#	Cited nodes	Nodes / Authors	GCS	LCS
12601	2	12436 2001 DRUG AND CHEMICAL TOXICOLOGY 24(4):429-437 Ebrahim AS; Babu E; Thirunavukkarasu C; Sakthisekaran D Protective role of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced alterations in ATPases	0	0
12602	1	12446 2001 DRUG METABOLISM AND DISPOSITION 29(6):779-780 Murphy PJ Xenobiotic metabolism: A look from the past to the future	0	0
12603	21	12448 2001 DRUG METABOLISM AND DISPOSITION 29(6):837-842 Turan VK; Mishin VM; Thomas PE Clotrimazole is a selective and potent inhibitor of rat cytochrome P450 3A subfamily-related testosterone metabolism	0	0
12604	11	12449 2001 DRUG METABOLISM AND DISPOSITION 29(6):908-915 Myers MJ; Farrell DE; Howard KD; Kawalek JC Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine	5	0
12605	17	12450 2001 DRUG METABOLISM AND DISPOSITION 29(7):983-989 Fujita K; Kamataki T Screening of organosulfur compounds as inhibitors of human CYP2A6	2	0
12606	9	12452 2001 DRUG METABOLISM AND DISPOSITION 29(8):1146-1155 Subrahmanyam V; Renwick AB; Walters DG; Young PJ; Price RJ; Tonelli AP; Lake BG Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes	3	0
12607	7	12454 2001 DRUG METABOLISM AND DISPOSITION 29(11):1403-1409 Kuperman AV; Kalgutkar AS; Marfat A; Chambers RJ; Liston TE Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: In vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue	2	0
12608	15	12455 2001 DRUG METABOLISM AND DISPOSITION 29(11):1499-1504 El-Sankary W; Gibson GG; Ayrton A; Plant N Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers	7	0
12609	10	12456 2001 DRUG METABOLISM REVIEWS 33(1):1-35 Miller KP; Ramos KS Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons	7	0
12610	17	12457 2001 DRUG METABOLISM REVIEWS 33(1):81-116 Mannering GJ A life in science: Biochemist-nutritionist-forensic toxicologst-pharmacologist	0	0
12611	6	12458 2001 DRUG METABOLISM REVIEWS 33(3-4):255-271 Kong ANT; Owuor E; Yu R; Hebbar V; Chen C; Hu R; Mandlekar S Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)	14	0
12612	25	12459 2001 EMBO JOURNAL 20(10):2394-2403 Anandatheerthavarada HK; Amuthan G; Biswas G; Robin MA; Murali R; Waterman MR; Avadhani NG Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points	1	0
12613	17	12460 2001 ENDOCRINOLOGY 142(6):2569-2576 Huang MC; Miller WL Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system	1	0
12614	4	12463 2001 ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 30(1):1-+ New MI Prenatal treatment of congenital adrenal hyperplasia - The United States experience	3	0
12615	2	12469 2001 EUROPEAN HEART JOURNAL 22(16):1374-1450 Priori SG; Aliot E; Blomstrom-Lundqvist C; Bossaert L; Breithardt G; Brugada P; Camm AJ; Cappato R; Cobbe SM; Di Mario C; Maron BJ; McKenna WJ; Pedersen AK; Ravens U; Schwartz PJ; Trusz-Gluza M; Vardas P; Wellens HJJ; Zipes DP Task force on sudden cardiac death of the European Society of Cardiology	28	0
12616	3	12470 2001 EUROPEAN HEART JOURNAL SUPPLEMENTS 3(K):K93-K100 Bauman JL The role of pharmacokinetics, drug interactions and pharmacogenetics in the acquired long QT syndrome	2	0
12617	9	12471 2001 EUROPEAN JOURNAL OF BIOCHEMISTRY 268(5):1448-1459 Gomez-Lechon MJ; Donato T; Jover R; Rodriguez C; Ponsoda X; Glaise D; Castell JV; Guguen-Guillouzo C Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2	6	0
12618	10	12472 2001 EUROPEAN JOURNAL OF BIOCHEMISTRY 268(10):3083-3090 Le Bouquin R; Skrabs M; Kahn R; Benveniste I; Salaun JP; Schreiber L; Durst F; Pinot F CYP94A5, a new cytochrome P450 from Nicotiana tabacum is able to catalyze the oxidation of fatty acids to the omega-alcohol and to the corresponding diacid	2	0
12619	16	12477 2001 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 31(10):880-886 Finnstrom N; Bjelfman C; Soderstrom TG; Smith G; Egevad L; Norlen BJ; Wolf CR; Rane A Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR	2	0
12620	4	12479 2001 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 26(1-2):31-35 Klinger W; Karge E; Demme U; Kretzschmar M Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment	0	0
12621	21	12480 2001 EUROPEAN RESPIRATORY JOURNAL 18():122S-126S Hukkanen J; Pelkonen O; Raunio H Expression of xenobiotic-metabolizing enzymes in human pulmonary tissue: possible role in susceptibility for ILD	2	0
12622	4	12481 2001 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 52(6):513-522 Klinger W; Lupp A; Barth A; Karge E; Knels L; Kuhn U; Muller D; Schiller F; Demme U; Lindstrom-Seppa P; Hanninen O Cytochrome P450 (P450) isoforms expression, P450 concentration, monooxygenase activities, reactive oxygen species formation, lipid peroxidation, and glutathione content in wild catch carp and tench liver - influence of a two weeks exposure to phenobarbital	0	0
12623	8	12483 2001 FARADAY DISCUSSIONS 120():261-276 Dano S; Hynne F; De Monte S; d'Ovidio F; Sorensen PG; Westerhoff H Synchronization of glycolytic oscillations in a yeast cell population	0	0
12624	2	12484 2001 FEMS MICROBIOLOGY LETTERS 198(1):23-29 Maitra PK; Bhosale SB; Kshirsagar DC; Yeole TY; Shanbhag AN Metabolite and enzyme profiles of glycogen metabolism in Methanococcoides methylutens	2	0
12625	6	12485 2001 FERTILITY AND STERILITY 76(3):517-524 Attia GR; Rainey WE; Carr BR Metformin directly inhibits androgen production in human thecal cells	8	0
12626	6	12486 2001 FOLIA HISTOCHEMICA ET CYTOBIOLOGICA 39():48-49 Testai E The relevance of xenobiotic metabolism in the interindividual susceptibility to chemicals	0	0
12627	16	12487 2001 FOOD AND CHEMICAL TOXICOLOGY 39(2):125-132 Hannon-Fletcher MPA; O'Kane MJ; Moles KW; Barnett YA; Barnett CR Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects	6	0
12628	7	12488 2001 FOOD AND CHEMICAL TOXICOLOGY 39(7):667-680 Walton K; Dorne JL; Renwick AG Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates	9	0
12629	1	12491 2001 GASTROENTEROLOGY 120(2):525-533 Kullak-Ublick GA; Ismair MG; Stieger B; Landmann L; Huber R; Pizzagalli F; Fattinger K; Meier PJ; Hagenbuch B Organic anion-transporting potypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver	63	0
