; HALL PF ENZYMATIC AND SPECTRAL PROPERTIES OF SOLUBILIZED CYTOCHROME P- 450 FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	14	12
2203	8	1234 1970 BIOCHEMICAL PHARMACOLOGY 19(5):1695-& TOPHAM JC RELATIONSHIP BETWEEN DIFFERENCE SPECTRA AND METABOLISM - BARBITURATES, DRUG INTERACTION AND SPECIES DIFFERENCE	23	12
2204	7	1243 1970 BIOCHEMICAL PHARMACOLOGY 19(8):2461-& CASTRO JA; GREENE FE; GIGON P; SASAME H; GILLETTE JR EFFECT OF ADRENALECTOMY AND CORTISONE ADMINISTRATION ON COMPONENTS OF LIVER MICROSOMAL MIXED FUNCTION OXYGENASE SYSTEM OF MALE RATS WHICH CATALYZES ETHYLMORPHINE METABOLISM	55	12
2205	8	1377 1970 LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY 9(18):1033-& HOLTZMAN JL; CARR ML INHIBITION OF HEPATIC MICROSOMAL MIXED FUNCTION OXIDASES BY D2O	13	12
2206	5	1426 1971 ANESTHESIOLOGY 35(3):241-& BROWN BR DIPHASIC ACTION OF HALOTHANE ON OXIDATIVE METABOLISM OF DRUGS BY LIVER - IN-VITRO STUDY IN RAT	49	12
2207	5	1479 1971 BIOCHEMICAL JOURNAL 123(5):815-& SLATER TF; SAWYER BC STIMULATORY EFFECTS OF CARBON TETRACHLORIDE ON PEROXIDATIVE REACTIONS IN RAT LIVER FRACTIONS IN-VITRO - INTERACTION SITES IN ENDOPLASMIC RETICULUM	84	12
2208	5	1591 1971 FEBS LETTERS 15(3):209-& SATO N; WILSON DF; CHANCE B 2 B-CYTOCHROMES OF PIGEON HEART MITOCHONDRIA	38	12
2209	2	1615 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(3):791-& LODE ET; COON MJ ENZYMATIC OMEGA-OXIDATION .5. FORMS OF PSEUDOMONAS-OLEOVORANS RUBREDOXIN CONTAINING ONE OR 2 IRON ATOMS - STRUCTURE AND FUNCTION IN OMEGA-HYDROXYLATION	90	12
2210	2	1649 1971 JOURNAL OF NEUROPHYSIOLOGY 34(5):735-& JOBSIS FF; OCONNOR M; VITALE A; VREMAN H INTRACELLULAR REDOX CHANGES IN FUNCTIONING CEREBRAL CORTEX .1. METABOLIC EFFECTS OF EPILEPTIFORM ACTIVITY	175	12
2211	7	1661 1971 LIFE SCIENCE PART 1 PHYSIOLOGY & PHARMACOLOGY 10(12):669-& HOLTZMAN JL; RUMACK BH KINETICS OF CYTOCHROME P-450 REDUCTASE STIMULATION BY ETHYLMORPHINE	17	12
2212	11	1790 1972 BIOCHEMICAL PHARMACOLOGY 21(10):1377-& ZANNONI VG; FLYNN EJ; LYNCH M ASCORBIC-ACID AND DRUG-METABOLISM	128	12
2213	10	1810 1972 BIOCHEMISTRY 11(7):1150-& BRANDON JR; BROCKLEH.JR; LEE CP EFFECT OF ANTIMYCIN A AND 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE ON RESPIRATORY CHAIN OF SUBMITOCHONDRIAL PARTICLES OF BEEF HEART	69	12
2214	13	1928 1972 JOURNAL OF BIOLOGICAL CHEMISTRY 247(7):2109-& UEDA T; LODE ET; COON MJ ENZYMATIC OMEGA-OXIDATION .6. ISOLATION OF HOMOGENEOUS REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE-RUBREDOXIN REDUCTASE	80	12
2215	3	2089 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 55(3):937-944 MOLDEUS P; GRUNDIN R; BAHR CV; ORRENIUS S SPECTRAL STUDIES ON DRUG-CYTOCHROME P-450 INTERACTION IN ISOLATED RAT-LIVER CELLS	30	12
2216	8	2093 1973 BIOCHEMICAL JOURNAL 136(2):371-379 ARCHAKOV AI; KARUZINA II; KOKAREVA IS; BACHMANO.GI EFFECT OF MAGNESIUM IONS ON DIMETHYLANILINE OXIDATION RATE AND ELECTRON-TRANSFER IN LIVER MICROSOMAL FRACTION	27	12
2217	19	2134 1973 BIOCHIMICA ET BIOPHYSICA ACTA 301(2):129-154 SLATER EC MECHANISM OF ACTION OF RESPIRATORY INHIBITOR, ANTIMYCIN	199	12
2218	11	2206 1973 DRUG METABOLISM AND DISPOSITION 1(1):299-313 UEHLEKE H ROLE OF CYTOCHROME-P-450 IN N-OXIDATION OF INDIVIDUAL AMINES	62	12
2219	13	2214 1973 DRUG METABOLISM AND DISPOSITION 1(5):663-668 SITAR DS; MANNERIN.GJ DETERMINATION OF APPARENT KINETIC CONSTANTS OF MICROSOMAL HYDROXYLATION OF AMOBARBITAL, HEXOBARBITAL, AND PENTOBARBITAL	20	12
2220	4	2510 1974 ENDOCRINOLOGY 94(5):1286-1294 TAUROG A; DORRIS ML; LAMAS L COMPARISON OF LACTOPEROXIDASE- AND THYROID PEROXIDASE-CATALYZED IODINATION AND COUPLING	70	12
2221	4	2550 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(8):2528-2535 BJORKHEM I; GUSTAFSS.J MITOCHONDRIAL OMEGA-HYDROXYLATION OF CHOLESTEROL SIDE-CHAIN	90	12
2222	13	2763 1975 CANCER RESEARCH 35(8):2083-2091 VADI H; MOLDEUS P; CAPDEVILA J; ORRENIUS S METABOLISM OF BENZO(ALPHA-)PYRENE IN ISOLATED RAT-LIVER CELLS	63	12
2223	14	2854 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(18):7397-7404 TESCHKE R; HASUMURA Y; LIEBER CS HEPATIC MICROSOMAL ALCOHOL-OXIDIZING SYSTEM - AFFINITY FOR METHANOL, ETHANOL, PROPANOL, AND BUTANOL	104	12
2224	6	2983 1976 BIOCHEMICAL JOURNAL 157(1):237-246 BERMAN MC; ADNAMS CM; IVANETICH KM; KENCH JE AUTOXIDATION OF SOLUBLE TRYPSIN-CLEAVED MICROSOMAL FERROCYTOCHROME B-5 AND FORMATION OF SUPEROXIDE RADICALS	25	12
2225	9	2998 1976 BIOCHEMICAL PHARMACOLOGY 25(9):997-1005 LENK W APPLICATION AND INTERPRETATION OF KINETIC ANALYSES FROM MICROSOMAL DRUG-METABOLIZING OXYGENASES	37	12
2226	12	3013 1976 BIOCHIMICA ET BIOPHYSICA ACTA 421(1):44-56 TSYRLOV IB; ZAKHAROVA NE; GROMOVA OA; LYAKHOVICH VV POSSIBLE MECHANISM OF INDUCTION OF LIVER MICROSOMAL MONOOXYGENASES BY PHENOBARBITAL	42	12
2227	26	3047 1976 CHEMICO-BIOLOGICAL INTERACTIONS 14(3-4):337-346 FRANKLIN MR NEW CLASS OF INHIBITORY CYTOCHROME-P-450 COMPLEXES FORMED DURING METABOLISM - COMPARISON WITH AMPHETAMINE AND SKF 525-A TYPE COMPLEXES	21	12
2228	31	3070 1976 DRUG METABOLISM REVIEWS 5(1):1-42 SHORT CR; KINDEN DA; STITH R FETAL AND NEONATAL DEVELOPMENT OF MICROSOMAL MONOOXYGENASE SYSTEM	128	12
2229	11	3404 1977 JOURNAL OF BIOLOGICAL CHEMISTRY 252(24):8788-8796 JEFCOATE CR CYTOCHROME-P-450 OF ADRENAL MITOCHONDRIA - STEROID BINDING- SITES ON 2 DISTINGUISHABLE FORMS OF RAT ADRENAL MITOCHONDRIAL CYTOCHROME-P-450SCC	37	12
2230	3	3450 1977 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74(9):3725-3729 OZOLS J; GERARD C PRIMARY STRUCTURE OF MEMBRANOUS SEGMENT OF CYTOCHROME-B5 - (HYDROPHOBIC PEPTIDES ISOLATION SEQUENCER ANALYSIS TRYPTOPHANYL CLEAVAGE SECONDARY STRUCTURE)	87	12
2231	10	3467 1977 ZEITSCHRIFT FUR KREBSFORSCHUNG UND KLINISCHE ONKOLOGIE 89(2):181-199 ARCOS JC; DAVIES DL; BROWN CEL; ARGUS MF REPRESSIBLE AND INDUCIBLE ENZYMIC FORMS OF DIMETHYLNITROSAMINE- DEMETHYLASE	107	12
2232	5	3497 1978 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 81(2):672-679 PAINE AJ; LEGG RF APPARENT LACK OF CORRELATION BETWEEN LOSS OF CYTOCHROME-P-450 IN HEPATIC PARENCHYMAL-CELL CULTURE AND STIMULATION OF HEME OXYGENASE ACTIVITY	112	12
2233	8	3504 1978 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 85(3):859-866 BRADSHAW JJ; ZIMAN MR; IVANETICH KM DEGRADATION OF DIFFERENT FORMS OF CYTOCHROME-P-450 INVIVO BY FLUROXENE AND ALLYL-ISO-PROPYLACETAMIDE	30	12
2234	21	3523 1978 BIOCHEMICAL PHARMACOLOGY 27(8):1229-1237 MANSUY D; ROUER E; BACOT C; GANS P; CHOTTARD JC; LEROUX JP INTERACTION OF ALIPHATIC N-HYDROXYLAMINES WITH MICROSOMAL CYTOCHROME P450 - NATURE OF DIFFERENT DERIVED COMPLEXES AND INHIBITORY EFFECTS ON MONOXYGENASES ACTIVITIES	38	12
2235	10	3638 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(21):7952-7959 COLE ES; LEPP CA; HOLOHAN PD; FONDY TP ISOLATION AND CHARACTERIZATION OF FLAVIN-LINKED GLYCEROL-3- PHOSPHATE DEHYDROGENASE FROM RABBIT SKELETAL-MUSCLE MITOCHONDRIA AND COMPARISON WITH ENZYME FROM RABBIT BRAIN	29	12
2236	11	3642 1978 JOURNAL OF CELL BIOLOGY 78(2):503-519 MATSUURA S; FUJIIKURIYAMA Y; TASHIRO Y IMMUNOELECTRON MICROSCOPE LOCALIZATION OF CYTOCHROME-P-450 ON MICROSOMES AND OTHER MEMBRANE STRUCTURES OF RAT HEPATOCYTES	74	12
2237	5	3749 1979 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 86(3):710-717 SINCLAIR JF; SINCLAIR PR; BONKOWSKY HL HORMONAL REQUIREMENTS FOR THE INDUCTION OF CYTOCHROME-P450 IN HEPATOCYTES CULTURED IN A SERUM-FREE MEDIUM	82	12
2238	4	3827 1979 DRUG METABOLISM AND DISPOSITION 7(5):260-262 RICE SA; TALCOTT RE EFFECTS OF ISONIAZID TREATMENT ON SELECTED HEPATIC MIXED- FUNCTION OXIDASES	69	12
2239	14	3882 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(11):4331-4334 OFTEBRO H; STORMER FC; PEDERSEN JI PRESENCE OF AN ADRENODOXIN-LIKE FERREDOXIN AND CYTOCHROME-P-450 IN BRAIN MITOCHONDRIA	31	12
2240	12	3887 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(15):7238-7246 SWANSON RA; DUS KM SPECIFIC COVALENT LABELING OF CYTOCHROME P-450CAM WITH 1-(4- AZIDOPHENYL)IMIDAZOLE, AN INHIBITOR-DERIVED PHOTOAFFINITY PROBE FOR P-450 HEME-PROTEINS	28	12
2241	29	3889 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(17):8377-8385 KIDO T; ARAKAWA M; KIMURA T ADRENAL-CORTEX MITOCHONDRIAL CYTOCHROME-P-450 SPECIFIC TO CHOLESTEROL SIDE-CHAIN CLEAVAGE REACTION - SPECTRAL CHANGES INDUCED BY DETERGENTS, ALCOHOLS, AMINES, PHOSPHOLIPIDS, STEROID HYDROXYLASE INHIBITORS, AND STEROID SUBSTRATES, AND CONDITIONS FOR ADRENODOXIN BINDING TO THE CYTOCHROME	50	12
