#	Cited nodes	Nodes / Authors	GCS	LCS
1101	2	87 1960 BIOCHEMICAL PHARMACOLOGY 3(4):289-296 TAPPEL AL INHIBITION OF ELECTRON TRANSPORT BY ANTIMYCIN-A, ALKYL HYDROXY NAPTHOQUINONES AND METAL COORDINATION COMPOUNDS	109	23
1102	6	161 1962 BIOCHEMICAL JOURNAL 82(2):362-& VANDENBERGH SG; SLATER EC RESPIRATORY ACTIVITY AND PERMEABILITY OF HOUSEFLY SARCOSOMES	112	23
1103	4	398 1965 BIOCHIMICA ET BIOPHYSICA ACTA 110(3):475-& BURGOS J; REDFEARN ER INHIBITION OF MITOCHONDRIAL REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE OXIDATION BY TORENOIDS	86	23
1104	8	567 1966 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 55(4):888-& PYE K; CHANCE B SUSTAINED SINUSOIDAL OSCILLATIONS OF REDUCED PYRIDINE NUCLEOTIDE IN A CELL-FREE EXTRACT OF SACCHAROMYCES CARLSBERGENSIS	82	23
1105	3	919 1968 LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 7(3P1):129-& CASTRO JA; SASAME HA; SUSSMAN H; GILLETTE JR DIVERSE EFFECTS OF SKF 525-A AND ANTIOXIDANTS ON CARBON TETRACHLORIDE-INDUCED CHANGES IN LIVER MICROSOMAL P-450 CONTENT AND ETHYLMORPHINE METABOLISM	138	23
1106	11	1056 1969 CLINICAL PHARMACOLOGY & THERAPEUTICS 10(5):655-& ALVARES AP; SCHILLIN.G; LEVIN W; KUNTZMAN R; BRAND L; MARK LC CYTOCHROMES P-450 AND B5 IN HUMAN LIVER MICROSOMES	70	23
1107	4	1136 1969 LABORATORY INVESTIGATION 20(5):455-& HUTTERER F; KLION FM; WENGRAF A; SCHAFFNE.F; POPPER H HEPATOCELLULAR ADAPTATION AND INJURY - STRUCTURAL AND BIOCHEMICAL CHANGES FOLLOWING DIELDRIN AND METHYL BUTTER YELLOW	121	23
1108	17	1186 1970 AMERICAN JOURNAL OF MEDICINE 49(5):617-& REMMER H ROLE OF LIVER IN DRUG METABOLISM	195	23
1109	2	1529 1971 BIOCHIMICA ET BIOPHYSICA ACTA 235(1):44-& DANNER DJ; MORRISON M ISOLATION OF THYROID PEROXIDASE COMPLEX	32	23
1110	7	1610 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(1):83-& MEIGS RA; RYAN KJ ENZYMATIC AROMATIZATION OF STEROIDS .1. EFFECTS OF OXYGEN AND CARBON MONOXIDE ON INTERMEDIATE STEPS OF ESTROGEN BIOSYNTHESIS	84	23
1111	5	1751 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 152(1):136-& FRENKEL R ISOLATION AND SOME PROPERTIES OF A CYTOSOL AND A MITOCHONDRIAL MALIC ENZYME FROM BOVINE BRAIN	44	23
1112	6	1961 1972 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 183(3):489-498 MACLEOD SM; RENTON KW; EADE NR DEVELOPMENT OF HEPATIC MICROSOMAL DRUG-OXIDIZING ENZYMES IN IMMATURE MALE AND FEMALE RATS	88	23
1113	14	1975 1972 MOLECULAR PHARMACOLOGY 8(2):204-& PHILPOT RM; HODGSON E EFFECT OF PIPERONYL BUTOXIDE CONCENTRATION ON FORMATION OF CYTOCHROME-P-450 DIFFERENCE SPECTRA IN HEPATIC MICROSOMES FROM MICE	53	23
1114	21	1980 1972 MOLECULAR PHARMACOLOGY 8(6):651-& NEBERT DW; GIELEN JE; GOUJON FM GENETIC EXPRESSION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION .3. CHANGES IN BINDING OF N-OCTYLAMINE TO CYTOCHROME-P-450	72	23
1115	8	2006 1972 SCIENCE 178(4061):576-& CONNEY AH; BURNS JJ METABOLIC INTERACTIONS AMONG ENVIRONMENTAL CHEMICALS AND DRUGS	246	23
1116	5	2165 1973 CANCER RESEARCH 33(11):2983-2986 CZYGAN P; GREIM H; GARRO AJ; HUTTERER F; SCHAFFNE.F; POPPER H; ROSENTHA.O; COOPER DY MICROSOMAL METABOLISM OF DIMETHYLNITROSAMINE AND CYTOCHROME-P- 450 DEPENDENCY OF ITS ACTIVATION TO A MUTAGEN	232	23
1117	10	2556 1974 JOURNAL OF BIOLOGICAL CHEMISTRY 249(12):3867-3875 LIN RC; DAVIS EJ MALIC ENZYMES OF RABBIT HEART-MITOCHONDRIA - SEPARATION AND COMPARISON OF SOME CHARACTERISTICS OF A NICOTINAMIDE ADENINE DINUCLEOTIDE-PREFERRING AND A NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE-SPECIFIC ENZYME	103	23
1118	13	2771 1975 CHEMICO-BIOLOGICAL INTERACTIONS 10(3):215-228 MAILMAN RB; TATE LG; MUSE KE; COONS LB; HODGSON E OCCURRENCE OF MULTIPLE FORMS OF CYTOCHROME-P-450 IN HEPATIC MICROSOMES FROM UNTREATED RATS AND MICE	35	23
1119	10	2937 1976 ACTA PHARMACEUTICA SUECICA 13(4):313-320 JONSSON J; LINDEKE B FORMATION OF CYTOCHROME-P-450 PRODUCT COMPLEXES DURING METABOLISM OF PHENYLALKYLAMINES	58	23
1120	5	2990 1976 BIOCHEMICAL PHARMACOLOGY 25(2):109-113 STIER A LIPID STRUCTURE AND DRUG-METABOLIZING ENZYMES	49	23
1121	9	2994 1976 BIOCHEMICAL PHARMACOLOGY 25(5):609-612 MANSUY D; BEAUNE P; CHOTTARD JC; BARTOLI JF; GANS P NATURE OF 455NM ABSORBING COMPLEX FORMED DURING CYTOCHROME P450 DEPENDENT OXIDATIVE-METABOLISM OF AMPHETAMINE	58	23
1122	9	3445 1977 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 7(4):349-354 MAYER RT; JERMYN JW; BURKE MD; PROUGH RA METHOXYRESORUFIN AS A SUBSTRATE FOR FLUOROMETRIC ASSAY OF INSECT MICROSOMAL O-DEALKYLASES	98	23
1123	6	3535 1978 BIOCHEMISTRY 17(11):2206-2211 GRIFFIN BW; TING PL MECHANISM OF N-DEMETHYLATION OF AMINOPYRINE BY HYDROGEN- PEROXIDE CATALYZED BY HORSERADISH-PEROXIDASE, METMYOGLOBIN, AND PROTOHEMIN	114	23
1124	24	3884 1979 JOURNAL OF BIOLOGICAL CHEMISTRY 254(13):5641-5646 WOOD AW GENETIC-REGULATION OF COUMARIN HYDROXYLASE-ACTIVITY IN MICE - BIOCHEMICAL CHARACTERIZATION OF THE ENZYME FROM 2 INBRED STRAINS AND THEIR F1-HYBRID	52	23
1125	18	3975 1979 XENOBIOTICA 9(9):555-564 RENDIC S; SUNJIC V; TOSO R; KAJFEZ F; RUF HH INTERACTION OF CIMETIDINE WITH LIVER-MICROSOMES	207	23
1126	6	4252 1981 ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 251(1):26-38 NIEMEGEERS CJE; LEVRON JC; AWOUTERS F; JANSSEN PAJ INHIBITION AND INDUCTION OF MICROSOMAL-ENZYMES IN THE RAT - A COMPARATIVE-STUDY OF 4 ANTI-MYCOTICS - MICONAZOLE, ECONAZOLE, CLOTRIMAZOLE AND KETOCONAZOLE	86	23
1127	20	4487 1982 ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE 21():1-52 NEBERT DW; NEGISHI M; LANG MA; HJELMELAND LM; EISEN HJ THE AH LOCUS, A MULTIGENE FAMILY NECESSARY FOR SURVIVAL IN A CHEMICALLY ADVERSE ENVIRONMENT - COMPARISON WITH THE IMMUNE- SYSTEM	110	23
1128	19	5813 1987 BIOCHEMISTRY 26(20):6429-6435 POMPON D RABBIT LIVER CYTOCHROME-P-450 LM2 - ROLES OF SUBSTRATES, INHIBITORS, AND CYTOCHROME-B5 IN MODULATING THE PARTITION BETWEEN PRODUCTIVE AND ABORTIVE MECHANISMS	36	23
1129	44	5883 1987 DRUG METABOLISM REVIEWS 18(1):55-81 MURRAY M MECHANISMS OF THE INHIBITION OF CYTOCHROME-P-450-MEDIATED DRUG OXIDATION BY THERAPEUTIC AGENTS	72	23
1130	16	6370 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 268(2):617-629 DUTTON DR; PARKINSON A REDUCTION OF 7-ALKOXYRESORUFINS BY NADPH-CYTOCHROME-P450 REDUCTASE AND ITS DIFFERENTIAL-EFFECTS ON THEIR O-DEALKYLATION BY RAT-LIVER MICROSOMAL CYTOCHROME-P450	61	23
1131	1	6436 1989 BIOCHEMICAL PHARMACOLOGY 38(9):1535-1538 PETERS WHM; KREMERS PG CYTOCHROMES-P-450 IN THE INTESTINAL-MUCOSA OF MAN	60	23
1132	9	6650 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(32):18960-18965 MCCLELLANGREEN PD; LINKO P; YEOWELL HN; GOLDSTEIN JA HORMONAL-REGULATION OF MALE-SPECIFIC RAT HEPATIC CYTOCHROME P- 450G (P-450IIC13) BY ANDROGENS AND THE PITUITARY	42	23
1133	5	6966 1990 CANCER RESEARCH 50(7):2060-2063 AOYAMA T; GELBOIN HV; GONZALEZ FJ MUTAGENIC ACTIVATION OF 2-AMINO-O-METHYLIMIDAZO[4,5-F]QUINOLINE BY COMPLEMENTARY DNA-EXPRESSED HUMAN LIVER P-450	64	23
1134	2	7105 1990 JOURNAL OF BACTERIOLOGY 172(6):3335-3345 OMER CA; LENSTRA R; LITLE PJ; DEAN C; TEPPERMAN JM; LETO KJ; ROMESSER JA; OKEEFE DP GENES FOR 2 HERBICIDE-INDUCIBLE CYTOCHROMES-P-450 FROM STREPTOMYCES-GRISEOLUS	64	23
1135	7	7532 1991 DRUG METABOLISM AND DISPOSITION 19(1):113-123 SMOLOWITZ RM; HAHN ME; STEGEMAN JJ IMMUNOHISTOCHEMICAL LOCALIZATION OF CYTOCHROME-P-450LA1 INDUCED BY 3,3',4,4'-TETRACHLOROBIPHENYL AND BY 2,3,7,8- TETRACHLORODIBENZOAFURAN IN LIVER AND EXTRAHEPATIC TISSUES OF THE TELEOST STENOTOMUS-CHRYSOPS (SCUP)	94	23
1136	24	7664 1991 JOURNAL OF MEDICINAL CHEMISTRY 34(6):1838-1844 GUENGERICH FP; BRIAN WR; IWASAKI M; SARI MA; BAARNHIELM C; BERNTSSON P OXIDATION OF DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKERS AND ANALOGS BY HUMAN LIVER CYTOCHROME-P-450 IIIA4	126	23
1137	15	7882 1992 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 298(2):715-725 TELHADA MB; PEREIRA TM; LECHNER MC EFFECT OF DEXAMETHASONE AND PHENOBARBITAL ON RUN-ON TRANSCRIPTION RATE AND CYP3A MESSENGER-RNA CONCENTRATION IN RAT-LIVER - CHANGES DURING DEVELOPMENT	41	23
1138	9	7973 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1171(2):141-146 KOMORI M; KIKUCHI O; SAKUMA T; FUNAKI J; KITADA M; KAMATAKI T MOLECULAR-CLONING OF MONKEY LIVER CYTOCHROME-P-450 CDNAS - SIMILARITY OF THE PRIMARY SEQUENCES TO HUMAN CYTOCHROMES-P-450	35	23
1139	9	8043 1992 DNA AND CELL BIOLOGY 11(5):397-404 GANDHI R; VARAK E; GOLDBERG ML MOLECULAR ANALYSIS OF A CYTOCHROME-P450 GENE OF FAMILY-4 ON THE DROSOPHILA X-CHROMOSOME	37	23
1140	5	8310 1992 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89(4):1458-1462 KAWAMOTO T; MITSUUCHI Y; TODA K; YOKOYAMA Y; MIYAHARA K; MIURA S; OHNISHI T; ICHIKAWA Y; NAKAO K; IMURA H; ULICK S; SHIZUTA Y ROLE OF STEROID 11-BETA-HYDROXYLASE AND STEROID 18-HYDROXYLASE IN THE BIOSYNTHESIS OF GLUCOCORTICOIDS AND MINERALOCORTICOIDS IN HUMANS	104	23
1141	11	8398 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 301(1):103-113 SIDHU JS; FARIN FM; OMIECINSKI CJ INFLUENCE OF EXTRACELLULAR-MATRIX OVERLAY ON PHENOBARBITAL- MEDIATED INDUCTION OF CYP2B1, 2B2, AND 3A1-GENES IN PRIMARY ADULT-RAT HEPATOCYTE CULTURE	76	23
1142	9	8543 1993 CANCER RESEARCH 53(21):5121-5126 ZHOUPAN XR; SEREE E; ZHOU XJ; PLACIDI M; MAUREL P; BARRA Y; RAHMANI R INVOLVEMENT OF HUMAN LIVER CYTOCHROME-P450-3A IN VINBLASTINE METABOLISM - DRUG-INTERACTIONS	77	23
1143	52	8599 1993 DRUG METABOLISM REVIEWS 25(3):325-387 KOYMANS L; DENKELDER GMDO; TE JMK; VERMEULEN NPE CYTOCHROMES-P450 - THEIR ACTIVE-SITE STRUCTURE AND MECHANISM OF OXIDATION	37	23
1144	19	8712 1993 JOURNAL OF CLINICAL INVESTIGATION 92(2):1018-1024 SCHUETZ JD; KAUMA S; GUZELIAN PS IDENTIFICATION OF THE FETAL LIVER CYTOCHROME-CYP3A7 IN HUMAN ENDOMETRIUM AND PLACENTA	48	23
1145	17	8928 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 314(2):367-375 JOHN GH; HASLER JA; HE YA; HALPERT JR ESCHERICHIA-COLI EXPRESSION AND CHARACTERIZATION OF CYTOCHROMES P450 2B11, 2B1, AND 2B5	49	23
1146	11	8951 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 203(2):1168-1174 AMET Y; BERTHOU F; GOASDUFF T; SALAUN JP; LEBRETON L; MENEZ JF EVIDENCE THAT CYTOCHROME-P450 2E1 IS INVOLVED IN THE (OMEGA-1)- HYDROXYLATION OF LAURIC ACID IN RAT-LIVER MICROSOMES	49	23
1147	11	9137 1994 FEBS LETTERS 348(1):70-74 KIKUTA Y; KUSUNOSE E; KONDO T; YAMAMOTO S; KINOSHITA H; KUSUNOSE M CLONING AND EXPRESSION OF A NOVEL FORM OF LEUKOTRIENE B-4 OMEGA-HYDROXYLASE FROM HUMAN LIVER	45	23
1148	19	9305 1994 MOLECULAR PHARMACOLOGY 46(2):338-345 HASLER JA; HARLOW GR; SZKLARZ GD; JOHN GH; KEDZIE KM; BURNETT VL; HE YA; KAMINSKY LS; HALPERT JR SITE-DIRECTED MUTAGENESIS OF PUTATIVE SUBSTRATE RECOGNITION SITES IN CYTOCHROME-P450-2B11 - IMPORTANCE OF AMINO-ACID RESIDUE-114, RESIDUE-290, AND RESIDUE-363 FOR SUBSTRATE- SPECIFICITY	46	23
1149	63	9414 1995 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 35():29-53 HALPERT JR STRUCTURAL BASIS OF SELECTIVE CYTOCHROME-P450 INHIBITION	61	23
1150	11	10191 1996 FASEB JOURNAL 10(2):202-204 Estabrook RW The remarkable P4150s: A historical overview of these versatile hemeprotein catalysts	23	23
1151	23	10195 1996 FASEB JOURNAL 10(10):1112-1117 Gonzalez FJ; Lee YH Cytochromes P450 .6. Constitutive expression of hepatic cytochrome P450 genes	49	23