12630	7	12494 2001 GENOME RESEARCH 11(5):685-702 Glusman G; Yanai I; Rubin I; Lancet D The complete human olfactory subgenome	69	0
12631	12	12497 2001 HISTOCHEMICAL JOURNAL 33(2):101-110 Sarasquete C; Ortiz JB; Gisbert E Immunohistochemical distribution of cytochrome P4501A in larvae and fingerlings of the Siberian sturgeon, Acipenser baeri	1	0
12632	6	12498 2001 HUMAN AND ECOLOGICAL RISK ASSESSMENT 7(1):181-201 Walton K; Dorne JLCM; Renwick AG Default factors for interspecies differences in the major routes of xenobiotic elimination	3	0
12633	16	12500 2001 IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 37(3):180-184 Sadar MD; Andersson TB Regulation of cytochrome P450 in a primary culture of rainbow trout hepatocytes	0	0
12634	14	12501 2001 IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT 37(5):622-628 Canto-Canche BB; Loyola-Vargas VM Multiple forms of NADPH-cytochrome P450 oxidoreductases in the Madagascar periwinkle Catharanthus roseus	1	0
12635	11	12504 2001 INSECT MOLECULAR BIOLOGY 10(3):191-196 Kasai S; Scott JG Cytochrome P450s CYP6D3 and CYP6D1 are part of a P450 gene cluster on autosome 1 in the house fly	2	0
12636	5	12505 2001 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 33(6):603-612 Ding J; Ichikawa M; Furukawa A; Tomita S; Tanaka K; Ichikawa Y Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts	2	0
12637	3	12507 2001 INVESTIGATIONAL NEW DRUGS 19(2):155-162 Malingre MM; Beijnen JH; Schellens JHM Oral delivery of taxanes	10	0
12638	9	12508 2001 IUBMB LIFE 52(3-5):129-134 Vinogradov AD; Grivennikova VG The mitochondrial complex I: Progress in understanding of catalytic properties	7	0
12639	2	12509 2001 JAPANESE JOURNAL OF CANCER RESEARCH 92(6):610-616 Tanuma J; Fujii K; Hirano M; Matsuuchi H; Shisa H; Hiai H; Kitano H Five quantitative trait loci affecting 4-nitroquinoline 1- oxide-induced tongue cancer in the rat	2	0
12640	5	12512 2001 JOURNAL OF BIOCHEMISTRY 129(5):709-716 Yubisui T; Takahashi F; Takabayashi T; Fujiwara S; Kawamura K Characterization of cytochrome b(5) in the ascidian Polyandrocarpa misakiensis and budding-specific expression	1	0
12641	5	12514 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(6):4315-4321 Bai JX; Cederbaum AI Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells	12	0
12642	20	12524 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(33):31459-31465 Nakayama K; Puchkaev A; Pikuleva IA Membrane binding and substrate access merge in cytochrome P4507Al, a key enzyme in degradation of cholesterol	7	0
12643	47	12525 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(39):36059-36062 Zeldin DC Epoxygenase pathways of arachidonic acid metabolism	19	0
12644	10	12526 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(39):36261-36267 Tomita T; Ogo S; Egawa T; Shimada H; Okamoto N; Imai Y; Watanabe Y; Ishimura Y; Kitagawa T Elucidation of the differences between the 430-and 455-nm absorbing forms of P450-isocyanide adducts by resonance Raman spectroscopy	0	0
12645	17	12527 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(41):38010-38022 Saito T; Takahashi Y; Hashimoto H; Kamataki T Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element	7	0
12646	5	12531 2001 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 19(2):273-277 Buchatskii AG; Kazachenko KY; Alexandrov AA Cytochrome P450 pattern revision	0	0
12647	4	12532 2001 JOURNAL OF BIOSCIENCE AND BIOENGINEERING 92(6):580-584 Uzura A; Suzuki T; Katsuragi T; Tani Y Involvement of cytochrome P450 in hydroxylation of propylbenzene by Fusarium moniliforme strain MS31	0	0
12648	13	12535 2001 JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 76(3):237-244 Lewis DFV COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics	7	0
12649	4	12538 2001 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 86(5):2263-2269 Masi L; Becherini L; Gennari L; Amedei A; Colli E; Falchetti A; Farci M; Silvestri S; Gonnelli S; Brandi ML Polymorphism of the aromatase gene in postmenopausal Italian women: Distribution and correlation with bone mass and fracture risk	9	0
12650	5	12539 2001 JOURNAL OF CLINICAL PHARMACOLOGY 41(7):723-731 McCune JS; Lindley C; Decker JL; Williamson KM; Meadowcroft AM; Graff D; Sawyer WT; Blough DK; Pieper JA Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan	2	0
12651	49	12540 2001 JOURNAL OF CLINICAL PHARMACOLOGY 41(11):1149-1179 Venkatakrishnan K; von Moltke LL; Greenblatt DJ Human drug metabolism and the cytochromes P450: Application and relevance of in vitro models	24	0
12652	3	12541 2001 JOURNAL OF ETHNOPHARMACOLOGY 77(1):31-35 Czinner E; Hagymasi K; Blazovics A; Kery A; Szoke E; Lemberkovics E The in vitro effect of Helichrysi flos on microsomal lipid peroxidation	3	0
12653	12	12543 2001 JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 49(2):229-236 Muskhelishvili L; Thompson PA; Kusewitt DF; Wang C; Fadlubar FF In situ hybridization and immunohistochemical analysis of cytochrome P4501B1 expression in human normal tissues	18	0
12654	2	12545 2001 JOURNAL OF IMMUNOLOGY 166(4):2479-2486 Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD A novel role of complement: Mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration	14	0
12655	13	12546 2001 JOURNAL OF INORGANIC BIOCHEMISTRY 87(4):185-190 Shumyantseva VV; Bulko TV; Usanov SA; Schmid RD; Nicolini C; Archakova AI Construction and characterization of bioelectrocatalytic sensors based on cytochromes P450	1	0
12656	8	12548 2001 JOURNAL OF INORGANIC BIOCHEMISTRY 87(4):237-244 Gilep AA; Guryev OL; Usanov SA; Estabrook RW Apo-cytochrome b(5) as an indicator of changes in heme accessability: Preliminary studies with cytochrome P450 3A4	0	0
12657	2	12550 2001 JOURNAL OF MOLECULAR ENDOCRINOLOGY 27(3):259-274 Soulez M; Parker MG Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling	3	0
12658	5	12551 2001 JOURNAL OF MOLECULAR MODELING 7(5):140-142 Archakov A; Lisitsa A; Gusev S; Koymans L; Janssen P Inventory of the cytochrome P450 superfamily	1	0