2242	12	3906 1979 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 208(2):271-279 MARIETTA MP; VESELL ES; HARTMAN RD; WEISZ J; DVORCHIK BH CHARACTERIZATION OF CYTOCHROME P-450-DEPENDENT AMINOPYRINE N- DEMETHYLASE IN RAT-BRAIN - COMPARISON WITH HEPATIC AMINOPYRINE N-DEMETHYLATION	86	12
2243	10	3925 1979 MOLECULAR PHARMACOLOGY 15(3):719-728 GUENTHNER TM; NEBERT DW; MENARD RH MICROSOMAL ARYL-HYDROCARBON HYDROXYLASE IN RAT ADRENAL - REGULATION BY ACTH BUT NOT BY POLYCYCLIC-HYDROCARBONS	47	12
2244	91	3941 1979 PHARMACOLOGY & THERAPEUTICS 7(2):203-244 SNYDER R; REMMER H CLASSES OF HEPATIC MICROSOMAL MIXED-FUNCTION OXIDASE INDUCERS	80	12
2245	13	4214 1980 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES 77(3):1240-1244 SLIGAR SG; KENNEDY KA; PEARSON DC CHEMICAL MECHANISMS FOR CYTOCHROME-P-450 HYDROXYLATION - EVIDENCE FOR ACYLATION OF HEME-BOUND DIOXYGEN	72	12
2246	12	4293 1981 BIOCHEMICAL PHARMACOLOGY 30(12):1651-1658 MUAKKASSAH SF; BIDLACK WR; YANG WCT MECHANISM OF THE INHIBITORY-ACTION OF ISONIAZID ON MICROSOMAL DRUG-METABOLISM	32	12
2247	5	4517 1982 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 108(2):664-672 HAJEK KK; NOVAK RF SPECTRAL AND METABOLIC PROPERTIES OF LIVER-MICROSOMES FROM IMIDAZOLE-PRETREATED RABBITS	35	12
2248	12	4550 1982 BIOCHEMISTRY 21(10):2499-2507 WAXMAN DJ; LIGHT DR; WALSH C CHIRAL SULFOXIDATIONS CATALYZED BY RAT-LIVER CYTOCHROMES P-450	99	12
2249	5	4782 1983 BIOCHEMICAL PHARMACOLOGY 32(5):831-835 REILLY PEB; CARRINGTON LE; WINZOR DJ THE INTERACTION OF CIMETIDINE WITH RAT-LIVER MICROSOMES	54	12
2250	6	4917 1983 JOURNAL OF BIOLOGICAL CHEMISTRY 258(12):7311-7316 JOHANSSON I; INGELMANSUNDBERG M HYDROXYL RADICAL-MEDIATED, CYTOCHROME-P-450-DEPENDENT METABOLIC-ACTIVATION OF BENZENE IN MICROSOMES AND RECONSTITUTED ENZYME-SYSTEMS FROM RABBIT LIVER	60	12
2251	1	4936 1983 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 226(3):790-795 SINGER HA; PEACH MJ ENDOTHELIUM-DEPENDENT RELAXATION OF RABBIT AORTA .1. RELAXATION STIMULATED BY ARACHIDONIC-ACID	110	12
2252	6	4946 1983 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 105(5):1399-1401 BATTIONI P; MAHY JP; GILLET G; MANSUY D IRON PORPHYRIN DEPENDENT OXIDATION OF METHYLHYDRAZINE AND PHENYLHYDRAZINE - ISOLATION OF IRON(II)-DIAZENE AND SIGMA- ALKYLIRON(III) (OR ARYLIRON(III)) COMPLEXES - RELEVANCE TO THE REACTIONS OF HEMOPROTEINS WITH HYDRAZINES	45	12
2253	14	5069 1984 BIOCHEMISTRY 23(22):5300-5306 RUF HH; AHR H; NASTAINCZYK W; ULLRICH V; MANSUY D; BATTIONI JP; MONTIELMONTOYA R; TRAUTWEIN A FORMATION OF A FERRIC CARBANION COMPLEX FROM HALOTHANE AND CYTOCHROME-P-450 - ELECTRON-SPIN RESONANCE, ELECTRONIC-SPECTRA, AND MODEL COMPLEXES	34	12
2254	7	5172 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(5):3275-3282 HACKETT CS; STRITTMATTER P COVALENT CROSS-LINKING OF THE ACTIVE-SITES OF VESICLE-BOUND CYTOCHROME-B5 AND NADH-CYTOCHROME-B5 REDUCTASE	41	12
2255	3	5188 1984 JOURNAL OF LIPID RESEARCH 25(5):507-517 VANROLLINS M; MURPHY RC AUTOOXIDATION OF DOCOSAHEXAENOIC ACID - ANALYSIS OF 10 ISOMERS OF HYDROXYDOCOSAHEXAENOATE	43	12
2256	12	5235 1984 TETRAHEDRON LETTERS 25(23):2443-2446 FALCK JR; MANNA S; CAPDEVILA J ENANTIOSPECIFIC SYNTHESIS OF METHYL 11,12-EPOXYEICOSATRIENOATE AND 14,15-EPOXYEICOSATRIENOATE	19	12
2257	12	5243 1984 TRENDS IN BIOCHEMICAL SCIENCES 9(9):393-396 TAKEMORI S; KOMINAMI S THE ROLE OF CYTOCHROMES-P-450 IN ADRENAL STEROIDOGENESIS	61	12
2258	12	5549 1986 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 251(2):471-478 MURRAY M; ZALUZNY L; FARRELL GC SELECTIVE REACTIVATION OF STEROID HYDROXYLASES FOLLOWING DISSOCIATION OF THE ISOSAFROLE METABOLITE COMPLEX WITH RAT HEPATIC CYTOCHROME-P-450	27	12
2259	6	5560 1986 BIOCHEMICAL PHARMACOLOGY 35(6):883-891 BEETENS JR; LOOTS W; SOMERS Y; COENE MC; DECLERCK F KETOCONAZOLE INHIBITS THE BIOSYNTHESIS OF LEUKOTRIENES INVITRO AND INVIVO	106	12
2260	11	5740 1986 TRENDS IN PHARMACOLOGICAL SCIENCES 7(7):266-270 BAST A IS FORMATION OF REACTIVE OXYGEN BY CYTOCHROME-P-450 PERILOUS AND PREDICTABLE	39	12
2261	13	5777 1987 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 145(3):1239-1247 NONAKA Y; MURAKAMI H; YABUSAKI Y; KURAMITSU S; KAGAMIYAMA H; YAMANO T; OKAMOTO M MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF FULL-LENGTH CDNA FOR MESSENGER-RNA OF ADRENODOXIN OXIDOREDUCTASE FROM BOVINE ADRENAL-CORTEX	27	12
2262	10	5986 1987 TOXICOLOGY AND APPLIED PHARMACOLOGY 90(1):69-78 VOORMAN R; AUST SD SPECIFIC BINDING OF POLYHALOGENATED AROMATIC HYDROCARBON INDUCERS OF CYTOCHROME P-450D TO THE CYTOCHROME AND INHIBITION OF ITS ESTRADIOL 2-HYDROXYLASE ACTIVITY	93	12
2263	4	6009 1988 AMERICAN JOURNAL OF HUMAN GENETICS 42(1):4-7 MILLER WL GENE CONVERSIONS, DELETIONS, AND POLYMORPHISMS IN CONGENITAL ADRENAL-HYPERPLASIA	34	12
2264	11	6044 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 267(2):589-598 HONKAKOSKI P; AUTIO S; JUVONEN R; RAUNIO H; GELBOIN HV; PARK SS; PELKONEN O; LANG MA PYRAZOLE IS DIFFERENT FROM ACETONE AND ETHANOL AS AN INDUCER OF THE POLYSUBSTRATE MONOOXYGENASE SYSTEM IN MICE - EVIDENCE THAT PYRAZOLE-INDUCIBLE P450COH IS DISTINCT FROM ACETONE-INDUCIBLE P450AC	22	12
2265	4	6049 1988 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 150(1):10-17 KHANI SC; PORTER TD; COON MJ ISOLATION AND PARTIAL CHARACTERIZATION OF THE GENE FOR CYTOCHROME-P-450 3A (P-450ALC) AND A 2ND CLOSELY RELATED GENE	13	12
2266	7	6114 1988 BIOCHEMISTRY 27(15):5461-5470 SWINNEY DC; RYAN DE; THOMAS PE; LEVIN W EVIDENCE FOR CONCERTED KINETIC OXIDATION OF PROGESTERONE BY PURIFIED RAT HEPATIC CYTOCHROME-P-450G	21	12
2267	3	6147 1988 CANCER RESEARCH 48(21):5937-5940 BRADY JF; LI D; ISHIZAKI H; YANG CS EFFECT OF DIALLYL SULFIDE ON RAT-LIVER MICROSOMAL NITROSAMINE METABOLISM AND OTHER MONOOXYGENASE ACTIVITIES	139	12
2268	3	6185 1988 DRUG METABOLISM AND DISPOSITION 16(2):296-301 FABRE I; FABRE G; MAUREL P; BERTAULTPERES P; CANO JP METABOLISM OF CYCLOSPORIN-A .3. INTERACTION OF THE MACROLIDE ANTIBIOTIC, ERYTHROMYCIN, USING RABBIT HEPATOCYTES AND MICROSOMAL FRACTIONS	36	12
2269	5	6327 1988 TOXICOLOGY LETTERS 44(3):289-297 LONGO V; CITTI L; GERVASI PG BIOTRANSFORMATION ENZYMES IN NASAL-MUCOSA AND LIVER OF SPRAGUE- DAWLEY RATS	36	12
2270	5	6375 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 270(1):23-32 OESCH F; WAXMAN DJ; MORRISSEY JJ; HONSCHA W; KISSEL W; FRIEDBERG T ANTIBODIES TARGETED AGAINST HYPERVARIABLE AND CONSTANT REGIONS OF CYTOCHROME-P450IIB1 AND CYTOCHROME-P450IIB2	14	12
2271	2	6406 1989 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 160(1):276-281 CHUNG BC; HU MC; LAI CC; LIN CH THE 5'-REGION OF THE P450XIA1 (P450SCC) GENE CONTAINS A BASAL PROMOTER AND AN ADRENAL-SPECIFIC ACTIVATING DOMAIN	31	12
2272	7	6463 1989 BIOCHEMISTRY 28(12):5128-5136 DECKER CJ; RASHED MS; BAILLIE TA; MALTBY D; CORREIA MA OXIDATIVE-METABOLISM OF SPIRONOLACTONE - EVIDENCE FOR THE INVOLVEMENT OF ELECTROPHILIC THIOSTEROID SPECIES IN DRUG- MEDIATED DESTRUCTION OF RAT HEPATIC CYTOCHROME-P450	27	12
2273	4	6598 1989 FEBS LETTERS 256(1-2):128-134 SANGLARD D; FIECHTER A HETEROGENEITY WITHIN THE ALKANE-INDUCIBLE CYTOCHROME-P450 GENE FAMILY OF THE YEAST CANDIDA-TROPICALIS	16	12
2274	3	6606 1989 GENE 80(2):353-361 TOMATSU S; KOBAYASHI Y; FUKUMAKI Y; YUBISUI T; ORII T; SAKAKI Y THE ORGANIZATION AND THE COMPLETE NUCLEOTIDE-SEQUENCE OF THE HUMAN NADH-CYTOCHROME B5 REDUCTASE GENE	70	12
2275	7	6664 1989 JOURNAL OF ENDOCRINOLOGY 120(2):311-317 MODE A; WIERSMALARSSON E; STROM A; ZAPHIROPOULOS PG; GUSTAFSSON JA A DUAL ROLE OF GROWTH-HORMONE AS A FEMINIZING AND MASCULINIZING FACTOR IN THE CONTROL OF SEX-SPECIFIC CYTOCHROME-P-450 ISOZYMES IN RAT-LIVER	39	12
2276	5	6688 1989 MARINE ENVIRONMENTAL RESEARCH 27(1):31-50 ELSKUS AA; STEGEMAN JJ INDUCED CYTOCHROME-P-450 IN FUNDULUS-HETEROCLITUS ASSOCIATED WITH ENVIRONMENTAL CONTAMINATION BY POLYCHLORINATED-BIPHENYLS AND POLYNUCLEAR AROMATIC-HYDROCARBONS	32	12
2277	9	6711 1989 MOLECULAR PHARMACOLOGY 35(5):610-616 LORR NA; BLOOM SE; PARK SS; GELBOIN HV; MILLER H; FRIEDMAN FK EVIDENCE FOR A PCN-P450 ENZYME IN CHICKENS AND COMPARISON OF ITS DEVELOPMENT WITH THAT OF OTHER PHENOBARBITAL-INDUCIBLE FORMS	28	12
