#	Cited nodes	Nodes / Authors	GCS	LCS
1601	9	3251 1977 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 184(1):276-281 BARTOLI GM; GALEOTTI T; PALOMBINI G; PARISI G; AZZI A DIFFERENT CONTRIBUTION OF RAT-LIVER MICROSOMAL PIGMENTS IN FORMATION OF SUPEROXIDE ANIONS AND HYDROGEN-PEROXIDE DURING DEVELOPMENT	49	17
1602	10	3522 1978 BIOCHEMICAL PHARMACOLOGY 27(8):1203-1209 LESCA P; LECOINTE P; PAOLETTI C; MANSUY D ELLIPTICINES AS POTENT INHIBITORS OF ARYL-HYDROCARBON HYDROXYLASE - THEIR BINDING TO MICROSOMAL CYTOCHROMES P450 AND PROTECTIVE EFFECT AGAINST BENZO(A)PYRENE MUTAGENICITY	78	17
1603	13	3593 1978 EUROPEAN JOURNAL OF BIOCHEMISTRY 88(1):37-47 FEYEREISEN R; DURST F ECDYSTERONE BIOSYNTHESIS - MICROSOMAL CYTOCHROME-P-450-LINKED ECDYSONE 20-MONOOXYGENASE FROM TISSUES OF AFRICAN MIGRATORY LOCUST	91	17
1604	11	3620 1978 JOURNAL OF BIOCHEMISTRY 83(1):249-260 OHASHI M; OMURA T PRESENCE OF NADPH-CYTOCHROME P-450 REDUCTASE SYSTEM IN LIVER AND KIDNEY MITOCHONDRIA	33	17
1605	9	4505 1982 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 216(1):322-328 SCHWARZ D; PIRRWITZ J; RUCKPAUL K ROTATIONAL DIFFUSION OF CYTOCHROME-P-450 IN THE MICROSOMAL MEMBRANE - EVIDENCE FOR A CLUSTERLIKE ORGANIZATION FROM SATURATION TRANSFER ELECTRON-PARAMAGNETIC RESONANCE SPECTROSCOPY	31	17
1606	11	4642 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(21):2696-2704 BUMPUS JA; DUS KM BOVINE ADRENOCORTICAL MICROSOMAL HEMEPROTEINS-P-45017-ALPHA AND P-450C-21 - ISOLATION, PARTIAL CHARACTERIZATION, AND COMPARISON TO P-450SCC	33	17
1607	10	4681 1982 LABORATORY INVESTIGATION 47(5):412-426 FREEMAN BA; CRAPO JD FREE-RADICALS AND TISSUE-INJURY	2010	17
1608	16	4734 1982 XENOBIOTICA 12(11):773-786 WATERMAN MR ACTH-MEDIATED INDUCTION OF SYNTHESIS AND ACTIVITY OF CYTOCHROME-P-450S AND RELATED ENZYMES IN CULTURED BOVINE ADRENOCORTICAL-CELLS	25	17
1609	9	4919 1983 JOURNAL OF BIOLOGICAL CHEMISTRY 258(14):8623-8629 DEMONTELLANO PRO; AUGUSTO O; VIOLA F; KUNZE KL CARBON RADICALS IN THE METABOLISM OF ALKYL HYDRAZINES	77	17
1610	22	5125 1984 EUROPEAN JOURNAL OF BIOCHEMISTRY 144(3):509-513 BLANCK J; SMETTAN G; RISTAU O; INGELMANSUNDBERG M; RUCKPAUL K MECHANISM OF RATE CONTROL OF THE NADPH-DEPENDENT REDUCTION OF CYTOCHROME-P-450 BY LIPIDS IN RECONSTITUTED PHOSPHOLIPID- VESICLES	31	17
1611	26	5170 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(5):2991-2999 KOMINAMI S; HARA H; OGISHIMA T; TAKEMORI S INTERACTION BETWEEN CYTOCHROME-P-450 (P-450C21) AND NADPH- CYTOCHROME-P-450 REDUCTASE FROM ADRENOCORTICAL MICROSOMES IN A RECONSTITUTED SYSTEM	43	17
1612	9	5642 1986 ENDOCRINOLOGY 118(4):1366-1374 RODGERS RJ; WATERMAN MR; SIMPSON ER CYTOCHROME-P-450SCC, CYTOCHROME-P-45017-ALPHA, ADRENODOXIN, AND REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE-CYTOCHROME- P-450 REDUCTASE IN BOVINE FOLLICLES AND CORPORA-LUTEA - CHANGES IN SPECIFIC CONTENTS DURING THE OVARIAN CYCLE	108	17
1613	10	5746 1987 ACCOUNTS OF CHEMICAL RESEARCH 20(8):289-294 DEMONTELLANO PRO CONTROL OF THE CATALYTIC ACTIVITY OF PROSTHETIC HEME BY THE STRUCTURE OF HEMOPROTEINS	215	17
1614	13	5973 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(20):6990-6994 BALLOU LR; LAM BK; WONG PYK; CHEUNG WY FORMATION OF CIS-14,15-OXIDO-5,8,11-ICOSATRIENOIC ACID FROM PHOSPHATIDYLINOSITOL IN HUMAN-PLATELETS	28	17
1615	8	6237 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(27):13544-13548 STAYTON PS; FISHER MT; SLIGAR SG DETERMINATION OF CYTOCHROME-B5 ASSOCIATION REACTIONS - CHARACTERIZATION OF METMYOGLOBIN AND CYTOCHROME-P-450CAM BINDING TO GENETICALLY ENGINEERED CYTOCHROME-B5	49	17
1616	1	6419 1989 BIOCHEMICAL JOURNAL 259(2):315-324 SMITH WL THE EICOSANOIDS AND THEIR BIOCHEMICAL-MECHANISMS OF ACTION	532	17
1617	11	6460 1989 BIOCHEMISTRY 28(10):4499-4504 TINDBERG N; INGELMANSUNDBERG M CYTOCHROME-P-450 AND OXYGEN-TOXICITY - OXYGEN-DEPENDENT INDUCTION OF ETHANOL-INDUCIBLE CYTOCHROME-P-450 (IIE1) IN RAT- LIVER AND LUNG	60	17
1618	12	6620 1989 JOURNAL OF BIOCHEMICAL TOXICOLOGY 4(1):1-6 PLATT KL; MOLITOR E; DOHMER J; DOGRA S; OESCH F GENETICALLY ENGINEERED V79 CHINESE-HAMSTER CELL EXPRESSION OF PURIFIED CYTOCHROME-P-450IIB1 MONOOXYGENASE ACTIVITY	53	17
1619	8	6658 1989 JOURNAL OF CLINICAL INVESTIGATION 83(2):527-536 MOREL Y; ANDRE J; URINGLAMBERT B; HAUPTMANN G; BETUEL H; TOSSI M; FOREST MG; DAVID M; BERTRAND J; MILLER WL REARRANGEMENTS AND POINT MUTATIONS OF P450C21 GENES ARE DISTINGUISHED BY 5 RESTRICTION ENDONUCLEASE HAPLOTYPES IDENTIFIED BY A NEW PROBING STRATEGY IN 57 FAMILIES WITH CONGENITAL ADRENAL-HYPERPLASIA	106	17
1620	15	6677 1989 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 251(2):790-796 SCHNIER GG; LAETHEM CL; KOOP DR IDENTIFICATION AND INDUCTION OF CYTOCHROME-P450, CYTOCHROME- P450IIE1 AND CYTOCHROME-P450IA1 IN RABBIT BONE-MARROW	57	17
1621	10	6805 1990 ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 14(4):590-594 LUCAS D; BERTHOU F; DREANO Y; FLOCH HH; MENEZ JF ETHANOL-INDUCIBLE CYTOCHROME-P-450 - ASSESSMENT OF SUBSTRATES SPECIFIC CHEMICAL PROBES IN RAT-LIVER MICROSOMES	32	17
1622	9	6859 1990 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 172(3):1180-1188 RIFKIND AB; GANNON M; GROSS SS ARACHIDONIC-ACID METABOLISM BY DIOXIN-INDUCED CYTOCHROME-P-450 - A NEW HYPOTHESIS ON THE ROLE OF P-450 IN DIOXIN TOXICITY	42	17
1623	3	7043 1990 ENDOCRINOLOGY 126(5):2493-2498 LORENCE MC; MURRY BA; TRANT JM; MASON JI HUMAN 3-BETA-HYDROXYSTEROID DEHYDROGENASE DELTA-5-]4-ISOMERASE FROM PLACENTA - EXPRESSION IN NONSTEROIDOGENIC CELLS OF A PROTEIN THAT CATALYZES THE DEHYDROGENATION ISOMERIZATION OF C21 AND C19 STEROIDS	157	17
1624	10	7237 1990 MOLECULAR PHARMACOLOGY 37(6):810-819 TRABER PG; WANG W; MCDONNELL M; GUMUCIO JJ P450IIB-GENE EXPRESSION IN RAT SMALL-INTESTINE - CLONING OF INTESTINAL P450IIB1 MESSENGER-RNA USING THE POLYMERASE CHAIN- REACTION AND TRANSCRIPTIONAL REGULATION OF INDUCTION	45	17
1625	8	7242 1990 MOLECULAR PHARMACOLOGY 38(3):313-318 CRAIG PI; MEHTA I; MURRAY M; MCDONALD D; ASTROM A; VANDERMEIDE PH; FARRELL GC INTERFERON DOWN REGULATES THE MALE-SPECIFIC CYTOCHROME- P450IIIA2 IN RAT-LIVER	61	17
1626	8	7359 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 285(1):120-125 DING XX; PORTER TD; PENG HM; COON MJ CDNA AND DERIVED AMINO-ACID-SEQUENCE OF RABBIT NASAL CYTOCHROME P450NMB (P450IIG1), A UNIQUE ISOZYME POSSIBLY INVOLVED IN OLFACTION	37	17
1627	24	7374 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 291(2):231-240 EBERHART DC; PARKINSON A CYTOCHROME-P450 IIIA1 (P450P) REQUIRES CYTOCHROME-B5 AND PHOSPHOLIPID WITH UNSATURATED FATTY-ACIDS	28	17
1628	1	7394 1991 BIOCHEMICAL JOURNAL 274():409-414 MEYER DJ; COLES B; PEMBLE SE; GILMORE KS; FRASER GM; KETTERER B THETA, A NEW CLASS OF GLUTATHIONE TRANSFERASES PURIFIED FROM RAT AND MAN	610	17
1629	5	7402 1991 BIOCHEMICAL PHARMACOLOGY 41(3):395-404 NAKAJIMA T; WANG RS; ELOVAARA E; PARK SS; GELBOIN HV; HIETANEN E; VAINIO H MONOCLONAL ANTIBODY-DIRECTED CHARACTERIZATION OF CYTOCHROME- P450 ISOZYMES RESPONSIBLE FOR TOLUENE METABOLISM IN RAT-LIVER	68	17
1630	31	7478 1991 CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 69(5):537-549 PARKE DV; IOANNIDES C; LEWIS DFV THE 1990 PHARMACEUTICAL-MANUFACTURERS-ASSOCIATION-OF-CANADA KEYNOTE LECTURE - THE ROLE OF THE CYTOCHROMES-P450 IN THE DETOXICATION AND ACTIVATION OF DRUGS AND OTHER CHEMICALS	48	17
1631	14	7556 1991 EUROPEAN JOURNAL OF BIOCHEMISTRY 196(3):531-536 YOKOTANI N; KUSUNOSE E; SOGAWA K; KAWASHIMA H; KINOSAKI M; KUSUNOSE M; FUJIIKURIYAMA Y CDNA CLONING AND EXPRESSION OF THE MESSENGER-RNA FOR CYTOCHROME P-450KD WHICH SHOWS A FATTY-ACID OMEGA-HYDROXYLATING ACTIVITY	26	17
1632	7	7560 1991 EUROPEAN JOURNAL OF BIOCHEMISTRY 198(2):383-389 RONIS MJJ; JOHANSSON I; HULTENBY K; LAGERCRANTZ J; GLAUMANN H; INGELMANSUNDBERG M ACETONE-REGULATED SYNTHESIS AND DEGRADATION OF CYTOCHROME- P4502E2 AND CYTOCHROME-P4502B1 IN RAT-LIVER	53	17
1633	8	7572 1991 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 41(6):573-578 GASCON MP; DAYER P INVITRO FORECASTING OF DRUGS WHICH MAY INTERFERE WITH THE BIOTRANSFORMATION OF MIDAZOLAM	85	17
1634	32	7600 1991 JAPANESE JOURNAL OF CANCER RESEARCH 82(12):1325-1335 KAWAJIRI K; FUJIIKURIYAMA Y P450 AND HUMAN CANCER	71	17
1635	13	7607 1991 JOURNAL OF BIOCHEMISTRY 109(5):711-717 YASUMORI T; YAMAZOE Y; KATO R CYTOCHROME-P-450 HUMAN-2 (P-450IIC9) IN MEPHENYTOIN HYDROXYLATION POLYMORPHISM IN HUMAN LIVERS - DIFFERENCES IN SUBSTRATE AND STEREOSELECTIVITIES AMONG MICROHETEROGENEOUS P- 450IIC SPECIES EXPRESSED IN YEASTS	33	17
1636	7	7633 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(26):17031-17039 HAHN CN; HANSEN AJ; MAY BK TRANSCRIPTIONAL REGULATION OF THE CHICKEN CYP2H1 GENE - LOCALIZATION OF A PHENOBARBITAL-RESPONSIVE ENHANCER DOMAIN	42	17
1637	8	7690 1991 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 113(21):8146-8153 SWANSON BA; DEMONTELLANO PRO STRUCTURE AND ABSOLUTE STEREOCHEMISTRY OF THE 4 N- PHENYLPROTOPORPHYRIN-IX REGIOISOMERS ISOLATED FROM PHENYLHYDRAZINE-TREATED MYOGLOBIN	38	17
1638	11	7729 1991 MOLECULAR PHARMACOLOGY 39(6):811-817 MURAYAMA N; SHIMADA M; YAMAZOE Y; KATO R DIFFERENCE IN THE SUSCEPTIBILITY OF 2 PHENOBARBITAL-INDUCIBLE FORMS, P450IIB1 AND P450IIB2, TO THYROID HORMONE-INDUCED AND GROWTH HORMONE-INDUCED SUPPRESSION IN RAT-LIVER - PHENOBARBITAL-INDUCIBLE P450IIB2 SUPPRESSION BY THYROID-HORMONE ACTING DIRECTLY, BUT NOT THROUGH THE PITUITARY SYSTEM	50	17
1639	11	7739 1991 MUTATION RESEARCH 247(2):267-281 NEBERT DW ROLE OF GENETICS AND DRUG-METABOLISM IN HUMAN CANCER RISK	153	17
1640	9	7864 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 294(2):654-661 PETERSON JA; BODDUPALLI SS P450BM-3 - REDUCTION BY NADPH AND SODIUM DITHIONITE	21	17
1641	24	7896 1992 BIOCHEMICAL JOURNAL 281():689-695 FREEMAN JE; STIRLING D; RUSSELL AL; WOLF CR CDNA SEQUENCE, DEDUCED AMINO-ACID-SEQUENCE, PREDICTED GENE STRUCTURE AND CHEMICAL-REGULATION OF MOUSE CYP2E1	37	17
1642	7	7935 1992 BIOCHEMISTRY 31(13):3364-3370 HANIOKA N; GONZALEZ FJ; LINDBERG NA; LIU G; GELBOIN HV; KORZEKWA KR SITE-DIRECTED MUTAGENESIS OF CYTOCHROME-P450S CYP2A1 AND CYP2A2 - INFLUENCE OF THE DISTAL HELIX ON THE KINETICS OF TESTOSTERONE HYDROXYLATION	30	17
1643	11	8045 1992 DNA AND CELL BIOLOGY 11(10):767-780 SEGHEZZI W; MEILI C; RUFFINER R; KUENZI R; SANGLARD D; FIECHTER A IDENTIFICATION AND CHARACTERIZATION OF ADDITIONAL MEMBERS OF THE CYTOCHROME-P450 MULTIGENE FAMILY CYP52 OF CANDIDA- TROPICALIS	23	17
1644	6	8251 1992 LIFE SCIENCES 51(8):575-581 ZHAO J; LEEMANN T; DAYER P INVITRO OXIDATION OF OXICAM NSAIDS BY A HUMAN LIVER CYTOCHROME- P450	46	17
1645	9	8414 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 306(2):521-527 STRAUB P; JOHNSON EF; KEMPER B HYDROPHOBIC SIDE-CHAIN REQUIREMENTS FOR LAURIC ACID AND PROGESTERONE HYDROXYLATION AT AMINO ACID-113 IN CYTOCHROME- P450-2C2, A POTENTIAL DETERMINANT OF SUBSTRATE-SPECIFICITY	28	17
1646	5	8545 1993 CARCINOGENESIS 14(1):85-88 HIRVONEN A; HUSGAFVELPURSIAINEN K; ANTTILA S; KARJALAINEN A; VAINIO H THE HUMAN CYP2E1 GENE AND LUNG-CANCER - DRAI AND RSAI RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS IN A FINNISH STUDY POPULATION	99	17