1152	26	10598 1997 CANCER RESEARCH 57(14):3026-3031 Murray GI; Taylor MC; McFadyen MCE; McKay JA; Greenlee WF; Burke MD; Melvin WT Tumor-specific expression of cytochrome P450 CYP1B1	87	23
1153	41	11028 1998 BIOCHEMICAL PHARMACOLOGY 55(8):1315-1325 Iwata H; Fujita K; Kushida H; Suzuki A; Konno Y; Nakamura K; Fujino A; Kamataki T High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli	39	23
1154	27	11840 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(5):1863-1868 Sevrioukova IF; Li HY; Zhang H; Peterson JA; Poulos TL Structure of a cytochrome P450-redox partner electron-transfer complex	73	23
1155	4	22 1958 ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY 20():147-199 SLATER EC THE CONSTITUTION OF THE RESPIRATORY CHAIN IN ANIMAL TISSUES	104	22
1156	5	53 1959 BIOCHEMISCHE ZEITSCHRIFT 331(4):312-333 KLINGENBERG M; BUCHER T FLUGMUSKELMITOCHONDRIEN AUS LOCUSTA MIGRATORIA MIT ATMUNGSKONTROLLE - AUFBAU UND ZUSAMMENSETZUNG DER ATMUNGSKETTE	83	22
1157	2	340 1964 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 52(2):337-& CHANCE B; SCHOENER B; ELSAESSE.S CONTROL OF WAVEFORM OF OSCILLATIONS OF REDUCED PYRIDINE NUCLEOTIDE LEVEL IN CELL-FREE EXTRACT	47	22
1158	5	501 1966 BULLETIN DE LA SOCIETE DE CHIMIE BIOLOGIQUE 48(11):1189-& OHNISHI T; SOTTOCAS.G; ERNSTER L CURRENT APPROACHES TO MECHANISM OF ENERGY-COUPLING IN RESPIRATORY CHAIN . STUDIES WITH YEAST MITOCHONDRIA	86	22
1159	2	627 1967 BIOCHEMICAL PHARMACOLOGY 16(10):2030-& MCLEAN AEM EFFECT OF HEXANE AND CARBON TETRACHLORIDE ON MICROSOMAL CYTOCHROME (P450)	51	22
1160	7	862 1968 JAPANESE JOURNAL OF PHARMACOLOGY 18(4):482-& KATO R; TAKANAKA A; TAKAYANA.M STUDIES ON MECHANISM OF SEX DIFFERENCE IN DRUG-OXIDIZING ACTIVITY OF LIVER MICROSOMES	45	22
1161	8	882 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(4):834-& HORGAN DJ; SINGER TP; CASIDA JE STUDIES ON RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE	160	22
1162	10	934 1968 PLANT PHYSIOLOGY 43(5):756-& LANCE C; BONNER WD RESPIRATORY CHAIN COMPONENTS OF HIGHER PLANT MITOCHONDRIA	121	22
1163	8	1053 1969 CANCER RESEARCH 29(10):1763-& NEBERT DW; WINKER J; GELBOIN HV ARYL HYDROCARBON HYDROXYLASE ACTIVITY IN HUMAN PLACENTA FROM CIGARETTE SMOKING AND NONSMOKING WOMEN	190	22
1164	14	1067 1969 EUROPEAN JOURNAL OF BIOCHEMISTRY 9(3):415-& ORRENIUS S; THOR H FATTY ACID INTERACTION WITH HYDROXYLATING ENZYME SYSTEM OF RAT LIVER MICROSOMES	38	22
1165	10	1147 1969 MOLECULAR PHARMACOLOGY 5(5):499-& LEVIN W; KUNTZMAN R BIPHASIC DECREASE OF RADIOACTIVE HEMOPROTEIN FROM LIVER MICROSOMAL CARBON MONOXIDE-BINDING PARTICLES - EFFECT OF PHENOBARBITAL AND CHLORDANE	40	22
1166	6	1358 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(23):6373-& NEBERT DW; BAUSSERM.LL GENETIC DIFFERENCES IN EXTENT OF ARYL HYDROCARBON HYDROXYLASE INDUCTION IN MOUSE FETAL CELL CULTURES	86	22
1167	4	1468 1971 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 43(4):747-& ISAKA S; HALL PF SOLUBLE CYTOCHROME P.450 FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	26	22
1168	9	1749 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 151(2):427-& PETERSON JA; GRIFFIN BW CARBON-MONOXIDE BINDING BY PSEUDOMONAS-PUTIDA CYTOCHROME-P-450	65	22
1169	24	1759 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 153(2):543-553 LEVIN W; LU AYH; RYAN D; WEST S; KUNTZMAN R; CONNEY AH PARTIAL-PURIFICATION AND PROPERTIES OF CYTOCHROMES P-450 AND P- 448 FROM RAT-LIVER MICROSOMES	67	22
1170	3	1764 1972 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 46(3):1187-& ICHIKAWA Y; LOEHR JS NADH-DEPENDENT CYTOCHROME-P-450 OXIDASE SYSTEM IN SUBMICROSOMAL PARTICLES	30	22
1171	5	2200 1973 DRUG METABOLISM AND DISPOSITION 1(1):164-175 GILLETTE J; SASAME H; STRIPP B MECHANISMS OF INHIBITION OF DRUG METABOLIC REACTIONS	33	22
1172	4	2672 1975 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 168(2):609-621 WIEBEL FJ METABOLISM OF MONOHYDROXYBENZO(A)PYRENES BY RAT-LIVER MICROSOMES AND MAMMALIAN-CELLS IN CULTURE	74	22
1173	15	3410 1977 JOURNAL OF LIPID RESEARCH 18(2):135-153 MYANT NB; MITROPOULOS KA CHOLESTEROL 7ALPHA-HYDROXYLASE	360	22
1174	14	3570 1978 CHEMICO-BIOLOGICAL INTERACTIONS 21(1):29-43 WOLF CR; SZUTOWSKI MM; BALL LM; PHILPOT RM RABBIT PULMONARY MONO-OXYGENASE SYSTEM - CHARACTERISTICS AND ACTIVITIES OF 2 FORMS OF PULMONARY CYTOCHROME-P-450	74	22
1175	3	4010 1980 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 97(2):680-686 NABI N; OMURA T INVITRO SYNTHESIS OF ADRENODOXIN AND ADRENODOXIN REDUCTASE - EXISTENCE OF A PUTATIVE LARGE PRECURSOR FORM OF ADRENODOXIN	63	22
1176	3	4212 1980 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77(9):5216-5220 BENSON AM; HUNKELER MJ; TALALAY P INCREASE OF NAD(P)H-QUINONE REDUCTASE BY DIETARY ANTIOXIDANTS - POSSIBLE ROLE IN PROTECTION AGAINST CARCINOGENESIS AND TOXICITY	394	22
1177	12	4374 1981 JOURNAL OF BIOCHEMISTRY 89(1):237-248 HARADA N; OMURA T SELECTIVE INDUCTION OF 2 DIFFERENT MOLECULAR-SPECIES OF CYTOCHROME-P-450 BY PHENOBARBITAL AND 3-METHYLCHOLANTHRENE	146	22
1178	10	4531 1982 BIOCHEMICAL PHARMACOLOGY 31(3):383-390 AHR HJ; KING LJ; NASTAINCZYK W; ULLRICH V THE MECHANISM OF REDUCTIVE DEHALOGENATION OF HALOTHANE BY LIVER CYTOCHROME-P450	127	22
1179	40	4735 1982 XENOBIOTICA 12(11):787-800 KATO R; KAMATAKI T CYTOCHROME-P-450 AS A DETERMINANT OF SEX DIFFERENCE OF DRUG- METABOLISM IN THE RAT	98	22
1180	3	4966 1983 MOLECULAR PHARMACOLOGY 23(2):445-452 HALPERT J; NASLUND B; BETNER I SUICIDE INACTIVATION OF RAT-LIVER CYTOCHROME-P-450 BY CHLORAMPHENICOL INVIVO AND INVITRO	66	22
1181	19	5033 1984 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 232(2):585-596 TANIGUCHI H; IMAI Y; SATO R ROLE OF THE ELECTRON-TRANSFER SYSTEM IN MICROSOMAL DRUG MONOOXYGENASE REACTION CATALYZED BY CYTOCHROME-P-450	49	22
1182	16	5168 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(4):2541-2546 CANOVADAVIS E; WASKELL L THE IDENTIFICATION OF THE HEAT-STABLE MICROSOMAL PROTEIN REQUIRED FOR METHOXYFLURANE METABOLISM AS CYTOCHROME-B5	36	22
1183	10	5181 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(13):8672-8678 MATOCHA MF; WATERMAN MR DISCRIMINATORY PROCESSING OF THE PRECURSOR FORMS OF CYTOCHROME- P-450SCC AND ADRENODOXIN BY ADRENOCORTICAL AND HEART- MITOCHONDRIA	65	22
1184	10	5443 1985 JOURNAL OF CLINICAL INVESTIGATION 76(3):1218-1228 SHAK S; GOLDSTEIN IM LEUKOTRIENE-B4 OMEGA-HYDROXYLASE IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES - PARTIAL-PURIFICATION AND IDENTIFICATION AS A CYTOCHROME-P-450	136	22
1185	4	5953 1987 MOLECULAR PHARMACOLOGY 32(2):206-211 KELLEY M; HANTELLE P; SAFE S; LEVIN W; THOMAS PE COINDUCTION OF CYTOCHROME-P-450 ISOZYMES IN RAT-LIVER BY 2,4,5,2',4',5'-HEXACHLOROBIPHENYL OR 3-METHOXY-4- AMINOAZOBENZENE	35	22
1186	6	5972 1987 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(16):5858-5862 MATTESON KJ; PHILLIPS JA; MILLER WL; CHUNG BC; ORLANDO PJ; FRISCH H; FERRANDEZ A; BURR IM P450XXI (STEROID 21-HYDROXYLASE) GENE DELETIONS ARE NOT FOUND IN FAMILY STUDIES OF CONGENITAL ADRENAL-HYPERPLASIA	106	22
1187	4	6245 1988 JOURNAL OF BIOLOGICAL CHEMISTRY 263(33):17672-17677 JOHNSON EF; SCHWAB GE; VICKERY LE POSITIVE EFFECTORS OF THE BINDING OF AN ACTIVE SITE-DIRECTED AMINO STEROID TO RABBIT CYTOCHROME-P-450-3C	50	22
1188	8	6279 1988 MOLECULAR PHARMACOLOGY 33(2):148-154 BRADY JF; LEE MJ; LI M; ISHIZAKI H; YANG CS DIETHYL-ETHER AS A SUBSTRATE FOR ACETONE ETHANOL-INDUCIBLE CYTOCHROME-P-450 AND AS AN INDUCER FOR CYTOCHROME(S)-P-450	55	22
1189	5	6371 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 269(1):93-105 MATHIS JM; HOUSER WH; BRESNICK E; CIDLOWSKI JA; HINES RN; PROUGH RA; SIMPSON ER GLUCOCORTICOID REGULATION OF THE RAT CYTOCHROME-P450C (P4501A1) GENE - RECEPTOR-BINDING WITHIN INTRON-I	60	22
1190	10	6380 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 270(2):578-587 SHIMADA M; MURAYAMA N; YAMAUCHI K; YAMAZOE Y; KATO R SUPPRESSION IN THE EXPRESSION OF A MALE-SPECIFIC CYTOCHROME- P450, P450-MALE - DIFFERENCE IN THE EFFECT OF CHEMICAL INDUCERS ON P450-MALE MESSENGER-RNA AND PROTEIN IN RAT LIVERS	55	22
1191	10	6389 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 273(1):79-88 LORENCE MC; TRANT JM; MASON JI; BHASKER CR; FUJIIKURIYAMA Y; ESTABROOK RW; WATERMAN MR EXPRESSION OF A FULL-LENGTH CDNA-ENCODING BOVINE ADRENAL CYTOCHROME-P450C21	22	22
1192	5	6721 1989 MOLECULAR PHARMACOLOGY 36(5):723-729 STEGEMAN JJ; MILLER MR; HINTON DE CYTOCHROME-P450IA1 INDUCTION AND LOCALIZATION IN ENDOTHELIUM OF VERTEBRATE (TELEOST) HEART	71	22
1193	5	6822 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 276(2):424-432 NIZNIK HB; TYNDALE RF; SALLEE FR; GONZALEZ FJ; HARDWICK JP; INABA T; KALOW W THE DOPAMINE TRANSPORTER AND CYTOCHROME-P450IID1 (DEBRISOQUINE 4-HYDROXYLASE) IN BRAIN - RESOLUTION AND IDENTIFICATION OF 2 DISTINCT [H-3] GBR-12935 BINDING-PROTEINS	184	22
1194	12	6997 1990 CIRCULATION RESEARCH 67(5):1082-1088 CARROLL MA; GARCIA MP; FALCK JR; MCGIFF JC 5,6-EPOXYEICOSATRIENOIC ACID, A NOVEL ARACHIDONATE METABOLITE - MECHANISM OF VASOACTIVITY IN THE RAT	45	22
1195	6	7134 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(14):8190-8197 JELINEK DF; ANDERSSON S; SLAUGHTER CA; RUSSELL DW CLONING AND REGULATION OF CHOLESTEROL 7-ALPHA-HYDROXYLASE, THE RATE-LIMITING ENZYME IN BILE-ACID BIOSYNTHESIS	231	22
1196	6	7160 1990 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 70(4):1041-1045 DOODY KJ; LORENCE MC; MASON JI; SIMPSON ER EXPRESSION OF MESSENGER-RIBONUCLEIC-ACID SPECIES ENCODING STEROIDOGENIC ENZYMES IN HUMAN FOLLICLES AND CORPORA-LUTEA THROUGHOUT THE MENSTRUAL-CYCLE	96	22
1197	9	7163 1990 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 71(4):1036-1040 SONG BJ; VEECH RL; SAENGER P CYTOCHROME-P450IIE1 IS ELEVATED IN LYMPHOCYTES FROM POORLY CONTROLLED INSULIN-DEPENDENT DIABETICS	65	22
1198	11	7244 1990 MOLECULAR PHARMACOLOGY 38(4):440-444 KOCAREK TA; SCHUETZ EG; GUZELIAN PS DIFFERENTIATED INDUCTION OF CYTOCHROME-P450B/E AND CYTOCHROME- P450P MESSENGER-RNAS BY DOSE OF PHENOBARBITAL IN PRIMARY CULTURES OF ADULT-RAT HEPATOCYTES	64	22
1199	7	7468 1991 BRITISH JOURNAL OF CANCER 63(6):1021-1023 MURRAY GI; FOSTER CO; BARNES TS; WEAVER RJ; EWEN SWB; MELVIN WT; BURKE MD EXPRESSION OF CYTOCHROME-P450IA IN BREAST-CANCER	37	22
1200	7	7618 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(9):5898-5904 CLARK BJ; WATERMAN MR THE HYDROPHOBIC AMINO-TERMINAL SEQUENCE OF BOVINE 17-ALPHA- HYDROXYLASE IS REQUIRED FOR THE EXPRESSION OF A FUNCTIONAL HEMOPROTEIN IN COS 1 CELLS	49	22

#	Cited nodes	Nodes / Authors	GCS	LCS
1201	21	7703 1991 METHODS IN ENZYMOLOGY 206():31-49 SLIGAR SG; FILIPOVIC D; STAYTON PS MUTAGENESIS OF CYTOCHROMES-P450CAM AND B5	39	22
1202	7	7791 1991 TOXICOLOGY AND APPLIED PHARMACOLOGY 110(3):486-504 STEGEMAN JJ; SMOLOWITZ RM; HAHN ME IMMUNOHISTOCHEMICAL LOCALIZATION OF ENVIRONMENTALLY INDUCED CYTOCHROME-P450IA1 IN MULTIPLE ORGANS OF THE MARINE TELEOST STENOTOMUS-CHRYSOPS (SCUP)	56	22
1203	18	7933 1992 BIOCHEMISTRY 31(5):1528-1531 ISHIGOOKA M; SHIMIZU T; HIROYA K; HATANO M ROLE OF GLU318 AT THE PUTATIVE DISTAL SITE IN THE CATALYTIC FUNCTION OF CYTOCHROME-P450D	38	22