2278	3	6757 1989 PROSTAGLANDINS 38(6):615-624 PATEL L; SULLIVAN MHF; ELDER MG PRODUCTION OF EPOXYGENASE METABOLITE BY HUMAN REPRODUCTIVE TISSUES	29	12
2279	3	6854 1990 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 167(1):137-142 PRITCHARD KA; TOTA RR; STEMERMAN MB; WONG PYK 14,15-EPOXYEICOSATRIENOIC ACID PROMOTES ENDOTHELIAL-CELL DEPENDENT ADHESION OF HUMAN MONOCYTIC TUMOR U937 CELLS	29	12
2280	14	6957 1990 CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 68(6):762-768 BANDIERA S EXPRESSION AND CATALYSIS OF SEX-SPECIFIC CYTOCHROME-P450 ISOZYMES IN RAT-LIVER	23	12
2281	9	6981 1990 CARCINOGENESIS 11(8):1259-1263 VANG O; JENSEN MB; AUTRUP H INDUCTION OF CYTOCHROME P450IA1 IN RAT COLON AND LIVER BY INDOLE-3-CARBINOL AND 5,6-BENZOFLAVONE	56	12
2282	7	7005 1990 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 96(2):259-270 KLEINOW KM; HAASCH ML; WILLIAMS DE; LECH JJ A COMPARISON OF HEPATIC-P450 INDUCTION IN RAT AND TROUT (ONCORHYNCHUS-MYKISS) - DELINEATION OF THE SITE OF RESISTANCE OF FISH TO PHENOBARBITAL-TYPE INDUCERS	44	12
2283	17	7013 1990 DNA AND CELL BIOLOGY 9(6):425-436 PUGA A; RAYCHAUDHURI B; SALATA K; ZHANG YH; NEBERT DW STABLE EXPRESSION OF MOUSE CYPLAL AND HUMAN CYP1A2 CDNAS TRANSFECTED INTO MOUSE HEPATOMA-CELLS LACKING DETECTABLE P450 ENZYME-ACTIVITY	30	12
2284	14	7255 1990 NUCLEIC ACIDS RESEARCH 18(6):1429-1434 HASSETT C; OMIECINSKI CJ SEQUENCE AND GENE-EXPRESSION OF RABBIT CYTOCHROME P450 IIC16 - COMPARISON TO HIGHLY RELATED FAMILY MEMBERS	18	12
2285	7	7285 1990 PROTEIN ENGINEERING 3(7):571-575 HANIOKA N; KORZEKWA K; GONZALEZ FJ SEQUENCE REQUIREMENTS FOR CYTOCHROMES P450IIA1 AND P450IIA2 CATALYTIC ACTIVITY - EVIDENCE FOR BOTH SPECIFIC AND NONSPECIFIC SUBSTRATE BINDING INTERACTIONS THROUGH USE OF CHIMERIC CDNAS AND CDNA EXPRESSION	18	12
2286	6	7337 1991 AGRICULTURAL AND BIOLOGICAL CHEMISTRY 55(7):1757-1764 OHKUMA M; HIKIJI T; TANIMOTO T; SCHUNCK WH; MULLER HG; YANO K; TAKAGI M EVIDENCE THAT MORE THAN ONE GENE ENCODES NORMAL-ALKANE- INDUCIBLE CYTOCHROME-P-450S IN CANDIDA-MALTOSA, FOUND BY 2-STEP GENE DISRUPTION	22	12
2287	19	7506 1991 CLINICAL PHARMACOKINETICS 21(3):195-212 ANDERSSON T OMEPRAZOLE DRUG-INTERACTION STUDIES	93	12
2288	10	7511 1991 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 98(1):97-103 ZHANG YS; GOKSOYR A; ANDERSSON T; FORLIN L INITIAL PURIFICATION AND CHARACTERIZATION OF HEPATIC-MICROSOMAL CYTOCHROME-P-450 FROM BNF-TREATED PERCH (PERCA-FLUVIATILIS)	14	12
2289	10	7559 1991 EUROPEAN JOURNAL OF BIOCHEMISTRY 198(2):307-315 OUZOUNIS CA; MELVIN WT PRIMARY AND SECONDARY STRUCTURAL PATTERNS IN EUKARYOTIC CYTOCHROME-P-450 FAMILIES CORRESPOND TO STRUCTURES OF THE HELIX-RICH DOMAIN OF PSEUDOMONAS-PUTIDA CYTOCHROME-P-450CAM - INDICATIONS FOR A SIMILAR OVERALL TOPOLOGY	19	12
2290	4	7767 1991 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88(21):9543-9547 BJELDANES LF; KIM JY; GROSE KR; BARTHOLOMEW JC; BRADFIELD CA AROMATIC HYDROCARBON RESPONSIVENESS-RECEPTOR AGONISTS GENERATED FROM INDOLE-3-CARBINOL INVITRO AND INVIVO - COMPARISONS WITH 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN	186	12
2291	9	7868 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 296(1):66-72 MUERHOFF AS; GRIFFIN KJ; JOHNSON EF CHARACTERIZATION OF A RABBIT GENE ENCODING A CLOFIBRATE- INDUCIBLE FATTY-ACID OMEGA-HYDROXYLASE - CYP4A6	19	12
2292	13	7966 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1139(4):275-279 YANASE T; WATERMAN MR; ZACHMANN M; WINTER JSD; SIMPSON ER; KAGIMOTO M MOLECULAR-BASIS OF APPARENT ISOLATED 17,20-LYASE DEFICIENCY - COMPOUND HETEROZYGOUS MUTATIONS IN THE C-TERMINAL REGION (ARG(496)-]CYS, GLN(461)-]STOP) ACTUALLY CAUSE COMBINED 17- ALPHA-HYDROXYLASE 17,20-LYASE DEFICIENCY	39	12
2293	6	8052 1992 DRUG METABOLISM AND DISPOSITION 20(3):367-373 SUZUKI T; NARIMATSU S; FUJITA S; MASUBUCHI Y; UMEDA S; IMAOKA S; FUNAE Y PURIFICATION AND CHARACTERIZATION OF A CYTOCHROME-P-450 ISOZYME CATALYZING BUNITROLOL 4-HYDROXYLATION IN LIVER-MICROSOMES OF MALE-RATS	42	12
2294	9	8062 1992 DRUG METABOLISM AND DISPOSITION 20(6):797-801 CORCOS L PHENOBARBITAL AND DEXAMETHASONE INDUCE EXPRESSION OF CYTOCHROME-P-450 GENES FROM SUBFAMILY-IIB, SUBFAMILY-IIC, AND SUBFAMILY-IIIA IN MOUSE-LIVER	35	12
2295	32	8064 1992 DRUG METABOLISM REVIEWS 24(2):195-238 JUCHAU MR; LEE QP; FANTEL AG XENOBIOTIC BIOTRANSFORMATION BIOACTIVATION IN ORGANOGENESIS- STAGE CONCEPTUAL TISSUES - IMPLICATIONS FOR EMBRYOTOXICITY AND TERATOGENESIS	64	12
2296	8	8078 1992 EUROPEAN JOURNAL OF BIOCHEMISTRY 205(1):303-309 TODA K; MIYAHARA K; KAWAMOTO T; IKEDA H; SAGARA Y; SHIZUTA Y CHARACTERIZATION OF A CIS-ACTING REGULATORY ELEMENT INVOLVED IN HUMAN-AROMATASE P-450 GENE-EXPRESSION	22	12
2297	14	8160 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(6):3686-3690 BERNSTROM K; KAYGANICH K; MURPHY RC; FITZPATRICK FA INCORPORATION AND DISTRIBUTION OF EPOXYEICOSATRIENOIC ACIDS INTO CELLULAR PHOSPHOLIPIDS	23	12
2298	14	8185 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(31):22587-22594 CHEN S; ZHOU DJ FUNCTIONAL DOMAINS OF AROMATASE CYTOCHROME-P450 INFERRED FROM COMPARATIVE ANALYSES OF AMINO-ACID-SEQUENCES AND SUBSTANTIATED BY SITE-DIRECTED MUTAGENESIS EXPERIMENTS	43	12
2299	1	8187 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(34):24173-24176 POU S; POU WS; BREDT DS; SNYDER SH; ROSEN GM GENERATION OF SUPEROXIDE BY PURIFIED BRAIN NITRIC-OXIDE SYNTHASE	406	12
2300	9	8196 1992 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 74(3):667-672 AHLGREN R; YANASE T; SIMPSON ER; WINTER JSD; WATERMAN MR COMPOUND HETEROZYGOUS MUTATIONS (ARG 239-]STOP, PRO 342-]THR) IN THE CYP17 (P45017-ALPHA) GENE LEAD TO AMBIGUOUS EXTERNAL GENITALIA IN A MALE-PATIENT WITH PARTIAL COMBINED 17-ALPHA- HYDROXYLASE 17,20-LYASE DEFICIENCY	36	12

#	Cited nodes	Nodes / Authors	GCS	LCS
2301	7	8264 1992 MOLECULAR AND CELLULAR BIOLOGY 12(6):2847-2854 YANO M; FALVEY E; GONZALEZ FJ ROLE OF THE LIVER-ENRICHED TRANSCRIPTION FACTOR DBP IN EXPRESSION OF THE CYTOCHROME P450 CYP2C6 GENE	39	12
2302	15	8301 1992 PHARMACOLOGY & TOXICOLOGY 71(4):258-261 HORSMANS Y; DESAGER JP; HARVENGT C ABSENCE OF CYP3A GENETIC-POLYMORPHISM ASSESSED BY URINARY- EXCRETION OF 6-BETA-HYDROXYCORTISOL IN 102 HEALTHY-SUBJECTS ON RIFAMPICIN	26	12
2303	15	8365 1993 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 17(4):900-905 LUCAS D; BERTHOU F; DREANO Y; LOZACH P; VOLANT A; MENEZ JF COMPARISON OF LEVELS OF CYTOCHROMES-P-450, CYP1A2, CYP2E1, AND THEIR RELATED MONOOXYGENASE ACTIVITIES IN HUMAN SURGICAL LIVER SAMPLES	44	12
2304	25	8375 1993 ANESTHESIA AND ANALGESIA 76(5):1033-1039 KHARASCH ED; THUMMEL KE HUMAN ALFENTANIL METABOLISM BY CYTOCHROME-P450-3A3/4 - AN EXPLANATION FOR THE INTERINDIVIDUAL VARIABILITY IN ALFENTANIL CLEARANCE	49	12
2305	12	8393 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 300(1):401-408 RASHBASTEP J; TURRO NJ; CEDERBAUM AI INCREASED NADPH-DEPENDENT AND NADH-DEPENDENT PRODUCTION OF SUPEROXIDE AND HYDROXYL RADICAL BY MICROSOMES AFTER CHRONIC ETHANOL TREATMENT	58	12
2306	14	8436 1993 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 196(2):721-728 KOMORI M A NOVEL P450 EXPRESSED AT THE HIGH-LEVEL IN RAT-BRAIN	31	12
2307	33	8468 1993 BIOCHEMICAL PHARMACOLOGY 45(11):2239-2250 ROOS PH; GOLUBCIOSK B; KALLWEIT P; KAUCZINSKI D; HANSTEIN WG FORMATION OF LIGAND AND METABOLITE COMPLEXES AS A MEANS FOR SELECTIVE QUANTITATION OF CYTOCHROME-P450 ISOZYMES	28	12
2308	11	8508 1993 BIOCHIMICA ET BIOPHYSICA ACTA 1158(3):227-236 OHISHI N; IMAOKA S; SUZUKI T; FUNAE Y CHARACTERIZATION OF 2 P-450 ISOZYMES PLACED IN THE RAT CYP2D SUBFAMILY	31	12
2309	6	8652 1993 HYPERTENSION 22(3):357-364 IMIG JD; FALCK JR; GEBREMEDHIN D; HARDER DR; ROMAN RJ ELEVATED RENOVASCULAR TONE IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS - ROLE OF CYTOCHROME-P-450	55	12
2310	18	8667 1993 JOURNAL OF BIOCHEMICAL TOXICOLOGY 8(3):135-144 OKITA JR; CASTLE PJ; OKITA RT CHARACTERIZATION OF CYTOCHROMES-P450 IN LIVER AND KIDNEY OF RATS TREATED WITH DI-(2-ETHYLHEXYL)PHTHALATE	35	12
2311	8	8695 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(24):18267-18271 KOH YC; BUCZKO E; DUFAU ML REQUIREMENT OF PHENYLALANINE-343 FOR THE PREFERENTIAL DELTA-4- LYASE VERSUS DELTA-5-LYASE ACTIVITY OF RAT CYP17	25	12