1647	11	8586 1993 DRUG METABOLISM AND DISPOSITION 21(1):43-49 EUGSTER HP; PROBST M; WURGLER FE; SENGSTAG C CAFFEINE, ESTRADIOL, AND PROGESTERONE INTERACT WITH HUMAN CYP1A1 AND CYP1A2 - EVIDENCE FROM CDNA-DIRECTED EXPRESSION IN SACCHAROMYCES-CEREVISIAE	50	17
1648	15	8647 1993 HEPATOLOGY 17(2):236-245 TAKAHASHI T; LASKER JM; ROSMAN AS; LIEBER CS INDUCTION OF CYTOCHROME P-4502E1 IN THE HUMAN LIVER BY ETHANOL IS CAUSED BY A CORRESPONDING INCREASE IN ENCODING MESSENGER-RNA	116	17
1649	12	9049 1994 CHEMICAL RESEARCH IN TOXICOLOGY 7(3):434-442 LECOEUR S; BONIERBALE E; CHALLINE D; GAUTIER JC; VALADON P; DANSETTE PM; CATINOT R; BALLET F; MANSUY D; BEAUNE PH SPECIFICITY OF IN-VITRO COVALENT BINDING OF TIENILIC ACID METABOLITES TO HUMAN LIVER-MICROSOMES IN RELATIONSHIP TO THE TYPE OF HEPATOTOXICITY - COMPARISON WITH 2 DIRECTLY HEPATOTOXIC DRUGS	58	17
1650	19	9225 1994 JOURNAL OF CLINICAL PSYCHIATRY 55(12):38-45 DEVANE CL PHARMACOGENETICS AND DRUG-METABOLISM OF NEWER ANTIDEPRESSANT AGENTS	91	17
1651	17	9295 1994 MOLECULAR ENDOCRINOLOGY 8(3):392-402 LIN D; ZHANG LH; CHIAO E; MILLER WL MODELING AND MUTAGENESIS OF THE ACTIVE-SITE OF HUMAN P450C17	39	17
1652	23	9439 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 318(2):446-456 PERNECKY SJ; OLKEN NM; BESTERVELT LL; COON MJ SUBCELLULAR-LOCALIZATION, AGGREGATION STATE, AND CATALYTIC ACTIVITY OF MICROSOMAL P450 CYTOCHROMES MODIFIED IN THE NH2- TERMINAL REGION AND EXPRESSED IN ESCHERICHIA-COLI	42	17
1653	23	9462 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 323(2):295-302 ROBERTS ES; HOPKINS NE; ZALUZEC EJ; GAGE DA; ALWORTH WL; HOLLENBERG PF MECHANISM-BASED INACTIVATION OF CYTOCHROME-P450 2B1 BY 9- ETHYNYLPHENANTHRENE	36	17
1654	17	9510 1995 BIOCHEMISTRY 34(25):8028-8036 IBEANU GC; GOLDSTEIN JA TRANSCRIPTIONAL REGULATION OF HUMAN CYP2C GENES - FUNCTIONAL COMPARISON OF CYP2C9 AND CYP2C18 PROMOTER REGIONS	24	17
1655	21	9690 1995 GUT 36(2):259-267 MCKINNON RA; BURGESS WM; HALL PDLM; ROBERTSTHOMSON SJ; GONZALEZ FJ; MCMANUS ME CHARACTERIZATION OF CYP3A GENE SUBFAMILY EXPRESSION IN HUMAN GASTROINTESTINAL TISSUES	47	17
1656	13	9762 1995 JOURNAL OF MOLECULAR EVOLUTION 41(6):894-900 Hoffman SMG; FernandezSalguero P; Gonzalez FJ; Mohrenweiser HW Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19	39	17
1657	45	9846 1995 PHARMACOLOGY & THERAPEUTICS 68(3):385-424 Park BK; Pirmohamed M; Kitteringham NR The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity	48	17
1658	6	10136 1996 CYTOCHROME P450, PT B 272():315-326 GrahamLorence SE; Peterson JA Structural alignments of P450s and extrapolations to the unknown	38	17
1659	18	10155 1996 DRUG METABOLISM AND DISPOSITION 24(8):884-890 Su T; Sheng JJ; Lipinskas TW; Ding XX Expression of CYP2A genes in rodent and human nasal mucosa	37	17
1660	16	10156 1996 DRUG METABOLISM AND DISPOSITION 24(8):899-905 Huang ZQ; Fasco MJ; Figge HL; Keyomarsi K; Kaminsky LS Expression of cytochromes P450 in human breast tissue and tumors	67	17
1661	16	10518 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 348(1):107-115 Shaw PM; Hosea NA; Thompson DV; Lenius JM; Guengerich FP Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5)	33	17
1662	13	10751 1997 JOURNAL OF BIOLOGICAL CHEMISTRY 272(31):19176-19186 Urban P; Mignotte C; Kazmaier M; Delorme F; Pompon D Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-Cytochrome P450 reductases with P450 CYP73A5	54	17
1663	6	10809 1997 JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS 93(9):1769-1774 Zhang Z; Nassar AEF; Lu ZQ; Schenkman JB; Rusling JF Direct electron injection from electrodes to cytochrome P450(cam) in biomembrane-like films	62	17
1664	20	11360 1998 PHARMACOGENETICS 8(2):137-155 Maenpaa J; Hall SD; Ring BJ; Strom SC; Wrighton SA Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone	47	17
1665	17	11460 1999 ANALYTICAL BIOCHEMISTRY 269(2):359-366 Schwaneberg U; Schmidt-Dannert C; Schmitt J; Schmid RD A continuous spectrophotometric assay for P450 BM-3, a fatty acid hydroxylating enzyme, and its mutant F87A	21	17
1666	26	11957 2000 BIOCHEMISTRY 39(20):5929-5939 Hosea NA; Miller GP; Guengerich FP Elucidation of distinct ligand binding sites for cytochrome P450 3A4	53	17
1667	17	12012 2000 CLINICAL PHARMACOLOGY & THERAPEUTICS 67(1):48-56 Sata F; Sapone A; Elizondo G; Stocker P; Miller VP; Zheng W; Raunio H; Crespi CL; Gonzalez FJ CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity	69	17
1668	19	12578 2001 MOLECULAR PHARMACOLOGY 59(2):386-392 Domanski TL; Finta C; Halpert JR; Zaphiropoulos PG cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450	38	17
1669	4	55 1959 BIOCHIMICA ET BIOPHYSICA ACTA 31(1):34-46 GREEN DE; JARNEFELT J; TISDALE HD STUDIES ON THE ELECTRON TRANSPORT SYSTEM .14. THE ISOLATION AND PROPERTIES OF SOLUBLE CYTOCHROME-C1	84	16
1670	5	72 1959 PLANT PHYSIOLOGY 34(1):33-49 CHANCE B; HACKETT DP THE ELECTRON TRANSFER SYSTEM OF SKUNK CABBAGE MITOCHONDRIA	58	16
1671	8	119 1961 ANNUAL REVIEW OF ENTOMOLOGY 6():103-& SACKTOR B ROLE OF MITOCHONDRIA IN RESPIRATORY METABOLISM OF FLIGHT MUSCLE	50	16
1672	5	321 1964 JOURNAL OF BIOLOGICAL CHEMISTRY 239(6):2049-& MINAKAMI S; ESTABROOK RW; SCHINDLER FJ HYDROGEN TRANSFER BETWEEN REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE DEHYDROGENASE + RESPIRATORY CHAIN .2. INITIAL LAG IN OXIDATION OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE	16	16
1673	9	369 1965 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 21(5):497-& FRENKEL R DPNH OSCILLATIONS IN GLYCOLYZING CELL FREE EXTRACTS FROM BEEF HEART	31	16
1674	2	427 1965 JOURNAL OF BIOLOGICAL CHEMISTRY 240(10):4081-& MASTERS BSS; BILIMORI.MH; KAMIN H; GIBSON QH MECHANISM OF 1- AND 2-ELECTRON TRANSFERS CATALYZED BY REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME C REDUCTASE	80	16
1675	4	484 1966 BIOCHEMISTRY 5(7):2326-& COCKRELL RS; HARRIS EJ; PRESSMAN BC ENERGETICS OF POTASSIUM TRANSPORT IN MITOCHONDRIA INDUCED BY VALINOMYCIN	176	16
1676	5	541 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(20):4771-& PHARO RL; SORDAHL LA; VYAS SR; SANADI DR STUDIES ON DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE UBIQUINONE REDUCTASE .I. ASSAY OF UBIQUINONE REDUCTASE ACTIVITY IN SUBMITOCHONDRIAL PARTICLES AND EXTRACTS	46	16
1677	3	635 1967 BIOCHEMISTRY 6(9):2794-& HALL PF ELECTRON TRANSPORT IN RELATION TO STEROID BIOSYNTHESIS . INHIBITION OF SIDE-CHAIN CLEAVAGE OF CHOLESTEROL BY HYPERBARIC OXYGEN	24	16
1678	3	993 1969 BIOCHEMICAL JOURNAL 111(1):27-& DAWSON AP; THORNE CJR PREPARATION AND SOME PROPERTIES OF L-3-GLYCEROPHOSPHATE DEHYDROGENASE FROM PIG BRAIN MITOCHONDRIA	30	16
1679	9	1022 1969 BIOCHEMISTRY 8(12):4956-& SWEAT ML; DUTCHER JS; YOUNG RB; BRYSON MJ ADRENAL GLAND STEROID C-21 CYTOCHROME P-450 REDUCTASE	22	16
1680	13	1050 1969 CANADIAN JOURNAL OF BOTANY 47(2):271-& PYE EK BIOCHEMICAL MECHANISMS UNDERLYING METABOLIC OSCILLATIONS IN YEAST	89	16
1681	6	1188 1970 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 174(1):205-& COOPER DY; SCHLEYER H; ROSENTHA.O SOME CHEMICAL PROPERTIES OF CYTOCHROME P-450 AND ITS CARBON MONOXIDE COMPOUND (P-450.CO)	33	16
1682	4	1369 1970 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 174(2):197-& CATZ CS; JUCHAU MR; YAFFE SJ EFFECTS OF IRON, RIBOFLAVIN AND IODIDE DEFICIENCIES ON HEPATIC DRUG-METABOLIZING ENZYME SYSTEMS	65	16
1683	1	1451 1971 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 145(1):194-& MACKLER B; HAYNES B; TATTONI DS; TIPPIT DF; KELLEY VC STUDIES OF ADRENAL STEROID HYDROXYLATION .1. PURIFICATION OF MICROSOMAL 21-HYDROXYLASE SYSTEM	22	16
1684	10	1466 1971 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42(3):413-& LEBEAULT JM; LODE ET; COON MJ FATTY ACID AND HYDROCARBON HYDROXYLATION IN YEAST - ROLE OF CYTOCHROME P-450 IN CANDIDA-TROPICALIS	87	16
1685	15	1580 1971 EUROPEAN JOURNAL OF BIOCHEMISTRY 22(4):489-& SIMPSON ER; BOYD GS METABOLISM OF PYRUVATE BY BOVINE-ADRENAL-CORTEX MITOCHONDRIA	25	16
1686	3	1644 1971 JOURNAL OF MEDICINAL CHEMISTRY 14(9):777-& MARTIN YC; HANSCH C INFLUENCE OF HYDROPHOBIC CHARACTER ON RELATIVE RATE OF OXIDATION OF DRUGS BY RAT LIVER MICROSOMES	66	16
1687	14	1650 1971 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 176(1):1-& ALVARES AP; SCHILLIN.G; LEVIN W; KUNTZMAN R INABILITY OF SUBSTRATES TO ALTER CARBON MONOXIDE AND ETHYL ISOCYANIDE DIFFERENCE SPECTRA OF MICROSOMAL HEMOPROTEIN	22	16
1688	9	1656 1971 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 179(1):91-& FOUTS JR; POHL RJ FURTHER STUDIES ON EFFECTS OF METAL IONS ON RAT LIVER MICROSOMAL REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE- CYTOCHROME P-450 REDUCTASE	41	16
1689	19	1673 1971 MOLECULAR PHARMACOLOGY 7(3):280-& MITANI F; ALVARES AP; SASSA S; KAPPAS A PREPARATION AND PROPERTIES OF A SOLUBILIZED FORM OF CYTOCHROME P-450 FROM CHICK EMBRYO LIVER MICROSOMES	29	16
1690	8	2078 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 50(2):524-531 SAUER LA NAD-DEPENDENT MALIC ENZYME AND NADP-DEPENDENT MALIC ENZYME WITH REGULATORY PROPERTIES IN RAT-LIVER AND ADRENAL-CORTEX MITOCHONDRIAL FRACTIONS	61	16
1691	24	2293 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(20):7263-7271 CHENG SC; HARDING BW SUBSTRATE-INDUCED DIFFERENCE SPECTRAL, ELECTRON-PARAMAGNETIC RESONANCE, AND ENZYMATIC PROPERTIES OF CHOLESTEROL-DEPLETED MITOCHONDRIAL CYTOCHROME-P-450 OF BOVINE ADRENAL-CORTEX	38	16
1692	18	2297 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(23):8150-8156 FUJITA T; MANNERIN.GJ ELECTRON-TRANSPORT COMPONENTS OF HEPATIC MICROSOMES - SOLUBILIZATION, RESOLUTION, AND RECOMBINATION TO RECONSTITUTE ANILINE HYDROXYLASE-ACTIVITY	53	16
1693	6	2332 1973 MOLECULAR PHARMACOLOGY 9(5):670-675 THURMAN RG INDUCTION OF HEPATIC MICROSOMAL REDUCED NICOTINAMIDE ADENINE- DINUCLEOTIDE PHOSPHATE-DEPENDENT PRODUCTION OF HYDROGEN- PEROXIDE BY CHRONIC PRIOR TREATMENT WITH ETHANOL	83	16
1694	5	2363 1973 TOXICOLOGY AND APPLIED PHARMACOLOGY 24(1):1-19 CASTRO JA; FERREYRA EC; CASTRO CRD; GOMEZ MID; DACOSTA N; FENOS OMD STUDIES ON MECHANISM OF CYSTAMINE PREVENTION OF SEVERAL LIVER STRUCTURAL AND BIOCHEMICAL ALTERATIONS CAUSED BY CARBON- TETRACHLORIDE	79	16
1695	20	2495 1974 DRUG METABOLISM AND DISPOSITION 2(3):285-292 COHEN GM; MANNERIN.GJ SEX-DEPENDENT DIFFERENCES IN DRUG-METABOLISM IN RAT .3. TEMPORAL CHANGES IN TYPE-I BINDING AND NADPH-CYTOCHROME, P-450 REDUCTASE DURING SEXUAL-MATURATION	27	16
1696	19	2747 1975 BIOCHIMICA ET BIOPHYSICA ACTA 410(1):32-44 CINTI DL; OZOLS J BINDING OF HOMOGENEOUS CYTOCHROME-B5 TO RAT-LIVER MICROSOMES - EFFECT ON N-DEMETHYLATION REACTIONS	23	16
1697	6	2975 1976 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 73(1):171-179 CINTI DL; FEINSTEIN MB PLATELET CYTOCHROME-P-450 - POSSIBLE ROLE IN ARACHIDONATE- INDUCED AGGREGATION	37	16
1698	8	2976 1976 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 73(3):555-561 RYDSTROM J; GUSTAFSSON JA; INGELMANSUNDBERG M; MONTELIUS J; ERNSTER L TOPOLOGY OF MITOCHONDRIAL 11-BETA-HYDROXYLASE SYSTEM IN BOVINE ADRENAL-CORTEX	25	16