12659	1	12553 2001 JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 14(1):27-35 Mathur R; Menon PSN; Kabra M; Goyal RK; Verma IC Molecular characterization of mutations in Indian children with congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency	1	0
12660	29	12556 2001 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 299(1):39-47 Tsao CC; Coulter SJ; Chien A; Luo G; Clayton NP; Maronpot R; Goldstein JA; Zeldin DC Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products	3	0
12661	3	12557 2001 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 299(2):718-728 Santini RP; Myrand S; Elferink C; Reiners JJ Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase	2	0
12662	3	12558 2001 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 299(3):858-865 Zhong Z; Li XL; Yamashina SH; Von Frankenberg M; Enomoto N; Ikejima K; Kolinsky M; Raleigh JA; Thurman RG Cyclosporin A causes a hypermetabolic state and hypoxia in the liver: Prevention by dietary glycine	3	0
12663	8	12559 2001 JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 63(1-3):61-69 Afaq F; Mukhtar H Effects of solar radiation on cutaneous detoxification pathways	4	0
12664	4	12560 2001 JOURNAL OF PROTEIN CHEMISTRY 20(6):487-493 Wang YH; Ren Y; Wang WH; Xie Y; Huang ZX The regulation of surface charged residues on the properties of cytochrome b(5)	0	0
12665	1	12561 2001 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 78(4):359-366 Le Curieux-Belfond O; Moslemi S; Mathieu M; Seralini GE Androgen metabolism in oyster Crassostrea gigas: evidence for 17 beta-HSD activities and characterization of an aromatase- like activity inhibited by pharmacological compounds and a marine pollutant	2	0
12666	3	12562 2001 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 79(1-5):255-260 Honda SI; Matsumoto T; Harada N Characterization and purification of a protein binding to the cis-acting element for brain-specific exon 1 of the mouse aromatase gene	0	0
12667	4	12564 2001 JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 24(4):299-302 Hunter RP; Short CR; Dees AA Interaction of cimetidine with equine hemoglobin	0	0
12668	14	12565 2001 LIFE SCIENCES 68(18):2141-2150 Guigal N; Seree E; Nguyen QB; Charvet B; Desobry A; Barra Y Serum induces a transcriptional activation of CYP1A1 gene in HepG2 independently of the AhR pathway	3	0
12669	10	12566 2001 MARINE BIOTECHNOLOGY 3(3):218-223 Mitsuo R; Sato M; Itakura T Cloning, sequencing, and phylogenetic analysis of complementary DNA of novel cytochrome P-450CYP1A in Japanese eel (Anguilla japonica)	0	0
12670	15	12567 2001 MEDICINAL RESEARCH REVIEWS 21(5):397-411 Kumar GN; Surapaneni S Role of drug metabolism in drug discovery and development	6	0
12671	13	12568 2001 METABOLISM-CLINICAL AND EXPERIMENTAL 50(2):231-236 Kurokohchi K; Yoneyama H; Nishioka M; Ichikawa Y Inhibitory effect of rifampicin on the depressive action of interleukin-1 on cytochrome P-450-linked monooxygenase system	0	0
12672	9	12569 2001 METHODS IN CELL BIOLOGY, VOL 65 65():1-35 Pallotti F; Lenaz G Isolation and subfractionation of mitochondria from animal cells and tissue culture lines	9	0
12673	4	12570 2001 MOLECULAR AND CELLULAR BIOCHEMISTRY 220(1-2):49-56 Sanllorenti PM; Rosenfeld J; Ronchi VP; Ferrara P; Conde RD Two dimensional non-equilibrium pH gel electrophoresis mapping of cytosolic protein changes caused by dietary protein depletion in mouse liver	1	0
12674	8	12571 2001 MOLECULAR AND CELLULAR BIOCHEMISTRY 220(1-2):117-125 MacDonald MJ; Marshall LK Survey of normal appearing mouse strain which lacks malic enzyme and NAD(+)-linked glycerol phosphate dehydrogenase: Normal pancreatic beta cell function, but abnormal metabolite pattern in skeletal muscle	4	0
12675	1	12572 2001 MOLECULAR AND CELLULAR BIOLOGY 21(18):6243-6253 Torkko JM; Koivuranta KT; Miinalainen IJ; Yagi AI; Schmitz W; Kastaniotis AJ; Airenne TT; Gurvitz A; Hiltunen KJ Candida tropicalis Etr1p and Saccharomyces cerevisiae Ybr026p (Mrf1 ' p), 2-enoyl thioester reductases essential for mitochondrial respiratory competence	4	0
12676	7	12575 2001 MOLECULAR BIOLOGY AND EVOLUTION 18(10):1841-1848 Warner SC; Finta C; Zaphiropoulos PG Intergenic transcripts containing a novel human cytochrome P4502C exon 1 spliced to sequences from the CYP2C9 gene	2	0
12677	6	12579 2001 MOLECULAR PHARMACOLOGY 59(5):1138-1146 Sidhu JS; Liu F; Boyle SM; Omiecinski CJ PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes	3	0
12678	10	12580 2001 MOLECULAR PHARMACOLOGY 59(6):1402-1409 Hirsch-Ernst KI; Schlaefer K; Bauer D; Heder AF; Kahl GF Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures	1	0
12679	8	12585 2001 MOLECULAR PLANT-MICROBE INTERACTIONS 14(7):918-924 Luyten E; Swinnen E; Vlassak K; Verreth C; Dombrecht B; Vanderleyden J Analysis of a symbiosis-specific cytochrome P450 homolog in Rhizobium sp, BR816	1	0
12680	4	12588 2001 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 482(1-2):27-40 Glatt H; Boeing H; Engelke CEH; Kuhlow LMA; Pabel U; Pomplun D; Teubner W; Meinl W Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects	11	0
12681	9	12593 2001 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 498(1-2):57-66 Rahden-Staron I; Czeczot H; Szumilo M Induction of rat liver cytochrome P450 isoenzymes CYP 1A and CYP2B by different fungicides, nitrofurans, and quercetin	5	0
12682	36	12595 2001 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 488(3):195-209 Guengerich FP Forging the links between metabolism and carcinogenesis	5	0
12683	4	12596 2001 MYCOLOGICAL RESEARCH 105():1223-1230 Eastwood DC; Kingsnorth CS; Jones HE; Burton KS Genes with increased transcript levels following harvest of the sporophore of Agaricus bisporus have multiple physiological roles	2	0
12684	11	12597 2001 NATURAL PRODUCT REPORTS 18(5):465-493 Bugg TDH The development of mechanistic enzymology in the 20th century	0	0
12685	1	12599 2001 NEUROCHEMISTRY INTERNATIONAL 38(7):567-572 Maruyama Y; Teraoka H; Iwata H; Kazusaka A; Fujita S Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells	0	0