2312	6	8698 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(28):21399-21402 SHIMOZAWA O; SAKAGUCHI M; OGAWA H; HARADA N; MIHARA K; OMURA T CORE GLYCOSYLATION OF CYTOCHROME-P-450 (AROM) - EVIDENCE FOR LOCALIZATION OF N-TERMINUS OF MICROSOMAL CYTOCHROME-P-450 IN THE LUMEN	37	12
2313	10	8741 1993 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 44(4-6):321-330 SIMPSON ER; MAHENDROO MS; MEANS GD; KILGORE MW; CORBIN CJ; MENDELSON CR TISSUE-SPECIFIC PROMOTERS REGULATE AROMATASE CYTOCHROME-P450 EXPRESSION	47	12
2314	7	8784 1993 MOLECULAR PHARMACOLOGY 44(3):560-568 STERLING K; WEAVER J; HO KL; XU LC; BRESNICK E RAT CYP1A1 NEGATIVE REGULATORY ELEMENT - BIOLOGICAL-ACTIVITY AND INTERACTION WITH A PROTEIN FROM LIVER AND HEPATOMA-CELLS	36	12
2315	10	8785 1993 MOLECULAR PHARMACOLOGY 44(4):775-783 SHAW PM; ADESNIK M; WEISS MC; CORCOS L THE PHENOBARBITAL-INDUCED TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME-P-450 GENES IS BLOCKED BY THE GLUCOCORTICOID- PROGESTERONE ANTAGONIST RU486	40	12
2316	5	8823 1993 PLANT MOLECULAR BIOLOGY 23(5):933-946 TOGURI T; UMEMOTO N; KOBAYASHI O; OHTANI T ACTIVATION OF ANTHOCYANIN SYNTHESIS GENES BY WHITE-LIGHT IN EGGPLANT HYPOCOTYL TISSUES, AND IDENTIFICATION OF AN INDUCIBLE P-450 CDNA	37	12
2317	5	8845 1993 THERAPEUTIC DRUG MONITORING 15(1):18-24 GRAM LF; HANSEN MGJ; SINDRUP SH; BROSEN K; POULSEN JH; AAESJORGENSEN T; OVERO KF CITALOPRAM - INTERACTION STUDIES WITH LEVOMEPROMAZINE, IMIPRAMINE, AND LITHIUM	65	12
2318	13	8943 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 201(2):973-979 WRIGHT MC; PAINE AJ INDUCTION OF THE CYTOCHROME-P450-3A SUBFAMILY IN RAT-LIVER CORRELATES WITH THE BINDING OF INDUCERS TO A MICROSOMAL PROTEIN	21	12
2319	15	8976 1994 BIOCHEMICAL PHARMACOLOGY 48(6):1095-1103 BOTTO F; SEREE E; ELKHYARI S; DESOUSA G; MASSACRIER A; PLACIDI M; CAU P; PELLET W; RAHMANI R; BARRA Y TISSUE-SPECIFIC EXPRESSION AND METHYLATION OF THE HUMAN CYP2E1 GENE	21	12
2320	6	9114 1994 EUROPEAN JOURNAL OF BIOCHEMISTRY 224(2):335-343 AKIYOSHISHIBATA M; SAKAKI T; OHYAMA Y; NOSHIRO M; OKUDA K; YABUSAKI Y FURTHER OXIDATION OF HYDROXYCALCIDIOL BY CALCIDIOL 24- HYDROXYLASE - A STUDY WITH THE MATURE ENZYME EXPRESSED IN ESCHERICHIA-COLI	60	12
2321	10	9115 1994 EUROPEAN JOURNAL OF BIOCHEMISTRY 224(3):835-844 PIERREL MA; BATARD Y; KAZMAIER M; MIGNOTTEVIEUX C; DURST F; WERCKREICHHART D CATALYTIC PROPERTIES OF THE PLANT CYTOCHROME-P450 CYP73 EXPRESSED IN YEAST - SUBSTRATE-SPECIFICITY OF A CINNAMATE HYDROXYLASE	49	12
2322	7	9199 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(29):18716-18719 KAGAWA N; OGO A; TAKAHASHI Y; IWAMATSU A; WATERMAN MR A CAMP-REGULATORY SEQUENCE (CRS1) OF CYP17 IS A CELLULAR TARGET FOR THE HOMEODOMAIN PROTEIN PBX1	47	12
2323	3	9220 1994 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 79(1):106-112 MCALLISTER JM; BYRD W; SIMPSON ER THE EFFECTS OF GROWTH-FACTORS AND PHORBOL ESTERS ON STEROID- BIOSYNTHESIS IN ISOLATED HUMAN THECA INTERNA AND GRANULOSA- LUTEIN CELLS IN LONG-TERM CULTURE	35	12
2324	17	9236 1994 JOURNAL OF NEUROCHEMISTRY 63(2):671-676 STROMSTEDT M; WARNER M; GUSTAFSSON JA CYTOCHROME P450S OF THE 4A SUBFAMILY IN THE BRAIN	25	12
2325	20	9254 1994 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 271(1):557-566 THUMMEL KE; SHEN DD; PODOLL TD; KUNZE KL; TRAGER WF; BACCHI CE; MARSH CL; MCVICAR JP; BARR DM; PERKINS JD; CARITHERS RL USE OF MIDAZOLAM AS A HUMAN CYTOCHROME-P450-3A PROBE .2. CHARACTERIZATION OF INTERINDIVIDUAL AND INTRAINDIVIDUAL HEPATIC CYP3A VARIABILITY AFTER LIVER-TRANSPLANTATION	98	12
2326	10	9345 1994 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91(3):1019-1023 WARNER M; GUSTAFSSON JA EFFECT OF ETHANOL ON CYTOCHROME-P450 IN THE RAT-BRAIN	56	12
2327	8	9346 1994 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91(15):7002-7006 PALLER MS; JACOB HS CYTOCHROME-P-450 MEDIATES TISSUE-DAMAGING HYDROXYL RADICAL FORMATION DURING REOXYGENATION OF THE KIDNEY	56	12
2328	6	9352 1994 PSYCHOPHARMACOLOGY BULLETIN 30(2):251-259 PRESKORN SH; MAGNUS RD INHIBITION OF HEPATIC P-450 ISOENZYMES BY SEROTONIN SELECTIVE REUPTAKE INHIBITORS - IN-VITRO AND IN-VIVO FINDINGS AND THEIR IMPLICATIONS FOR PATIENT-CARE	54	12
2329	14	9416 1995 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 35():483-507 LAKE BG MECHANISMS OF HEPATOCARCINOGENICITY OF PEROXISOME-PROLIFERATING DRUGS AND CHEMICALS	98	12
2330	19	9424 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 316(1):443-451 ZELDIN DC; WEI SZ; FALCK JR; HAMMOCK BD; SNAPPER JR; CAPDEVILA JH METABOLISM OF EPOXYEICOSATRIENOIC ACIDS BY CYTOSOLIC EPOXIDE HYDROLASE - SUBSTRATE STRUCTURAL DETERMINANTS OF ASYMMETRIC CATALYSIS	29	12
2331	8	9430 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 317(1):299-304 WANG MH; WADE D; CHEN LS; WHITE S; YANG CS PROBING THE ACTIVE-SITES OF RAT AND HUMAN CYTOCHROME-P450 2E1 WITH ALCOHOLS AND CARBOXYLIC-ACIDS	29	12
2332	22	9442 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 319(2):372-382 SAKAMOTO K; KIRITA S; BABA T; NAKAMURA Y; YAMAZOE Y; KATO R; TAKANAKA A; MATSUBARA T A NEW CYTOCHROME-P450 FORM BELONGING TO THE CYP2D IN DOG LIVER- MICROSOMES - PURIFICATION, CDNA CLONING, AND ENZYME CHARACTERIZATION	25	12
2333	19	9445 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 320(2):289-296 ALTERMAN MA; CHAURASIA CS; LU P; HARDWICK JP; HANZLIK RP FATTY-ACID DISCRIMINATION AND OMEGA-HYDROXYLATION BY CYTOCHROME-P450 4A1 AND A CYTOCHROME P4504A1/NADPH-P450 REDUCTASE FUSION PROTEIN	24	12
2334	22	9453 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 322(1):189-197 PIKULEVA IA; MACKMAN RL; KAGAWA N; WATERMAN MR; DEMONTELLANO PRO ACTIVE-SITE TOPOLOGY OF BOVINE CHOLESTEROL SIDE-CHAIN CLEAVAGE CYTOCHROME-P450 (P450SCC) AND EVIDENCE FOR INTERACTION OF TYROSINE-94 WITH THE SIDE-CHAIN OF CHOLESTEROL	16	12
2335	26	9488 1995 BIOCHEMICAL PHARMACOLOGY 49(5):591-602 BENSOUSSAN C; DELAFORGE M; MANSUY D PARTICULAR ABILITY OF CYTOCHROMES P450 3A TO FORM INHIBITORY P450-IRON-METABOLITE COMPLEXES UPON METABOLIC OXIDATION OF AMINODRUGS	38	12
2336	24	9535 1995 BIOCHIMIE 77(7-8):604-620 VERGERES G; WASKELL L CYTOCHROME B(5), ITS FUNCTIONS, STRUCTURE AND MEMBRANE TOPOLOGY	37	12
2337	25	9624 1995 DRUG METABOLISM AND DISPOSITION 23(11):1231-1241 SHARER JE; SHIPLEY LA; VANDENBRANDEN MR; BINKLEY SN; WRIGHTON SA COMPARISONS OF PHASE-I AND PHASE-II IN-VITRO HEPATIC ENZYME- ACTIVITIES OF HUMAN, DOG, RHESUS-MONKEY, AND CYNOMOLGUS MONKEY	54	12
2338	11	9671 1995 FEBS LETTERS 374(2):270-272 MCKAY JA; MELVIN WT; AHSEE AK; EWEN SWB; GREENLEE WF; MARCUS CB; BURKE MD; MURRAY GI EXPRESSION OF CYTOCHROME-P450 CYP1B1 IN BREAST-CANCER	39	12
2339	11	9723 1995 JOURNAL OF BIOLOGICAL CHEMISTRY 270(22):13561-13566 MICHAEL MD; KILGORE MW; MOROHASHI K; SIMPSON ER AD4BP/SF-1 REGULATES CYCLIC AMP-INDUCED TRANSCRIPTION FROM THE PROXIMAL PROMOTER (PII) OF THE HUMAN AROMATASE P450 (CYP19) GENE IN THE OVARY	87	12
2340	4	9871 1995 PROTEINS-STRUCTURE FUNCTION AND GENETICS 21(3):237-243 PAULSEN MD; ORNSTEIN RL DRAMATIC DIFFERENCES IN THE MOTIONS OF THE MOUTH OF OPEN AND CLOSED CYTOCHROME P450BM-3 BY MOLECULAR-DYNAMICS SIMULATIONS	42	12
2341	16	9954 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 328(1):143-150 Paine MJI; Gilham D; Roberts GCK; Wolf CR Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems	25	12
2342	24	9956 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 328(2):245-254 Scheller U; Zimmer T; Kargel E; Schunck WH Characterization of the n-alkane and fatty acid hydroxylating cytochrome P450 forms 52A3 and 52A4	17	12
2343	13	9959 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 329(1):31-38 James MO; Boyle SM; TrapidoRosenthal HG; Smith WC; Greenberg RM; Shiverick KT cDNA and protein sequence of a major form of P450, CYP2L, in the hepatopancreas of the spiny lobster, Panulirus argus	14	12
2344	14	10007 1996 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 225(2):689-694 Greuet J; Pichard L; Bonfils C; Domergue J; Maurel P The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture	25	12
2345	13	10088 1996 CANCER RESEARCH 56(6):1296-1302 Marre F; Sanderink GJ; deSousa G; Gaillard C; Martinet M; Rahmani R Hepatic biotransformation of docetaxel (Taxotere(R)) in vitro: Involvement of the CYP3A subfamily in humans	67	12
2346	12	10118 1996 CLINICAL PHARMACOLOGY & THERAPEUTICS 59(6):613-623 Engel G; Hofmann U; Heidemann H; Cosme J; Eichelbaum M Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4- hydroxyantipyrine, 3-hydromethylantipyrine, and norantipyrine formation	79	12