1699	23	3254 1977 ARCHIVES OF TOXICOLOGY 39(1-2):41-50 ULLRICH V; KREMERS P MULTIPLE FORMS OF CYTOCHROME-P450 IN MICROSOMAL MONO-OXYGENASE SYSTEM	63	16
1700	10	3449 1977 PHYTOCHEMISTRY 16(1):69-73 BENVENISTE I; SALAUN JP; DURST F WOUNDING-INDUCED CINNAMIC ACID HYDROXYLASE IN JERUSALEM ARTICHOKE TUBER	85	16

#	Cited nodes	Nodes / Authors	GCS	LCS
1701	17	3482 1978 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 185(1):251-261 JANSSON I; SCHENKMAN JB INFLUENCES OF SUBSTRATES OF DIFFERENT MICROSOMAL ELECTRON- TRANSFER PATHWAYS ON OXIDATION-REDUCTION KINETICS OF MICROSOMAL CYTOCHROME-B5	23	16
1702	10	3484 1978 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 186(1):128-138 FANG WF; STROBEL HW DRUG AND CARCINOGEN METABOLISM SYSTEM OF RAT COLON MICROSOMES	77	16
1703	13	3496 1978 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 80(1):89-96 DICKINS M; BRIDGES JW; ELCOMBE CR; NETTER KJ NOVEL HEMOPROTEIN INDUCED BY ISOSAFROLE PRETREATMENT IN RAT	53	16
1704	15	3594 1978 EUROPEAN JOURNAL OF BIOCHEMISTRY 89(1):133-141 RAHIMTULA AD; OBRIEN PJ; SEIFRIED HE; JERINA DM MECHANISM OF ACTION OF CYTOCHROME-P-450 - OCCURRENCE OF NIH SHIFT DURING HYDROPEROXIDE-DEPENDENT AROMATIC HYDROXYLATIONS	34	16
1705	6	3630 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(13):4653-4658 ATSUTA Y; OKUDA K ISOLATION OF RAT-LIVER MITOCHONDRIAL FERREDOXIN AND ITS REDUCTASE ACTIVE IN 5 BETA-CHOLESTANE-3-ALPHA,7-ALPHA,12-ALPHA- TRIOL 26-HYDROXYLASE	37	16
1706	18	3677 1978 PHARMAZIE 33(6):325-328 REIN H; RISTAU O IMPORTANCE OF HIGH SPIN-LOW SPIN EQUILIBRIUM EXISTING IN CYTOCHROME-P-450 FOR ENZYMATIC MECHANISM	29	16
1707	3	3779 1979 BIOCHEMICAL PHARMACOLOGY 28(12):1917-1921 CHA YN; BUEDING E EFFECT OF 2(3)-TERT-BUTYL-4-HYDROXYANISOLE ADMINISTRATION ON THE ACTIVITIES OF SEVERAL HEPATIC MICROSOMAL AND CYTOPLASMIC ENZYMES IN MICE	130	16
1708	22	3833 1979 DRUG METABOLISM REVIEWS 10(2):153-185 COOPER DY; SCHLEYER H; LEVIN SS; EISENHARDT RH; NOVACK BG; ROSENTHAL O A RE-EVALUATION OF THE ROLE OF CYTOCHROME-P-450 AS THE TERMINAL OXIDASE IN HEPATIC-MICROSOMAL MIXED-FUNCTION OXIDASE CATALYZED- REACTIONS	33	16
1709	3	3848 1979 FEBS LETTERS 102(1):151-154 RICHTER C; WINTERHALTER KH; CHERRY RJ ROTATIONAL DIFFUSION OF CYTOCHROME-P-450 IN RAT-LIVER MICROSOMES	28	16
1710	69	3938 1979 PHARMACOLOGY & THERAPEUTICS 6(1):41-98 KATO R CHARACTERISTICS AND DIFFERENCES IN THE HEPATIC MIXED-FUNCTION OXIDASES OF DIFFERENT SPECIES	97	16
1711	23	4283 1981 BIOCHEMICAL PHARMACOLOGY 30(6):595-600 MORGAN ET; DEVINE M; SKETT P CHANGES IN THE RAT HEPATIC MIXED-FUNCTION OXIDASE SYSTEM ASSOCIATED WITH CHRONIC ETHANOL VAPOR INHALATION	56	16
1712	5	4398 1981 JOURNAL OF BIOLOGICAL CHEMISTRY 256(16):8287-8290 MACDONALD MJ HIGH CONTENT OF MITOCHONDRIAL GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN PANCREATIC-ISLETS AND ITS INHIBITION BY DIAZOXIDE	139	16
1713	36	4426 1981 MOLECULAR AND CELLULAR BIOCHEMISTRY 36(2):105-122 KIMURA T ACTH STIMULATION ON CHOLESTEROL SIDE-CHAIN CLEAVAGE ACTIVITY OF ADRENOCORTICAL MITOCHONDRIA - TRANSFER OF THE STIMULUS FROM PLASMA-MEMBRANE TO MITOCHONDRIA	77	16
1714	2	4501 1982 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 215(2):367-378 ROSEN GM; FINKELSTEIN E; RAUCKMAN EJ A METHOD FOR THE DETECTION OF SUPEROXIDE IN BIOLOGICAL-SYSTEMS	107	16
1715	3	4621 1982 GASTROENTEROLOGY 82(1):84-88 KNODELL RG; HOLTZMAN JL; CRANKSHAW DL; STEELE NM; STANLEY LN DRUG-METABOLISM BY RAT AND HUMAN HEPATIC MICROSOMES IN RESPONSE TO INTERACTION WITH H2-RECEPTOR ANTAGONISTS	156	16
1716	12	4670 1982 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 223(1):97-104 HAJEK KK; COOK NI; NOVAK RF MECHANISM OF INHIBITION OF MICROSOMAL DRUG-METABOLISM BY IMIDAZOLE	60	16
1717	9	4775 1983 BIOCHEMICAL JOURNAL 211(2):333-340 SHEPHARD EA; PHILLIPS IR; BAYNEY RM; PIKE SF; RABIN BR QUANTIFICATION OF NADPH - CYTOCHROME-P-450 REDUCTASE IN LIVER- MICROSOMES BY A SPECIFIC RADIOIMMUNOASSAY TECHNIQUE	29	16
1718	4	4799 1983 BIOCHEMISTRY 22(1):143-149 YUAN PM; NAKAJIN S; HANIU M; SHINODA M; HALL PF; SHIVELY JE STEROID 21-HYDROXYLASE (CYTOCHROME-P-450) FROM PORCINE ADRENOCORTICAL MICROSOMES - MICROSEQUENCE ANALYSIS OF CYSTEINE- CONTAINING PEPTIDES	59	16
1719	7	4864 1983 EUROPEAN JOURNAL OF BIOCHEMISTRY 134(2):241-248 BATTIONI P; MAHY JP; DELAFORGE M; MANSUY D REACTION OF MONOSUBSTITUTED HYDRAZINES AND DIAZENES WITH RAT- LIVER CYTOCHROME-P450 - FORMATION OF FERROUS-DIAZENE AND FERRIC SIGMA-ALKYL COMPLEXES	30	16
1720	18	5177 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(9):5776-5783 VANROLLINS M; BAKER RC; SPRECHER HW; MURPHY RC OXIDATION OF DOCOSAHEXAENOIC ACID BY RAT-LIVER MICROSOMES	53	16
1721	3	5220 1984 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81(5):1327-1331 DAHLIN DC; MIWA GT; LU AYH; NELSON SD N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN	386	16
1722	5	5224 1984 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81(10):3163-3166 TUKEY RH; LALLEY PA; NEBERT DW LOCALIZATION OF CYTOCHROME P1-450 AND P3-450 GENES TO MOUSE CHROMOSOME-9	44	16
1723	18	5317 1985 BIOCHEMISTRY 24(19):5130-5136 BACKES WL; TAMBURINI PP; JANSSON I; GIBSON GG; SLIGAR SG; SCHENKMAN JB KINETICS OF CYTOCHROME-P-450 REDUCTION - EVIDENCE FOR FASTER REDUCTION OF THE HIGH-SPIN FERRIC STATE	25	16
1724	9	5539 1986 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 246(1):19-32 WHITE RE; MCCARTHY MB ACTIVE-SITE MECHANICS OF LIVER MICROSOMAL CYTOCHROME-P-450	32	16
1725	6	5649 1986 EUROPEAN JOURNAL OF BIOCHEMISTRY 158(1):195-201 EKSTROM G; INGELMANSUNDBERG M MECHANISMS OF LIPID-PEROXIDATION DEPENDENT UPON CYTOCHROME-P- 450 LM2	41	16
1726	6	5944 1987 MOLECULAR AND CELLULAR ENDOCRINOLOGY 52(3):267-272 SIMPSON ER; EVANS CT; CORBIN CJ; POWELL FE; LEDESMA DB; MENDELSON CR SEQUENCING OF CDNA INSERTS ENCODING AROMATASE CYTOCHROME-P-450 (P-450AROM)	39	16
1727	8	6110 1988 BIOCHEMISTRY 27(5):1610-1616 ATKINS WM; SLIGAR SG DEUTERIUM-ISOTOPE EFFECTS IN NORCAMPHOR METABOLISM BY CYTOCHROME-P-450CAM - KINETIC EVIDENCE FOR THE 2-ELECTRON REDUCTION OF A HIGH-VALENT IRON OXO INTERMEDIATE	55	16
1728	9	6242 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(33):17322-17332 WOOD AW; SWINNEY DC; THOMAS PE; RYAN DE; HALL PF; LEVIN W; GARLAND WA MECHANISM OF ANDROSTENEDIONE FORMATION FROM TESTOSTERONE AND EPITESTOSTERONE CATALYZED BY PURIFIED CYTOCHROME-P-450B	29	16
1729	18	6318 1988 TOXICOLOGY 50(3):283-301 RODRIGUES AD; WADDELL PR; AHSING E; MORRIS BA; WOLF CR; IOANNIDES C INDUCTION OF THE RAT HEPATIC-MICROSOMAL MIXED-FUNCTION OXIDASES BY 3-IMIDAZOLE-CONTAINING ANTIFUNGAL AGENTS - SELECTIVITY FOR THE CYTOCHROME-P-450IIB AND CYTOCHROME-P-450III FAMILIES OF CYTOCHROMES-P-450	44	16
1730	16	6567 1989 DRUG METABOLISM REVIEWS 20(2-4):557-584 SCHENKMAN JB; THUMMEL KE; FAVREAU LV PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ALTERATIONS IN RAT HEPATIC CYTOCHROME-P-450	38	16
1731	8	6582 1989 EUROPEAN JOURNAL OF BIOCHEMISTRY 180(2):479-484 HANUKOGLU I; GUTFINGER T CDNA SEQUENCE OF ADRENODOXIN REDUCTASE - IDENTIFICATION OF NADP-BINDING SITES IN OXIDOREDUCTASES	134	16
1732	5	6676 1989 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 250(2):746-751 TINEL M; DESCATOIRE V; LARREY D; LOEPER J; LABBE G; LETTERON P; PESSAYRE D EFFECTS OF CLARITHROMYCIN ON CYTOCHROME-P-450 - COMPARISON WITH OTHER MACROLIDES	63	16
1733	9	6720 1989 MOLECULAR PHARMACOLOGY 36(5):699-707 MORGAN ET SUPPRESSION OF CONSTITUTIVE CYTOCHROME-P-450 GENE-EXPRESSION IN LIVERS OF RATS UNDERGOING AN ACUTE PHASE RESPONSE TO ENDOTOXIN	120	16
1734	17	6836 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 280(2):346-351 YOSHIDA S; HIRAI A; TAMURA Y; YOSHIDA S POSSIBLE INVOLVEMENT OF ARACHIDONIC-ACID METABOLITES OF CYTOCHROME-P450 MONOOXYGENASE PATHWAY IN VASOPRESSIN-STIMULATED GLYCOGENOLYSIS IN ISOLATED RAT HEPATOCYTES	19	16
1735	7	7360 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 285(2):231-237 TERASHIMA M; TODA K; KAWAMOTO T; KURIBAYASHI I; OGAWA Y; MAEDA T; SHIZUTA Y ISOLATION OF A FULL-LENGTH CDNA-ENCODING MOUSE AROMATASE-P450	78	16
1736	5	7388 1991 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 177(1):68-73 MIYATA M; NAGATA K; YAMAZOE Y; KATO R A GENE STRUCTURE OF TESTOSTERONE 6-BETA-HYDROXYLASE (P450IIIA)	21	16
1737	13	7398 1991 BIOCHEMICAL JOURNAL 278():749-757 EDWARDS RJ; SINGLETON AM; MURRAY BP; MURRAY S; BOOBIS AR; DAVIES DS IDENTIFICATION OF A FUNCTIONALLY CONSERVED SURFACE REGION OF RAT CYTOCHROMES-P450IA	24	16
1738	8	7422 1991 BIOCHEMICAL PHARMACOLOGY 42(6):1229-1235 MAENPAA J; SYNGELMA T; HONKAKOSKI P; LANG MA; PELKONEN O COMPARATIVE-STUDIES ON COUMARIN AND TESTOSTERONE-METABOLISM IN MOUSE AND HUMAN LIVERS - DIFFERENTIAL INHIBITIONS BY THE ANTI- P450COH ANTIBODY AND METYRAPONE	26	16
1739	8	7437 1991 BIOCHEMISTRY 30(19):4659-4662 SHIMIZU T; ITO O; HATANO M; FUJIIKURIYAMA Y CO BINDING-STUDIES OF ENGINEERED CYTOCHROME-P-450DS - EFFECTS OF MUTATIONS AT PUTATIVE DISTAL SITES IN THE PRESENCE OF POLYCYCLIC-HYDROCARBONS	30	16
1740	6	7443 1991 BIOCHEMISTRY 30(48):11430-11437 RITTER JK; OWENS IS; NEGISHI M; NAGATA K; SHEEN YY; GILLETTE JR; SASAME HA MOUSE PULMONARY CYTOCHROME-P-450 NAPHTHALENE HYDROXYLASE - CDNA CLONING, SEQUENCE, AND EXPRESSION IN SACCHAROMYCES-CEREVISIAE	34	16
1741	7	7634 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(27):17821-17825 KIKUTA Y; SOGAWA K; HANIU M; KINOSAKI M; KUSUNOSE E; NOJIMA Y; YAMAMOTO S; ICHIHARA K; KUSUNOSE M; FUJIIKURIYAMA Y A NOVEL SPECIES OF CYTOCHROME-P-450 (P-450IB) SPECIFIC FOR THE SMALL-INTESTINE OF RABBITS - CDNA CLONING AND ITS EXPRESSION IN COS CELLS	20	16
1742	14	7645 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(35):23561-23567 BALAZY M METABOLISM OF 5,6-EPOXYEICOSATRIENOIC ACID BY THE HUMAN PLATELET - FORMATION OF NOVEL THROMBOXANE ANALOGS	36	16
1743	3	7761 1991 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88(11):4731-4735 MALEE MP; MELLON SH ZONE-SPECIFIC REGULATION OF 2 MESSENGER-RNAS FOR P450C11 IN THE ADRENALS OF PREGNANT AND NONPREGNANT RATS	61	16
1744	10	7900 1992 BIOCHEMICAL JOURNAL 286():289-294 HAHNEMANN B; SALONPAA P; PASANEN M; MAENPAA J; HONKAKOSKI P; JUVONEN R; LANG MA; PELKONEN O; RAUNIO H EFFECT OF PYRAZOLE, COBALT AND PHENOBARBITAL ON MOUSE-LIVER CYTOCHROME-P-450 2A-4/5 (CYP2A-4/5) EXPRESSION	37	16
1745	9	7921 1992 BIOCHEMICAL PHARMACOLOGY 44(1):183-186 WHEELER CW; WRIGHTON SA; GUENTHNER TM DETECTION OF HUMAN LUNG CYTOCHROMES-P450 THAT ARE IMMUNOCHEMICALLY RELATED TO CYTOCHROME-P450IIE1 AND CYTOCHROME- P450IIIA	43	16
1746	9	7924 1992 BIOCHEMICAL PHARMACOLOGY 44(4):787-796 HOPKINS NE; FOROOZESH MK; ALWORTH WL SUICIDE INHIBITORS OF CYTOCHROME-P450-1A1 AND CYTOCHROME-P450- 2B1	46	16
1747	7	7963 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1131(1):23-29 KOMORI M; KIKUCHI O; KITADA M; KAMATAKI T MOLECULAR-CLONING OF MONKEY P450-1A1 CDNA AND EXPRESSION IN YEAST	24	16
1748	15	8125 1992 GASTROENTEROLOGY 103(5):1509-1516 MCDONNELL WM; SCHEIMAN JM; TRABER PG INDUCTION OF CYTOCHROME-P450IA GENES (CYP1A) BY OMEPRAZOLE IN THE HUMAN ALIMENTARY-TRACT	81	16