1204	14	8181 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(27):19503-19512 NAKAI K; WARD AM; GANNON M; RIFKIND AB BETA-NAPHTHOFLAVONE INDUCTION OF A CYTOCHROME-P-450 ARACHIDONIC-ACID EPOXYGENASE IN CHICK-EMBRYO LIVER DISTINCT FROM THE ARYL-HYDROCARBON HYDROXYLASE AND FROM PHENOBARBITAL- INDUCED ARACHIDONATE EPOXYGENASE	38	22
1205	25	8201 1992 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 6(3):235-252 LEWIS DFV; MOEREELS H THE SEQUENCE HOMOLOGIES OF CYTOCHROMES-P-450 AND ACTIVE-SITE GEOMETRIES	43	22
1206	6	8410 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 305(2):509-515 FAHRENDORF T; DIXON RA STRESS RESPONSES IN ALFALFA (MEDICAGO-SATIVA L) .18. MOLECULAR- CLONING AND EXPRESSION OF THE ELICITOR-INDUCIBLE CINNAMIC ACID 4-HYDROXYLASE CYTOCHROME-P450	62	22
1207	20	8577 1993 CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY 14(1):77-87 KAWAJIRI K; NAKACHI K; IMAI K; WATANABE J; HAYASHI S THE CYP1A1 GENE AND CANCER SUSCEPTIBILITY	137	22
1208	27	8807 1993 PHARMACOLOGICAL REVIEWS 45(4):413-453 GELBOIN HV CYTOCHROME-P450 AND MONOCLONAL-ANTIBODIES	58	22
1209	18	8925 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 314(1):234-241 SCHENKMAN JB; VOZNESENSKY AI; JANSSON I INFLUENCE OF IONIC-STRENGTH ON THE P450 MONOOXYGENASE REACTION AND ROLE OF CYTOCHROME B(5) IN THE PROCESS	30	22
1210	18	8956 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 205(3):1741-1747 JOUNAIDI Y; GUZELIAN PS; MAUREL P; VILAREM MJ SEQUENCE OF THE 5'-FLANKING REGION OF CYP3A5 - COMPARATIVE- ANALYSIS WITH CYP3A4 AND CYP3A7	34	22
1211	23	9196 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(22):15724-15731 VOZNESENSKY AI; SCHENKMAN JB QUANTITATIVE-ANALYSES OF ELECTROSTATIC INTERACTIONS BETWEEN NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME-P450 ENZYMES	41	22
1212	20	9224 1994 JOURNAL OF CLINICAL INVESTIGATION 94(6):2414-2420 MAKITA K; TAKAHASHI K; KARARA A; JACOBSON HR; FALCK JR; CAPDEVILA JH EXPERIMENTAL AND/OR GENETICALLY CONTROLLED ALTERATIONS OF THE RENAL MICROSOMAL CYTOCHROME-P450 EPOXYGENASE INDUCE HYPERTENSION IN RATS FED A HIGH-SALT DIET	62	22
1213	5	9320 1994 PHARMACEUTICAL RESEARCH 11(6):921-924 WRIGHTON SA; RING BJ INHIBITION OF HUMAN CYP3A CATALYZED 1'-HYDROXY MIDAZOLAM FORMATION BY KETOCONAZOLE, NIFEDIPINE, ERYTHROMYCIN, CIMETIDINE, AND NIZATIDINE	87	22
1214	14	9512 1995 BIOCHEMISTRY 34(28):8982-8988 MODI S; PRIMROSE WU; BOYLE JMB; GIBSON CF; LIAN LY; ROBERTS GCK NMR-STUDIES OF SUBSTRATE-BINDING TO CYTOCHROME-P-450 (BM3) - COMPARISONS TO CYTOCHROME-P-450 (CAM)	48	22
1215	15	9600 1995 DNA AND CELL BIOLOGY 14(1):73-82 COHEN MB; FEYEREISEN R A CLUSTER OF CYTOCHROME-P450 GENES OF THE CYP6 FAMILY IN THE HOUSE-FLY	31	22
1216	21	9947 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 327(1):11-19 Dong MS; Yamazaki H; Guo ZY; Guengerich FP Recombinant human cytochrome P450 1A2 and an N-terminal- truncated form: Construction, purification, aggregation properties, and interactions with Flavodoxin,Ferredoxin, and NADPH-cytochrome P450 reductase	34	22
1217	46	9963 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 330(1):87-96 Zeldin DC; Moomaw CR; Jesse N; Tomer KB; Beetham J; Hammock BD; Wu S Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway	35	22
1218	56	10124 1996 CRITICAL REVIEWS IN TOXICOLOGY 26(5):551-583 Guengerich FP; Gillam EMJ; Shimada T New applications of bacterial systems to problems in toxicology	43	22
1219	5	10132 1996 CYTOCHROME P450, PT B 272():44-51 Estabrook RW; Faulkner KM; Shet MS; Fisher CW Application of electrochemistry for P450-catalyzed reactions	22	22
1220	15	10194 1996 FASEB JOURNAL 10(7):683-689 Negishi M; Uno T; Darden TA; Sueyoshi T; Pedersen LG Structural flexibility and functional versatility of mammalian P450 enzymes	42	22
1221	24	10358 1996 MOLECULAR PHARMACOLOGY 50(5):1111-1117 Zeldin DC; Foley J; Ma JX; Boyle JE; Pascual JMS; Moomaw CR; Tomer KB; Steenbergen C; Wu S CYP2J subfamily P450s in the lung: Expression, localization, and potential functional significance	38	22
1222	42	10444 1996 XENOBIOTICA 26(7):723-753 Lewis DFV; Lake BG Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: Rationalization of CYP1A substrate specificity in terms of active site amino acid residues	45	22
1223	13	10604 1997 CARCINOGENESIS 18(2):391-397 Hakkola J; Pasanen M; Pelkonen O; Hukkanen J; Evisalmi S; Anttila S; Rane A; Mantyla M; Purkunen R; Saarikoski S; Tooming M; Raunio H Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells	66	22
1224	84	10867 1997 PHYSIOLOGICAL REVIEWS 77(2):517-544 Lieber CS Cytochrome P-4502E1: Its physiological and pathological role	181	22
1225	4	109 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(7):2134-2139 DEVLIN TM; BEDELL BH EFFECT OF ACETOACETATE ON THE OXIDATION OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE BY INTACT RAT LIVER MITOCHONDRIA	67	21
1226	3	126 1961 BIOCHIMICA ET BIOPHYSICA ACTA 52(1):106-& HATEFI Y; HAAVIK AG; JURTSHUK P STUDIES ON ELECTRON TRANSPORT SYSTEM .30. DPNH-CYTOCHROME C REDUCTASE 1	139	21
1227	1	300 1964 BIOCHIMICA ET BIOPHYSICA ACTA 86(2):427-& HOMMES FA; STEKHOVEN FMA APERIODIC CHANGES OF REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE DURING ANAEROBIC GLYCOLYSIS IN BREWERS YEAST	27	21
1228	6	720 1967 NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE 259(1):66-& UEHLEKE H STIMULATION OF SEVERAL MICROSOMAL DRUG OXIDATIONS BY PHENOBARBITAL METHYLCHOLANTHRENE AND CHLOROPHENOTHANE SINGLE AND IN COMBINATIONS	45	21
1229	8	726 1967 PLANT PHYSIOLOGY 42(11):1535-& IKUMA H; BONNER WD PROPERTIES OF HIGHER PLANT MITOCHONDRIA .3. EFFECTS OF RESPIRATORY INHIBITORS	81	21
1230	4	988 1969 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 36(5):795-& WHYSNER JA; RAMSEYER J; KAZMI GM; HARDING BW SUBSTRATE INDUCED SPIN STATE CHANGES IN CYTOCHROME P450	33	21
1231	5	1010 1969 BIOCHEMICAL PHARMACOLOGY 18(10):2561-& ANDERS MW STIMULATION IN VITRO OF MICROSOMAL ANILINE HYDROXYLATION BY 2,2'-BIPYRIDINE	36	21
1232	1	1015 1969 BIOCHEMISTRY 8(5):1821-& KOWAL J ADRENAL CELLS IN TISSUE CULTURE .3. EFFECT OF ADRENOCORTICOTROPIN AND 3',5'-CYCLIC ADENOSINE MONOPHOSPHATE ON 11 BETA-HYDROXYLASE AND OTHER STEROIDOGENIC ENZYMES	45	21
1233	10	1249 1970 BIOCHEMISTRY 9(7):1621-& WILSON LD; HARDING BW STUDIES ON ADRENAL CORTICAL CYTOCHROME-P-450 .4. EFFECTS OF CARBON MONOXIDE AND LIGHT ON CHOLESTEROL SIDE CHAIN CLEAVAGE	28	21
1234	5	1304 1970 FEBS LETTERS 6(3):249-& ORRENIUS S; KUPFER D; ERNSTER L SUBSTRATE BINDING TO CYTOCHROME P-450 OF LIVER AND ADRENAL MICROSOMES	25	21
1235	18	1335 1970 JOURNAL OF BIOCHEMISTRY 68(3):395-& KATO R; TAKANAKA A; TAKAYANA.M SUBSTRATE-INDUCED SPECTRAL CHANGE OF LIVER MICROSOMES IN PHENOBARBITAL AND METHYLCHOLANTHRENE-TREATED MALE AND FEMALE RATS	35	21
1236	17	1337 1970 JOURNAL OF BIOCHEMISTRY 68(4):529-& MITANI F; HORIE S STUDIES ON P-450 .7. RECONSTITUTION OF A STEROID 11 BETA- HYDROXYLATION SYSTEM USING A P-450 PREPARATION EXTRACTED AND PARTIALLY PURIFIED FROM ADRENOCORTICAL MITOCHONDRIA	28	21
1237	8	1351 1970 JOURNAL OF BIOLOGICAL CHEMISTRY 245(11):2789-& CARDINI G; JURTSHUK P ENZYMATIC HYDROXYLATION OF NORMAL-OCTANE BY CORYNEBACTERIUM SP STRAIN 7E1C	89	21
1238	12	1371 1970 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 175(1):4-& ALVARES AP; SCHILLIN.G; LEVIN W SPECIES DIFFERENCES IN INDUCTION OF MICROSOMAL HEMOPROTEINS AND 3,4-BENZPYRENE HYDROXYLASE BY PHENOBARBITAL AND 3- METHYLCHOLANTHRENE	68	21
1239	29	1432 1971 ANNUAL REVIEW OF BIOCHEMISTRY 40():237-& HESS B; BOITEWX A OSCILLATORY PHENOMENA IN BIOCHEMISTRY	352	21
1240	4	1621 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(12):3870-& RUSSELL DW METABOLISM OF AROMATIC COMPOUNDS IN HIGHER PLANTS .10. PROPERTIES OF CINNAMIC ACID 4-HYDROXYLASE OF PEA SEEDLINGS AND SOME ASPECTS OF ITS METABOLIC AND DEVELOPMENTAL CONTROL	123	21
1241	10	1741 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 150(1):227-& HOLTZMAN JL; CARR ML TEMPERATURE DEPENDENCE OF COMPONENTS OF HEPATIC MICROSOMAL MIXED-FUNCTION OXIDASES	48	21
1242	7	1960 1972 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 183(2):458-& FOUTS JR; DEVEREUX TR DEVELOPMENTAL ASPECTS OF HEPATIC AND EXTRAHEPATIC DRUG- METABOLIZING ENZYME-SYSTEMS - MICROSOMAL ENZYMES AND COMPONENTS IN RABBIT LIVVER AND LUNG DURING FIRST MONTH OF LIFE	100	21
1243	7	2218 1973 DRUG METABOLISM REVIEWS 2(1):1-32 GRAM TE COMPARATIVE ASPECTS OF MIXED-FUNCTION OXIDATION BY LUNG AND LIVER OF RABBITS	62	21
1244	7	2411 1974 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 57(1):93-99 WANG HP; PFEIFFER DR; KIMURA T; TCHEN TT PHOSPHOLIPIDS OF ADRENAL-CORTEX MITOCHONDRIA AND STEROID HYDROXYLASES - LIPID-ENVIRONMENT OF CYTOCHROME-P-450	48	21
1245	9	2668 1975 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 166(1):295-307 ARCHAKOV AI; DEVICHENSKII VM; KARJAKIN AV ELECTRON-TRANSFER IN MEMBRANES OF ENDOPLASMIC-RETICULUM - PARTICIPATION OF CYTOCHROME-B5 IN NADPH OXIDATION REACTION - EVIDENCE FOR 2 CYTOCHROMES-B5 IN LIVER-MICROSOMES	30	21
1246	6	2770 1975 CHEMICO-BIOLOGICAL INTERACTIONS 10(3):199-214 HOOK GER; HASEMAN JK; LUCIER GW INDUCTION AND SUPPRESSION OF HEPATIC AND EXTRAHEPATIC MICROSOMAL FOREIGN-COMPOUND-METABOLIZING ENZYME-SYSTEMS BY 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN	144	21
1247	19	2859 1975 JOURNAL OF CELLULAR PHYSIOLOGY 85(2):393-414 NEBERT DW; ROBINSON JR; NIWA A; KUMAKI K; POLAND AP GENETIC EXPRESSION OF ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY IN MOUSE	224	21
1248	14	2884 1975 MOLECULAR PHARMACOLOGY 11(2):190-200 LEVIN W; RYAN D; KUNTZMAN R; CONNEY AH NEONATAL IMPRINTING AND TURNOVER OF MICROSOMAL CYTOCHROME-P-450 IN RAT-LIVER	73	21
1249	5	3038 1976 CANCER RESEARCH 36(12):4439-4443 PROUGH RA; PATRIZI VW; ESTABROOK RW DIRECT SPECTROPHOTOMETRIC OBSERVATION OF BENZO(A)PYRENE PHENOL FORMATION BY LIVER-MICROSOMES	21	21
1250	11	3260 1977 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 76(3):666-673 PEDERSEN JI; OFTEBRO H; VANNGARD T ISOLATION FROM BOVINE LIVER-MITOCHONDRIA OF A SOLUBLE FERREDOXIN ACTIVE IN A RECONSTITUTED STEROID HYDROXYLATION REACTION	50	21
1251	80	3916 1979 MOLECULAR AND CELLULAR BIOCHEMISTRY 24(1):21-43 MITANI F CYTOCHROME-P450 IN ADRENOCORTICAL MITOCHONDRIA	54	21
1252	6	4005 1980 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 93(3):776-781 LUUTHE V; CUMPS J; DUMONT P METYRAPONE-REDUCED CYTOCHROME-P-450 COMPLEX - A SPECIFIC METHOD FOR THE DETERMINATION OF THE PHENOBARBITAL INDUCIBLE FORM OF RAT HEPATIC-MICROSOMAL CYTOCHROME-P-450	48	21
1253	19	4028 1980 BIOCHEMICAL PHARMACOLOGY 29(7):1015-1022 KAMATAKI T; ANDO M; YAMAZOE Y; ISHII K; KATO R SEX DIFFERENCE IN THE O-DEALKYLATION ACTIVITY OF 7- HYDROXYCOUMARIN O-ALKYL DERIVATIVES IN LIVER-MICROSOMES OF RATS	70	21
1254	16	4658 1982 JOURNAL OF BIOLOGICAL CHEMISTRY 257(12):7023-7029 KAWATO S; GUT J; CHERRY RJ; WINTERHALTER KH; RICHTER C ROTATION OF CYTOCHROME-P-450 .1. INVESTIGATIONS OF PROTEIN- PROTEIN INTERACTIONS OF CYTOCHROME-P-450 IN PHOSPHOLIPID- VESICLES AND LIVER-MICROSOMES	72	21
1255	11	4908 1983 JOURNAL OF BIOLOGICAL CHEMISTRY 258(5):3000-3005 KRAMER RE; SIMPSON ER; WATERMAN MR INDUCTION OF 11-BETA-HYDROXYLASE BY CORTICOTROPIN IN PRIMARY CULTURES OF BOVINE ADRENOCORTICAL-CELLS	60	21