2347	9	10146 1996 DRUG METABOLISM AND DISPOSITION 24(3):322-328 Zhang QY; Wikoff J; Dunbar D; Kaminsky L Characterization of rat small intestinal cytochrome P450 composition and inducibility	45	12
2348	19	10210 1996 GENOMICS 38(3):371-381 Rozman D; Stromstedt M; Tsui LC; Scherer SW; Waterman MR Structure and mapping of the human lanosterol 14 alpha- demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; Comparison of exon/intron organization with other mammalian and fungal CYP genes	33	12
2349	13	10231 1996 JOURNAL OF BIOCHEMISTRY 119(3):435-440 Nakayama N; Takemae A; Shoun H Cytochrome P450foxy, a catalytically self-sufficient fatty acid hydroxylase of the fungus Fusarium oxysporum	15	12
2350	19	10242 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(24):14001-14009 VanRollins M; Kaduce TL; Fang X; Knapp HR; Spector AA Arachidonic acid diols produced by cytochrome P-450 monooxygenases are incorporated into phospholipids of vascular endothelial cells	29	12
2351	9	10254 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(45):28176-28180 Kawashima H; Sequeira DJ; Nelson DR; Strobel HW Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18 catalyzing imipramine N-demethylation	29	12
2352	35	10288 1996 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 16(4):273-285 Harvey AT; Preskorn SH Cytochrome p450 enzymes: Interpretation of their interactions with selective serotonin reuptake inhibitors .1.	57	12
2353	5	10363 1996 NATURE STRUCTURAL BIOLOGY 3(7):632-637 CuppVickery JR; Han O; Hutchinson CR; Poulos TL Substrate-assisted catalysis in cytochrome P450eryF	34	12
2354	16	10389 1996 PLANT PHYSIOLOGY 110(3):1035-1046 Frank MR; Deyneka JM; Schuler MA Cloning of wound-induced cytochrome P450 monooxygenases expressed in pea	31	12
2355	24	10465 1997 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 16(3):242-249 Anttila S; Hukkanen J; Hakkola J; Stjernvall T; Beaune P; Edwards RJ; Boobis AR; Pelkonen O; Raunio H Expression and localization of CYP3A4 and CYP3A5 in human lung	35	12
2356	27	10526 1997 ARCHIVES OF TOXICOLOGY 71(6):401-408 Shimada T; Mimura M; Inoue K; Nakamura S; Oda H; Ohmori S; Yamazaki H Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans	42	12
2357	9	10611 1997 CHEMICAL RESEARCH IN TOXICOLOGY 10(1):41-48 deGroot MJ; Bijloo GJ; Martens BJ; vanAcker FAA; Vermeulen NPE A refilled substrate model for human cytochrome P450 2D6	30	12
2358	18	10649 1997 DRUG METABOLISM AND DISPOSITION 25(2):168-174 Yamazaki H; Inoue K; Turvy CG; Guengerich FP; Shimada T Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome p450 enzymes	29	12
2359	9	10734 1997 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 27(6):605-615 Rose RL; Goh D; Thompson DM; Verma KD; Heckel DG; Gahan LJ; Roe RM; Hodgson E Cytochrome P450 (CYP)9A1 in Heliothis virescens: The first member of a new CYP family	22	12
2360	5	10758 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(38):23995-24001 Schwarz M; Lund EG; Lathe R; Bjorkhem I; Russell DW Identification and characterization of a mouse oxysterol 7 alpha-hydroxylase cDNA	75	12
2361	25	10816 1997 LIFE SCIENCES 61(26):2507-2520 Szklarz GD; Halpert JR Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450	28	12
2362	6	10897 1997 SCIENCE 277(5333):1827-1830 Takeyama K; Kitanaka S; Sato T; Kobori M; Yanagisawa J; Kato S 25-hydroxyvitamin D-3 1 alpha-hydroxylase and vitamin D synthesis	136	12
2363	28	11043 1998 BIOCHEMISTRY 37(17):6106-6113 Jenkins CM; Waterman MR NADPH-Flavodoxin reductase and flavodoxin from Escherichia coli: Characteristics as a soluble microsomal P450 reductase	23	12
2364	22	11109 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(6):659-665 Yamazaki H; Shaw PM; Guengerich FP; Shimada T Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes	36	12
2365	26	11110 1998 CHEMICAL RESEARCH IN TOXICOLOGY 11(9):1048-1056 Shimada T; Yamazaki H; Foroozesh M; Hopkins NE; Alworth WL; Guengerich FP Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1	47	12
2366	2	11133 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):15-22 Nelson DR Metazoan cytochrome P450 evolution	24	12
2367	51	11138 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):107-137 Buhler DR; Wang-Buhler JL Rainbow trout cytochrome P450s: purification, molecular aspects, metabolic activity, induction and role in environmental monitoring	40	12
2368	19	11142 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):231-240 Morrison HG; Weil EJ; Karchner SI; Sogin ML; Stegeman JJ Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1 genes: update with new sequences	21	12
2369	17	11262 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(26):16155-16162 Huss JM; Kasper CB Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression	29	12
2370	12	11400 1998 STRUCTURE WITH FOLDING & DESIGN 6(9):1079-1085 Peterson JA; Graham SE A close family resemblance: the importance of structure in understanding cytochromes P450	28	12
2371	37	11510 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266(3):690-698 Omura T Forty years of cytochrome P450	29	12
2372	49	12363 2001 BIOCHEMISTRY 40(16):5018-5031 Guryev OL; Gilep AA; Usanov SA; Estabrook RW Interaction of apo-cytochrome b(5) with cytochromes P4503A4 and P45017A: Relevance of heme transfer reactions	12	12
2373	85	12409 2001 CHEMICAL RESEARCH IN TOXICOLOGY 14(6):611-650 Guengerich FP Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity	47	12
2374	6	12582 2001 MOLECULAR PHARMACOLOGY 60(3):427-431 Goodwin B; Moore LB; Stoltz CM; McKee DD; Kliewer SA Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor	47	12
2375	2	75 1959 SCIENCE 129(3341):98-99 AMBE KS; CRANE FL PHOSPHOLIPASE-INDUCED RELEASE OF CYTOCHROME-C FROM THE ELECTRON TRANSPORT PARTICLE	53	11
2376	4	127 1961 BIOCHIMICA ET BIOPHYSICA ACTA 52(1):119-& HATEFI Y; HAAVIK AG; JURTSHUK P STUDIES ON ELECTRON TRANSPORT SYSTEM .31. DPNH-CYTOCHROME C REDUCTASE 2	34	11
2377	3	199 1963 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 10(1):23-& ERNSTER L; AZZONE GF; DALLNER G COMPARISON OF EFFECTS OF ROTENONE AND AMYTAL ON MITOCHONDRIAL ELECTRON AND ENERGY TRANSFER AND TITRATION OF RESPIRATORY CHAIN WITH ROTENONE	23	11
2378	4	279 1964 BERICHTE DER BUNSEN-GESELLSCHAFT FUR PHYSIKALISCHE CHEMIE 68(8-9):768-& HESS B; CHANCE B; BETZ A ISOLIERUNG EINES OSZILLIERENDEN SYSTEMS AUS S. CARLSBERGENSIS	18	11
2379	3	307 1964 BIOCHIMICA ET BIOPHYSICA ACTA 92(3):446-& VALLIN I; LOW H SUCCINATE-LINKED NICOTINAMIDE-ADENINE DINUCLEOTIDE REDUCTION COUPLED WITH AEROBIC OXIDATION OF REDUCED TETRAMETHYL-P- PHENYLENEDIAMINE IN SUBMITOCHONDRIAL PARTICLES	23	11
2380	5	318 1964 JOURNAL OF BIOLOGICAL CHEMISTRY 239(6):1989-& KING TE; NICKEL KS; JENSEN DR IRON COPPER CYTOCHROME + LIPID CONTENTS OF HEART MUSCLE PREPARATION + HEART MITOCHONDRIA	73	11
2381	4	424 1965 JOURNAL OF BIOLOGICAL CHEMISTRY 240(9):3645-& CREMONA T; KEARNEY EB STUDIES ON RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE .X. REACTIONS WITH SULFHYDRYL REAGENTS	23	11
2382	1	438 1965 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 53(5):1076-& PRESSMAN BC INDUCED ACTIVE TRANSPORT OF IONS IN MITOCHONDRIA	365	11
2383	4	529 1966 JOURNAL OF BIOCHEMISTRY 60(6):660-& HORIE S; KINOSHIT.T; SHIMAZON.N STUDIES ON P-450 .2. ON ABSORPTION SPECTRUM OF P-450 IN MITOCHONDRIAL FRAGMENTS FROM BOVINE ADRENAL CORTEX	14	11
2384	2	642 1967 BIOCHIMICA ET BIOPHYSICA ACTA 131(3):421-& WILSON DF; CHANCE B AZIDE INHIBITION OF MITOCHONDRIAL ELECTRON TRANSPORT .I. AEROBIC STEADY STATE OF SUCCINATE OXIDATION	74	11
2385	1	820 1968 BIOCHIMICA ET BIOPHYSICA ACTA 170(2):366-& CHEN C; LIN CC MECHANISM OF ALIPHATIC HYDROXYLATION - TETRALIN HYDROPEROXIDE AS AN INTERMEDIATE IN HYDROXYLATION OF TETRALIN IN RAT-LIVER HOMOGENATE	26	11
2386	6	861 1968 JAPANESE JOURNAL OF PHARMACOLOGY 18(2):224-& KATO R; TAKANAKA A; TAKAHASH.A; ONODA K DRUG METABOLISM IN TUMOR-BEARING RATS .I. ACTIVITIES OF NADPH- LINKED ELECTRON TRANSPORT AND DRUG-METABOLIZING ENZYME SYSTEMS IN LIVER MICROSOMES OF TUMOR-BEARING RATS	90	11
2387	6	994 1969 BIOCHEMICAL JOURNAL 111(5):665-& TYLER DD EVIDENCE OF A PHOSPHATE-TRANSPORTER SYSTEM IN INNER MEMBRANE OF ISOLATED MITOCHONDRIA	215	11