1749	10	8266 1992 MOLECULAR ENDOCRINOLOGY 6(10):1682-1690 MOMOI K; WATERMAN MR; SIMPSON ER; ZANGER UM 3', 5'-CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT TRANSCRIPTION OF THE CYP11A (CHOLESTEROL SIDE-CHAIN CLEAVAGE CYTOCHROME-P450) GENE INVOLVES A DNA RESPONSE ELEMENT CONTAINING A PUTATIVE BINDING-SITE FOR TRANSCRIPTION FACTOR SP1	57	16
1750	8	8351 1992 XENOBIOTICA 22(6):671-680 BERTHOU F; GUILLOIS B; RICHE C; DREANO Y; JACQZAIGRAIN E; BEAUNE PH INTERSPECIES VARIATIONS IN CAFFEINE METABOLISM RELATED TO CYTOCHROME-P4501A ENZYMES	61	16
1751	12	8369 1993 AMERICAN JOURNAL OF PHYSIOLOGY 264(4):H1154-H1160 MOFFAT MP; WARD CA; BEND JR; MOCK T; FARHANGKHOEE P; KARMAZYN M EFFECTS OF EPOXYEICOSATRIENOIC ACIDS ON ISOLATED HEARTS AND VENTRICULAR MYOCYTES	35	16
1752	41	8578 1993 CRITICAL REVIEWS IN TOXICOLOGY 23(1):1-20 RAUCY JL; KRANER JC; LASKER JM BIOACTIVATION OF HALOGENATED HYDROCARBONS BY CYTOCHROME-P4502E1	100	16
1753	13	8584 1993 DNA AND CELL BIOLOGY 12(5):371-379 HARIKRISHNA JA; BLACK SM; SZKLARZ GD; MILLER WL CONSTRUCTION AND FUNCTION OF FUSION ENZYMES OF THE HUMAN CYTOCHROME-P450SCC SYSTEM	57	16
1754	16	8622 1993 EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION 248(2):95-102 SALONPAA P; HAKKOLA J; PASANEN M; PELKONEN O; VAHAKANGAS K; BATTULA N; NOUSO K; RAUNIO H RETROVIRUS-MEDIATED STABLE EXPRESSION OF HUMAN CYP2A6 IN MAMMALIAN-CELLS	26	16
1755	14	8641 1993 GASTROENTEROLOGY 104(1):203-216 LOEPER J; DESCATOIRE V; MAURICE M; BEAUNE P; BELGHITI J; HOUSSIN D; BALLET F; FELDMANN G; GUENGERICH FP; PESSAYRE D CYTOCHROMES-P-450 IN HUMAN HEPATOCYTE PLASMA-MEMBRANE - RECOGNITION BY SEVERAL AUTOANTIBODIES	86	16
1756	13	8740 1993 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 44(1):61-67 MAENPAA J; PELKONEN O; CRESTEIL T; RANE A THE ROLE OF CYTOCHROME-P450 3A (CYP3A) ISOFORM(S) IN OXIDATIVE- METABOLISM OF TESTOSTERONE AND BENZPHETAMINE IN HUMAN ADULT AND FETAL LIVER	31	16
1757	14	8803 1993 PHARMACOGENETICS 3(5):239-249 SCHWEIKL H; TAYLOR JA; KITAREEWAN S; LINKO P; NAGORNEY D; GOLDSTEIN JA EXPRESSION OF CYP1A1 AND CYP1A2 GENES IN HUMAN LIVER	69	16
1758	10	8927 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 314(2):351-359 MIYATA M; NAGATA K; SHIMADA M; YAMAZOE Y; KATO R STRUCTURE OF A GENE AND CDNA OF A MAJOR CONSTITUTIVE FORM OF TESTOSTERONE 6-BETA-HYDROXYLASE (P450/6-BETA-A) ENCODING CYP3A2 - COMPARISON OF THE CDNA WITH P450PCN2	27	16
1759	24	8963 1994 BIOCHEMICAL PHARMACOLOGY 47(5):763-773 WEAVER RJ; THOMPSON S; SMITH G; DICKINS M; ELCOMBE CR; MAYER RT; BURKE MD A COMPARATIVE-STUDY OF CONSTITUTIVE AND INDUCED ALKOXYRESORUFIN O-DEALKYLATION AND INDIVIDUAL CYTOCHROME-P450 FORMS IN CYNOMOLGUS MONKEY (MACACA-FASCICULARIS), HUMAN, MOUSE, RAT AND HAMSTER LIVER-MICROSOMES	49	16
1760	15	9198 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(28):18378-18383 ELIASSON E; MKRTCHIAN S; HALPERT JR; INGELMANSUNDBERG M SUBSTRATE-REGULATED, CAMP-DEPENDENT PHOSPHORYLATION, DENATURATION, AND DEGRADATION OF GLUCOCORTICOID-INDUCIBLE RAT- LIVER CYTOCHROME-P450 3A1	34	16
1761	5	9245 1994 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 268(1):474-481 ZOU AP; MA YH; SUI ZH; DEMONTELLANO PRO; CLARK JE; MASTERS BS; ROMAN RJ EFFECTS OF 17-OCTADECYNOID ACID, A SUICIDE-SUBSTRATE INHIBITOR OF CYTOCHROME-P450 FATTY-ACID OMEGA-HYDROXYLASE, ON RENAL- FUNCTION IN RATS	106	16
1762	12	9457 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 322(2):369-377 HALKIER BA; NIELSEN HL; KOCH B; MOLLER BL PURIFICATION AND CHARACTERIZATION OF RECOMBINANT CYTOCHROME P450(TYR) EXPRESSED AT HIGH-LEVELS IN ESCHERICHIA-COLI	40	16
1763	25	9461 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 323(1):177-186 KOCH BM; SIBBESEN O; HALKIER BA; SVENDSEN I; MOLLER BL THE PRIMARY SEQUENCE OF CYTOCHROME P450TYR, THE MULTIFUNCTIONAL N-HYDROXYLASE CATALYZING THE CONVERSION OF L-TYROSINE TO P- HYDROXYPHENYLACETALDEHYDE OXIME IN THE BIOSYNTHESIS OF THE CYANOGENIC GLUCOSIDE DHURRIN IN SORGHUM-BICOLOR (L) MOENCH	43	16
1764	8	9507 1995 BIOCHEMISTRY 34(4):1244-1247 CAWLEY GF; BATIE CJ; BACKES WL SUBSTRATE-DEPENDENT COMPETITION OF DIFFERENT P450 ISOZYMES FOR LIMITING NADPH-CYTOCHROME P450 REDUCTASE	22	16
1765	13	9563 1995 CARCINOGENESIS 16(6):1319-1327 WALKER NJ; GASTEL JA; COSTA LT; CLARK GC; LUCIER GW; SUTTER TR RAT CYP1B1 - AN ADRENAL CYTOCHROME-P450 THAT EXHIBITS SEX- DEPENDENT EXPRESSION IN LIVERS AND KIDNEYS OF TCDD-TREATED ANIMALS	75	16
1766	18	9565 1995 CARCINOGENESIS 16(9):2167-2170 YAMAZAKI H; INUI Y; WRIGHTON SA; GUENGERICH FP; SHIMADA T PROCARCINOGEN ACTIVATION BY CYTOCHROME-P450 3A4 AND 3A5 EXPRESSED IN ESCHERICHIA-COLI AND BY HUMAN LIVER-MICROSOMES	22	16
1767	22	9569 1995 CHEMICAL RESEARCH IN TOXICOLOGY 8(1):136-142 BAUER E; GUO ZY; UENG YF; BELL LC; ZELDIN D; GUENGERICH FP OXIDATION OF BENZO[A]PYRENE BY RECOMBINANT HUMAN CYTOCHROME- P450 ENZYMES	77	16
1768	5	9778 1995 JOURNAL OF PHYSIOLOGY-LONDON 482(2):259-274 GRAIER WF; SIMECEK S; STUREK M CYTOCHROME-P450 MONO-OXYGENASE-REGULATED SIGNALING OF CA2+ ENTRY IN HUMAN AND BOVINE ENDOTHELIAL-CELLS	133	16
1769	18	9835 1995 PHARMACOGENETICS 5(1):24-36 SIDHU JS; OMIECINSKI CJ MODULATION OF XENOBIOTIC-INDUCIBLE CYTOCHROME-P450 GENE- EXPRESSION BY DEXAMETHASONE IN PRIMARY RAT HEPATOCYTES	56	16
1770	24	9985 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 335(1):219-226 Powell PK; Wolf I; Lasker JM Identification of CYP4A11 as the major lauric acid omega- hydroxylase in human liver microsomes	23	16
1771	21	10112 1996 CIRCULATION RESEARCH 79(4):784-793 Fang X; Kaduce TL; Weintraub NL; VanRollins M; Spector AA Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle	42	16
1772	16	10131 1996 CYTOCHROME P450, PT B 272():35-44 Guengerich FP; Martin MV; Guo ZY; Chun YJ Purification of functional recombinant P450s from bacteria	30	16
1773	11	10232 1996 JOURNAL OF BIOCHEMISTRY 119(5):926-933 Aoyama Y; Noshiro M; Gotoh O; Imaoka S; Funae Y; Kurosawa N; Horiuchi T; Yoshida Y Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species	47	16
1774	14	10240 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(20):12063-12067 Lee SST; Buters JTM; Pineau T; FernandezSalguero P; Gonzalez FJ Role of CYP2E1 in the hepatotoxicity of acetaminophen	108	16
1775	22	10343 1996 MOLECULAR MICROBIOLOGY 20(6):1115-1125 Munro AW; Lindsay JG Bacterial cytochromes P-450	58	16
1776	12	10440 1996 XENOBIOTICA 26(3):297-306 Lake BG; Charzat C; Tredger JM; Renwick AB; Beamand JA; Price RJ Induction of cytochrome P450 isoenzymes in cultured precision- cut rat and human liver slices	49	16
1777	19	10452 1996 XENOBIOTICA 26(11):1155-1166 Ono S; Hatanaka T; Miyazawa S; Tsutsui M; Aoyama T; Gonzalez FJ; Satoh T Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: Role of CYP2B6, 2C19 and the 3A subfamily	41	16
1778	15	10504 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 343(1):123-130 Pikuleva IA; Bjorkhem I; Waterman MR Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27)	33	16
1779	22	10515 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 347(1):148-154 Kawashima H; Kusunose E; Thompson CM; Strobel HW Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain	37	16
1780	10	10546 1997 BIOCHEMICAL JOURNAL 327():537-544 Oliver CF; Modi S; Primrose WU; Lian LY; Roberts GCK Engineering the substrate specificity of Bacillus megaterium cytochrome P-450 BM3: hydroxylation of alkyl trimethylammonium compounds	19	16
1781	25	10654 1997 DRUG METABOLISM AND DISPOSITION 25(5):617-622 Shimada T; Gillam EMJ; Sutter TR; Strickland PT; Guengerich FP; Yamazaki H Oxidation of xenobiotics by recombinant human cytochrome P450 1B1	51	16
1782	8	10860 1997 PHARMACOGENETICS 7(4):255-269 Mackenzie PI; Owens IS; Burchell B; Bock KW; Bairoch A; Belanger A; FournelGigleux S; Green M; Hum DW; Iyanagi T; Lancet D; Louisot P; Magdalou J; Chowdhury JR; Ritter JK; Schachter H; Tephly TR; Tipton KF; Nebert DW The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence	277	16
1783	10	10880 1997 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(20):10797-10802 Danielson PB; MacIntyre RJ; Fogleman JC Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome P450s: Evidence for involvement in host- plant allelochemical resistance	32	16
1784	19	10926 1997 XENOBIOTICA 27(4):319-339 Lewis DFV; Eddershaw PJ; Goldfarb PS; Tarbit MH Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: Structural studies on specific CYP2D6 substrate metabolism	49	16
1785	16	11120 1998 CIRCULATION RESEARCH 83(9):932-939 Oltman CL; Weintraub NL; VanRollins M; Dellsperger KC Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation	58	16
1786	101	11441 1998 XENOBIOTICA 28(12):1167-1202 Clarke SE In vitro assessment of human cytochrome P450	42	16
1787	88	12146 2000 JOURNAL OF LIPID RESEARCH 41(2):163-181 Capdevila JH; Falck JR; Harris RC Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase	51	16
1788	2	81 1960 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 3(4):417-422 RINGLER RL; MINAKAMI S; SINGER TP ISOLATION AND PROPERTIES OF THE DPNH DEHYDROGENASE OF THE RESPIRATORY CHAIN FROM HEART MITOCHONDRIA	51	15
1789	1	155 1962 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 8(3):180-& CHANCE B; HAGIHARA B; HOLLUNGER G INHIBITION OF ENERGY TRANSFER AT PYRIDINE NUCLEOTIDE-FLAVIN SITE	36	15
1790	9	162 1962 BIOCHEMISCHE ZEITSCHRIFT 335(5):426-& SCHOLLMEYER P; KLINGENBERG M UBER DEN CYTOCHROM-GEHALT TIERISCHER GEWEBE	97	15
1791	2	184 1962 JOURNAL OF BIOLOGICAL CHEMISTRY 237(9):2968-& MACKLER B; DUNCAN HM; RAO NA; COLLIPP PJ; HUENNEKENS FM AN ELECTRON TRANSPORT PARTICLE FROM YEAST - PURIFICATION AND PROPERTIES	101	15
1792	1	344 1964 SCIENCE 143(360):136-& CHANCE B; WILLIAMS GR; PARSONS DF CYTOCHROME CONTENT OF MITOCHONDRIA STRIPPED OF INNER MEMBRANE STRUCTURE	53	15
1793	4	489 1966 BIOCHIMICA ET BIOPHYSICA ACTA 113(1):1-& PACKER L; MUSTAFA MG PATHWAYS OF ELECTRON FLOW ESTABLISHED BY TETRAMETHYL- PHENYLENEDIAMINE IN MITOCHONDRIA AND ASCITES TUMOR CELLS	38	15
1794	7	531 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(3):624-& SACKTOR B; WORMSERS.E REGULATION OF METABOLISM IN WORKING MUSCLE IN VIVO .I. CONCENTRATIONS OF SOME GLYCOLYTIC TRICARBOXYLIC ACID CYCLE AND AMINO ACID INTERMEDIATES IN INSECT FLIGHT MUSCLE DURING FLIGHT	163	15
1795	2	544 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(22):5347-& YONETANI T; WILSON DF; SEAMONDS B STUDIES ON CYTOCHROME C PEROXIDASE .8. EFFECT OF TEMPERATURE ON LIGHT ABSORPTIONS OF ENZYME AND ITS DERIVATIVES	93	15
1796	8	561 1966 PHARMACOLOGICAL REVIEWS 18(3):1091-& KIESE M BIOCHEMICAL PRODUCTION OF FERRIHEMOGLOBIN-FORMING DERIVATIVES FROM AROMATIC AMINES AND MECHANISMS OF FERRIHEMOGLOBIN FORMATION	233	15
1797	32	580 1967 ANNUAL REVIEW OF BIOCHEMISTRY 36():539-& PULLMAN ME; SCHATZ G MITOCHONDRIAL OXIDATIONS AND ENERGY COUPLING	113	15
1798	7	656 1967 BIOCHIMICA ET BIOPHYSICA ACTA 147(3):518-& ICHIKAWA Y; YAMANO T ROLE OF HYDROPHOBIC BONDING IN P-450 AND EFFECT OF ORGANIC COMPOUNDS ON CONVERSION OF P-450 TO P-420	47	15