12686	1	12600 2001 NEUROENDOCRINOLOGY LETTERS 22(6):435-440 Gajewska A; Kochman K GnRH pulsality and the differential activation of the rat luteinizing hormone subunit genes in the anterior pituitary gland	1	0
12687	2	12601 2001 NEUROSCIENCE LETTERS 310(2-3):141-144 Nakashima T; Yoshida Y; Miyata S; Kiyohara T Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1 beta in the rat	2	0
12688	27	12602 2001 NEUROSTEROIDS AND BRAIN FUNCTION 46():33-78 Mellon SH; Vaudry H Biosynthesis of neurosteroids and regulation of their synthesis	7	0
12689	4	12603 2001 NEUROSTEROIDS AND BRAIN FUNCTION 46():79-95 Morfin R; Starka L Neurosteroid 7-hydroxylation products in the brain	3	0
12690	5	12604 2001 NEW ENGLAND JOURNAL OF MEDICINE 344(13):984-996 Piscitelli SC; Gallicano KD Drug therapy: Interactions among drugs for HIV and opportunistic infections	46	0
12691	6	12605 2001 NIEREN-UND HOCHDRUCKKRANKHEITEN 30(5):219-223 Lauterbach B; Lohn M; Gollasch M; Luft FC; Haller H; Honeck H; Kargel E; Sicard EB; Schunck WH Action of K-Ca channels by 11,12-epoxyeicosantrienoic acid in freshly isolated vascular muscle cells from cerebral arteries of the rat	0	0
12692	4	12606 2001 NUTRITION AND CANCER PREVENTION 492():83-106 Pinto JT; Lapsia S; Shah A; Santiago H; Kim G Antiproliferative effects of garlic-derived and other allium related compounds	0	0
12693	9	12607 2001 NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 41(1-2):188-195 Tsai CF; Lii CK; Yang JJ; Liu KL; Lin WL; Chen HW Prostaglandin E-2 is involved in the increase of cytochrome P- 450 2B1 expression by alpha-tocopheryl succinate in primary rat hepatocytes in the presence of phenobarbital	1	0
12694	3	12609 2001 PEDIATRIC TRANSPLANTATION 5(2):75-79 Mittal N; Thompson JF; Kato T; Tzakis AG Tacrolimus and diarrhea: Pathogenesis of altered metabolism	6	0
12695	37	12610 2001 PEST MANAGEMENT SCIENCE 57(10):958-967 Scott JG; Wen ZM Cytochromes P450 of insects: the tip of the iceberg	4	0
12696	4	12611 2001 PEST MANAGEMENT SCIENCE 57(10):975-980 Kayser H; Eilinger P Metabolism of diafenthiuron by microsomal oxidation: procide activation and inactivation as mechanisms contributing to selectivity	0	0
12697	8	12612 2001 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 70(2):63-73 Suwanchaichinda C; Brattsten LB Effects of exposure to pesticides on carbaryl toxicity and cytochrome P450 activities in Aedes albopictus larvae (Diptera : Culicidae)	2	0
12698	13	12620 2001 PHARMACOGENETICS 11(9):793-801 Jansson I; Stoilov I; Sarfarazi M; Schenkman JB Effect of two mutations of human CYP1B1, G61E and R469W, on stability and endogenous steroid substrate metabolism	4	0
12699	2	12622 2001 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 359(1783):1055-1072 Bassingthwaighte JB The modelling of a primitive 'sustainable' conservative cell	2	0
12700	15	12623 2001 PHYSIOLOGIA PLANTARUM 111(2):172-181 Mujer CV; Smigocki AC Cytokinin- and wound-inducible cytochrome P450 from Nicotiana plumbaginifolia	1	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12701	5	12624 2001 PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY 59(2):83-93 Vanetten H; Temporini E; Wasmann C Phytoalexin (and phytoanticipin) tolerance as a virulence trait: why is it not required by all pathogens?	2	0
12702	10	12625 2001 PHYTOPATHOLOGY 91(1):102-110 Schnabel G; Jones AL The 14 alpha-demethylase (CYP51A1) gene is overexpressed in Venturia inaequalis strains resistant to myclobutanil	4	0
12703	5	12626 2001 PLANT CELL REPORTS 20(7):655-662 Yamamura Y; Ogihara Y; Mizukami H Cinnamic acid 4-hydroxylase from Lithospermum erythrorhizon: cDNA cloning and gene expression	2	0
12704	5	12628 2001 PLANTA 213(3):411-417 Nezbedova L; Hesse M; Drandarov K; Bigler L; Werner C Phenol oxidative coupling in the biogenesis of the macrocyclic spermine alkaloids aphelandrine and orantine in Aphelandra sp.	1	0
12705	2	12629 2001 PRESSE MEDICALE 30(10):508-510 Eschwege P; de Ledinghen V; Camilli T; Kulkarni S; Dalbagni G; Droupy S; Jardin A; Benoit G; Weksler BB Cyclooxygenase-2: a new target for epithelial cancer treatments - Arachidonic acid and prostaglandins, inflammation and oncology	1	0
12706	2	12630 2001 PRESSE MEDICALE 30(10):511-514 Eschwege P; de Ledinghen V; Camilli T; Kulkarni S; Dalbagni G; Droupy S; Jardin A; Benoit G; Weksler BB Cyclooxygenase-2: a new target for epithelial cancer treatments - Cyclooxygenases	1	0
12707	30	12631 2001 PROBING OF PROTEINS BY METAL IONS AND THEIR LOW-MOLECULAR- WEIGHT COMPLEXES 38():461-655 Feiters MC Mimicking biological electron transfer and oxygen activation involving iron and copper proteins: A bio(in)organic supramolecular approach	1	0
12708	5	12634 2001 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 28(1):61-66 Zhu CL; Li JM; Gao XH; Tian HS; Li XL; Shen B; Wu GL Studies on cytochrome P450 genes in the mosquito, Culex pipiens pallens, in China	0	0
12709	1	12635 2001 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 28(3):372-376 Liu K; Sun J; Liu Y; Zhang QY; Kuang TY ESR studies on the superoxide radicals generated in photosystem II of higher plant	1	0
12710	8	12638 2001 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 109(1-2):53-63 Taguchi M; Imaoka S; Yoshii K; Kobayashi K; Hosokawa M; Shimada N; Funae Y; Chiba K Kinetics of testosterone 6 beta-hydroxylation in the reconstituted system with similar ratios of purified CYP3A4, NADPH-cytochrome P450 oxidoreductase and cytochrome B-5 to human liver microsomes	0	0
12711	15	12640 2001 REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE 41(6):579-586 Haag M; Frossard N; Pons F Cytochromes P450 and glutathione S-transferases: any association with inflammation and asthma?	0	0
12712	2	12641 2001 SAR AND QSAR IN ENVIRONMENTAL RESEARCH 12(4):359-366 Lisitsa AV; Gusev SA; Karuzina II; Archakov AI; Koymans L Cytochrome P450 database	0	0
12713	2	12642 2001 TALANTA 54(5):983-987 Baltes MRH; Dubois JG; Hanocq M Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice	0	0
12714	9	12644 2001 TETRAHEDRON LETTERS 42(41):7211-7212 Falck JR; Kumar PS; Reddy YK; Zou G; Capdevila JH Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling	5	0