2388	5	1008 1969 BIOCHEMICAL PHARMACOLOGY 18(8):1991-& TERRIERE LC; CHAN TM ENHANCEMENT OF RAT LIVER MICROSOMAL OXIDASES BY MAGNESIUM AND A HEAT-STABLE FACTOR FROM SOLUBLE FRACTION	24	11
2389	4	1079 1969 FEBS LETTERS 3(1):5-& BETZ A; SELKOV E CONTROL OF PHOSPHOFRUCTOKINASE [PFK] ACTIVITY IN CONDITIONS SIMULATING THOSE OF GLYCOLYSING YEAST EXTRACT	20	11
2390	9	1091 1969 JAPANESE JOURNAL OF PHARMACOLOGY 19(1):25-& KATO R; TAKANAKA.A; OSHIMA T EFFECT OF VITAMIN C DEFICIENCY ON METABOLISM OF DRUGS AND NADPH-LINKED ELECTRON TRANSPORT SYSTEM IN LIVER MICROSOMES	56	11
2391	6	1132 1969 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 168(2):224-& GUARINO AM; GRAM TE; SCHROEDE.DH; CALL JB; GILLETTE JR ALTERATIONS IN KINETIC CONSTANTS FOR HEPATIC MICROSOMAL ANILINE HYDROXYLASE AND ETHYLMORPHINE N-DEMETHYLASE ASSOCIATED WITH PREGNANCY IN RATS	63	11
2392	35	1157 1969 PHYSIOLOGICAL REVIEWS 49(1):48-& LEMBERG MR CYTOCHROME OXIDASE	229	11
2393	5	1205 1970 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 141(1):18-& BROWNIE AC; SIMPSON ER; SKELTON FR; ELLIOTT WB; ESTABROOK RW INTERACTION OF ANDROGENS WITH ADRENAL MITOCHONDRIAL CYTOCHROME SYSTEM - INFLUENCE OF ANDROGEN TREATMENT ON LEVELS OF CYTOCHROME IN RAT ADRENAL CORTICAL MITOCHONDRIA AND ON SUBSTRATE-INDUCED SPECTRAL CHANGES	11	11
2394	9	1284 1970 CANCER RESEARCH 30(7):2061-& SATO N; HAGIHARA B SPECTROPHOTOMETRIC ANALYSES OF CYTOCHROMES IN ASCITES HEPATOMAS OF RATS AND MICE	55	11
2395	2	1291 1970 ENDOCRINOLOGY 86(5):1085-& BROWNIE AC; COLBY HD; GALLANT S; SKELTON FR SOME STUDIES ON EFFECT OF ANDROGENS ON ADRENAL CORTICAL FUNCTION OF RATS	28	11
2396	6	1326 1970 JAPANESE JOURNAL OF PHARMACOLOGY 20(4):546-& KATO R; ONODA KI; TAKANAKA A SPECIES DIFFERENCE IN DRUG METABOLISM BY LIVER MICROSOMES IN ALLOXAN DIABETIC OR FASTED ANIMALS .1. ACTIVITY OF DRUG- METABOLIZING ENZYMES AND ELECTRON TRANSPORT SYSTEM	64	11
2397	13	1339 1970 JOURNAL OF BIOCHEMISTRY 68(5):613-& KATO R; TAKANAKA A; TAKAHASH.A EFFECT OF THYROID HORMONE ON SUBSTRATE INTERACTION WITH P-450 IN OXIDATION OF DRUGS BY LIVER MICROSOMES	41	11
2398	13	1345 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(8):1992-& GUTMAN M; SINGER TP; CASIDA JE STUDIES ON RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE .17. REACTION SITES OF PIERICIDIN A AND ROTENONE	89	11
2399	6	1360 1970 JOURNAL OF CELL BIOLOGY 45(3):640-& ICHIKAWA Y; KURODA M; YAMANO T ZONATION OF HEMOPROTEIN P-450 AND CYTOCHROME B5 IN ADRENOCORTEX OF MAMMALS	26	11
2400	13	1370 1970 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 174(2):211-& KATO R; TAKASHI A; OHSHIMA T; HOSOYA E EFFECT OF MORPHINE ADMINISTRATION ON HYDROXLYLATION OF STEROID HORMONES BY RAT LIVER MICROSOMES	31	11

#	Cited nodes	Nodes / Authors	GCS	LCS
2401	11	1429 1971 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 179(JUL6):561-& NEBERT DW; BAUSSERM.LL ARYL HYDROCARBON HYDROXYLASE INDUCTION IN CELL CULTURE AS A FUNCTION OF GENE EXPRESSION	40	11
2402	5	1463 1971 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42(1):1-& RUBIN E; GANG H; LIEBER CS INTERACTION OF ETHANOL AND PYRAZOLE WITH HEPATIC MICROSOMES	53	11
2403	6	1518 1971 BIOCHEMISTRY 10(8):1496-& YOUNG DG; HALL PF STEROID HYDROXYLATION IN BOVINE ADRENOCORTICAL MITOCHONDRIA - COMPETITION BETWEEN SIDE-CHAIN CLEAVAGE OF CHOLESTEROL AND 11BETA HYDROXYLATION	19	11
2404	7	1520 1971 BIOCHEMISTRY 10(15):2909-& MCINTOSH EN; UZGIRIS VI; ALONSO C; SALHANIC.HA SPECTRAL PROPERTIES, RESPIRATORY ACTIVITY, AND ENZYME SYSTEMS OF BOVINE CORPUS LUTEUM MITOCHONDRIA	33	11
2405	1	1538 1971 BIOCHIMICA ET BIOPHYSICA ACTA 250(1):14-& ISOHASHI F; SHIBAYAM.K; MARUYAMA E; AOKI Y; WADA F IMMUNOCHEMICAL STUDIES ON MALATE DEHYDROGENASE (DECARBOXYLATING) (NADP)	28	11
2406	8	1821 1972 BIOCHIMICA ET BIOPHYSICA ACTA 263(1):41-& REICHMAN LM; ROZANTZE.EG; ANNAEV B STUDIES OF MICROSOMAL CYTOCHROME-P-450 WITH ISOCYANIDE SPIN LABEL	23	11
2407	12	1824 1972 BIOCHIMICA ET BIOPHYSICA ACTA 267(1):15-& DUTTON PL; PRING M; SATO N; WILSON DF; MUKAI Y; ERECINSK.M REACTIONS OF B-CYTOCHROMES WITH ATP AND ANTIMYCIN A IN PIGEON HEART-MITOCHONDRIA	68	11
2408	8	1838 1972 BIOCHIMICA ET BIOPHYSICA ACTA 275(3):288-& SATO N; OHNISHI T; CHANCE B SPECTRAL STUDY OF B CYTOCHROMES IN YEAST MITOCHONDRIA AND INTACT CELLS	42	11
2409	6	2040 1973 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 212(JUN22):76-88 MASTERS BSS; TAYLOR WE; ISAACSON EL; BARON J; HARKINS JB; NELSON EB; BRYAN GT STUDIES ON FUNCTION OF ADRENODOXIN AND TPNH-CYTOCHROME C REDUCTASE IN MITOCHONDRIA AND MICROSOMES OF ADRENAL-CORTEX, UTILIZING IMMUNOCHEMICAL TECHNIQUES	15	11
2410	7	2048 1973 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 212(JUN22):307-318 JOHNSON LR; RUHMANNW.A; NELSON DH IN-VIVO EFFECT OF ACTH ON UTILIZATION OF REDUCING ENERGY FOR PREGNENOLONE SYNTHESIS BY ADRENAL MITOCHONDRIA	44	11
2411	5	2072 1973 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 159(1):32-38 PURVIS JL; CANICK JA; ROSENBAU.JH; HOLOGGIT.J; LATIF SA CONTROL OF CYTOCHROME-P-450 IN RAT TESTIS MITOCHONDRIA BY HUMAN CHORIONIC GONADOTROPIN	36	11
2412	13	2095 1973 BIOCHEMICAL PHARMACOLOGY 22(3):293-310 HAMRICK ME; ZAMPAGLI.NG; STRIPP B; GILLETTE JR INVESTIGATION OF EFFECTS OF METHYLTESTOSTERONE, CORTISONE AND SPIRONOLACTONE ON HEPATIC MICROSOMAL MIXED-FUNCTION OXIDASE SYSTEM IN MALE AND FEMALE RATS	47	11
2413	15	2098 1973 BIOCHEMICAL PHARMACOLOGY 22(8):905-910 MULLER D; FORSTER D; DIETZE H; LANGENBE.R; KLINGER W INFLUENCE OF AGE AND BARBITAL TREATMENT ON CONTENT OF CYTOCHROME-P-450 AND B5 AND ON ACTIVITY OF GLUCOSE-6- PHOSPHATASE IN MICROSOMES OF RAT-LIVER AND KIDNEY	28	11
2414	24	2133 1973 BIOCHIMICA ET BIOPHYSICA ACTA 301(2):105-128 OHNISHI T MECHANISM OF ELECTRON-TRANSPORT AND ENERGY CONSERVATION IN SITE-I REGION OF RESPIRATORY-CHAIN	120	11
2415	12	2190 1973 DRUG METABOLISM AND DISPOSITION 1(1):45-61 PEISACH J; STERN JO; BLUMBERG WE OPTICAL AND MAGNETIC PROBES OF STRUCTURE OF CYTOCHROME P-450S	41	11
2416	8	2229 1973 EUROPEAN JOURNAL OF BIOCHEMISTRY 37(2):334-340 BOYD GS; GRIMWADE AM; LAWSON ME STUDIES ON RAT-LIVER MICROSOMAL CHOLESTEROL 7 ALPHA-HYDROXYLASE	74	11
2417	3	2346 1973 PREPARATIVE BIOCHEMISTRY 3(5):495-508 NEARY JT; DAVIDSON B; ARMSTRON.A; MALOOF F PARTIAL-PURIFICATION AND SOME PROPERTIES OF THYROID-PEROXIDASE SOLUBILIZED BY ALKALINE TREATMENT	18	11
2418	4	2415 1974 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 59(1):334-339 VONBAHR C; VADI H; GRUNDIN R; MOLDEUS P; ORRENIUS S SPECTRAL STUDIES ON RAPID UPTAKE AND SUBSEQUENT BINDING OF DRUGS TO CYTOCHROME-P-450 IN ISOLATED RAT-LIVER CELLS	25	11
2419	12	2586 1974 LIFE SCIENCES 15(4):657-670 KUPFER D INTERACTIONS OF PROSTAGLANDINS WITH HEPATIC MICROSOMAL CYTOCHROME-P-450	29	11
2420	7	2674 1975 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 170(1):124-131 BURK RF; SILERMASTERS BS SOME EFFECTS OF SELENIUM DEFICIENCY ON HEPATIC MICROSOMAL CYTOCHROME-P-450 SYSTEM IN RAT	65	11
2421	7	2720 1975 BIOCHEMICAL SOCIETY TRANSACTIONS 3(6):807-811 HILDEBRANDT AG; TJOE M; ROOTS I MONOOXYGENASE-LINKED HYDROGEN-PEROXIDE PRODUCTION AND DEGRADATION IN LIVER MICROSOMAL FRACTIONS	18	11
2422	3	2728 1975 BIOCHEMICAL SOCIETY TRANSACTIONS 3(6):970-972 DICKINS M; ELCOMBE CR; NIMMOSMITH RH; BRIDGES JW STRUCTURE-BINDING RELATIONSHIPS BETWEEN BENZIMIDAZOLES AND CYTOCHROME-P-450	17	11
2423	20	2803 1975 EUROPEAN JOURNAL OF BIOCHEMISTRY 60(2):615-620 NASTAINZCYK W; RUF HH; ULLRICH V LIGAND-BINDING OF ORGANIC SULFIDES TO MICROSOMAL CYTOCHROME-P- 450	29	11
2424	16	2857 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(20):8010-8015 MITANI F; ICHIYAMA A; MASUDA A; OGATA I ENZYMIC STUDIES ON ADRENOCORTICAL DEOXYCORTICOSTERONE 11BETA- HYDROXYLASE SYSTEM	22	11
2425	31	2912 1975 USPEKHI KHIMII 44(5):868-896 AKHREM AA; METELITSA DI; SKURKO ME ENZYMES - MONOOXYGENASES AND THEIR MODELING METHODS	30	11
2426	7	2968 1976 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 176(1):103-112 BISSELL DM; HAMMAKER LE CYTOCHROME-P-450 HEME AND REGULATION OF DELTA-AMINOLEVULINIC- ACID SYNTHETASE IN LIVER	89	11
2427	11	2996 1976 BIOCHEMICAL PHARMACOLOGY 25(8):951-955 GREINER JW; KRAMER RE; ROBINSON DA; CANADY WJ; COLBY HD INTERACTION OF AROMATIC-HYDROCARBONS AND DRUGS WITH ADRENAL MICROSOMAL CYTOCHROME-P-450 IN GUINEA-PIG	26	11