1799	4	783 1968 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 33(6):969-& MARVER HS; SCHMID R; SCHUTZEL H HEME AND METHEMOGLOBIN - NATURALLY OCCURRING REPRESSORS OF MICROSOMAL CYTOCHROME	78	15
1800	3	847 1968 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 349(1):85-& ULLRICH V; WOLF J; AMADORI E; STAUDING.H MIXED FUNCTION OXYGENATION OF 4-HALOGENOACETANILIDES IN RAT LIVER MICROSOMES AND MODEL SYSTEMS	45	15

#	Cited nodes	Nodes / Authors	GCS	LCS
1801	2	920 1968 LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 7(13P1):765-& BROWNIE AC; SKELTON FR; GALLANT S; NICHOLLS P; ELLIOTT WB ADRENAL CYTOCHROME LEVELS CORTICOSTEROIDOGENESIS AND RESPIRATORY ACTIVITY IN RAT FOLLOWING METHYLANDROSTENEDIOL TREATMENT	21	15
1802	6	967 1969 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 131(1):245-& PETERSON JA; MCKENNA EJ; ESTABROOK RW; COON MJ ENZYMIC OMEGA-OXIDATION - STOICHIOMETRY OF OMEGA-OXIDATION OF FATTY ACIDS	15	15
1803	6	1011 1969 BIOCHEMISTRY 8(1):322-& CRIDDLE RS; SCHATZ G PROMITOCHONDRIA OF ANAEROBICALLY GROWN YEAST .I. ISOLATION AND BIOCHEMICAL PROPERTIES	197	15
1804	4	1390 1970 NATURE 228(5273):764-& FRASER DR; KODICEK E UNIQUE BIOSYNTHESIS BY KIDNEY OF A BIOLOGICALLY ACTIVE VITAMIN- D METABOLITE	972	15
1805	11	1597 1971 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 352(8):1048-& REINER O; UEHLEKE H CARBON TETRACHLORIDE INTERACTION WITH REDUCED MICROSOMAL CYTOCHROME P-450 AND HAEM	29	15
1806	6	1609 1971 JOURNAL OF BIOCHEMISTRY 70(6):981-& MATSUBARA T; TOCHINO Y ELECTRON TRANSPORT SYSTEMS OF LUNG MICROSOMES AND THEIR PHYSIOLOGICAL FUNCTIONS .1. INTRACELLULAR DISTRIBUTION OF OXIDATIVE ENZYMES IN LUNG CELLS	42	15
1807	6	1735 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 149(2):369-& OSHINO N; SATO R DIETARY CONTROL OF MICROSOMAL STEARYL COA DESATURATION ENZYME- SYSTEM IN RAT-LIVER	192	15
1808	27	2042 1973 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 212(JUN22):156-174 LU AYH; LEVIN W; WEST S; JACOBSON M; RYAN D; KUNTZMAN R; CONNEY AH ROLE OF CYTOCHROME-P-450 AND P-448 IN DRUG AND STEROID HYDROXYLATIONS	44	15
1809	7	2047 1973 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 212(JUN22):290-306 BELL JJ; CHENG SC; HARDING BW CONTROL OF SUBSTRATE FLUX AND ADRENAL CYTOCHROME-P-450	32	15
1810	21	2065 1973 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 157(1):148-159 NEBERT DW; CONSIDIN.N; OWENS IS GENETIC EXPRESSION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION .6. CONTROL OF OTHER AROMATIC HYDROCARBON-INDUCIBLE MONO- OXYGENASE ACTIVITIES AT OR NEAR SAME GENETIC LOCUS	72	15
1811	4	2082 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 51(3):603-611 ROSEN P; STIER A KINETICS OF CO AND O2 COMPLEXES OF RABBIT LIVER MICROSOMAL CYTOCHROME P450	22	15
1812	6	2084 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 53(2):459-465 BIDLACK WR; OKITA RT; HOCHSTEI.P ROLE OF NADPH-CYTOCHROME B5 REDUCTASE IN MICROSOMAL LIPID PEROXIDATION	79	15
1813	21	2135 1973 BIOCHIMICA ET BIOPHYSICA ACTA 301(2):155-193 WIKSTROM MK DIFFERENT CYTOCHROME B COMPONENTS IN RESPIRATORY-CHAIN OF ANIMAL MITOCHONDRIA AND THEIR ROLE IN ELECTRON-TRANSPORT AND ENERGY CONSERVATION	157	15
1814	6	2171 1973 CHEMICO-BIOLOGICAL INTERACTIONS 6(3):203-205 GORROD JW; TEMPLE DJ DEMONSTRATION OF BOTH TYPE-I AND TYPE-II COMPONENTS IN DIFFERENCE SPECTRA PRODUCED BY ANILINE AND N-ETHYLANILINE WITH CYTOCHROME-P-450	17	15
1815	7	2195 1973 DRUG METABOLISM AND DISPOSITION 1(1):121-128 MASTERS BSS; NELSON EB; SCHACTER BA; BARON J; ISAACSON EL NADPH-CYTOCHROME C REDUCTASE AND ITS ROLE IN MICROSOMAL CYTOCHROME P-450-DEPENDENT REACTIONS	28	15
1816	14	2296 1973 JOURNAL OF BIOLOGICAL CHEMISTRY 248(22):7860-7864 ALFANO J; BROWNIE AC; ORMEJOHN.WH; BEINERT H ADRENAL MITOCHONDRIAL CYTOCHROME-P-450 AND CHOLESTEROL SIDE- CHAIN CLEAVAGE ACTIVITY - DIFFERENCES IN RESPONSE OF ZONA GLOMERULOSA AND ZONA FASCICULATA-RETICULARIS TO ADRENOCORTICOTROPIC HORMONE AND ITS WITHDRAWAL	35	15
1817	13	2445 1974 BIOCHEMICAL PHARMACOLOGY 23(22):3129-3138 YANG CS; STRICKHA.FS INHIBITION OF HEPATIC MIXED-FUNCTION OXIDASE ACTIVITY BY PROPYL GALLATE	61	15
1818	4	2490 1974 DRUG METABOLISM AND DISPOSITION 2(1):1-8 CHO AK; LINDEKE B; SUM CY N-HYDROXYLATION OF PHENTERMINE (2-METHYL-2-AMINO-1- PHENYLPROPANE) - PROPERTIES OF ENZYME-SYSTEM	59	15
1819	4	2587 1974 LIFE SCIENCES 15(8):1433-1442 SUGIURA M; IWASAKI K; NOGUCHI H; KATO R EVIDENCE FOR INVOLVEMENT OF CYTOCHROME-P-450 IN TIARAMIDE N- OXIDE REDUCTION	54	15
1820	8	2727 1975 BIOCHEMICAL SOCIETY TRANSACTIONS 3(6):967-970 ELCOMBE CR; BRIDGES J; NIMMOSMITH RH; WERRINGLOER J CUMENE HYDROPEROXIDE-MEDIATED FORMATION OF INHIBITED COMPLEXES OF METHYLENEDIOXYPHENYL COMPOUNDS WITH CYTOCHROME-P-450	24	15
1821	4	2795 1975 EUROPEAN JOURNAL OF BIOCHEMISTRY 51(2):329-336 DEME D; FIMIANI E; POMMIER J; NUNEZ J FREE DIIODOTYROSINE EFFECTS ON PROTEIN IODINATION AND THYROID- HORMONE SYNTHESIS CATALYZED BY THYROID PEROXIDASE	48	15
1822	7	2799 1975 EUROPEAN JOURNAL OF BIOCHEMISTRY 55(2):333-341 RICH PR; BENDALL DS CYTOCHROME COMPONENTS OF PLANT MICROSOMES	72	15
1823	5	2813 1975 FEBS LETTERS 55(1):198-201 EBEL RE; OKEEFFE DH; PETERSON JA NITRIC-OXIDE COMPLEXES OF CYTOCHROME-P-450	54	15
1824	9	2867 1975 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 193(2):621-630 CHUNG LWK; RAYMOND G; FOX S ROLE OF NEONATAL ANDROGEN IN DEVELOPMENT OF HEPATIC MICROSOMAL DRUG-METABOLIZING-ENZYMES	81	15
1825	4	2876 1975 LIFE SCIENCES 16(11):1689-1692 ZACHARIAH PK; JUCHAU MR INTERACTIONS OF STEROIDS WITH HUMAN PLACENTAL CYTOCHROME-P-450 IN PRESENCE OF CARBON-MONOXIDE	20	15
1826	11	3023 1976 BIOCHIMICA ET BIOPHYSICA ACTA 449(1):72-83 WILLIAMSSMITH DL; SIMPSON ER; BARLOW SM; MORRISON PJ ELECTRON-PARAMAGNETIC RESONANCE STUDIES OF CYTOCHROME-P-450 AND ADRENAL FERREDOXIN IN SINGLE WHOLE RAT ADRENAL-GLANDS - EFFECT OF CORTICOTROPIN	35	15
1827	7	3307 1977 BIOORGANICHESKAYA KHIMIYA 3(6):780-786 AKHREM AA; SHKUMATOV VM; CHASHCHIN VL ISOLATION OF INDIVIDUAL COMPONENTS OF STEROID-HYDROXYLATING SYSTEM FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	44	15
1828	9	3348 1977 ENDOCRINOLOGY 100(6):1610-1620 ALEXANDER NM PURIFICATION OF BOVINE THYROID PEROXIDASE	42	15
1829	45	3447 1977 PHARMACOLOGY & THERAPEUTICS PART A-CHEMOTHERAPY TOXICOLOGY AND METABOLIC INHIBITORS 1(3):327-348 BJORKHEM I RATE LIMITING STEP IN MICROSOMAL CYTOCHROME-P-450 CATALYZED HYDROXYLATIONS	30	15
1830	10	3766 1979 BIOCHEMICAL PHARMACOLOGY 28(1):97-103 FASCO MJ; PIPER LJ; KAMINSKY LS CUMENE HYDROPEROXIDE-SUPPORTED MICROSOMAL HYDROXYLATIONS OF WARFARIN - PROBE OF CYTOCHROME P-450 MULTIPLICITY AND SPECIFICITY	29	15
1831	8	3808 1979 CANCER RESEARCH 39(4):1199-1206 PROUGH RA; PATRIZI VW; OKITA RT; MASTERS BSS; JAKOBSSON SW CHARACTERISTICS OF BENZO(A)PYRENE METABOLISM BY KIDNEY, LIVER, AND LUNG MICROSOMAL FRACTIONS FROM RODENTS AND HUMANS	89	15
1832	8	3873 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(5):1726-1733 MENARD RH; GUENTHNER TM; KON H; GILLETTE JR STUDIES ON THE DESTRUCTION OF ADRENAL AND TESTICULAR CYTOCHROME-P-450 BY SPIRONOLACTONE - REQUIREMENT FOR THE 7- ALPHA-THIO GROUP AND EVIDENCE FOR THE LOSS OF THE HEME AND APOPROTEINS OF CYTOCHROME-P-450	98	15
1833	8	4142 1980 JOURNAL OF BIOLOGICAL CHEMISTRY 255(10):4667-4672 LAMBETH JD; SEYBERT DW; KAMIN H ADRENODOXIN REDUCTASE - ADRENODOXIN COMPLEX - RAPID FORMATION AND BREAKDOWN OF THE COMPLEX AND A SLOW CONFORMATIONAL CHANGE IN THE FLAVOPROTEIN	38	15
1834	14	4165 1980 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 213(1):70-78 REINKE LA; KAUFFMAN FC; BELINSKY SA; THURMAN RG INTERACTIONS BETWEEN ETHANOL-METABOLISM AND MIXED-FUNCTION OXIDATION IN PERFUSED-RAT-LIVER - INHIBITION OF PARA- NITROANISOLE O-DEMETHYLATION	63	15
1835	37	4200 1980 PHARMACOLOGY & THERAPEUTICS 9(2):227-244 MASTERS BSS; OKITA RT THE HISTORY, PROPERTIES, AND FUNCTION OF NADPH-CYTOCHROME-P-450 REDUCTASE	46	15
1836	7	4257 1981 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 210(2):505-516 JONES DP; EKLOW L; THOR H; ORRENIUS S METABOLISM OF HYDROGEN-PEROXIDE IN ISOLATED HEPATOCYTES - RELATIVE CONTRIBUTIONS OF CATALASE AND GLUTATHIONE-PEROXIDASE IN DECOMPOSITION OF ENDOGENOUSLY GENERATED H2O2	195	15
1837	5	4622 1982 GASTROENTEROLOGY 82(1):89-96 SPEEG KV; PATWARDHAN RV; AVANT GR; MITCHELL MC; SCHENKER S INHIBITION OF MICROSOMAL DRUG-METABOLISM BY HISTAMINE H2- RECEPTOR ANTAGONISTS STUDIED INVIVO AND INVITRO IN RODENTS	149	15
1838	15	4731 1982 XENOBIOTICA 12(11):717-726 GREINERT R; FINCH SAE; STIER A CYTOCHROME-P-450 ROTAMERS CONTROL MIXED-FUNCTION OXYGENATION IN RECONSTITUTED MEMBRANES - ROTATIONAL DIFFUSION STUDIED BY DELAYED FLUORESCENCE DEPOLARIZATION	36	15
1839	14	4918 1983 JOURNAL OF BIOLOGICAL CHEMISTRY 258(14):8588-8594 GUT J; RICHTER C; CHERRY RJ; WINTERHALTER KH; KAWATO S ROTATION OF CYTOCHROME-P-450 .3. COMPLEX-FORMATION OF CYTOCHROME-P-450 WITH NADPH-CYTOCHROME-P-450 REDUCTASE IN LIPOSOMES DEMONSTRATED BY COMBINING PROTEIN ROTATION WITH ANTIBODY-INDUCED CROSS-LINKING	48	15
1840	11	4962 1983 MOLECULAR AND CELLULAR ENDOCRINOLOGY 30(1):1-20 HORNSBY PJ; CRIVELLO JF THE ROLE OF LIPID-PEROXIDATION AND BIOLOGICAL ANTI-OXIDANT IN THE FUNCTION OF THE ADRENAL-CORTEX .1. A BACKGROUND REVIEW	94	15
1841	33	5247 1984 XENOBIOTICA 14(1-2):27-47 GIBSON GG; TAMBURINI PP CYTOCHROME-P-450 SPIN STATE - INORGANIC BIOCHEMISTRY OF HEME IRON LIGATION AND FUNCTIONAL-SIGNIFICANCE	34	15
1842	8	5294 1985 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 132(1):343-351 SCHWARTZMAN ML; ABRAHAM NG; MASFERRER J; DUNN MW; MCGIFF JC CYTOCHROME-P450 DEPENDENT METABOLISM OF ARACHIDONIC-ACID IN BOVINE CORNEAL EPITHELIUM	34	15
1843	8	5565 1986 BIOCHEMICAL PHARMACOLOGY 35(11):1867-1878 LAVRIJSEN K; VANHOUDT J; THIJS D; MEULDERMANS W; HEYKANTS J INDUCTION POTENTIAL OF ANTIFUNGALS CONTAINING AN IMIDAZOLE OR TRIAZOLE MOIETY - MICONAZOLE AND KETOCONAZOLE, BUT NOT ITRACONAZOLE ARE ABLE TO INDUCE HEPATIC DRUG-METABOLIZING- ENZYMES OF MALE-RATS AT HIGH-DOSES	59	15
1844	10	5621 1986 CHEMICO-BIOLOGICAL INTERACTIONS 60(1):101-114 DELAFORGE M; BATTIONI P; MAHY JP; MANSUY D INVIVO FORMATION OF JIGMA-METHYL-FERRIC AND JIGMA-PHENYL-FERRIC COMPLEXES OF HEMOGLOBIN AND LIVER-CYTOCHROME-P-450 UPON TREATMENT OF RATS WITH METHYLHYDRAZINE AND PHENYLHYDRAZINE	23	15
1845	4	5797 1987 BIOCHEMICAL PHARMACOLOGY 36(18):2921-2926 RAUCY J; FERNANDES P; BLACK M; YANG SL; KOOP DR IDENTIFICATION OF A HUMAN-LIVER CYTOCHROME-P-450 EXHIBITING CATALYTIC AND IMMUNOCHEMICAL SIMILARITIES TO CYTOCHROME-P-450- 3A OF RABBIT LIVER	38	15
1846	12	5951 1987 MOLECULAR PHARMACOLOGY 31(2):135-139 RITTER JK; FRANKLIN MR CLOTRIMAZOLE INDUCTION OF CYTOCHROME-P-450 - DOSE- DIFFERENTIATED ISOZYME INDUCTION	25	15
1847	18	6004 1987 XENOBIOTICA 17(11):1315-1327 RODRIGUES AD; LEWIS DFV; IOANNIDES C; PARKE DV SPECTRAL AND KINETIC-STUDIES OF THE INTERACTION OF IMIDAZOLE ANTIFUNGAL AGENTS WITH MICROSOMAL CYTOCHROMES-P-450	38	15