12715	11	12645 2001 THEORETICAL AND APPLIED GENETICS 103(6-7):1014-1021 Fischer TC; Klattig JT; Gierl A A general cloning strategy for divergent plant cytochrome P450 genes and its application in Lolium rigidum and Ocimum basilicum	1	0
12716	1	12646 2001 THERAPEUTIC DRUG MONITORING 23(1):21-26 Lee M; Min DI Determination of sildenafil citrate in plasma by high- performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate	5	0
12717	3	12647 2001 TOXICOLOGIC PATHOLOGY 29():155-160 Carmichael PL; Mills JJ; Campbell M; Basu M; Caldwell J Mechanisms of hormonal carcinogenesis in the p53(+/-)- hemizygous knockout mouse: Studies with diethylstilbestrol	2	0
12718	18	12648 2001 TOXICOLOGICAL SCIENCES 60(1):77-91 Bello SM; Franks DG; Stegeman JJ; Hahn ME Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: In vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes	14	0
12719	6	12649 2001 TOXICOLOGY 166(3):139-160 Jokanovic M Biotransformation of organophosphorus compounds	1	0
12720	14	12650 2001 TOXICOLOGY AND APPLIED PHARMACOLOGY 172(3):163-171 Serron SC; Zhang SX; Bergeron RM; Backes WL Effect of hypophysectomy and growth hormone replacement on the modulation of P450 expression after treatment with the aromatic hydrocarbon ethylbenzene	3	0
12721	3	12651 2001 TOXICOLOGY AND APPLIED PHARMACOLOGY 172(3):194-202 Reid MJ; Bornheim LM The effects of phencyclidine pretreatment on cocaine-mediated hepatotoxicity in mice	1	0
12722	11	12652 2001 VOPROSY MEDITSINSKOI KHIMII 47(3):315-328 Prozrovsky TV; Schunck WH; Archakov AI Association of cytochrome P4502B4 with molecular chaperones after hetrologous expression in E.coli.	0	0
12723	14	12656 2001 XENOBIOTICA 31(5):265-275 Emoto C; Yamazaki H; Iketaki H; Yamasaki S; Satoh T; Shimizu R; Suzuki S; Shimada N; Nakajima M; Yokoi T Cooperativity of alpha-naphthoflavone in cytochrome P450 3A- dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human	4	0
12724	10	12658 2001 XENOBIOTICA 31(10):713-723 Miyazawa M; Shindo M; Shimada T Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes	1	0
12725	15	12659 2001 XENOBIOTICA 31(12):861-878 Renwick AB; Lavignette G; Worboys PD; Williams B; Surry D; Lewis DFV; Price RJ; Lake BG; Evans DC Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7- benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes	0	0
12726	3	12660 2001 ZEITSCHRIFT FUR GASTROENTEROLOGIE 39(3):225-+ Stickel F; Seitz HK; Hahn EG; Schuppan D Hepatotoxicity of herbal remedies	2	0
12727	8	12661 2002 ACTA PHARMACOLOGICA SINICA 23(5):471-476 Xia XY; Peng RX; Yu JP; Wang H; Wang J In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes	0	0
12728	27	12662 2002 ADVANCED DRUG DELIVERY REVIEWS 54(3):367-383 de Groot MJ; Ekins S Pharmacophore modeling of cytochromes P450	3	0
12729	12	12663 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1245-1256 Xu C; Goodz S; Sellers EA; Tyndale RF CYP2A6 genetic variation and potential consequences	1	0
12730	16	12664 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1257-1270 Xie HG; Prasad HC; Kim RB; Stein CM CYP2C9 allelic variants: ethnic distribution and functional significance	1	0
12731	42	12665 2002 ADVANCED DRUG DELIVERY REVIEWS 54(10):1271-1294 Lamba JK; Lin YS; Schuetz EG; Thummel KE Genetic contribution to variable human CYP3A-mediated metabolism	1	0
12732	23	12666 2002 ADVANCED SYNTHESIS & CATALYSIS 344(9):932-937 Cirino PC; Arnold FH Regioselectivity and activity of cytochrome P450 BM-3 and mutant F87A in reactions driven by hydrogen peroxide	0	0
12733	4	12667 2002 ALCOHOL AND WINE IN HEALTH AND DISEASE 957():210-229 Bhat KPL; Pezzuto JM Cancer chemopreventive activity of resveratrol	13	0
12734	12	12668 2002 AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY 59(21):2061-2069 Ma MK; Woo MH; McLeod HL Genetic basis of drug metabolism	1	0
12735	3	12669 2002 AMERICAN JOURNAL OF MEDICINE 113(9):746-750 Rogers JF; Nafziger AN; Bertino JS Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs	0	0
12736	7	12670 2002 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283(1):C85-C92 Lax A; Soler F; Fernandez-Belda F Inhibition of sarcoplasmic reticulum Ca2+-ATPase by miconazole	0	0
12737	8	12671 2002 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 282(2):G338-G348 Takahashi M; Tsuboyama-Kasaoka N; Nakatani T; Ishii M; Tsutsumi S; Aburatani H; Ezaki O Fish oil feeding alters liver gene expressions to defend against PPAR alpha activation and ROS production	4	0
12738	11	12672 2002 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 283(5):H1936-H1942 Snyder GD; Krishna UM; Falck JR; Spector AA Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle	1	0
12739	3	12673 2002 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 283(3):R598-R603 Veauvy CM; Wang YX; Walsh PJ; Perez-Pinzon MA Comparison of the effects of ammonia on brain mitochondrial function in rats and gulf toadfish	0	0
12740	1	12674 2002 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 282(6):F981-F990 Michea L; Combs C; Andrews P; Dmitrieva N; Burg MB Mitochondrial dysfunction is an early event in high-NaCl- induced apoptosis of mIMCD3 cells	3	0
12741	5	12675 2002 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 166(1):118-119 Wasserman K Mitochondrial disorders and exertional intolerance: Controversy continues	0	0
12742	6	12676 2002 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 166(1):119-120 Flaherty KR; Blaivas MM; Wald J; Rubenfire M; Martinez FJ; Weisman IM; Zeballos RJ Mitochondrial disorders and exertional intolerance: Controversy continues	0	0
12743	7	12677 2002 ANAESTHESIST 51(1):2-15 Papp-Jambor C; Jaschinski U; Forst H Cytochrome P450 enzymes and their role in drug interactions	1	0
12744	12	12678 2002 ANALYTICA CHIMICA ACTA 457(2):165-171 Li XF; Ma MS; Cheng A; Zheng J; Tam YK Determination of testosterone and its metabolites using liquid chromatography with elevated column temperature and flow-rate gradient	0	0