1256	13	4920 1983 JOURNAL OF BIOLOGICAL CHEMISTRY 258(14):8684-8691 OPRIAN DD; GORSKY LD; COON MJ PROPERTIES OF THE OXYGENATED FORM OF LIVER MICROSOMAL CYTOCHROME-P-450	38	21
1257	2	5022 1984 ANALYTICAL BIOCHEMISTRY 142(2):340-346 LIU ZQ; FRANKLIN MR SEPARATION OF 4 GLUCURONIDES IN A SINGLE SAMPLE BY HIGH- PRESSURE LIQUID-CHROMATOGRAPHY AND ITS USE IN THE DETERMINATION OF UDP GLUCURONOSYLTRANSFERASE ACTIVITY TOWARD 4 AGLYCONES	37	21
1258	15	5167 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(4):2390-2395 WAGNER SL; DEAN WL; GRAY RD EFFECT OF A ZWITTERIONIC DETERGENT ON THE STATE OF AGGREGATION AND CATALYTIC ACTIVITY OF CYTOCHROME-P-450LM2 AND NADPH- CYTOCHROME P-450 REDUCTASE	55	21
1259	5	5222 1984 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81(6):1696-1700 CHESIS PL; LEVIN DE; SMITH MT; ERNSTER L; AMES BN MUTAGENICITY OF QUINONES - PATHWAYS OF METABOLIC-ACTIVATION AND DETOXIFICATION	310	21
1260	4	5628 1986 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 5(5):371-382 GOVIND S; BELL PA; KEMPER B STRUCTURE OF GENES IN THE CYTOCHROME-P-450PBC SUBFAMILY - CONSERVATION OF INTRON LOCATIONS IN THE PHENOBARBITAL-INDUCIBLE FAMILY	26	21
1261	3	5914 1987 JOURNAL OF BIOLOGICAL CHEMISTRY 262(12):5918-5923 JOHNSON EF; BARNES HJ; GRIFFIN KJ; OKINO S; TUKEY RH CHARACTERIZATION OF A 2ND GENE-PRODUCT RELATED TO RABBIT CYTOCHROME-P-450-1	24	21
1262	8	6178 1988 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 7(9):617-626 CHEN C; KALB VF; TURI TG; LOPER JC PRIMARY STRUCTURE OF THE CYTOCHROME-P450 LANOSTEROL 14-ALPHA- DEMETHYLASE GENE FROM CANDIDA-TROPICALIS	37	21
1263	14	6196 1988 EUROPEAN JOURNAL OF BIOCHEMISTRY 172(2):315-324 SUMIMOTO H; TAKESHIGE K; MINAKAMI S CHARACTERIZATION OF HUMAN NEUTROPHIL LEUKOTRIENE-B4 OMEGA- HYDROXYLASE AS A SYSTEM INVOLVING A UNIQUE CYTOCHROME-P-450 AND NADPH CYTOCHROME-P-450 REDUCTASE	48	21
1264	8	6290 1988 NEW ENGLAND JOURNAL OF MEDICINE 319(25):1639-1650 LIEBER CS BIOCHEMICAL AND MOLECULAR-BASIS OF ALCOHOL-INDUCED INJURY TO LIVER AND OTHER TISSUES	302	21
1265	8	6425 1989 BIOCHEMICAL JOURNAL 263(3):653-663 SHAW PM; BARNES TS; CAMERON D; ENGESET J; MELVIN WT; OMAR G; PETRIE JC; RUSH WR; SNYDER CP; WHITING PH; WOLF CR; BURKE MD PURIFICATION AND CHARACTERIZATION OF AN ANTICONVULSANT-INDUCED HUMAN CYTOCHROME-P-450 CATALYZING CYCLOSPORINE METABOLISM	60	21
1266	7	6527 1989 CHEMICAL RESEARCH IN TOXICOLOGY 2(6):367-374 HAMMONS GJ; ALWORTH WL; HOPKINS NE; GUENGERICH FP; KADLUBAR FF 2-ETHYNYLNAPHTHALENE AS A MECHANISM-BASED INACTIVATOR OF THE CYTOCHROME-P-450 CATALYZED N-OXIDATION OF 2-NAPHTHYLAMINE	36	21
1267	10	6648 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(30):17845-17853 OLIW EH BIOSYNTHESIS OF 18(RD)-HYDROXYEICOSATETRAENOIC ACID FROM ARACHIDONIC-ACID BY MICROSOMES OF MONKEY SEMINAL-VESICLES - SOME PROPERTIES OF A NOVEL FATTY-ACID OMEGA-3-HYDROXYLASE AND OMEGA-3-EPOXYGENASE	41	21
1268	8	6649 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(30):18076-18082 YANASE T; KAGIMOTO M; SUZUKI S; HASHIBA K; SIMPSON ER; WATERMAN MR DELETION OF A PHENYLALANINE IN THE N-TERMINAL REGION OF HUMAN CYTOCHROME-P-45017-ALPHA RESULTS IN PARTIAL COMBINED 17-ALPHA- HYDROXYLASE/17,20-LYASE DEFICIENCY	62	21
1269	15	6837 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 281(1):106-115 GRAVES PE; ELHAG GA; CIACCIO PJ; BOURQUE DP; HALPERT JR CDNA AND DEDUCED AMINO-ACID-SEQUENCES OF A DOG HEPATIC CYTOCHROME-P450IIB RESPONSIBLE FOR THE METABOLISM OF 2,2',4,4',5,5'-HEXACHLOROBIPHENYL	40	21
1270	9	6864 1990 BIOCHEMICAL JOURNAL 266(3):675-681 HENDERSON CJ; SCOTT AR; YANG CS; WOLF CR TESTOSTERONE-MEDIATED REGULATION OF MOUSE RENAL CYTOCHROME-P- 450 ISOENZYMES	44	21
1271	9	6918 1990 BIOCHEMISTRY 29(42):9819-9824 LORENCE MC; TRANT JM; CLARK BJ; KHYATT B; MASON JI; ESTABROOK RW; WATERMAN MR CONSTRUCTION AND EXPRESSION OF HUMAN-BOVINE P45017-ALPHA CHIMERIC PROTEINS - EVIDENCE FOR DISTINCT TERTIARY STRUCTURES IN THE SAME P450 FROM 2 DIFFERENT SPECIES	21	21
1272	6	7052 1990 ENVIRONMENTAL HEALTH PERSPECTIVES 88():13-25 NEBERT DW; PETERSEN DD; FORNACE AJ CELLULAR-RESPONSES TO OXIDATIVE STRESS - THE [AH] GENE BATTERY AS A PARADIGM	131	21
1273	2	7071 1990 FEBS LETTERS 268(1):137-140 NOSHIRO M; OKUDA K MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING HUMAN CHOLESTEROL 7-ALPHA-HYDROXYLASE	74	21
1274	2	7256 1990 NUCLEIC ACIDS RESEARCH 18(14):4237-4242 JAISWAL AK; HAAPARANTA T; LUC PV; SCHEMBRI J; ADESNIK M GLUCOCORTICOID REGULATION OF A PHENOBARBITAL-INDUCIBLE CYTOCHROME-P-450 GENE - THE PRESENCE OF A FUNCTIONAL GLUCOCORTICOID RESPONSE ELEMENT IN THE 5'-FLANKING REGION OF THE CYP2B2 GENE	50	21
1275	10	7278 1990 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87(14):5499-5503 VAZ ADN; ROBERTS ES; COON MJ REDUCTIVE BETA-SCISSION OF THE HYDROPEROXIDES OF FATTY-ACIDS AND XENOBIOTICS - ROLE OF ALCOHOL-INDUCIBLE CYTOCHROME-P-450	43	21
1276	13	7323 1990 XENOBIOTICA 20(9):887-900 PERSSON JO; TERELIUS Y; INGELMANSUNDBERG M CYTOCHROME-P-450-DEPENDENT FORMATION OF REACTIVE OXYGEN RADICALS - ISOZYME-SPECIFIC INHIBITION OF P-450-MEDIATED REDUCTION OF OXYGEN AND CARBON-TETRACHLORIDE	62	21
1277	9	7535 1991 DRUG METABOLISM AND DISPOSITION 19(3):561-567 BERTHOU F; FLINOIS JP; RATANASAVANH D; BEAUNE P; RICHE C; GUILLOUZO A EVIDENCE FOR THE INVOLVEMENT OF SEVERAL CYTOCHROMES-P-450 IN THE 1ST STEPS OF CAFFEINE METABOLISM BY HUMAN LIVER-MICROSOMES	93	21
1278	7	7641 1991 JOURNAL OF BIOLOGICAL CHEMISTRY 266(31):21030-21036 TEIXEIRA J; GIL G CLONING, EXPRESSION, AND REGULATION OF LITHOCHOLIC ACID 6-BETA- HYDROXYLASE	37	21
1279	2	7722 1991 MOLECULAR ENDOCRINOLOGY 5(10):1552-1561 RICE DA; MOUW AR; BOGERD AM; PARKER KL A SHARED PROMOTER ELEMENT REGULATES THE EXPRESSION OF 3 STEROIDOGENIC ENZYMES	156	21
1280	13	7958 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1123(2):156-162 KAWASHIMA H; KUSUNOSE E; KUBOTA I; MAEKAWA M; KUSUNOSE M PURIFICATION AND NH2-TERMINAL AMINO-ACID-SEQUENCES OF HUMAN AND RAT-KIDNEY FATTY-ACID OMEGA-HYDROXYLASES	26	21
1281	25	8173 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(20):14193-14203 PETERSON JA; LU JY; GEISSELSODER J; GRAHAMLORENCE S; CARMONA C; WITNEY F; LORENCE MC CYTOCHROME-P-450TERP - ISOLATION AND PURIFICATION OF THE PROTEIN AND CLONING AND SEQUENCING OF ITS OPERON	48	21
1282	54	8234 1992 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 43(8):779-804 HANUKOGLU I STEROIDOGENIC ENZYMES - STRUCTURE, FUNCTION, AND ROLE IN REGULATION OF STEROID-HORMONE BIOSYNTHESIS	121	21
1283	37	8241 1992 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 43(8):1055-1072 WAXMAN DJ REGULATION OF LIVER-SPECIFIC STEROID METABOLIZING CYTOCHROME- P450 - CHOLESTEROL 7-ALPHA-HYDROXYLASE, BILE-ACID 6-BETA- HYDROXYLASE, AND GROWTH HORMONE-RESPONSIVE STEROID-HORMONE HYDROXYLASES	62	21
1284	5	8380 1993 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 33():179-199 ZIEGLER DM RECENT STUDIES ON THE STRUCTURE AND FUNCTION OF MULTISUBSTRATE FLAVIN-CONTAINING MONOOXYGENASES	133	21
1285	8	8614 1993 EUROPEAN JOURNAL OF BIOCHEMISTRY 213(1):383-389 TODA K; SHIZUTA Y MOLECULAR-CLONING OF A CDNA SHOWING ALTERNATIVE SPLICING OF THE 5'-UNTRANSLATED SEQUENCE OF MESSENGER-RNA FOR HUMAN AROMATASE- P-450	40	21
1286	18	8700 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(29):21997-22003 STRAUB P; LLOYD M; JOHNSON EF; KEMPER B CASSETTE MUTAGENESIS OF A POTENTIAL SUBSTRATE RECOGNITION REGION OF CYTOCHROME-P450-2C2	34	21
1287	6	8914 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 310(2):332-340 MA RL; COHEN MB; BERENBAUM MR; SCHULER MA BLACK SWALLOWTAIL (PAPILIO POLYXENES) ALLELES ENCODE CYTOCHROME P450S THAT SELECTIVELY METABOLIZE LINEAR FURANOCOUMARINS	44	21
1288	19	9030 1994 CANCER RESEARCH 54(1):101-108 GALLAGHER EP; WIENKERS LC; STAPLETON PL; KUNZE KL; EATON DL ROLE OF HUMAN MICROSOMAL AND HUMAN COMPLEMENTARY DNA-EXPRESSED CYTOCHROME-P4501A2 AND CYTOCHROME-P4503A4 IN THE BIOACTIVATION OF AFLATOXIN-B(1)	92	21
1289	19	9506 1995 BIOCHEMICAL PHARMACOLOGY 50(12):2047-2056 Debri K; Boobis AR; Edwards RJ Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues	44	21
1290	18	9572 1995 CHEMICAL RESEARCH IN TOXICOLOGY 8(4):574-579 HE YQ; HE YA; HALPERT JR ESCHERICHIA-COLI EXPRESSION OF SITE-DIRECTED MUTANTS OF CYTOCHROME-P450 2B1 FROM 6 SUBSTRATE RECOGNITION SITES - SUBSTRATE-SPECIFICITY AND INHIBITOR SELECTIVITY STUDIES	47	21
1291	26	9976 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 333(2):447-458 Haining RL; Hunter AP; Veronese ME; Trager WF; Rettie AE Allelic variants of human cytochrome P450 2C9: Baculovirus- mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms	94	21
1292	11	10261 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(51):33054-33059 Gilday D; Gannon M; Yutzey K; Bader D; Rifkind AB Molecular cloning and expression of two novel avian cytochrome p450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin	48	21
1293	15	10344 1996 MOLECULAR PHARMACOLOGY 49(1):63-72 Schuetz JD; Schuetz EG; Thottassery JV; Guzelian PS; Strom S; Sun D Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells	50	21
1294	28	10511 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 346(1):161-169 Yamazaki H; Shimada T Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes	48	21
1295	12	10652 1997 DRUG METABOLISM AND DISPOSITION 25(4):502-507 Wang RW; Newton DJ; Scheri TD; Lu AYH Human cytochrome P450 3A4-catalyzed testosterone 6 beta- hydroxylation and erythromycin N-demethylation - Competition during catalysis	46	21
1296	25	10833 1997 MOLECULAR PHARMACOLOGY 51(6):931-943 Zeldin DC; Foley J; Goldsworthy SM; Cook ME; Boyle JE; Ma JX; Moomaw CR; Tomer KB; Steenbergen C; Wu S CYP2J subfamily cytochrome P450s in the gastrointestinal tract: Expression, localization, and potential functional significance	31	21
1297	13	11375 1998 PHARMACOTHERAPY 18(1):84-112 Michalets EL Update: Clinically significant cytochrome P-450 drug interactions	209	21
1298	3	201 1963 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 11(1):1-& HOMMES F; ESTABROOK RW ROLE OF TRANSHYDROGENASE IN ENERGY-LINKED REDUCTION OF TPN	20	20
1299	7	205 1963 BIOCHEMISCHE ZEITSCHRIFT 338():335-& GREEN DE; WHARTON DC STOICHIOMETRY OF FIXED OXIDATION-REDUCTION COMPONENTS OF ELECTRON TRANSFER CHAIN OF BEEF HEART MITOCHONDRIA	107	20
1300	10	462 1966 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 115(2):373-& TYLER DD; GONZE J; ESTABROOK RW OBSERVATIONS ON INHIBITOR SENSITIVITY OF CHOLINE OXIDATION SYSTEM	20	20

#	Cited nodes	Nodes / Authors	GCS	LCS
1301	12	871 1968 JOURNAL OF BIOCHEMISTRY 63(3):380-& IMAI Y; SATO R DUAL EFFECT OF ETHYL ISOCYANIDE ON DRUG HYDROXYLATION BY LIVER MICROSOMES	23	20
1302	3	902 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(22):6070-& CARDINI G; JURTSHUK P CYTOCHROME P-450 INVOLVEMENT IN OXIDATION OF N-OCTANE BY CELL- FREE EXTRACTS OF CORYNEBACTERIUM SP STRAIN 7E1C	52	20
1303	4	1382 1970 LIFE SCIENCES PT-2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY 9(15):877-& HUTTERER F; DENK H; BACCHIN PG; SCKENKMA.JB; SCHAFFNE.F; POPPER H MECHANISM OF CHOLESTASIS .1. EFFECT OF BILE ACIDS ON MICROSOMAL CYTOCHROME-P-450 DEPENDENT BIOTRANSFORMATION SYSTEM IN-VITRO	90	20