2428	10	3022 1976 BIOCHIMICA ET BIOPHYSICA ACTA 449(1):59-71 SIMPSON ER; WILLIAMSSMITH DL ELECTRON-PARAMAGNETIC RESONANCE-SPECTRA OF MITOCHONDRIAL AND MICROSOMAL CYTOCHROME-P-450 FROM RAT ADRENAL	19	11
2429	17	3062 1976 DRUG METABOLISM AND DISPOSITION 4(2):190-194 KAWALEK JC; LEVIN W; RYAN D; LU AYH RECONSTITUTED LIVER MICROSOMAL-ENZYME SYSTEM THAT HYDROXYLATES DRUGS, OTHER FOREIGN COMPOUNDS, AND ENDOGENOUS SUBSTRATES .9. FORMATION OF A 455-NM METABOLITE-CYTOCHROME P-450 COMPLEX	13	11
2430	5	3084 1976 EUROPEAN JOURNAL OF BIOCHEMISTRY 70(1):7-13 DEME D; GAVARET JM; POMMIER J; NUNEZ J MAXIMAL NUMBER OF HORMONOGENIC IODOTYROSINE RESIDUES IN THYROGLOBULIN IODINATED BY THYROID PEROXIDASE	36	11
2431	11	3122 1976 JOURNAL OF BIOLOGICAL CHEMISTRY 251(1):79-87 OESCH F DIFFERENTIAL CONTROL OF RAT MICROSOMAL ARYL-HYDROCARBON MONOOXYGENASE AND EPOXIDE HYDRATASE	123	11
2432	16	3204 1976 TOXICOLOGY 5(3):297-309 LAKE BG; PHILLIPS JC; HEADING CE; GANGOLLI SD STUDIES ON INVITRO METABOLISM OF DIMETHYLNITROSAMINE BY RAT- LIVER	73	11
2433	4	3208 1976 TOXICOLOGY AND APPLIED PHARMACOLOGY 38(1):71-77 FABACHER DL; HODGSON E INDUCTION OF HEPATIC MIXED-FUNCTION OXIDASE ENZYMES IN ADULT AND NEONATAL MICE BY KEPONE AND MIREX	64	11
2434	23	3213 1976 XENOBIOTICA 6(6):363-375 COX PJ; KING LJ; PARKE DV BINDING OF TRICHLOROFLUOROMETHANE AND OTHER HALOALKANES TO CYTOCHROME-P-450 UNDER AEROBIC AND ANAEROBIC CONDITIONS	22	11
2435	7	3266 1977 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 78(4):1254-1262 CEDERBAUM AI; DICKER E; RUBIN E; COHEN G EFFECT OF DIMETHYLSULFOXIDE AND OTHER HYDROXYL RADICAL SCAVENGERS ON OXIDATION OF ETHANOL BY RAT-LIVER MICROSOMES	94	11
2436	4	3316 1977 CANCER RESEARCH 37(4):1075-1082 SEIDEGARD J; DEPIERRE JW; MORON MS; JOHANNESEN KAM; ERNSTER L CHARACTERIZATION OF RAT LUNG EPOXIDE (STYRENE OXIDE) HYDRASE WITH A MODIFIED RADIOACTIVE ASSAY OF IMPROVED SENSITIVITY	75	11
2437	5	3425 1977 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 99(19):6441-6443 MANSUY D; BATTIONI P; CHOTTARD JC; LANGE M NITROSOALKANES AS NEW LIGANDS OF IRON(II) PORPHYRINS AND HEMOPROTEINS	51	11
2438	5	3432 1977 LIFE SCIENCES 21(11):1629-1635 PROUGH RA; SIPAL Z; JAKOBSSON SW METABOLISM OF BENZO(A)PYRENE BY HUMAN LUNG MICROSOMAL FRACTIONS	37	11
2439	20	3433 1977 METABOLISM-CLINICAL AND EXPERIMENTAL 26(6):665-718 DEGROOT LJ; NIEPOMNISZCZE H BIOSYNTHESIS OF THYROID-HORMONE - BASIC AND CLINICAL ASPECTS	127	11
2440	16	3486 1978 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 187(1):153-157 BLUM H; LEIGH JS; SALERNO JC; OHNISHI T ORIENTATION OF BOVINE ADRENAL-CORTEX CYTOCHROME-P-450 IN SUB- MITOCHONDRIAL PARTICLE MULTILAYERS	26	11
2441	15	3592 1978 EUROPEAN JOURNAL OF BIOCHEMISTRY 86(2):573-579 MANSUY D; BEAUNE P; CRESTEIL T; BACOT C; CHOTTARD JC; GANS P FORMATION OF COMPLEXES BETWEEN MICROSOMAL CYTOCHROME P-450- FE(II) AND NITROSOARENES OBTAINED BY OXIDATION OF ARYLHYDROXYLAMINES OR REDUCTION OF NITROARENES INSITU	28	11
2442	12	3631 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(14):4874-4880 JONES DP; MASON HS GRADIENTS OF O2 CONCENTRATION IN HEPATOCYTES	155	11
2443	62	3671 1978 PHARMACOLOGY & THERAPEUTICS PART A-CHEMOTHERAPY TOXICOLOGY AND METABOLIC INHIBITORS 2(4):727-749 CINTI DL AGENTS ACTIVATING LIVER MICROSOMAL MIXED-FUNCTION OXIDASE SYSTEM	39	11
2444	5	3707 1978 XENOBIOTICA 8(2):65-71 STATHAM CN; ELCOMBE CR; SZYJKA SP; LECH JJ EFFECT OF POLYCYCLIC AROMATIC-HYDROCARBONS ON HEPATIC MICROSOMAL-ENZYMES AND DISPOSITION OF METHYLNAPHTHALENE IN RAINBOW-TROUT INVIVO	75	11
2445	15	3816 1979 CHEMICO-BIOLOGICAL INTERACTIONS 28(1):17-33 APPEL KE; RUF HH; MAHR B; SCHWARZ M; RICKART R; KUNZ W BINDING OF NITROSAMINES TO CYTOCHROME-P-450 OF LIVER-MICROSOMES	50	11
2446	10	3832 1979 DRUG METABOLISM REVIEWS 10(1):35-58 BRATTSTEN LB ECOLOGICAL SIGNIFICANCE OF MIXED-FUNCTION OXIDATIONS	98	11
2447	11	3866 1979 JOURNAL OF BIOCHEMISTRY 86(1):213-223 SUGIYAMA T; MIURA R; YAMANO T DIFFERENCES BETWEEN THE REACTIVITIES OF 2 PYRIDINE-NUCLEOTIDES IN THE RAPID REDUCTION PROCESS AND THE REOXIDATION PROCESS OF ADRENODOXIN REDUCTASE	15	11
2448	9	3871 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(2):547-552 HALL PF; WATANUKI M; HAMKALO BA ADRENOCORTICAL CYTOCHROME-P-450 SIDE-CHAIN CLEAVAGE - PREPARATION OF MEMBRANE-BOUND SIDE-CHAIN CLEAVAGE SYSTEM FROM PURIFIED COMPONENTS	31	11
2449	11	4042 1980 BIOCHEMISTRY 19(10):2260-2264 BASKIN LS; YANG CS CROSS-LINKING STUDIES OF CYTOCHROME-P-450 AND REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE-CYTOCHROME P-450 REDUCTASE	38	11
2450	12	4050 1980 BIOCHIMICA ET BIOPHYSICA ACTA 612(1):1-10 SWIERCZYNSKI J; STANKIEWICZ A; SCISLOWSKI P; ALEKSANDROWICZ Z ISOLATION AND REGULATORY PROPERTIES OF MITOCHONDRIAL MALIC ENZYME FROM RAT SKELETAL-MUSCLE	44	11
2451	16	4180 1980 KIDNEY INTERNATIONAL 18(5):636-647 ANDERS MW METABOLISM OF DRUGS BY THE KIDNEY	100	11
2452	1	4272 1981 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 101(4):1324-1330 AUGUSTO O; DEMONTELLANO PRO; QUINTANILHA A SPIN-TRAPPING OF FREE-RADICALS FORMED DURING MICROSOMAL METABOLISM OF ETHYLHYDRAZINE AND ACETYLHYDRAZINE	52	11
2453	6	4310 1981 BIOCHIMICA ET BIOPHYSICA ACTA 677(2):165-173 PARNHAM MJ; BRAGT PC; BAST A; ZIJLSTRA FJ COMPARISON OF THE EFFECTS OF INHIBITORS OF CYTOCHROME P-450- MEDIATED REACTIONS ON HUMAN-PLATELET AGGREGATION AND ARACHIDONIC-ACID METABOLISM	26	11
2454	11	4412 1981 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 219(1):147-155 MUAKKASSAH SF; YANG WCT MECHANISM OF THE INHIBITORY-ACTION OF PHENELZINE ON MICROSOMAL DRUG-METABOLISM	29	11
2455	2	4526 1982 BIOCHEMICAL JOURNAL 204(2):593-603 ALBANO E; LOTT KAK; SLATER TF; STIER A; SYMONS MCR; TOMASI A SPIN-TRAPPING STUDIES ON THE FREE-RADICAL PRODUCTS FORMED BY METABOLIC-ACTIVATION OF CARBON-TETRACHLORIDE IN RAT-LIVER MICROSOMAL FRACTIONS-ISOLATED HEPATOCYTES AND INVIVO IN THE RAT	123	11
2456	11	4564 1982 BIOCHIMICA ET BIOPHYSICA ACTA 709(2):273-283 RYAN DE; WOOD AW; THOMAS PE; WALZ FG; YUAN PM; SHIVELY JE; LEVIN W COMPARISONS OF HIGHLY PURIFIED HEPATIC-MICROSOMAL CYTOCHROMES- P-450 FROM HOLTZMAN AND LONG-EVANS RATS	34	11
2457	5	4579 1982 CANCER RESEARCH 42(7):2609-2615 CHA YN; HEINE HS COMPARATIVE EFFECTS OF DIETARY ADMINISTRATION OF 2(3)-TERT- BUTYL-4-HYDROXYANISOLE AND 3,5-DI-TERT-BUTYL-4-HYDROXYTOLUENE ON SEVERAL HEPATIC ENZYME-ACTIVITIES IN MICE AND RATS	135	11
2458	2	4599 1982 ENDOCRINOLOGY 111(4):1077-1085 MENDELSON CR; CLELAND WH; SMITH ME; SIMPSON ER REGULATION OF AROMATASE-ACTIVITY OF STROMAL CELLS DERIVED FROM HUMAN ADIPOSE-TISSUE	97	11
2459	8	4618 1982 FEBS LETTERS 150(1):219-222 ZIEGLER M; BLANCK J; RUCKPAUL K SPIN EQUILIBRIUM RELAXATION KINETICS OF CYTOCHROME-P450 LM2	14	11
2460	5	4749 1983 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 23():239-257 FRIDOVICH I SUPEROXIDE RADICAL - AN ENDOGENOUS TOXICANT	668	11
2461	7	4762 1983 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 225(2):596-609 MICO BA; POHL LR REDUCTIVE OXYGENATION OF CARBON-TETRACHLORIDE - TRICHLOROMETHYLPEROXYL RADICAL AS A POSSIBLE INTERMEDIATE IN THE CONVERSION OF CARBON-TETRACHLORIDE TO ELECTROPHILIC CHLORINE	38	11
2462	13	5028 1984 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 231(2):271-279 BOGGARAM V; SIMPSON ER; WATERMAN MR INDUCTION OF SYNTHESIS OF BOVINE ADRENOCORTICAL CYTOCHROME-P- 450SCC, CYTOCHROME-P-450-11-BETA, CYTOCHROME-P-450-C21, AND ADRENODOXIN BY PROSTAGLANDIN-E2 AND PROSTAGLANDIN-F2-ALPHA AND CHOLERA-TOXIN	24	11
2463	2	5234 1984 TETRAHEDRON LETTERS 25(14):1457-1458 FALCK JR; SIDDHANTA AK; ESTABROOK RW; CAPDEVILA J; MIOSKOWSKI C 5-HETE AND 8-HETE PRODUCTION BY RAT HEPATIC-MICROSOMAL CYTOCHROME-P-450	11	11
2464	14	5255 1984 XENOBIOTICA 14(10):803-814 MOLONEY SJ; SNIDER BJ; PROUGH RA THE INTERACTIONS OF HYDRAZINE DERIVATIVES WITH RAT-HEPATIC CYTOCHROME-P-450	20	11
2465	11	5290 1985 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 128(2):650-656 DEE A; CARLSON G; SMITH C; MASTERS BS; WATERMAN MR REGULATION OF SYNTHESIS AND ACTIVITY OF BOVINE ADRENOCORTICAL NADPH-CYTOCHROME-P-450 REDUCTASE BY ACTH	19	11
2466	14	5304 1985 BIOCHEMICAL PHARMACOLOGY 34(11):1907-1912 CANOVADAVIS E; CHIANG JYL; WASKELL L OBLIGATORY ROLE OF CYTOCHROME-B5 IN THE MICROSOMAL METABOLISM OF METHOXYFLURANE	22	11
2467	12	5421 1985 JOURNAL OF BIOCHEMISTRY 98(1):257-260 NONAKA Y; AIBARA S; SUGIYAMA T; YAMANO T; MORITA Y A CRYSTALLOGRAPHIC INVESTIGATION ON NADPH-ADRENODOXIN OXIDOREDUCTASE	25	11