12745	14	12679 2002 ANALYTICA CHIMICA ACTA 465(1-2):227-236 Yamane M High-performance liquid chromatography-thermo spray ionization- mass spectrometry of the oxidation products of polyunsaturated- fatty acids	0	0
12746	9	12680 2002 ANALYTICAL BIOCHEMISTRY 300(2):121-131 Endrizzi K; Fischer J; Klein K; Schwab M; Nussler A; Neuhaus P; Eichelbaum M; Zanger UM Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction	0	0
12747	12	12682 2002 ANNUAL REVIEW OF NUTRITION 22():139-166 Omdahl JL; Morris HA; May BK Hydroxylase enzymes of the vitamin D pathway: Expression, function, and regulation	1	0
12748	2	12684 2002 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 42():113-133 Altman RB; Klein TE Challenges for biomedical informatics and pharmacogenomics	6	0
12749	5	12687 2002 ANTICANCER RESEARCH 22(3):1699-1703 Huynh HT; Teel RW Effects of plant-derived phenols on rat liver cytochrome p450 2B1 activity	1	0
12750	8	12688 2002 ANTIOXIDANTS & REDOX SIGNALING 4(5):701-709 Jones BE; Liu HL; Lo CR; Koop DR; Czaja MJ Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress	0	0
12751	7	12690 2002 APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 58(1):97-105 Ichinose H; Wariishi H; Tanaka H Identification and characterization of novel cytochrome P450 genes from the white-rot basidiomycete, Coriolus versicolor	7	0
12752	10	12691 2002 AQUATIC TOXICOLOGY 60(3-4):269-283 Ortiz-Delgado JB; Sarasquete C; Behrens A; de Canales MLG; Segner H Expression, cellular distribution and induction of cytochrome P4501A (CYP1A) in gilthead seabream, Sparus aurata, brain	0	0
12753	0	12692 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 397(2):137-138 Estabrook RW Introduction - Earl R. Stadtman: A conqueror of enzymes and maker of kings	0	0
12754	7	12693 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 400(1):63-75 Davis CA; Dhawan IK; Johnson MK; Barber MJ Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: Identification of histidines 62 and 85 as the heme axial ligands	0	0
12755	11	12694 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 404(2):326-334 Iba MM; Nguyen T; Fung J CYP1A1 induction by pyridine and its metabolites in HepG2 cells	0	0
12756	16	12695 2002 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 407(1):95-102 Headlam MJ; Tuckey RC The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration	0	0
12757	6	12696 2002 ARCHIVES OF NEUROLOGY 59(9):1395-1402 Haller RG; Vissing J Spontaneous "second wind" and glucose-induced second "second wind" in McArdle disease - Oxidative mechanisms	1	0
12758	5	12697 2002 ARCHIVES OF PHARMACAL RESEARCH 25(3):375-380 Chung I; Jung K No role of protected region B of human cytochrome P4501A2 gene (CYP1A2) as an AP-1 response element	0	0
12759	7	12698 2002 ARCHIVES OF TOXICOLOGY 76(5-6):326-334 Roos PH; Tschirbs S; Welge P; Hack A; Theegarten D; Mogilevski G; Wilhelm M Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH)	0	0
12760	10	12699 2002 ARCHIVES OF TOXICOLOGY 76(11):621-627 Haag M; Leusink-Muis T; Le Bouquin R; Nijkamp FP; Lugnier A; Frossard N; Folkerts G; Pons F Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma	0	0
12761	8	12700 2002 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 52(10):745-753 Fujino H; Yamada I; Shimada S; Nagao T; Yoneda M Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3- hydroxy-3-methylglutaryl coenzyme a reductase - Effects on drug-metabolizing systems in rats and humans	1	0
12762	9	12701 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 293(3):969-973 Nakamura K; Ariyoshi N; Yokoi T; Ohgiya S; Chida M; Nagashima K; Inoue K; Kodama T; Shimada N; Kamataki T CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability	0	0
12763	12	12702 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 294(5):1071-1078 Sumita T; Iida T; Yamagami S; Horiuchi H; Takagi M; Ohta A YlALK1 encoding the cytochrome P450ALK1 in Yarrowia lipolytica is transcriptionally induced by n-alkane through two distinct cis-elements on its promoter	0	0
12764	10	12703 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 297(1):65-70 Zhu ZY; Hotchkiss SA; Boobis AR; Edwards RJ Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes	0	0
12765	13	12704 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 298(2):277-281 Barque JP; Abahamid A; Flinois JP; Beaune P; Bonaly J Constitutive overexpression of immunoidentical forms of PCP- induced Euglena gracilis CYP-450	0	0
12766	13	12706 2002 BIOCHEMICAL JOURNAL 363():297-303 Lundell K Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]	0	0
12767	9	12707 2002 BIOCHEMICAL PHARMACOLOGY 63(4):615-624 De Matteis F; Dawson SJ; Pons N; Pipino S Bilirubin and uroporphyrinogen oxidation by induced cytochrome P4501A and cytochrome P4502B - Role of polyhalogenated biphenyls of different configuration	0	0
12768	28	12710 2002 BIOCHEMICAL PHARMACOLOGY 64(10):1447-1460 Ma JX; Bradbury JA; King L; Maronpot R; Davis LS; Breyer MD; Zeldin DC Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform	0	0
12769	15	12712 2002 BIOCHEMISTRY 41(26):8310-8320 Usanov SA; Graham SE; Lepesheva GI; Azeva TN; Strushkevich NV; Gilep AA; Estabrook RW; Peterson JA Probing the interaction of bovine cytochrome P450scc (CYP11A1) with adrenodoxin: Evaluating site-directed mutations by molecular modeling	0	0
12770	19	12713 2002 BIOCHEMISTRY 41(30):9438-9447 Kim JS; Ahn T; Yim SK; Yun CH Differential effect of copper (II) on the cytochrome P450 enzymes and NADPH-cytochrome P450 reductase: Inhibition of cytochrome P450-catalyzed reactions by copper (II) ion	0	0
12771	9	12715 2002 BIOCHEMISTRY 41(46):13514-13525 Kariakin A; Davydov D; Peterson JA; Jung C A new approach to the study of protein-protein interaction by FTIR: Complex formation between cytochrome P450BM-3 heme domain and FMN reductase domain	0	0
12772	7	12716 2002 BIOCHEMISTRY 41(49):14499-14508 Prasad S; Mitra S Role of protein and substrate dynamics in catalysis by Pseudomonas putida cytochrome P450(cam)	0	0