1304	5	1495 1971 BIOCHEMICAL PHARMACOLOGY 20(6):1061-& AUST SD; STEVENS JB AMINOPYRINE DEMETHYLASE - MULTIPLICITY SHOWN BY DIELDRIN AND DDT INHIBITION	36	20
1305	6	1585 1971 EXPERIMENTAL AND MOLECULAR PATHOLOGY 14(2):263-& DENK H; SCHENKMAN JB; BACCHIN PG; HUTTERER F; SCHAFFNE.F; POPPER H MECHANISM OF CHOLESTASIS .3. INTERACTION OF SYNTHETIC DETERGENTS WITH MICROSOMAL CYTOCHROME-P-450 DEPENDENT BIOTRANSFORMATION SYSTEM IN-VITRO - COMPARISON BETWEEN EFFECTS OF DETERGENTS, EFFECTS OF BILE ACIDS, AND FINDINGS IN BILE DUCT LIGATED RATS	42	20
1306	22	1625 1971 JOURNAL OF BIOLOGICAL CHEMISTRY 246(17):5189-& GIELEN JE; NEBERT DW ARYL HYDROCARBON HYDROXYLASE INDUCTION IN MAMMALIAN LIVER CELL CULTURE .1. STIMULATION OF ENZYME ACTIVITY IN NONHEPATIC CELLS AND IN HEPATIC CELLS BY PHENOBARBITAL, POLYCYCLIC HYDROCARBONS, AND 2,2-BIS(P-CHLOROPHENYL)-1,1,1-TRICHLOROETHANE	101	20
1307	12	1683 1971 NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE 270(1):41-& BOHN W; ULLRICH V; STAUDING.H SPECIES OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES WITH DIFFERENT STEREOSELECTIVITY FOR BINDING AND MONOOXYGENATION OF (+)-METHYLPHENOBARBITAL AND (-)-METHYLPHENOBARBITAL	32	20
1308	15	1746 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 150(2):725-& PEISACH J; BLUMBERG WE; APPLEBY CA ELECTRON-PARAMAGNETIC RESONANCE AND TEMPERATURE DEPENDENT SPIN STATE STUDIES OF FERRIC CYTOCHROME-P-450 FROM RHIZOBIUM- JAPONICUM	43	20
1309	14	2074 1973 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 159(1):240-248 ULLRICH V; SCHNABEL KH FORMATION AND LIGAND BINDING OF FLUORENYL CARBANION BY HEPATIC CYTOCHROME P450	31	20
1310	7	2631 1974 XENOBIOTICA 4(3):143-150 FRANKLIN MR INHIBITION OF METABOLISM OF N-SUBSTITUTED AMPHETAMINES BY SKF 525-A AND RELATED COMPOUNDS	27	20
1311	31	3101 1976 FEDERATION PROCEEDINGS 35(13):2460-2463 LU AYH LIVER MICROSOMAL DRUG-METABOLIZING ENZYME-SYSTEM - FUNCTIONAL COMPONENTS AND THEIR PROPERTIES	88	20
1312	7	3403 1977 JOURNAL OF BIOLOGICAL CHEMISTRY 252(18):6373-6378 ALVARES AP; KAPPAS A HETEROGENEITY OF CYTOCHROME P-450S INDUCED BY POLYCHLORINATED BIPHENYLS	130	20
1313	5	3416 1977 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 201(2):498-506 THURMAN RG; MARAZZO DP; JONES LS; KAUFFMAN FC CONTINUOUS KINETIC DETERMINATION OF PARA-NITROANISOLE O- DEMETHYLATION IN HEMOGLOBIN-FREE PERFUSED RAT-LIVER	69	20
1314	2	3498 1978 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 82(2):518-525 CAPDEVILA J; ESTABROOK RW; PROUGH RA MICROSOMAL METABOLISM OF BENZO(A)PYRENE PHENOLS	20	20
1315	10	3513 1978 BIOCHEMICAL PHARMACOLOGY 27(3):355-358 AUCLAIR C; DEPROST D; HAKIM J SUPEROXIDE ANION PRODUCTION BY LIVER-MICROSOMES FROM PHENOBARBITAL TREATED RAT	47	20
1316	13	3516 1978 BIOCHEMICAL PHARMACOLOGY 27(5):783-788 ALGAILANY KAS; HOUSTON JB; BRIDGES JW ROLE OF SUBSTRATE LIPOPHILICITY IN DETERMINING TYPE-1 MICROSOMAL P450 BINDING CHARACTERISTICS	47	20
1317	16	3582 1978 DRUG METABOLISM AND DISPOSITION 6(4):353-362 WARNER M; LAMARCA MV; NEIMS AH CHROMATOGRAPHIC AND ELECTROPHORETIC HETEROGENEITY OF CYTOCHROMES P-450 SOLUBILIZED FROM UNTREATED RAT-LIVER	114	20
1318	12	3650 1978 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 207(3):719-725 ZENSER TV; MATTAMMAL MB; DAVIS BB DIFFERENTIAL DISTRIBUTION OF THE MIXED-FUNCTION OXIDASE ACTIVITIES IN RABBIT KIDNEY	123	20
1319	19	3767 1979 BIOCHEMICAL PHARMACOLOGY 28(2):231-238 DICKINS M; ELCOMBE CR; MOLONEY SJ; NETTER KJ; BRIDGES JW FURTHER-STUDIES ON THE DISSOCIATION OF THE ISOSAFROLE METABOLITE-CYTOCHROME-P-450 COMPLEX	50	20
1320	10	3926 1979 MOLECULAR PHARMACOLOGY 16(1):332-342 BOSTERLING B; STIER A; HILDEBRANDT AG; DAWSON JH; TRUDELL JR RECONSTITUTION OF CYTOCHROME-P-450 AND CYTOCHROME-P-450 REDUCTASE INTO PHOSPHATIDYLCHOLINE-PHOSPHATIDYLETHANOLAMINE BILAYERS - CHARACTERIZATION OF STRUCTURE AND METABOLIC-ACTIVITY	52	20
1321	6	4011 1980 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 97(3):860-867 BACKES WL; SLIGAR SG; SCHENKMAN JB CYTOCHROME-P-450 REDUCTION EXHIBITS BURST KINETICS	23	20
1322	5	4038 1980 BIOCHEMICAL PHARMACOLOGY 29(20):2855-2861 AHR HJ; KING LJ; NASTAINCZYK W; ULLRICH V THE MECHANISM OF CHLOROFORM AND CARBON-MONOXIDE FORMATION FROM CARBON-TETRACHLORIDE BY MICROSOMAL CYTOCHROME-P-450	99	20
1323	17	4733 1982 XENOBIOTICA 12(11):745-772 DUS KM INSIGHTS INTO THE ACTIVE-SITE OF THE CYTOCHROME-P-450 HEMOPROTEIN FAMILY - A UNIFYING CONCEPT BASED ON STRUCTURAL CONSIDERATIONS	40	20
1324	9	4945 1983 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 105(5):1380-1381 KUNZE KL; DEMONTELLANO PRO FORMATION OF A SIGMA-BONDED ARYLIRON COMPLEX IN THE REACTION OF ARYLHYDRAZINES WITH HEMOGLOBIN AND MYOGLOBIN	78	20
1325	6	5032 1984 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 232(1):366-377 MOREHOUSE LA; THOMAS CE; AUST SD SUPEROXIDE GENERATION BY NADPH-CYTOCHROME-P-450 REDUCTASE - THE EFFECT OF IRON CHELATORS AND THE ROLE OF SUPEROXIDE IN MICROSOMAL LIPID-PEROXIDATION	117	20
1326	6	5035 1984 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 233(2):636-642 RYAN DE; DIXON R; EVANS RH; RAMANATHAN L; THOMAS PE; WOOD AW; LEVIN W RAT HEPATIC CYTOCHROME-P-450 ISOZYME SPECIFICITY FOR THE METABOLISM OF THE STEROID SULFATE, 5-ALPHA-ANDROSTANE-3-ALPHA, 17-BETA-DIOL-3,17-DISULFATE	49	20
1327	20	5251 1984 XENOBIOTICA 14(1-2):105-118 CAPDEVILA J; SAEKI Y; FALCK JR THE MECHANISTIC PLURALITY OF CYTOCHROME-P-450 AND ITS BIOLOGICAL RAMIFICATIONS	42	20
1328	3	5629 1986 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 5(5):403-411 NEUHOLD LA; GONZALEZ FJ; JAISWAL AK; NEBERT DW DIOXIN-INDUCIBLE ENHANCER REGION UPSTREAM FROM THE MOUSE P1450 GENE AND INTERACTION WITH A HETEROLOGOUS SV40 PROMOTER	60	20
1329	8	5734 1986 TETRAHEDRON LETTERS 27(50):6035-6038 MOSSET P; YADAGIRI P; LUMIN S; CAPDEVILA J; FALCK JR ARACHIDONATE EPOXYGENASE - TOTAL SYNTHESIS OF BOTH ENANTIOMERS OF 8,9-EPOXYEICOSATRIENOIC AND 11,12-EPOXYEICOSATRIENOIC ACID	31	20
1330	9	6016 1988 AMERICAN JOURNAL OF THE MEDICAL SCIENCES 295(4):275-279 LAPUERTA L; CHACOS N; FALCK JR; JACOBSON H; CAPDEVILA JH RENAL MICROSOMAL CYTOCHROME-P-450 AND THE OXIDATIVE-METABOLISM OF ARACHIDONIC-ACID	39	20
1331	18	6037 1988 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 265(1):159-170 IMAOKA S; INOUE K; FUNAE Y AMINOPYRINE METABOLISM BY MULTIPLE FORMS OF CYTOCHROME-P-450 FROM RAT-LIVER MICROSOMES - SIMULTANEOUS QUANTITATION OF 4 AMINOPYRINE METABOLITES BY HIGH-PERFORMANCE LIQUID- CHROMATOGRAPHY	44	20
1332	9	6464 1989 BIOCHEMISTRY 28(14):5832-5839 MCCLELLANGREEN PD; NEGISHI M; GOLDSTEIN JA CHARACTERIZATION OF A CDNA FOR RAT P-450G, A HIGHLY POLYMORPHIC, MALE-SPECIFIC CYTOCHROME IN THE P-450IIC SUBFAMILY	25	20
1333	3	6517 1989 CARCINOGENESIS 10(5):885-891 DAVIES RL; CRESPI CL; RUDO K; TURNER TR; LANGENBACH R DEVELOPMENT OF A HUMAN CELL-LINE BY SELECTION AND DRUG- METABOLIZING GENE TRANSFECTION WITH INCREASED CAPACITY TO ACTIVATE PROMUTAGENS	69	20
1334	16	6523 1989 CHEMICAL RESEARCH IN TOXICOLOGY 2(3):131-141 OSAWA Y; POHL LR COVALENT BONDING OF THE PROSTHETIC HEME TO PROTEIN - A POTENTIAL MECHANISM FOR THE SUICIDE INACTIVATION OR ACTIVATION OF HEMOPROTEINS	69	20
1335	6	6548 1989 DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY 8(3):179-191 HANSEN AJ; MAY BK SEQUENCE OF A CHICKEN PHENOBARBITAL-INDUCIBLE CYTOCHROME-P450 CDNA - REGULATION OF 2 P450 MESSENGER-RNAS TRANSCRIBED FROM DIFFERENT GENES	44	20
1336	9	6839 1990 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 281(2):204-211 BURGER HJ; SCHUETZ EG; SCHUETZ JD; GUZELIAN PS DIVERGENT EFFECTS OF CYCLOHEXIMIDE ON THE INDUCTION OF CLASS-II AND CLASS-III CYTOCHROME P450 MESSENGER-RNAS IN CULTURES OF ADULT-RAT HEPATOCYTES	39	20
1337	14	6940 1990 BIOCHIMICA ET BIOPHYSICA ACTA 1043(2):177-181 TANAKA S; IMAOKA S; KUSUNOSE E; KUSUNOSE M; MAEKAWA M; FUNAE Y OMEGA-HYDROXYLATION AND (OMEGA-1)-HYDROXYLATION OF ARACHIDONIC- ACID, LAURIC ACID AND PROSTAGLANDIN-A1 BY MULTIPLE FORMS OF CYTOCHROME-P-450 PURIFIED FROM RAT HEPATIC MICROSOMES	36	20
1338	7	7081 1990 GASTROENTEROLOGY 99(4):1044-1053 SHIMIZU M; LASKER JM; TSUTSUMI M; LIEBER CS IMMUNOHISTOCHEMICAL LOCALIZATION OF ETHANOL-INDUCIBLE P450IIE1 IN THE RAT ALIMENTARY-TRACT	66	20
1339	7	7112 1990 JOURNAL OF BIOCHEMISTRY 107(2):280-286 KIKUTA Y; KUSUNOSE E; OKUMOTO T; KUBOTA I; KUSUNOSE M PURIFICATION AND CHARACTERIZATION OF 2 FORMS OF CYTOCHROME-P- 450 WITH OMEGA-HYDROXYLASE ACTIVITIES TOWARD PROSTAGLANDIN-A AND FATTY-ACIDS FROM RABBIT LIVER-MICROSOMES	27	20
1340	6	7140 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(19):11299-11305 KAGAWA N; WATERMAN MR CAMP-DEPENDENT TRANSCRIPTION OF THE HUMAN CYP21B (P-450C21) GENE REQUIRES A CIS-REGULATORY ELEMENT DISTINCT FROM THE CONSENSUS CAMP-REGULATORY ELEMENT	70	20
1341	7	7214 1990 METHODS IN ENZYMOLOGY 187():357-364 FALCK JR; YADAGIRI P; CAPDEVILA J SYNTHESIS OF EPOXYEICOSATRIENOIC ACIDS AND HETEROATOM ANALOGS	34	20
1342	21	7373 1991 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 291(1):176-186 KEDZIE KM; PHILPOT RM; HALPERT JR FUNCTIONAL EXPRESSION OF MAMMALIAN CYTOCHROMES-P450IIB IN THE YEAST SACCHAROMYCES-CEREVISIAE	30	20
1343	15	7585 1991 GASTROENTEROLOGY 101(6):1680-1691 KNODELL RG; BROWNE DG; GWOZDZ GP; BRIAN WR; GUENGERICH FP DIFFERENTIAL INHIBITION OF INDIVIDUAL HUMAN LIVER CYTOCHROMES- P-450 BY CIMETIDINE	100	20
1344	16	7923 1992 BIOCHEMICAL PHARMACOLOGY 44(2):275-283 HUNT CM; WESTERKAM WR; STAVE GM EFFECT OF AGE AND GENDER ON THE ACTIVITY OF HUMAN HEPATIC-CYP3A	125	20
1345	3	7944 1992 BIOCHEMISTRY 31(51):12855-12862 JUNG C; HOA GHB; SCHRODER KL; SIMON M; DOUCET JP SUBSTRATE-ANALOG INDUCED CHANGES OF THE CO-STRETCHING MODE IN THE CYTOCHROME-P450CAM-CARBON MONOXIDE COMPLEX	60	20
1346	20	8100 1992 FASEB JOURNAL 6(2):695-699 DEMONTELLANO PRO; CHAN WK; TUCK SF; KAIKAUS RM; BASS NM; PETERSON JA MECHANISM-BASED PROBES OF THE TOPOLOGY AND FUNCTION OF FATTY- ACID HYDROXYLASES	42	20
1347	8	8165 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(10):6991-6998 OKINO ST; PENDURTHI UR; TUKEY RH PHORBOL ESTERS INHIBIT THE DIOXIN RECEPTOR-MEDIATED TRANSCRIPTIONAL ACTIVATION OF THE MOUSE CYP1A-1 AND CYP1A-2 GENES BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN	85	20
1348	6	8170 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(17):11789-11793 ALVAREZ J; MONTERO M; GARCIASANCHO J HIGH-AFFINITY INHIBITION OF CA2+-DEPENDENT K+ CHANNELS BY CYTOCHROME-P-450 INHIBITORS	157	20
1349	20	8220 1992 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 262(1):433-438 LAETHEM RM; LAETHEM CL; DING XX; KOOP DR P-450-DEPENDENT ARACHIDONIC-ACID METABOLISM IN RABBIT OLFACTORY MICROSOMES	26	20
1350	12	8307 1992 PLANT PHYSIOLOGY 100(4):1976-1981 BOZAK KR; OKEEFE DP; CHRISTOFFERSEN RE EXPRESSION OF A RIPENING-RELATED AVOCADO (PERSEA-AMERICANA) CYTOCHROME P450 IN YEAST	35	20
1351	12	8315 1992 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89(12):5567-5571 BODDUPALLI SS; HASEMANN CA; RAVICHANDRAN KG; LU JY; GOLDSMITH EJ; DEISENHOFER J; PETERSON JA CRYSTALLIZATION AND PRELIMINARY-X-RAY DIFFRACTION ANALYSIS OF P450TERP AND THE HEMOPROTEIN DOMAIN OF P450BM-3, ENZYMES BELONGING TO 2 DISTINCT CLASSES OF THE CYTOCHROME P450 SUPERFAMILY	35	20