1848	4	6020 1988 ANALYTICAL BIOCHEMISTRY 169(1):71-80 WIXTROM RN; SILVA MH; HAMMOCK BD AFFINITY PURIFICATION OF CYTOSOLIC EPOXIDE HYDROLASE USING DERIVATIZED EPOXY-ACTIVATED SEPHAROSE GELS	40	15
1849	2	6079 1988 BIOCHEMICAL PHARMACOLOGY 37(10):1947-1953 FABRE G; CREVATPISANO P; DRAGNA S; COVO J; BARRA Y; CANO JP INVOLVEMENT OF THE MACROLIDE ANTIBIOTIC INDUCIBLE CYTOCHROME-P- 450 LM3C IN THE METABOLISM OF MIDAZOLAM BY MICROSOMAL FRACTIONS PREPARED FROM RABBIT LIVER	41	15
1850	17	6156 1988 CHEMICO-BIOLOGICAL INTERACTIONS 64(3):207-249 MEIJER J; DEPIERRE JW CYTOSOLIC EPOXIDE HYDROLASE	80	15
1851	28	6296 1988 PHARMACOLOGY & THERAPEUTICS 38(1):53-72 YANG CS; YOO JSH DIETARY-EFFECTS ON DRUG-METABOLISM BY THE MIXED-FUNCTION OXIDASE SYSTEM	53	15
1852	7	6461 1989 BIOCHEMISTRY 28(11):4871-4879 HULLA JE; JUCHAU MR OCCURRENCE AND INDUCIBILITY OF CYTOCHROME-P450IIIA IN MATERNAL AND FETAL RATS DURING PRENATAL DEVELOPMENT	27	15
1853	6	6486 1989 BIOCHIMICA ET BIOPHYSICA ACTA 996(1-2):142-145 OHTA K; KITADA M; HASHIZUME T; KOMORI M; OHI H; KAMATAKI T PURIFICATION OF CYTOCHROME-P-450 FROM POLYCHLORINATED BIPHENYL- TREATED CRAB-EATING MONKEYS - HIGH HOMOLOGY TO A FORM OF HUMAN CYTOCHROME-P-450	21	15
1854	7	6554 1989 DRUG METABOLISM AND DISPOSITION 17(1):26-31 HALPERT J; JAW JY; CORNFIELD LJ; BALFOUR C; MASH EA SELECTIVE INACTIVATION OF RAT-LIVER CYTOCHROMES P-450 BY 21- CHLORINATED STEROIDS	31	15
1855	9	6752 1989 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86(19):7446-7450 DEY A; WESTPHAL H; NEBERT DW CELL-SPECIFIC INDUCTION OF MOUSE CYP1A1 MESSENGER-RNA DURING DEVELOPMENT	32	15
1856	5	6898 1990 BIOCHEMICAL SOCIETY TRANSACTIONS 18(1):19-21 STEGEMAN JJ; WOODIN BR; SMOLOWITZ RM STRUCTURE, FUNCTION AND REGULATION OF CYTOCHROME-P-450 FORMS IN FISH	34	15
1857	11	6933 1990 BIOCHIMICA ET BIOPHYSICA ACTA 1036(1):18-23 IMAOKA S; YAMAGUCHI Y; FUNAE Y INDUCTION AND REGULATION OF CYTOCHROME P450.K-5 (LAURIC ACID HYDROXYLASE) IN RAT RENAL MICROSOMES BY STARVATION	31	15
1858	3	6948 1990 BIOMEDICAL CHROMATOGRAPHY 4(5):221-222 ALTERMAN MA; DOWGII AI A SIMPLE AND RAPID METHOD FOR THE PURIFICATION OF CYTOCHROME-P- 450 (FORM LM4)	22	15
1859	12	6970 1990 CANCER RESEARCH 50(18):5720-5726 LEBLANC GA; WAXMAN DJ MECHANISMS OF CYCLOPHOSPHAMIDE ACTION ON HEPATIC P-450 EXPRESSION	58	15
1860	6	7125 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(5):2903-2907 NEF P; LARABEE TM; KAGIMOTO K; MEYER UA OLFACTORY-SPECIFIC CYTOCHROME-P-450 (P-450OLF1-IIG1) - GENE STRUCTURE AND DEVELOPMENTAL REGULATION	36	15
1861	8	7136 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(17):9676-9681 FISHER JM; WU L; DENISON MS; WHITLOCK JP ORGANIZATION AND FUNCTION OF A DIOXIN-RESPONSIVE ENHANCER	75	15
1862	13	7243 1990 MOLECULAR PHARMACOLOGY 38(3):319-326 BORNHEIM LM; CORREIA MA SELECTIVE INACTIVATION OF MOUSE-LIVER CYTOCHROME-P-450IIIA BY CANNABIDIOL	36	15
1863	19	7265 1990 PHARMACOLOGY & THERAPEUTICS 47(3):419-445 BARON J; VOIGT JM LOCALIZATION, DISTRIBUTION, AND INDUCTION OF XENOBIOTIC- METABOLIZING ENZYMES AND ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY WITHIN LUNG	51	15
1864	5	7308 1990 TOXICOLOGY AND APPLIED PHARMACOLOGY 106(1):53-62 LORENZEN A; OKEY AB DETECTION AND CHARACTERIZATION OF [H-3] 2,3,7,8- TETRACHLORODIBENZO-PARA-DIOXIN BINDING TO AH RECEPTOR IN A RAINBOW-TROUT HEPATOMA-CELL LINE	76	15
1865	16	7364 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 287(1):105-111 OGURI K; KANEKO H; TANIMOTO Y; YAMADA H; YOSHIMURA H A CONSTITUTIVE FORM OF GUINEA-PIG LIVER CYTOCHROME-P450 CLOSELY RELATED TO PHENOBARBITAL INDUCIBLE P450B(E)	24	15
1866	6	7426 1991 BIOCHEMICAL PHARMACOLOGY 42(9):1841-1844 DIRVEN HAAM; PETERS JGP; GIBSON GG; PETERS WHM; JONGENEELEN FJ LAURIC ACID HYDROXYLASE-ACTIVITY AND CYTOCHROME-P450 IV FAMILY PROTEINS IN HUMAN LIVER-MICROSOMES	23	15
1867	12	7454 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1088(2):319-322 CIACCIO PJ; GRAVES PE; BOURQUE DP; GLINSMANNGIBSON B; HALPERT JR CDNA AND DEDUCED AMINO-ACID-SEQUENCES OF A DOG LIVER CYTOCHROME-P-450 OF THE IIIA GENE SUBFAMILY	30	15
1868	3	7473 1991 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 31(6):689-692 WARD SA; HELSBY NA; SKJELBO E; BROSEN K; GRAM LF; BRECKENRIDGE AM THE ACTIVATION OF THE BIGUANIDE ANTIMALARIAL PROGUANIL CO- SEGREGATES WITH THE MEPHENYTOIN OXIDATION POLYMORPHISM - A PANEL STUDY	107	15
1869	13	7524 1991 DNA AND CELL BIOLOGY 10(4):271-282 OHKUMA M; TANIMOTO T; YANO K; TAKAGI M CYP52 (CYTOCHROME-P450ALK) MULTIGENE FAMILY IN CANDIDA-MALTOSA - MOLECULAR-CLONING AND NUCLEOTIDE-SEQUENCE OF THE 2 TANDEMLY ARRANGED GENES	32	15
1870	21	7595 1991 INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 72(3):349-363 PAINE AJ THE CYTOCHROME-P450 GENE SUPERFAMILY	29	15
1871	6	7627 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(17):11199-11204 KAGAWA N; WATERMAN MR EVIDENCE THAT AN ADRENAL-SPECIFIC NUCLEAR-PROTEIN REGULATES THE CAMP RESPONSIVENESS OF THE HUMAN CYP21B (P450C21) GENE	43	15
1872	7	7655 1991 JOURNAL OF CLINICAL INVESTIGATION 88(4):1370-1378 MANNS MP; GRIFFIN KJ; SULLIVAN KF; JOHNSON EF LKM-1 AUTOANTIBODIES RECOGNIZE A SHORT LINEAR SEQUENCE IN P450IID6, A CYTOCHROME-P-450 MONOOXYGENASE	225	15
1873	4	7706 1991 METHODS IN ENZYMOLOGY 206():220-233 EDWARDS RJ; MURRAY BP; BOOBIS AR ANTIPEPTIDE ANTIBODIES IN STUDIES OF CYTOCHROMES-P450IA	30	15
1874	17	7749 1991 PHARMACOLOGY & THERAPEUTICS 49(1-2):21-42 WHITE RE THE INVOLVEMENT OF FREE-RADICALS IN THE MECHANISMS OF MONOOXYGENASES	46	15
1875	17	7788 1991 TOXICOLOGY AND APPLIED PHARMACOLOGY 108(3):436-447 RAMSDELL HS; PARKINSON A; EDDY AC; EATON DL BIOACTIVATION OF AFLATOXIN-B1 BY HUMAN LIVER-MICROSOMES - ROLE OF CYTOCHROME-P450 IIIA ENZYMES	46	15
1876	12	7849 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 292(1):136-140 KITAMURA R; SATO K; SAWADA M; ITOH S; KITADA M; KOMORI M; KAMATAKI T STABLE EXPRESSION OF CYTOCHROME-P450IIIA7 CDNA IN HUMAN BREAST- CANCER CELL-LINE MCF-7 AND ITS APPLICATION TO CYTOTOXICITY TESTING	27	15
1877	9	7852 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 293(1):9-16 TIERNEY DJ; HAAS AL; KOOP DR DEGRADATION OF CYTOCHROME-P450 2E1 - SELECTIVE LOSS AFTER LABILIZATION OF THE ENZYME	87	15
1878	15	7939 1992 BIOCHEMISTRY 31(30):6911-6916 TUCK SF; DEMONTELLANO PRO TOPOLOGICAL MAPPING OF THE ACTIVE-SITES OF CYTOCHROME-P4502B1 AND CYTOCHROME-P4502B2 BY INSITU REARRANGEMENT OF ARYL-IRON COMPLEXES	25	15
1879	8	7971 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1160(3):281-286 VIJAYAKUMAR S; SALERNO JC MOLECULAR MODELING OF THE 3-D STRUCTURE OF CYTOCHROME P-450SCC	35	15
1880	10	8001 1992 CARCINOGENESIS 13(6):979-985 YAMAZAKI H; ODA Y; FUNAE Y; IMAOKA S; INUI Y; GUENGERICH FP; SHIMADA T PARTICIPATION OF RAT-LIVER CYTOCHROME P450-2E1 IN THE ACTIVATION OF N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE TO PRODUCTS GENOTOXIC IN AN ACETYLTRANSFERASE-OVEREXPRESSING SALMONELLA-TYPHIMURIUM STRAIN (NM2009)	53	15
1881	8	8097 1992 FASEB JOURNAL 6(2):667-668 GUENGERICH FP CYTOCHROME-P450 - ADVANCES AND PROSPECTS	35	15
1882	18	8177 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(24):17333-17338 VENEPALLY P; CHEN D; KEMPER B TRANSCRIPTIONAL REGULATORY ELEMENTS FOR BASAL EXPRESSION OF CYTOCHROME P450IIC GENES	30	15
1883	5	8633 1993 FOOD AND CHEMICAL TOXICOLOGY 31(5):377-& LAKE BG; BEAMAND JA; JAPENGA AC; RENWICK A; DAVIES S; PRICE RJ INDUCTION OF CYTOCHROME-P-450-DEPENDENT ENZYME-ACTIVITIES IN CULTURED RAT-LIVER SLICES	56	15
1884	11	8638 1993 FUNDAMENTAL AND APPLIED TOXICOLOGY 20(1):72-82 HAASCH ML; QUARDOKUS EM; SUTHERLAND LA; GOODRICH MS; LECH JJ HEPATIC CYP1A1 INDUCTION IN RAINBOW-TROUT BY CONTINUOUS FLOWTHROUGH EXPOSURE TO BETA-NAPHTHOFLAVONE	66	15
1885	10	8674 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(1):269-275 TUCK SF; GRAHAMLORENCE S; PETERSON JA; DEMONTELLANO PRO ACTIVE-SITES OF THE CYTOCHROME-P450(CAM) (CYP101) F87W AND F87A MUTANTS - EVIDENCE FOR SIGNIFICANT STRUCTURAL REORGANIZATION WITHOUT ALTERATION OF CATALYTIC REGIOSPECIFICITY	24	15
1886	12	8681 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(10):7553-7561 KLEIN ML; FULCO AJ CRITICAL RESIDUES INVOLVED IN FMN BINDING AND CATALYTIC ACTIVITY IN CYTOCHROME-P450(BM-3)	25	15
1887	7	8699 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(29):21722-21726 RAMSDEN R; SOMMER KM; OMIECINSKI CJ PHENOBARBITAL INDUCTION AND TISSUE-SPECIFIC EXPRESSION OF THE RAT CYP2B2 GENE IN TRANSGENIC MICE	71	15
1888	12	8718 1993 JOURNAL OF LIPID MEDIATORS 6(1-3):199-208 WONG PYK; LIN KT; YAN YT; AHERN D; ILES J; SHEN SY; BHATT RK; FALCK JR 14(R),15(S)-EPOXYEICOSATRIENOIC ACID (14(R),15(S)-EET) RECEPTOR IN GUINEA-PIG MONONUCLEAR CELL-MEMBRANES	26	15
1889	24	8809 1993 PHARMACOLOGY & THERAPEUTICS 57(2-3):237-257 MARTUCCI CP; FISHMAN J P450 ENZYMES OF ESTROGEN METABOLISM	162	15
1890	7	8871 1993 TRENDS IN PHARMACOLOGICAL SCIENCES 14(8):292-294 BIRKETT DJ; MACKENZIE PI; VERONESE ME; MINERS JO IN-VITRO APPROACHES CAN PREDICT HUMAN DRUG-METABOLISM	63	15
1891	10	8931 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 315(2):454-459 DING XX; COON MJ STEROID-METABOLISM BY RABBIT OLFACTORY-SPECIFIC P450 2G1	25	15
1892	14	8958 1994 BIOCHEMICAL JOURNAL 301():753-758 RAM PA; WAXMAN DJ DEHYDROEPIANDROSTERONE 3-BETA-SULFATE IS AN ENDOGENOUS ACTIVATOR OF THE PEROXISOME-PROLIFERATION PATHWAY - INDUCTION OF CYTOCHROME-P-450 4A AND ACYL-COA OXIDASE MESSENGER-RNAS IN PRIMARY RAT HEPATOCYTE CULTURE AND INHIBITORY EFFECTS OF CA2+- CHANNEL BLOCKERS	25	15
1893	22	9013 1994 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1206(1):42-48 LAETHEM RM; HALPERT JR; KOOP DR EPOXIDATION OF ARACHIDONIC-ACID AS AN ACTIVE-SITE PROBE OF CYTOCHROME-P-450 2B ISOFORMS	24	15
1894	19	9110 1994 EUROPEAN JOURNAL OF BIOCHEMISTRY 222(3):843-850 URBAN P; WERCKREICHHART D; TEUTSCH HG; DURST F; REGNIER S; KAZMAIER M; POMPON D CHARACTERIZATION OF RECOMBINANT PLANT CINNAMATE 4-HYDROXYLASE PRODUCED IN YEAST - KINETIC AND SPECTRAL PROPERTIES OF THE MAJOR PLANT P450 OF THE PHENYLPROPANOID PATHWAY	61	15
1895	5	9218 1994 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 78(2):428-432 BULUN SE; SIMPSON ER COMPETITIVE REVERSE TRANSCRIPTION-POLYMERASE CHAIN-REACTION ANALYSIS INDICATES THAT LEVELS OF AROMATASE CYTOCHROME-P450 TRANSCRIPTS IN ADIPOSE-TISSUE OF BUTTOCKS, THIGHS, AND ABDOMEN OF WOMEN INCREASE WITH ADVANCING AGE	60	15
1896	15	9299 1994 MOLECULAR PHARMACOLOGY 45(2):352-358 RELLING MV; NEMEC J; SCHUETZ EG; SCHUETZ JD; GONZALEZ FJ; KORZEKWA KR O-DEMETHYLATION OF EPIPODOPHYLLOTOXINS IS CATALYZED BY HUMAN CYTOCHROME-P450 3A4	81	15
1897	22	9371 1994 TOXICOLOGY AND APPLIED PHARMACOLOGY 127(2):187-198 HAHN ME; STEGEMAN JJ REGULATION OF CYTOCHROME P4501A1 IN TELEOSTS - SUSTAINED INDUCTION OF CYP1A1 MESSENGER-RNA, PROTEIN, AND CATALYTIC ACTIVITY BY 2,3,7,8-TETRACHLORODIBENZOFURAN IN THE MARINE FISH STENOTOMUS CHRYSOPS	50	15
1898	7	9454 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 322(1):204-213 ROY NK; KREAMER GL; KONKLE B; GRUNWALD C; WIRGIN I CHARACTERIZATION AND PREVALENCE OF A POLYMORPHISM IN THE 3'- UNTRANSLATED REGION OF CYTOCHROME P4501A1 IN CANCER-PRONE ATLANTIC TOMCOD	29	15