12773	12	12717 2002 BIOCHEMISTRY-MOSCOW 67(4):456-467 Shkumatov VM; Usova EV; Poljakov YS; Frolova NS; Radyuk VG; Mauersberger S; Chernogolov AA; Honeck H; Schunck WH Biotransformation of steroids by a recombinant yeast strain expressing bovine cytochrome P-45017 alpha	1	0
12774	5	12718 2002 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1595(1-2):80-93 Lange R; Balny C UV-visible derivative spectroscopy under high pressure	3	0
12775	12	12719 2002 BIOLOGICAL CHEMISTRY 383(6):923-932 Rueff J; Gaspar J; Kranendonk M DNA polymorphisms as modulators of genotoxicity and cancer	0	0
12776	34	12720 2002 BIOLOGICAL CHEMISTRY 383(10):1537-1551 Bureik M; Lisurek M; Bernhardt R The human steroid hydroxylases CYP11B1 and CYP11B2	0	0
12777	56	12721 2002 BIOLOGICAL CHEMISTRY 383(10):1553-1564 Guengerich FP Rate-limiting steps in cytochrome P450 catalysis	0	0
12778	10	12722 2002 BIOLOGICAL TRACE ELEMENT RESEARCH 89(2):177-190 Iscan M; Ada AO; Coban T; Kapucuoglu N; Aydin A; Isimer A Combined effects of cadmium and nickel on testicular xenobiotic metabolizing enzymes in rats	0	0
12779	1	12723 2002 BIOLOGICHESKIE MEMBRANY 19(6):451-471 Azizova OA Role of free radical processes in the development of atherosclerosis	0	0
12780	5	12724 2002 BIOMARKERS 7(3):209-229 Nia AB; Kleinjans JCS; Van Schooten FJ Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbons	1	0
12781	3	12725 2002 BIOMEDICAL CHROMATOGRAPHY 16(3):199-202 Maboudou P; Matheiu D; Bachelet H; Wiart JF; Lhermitte M Detection of oxidative stress. Interest of GC-MS for malondialdehyde and formaldehyde monitoring	1	0
12782	4	12727 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(8):2479-2483 Yu BW; Ruppert M; Stockigt J Deoxysarpagine hydroxylase - A novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia	0	0
12783	4	12728 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(9):2981-2985 Tsukamoto S; Tomise K; Miyakawa K; Cha BC; Abe T; Hamada T; Hirota H; Ohta T CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper	1	0
12784	5	12729 2002 BIOPHYSICAL JOURNAL 82(1):99-108 Reijenga KA; Westerhoff HV; Kholodenko BN; Snoep JL Control analysis for autonomously oscillating biochemical networks	6	0
12785	4	12730 2002 BIOPHYSICAL JOURNAL 82(5):2811-2825 Huang SH; Heikal AA; Webb WW Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein	4	0
12786	13	12734 2002 BRITISH JOURNAL OF CANCER 87(6):681-686 Martinez C; Garcia-Martin E; Pizarro RM; Garcia-Gamito FJ; Agundez JAG Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy	1	0
12787	4	12735 2002 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 53(4):393-397 Cho JY; Yu KS; Jang IJ; Yang BH; Shin SG; Yim DS Omeprazole hydroxylation is inhibited by a single dose of moclobemide in homozygotic EM genotype for CYP2C19	1	0
12788	9	12736 2002 BRITISH JOURNAL OF PHARMACOLOGY 135(4):977-986 Krauskopf A; Buetler TM; Nguyen NSD; Mace K; Ruegg UT Cyclosporin A-induced free radical generation is not mediated by cytochrome P-450	1	0
12789	3	12737 2002 BUNSEKI KAGAKU 51(1):13-19 Maehana K; Tani H; Kamataki T; Kamidate T Affinity partitioning of histidine-tagged cytochrome b(5) and an oligopeptide in an aqueous micellar two-phase system containing a metal-chelating polymer	0	0
12790	5	12738 2002 CANADIAN JOURNAL OF MICROBIOLOGY 48(1):49-59 Morgan CA; Wyndham RC Characterization of tdt genes for the degradation of tricyclic diterpenes by Pseudomonas diterpeniphila A19-6a	1	0
12791	3	12739 2002 CARCINOGENESIS 23(7):1095-1102 Grover PL; Martin FL The initiation of breast and prostate cancer	0	0
12792	2	12740 2002 CELL BIOCHEMISTRY AND FUNCTION 20(1):47-59 Hemmings SJ; Pulga VB; Tran ST; Uwiera RRE Differential inhibitory effects of carbon tetrachloride on the hepatic plasma membrane, mitochondrial and endoplasmic reticular calcium transport systems: implications to hepatotoxicity	1	0
12793	2	12742 2002 CHEMICAL RESEARCH IN TOXICOLOGY 15(3):332-342 Platt KL; Degenhardt C; Grupe S; Frank H; Seidel A Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites	0	0
12794	5	12743 2002 CHEMICAL RESEARCH IN TOXICOLOGY 15(7):927-934 Miller RT Dinitrobenzene-mediated production of peroxynitrite by neuronal nitric oxide synthase	1	0
12795	17	12744 2002 CHEMICAL RESEARCH IN TOXICOLOGY 15(12):1561-1571 Blobaum AL; Kent UM; Alworth WL; Hollenberg PF Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: Characterization of reactive intermediate adducts to the heme and apoprotein	0	0
12796	18	12745 2002 CHEMICAL REVIEWS 102(4):1019-1065 Lee J; Chen L; West AH; Richter-Addo GB Interactions of organic nitroso compounds with metals	2	0
12797	2	12746 2002 CHEMICAL SENSES 27(6):529-537 Giorgi D; Rouquier S Identification of V1R-like putative pheromone receptor sequences in non-human primates. Characterization of V1R pseudogenes in marmoset, a primate species that possesses an intact vomeronasal organ	1	0
12798	11	12747 2002 CHEMISTRY & BIOLOGY 9(5):555-565 Valderrama B; Ayala M; Vazquez-Duhalt R Suicide inactivation of peroxidases and the challenge of engineering more robust enzymes	0	0
12799	4	12748 2002 CHINESE JOURNAL OF CHEMISTRY 20(11):1225-1234 Wu J; Wang YH; Gan JH; Wang WH; Sun BY; Huang ZX; Xia ZX Structures of cytochrome b(5) mutated at the charged surface- residues and their interactions with cytochrome c	0	0
12800	13	12749 2002 CLINICA CHIMICA ACTA 325(1-2):117-125 Abraham P; Wilfred G; Ramakrishna B Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12801	7	12750 2002 CLINICAL NEUROPHARMACOLOGY 25(5):280-289 Mula M; Monaco F Antiepileptic-antipsychotic drug interactions: A critical review of the evidence	0	0
12802	51	12751 2002 CLINICAL PHARMACOKINETICS 41(12):959-998 Alcorn J; McNamara PJ Ontogeny of hepatic and renal systemic clearance pathways in infants - Part I	3	0
12803	12	12752 2002 CLINICAL PHARMACOLOGY & THERAPEUTICS 71(3):196-204 Garcia-Martin E; Martinez C; Pizarro RM; Garcia-Gamito FJ; Gullsten H; Raunio H; Agundez JAG CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity	2	0
12804	7	12753 2002 CNS DRUGS 16(4):229-247 Naguib M; Koorn R Interactions between psychotropics, anaesthetics and electroconvulsive therapy - Implications for drug choice and patient management	1	0