1352	14	8388 1993 AQUATIC TOXICOLOGY 26(3-4):185-208 HAHN ME; LAMB TM; SCHULTZ ME; SMOLOWITZ RM; STEGEMAN JJ CYTOCHROME-P4501A INDUCTION AND INHIBITION BY 3,3',4,4'- TETRACHLOROBIPHENYL IN AN AH RECEPTOR-CONTAINING FISH HEPATOMA- CELL LINE (PLHC-1)	140	20
1353	17	8456 1993 BIOCHEMICAL PHARMACOLOGY 45(5):1035-1042 MAENPAA J; SIGUSCH H; RAUNIO H; SYNGELMA T; VUORELA P; VUORELA H; PELKONEN O DIFFERENTIAL INHIBITION OF COUMARIN 7-HYDROXYLASE ACTIVITY IN MOUSE AND HUMAN LIVER-MICROSOMES	58	20
1354	13	8474 1993 BIOCHEMICAL PHARMACOLOGY 46(4):621-627 SHIMOJO N; ISHIZAKI T; IMAOKA S; FUNAE Y; FUJII S; OKUDA K CHANGES IN AMOUNTS OF CYTOCHROME-P450 ISOZYMES AND LEVELS OF CATALYTIC ACTIVITIES IN HEPATIC AND RENAL MICROSOMES OF RATS WITH STREPTOZOCIN-INDUCED DIABETES	55	20
1355	19	8691 1993 JOURNAL OF BIOLOGICAL CHEMISTRY 268(23):17253-17260 PENG HM; DING XX; COON MJ ISOLATION AND HETEROLOGOUS EXPRESSION OF CLONED CDNAS FOR 2 RABBIT NASAL MICROSOMAL PROTEINS, CYP2A10 AND CYP2A11, THAT ARE RELATED TO NASAL MICROSOMAL CYTOCHROME-P450 FORM A	32	20
1356	17	8896 1994 ANALYTICAL BIOCHEMISTRY 219(2):309-320 RODRIGUES AD; KUKULKA MJ; SURBER BW; THOMAS SB; UCHIC JT; ROTERT GA; MICHEL G; THOMEKROMER B; MACHINIST JM MEASUREMENT OF LIVER MICROSOMAL CYTOCHROME-P450 (CYP2D6) ACTIVITY USING [O-METHYL-C-14] DEXTROMETHORPHAN	52	20
1357	15	8911 1994 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 310(1):126-133 BLACK SD; LINGER MH; FRECK LC; KAZEMI S; GALBRAITH JA AFFINITY ISOLATION AND CHARACTERIZATION OF CYTOCHROME-P450-102 (BM-3) FROM BARBITURATE-INDUCED BACILLUS-MEGATERIUM	23	20
1358	16	9033 1994 CANCER RESEARCH 54(11):2878-2886 PROUGH RA; WEBB SJ; WU HQ; LAPENSON DP; WAXMAN DJ INDUCTION OF MICROSOMAL AND PEROXISOMAL ENZYMES BY DEHYDROEPIANDROSTERONE AND ITS REDUCED METABOLITE IN RATS	40	20
1359	30	9119 1994 EUROPEAN JOURNAL OF BIOCHEMISTRY 226(3):877-882 ITOH S; SATOH M; ABE Y; HASHIMOTO H; YANAGIMOTO T; KAMATAKI T A NOVEL FORM OF MOUSE CYTOCHROME-P450 3A (CYP3A-16) - ITS CDNA CLONING AND EXPRESSION IN FETAL LIVER	34	20
1360	18	9175 1994 JOURNAL OF BIOCHEMISTRY 115(2):338-344 FUKUDA T; IMAI Y; KOMORI M; NAKAMURA M; KUSUNOSE E; SATOUCHI K; KUSUNOSE M DIFFERENT MECHANISMS OF REGIOSELECTION OF FATTY-ACID HYDROXYLATION BY LAURATE (OMEGA-1)-HYDROXYLATING P450S, P450 2C2 AND P450 2E1	28	20
1361	19	9176 1994 JOURNAL OF BIOCHEMISTRY 116(1):74-80 KAWASHIMA H; KUSUNOSE E; KIKUTA Y; KINOSHITA H; TANAKA S; YAMAMOTO S; KISHIMOTO T; KUSUNOSE M PURIFICATION AND CDNA CLONING OF HUMAN LIVER CYP4A FATTY-ACID OMEGA-HYDROXYLASE	25	20
1362	8	9264 1994 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 51(5-6):251-258 SPINK DC; HAYES CL; YOUNG NR; CHRISTOU M; SUTTER TR; JEFCOATE CR; GIERTHY JF THE EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN ON ESTROGEN METABOLISM IN MCF-7 BREAST-CANCER CELLS - EVIDENCE FOR INDUCTION OF A NOVEL 17-BETA-ESTRADIOL 4-HYDROXYLASE	102	20
1363	24	9302 1994 MOLECULAR PHARMACOLOGY 45(6):1273-1280 KNICKLE LC; BEND JR BIOACTIVATION OF ARACHIDONIC-ACID BY THE CYTOCHROME-P450 MONOOXYGENASES OF GUINEA-PIG LUNG - THE ORTHOLOGUE OF CYTOCHROME-P450-2B4 IS SOLELY RESPONSIBLE FOR FORMATION OF EPOXYEICOSATRIENOIC ACIDS	39	20
1364	15	9390 1994 XENOBIOTICA 24(6):517-526 CLARKE SE; AYRTON AD; CHENERY RJ CHARACTERIZATION OF THE INHIBITION OF P4501A2 BY FURAFYLLINE	48	20
1365	15	9478 1995 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 217(3):1137-1144 Kawashima H; Strobel HW cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily	39	20
1366	14	9484 1995 BIOCHEMICAL PHARMACOLOGY 49(1):39-47 EDWARDS RJ; SINGLETON AM; MURRAY BP; DAVIES DS; BOOBIS AR SHORT SYNTHETIC PEPTIDES EXPLOITED FOR RELIABLE AND SPECIFIC TARGETING OF ANTIBODIES TO THE C-TERMINI OF CYTOCHROME-P450 ENZYMES	42	20
1367	19	9513 1995 BIOCHEMISTRY 34(33):10365-10375 MANCY A; BROTO P; DIJOLS S; DANSETTE PM; MANSUY D THE SUBSTRATE-BINDING SITE OF HUMAN LIVER CYTOCHROME-P450 2C9 - AN APPROACH USING DESIGNED TIENILIC ACID-DERIVATIVES AND MOLECULAR MODELING	58	20
1368	16	9521 1995 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1260(3):341-344 STROTKAMP D; ROOS PH; HANSTEIN WG A NOVEL CYP3 GENE FROM FEMALE RATS	32	20
1369	52	9742 1995 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 15(6):387-398 KETTER TA; FLOCKHART DA; POST RM; DENICOFF K; PAZZAGLIA PJ; MARANGELL LB; GEORGE MS; CALLAHAN AM THE EMERGING ROLE OF CYTOCHROME-P450 3A IN PSYCHOPHARMACOLOGY	118	20
1370	4	9834 1995 PHARMACOGENETICS 5(1):1-17 VATSIS KP; WEBER WW; BELL DA; DUPRET JM; EVANS DAP; GRANT DM; HEIN DW; LIN HJ; MEYER UA; RELLING MV; SIM E; SUZUKI T; YAMAZOE Y NOMENCLATURE FOR N-ACETYLTRANSFERASES	245	20
1371	7	9859 1995 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92(11):5134-5138 PINEAU T; FERNANDEZSALGUERO P; LEE SST; MCPHAIL T; WARD JM; GONZALEZ FJ NEONATAL LETHALITY ASSOCIATED WITH RESPIRATORY-DISTRESS IN MICE LACKING CYTOCHROME-P450 1A2	55	20
1372	23	9975 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 333(1):308-315 Estabrook RW; Shet MS; Fisher CW; Jenkins CM; Waterman MR The interaction of NADPH-P450 reductase with P450: An electrochemical study of the role of the flavin mononucleotide- binding domain	20	20
1373	11	10196 1996 FASEB JOURNAL 10(11):1241-1248 Johnson EF; Palmer CNA; Griffin KJ; Hsu MH Cytochromes P450 .7. Role of the peroxisome proliferator- activated receptor in cytochrome P450 4A gene regulation	70	20
1374	14	10492 1997 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 339(1):218-225 Shet MS; Fisher CW; Estabrook RW The function of recombinant cytochrome P450s in intact Escherichia coli cells: The l7 alpha-hydroxylation of progesterone and pregnenolone by p450c17	20	20
1375	31	11263 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(27):17036-17049 Bridges A; Gruenke L; Chang YT; Vakser IA; Loew G; Waskell L Identification of the binding site on cytochrome P450 2B4 for cytochrome b(5) and cytochrome P450 reductase	44	20
1376	40	11465 1999 ANNUAL REVIEW OF ENTOMOLOGY 44():507-533 Feyereisen R Insect P450 enzymes	66	20
1377	19	11484 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 369(1):24-29 Graham SE; Peterson JA How similar are P450s and what can their differences teach us?	39	20
1378	7	11805 1999 NATURE 399(6737):670-673 Joo H; Lin ZL; Arnold FH Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation	99	20
1379	1	96 1960 CANCER RESEARCH 20(1):85-91 BOXER GE; SHONK CE LOW LEVELS OF SOLUBLE DPN-LINKED ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE IN TUMORS	124	19
1380	8	167 1962 BIOCHIMICA ET BIOPHYSICA ACTA 57(2):270-& BORST P AEROBIC OXIDATION OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE FORMED BY GLYCOLYSIS IN EHRLICH ASCITES-TUMOUR CELLS	61	19
1381	2	232 1963 FEDERATION PROCEEDINGS 22(4P1):1071-& ESTABROOK RW; GONZE J; NISSLEY SP A POSSIBLE ROLE FOR PYRIDINE NUCLEOTIDE IN COUPLING MECHANISM OF OXIDATIVE PHOSPHORYLATION	19	19
1382	2	263 1964 AMERICAN JOURNAL OF PHYSIOLOGY 207(6):1211-& CHAFFEE RRJ; CASSUTO Y; SMITH RE; ALLEN JR BIOCHEMISTRY OF BROWN FAT + LIVER OF COLD-ACCLIMATED HAMSTERS	65	19
1383	1	328 1964 JOURNAL OF CELL BIOLOGY 22(1):63-& FERNANDEZMORAN H; ODA T; GREEN DE; BLAIR PV MACROMOLECULAR REPEATING UNIT OF MITOCHONDRIAL STRUCTURE + FUNCTION - CORRELATED ELECTRON MICROSCOPIC + BIOCHEMICAL STUDIES ISOLATED MITOCHONDRIA + SUBMITOCHONDRIAL PARTICLES OF BEEF HEART MUSCLE	321	19
1384	4	364 1965 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 18(2):264-& TYLER DD; ESTABROOK RW ELECTRON AND ENERGY REQUIREMENTS FOR CYTOCHROME B REDUCTION DURING OXIDATION OF TETRAMETHYL-P-PHENYLENE DIAMINE	19	19
1385	1	588 1967 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 121(1):140-& MAITRA PK; ESTABROOK RW STUDIES OF BAKERS YEAST METABOLISM .3. OXIDATION OF ACETALDEHYDE	19	19
1386	7	790 1968 BIOCHEMICAL PHARMACOLOGY 17(9):1769-& GRAM TE; GUARINO AM; GREENE FE; GIGON PL; GILLETTE JR EFFECT OF PARTIAL HEPATECTOMY ON RESPONSIVENESS OF MICROSOMAL ENZYMES AND CYTOCHROME P-450 TO PHENOBARBITAL OR 3- METHYLCHOLANTHRENE	64	19
1387	5	883 1968 JOURNAL OF BIOLOGICAL CHEMISTRY 243(4):844-& PALMER G; HORGAN DJ; TISDALE H; SINGER TP; BEINERT H STUDIES ON RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE .14. LOCATION OF SITES OF INHIBITION OF ROTENONE BARBITURATES AND PIERICIDIN BY MEANS OF ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY	58	19
1388	4	966 1969 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 131(1):238-& DALY J; JERINA D; FARNSWOR.J; GUROFF G MIGRATION OF DEUTERIUM DURING ARYL HYDROXYLATION .2. EFFECT OF INDUCTION OF MICROSOMAL HYDROXYLASES WITH PHENOBARBITAL OR POLYCYCLIC AROMATIC HYDROCARBONS	45	19
1389	8	1203 1970 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 139(2):410-& BARON J; TEPHLY TR FURTHER STUDIES ON RELATIONSHIP OF STIMULATORY EFFECTS OF PHENOBARBITAL AND 3,4-BENZPYRENE ON HEPATIC HEME SYNTHESIS TO THEIR EFFECTS ON HEPATIC MICROSOMAL DRUG OXIDATIONS	80	19
1390	9	1247 1970 BIOCHEMISTRY 9(4):995-& HOLTZMAN JL EFFECT OF 4,4-DIDEUTERATION OF REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE ON MIXED FUNCTION OXIDASES OF HEPATIC MICROSOMES	27	19
1391	8	1298 1970 EUROPEAN JOURNAL OF BIOCHEMISTRY 14(2):317-& KUPFER D; ORRENIUS S INTERACTION OF DRUGS, STEROIDS AND FATTY ACIDS WITH LIVER- MICROSOMAL CYTOCHROME P-450	28	19
1392	4	1368 1970 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 173(2):233-& PETERS MA; FOUTS JR A STUDY OF SOME POSSIBLE MECHANISMS BY WHICH MAGNESIUM ACTIVATES HEPATIC MICROSOMAL DRUG METABOLISM IN-VITRO	47	19
1393	14	1405 1970 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 65(3):763-& GUTMAN M; SINGER TP; BEINERT H; CASIDA JE REACTION SITES OF ROTENONE, PIERICIDIN A, AND AMYTAL IN RELATION TO NONHEME IRON COMPONENTS OF NADH DEHYDROGENASE	60	19
1394	6	1428 1971 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 179(JUL6):155-& CONNEY AH; WELCH R; KUNTZMAN R; CHANG R; JACOBSON M; MUNROFAU.AD; PECK AW; BYE A; POLAND A; POPPERS PJ; FINSTER M; WOLFF JA EFFECTS OF ENVIRONMENTAL CHEMICALS ON METABOLISM OF DRUGS, CARCINOGENS, AND NORMAL BODY CONSTITUENTS IN MAN	104	19
1395	8	1588 1971 FEBS LETTERS 12(5):279-& JEFCOATE CR; BOYD GS PH-DEPENDENT CHANGES IN SPIN STATE OF CYTOCHROME P450 FROM ADRENAL MITOCHONDRIA	33	19
1396	4	1653 1971 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 176(3):766-& STRIPP B; HAMRICK ME; ZAMPAGLI.NG; GILLETTE JR EFFECT OF SPIRONOLACTONE ON DRUG METABOLISM BY HEPATIC MICROSOMES	87	19
1397	11	1755 1972 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 153(1):298-& WEST SB; LU AYH RECONSTITUTED LIVER MICROSOMAL ENZYME-SYSTEM THAT HYDROXYLATES DRUGS, OTHER FOREIGN COMPOUNDS AND ENDOGENOUS SUBSTRATES .5. COMPETITION BETWEEN CYTOCHROMES P-450 AND P-448 FOR REDUCTASE IN 3,4-BENZPYRENE HYDROXYLATION	31	19
1398	3	1774 1972 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 48(3):486-& PFEIFFER DR; TCHEN TT; KUO TH; CHAN SW; KIMURA T; CHU JW CHANGES IN SOME BIOCHEMICAL PARAMETERS INCLUDING CYTOCHROME-P- 450 AFTER HYPOPHYSECTOMY AND THEIR RESTORATION BY ACTH ADMINISTRATION IN RATS FOUR MONTHS POST HYPOPHYSECTOMY	28	19
1399	12	2125 1973 BIOCHEMISTRY 12(12):2309-2313 HOLTZMAN JL; RUMACK BH KINETIC STUDIES ON CONTROL OF ETHYLMORPHINE N-DEMETHYLASE - ROLE OF ETHYLMORPHINE ACTIVATION OF REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE-CYTOCHROME P-450 REDUCTASE	24	19