1899	4	9652 1995 EPILEPSIA 36():S8-S13 LEVY RH CYTOCHROME-P450 ISOZYMES AND ANTIEPILEPTIC DRUG-INTERACTIONS	67	15
1900	14	9814 1995 MOLECULAR ENDOCRINOLOGY 9(3):340-349 ZHAO Y; MENDELSON CR; SIMPSON ER CHARACTERIZATION OF THE SEQUENCES OF THE HUMAN CYP19 (AROMATASE) GENE THAT MEDIATE REGULATION BY GLUCOCORTICOIDS IN ADIPOSE STROMAL CELLS AND FETAL HEPATOCYTES	57	15

#	Cited nodes	Nodes / Authors	GCS	LCS
1901	27	10001 1996 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 221(1):157-162 Wang HM; Kawashima H; Strobel HW cDNA cloning of a novel CYP3A from rat brain	32	15
1902	28	10168 1996 ENDOCRINE REVIEWS 17(3):221-244 Stocco DM; Clark BJ Regulation of the acute production of steroids in steroidogenic cells	316	15
1903	19	10315 1996 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 277(2):768-774 Nunoya KI; Yokoi T; Kimura K; Kodama T; Funayama M; Inoue K; Nagashima K; Funae Y; Shimada N; Green C; Kamataki T (+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes	34	15
1904	15	10356 1996 MOLECULAR PHARMACOLOGY 50(4):781-788 Liu C; Zhuo XL; Gonzalez FJ; Ding XX Baculovirus-Mediated expression and characterization of rat CYP2A3 and human CYP2A6: Role in metabolic activation of nasal toxicants	38	15
1905	22	10597 1997 CANCER RESEARCH 57(10):1946-1954 Chang TKH; Yu L; Maurel P; Waxman DJ Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines	77	15
1906	25	10658 1997 DRUG METABOLISM AND DISPOSITION 25(8):985-993 Code EL; Crespi CL; Penman BW; Gonzalez FJ; Chang TKH; Waxman DJ Human cytochrome P4502B6 - Interindividual hepatic expression, substrate specificity, and role in procarcinogen activation	69	15
1907	6	10666 1997 DRUG METABOLISM AND DISPOSITION 25(11):1298-1303 Shet MS; Mcphaul M; Fisher CW; Stallings NR; Estabrook RW Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2	15	15
1908	11	10924 1997 XENOBIOTICA 27(2):175-187 Gooneratne R; Miranda CL; Henderson MC; Buhler DR beta-Naphthoflavone induced CYP1A1 and 1A3 proteins in the liver of rainbow trout (Oncorhynchus mykiss)	19	15
1909	47	10958 1998 ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY 49():311-343 Chapple C Molecular-genetic analysis of plant cytochrome P450-dependent monooxygenases	79	15
1910	11	11097 1998 CANCER RESEARCH 58(9):1833-1838 Suzuki A; Kushida H; Iwata H; Watanabe M; Nohmi T; Fujita K; Gonzalez FJ; Kamataki T Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines	31	15
1911	32	11304 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 285(3):1327-1336 Powell PK; Wolf I; Jin RY; Lasker JM Metabolism of arachidonic acid to 20-hydroxy-5,8,11,14- eicosatetraenoic acid by P450 enzymes in human liver: Involvement of CYP4F2 and CYP4A11	33	15
1912	8	12239 2000 SCIENCE 287(5458):1615-1622 Schlichting I; Berendzen J; Chu K; Stock AM; Maves SA; Benson DE; Sweet BM; Ringe D; Petsko GA; Sligar SG The catalytic pathway of cytochrome P450cam at atomic resolution	193	15
1913	6	43 1959 ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY 21():73-129 GREEN DE ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION	101	14
1914	4	54 1959 BIOCHEMISCHE ZEITSCHRIFT 331(4):334-336 KLINGENBERG M; SLENCZKA W ATMUNGSAKTIVITAT VON MITOCHONDRIEN VERSCHIEDENER ORGANE MIT GLYCERIN-1-P IM VERGLEICH ZU SUBSTRATEN DES TRICARBONSAURECYCLUS	29	14
1915	2	129 1961 JOURNAL OF BIOLOGICAL CHEMISTRY 236(4):1192-& RINGLER RL STUDIES ON MITOCHONDRIAL ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE .2. EXTRACTION AND PARTIAL PURIFICATION OF DEHYDROGENASE FROM PIG BRAIN	47	14
1916	1	186 1962 JOURNAL OF CELL BIOLOGY 13(2):345-& LINNANE AW; VITOLS E; NOWLAND PG STUDIES ON ORIGIN OF YEAST MITOCHONDRIA	149	14
1917	2	220 1963 BIOCHIMICA ET BIOPHYSICA ACTA 77(3):419-& HOWLAND JL PHOSPHORYLATION COUPLED TO OXIDATION OF TETRAMETHYL-RHO- PHENYLENEDIAMINE IN RAT-LIVER MITOCHONDRIA	48	14
1918	3	253 1963 PLANT PHYSIOLOGY 38(5):594-& WISKICH JT; BONNER WD PREPARATION AND PROPERTIES OF SWEET POTATO MITOCHONDRIA	143	14
1919	4	594 1967 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 121(3):757-& WILSON DF EFFECT OF TEMPERATURE ON SPECTRAL PROPERTIES OF SOME FERROCYTOCHROMES	64	14
1920	14	747 1968 ANNUAL REVIEW OF BIOCHEMISTRY 37():249-& SCRUTTON MC; UTTER MF REGULATION OF GLYCOLYSIS AND GLUCONEOGENESIS IN ANIMAL TISSUES	638	14
1921	1	851 1968 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 349(11):1605-& ESTABROOK RW; HILDEBRANDT A; ULLRICH V OXYGEN INTERACTION WITH REDUCED CYTOCHROME P-450	13	14
1922	11	870 1968 JOURNAL OF BIOCHEMISTRY 63(3):370-& IMAI Y; SATO R BEHAVIOR OF 2 STATES OF ETHYL ISOCYANIDE COMPOUND OF REDUCED P- 450 IN OXIDATION-REDUCTION CYCLE	17	14
1923	8	1006 1969 BIOCHEMICAL PHARMACOLOGY 18(6):1501-& HLAVICA P; KIESE M N-OXYGENATION OF N-ALKYL- AND N,N-DIALKYLANILINES BY RABBIT LIVER MICROSOMES	37	14
1924	5	1160 1969 PLANT PHYSIOLOGY 44(1):126-& STOREY BT; BAHR JT RESPIRATORY CHAIN OF PLANT MITOCHONDRIA .2. OXIDATIVE PHOSPHORYLATION IN SKUNK CABBAGE MITOCHONDRIA	69	14
1925	4	1315 1970 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 351(8):913-& FROMMER U; ULLRICH V; STAUDING.H HYDROXYLATION OF ALIPHATIC COMPOUNDS BY LIVER MICROSOMES .2. EFFECT OF PHENOBARBITAL INDUCTION IN RATS ON SPECIFIC ACTIVITY AND CYTOCHROME P-450 SUBSTRATE BINDING SPECTRA	26	14
1926	8	1353 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(15):3882-& MCKENNA EJ; COON MJ ENZYMATIC OMEGA-OXIDATION .4. PURIFICATION AND PROPERTIES OF OMEGA-HYDROXYLASE OF PSEUDOMONAS-OLEOVORANS	119	14
1927	9	1521 1971 BIOCHEMISTRY 10(15):2916-& UZGIRIS VI; MCINTOSH EN; ALONSO C; SALHANIC.HA ROLE OF REVERSED ELECTRON TRANSPORT IN BOVINE CORPUS LUTEUM MITOCHONDRIAL STEROID SYNTHESIS	27	14
1928	13	1847 1972 BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 8(3):186-& MAILMAN RB; HODGSON E CYTOCHROME-P-450 SUBSTRATE OPTICAL DIFFERENCE SPECTRA OF PESTICIDES WITH MOUSE HEPATIC MICROSOMES	18	14
1929	11	1933 1972 JOURNAL OF BIOLOGICAL CHEMISTRY 247(16):5010-& UEDA T; COON MJ ENZYMATIC OMEGA-OXIDATION .7. REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE-RUBREDOXIN REDUCTASE - PROPERTIES AND FUNCTION AS AN ELECTRON CARRIER IN OMEGA HYDROXYLATION	55	14
1930	2	2014 1972 TOXICOLOGY AND APPLIED PHARMACOLOGY 22(1):50-& CHHABRA RS; FOUTS JR; GRAM TE COMPARATIVE STUDY OF 2 PROCEDURES USED IN DETERMINATION OF HEPATIC MICROSOMAL ANILINE HYDROXYLATION	59	14
1931	13	2019 1972 XENOBIOTICA 2(3):259-& VAINIO H; HANNINEN O ENHANCEMENT OF ANILINE PARA HYDROXYLATION BY ACETONE IN RAT- LIVER MICROSOMES	39	14
1932	5	2021 1972 XENOBIOTICA 2(6):517-527 FRANKLIN MR PIPERONYL BUTOXIDE METABOLISM BY CYTOCHROME-P-450 - FACTORS AFFECTING FORMATION AND DISAPPEARANCE OF METABOLITE CYTOCHROME P-450 COMPLEX	19	14
1933	11	2216 1973 DRUG METABOLISM AND DISPOSITION 1(6):766-774 JACOBSON M; LEVIN W; LU AYH; CONNEY AH; KUNTZMAN R RATE OF PENTOBARBITAL AND ACETANILIDE METABOLISM BY LIVER- MICROSOMES - FUNCTION OF LIPID PEROXIDATION AND DEGRADATION OF CYTOCHROME-P-450 HEME	62	14
1934	12	2505 1974 DRUG METABOLISM AND DISPOSITION 2(6):577-582 THOMPSON JA; HOLTZMAN JL DEUTERIUM AND TRITIUM ISOTOPE-EFFECTS ON MICROSOMAL N- DEMETHYLATION OF ETHYLMORPHINE	35	14
1935	21	2535 1974 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 355(11):1341-1349 MANSUY D; DUPPEL W; RUF HH; ULLRICH V PHOSPHINES AS LIGANDS TO MICROSOMAL CYTOCHROME-P-450	32	14
1936	5	2564 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(23):7529-7535 HENRY HL; NORMAN AW STUDIES ON CALCIFEROL METABOLISM .9. RENAL "25-HYDROXY-VITAMIN- D3-1-HYDROXYLASE - INVOLVEMENT OF CYTOCHROME-P-450 AND OTHER PROPERTIES	138	14
1937	6	2596 1974 MOLECULAR PHARMACOLOGY 10(6):1004-1008 JEFFERY E; MANNERIN.GJ DISCREPANCY IN MEASUREMENT OF REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDE OXIDIZED DURING ETHYLMORPHINE N-DEMETHYLATION DUE TO PRESENCE OF A NUCLEOTIDE PYROPHOSPHATASE	25	14
1938	7	2618 1974 STEROIDS 23(2):185-201 BRYAN GT; LEWIS AM; HARKINS JB; MICHELET.SF; BOYD GS CYTOCHROME +450 AND STEROID 21-HYDROXYLATION IN MICROSOMES FROM BEEF ADRENAL-CORTEX	20	14
1939	6	2797 1975 EUROPEAN JOURNAL OF BIOCHEMISTRY 54(1):11-18 HOUSTEK J; CANNON B; LINDBERG O GLYCEROL-3-PHOSPHATE SHUTTLE AND ITS FUNCTION IN INTERMEDIARY METABOLISM OF HAMSTER BROWN-ADIPOSE TISSUE	42	14
1940	19	2883 1975 MOLECULAR AND CELLULAR BIOCHEMISTRY 8(2):69-79 ELLIN A; ORRENIUS S FATTY-ACID HYDROXYLATION IN RAT-KIDNEY CORTEX MICROSOMES	48	14
1941	19	2885 1975 MOLECULAR PHARMACOLOGY 11(2):201-210 KAWALEK JC; LU AYH RECONSTITUTED LIVER MICROSOMAL-ENZYME SYSTEM THAT HYDROXYLATES DRUGS, OTHER FOREIGN COMPOUNDS, AND ENDOGENOUS SUBSTRATES .8. DIFFERENT CATALYTIC ACTIVITIES OF RABBIT AND RAT CYTOCHROMES P- 448	38	14
1942	4	3011 1976 BIOCHEMISTRY 15(14):3091-3097 HIWATASHI A; ICHIKAWA Y; YAMANO T; MARUYA N PROPERTIES OF CRYSTALLINE REDUCED NICOTINAMIDE ADENINE- DINUCLEOTIDE PHOSPHATE-ADRENODOXIN REDUCTASE FROM BOVINE ADRENOCORTICAL MITOCHONDRIA .2. ESSENTIAL HISTIDYL AND CYSTEINYL RESIDUES AT NADPH BINDING-SITE OF NADPH-ADRENODOXIN REDUCTASE	34	14
1943	2	3096 1976 FEBS LETTERS 64(2):332-337 RICHTER C; AZZI A; WENDEL A EFFECT OF A TYROSINE-DIVALENT COPPER COMPLEX ON HEPATIC MICROSOMAL DEMETHYLATION	26	14
1944	5	3162 1976 LIFE SCIENCES 18(3):279-290 HOOK GER; BEND JR PULMONARY METABOLISM OF XENOBIOTICS	93	14
1945	13	3265 1977 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 78(4):1139-1146 PIERSON WC; CINTI DL TEMPERATURE-DEPENDENT AND TEMPERATURE-INDUCED SPECTRAL CHARACTERISTICS AND TRANSITIONS OF LIVER-MICROSOMES	20	14
1946	8	3439 1977 MOLECULAR PHARMACOLOGY 13(4):759-765 KRASNY HC; HOLBROOK DJ EFFECTS OF CADMIUM ON MICROSOMAL HEMOPROTEINS AND HEME OXYGENASE IN RAT-LIVER	72	14
1947	8	3512 1978 BIOCHEMICAL PHARMACOLOGY 27(1):61-69 MALEJKAGIGANTI D; MCIVER RC; GLASEBROOK AL; GUTMANN HR INDUCTION OF MICROSOMAL N-HYDROXYLATION OF N-2- FLUORENYLACETAMIDE IN RAT-LIVER	55	14
1948	7	3572 1978 CIRCULATION RESEARCH 43(3):429-437 SYLVESTER JT; MCGOWAN C EFFECTS OF AGENTS THAT BIND TO CYTOCHROME-P-450 ON HYPOXIC PULMONARY VASOCONSTRICTION	55	14
1949	8	3684 1978 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75(12):5955-5959 TSONG TY; YANG CS RAPID CONFORMATIONAL-CHANGES OF CYTOCHROME-P-450 - EFFECT OF DIMYRISTOYL LECITHIN	27	14
1950	11	3886 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(14):6464-6469 PEDERSEN JI; BJORKHEM I; GUSTAFSSON J 26-HYDROXYLATION OF C27-STEROIDS BY SOLUBLE LIVER MITOCHONDRIAL CYTOCHROME-P-450	79	14
1951	1	3927 1979 MOLECULAR PHARMACOLOGY 16(2):676-685 FINKELSTEIN E; ROSEN GM; RAUCKMAN EJ; PAXTON J SPIN TRAPPING OF SUPEROXIDE	267	14
1952	12	3960 1979 TOXICOLOGY AND APPLIED PHARMACOLOGY 48(2):293-304 MEANS JR; CARLSON GP; SCHNELL RC STUDIES ON THE MECHANISM OF CADMIUM-INDUCED INHIBITION OF THE HEPATIC MICROSOMAL MONO-OXYGENASE OF THE MALE-RAT	64	14
1953	14	4026 1980 BIOCHEMICAL PHARMACOLOGY 29(4):553-558 STEGEMAN JJ; CHEVION M SEX-DIFFERENCES IN CYTOCHROME-P-450 AND MIXED-FUNCTION OXYGENASE ACTIVITY IN GONADALLY MATURE TROUT	98	14