2468	13	5508 1985 XENOBIOTICA 15(4):351-362 MARCUS CB; MURRAY M; WILKINSON CF SPECTRAL AND INHIBITORY INTERACTIONS OF METHYLENEDIOXYPHENYL AND RELATED-COMPOUNDS WITH PURIFIED ISOZYMES OF CYTOCHROME-P- 450	24	11
2469	20	5648 1986 EUROPEAN JOURNAL OF BIOCHEMISTRY 157(1):27-31 HANUKOGLU I; HANUKOGLU Z STOICHIOMETRY OF MITOCHONDRIAL CYTOCHROMES-P-450, ADRENODOXIN AND ADRENODOXIN REDUCTASE IN ADRENAL-CORTEX AND CORPUS-LUTEUM - IMPLICATIONS FOR MEMBRANE ORGANIZATION AND GENE-REGULATION	52	11
2470	3	5727 1986 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 53(2):147-157 FORKERT PG; VESSEY ML; ELCE JS; PARK SS; GELBOIN HV; COLE SPC LOCALIZATION OF PHENOBARBITAL-INDUCIBLE AND 3- METHYLCHOLANTHRENE-INDUCIBLE CYTOCHROMES P-450 IN MOUSE LUNG WITH MONOCLONAL-ANTIBODIES	33	11
2471	14	5796 1987 BIOCHEMICAL PHARMACOLOGY 36(17):2783-2787 RITTER JK; FRANKLIN MR HIGH MAGNITUDE HEPATIC CYTOCHROME-P-450 INDUCTION BY AN N- SUBSTITUTED IMIDAZOLE ANTIMYCOTIC, CLOTRIMAZOLE	32	11
2472	18	5816 1987 BIOCHEMISTRY 26(22):7084-7090 TANIGUCHI H; IMAI Y; SATO R PROTEIN-PROTEIN AND LIPID-PROTEIN INTERACTIONS IN A RECONSTITUTED CYTOCHROME-P-450 DEPENDENT MICROSOMAL MONOOXYGENASE	22	11
2473	2	5842 1987 CANCER RESEARCH 47(16):4271-4277 KENSLER TW; EGNER PA; DOLAN PM; GROOPMAN JD; ROEBUCK BD MECHANISM OF PROTECTION AGAINST AFLATOXIN TUMORIGENICITY IN RATS FED 5-(2-PYRAZINYL)-4-METHYL-1,2-DITHIOL-3-THIONE (OLTIPRAZ) AND RELATED 1,2-DITHIOL-3-THIONES AND 1,2-DITHIOL-3- ONES	184	11
2474	6	5849 1987 CARCINOGENESIS 8(12):1913-1918 DEGAWA M; HISHINUMA T; YOSHIDA H; HASHIMOTO Y SPECIES, SEX AND ORGAN DIFFERENCES IN INDUCTION OF A CYTOCHROME-P-450 ISOZYME RESPONSIBLE FOR CARCINOGEN ACTIVATION - EFFECTS OF DIETARY HEPATOCARCINOGENIC TRYPTOPHAN PYROLYSATE COMPONENTS IN MICE AND RATS	45	11
2475	2	5864 1987 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 87(1):95-102 SILVA MH; HAMMOCK BD AFFINITY PURIFICATION OF CYTOSOLIC EPOXIDE HYDROLASE FROM HUMAN, RHESUS-MONKEY, BABOON, RABBIT, RAT AND MOUSE-LIVER	22	11
2476	6	5909 1987 JOURNAL OF BIOCHEMISTRY 101(6):1437-1445 DEGAWA M; YAMADA H; HISHINUMA T; MASUKO T; HASHIMOTO Y ORGAN SELECTIVE INDUCTION OF CYTOCHROME P-448 ISOZYMES IN THE RAT BY 2-METHOXY-4-AMINOAZOBENZENE AND 3-METHYLCHOLANTHRENE	25	11
2477	7	5919 1987 JOURNAL OF BIOLOGICAL CHEMISTRY 262(31):14954-14960 ATOR MA; DAVID SK; DEMONTELLANO PRO STRUCTURE AND CATALYTIC MECHANISM OF HORSERADISH-PEROXIDASE - REGIOSPECIFIC MESO-ALKYLATION OF THE PROSTHETIC HEME GROUP BY ALKYLHYDRAZINES	94	11
2478	12	6008 1988 AMBIO 17(6):376-380 HAUX C; FORLIN L BIOCHEMICAL METHODS FOR DETECTING EFFECTS OF CONTAMINANTS ON FISH	59	11
2479	5	6011 1988 AMERICAN JOURNAL OF PHYSIOLOGY 254(1):C8-C19 REVTYAK GE; JOHNSON AR; CAMPBELL WB CULTURED BOVINE CORONARY ARTERIAL ENDOTHELIAL-CELLS SYNTHESIZE HETES AND PROSTACYCLIN	52	11
2480	2	6036 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 264(2):462-471 HALPERT J; JAW JY; BALFOUR C; MASH EA; JOHNSON EF SELECTIVE INACTIVATION BY 21-CHLORINATED STEROIDS OF RABBIT LIVER AND ADRENAL MICROSOMAL CYTOCHROMES-P-450 INVOLVED IN PROGESTERONE HYDROXYLATION	12	11
2481	4	6043 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 267(1):294-304 DUIGNAN DB; SIPES IG; CIACCIO PJ; HALPERT JR THE METABOLISM OF XENOBIOTICS AND ENDOGENOUS COMPOUNDS BY THE CONSTITUTIVE DOG LIVER CYTOCHROME-P450 PBD-2	20	11
2482	3	6065 1988 BIOCHEMICAL JOURNAL 255(1):267-275 HAMILTON JW; BEMENT WJ; SINCLAIR PR; SINCLAIR JF; WETTERHAHN KE EXPRESSION OF 5-AMINOLAEVULINATE SYNTHASE AND CYTOCHROME-P-450 MESSENGER-RNAS IN CHICKEN-EMBRYO HEPATOCYTES INVIVO AND IN CULTURE - EFFECT OF PORPHYRINOGENIC DRUGS AND HEME	86	11
2483	5	6152 1988 CARCINOGENESIS 9(11):1935-1941 GRAHAM MJ; LUCIER GW; LINKO P; MARONPOT RR; GOLDSTEIN JA INCREASES IN CYTOCHROME-P-450 MEDIATED 17-BETA-ESTRADIOL 2- HYDROXYLASE ACTIVITY IN RAT-LIVER MICROSOMES AFTER BOTH ACUTE ADMINISTRATION AND SUBCHRONIC ADMINISTRATION OF 2,3,7,8- TETRACHLORODIBENZO-P-DIOXIN IN A 2-STAGE HEPATOCARCINOGENESIS MODEL	66	11
2484	8	6197 1988 EUROPEAN JOURNAL OF BIOCHEMISTRY 174(1):31-36 STANLEY LA; ADAMS DJ; LINDSAY R; MEEHAN RR; LIAO W; WOLF CR POTENTIATION AND SUPPRESSION OF MOUSE-LIVER CYTOCHROME-P-450 ISOZYMES DURING THE ACUTE-PHASE RESPONSE INDUCED BY BACTERIAL- ENDOTOXIN	65	11
2485	3	6405 1989 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 160(1):46-52 BARTLOMOWICZ B; FRIEDBERG T; UTESCH D; MOLITOR E; PLATT K; OESCH F REGIOSELECTIVE AND STEREOSELECTIVE REGULATION OF MONOOXYGENASE ACTIVITIES BY ISOENZYME-SELECTIVE PHOSPHORYLATION OF CYTOCHROME-P450	24	11
2486	5	6447 1989 BIOCHEMICAL PHARMACOLOGY 38(22):4027-4036 YANG HYL; NAMKUNG MJ; JUCHAU MR IMMUNODETECTION, IMMUNOINHIBITION, IMMUNOQUANTITATION AND BIOCHEMICAL ANALYSES OF CYTOCHROME-P-450IA1 IN TISSUES OF THE RAT CONCEPTUS DURING THE PROGRESSION OF ORGANOGENESIS	24	11
2487	5	6610 1989 HUMAN GENETICS 81(2):171-174 SPURR NK; GOUGH AC; STEVENSON K; WOLF CR THE HUMAN CYTOCHROME-P450 CYP3 LOCUS - ASSIGNMENT TO CHROMOSOME 7Q22-QTER	15	11
2488	2	6611 1989 HUMAN GENETICS 82(3):285-286 KAGIMOTO K; WATERMAN MR; KAGIMOTO M; FERREIRA P; SIMPSON ER; WINTER JSD IDENTIFICATION OF A COMMON MOLECULAR-BASIS FOR COMBINED 17- ALPHA-HYDROXYLASE 17,20-LYASE DEFICIENCY IN 2 MENNONITE FAMILIES	28	11
2489	3	6639 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(17):10292-10298 TRABER PG; MAGANTO P; WOJCIK E; KEREN D; GUMUCIO JJ INDUCTION OF P-450IIB GENES WITHIN THE RAT-LIVER ACINUS IS NOT DEPENDENT ON THE CHEMICAL INDUCER OR ON THE ACINAR ORGANIZATION	27	11
2490	10	6671 1989 JOURNAL OF MEDICINAL CHEMISTRY 32(10):2231-2239 VANWAUWE JP; JANSSEN PAJ IS THERE A CASE FOR P-450 INHIBITORS IN CANCER-TREATMENT	79	11
2491	14	6693 1989 MECHANISMS OF AGEING AND DEVELOPMENT 48(2):145-155 LEAKEY JEA; CUNNY HC; BAZARE J; WEBB PJ; FEUERS RJ; DUFFY PH; HART RW EFFECTS OF AGING AND CALORIC RESTRICTION ON HEPATIC DRUG- METABOLIZING ENZYMES IN THE FISCHER-344 RAT .1. THE CYTOCHROME- P-450 DEPENDENT MONOOXYGENASE SYSTEM	80	11
2492	8	6713 1989 MOLECULAR PHARMACOLOGY 35(5):626-634 RIDDICK DS; PARK SS; GELBOIN HV; MARKS GS EFFECTS OF A SERIES OF 4-ALKYL ANALOGS OF 3,5-DIETHOXYCARBONYL- 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE ON THE MAJOR INDUCIBLE CYTOCHROME-P-450 ISOZYMES OF RAT-LIVER	21	11
2493	8	6749 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(3):835-839 COGHLAN VM; VICKERY LE EXPRESSION OF HUMAN FERREDOXIN AND ASSEMBLY OF THE [2FE-2S] CENTER IN ESCHERICHIA-COLI	65	11
2494	7	6751 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(17):6582-6586 MOREL Y; BRISTOW J; GITELMAN SE; MILLER WL TRANSCRIPT ENCODED ON THE OPPOSITE STRAND OF THE HUMAN STEROID 21-HYDROXYLASE COMPLEMENT COMPONENT C4-GENE LOCUS	110	11
2495	7	6812 1990 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2(6):493-501 STRUM JM; ITO T; PHILPOT RM; DESANTI AM; MCDOWELL EM THE IMMUNOCYTOCHEMICAL DETECTION OF CYTOCHROME-P-450 MONOOXYGENASE IN THE LUNGS OF FETAL, NEONATAL, AND ADULT HAMSTERS	29	11
2496	7	6823 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 276(2):442-450 ROBERTS EA; JOHNSON KC; HARPER PA; OKEY AB CHARACTERIZATION OF THE AH RECEPTOR MEDIATING ARYL-HYDROCARBON HYDROXYLASE INDUCTION IN THE HUMAN LIVER-CELL LINE HEP G2	55	11
2497	12	6825 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 277(1):8-16 MARCUS CB; WILSON NM; JEFCOATE CR; WILKINSON CF; OMIECINSKI CJ SELECTIVE INDUCTION OF CYTOCHROME-P450 ISOZYMES IN RAT-LIVER BY 4-NORMAL-ALKYL-METHYLENEDIOXYBENZENES	26	11
2498	4	6873 1990 BIOCHEMICAL PHARMACOLOGY 39(3):463-469 FUKUHARA M; MIZOKAMI K; SAKAGUCHI M; NIIMURA Y; KATO K; INOUYE S; TAKANAKA A AFLATOXIN-B1-SPECIFIC CYTOCHROME-P-450 ISOZYME (P-450-AFB) INDUCIBLE BY 3-METHYLCHOLANTHRENE IN GOLDEN-HAMSTERS	18	11
2499	6	6882 1990 BIOCHEMICAL PHARMACOLOGY 39(12):1991-1998 KELLEY M; WOMACK J; SAFE S EFFECTS OF CYTOCHROME-P-450 MONOOXYGENASE INDUCERS ON MOUSE HEPATIC-MICROSOMAL METABOLISM OF TESTOSTERONE AND ALKOXYRESORUFINS	22	11
2500	7	7011 1990 DNA AND CELL BIOLOGY 9(1):37-48 ZHAO J; CHAN G; GOVIND S; BELL P; KEMPER B STRUCTURE OF 5' REGIONS AND EXPRESSION OF PHENOBARBITAL- INDUCIBLE RABBIT CYTOCHROME-P450IIC GENES	21	11

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