1400	6	2395 1974 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 162(1):83-92 KADLUBAR FF; ZIEGLER DM PROPERTIES OF A NADH-DEPENDENT N-HYDROXY AMINE REDUCTASE ISOLATED FROM PIG LIVER-MICROSOMES	55	19

#	Cited nodes	Nodes / Authors	GCS	LCS
1401	1	2844 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(2):747-751 ARGOS P; MATHEWS FS STRUCTURE OF FERROCYTOCHROME-B5 AT 2.8-A RESOLUTION	90	19
1402	9	2856 1975 JOURNAL OF BIOLOGICAL CHEMISTRY 250(20):7968-7972 YANG CS; STRICKHART FS INTERACTIONS BETWEEN SOLUBILIZED CYTOCHROME-P-450 AND HEPATIC MICROSOMES	33	19
1403	4	3074 1976 ENDOCRINOLOGY 99(4):977-987 ASANO K; HARDING BW BIOSYNTHESIS OF ADRENODOXIN IN MOUSE ADRENAL TUMOR-CELLS	28	19
1404	12	3082 1976 EUROPEAN JOURNAL OF BIOCHEMISTRY 66(1):139-146 RUF HH; NASTAINCZYK W BINDING OF A METYRAPONE SPIN LABEL TO MICROSOMAL CYTOCHROME-P- 450	44	19
1405	11	3127 1976 JOURNAL OF BIOLOGICAL CHEMISTRY 251(11):3213-3220 ARINC E; PHILPOT RM PREPARATION AND PROPERTIES OF PARTIALLY PURIFIED PULMONARY CYTOCHROME-P-450 FROM RABBITS	50	19
1406	7	3300 1977 BIOCHIMICA ET BIOPHYSICA ACTA 483(2):236-247 WATANUKI M; TILLEY BE; HALL PF PURIFICATION AND PROPERTIES OF CYTOCHROME-P-450 (11-BETA AND 18-HYDROXYLASE) FROM BOVINE ADRENOCORTICAL MITOCHONDRIA	61	19
1407	12	3391 1977 JOURNAL OF BIOLOGICAL CHEMISTRY 252(1):293-298 YANG CS INTERACTIONS BETWEEN SOLUBILIZED CYTOCHROME-P-450 AND HEPATIC MICROSOMES - CHARACTERIZATIONS OF BINDING AND ENHANCED CATALYTIC ACTIVITIES	42	19
1408	17	3627 1978 JOURNAL OF BIOLOGICAL CHEMISTRY 253(8):2804-2811 KUPFER D; NAVARRO J; PICCOLO DE HYDROXYLATION OF PROSTAGLANDINS-A1 AND E1 BY LIVER MICROSOMAL MONO-OXYGENASE - CHARACTERISTICS OF ENZYME-SYSTEM IN GUINEA-PIG	52	19
1409	21	3717 1979 ACTA BIOLOGICA ET MEDICA GERMANICA 38(2-3):163-175 WERRINGLOER J; KAWANO S; ESTABROOK RW SPIN STATE TRANSITIONS OF LIVER MICROSOMAL CYTOCHROME-P-450	19	19
1410	11	3744 1979 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 194(1):244-257 RAWITCH AB; TAUROG A; CHERNOFF SB; DORRIS ML HOG THYROID PEROXIDASE - PHYSICAL, CHEMICAL, AND CATALYTIC PROPERTIES OF THE HIGHLY PURIFIED ENZYME	87	19
1411	21	4127 1980 JOURNAL OF BIOCHEMISTRY 88(5):1521-1535 NOSHIRO M; HARADA N; OMURA T IMMUNOCHEMICAL STUDY ON THE ROUTE OF ELECTRON-TRANSFER FROM NADH AND NADPH TO CYTOCHROME-P-450 OF LIVER-MICROSOMES	33	19
1412	11	4527 1982 BIOCHEMICAL JOURNAL 207(1):51-56 PHILLIPSON CE; IOANNIDES C; DELAFORGE M; PARKE DV STUDIES ON THE SUBSTRATE-BINDING SITES OF LIVER MICROSOMAL CYTOCHROME P-448	43	19
1413	9	4549 1982 BIOCHEMISTRY 21(6):1331-1339 DEMONTELLANO PRO; KUNZE KL; BEILAN HS; WHEELER C DESTRUCTION OF CYTOCHROME-P-450 BY VINYL FLUORIDE, FLUROXENE, AND ACETYLENE - EVIDENCE FOR A RADICAL INTERMEDIATE IN OLEFIN OXIDATION	107	19
1414	16	5173 1984 JOURNAL OF BIOLOGICAL CHEMISTRY 259(6):3800-3804 WIKVALL K HYDROXYLATIONS IN BIOSYNTHESIS OF BILE-ACIDS - ISOLATION OF A CYTOCHROME-P-450 FROM RABBIT LIVER-MITOCHONDRIA CATALYZING 26- HYDROXYLATION OF C27-STEROIDS	87	19
1415	6	5223 1984 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81(7):1986-1990 WHITE PC; NEW MI; DUPONT B CLONING AND EXPRESSION OF CDNA-ENCODING A BOVINE ADRENAL CYTOCHROME-P-450 SPECIFIC FOR STEROID 21 HYDROXYLATION	90	19
1416	7	5285 1985 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 243(2):408-419 YEOWELL HN; LINKO P; HODGSON E; GOLDSTEIN JA INDUCTION OF SPECIFIC CYTOCHROME-P-450 ISOZYMES BY METHYLENEDIOXYPHENYL COMPOUNDS AND ANTAGONISM BY 3- METHYLCHOLANTHRENE	30	19
1417	13	5547 1986 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 251(1):336-347 WEISS RH; ESTABROOK RW THE MECHANISM OF CUMENE HYDROPEROXIDE-DEPENDENT LIPID- PEROXIDATION - THE SIGNIFICANCE OF OXYGEN-UPTAKE	19	19
1418	4	5779 1987 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 146(2):638-644 CAPDEVILA JH; KISHORE V; DISHMAN E; BLAIR IA; FALCK JR A NOVEL POOL OF RAT-LIVER INOSITOL AND ETHANOLAMINE PHOSPHOLIPIDS CONTAINS EPOXYEICOSATRIENOIC ACIDS (EETS)	32	19
1419	7	5912 1987 JOURNAL OF BIOLOGICAL CHEMISTRY 262(4):1542-1551 ATOR MA; DEMONTELLANO PRO PROTEIN CONTROL OF PROSTHETIC HEME REACTIVITY - REACTION OF SUBSTRATES WITH THE HEME EDGE OF HORSERADISH-PEROXIDASE	162	19
1420	5	5985 1987 TOXICOLOGY AND APPLIED PHARMACOLOGY 89(3):347-360 GOKSOYR A; ANDERSSON T; HANSSON T; KLUNGSOYR J; ZHANG Y; FORLIN L SPECIES CHARACTERISTICS OF THE HEPATIC XENOBIOTIC AND STEROID BIOTRANSFORMATION SYSTEMS OF 2 TELEOST FISH, ATLANTIC COD (GADUS-MORHUA) AND RAINBOW-TROUT (SALMO-GAIRDNERI)	70	19
1421	2	6023 1988 ANNALS OF HUMAN GENETICS 52():129-135 SANTISTEBAN I; POVEY S; SHEPHARD EA; PHILLIPS IR THE MAJOR PHENOBARBITAL-INDUCIBLE CYTOCHROME-P-450 GENE SUBFAMILY (P450IIB) MAPPED TO THE LONG ARM OF HUMAN CHROMOSOME- 19	26	19
1422	2	6284 1988 MOLECULAR PHARMACOLOGY 34(1):67-73 YANG HYL; NAMKUNG MJ; JUCHAU MR CYTOCHROME-P-450-DEPENDENT BIOTRANSFORMATION OF A SERIES OF PHENOXAZONE ETHERS IN THE RAT CONCEPTUS DURING EARLY ORGANOGENESIS - EVIDENCE FOR MULTIPLE P-450 ISOENZYMES	56	19
1423	7	6314 1988 SCIENCE 240(4859):1657-1659 RODGERS KK; POCHAPSKY TC; SLIGAR SG PROBING THE MECHANISMS OF MACROMOLECULAR RECOGNITION - THE CYTOCHROME-B5-CYTOCHROME-C COMPLEX	109	19
1424	11	6368 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 268(2):567-575 YAMAZOE Y; MURAYAMA N; SHIMADA M; YAMAUCHI K; KATO R CYTOCHROME-P450 IN LIVERS OF DIABETIC RATS - REGULATION BY GROWTH-HORMONE AND INSULIN	67	19
1425	5	6398 1989 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 275(2):429-439 TRETIAKOV VE; DEGTYARENKO KN; UVAROV VY; ARCHAKOV AI SECONDARY STRUCTURE AND MEMBRANE TOPOLOGY OF CYTOCHROME-P450S	28	19
1426	3	6413 1989 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 162(1):265-272 FUKUHARA M; NAGATA K; MIZOKAMI K; YAMAZOE Y; TAKANAKA A; KATO R COMPLETE CDNA SEQUENCE OF A MAJOR 3-METHYLCHOLANTHRENE- INDUCIBLE CYTOCHROME-P-450 ISOZYME (P-450AFB) OF SYRIAN- HAMSTERS WITH HIGH-ACTIVITY TOWARD AFLATOXIN-B1	30	19
1427	9	6424 1989 BIOCHEMICAL JOURNAL 262(1):151-158 BARS RG; MITCHELL AM; WOLF CR; ELCOMBE CR INDUCTION OF CYTOCHROME-P-450 IN CULTURED RAT HEPATOCYTES - THE HETEROGENEOUS LOCALIZATION OF SPECIFIC ISOENZYMES USING IMMUNOCYTOCHEMISTRY	50	19
1428	5	6607 1989 GENE 83(1):15-24 POMPON D; NICOLAS A PROTEIN ENGINEERING BY CDNA RECOMBINATION IN YEASTS - SHUFFLING OF MAMMALIAN CYTOCHROME-P-450 FUNCTIONS	59	19
1429	2	6644 1989 JOURNAL OF BIOLOGICAL CHEMISTRY 264(28):16478-16482 DENISON MS; FISHER JM; WHITLOCK JP PROTEIN-DNA INTERACTIONS AT RECOGNITION SITES FOR THE DIOXIN-AH RECEPTOR COMPLEX	132	19
1430	9	6858 1990 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 172(2):737-744 EUGSTER HP; SENGSTAG C; MEYER UA; HINNEN A; WURGLER FE CONSTITUTIVE AND INDUCIBLE EXPRESSION OF HUMAN CYTOCHROME- P450IA1 IN YEAST SACCHAROMYCES-CEREVISIAE - AN ALTERNATIVE ENZYME SOURCE FOR INVITRO STUDIES	44	19
1431	7	6863 1990 BIOCHEMICAL JOURNAL 266(2):497-504 EDWARDS RJ; SINGLETON AM; MURRAY BP; SESARDIC D; RICH KJ; DAVIES DS; BOOBIS AR AN ANTIPEPTIDE ANTIBODY TARGETED TO A SPECIFIC REGION OF RAT CYTOCHROME P-450IA2 INHIBITS ENZYME-ACTIVITY	35	19
1432	18	6965 1990 CANCER RESEARCH 50(7):2036-2043 SHIMADA T; GUENGERICH FP INACTIVATION OF 1,3-DINITROPYRENE, 1,6-DINITROPYRENE, AND 1,8- DINITROPYRENE BY CYTOCHROME-P-450 ENZYMES IN HUMAN AND RAT- LIVER MICROSOMES	36	19
1433	1	7040 1990 EMBO JOURNAL 9(1):69-76 WILHELMSSON A; CUTHILL S; DENIS M; WIKSTROM AC; GUSTAFSSON JA; POELLINGER L THE SPECIFIC DNA-BINDING ACTIVITY OF THE DIOXIN RECEPTOR IS MODULATED BY THE 90 KD HEAT-SHOCK PROTEIN	157	19
1434	9	7055 1990 EUROPEAN JOURNAL OF BIOCHEMISTRY 187(1):23-29 YOKOTANI N; SOGAWA K; MATSUBARA S; GOTOH O; KUSUNOSE E; KUSUNOSE M; FUJIIKURIYAMA Y CDNA CLONING OF CYTOCHROME-P-450 RELATED TO P-450P-2 FROM THE CDNA LIBRARY OF HUMAN-PLACENTA - GENE STRUCTURE AND EXPRESSION	23	19
1435	15	7133 1990 JOURNAL OF BIOLOGICAL CHEMISTRY 265(11):6066-6073 PETERSON JA; LORENCE MC; AMARNEH B PUTIDAREDOXIN REDUCTASE AND PUTIDAREDOXIN - CLONING, SEQUENCE DETERMINATION, AND HETEROLOGOUS EXPRESSION OF THE PROTEINS	80	19
1436	3	7222 1990 MOLECULAR AND CELLULAR BIOLOGY 10(9):4495-4505 UENO T; GONZALEZ FJ TRANSCRIPTIONAL CONTROL OF THE RAT HEPATIC CYP2E1 GENE	61	19
1437	19	7449 1991 BIOCHIMICA ET BIOPHYSICA ACTA 1074(1):209-213 IMAOKA S; FUNAE Y HEPATIC AND RENAL CYTOCHROME-P-450S IN SPONTANEOUSLY HYPERTENSIVE RATS	30	19
1438	15	7485 1991 CANCER RESEARCH 51(19):5284-5291 SHIMADA T; GUENGERICH FP ACTIVATION OF AMINO-ALPHA-CARBOLINE, 2-AMINO-1-METHYL-6- PHENYLIMIDAZO[4,5-B]PYRIDINE, AND A COPPER PHTHALOCYANINE CELLULOSE EXTRACT OF CIGARETTE-SMOKE CONDENSATE BY CYTOCHROME- P-450 ENZYMES IN RAT AND HUMAN LIVER-MICROSOMES	58	19
1439	11	7516 1991 CRITICAL REVIEWS IN TOXICOLOGY 21(5):345-372 DAHL AR; HADLEY WM NASAL CAVITY ENZYMES INVOLVED IN XENOBIOTIC METABOLISM - EFFECTS ON THE TOXICITY OF INHALANTS	110	19
1440	6	7565 1991 EUROPEAN JOURNAL OF BIOCHEMISTRY 202(2):583-588 TRELUYER JM; JACQZAIGRAIN E; ALVAREZ F; CRESTEIL T EXPRESSION OF CYP2D6 IN DEVELOPING HUMAN LIVER	58	19
1441	8	7580 1991 FISH PHYSIOLOGY AND BIOCHEMISTRY 9(3):189-197 CELANDER M; FORLIN L CATALYTIC ACTIVITY AND IMMUNOCHEMICAL QUANTIFICATION OF HEPATIC CYTOCHROME-P-450 IN BETA-NAPHTHOFLAVONE AND ISOSAFROL TREATED RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)	52	19
1442	11	7962 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1130(3):329-332 YANAGIMOTO T; ITOH S; MULLERENOCH D; KAMATAKI T MOUSE-LIVER CYTOCHROME-P-450 (P-450IIIAM1) - ITS CDNA CLONING AND INDUCIBILITY BY DEXAMETHASONE	44	19
1443	13	7969 1992 BIOCHIMICA ET BIOPHYSICA ACTA 1156(1):43-49 WINTERS DK; CEDERBAUM AI EXPRESSION OF A CATALYTICALLY ACTIVE HUMAN CYTOCHROME P-4502E1 IN ESCHERICHIA-COLI	22	19
1444	6	8102 1992 FASEB JOURNAL 6(2):706-710 FUJIIKURIYAMA Y; IMATAKA H; SOGAWA K; YASUMOTO KI; KIKUCHI Y REGULATION OF CYP1A1 EXPRESSION	77	19
1445	13	8124 1992 GASTROENTEROLOGY 102(4):1186-1198 KOLARS JC; SCHMIEDLINREN P; DOBBINS WO; SCHUETZ J; WRIGHTON SA; WATKINS PB HETEROGENEITY OF CYTOCHROME-P450IIIA EXPRESSION IN RAT GUT EPITHELIA	55	19
1446	10	8127 1992 GENOMICS 14(1):49-58 HEIM MH; MEYER UA EVOLUTION OF A HIGHLY POLYMORPHIC HUMAN CYTOCHROME P450 GENE- CLUSTER - CYP2D6	76	19
1447	5	8155 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(2):789-793 OHASHI K; RUAN KH; KULMACZ RJ; WU KK; WANG LH PRIMARY STRUCTURE OF HUMAN THROMBOXANE SYNTHASE DETERMINED FROM THE CDNA SEQUENCE	82	19
1448	16	8164 1992 JOURNAL OF BIOLOGICAL CHEMISTRY 267(8):5614-5620 TUCK SF; PETERSON JA; DEMONTELLANO PRO ACTIVE-SITE TOPOLOGIES OF BACTERIAL CYTOCHROME-P450101 (P450CAM), CYTOCHROME-P450108 (P450TERP), AND CYTOCHROME- P450102 (P450BM-3) - INSITU REARRANGEMENT OF THEIR PHENYL-IRON COMPLEXES	29	19
1449	33	8288 1992 MUTATION RESEARCH 277(3):251-275 LANGENBACH R; SMITH PB; CRESPI C RECOMBINANT-DNA APPROACHES FOR THE DEVELOPMENT OF METABOLIC SYSTEMS USED IN INVITRO TOXICOLOGY	41	19
1450	15	8376 1993 ANESTHESIOLOGY 79(4):795-807 KHARASCH ED; THUMMEL KE IDENTIFICATION OF CYTOCHROME-P450 2E1 AS THE PREDOMINANT ENZYME CATALYZING HUMAN LIVER MICROSOMAL DEFLUORINATION OF SEVOFLURANE, ISOFLURANE, AND METHOXYFLURANE	140	19