1954	5	4270 1981 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 99(2):682-690 MORGENSTERN R; DEPIERRE JW; LIND C; GUTHENBERG C; MANNERVIK B; ERNSTER L BENZO(ALPHA)PYRENE QUINONES CAN BE GENERATED BY LIPID- PEROXIDATION AND ARE CONJUGATED WITH GLUTATHIONE BY GLUTATHIONE S-TRANSFERASE-B FROM RAT-LIVER	66	14
1955	5	4296 1981 BIOCHEMICAL PHARMACOLOGY 30(14):2033-2036 ULLRICH V; CASTLE L; WEBER P SPECTRAL EVIDENCE FOR THE CYTOCHROME-P450 NATURE OF PROSTACYCLIN SYNTHETASE	55	14
1956	14	4389 1981 JOURNAL OF BIOLOGICAL CHEMISTRY 256(9):4329-4335 HANUKOGLU I; PRIVALLE CT; JEFCOATE CR MECHANISMS OF IONIC ACTIVATION OF ADRENAL MITOCHONDRIAL CYTOCHROME-P-450SCC AND CYTOCHROME-P450(11-BETA)	46	14
1957	9	4411 1981 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 218(2):509-514 DANAN G; DESCATOIRE V; PESSAYRE D SELF-INDUCTION BY ERYTHROMYCIN OF ITS OWN TRANSFORMATION INTO A METABOLITE FORMING AN INACTIVE COMPLEX WITH REDUCED CYTOCHROME- P-450	101	14
1958	13	4532 1982 BIOCHEMICAL PHARMACOLOGY 31(3):391-396 NASTAINCZYK W; AHR HJ; ULLRICH V THE REDUCTIVE METABOLISM OF HALOGENATED ALKANES BY LIVER MICROSOMAL CYTOCHROME-P450	89	14
1959	3	5047 1984 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 123(2):581-588 BEDNAR MM; SCHWARTZMAN M; IBRAHAM NG; MCGIFF JC; MULLANE KM CONVERSION OF ARACHIDONIC-ACID TO 2 NOVEL PRODUCTS BY A CYTOCHROME-P450-DEPENDENT MIXED-FUNCTION OXIDASE IN POLYMORPHONUCLEAR LEUKOCYTES	29	14
1960	7	5077 1984 BIOCHIMICA ET BIOPHYSICA ACTA 793(3):408-415 OLIW EH METABOLISM OF 5(6)-EXPOXYEICOSATRIENOIC ACID BY RAM SEMINAL- VESICLES - FORMATION OF NOVEL PROSTAGLANDIN-E1 METABOLITES	26	14
1961	14	5358 1985 CHEMICO-BIOLOGICAL INTERACTIONS 54(2):127-141 SCHWARZE W; BLANCK J; RISTAU O; JANIG GR; POMMERENING K; REIN H; RUCKPAUL K SPIN STATE CONTROL OF CYTOCHROME-P-450 REDUCTION AND CATALYTIC ACTIVITY IN A RECONSTITUTED-P-450 LM2 SYSTEM AS INDUCED BY A SERIES OF BENZPHETAMINE ANALOGS	21	14
1962	3	5394 1985 FEDERATION PROCEEDINGS 44(1):19-24 JOHNSON AR; REVTYAK G; CAMPBELL WB ARACHIDONIC-ACID METABOLITES AND ENDOTHELIAL INJURY - STUDIES WITH CULTURES OF HUMAN-ENDOTHELIAL CELLS	87	14
1963	6	5440 1985 JOURNAL OF BIOLOGICAL CHEMISTRY 260(16):9150-9153 WONG PYK; MALIK KU; TAYLOR BM; SCHNEIDER WP; MCGIFF JC; SUN FF EPOXIDATION OF PROSTACYCLIN IN THE RABBIT KIDNEY	16	14
1964	39	5504 1985 VITAMINS AND HORMONES-ADVANCES IN RESEARCH AND APPLICATIONS 42():315-368 HALL PF ROLE OF CYTOCHROMES-P-450 IN THE BIOSYNTHESIS OF STEROID- HORMONES	41	14
1965	10	5678 1986 JOURNAL OF BIOLOGICAL CHEMISTRY 261(3):1083-1087 LARROQUE C; VANLIER JE HYDROPEROXYSTEROLS AS A PROBE FOR THE MECHANISM OF CYTOCHROME P-450SCC-MEDIATED HYDROXYLATION - HOMOLYTIC VERSUS HETEROLYTIC OXYGEN-OXYGEN BOND SCISSION	24	14
1966	3	5785 1987 BIOCHEMICAL JOURNAL 248(1):301-304 BARNES TS; SHAW PM; BURKE MD; MELVIN WT MONOCLONAL-ANTIBODIES AGAINST HUMAN CYTOCHROME-P-450 RECOGNIZING DIFFERENT PREGNENOLONE 16-ALPHA-CARBONITRILE- INDUCIBLE RAT CYTOCHROMES-P-450	28	14
1967	3	5942 1987 MOLECULAR AND CELLULAR ENDOCRINOLOGY 50(3):263-268 JOHN ME; SIMPSON ER; CARR BR; MAGNESS RR; ROSENFELD CR; WATERMAN MR; MASON JI ONTOGENY OF ADRENAL-STEROID HYDROXYLASES - EVIDENCE FOR CAMP- INDEPENDENT GENE-EXPRESSION	42	14
1968	9	6012 1988 AMERICAN JOURNAL OF PHYSIOLOGY 255(1):F151-F157 CARROLL MA; SCHWARTZMAN M; BABA M; MILLER MJS; MCGIFF JC RENAL CYTOCHROME-P-450-RELATED ARACHIDONATE METABOLISM IN RABBIT AORTIC COARCTATION	39	14
1969	4	6028 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 260(2):638-644 KUTTY RK; DANIEL RF; RYAN DE; LEVIN W; MAINES MD RAT-LIVER CYTOCHROME P-450B, P-420B, AND P-420C ARE DEGRADED TO BILIVERDIN BY HEME OXYGENASE	61	14
1970	8	6293 1988 PHARMACEUTICAL RESEARCH 5(2):67-75 POULOS TL CYTOCHROME-P450 - MOLECULAR ARCHITECTURE, MECHANISM, AND PROSPECTS FOR RATIONAL INHIBITOR DESIGN	29	14
1971	14	6311 1988 PROGRESS IN LIPID RESEARCH 27(4):271-323 SPECTOR AA; GORDON JA; MOORE SA HYDROXYEICOSATETRAENOIC ACIDS (HETES)	270	14
1972	2	6472 1989 BIOCHEMISTRY INTERNATIONAL 18(2):429-438 OHGIYA S; KOMORI M; FUJITANI T; MIURA T; SHINRIKI N; KAMATAKI T CLONING OF HUMAN CYTOCHROME-P-450 CDNA AND ITS EXPRESSION IN SACCHAROMYCES-CEREVISIAE	17	14
1973	3	6690 1989 MARINE ENVIRONMENTAL RESEARCH 28(1-4):25-30 ELSKUS AA; STEGEMAN JJ; SUSANI LC; BLACK D; PRUELL RJ; FLUCK SJ POLYCHLORINATED-BIPHENYLS CONCENTRATION AND CYTOCHROME-P-450E EXPRESSION IN WINTER FLOUNDER FROM CONTAMINATED ENVIRONMENTS	31	14
1974	5	6742 1989 PHARMACOLOGY & THERAPEUTICS 41(1-2):243-256 DEVEREUX TR; DOMIN BA; PHILPOT RM XENOBIOTIC METABOLISM BY ISOLATED PULMONARY CELLS	76	14
1975	7	6769 1989 TOXICOLOGY AND APPLIED PHARMACOLOGY 98(2):278-288 KOOP DR; LAETHEM CL; SCHNIER GG IDENTIFICATION OF ETHANOL-INDUCIBLE P450 ISOZYME-3A (P450IIE1) AS A BENZENE AND PHENOL HYDROXYLASE	111	14
1976	15	6862 1990 BIOCHEMICAL JOURNAL 265(1):187-194 WAXMAN DJ; LAPENSON DP; NAGATA K; CONLON HD PARTICIPATION OF 2 STRUCTURALLY RELATED ENZYMES IN RAT HEPATIC- MICROSOMAL ANDROSTENEDIONE 7-ALPHA-HYDROXYLATION	29	14
1977	5	6874 1990 BIOCHEMICAL PHARMACOLOGY 39(3):471-476 WATKINS PB; MURRAY SA; THOMAS PE; WRIGHTON SA DISTRIBUTION OF CYTOCHROMES-P-450, CYTOCHROME-B5, AND NADPH- CYTOCHROME-P-450 REDUCTASE IN AN ENTIRE HUMAN LIVER	29	14
1978	8	6875 1990 BIOCHEMICAL PHARMACOLOGY 39(3):489-498 SESARDIC D; EDWARDS RJ; DAVIES DS; THOMAS PE; LEVIN W; BOOBIS AR HIGH-AFFINITY PHENACETIN O-DEETHYLASE IS CATALYZED SPECIFICALLY BY CYTOCHROME-P450D (P450IA2) IN THE LIVER OF THE RAT	48	14
1979	8	7012 1990 DNA AND CELL BIOLOGY 9(1):49-56 ZAPHIROPOULOS PG; WESTIN S; STROM A; MODE A; GUSTAFSSON JA STRUCTURAL AND REGULATORY ANALYSIS OF A CYTOCHROME-P450 GENE (CYP2C12) EXPRESSED PREDOMINANTLY IN FEMALE RAT-LIVER	27	14
1980	7	7117 1990 JOURNAL OF BIOCHEMISTRY 108(4):522-524 IMAI Y; UNO T; NAKAMURA M CHARACTERIZATION OF RABBIT LIVER P450IIE1 SYNTHESIZED IN TRANSFORMED YEAST-CELLS	15	14
1981	11	7147 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(31):19223-19229 RAM PA; WAXMAN DJ PRETRANSLATIONAL CONTROL BY THYROID-HORMONE OF RAT-LIVER STEROID 5-ALPHA-REDUCTASE AND COMPARISON TO THE THYROID DEPENDENCE OF 2 GROWTH HORMONE-REGULATED CYP2C MESSENGER-RNAS	47	14
1982	14	7153 1990 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 16(3):438-443 ESCALANTE B; SESSA WC; FALCK JR; YADAGIRI P; SCHWARTZMAN ML CYTOCHROME-P450-DEPENDENT ARACHIDONIC-ACID METABOLITES, 19- HYDROXYEICOSATETRAENOIC AND 20-HYDROXYEICOSATETRAENOIC ACIDS, ENHANCE SODIUM-POTASSIUM ATPASE ACTIVITY IN VASCULAR SMOOTH- MUSCLE	19	14
1983	9	7161 1990 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 70(5):1325-1329 YANASE T; SANDERS D; SHIBATA A; MATSUI N; SIMPSON ER; WATERMAN MR COMBINED 17-ALPHA-HYDROXYLASE 17,20-LYASE DEFICIENCY DUE TO A 7-BASEPAIR DUPLICATION IN THE N-TERMINAL REGION OF THE CYTOCHROME-P45017-ALPHA (CYP17) GENE	40	14
1984	7	7248 1990 MOLECULAR PHARMACOLOGY 38(5):644-651 UCHIDA T; KOMORI M; KITADA M; KAMATAKI T ISOLATION OF CDNAS CODING FOR 3 DIFFERENT FORMS OF LIVER MICROSOMAL CYTOCHROME-P-450 FROM POLYCHLORINATED BIPHENYL- TREATED BEAGLE DOGS	27	14
1985	26	7331 1991 ADVANCES IN APPLIED MICROBIOLOGY 36():133-178 SARIASLANI FS MICROBIAL CYTOCHROMES-P-450 AND XENOBIOTIC METABOLISM	60	14
1986	12	7460 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1097(3):187-192 IMAOKA S; FUJITA S; FUNAE Y AGE-DEPENDENT EXPRESSION OF CYTOCHROME-P-450S IN RAT-LIVER	54	14
1987	6	7474 1991 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 32(3):295-302 LADONA MG; LINDSTROM B; THYR C; PENG DR; RANE A DIFFERENTIAL FETAL DEVELOPMENT OF THE O-DEMETHYLATION AND N- DEMETHYLATION OF CODEINE AND DEXTROMETHORPHAN IN MAN	48	14
1988	3	7526 1991 DNA AND CELL BIOLOGY 10(5):397-398 NEBERT DW CORRECTION	20	14
1989	8	7552 1991 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 10(6):765-774 MONOSSON E; STEGEMAN JJ CYTOCHROME P450E (P450IA) INDUCTION AND INHIBITION IN WINTER FLOUNDER BY 3,3',4,4'-TETRACHLOROBIPHENYL - COMPARISON OF RESPONSE IN FISH FROM GEORGES BANK AND NARRAGANSETT BAY	52	14
1990	5	7609 1991 JOURNAL OF BIOCHEMISTRY 110(2):232-236 KUBOTA M; SOGAWA K; KAIZU Y; SAWAYA T; WATANABE J; KAWAJIRI K; GOTOH O; FUJIIKURIYAMA Y XENOBIOTIC RESPONSIVE ELEMENT IN THE 5'-UPSTREAM REGION OF THE HUMAN P-450C GENE	33	14
1991	17	7620 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(10):6291-6301 KUHNVELTEN WN; BUNSE T; FORSTER MEC ENZYME KINETIC AND INHIBITION ANALYSES OF CYTOCHROME-P450XVII, A PROTEIN WITH A BIFUNCTIONAL CATALYTIC SITE - QUANTIFICATION OF EFFECTIVE SUBSTRATE CONCENTRATIONS AT THE ACTIVE-SITE AND THEIR SIGNIFICANCE FOR INTRINSIC CONTROL OF THE HYDROXYLASE LYASE REACTION SEQUENCE	33	14
1992	7	7649 1991 JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS 562(1-2):237-247 CLARE RA; HUANG S; DOIG MV; GIBSON GG GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC CHARACTERIZATION OF SOME NOVEL HYDROXYEICOSATETRAENOIC ACIDS FORMED ON INCUBATION OF ARACHIDONIC-ACID WITH MICROSOMES FROM INDUCED RAT LIVERS	17	14
1993	1	7654 1991 JOURNAL OF CLINICAL INVESTIGATION 88(4):1197-1206 HALLER RG; HENRIKSSON KG; JORFELDT L; HULTMAN E; WIBOM R; SAHLIN K; ARESKOG NH; GUNDER M; AYYAD K; BLOMQVIST CG; HALL RE; THUILLIER P; KENNAWAY NG; LEWIS SF DEFICIENCY OF SKELETAL-MUSCLE SUCCINATE-DEHYDROGENASE AND ACONITASE - PATHOPHYSIOLOGY OF EXERCISE IN A NOVEL HUMAN MUSCLE OXIDATIVE DEFECT	36	14
1994	10	7671 1991 JOURNAL OF NUTRITION 121(7):959-965 YOO JSH; NING SM; PANTUCK CB; PANTUCK EJ; YANG CS REGULATION OF HEPATIC-MICROSOMAL CYTOCHROME-P450IIE1 LEVEL BY DIETARY LIPIDS AND CARBOHYDRATES IN RATS	68	14
1995	21	7855 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 293(2):231-240 EYER CS; BACKES WL RELATIONSHIP BETWEEN THE RATE OF REDUCTASE - CYTOCHROME P450 COMPLEX-FORMATION AND THE RATE OF 1ST ELECTRON-TRANSFER	19	14
1996	17	7934 1992 BIOCHEMISTRY 31(10):2835-2841 CHRISTOU M; MITCHELL MJ; AOYAMA T; GELBOIN HV; GONZALEZ FJ; JEFCOATE CR SELECTIVE SUPPRESSION OF THE CATALYTIC ACTIVITY OF CDNA- EXPRESSED CYTOCHROME-P4502B1 TOWARD POLYCYCLIC-HYDROCARBONS IN THE MICROSOMAL MEMBRANE - MODIFICATION OF THIS EFFECT BY SPECIFIC AMINO-ACID SUBSTITUTIONS	23	14
1997	6	8076 1992 EUROPEAN JOURNAL OF BIOCHEMISTRY 204(1):407-412 BUHLER R; LINDROS KO; NORDLING A; JOHANSSON I; INGELMANSUNDBERG M ZONATION OF CYTOCHROME-P450 ISOZYME EXPRESSION AND INDUCTION IN RAT-LIVER	54	14
1998	8	8103 1992 FASEB JOURNAL 6(2):719-723 ZANGER UM; KAGAWA N; LUND J; WATERMAN MR DISTINCT BIOCHEMICAL-MECHANISMS FOR CAMP-DEPENDENT TRANSCRIPTION OF CYP17 AND CYP21	27	14
1999	8	8150 1992 JOURNAL OF BIOCHEMISTRY 112(2):249-252 TEUNISSEN Y; GERAERTS WPM; VANHEERIKHUIZEN H; PLANTA RJ; JOOSSE J MOLECULAR-CLONING OF A CDNA-ENCODING A MEMBER OF A NOVEL CYTOCHROME P450 FAMILY IN THE MOLLUSK LYMNAEA-STAGNALIS	20	14
2000	9	8171 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(18):12583-12591 VERGERES G; WASKELL L EXPRESSION OF CYTOCHROME-B(5) IN YEAST AND CHARACTERIZATION OF MUTANTS OF THE MEMBRANE-ANCHORING DOMAIN	35	14

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