1451	15	8389 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 300(1):18-23 CHEN LP; HARDWICK JP IDENTIFICATION OF A NEW P450 SUBFAMILY, CYP4F1, EXPRESSED IN RAT HEPATIC-TUMORS	39	19
1452	19	8403 1993 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 304(1):257-265 SHEN SJ; STROBEL HW ROLE OF LYSINE AND ARGININE RESIDUES OF CYTOCHROME-P450 IN THE INTERACTION BETWEEN CYTOCHROME-P4502B1 AND NADPH-CYTOCHROME P450 REDUCTASE	36	19
1453	5	8497 1993 BIOCHEMISTRY 32(38):9875-9880 MCMILLAN K; MASTERS BSS OPTICAL-DIFFERENCE SPECTROPHOTOMETRY AS A PROBE OF RAT-BRAIN NITRIC-OXIDE SYNTHASE HEME-SUBSTRATE INTERACTION	122	19
1454	33	8547 1993 CARCINOGENESIS 14(4):585-592 MURRAY BP; EDWARDS RJ; MURRAY S; SINGLETON AM; DAVIES DS; BOOBIS AR HUMAN HEPATIC CYP1A1 AND CYP1A2 CONTENT, DETERMINED WITH SPECIFIC ANTIPEPTIDE ANTIBODIES, CORRELATES WITH THE MUTAGENIC ACTIVATION OF PHIP	51	19
1455	6	8734 1993 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 266(1):52-59 CHIBA K; KOBAYASHI K; MANABE K; TANI M; KAMATAKI T; ISHIZAKI T OXIDATIVE-METABOLISM OF OMEPRAZOLE IN HUMAN LIVER-MICROSOMES - COSEGREGATION WITH S-MEPHENYTOIN 4'-HYDROXYLATION	102	19
1456	6	8830 1993 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90(10):4552-4556 CURNOW KM; SLUTSKER L; VITEK J; COLE T; SPEISER PW; NEW MI; WHITE PC; PASCOE L MUTATIONS IN THE CYP11B1 GENE CAUSING CONGENITAL ADRENAL- HYPERPLASIA AND HYPERTENSION CLUSTER IN EXON-6, EXON-7, AND EXON-8	78	19
1457	9	8944 1994 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 201(3):1320-1326 AOYAMA Y; FUNAE Y; NOSHIRO M; HORIUCHI T; YOSHIDA Y OCCURRENCE OF A P450 SHOWING HIGH HOMOLOGY TO YEAST LANOSTEROL 14-DEMETHYLASE (P450(14DM)) IN THE RAT-LIVER	43	19
1458	17	9207 1994 JOURNAL OF BIOLOGICAL CHEMISTRY 269(45):27783-27786 WATERMAN MR BIOCHEMICAL DIVERSITY OF CAMP-DEPENDENT TRANSCRIPTION OF STEROID HYDROXYLASE GENES IN THE ADRENAL-CORTEX	81	19
1459	8	9341 1994 PLANT PHYSIOLOGY 106(1):17-23 SHIOTA N; NAGASAWA A; SAKAKI T; YABUSAKI Y; OHKAWA H HERBICIDE-RESISTANT TOBACCO PLANTS EXPRESSING THE FUSED ENZYME BETWEEN RAT CYTOCHROME P4501A1 (CYP1A1) AND YEAST NADPH- CYTOCHROME P450 OXIDOREDUCTASE	41	19
1460	24	9450 1995 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 321(2):277-288 KEMPF AC; ZANGER UM; MEYER UA TRUNCATED HUMAN P450 2D6 - EXPRESSION IN ESCHERICHIA-COLI, NI2+-CHELATE AFFINITY PURIFICATION, AND CHARACTERIZATION OF SOLUBILITY AND AGGREGATION	31	19
1461	19	9504 1995 BIOCHEMICAL PHARMACOLOGY 50(11):1775-1782 Amet Y; Berthou F; Baird S; Dreano Y; Bail JP; Menez JF Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1	24	19
1462	14	9719 1995 JOURNAL OF BIOLOGICAL CHEMISTRY 270(10):5014-5018 KOLEY AP; BUTERS JTM; ROBINSON RC; MARKOWITZ A; FRIEDMAN FK CO BINDING-KINETICS OF HUMAN CYTOCHROME-P450 3A4 - SPECIFIC INTERACTION OF SUBSTRATES WITH KINETICALLY DISTINGUISHABLE CONFORMERS	46	19
1463	17	9731 1995 JOURNAL OF BIOLOGICAL CHEMISTRY 270(50):29739-29745 STAPLETON G; STEEL M; RICHARDSON M; MASON JO; ROSE KA; MORRIS RGM; LATHE R A NOVEL CYTOCHROME-P450 EXPRESSED PRIMARILY IN BRAIN	62	19
1464	19	9840 1995 PHARMACOGENETICS 5(3):143-150 ONO S; HATANAKA T; HOTTA H; TSUTSUI M; SATOH T; GONZALEZ FJ CHLORZOXAZONE IS METABOLIZED BY HUMAN CYP1A2 AS WELL AS BY HUMAN CYP2E1	76	19
1465	11	9848 1995 PHARMACOTHERAPY 15(6):S84-S99 RIESENMAN C ANTIDEPRESSANT DRUG-INTERACTIONS AND THE CYTOCHROME-P450 SYSTEM - A CRITICAL-APPRAISAL	49	19
1466	10	9857 1995 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92(6):2071-2075 KRAUS PFX; KUTCHAN TM MOLECULAR-CLONING AND HETEROLOGOUS EXPRESSION OF A CDNA- ENCODING BERBAMUNINE SYNTHASE, A C-O PHENOL-COUPLING CYTOCHROME-P450 FROM THE HIGHER-PLANT BERBERIS-STOLONIFERA	46	19
1467	14	9950 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 327(2):254-259 Dong JS; Porter TD Coexpression of mammalian cytochrome P450 and reductase in Escherichia coli	22	19
1468	34	9962 1996 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 330(1):48-58 Chun YJ; Shimada T; Guengerich FP Construction of a human cytochrome P450 1A1:Rat NADPH- cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification	20	19
1469	7	10003 1996 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 221(2):318-322 IngelmanSundberg M; Hagbjork AL; Ueng YF; Yamazaki H; Guengerich FP High rates of substrate hydroxylation by human cytochrome p450 3A4 in reconstituted membranous vesicles: Influence of membrane charge	26	19
1470	13	10004 1996 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 221(2):466-470 Jounaidi Y; Hyrailles V; Gervot L; Maurel P Detection of a CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein?	35	19
1471	15	10059 1996 BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1299(2):267-277 Rosolowsky M; Campbell WB Synthesis of hydroxyeicosatetraenoic (HETEs) and epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells	63	19
1472	5	10095 1996 CELL 85(2):171-182 Szekeres M; Nemeth K; KonczKalman Z; Mathur J; Kauschmann A; Altmann T; Redei GP; Nagy F; Schell J; Koncz C Brassinosteroids rescue the deficiency of CYP90, a cytochrome P450, controlling cell elongation and de-etiolation in arabidopsis	243	19
1473	43	10106 1996 CHEMICAL REVIEWS 96(7):2841-2887 Sono M; Roach MP; Coulter ED; Dawson JH Heme-containing oxygenases	378	19
1474	22	10129 1996 CYTOCHROME P450, PT B 272():3-14 Barnes HJ Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli	33	19
1475	27	10241 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(21):12496-12501 Ibeanu GC; Ghanayem BI; Linko P; Li LP; Pedersen LG; Goldstein JA Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole hydroxylase activity	41	19
1476	22	10247 1996 JOURNAL OF BIOLOGICAL CHEMISTRY 271(37):22462-22469 Sibbesen O; DeVoss JJ; deMontellano PRO Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein - Construction of a self-sufficient Escherichia coli catalytic system	25	19
1477	15	10414 1996 TOXICOLOGIC PATHOLOGY 24(1):45-57 Parkinson A An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials	78	19
1478	21	10984 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):111-120 Shimada T; Wunsch RM; Hanna IH; Sutter TR; Guengerich FP; Gillam EMJ Recombinant human cytochrome P450 1B1 expression in Escherichia coli	38	19
1479	38	11035 1998 BIOCHEMICAL PHARMACOLOGY 56(3):377-387 Edwards RJ; Adams DA; Watts PS; Davies DS; Boobis AR Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans	45	19
1480	41	11084 1998 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 45(6):525-538 Miners JO; Birkett DJ Cytochrome P4502C9: an enzyme of major importance in human drug metabolism	143	19
1481	2	84 1960 BIOCHEMICAL JOURNAL 76():179-189 HOLTON FA; COLPABOONSTRA J SPECTROPHOTOMETRIC OBSERVATIONS RELATING TO THE OXIDATION- REDUCTION POTENTIAL OF CYTOCHROME-B IN NON-PHOSPHORYLATING HEART-MUSCLE PARTICLES	32	18
1482	1	183 1962 JOURNAL OF BIOLOGICAL CHEMISTRY 237(8):2670-& VASINGTON FD; MURPHY JV CA++ UPTAKE BY RAT KIDNEY MITOCHONDRIA AND ITS DEPENDENCE ON RESPIRATION AND PHOSPHORYLATION	407	18
1483	3	471 1966 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 24(1):1-& BAUM H; RIESKE JS INVOLVEMENT OF WATER IN ELECTRON TRANSPORT IN COMPLESES 3 AND 4 OF MITOCHONDRIAL ELECTRON TRANSPORT CHAIN	41	18
1484	3	491 1966 BIOCHIMICA ET BIOPHYSICA ACTA 117(2):450-& PERON FG; MCCARTHY JL; GUERRA F FURTHER STUDIES ON CORTICOSTEROIDOGENESIS .4. INHIBITION OF UTILIZATION OF BIOLOGICAL SUBSTRATES FOR CORTICOID SYNTHESIS BY HIGH CALCIUM CONCENTRATIONS . POSSIBLE ROLE OF TRANSHYDROGENASE IN CORTICOSTEROIDOGENESIS	47	18
1485	1	545 1966 JOURNAL OF BIOLOGICAL CHEMISTRY 241(22):5366-& JICK H; SHUSTER L TURNOVER OF MICROSOMAL REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE-CYTOCHROME C REDUCTASE IN LIVERS OF MICE TREATED WITH PHENOBARBITAL	117	18
1486	5	571 1966 STEROIDS 8(6):929-& SANZARI NP; PERON FG INFLUENCE OF METOPIRONE ON SUBSTRATE-SUPPORTED HYDROXYLATION OF DOC BY RAT ADRENAL MITOCHONDRIA	37	18
1487	5	629 1967 BIOCHEMISTRY 6(4):1021-& HOSOYA T; MORRISON M A STUDY OF HEMOPROTEINS OF THYROID MICROSOMES WITH EMPHASIS ON THYROID PEROXIDASE	63	18
1488	7	694 1967 JOURNAL OF BIOLOGICAL CHEMISTRY 242(22):5169-& HINKLE PC; BUTOW RA; RACKER E; CHANCE B PARTIAL RESOLUTION OF ENZYMES CATALYZING OXIDATIVE PHOSPHORYLATION .15. REVERSE ELECTRON TRANSFER IN FLAVIN- CYTOCHROME B REGION OF RESPIRATORY CHAIN OF BEEF HEART SUBMITOCHONDRIAL PARTICLES	56	18
1489	5	764 1968 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 126(1):320-& POE M; ESTABROOK RW KINETIC STUDIES OF TEMPERATURE CHANGES AND OXYGEN UPTAKE CONCOMITANT WITH SUBSTRATE OXIDATION BY MITOCHONDRIA - ENTHALPY OF SUCCINATE OXIDATION DURING ATP FORMATION BY MITOCHONDRIA	18	18
1490	3	856 1968 HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 349(11):1621-& REMMER H INDUCTION OF MICROSOMAL HYDROXYLASE - INVOLVEMENT OF A SECOND FACTOR BESIDES CYTOCHROME P-450	15	18
1491	3	963 1969 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 130(1-2):66-& SWEAT ML; YOUNG RB; BRYSON MJ STUDEIS OF OXIDATION STATE OF PARTIALLY PURIFIED ADRENAL CORTEX MITOCHONDRIAL CYTOCHROME P-450 AND DIFFERENCE SPECTRA INDUCED BY DEOXYCORTICOSTERONE AND METOPIRONE	19	18
1492	13	1066 1969 EUROPEAN JOURNAL OF BIOCHEMISTRY 9(3):299-& ERNSTER L; LEE IY; NORLING B; PERSSON B STUDIES WITH UBIQUINONE-DEPLETED SUBMITOCHONDRIAL PARTICLES - ESSENTIALITY OF UBIQUINONE FOR INTERACTION OF SUCCINATE DEHYDROGENASE, NADH DEHYDROGENASE, AND CYTOCHROME B	170	18
1493	11	1256 1970 BIOCHEMISTRY 9(19):3816-& JEFCOATE CR; GAYLOR JL LIGAND INTERACTIONS WITH HEMOPROTEIN-P-450 - EQUILIBRIA BETWEEN HIGH-SPIN AND LOW-SPIN FORMS OF P-450 IN BOVINE ADRENAL MITOCHONDRIA	23	18
1494	10	1372 1970 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 175(1):12-& GRAM TE; GUARINO AM; SCHROEDE.DH; DAVIS DC; REAGAN RL; GILLETTE JR EFFECT OF STARVATION ON KINETICS OF DRUG OXIDATION BY HEPATIC MICROSOMAL ENZYMES FROM MALE AND FEMALE RATS	59	18
1495	7	1541 1971 BIOCHIMICA ET BIOPHYSICA ACTA 253(1):88-& SATO N; WILSON DF; CHANCE B SPECTRAL PROPERTIES OF B CYTOCHROMES IN INTACT MITOCHONDRIA	78	18
1496	8	1675 1971 MOLECULAR PHARMACOLOGY 7(6):683-& GLAZER RI; SCHENKMAN JB; SARTOREL.AC IMMUNOCHEMICAL STUDIES ON ROLE OF REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE-CYTOCHROME-C (P-450) REDUCTASE IN DRUG OXIDATION	39	18
1497	11	1802 1972 BIOCHEMICAL PHARMACOLOGY 21(21):2887-& NORRED WP; WADE AE DIETARY FATTY ACID-INDUCED ALTERATIONS OF HEPATIC MICROSOMAL DRUG-METABOLISM	155	18
1498	10	2016 1972 TOXICOLOGY AND APPLIED PHARMACOLOGY 23(4):541-552 CASTRO JA; GOMEZ MID STUDIES ON IRREVERSIBLE BINDING OF C-14-CCI4 TO MICROSOMAL LIPIDS IN RATS UNDER VARYING EXPERIMENTAL CONDITIONS	76	18
1499	1	2227 1973 EUROPEAN JOURNAL OF BIOCHEMISTRY 36(1):201-212 BJORKHEM I; GUSTAFSS.J OMEGA-HYDROXYLATION OF STEROID SIDE-CHAIN IN BIOSYNTHESIS OF BILE-ACIDS	131	18
1500	11	2526 1974 FEBS LETTERS 38(3):337-340 BALLOU DP; VEEGER C; VANDERHO.TA; COON MJ PROPERTIES OF PARTIALLY PURIFIED LIVER MICROSOMAL CYTOCHROME-P- 450 - ACCEPTANCE OF 2 ELECTRONS DURING AN AEROBIC TITRATION	26	18

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