12805	15	12754 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 132(2):181-191 Tilley RE; Kemp GD; Teramitsu I; Hall AJ Isolation of two cytochrome P450 cDNAs, CYP1A1 and CYP1A2, from harp seal (Phoca groenlandica) and grey seal (Halichoerus grypus)	0	0
12806	18	12755 2002 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 133(4):613-624 Arukwe A Complementary DNA cloning, sequence analysis and differential organ expression of beta-naphthoflavone-inducible cytochrome P4501A in Atlantic salmon (Salmo salar)	0	0
12807	52	12756 2002 CRITICAL REVIEWS IN TOXICOLOGY 32(5):391-411 Hukkanen J; Pelkonen A; Hakkola J; Raunio H Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung	2	0
12808	19	12757 2002 CURRENT DRUG METABOLISM 3(1):39-59 de Kanter R; Monshouwer M; Meijer DKF; Groothuis GMM Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues	3	0
12809	2	12758 2002 CURRENT DRUG METABOLISM 3(1):97-113 Perek N; Denoyer D The multidrug resistance mechanisms and their interactions with the radiopharmaceutical probes used for an in vivo detection	0	0
12810	9	12759 2002 CURRENT DRUG METABOLISM 3(3):233-255 Conaway CC; Yang YM; Chung FL Isothiocyanates as cancer chemopreventive agents: Their biological activities and metabolism in rodents and humans	2	0
12811	7	12760 2002 CURRENT DRUG METABOLISM 3(5):481-490 Rushmore TH; Kong ANT Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes	3	0
12812	121	12761 2002 CURRENT DRUG METABOLISM 3(6):561-597 Danielson PB The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans	4	0
12813	29	12764 2002 CURRENT PHARMACEUTICAL DESIGN 8(15):1335-1347 Patterson LH; Murray GI Tumour cytochrome P450 and drug activation	3	0
12814	18	12765 2002 CYTOCHROME P450, PT C 357():261-276 Shou MG Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450	0	0
12815	14	12766 2002 CYTOCHROME P450, PT C 357():301-310 Kamataki B; Fujita K Mutagenesis testing based on bacterial expression of human P450s	0	0
12816	12	12767 2002 CYTOCHROME P450, PT C 357():370-381 Kutchan TM; Schroder J Selected cell cultures and induction methods for cloning and assaying cytochromes P450 in alkaloid pathways	0	0
12817	1	12768 2002 DIGESTION 66(2):79-88 Kiba T The role of the autonomic nervous system in liver regeneration and apoptosis - Recent developments	1	0
12818	1	12769 2002 DNA AND CELL BIOLOGY 21(4):281-295 Stojiljkovic I; Perkins-Balding D Processing of heme and heme-containing proteins by bacteria	2	0
12819	10	12771 2002 DRUG METABOLISM AND DISPOSITION 30(2):177-182 Shaw AA; Hall SD; Franklin MR; Galinsky RE The influence of L-glutamine on the depression of hepatic cytochrome P450 activity in male rats caused by total parenteral nutrition	1	0
12820	6	12772 2002 DRUG METABOLISM AND DISPOSITION 30(3):235-239 Suzuki H; Kneller MB; Haining RL; Trager WF; Rettie AE (+)-N-3-benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19	2	0
12821	5	12773 2002 DRUG METABOLISM AND DISPOSITION 30(3):270-275 Fisher MB; Jackson D; Kaerner A; Wrighton SA; Borel AG Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarinin human liver microsomes treated with alamethicin	0	0
12822	8	12776 2002 DRUG METABOLISM AND DISPOSITION 30(4):391-396 Hanioka N; Ozawa S; Jinno H; Tanaka-Kagawa T; Nishimura T; Ando M; Sawada JI Interaction of irinotecan (CPT-11) and its active metabolite 7- ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes	0	0
12823	10	12778 2002 DRUG METABOLISM AND DISPOSITION 30(6):701-708 Mei Q; Tang CY; Lin Y; Rushmore TH; Shou MG Inhibition kinetics of monoclonal antibodies against cytochromes P450	3	0
12824	6	12780 2002 DRUG METABOLISM AND DISPOSITION 30(8):904-910 Ishigami M; Takasaki W; Ikeda T; Komai T; Ito K; Sugiyama Y Sex difference in inhibition of in vitro mexazolam metabolism by various 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in rat liver microsomes	0	0
12825	15	12782 2002 DRUG METABOLISM AND DISPOSITION 30(9):1022-1028 Kalsotra A; Anakk S; Boehme CL; Strobel HW Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats	3	0
12826	8	12783 2002 DRUG METABOLISM AND DISPOSITION 30(9):1029-1034 El-Sankary W; Bombail V; Gibson GG; Plant N Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element	4	0
12827	16	12785 2002 DRUG METABOLISM AND DISPOSITION 30(12):1491-1496 Shih PS; Huang JD Pharmacokinetics of midazolam and 1 '-hydroxymidazolam in Chinese with different CYP3A5 genotypes	1	0
12828	15	12786 2002 DRUG METABOLISM REVIEWS 34(1-2):69-82 Lewis DFV; Modi S; Dickins M Structure-activity relationship for human cytochrome P450 substrates and inhibitors	5	0
12829	55	12788 2002 DRUG METABOLISM REVIEWS 34(3):451-477 Hlavica P N-oxidative transformation of free and N-substituted amine functions by cytochrome P450 as means of bioactivation and detoxication	0	0
12830	15	12789 2002 DRUG METABOLISM REVIEWS 34(3):667-676 Kamataki T; Fujita K; Nakayama K; Yamazaki Y; Miyamoto M; Ariyoshi N Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: Application of genetically engineered Salmonella expressing human CYP	0	0
12831	8	12790 2002 DRUGS & AGING 19(4):299-320 Spina E; Scordo MG Clinically significant drug interactions with antidepressants in the elderly	2	0
12832	5	12791 2002 ENDOCRINE RESEARCH 28(4):435-441 Johnson EF; Wester MR; Stout CD The structure of microsomal cytochrome p450 2C5: A steroid and drug metabolizing enzyme	1	0
12833	33	12792 2002 ENDOCRINE REVIEWS 23(5):687-702 Kliewer SA; Goodwin B; Willson TM The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism	2	0
12834	11	12794 2002 ENDOCRINOLOGY 143(12):4665-4672 Arlt W; Martens JWM; Song MS; Wang JT; Auchus RJ; Miller WL Molecular evolution of adrenarche: Structural and functional analysis of P450c17 from four primate species	1	0
12835	5	12795 2002 ENVIRONMENTAL HEALTH PERSPECTIVES 110():451-488 Bostrom CE; Gerde P; Hanberg A; Jernstrom B; Johansson C; Kyrklund T; Rannug A; Tornqvist M; Victorin K; Westerholm R Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air	5	0
12836	2	12796 2002 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 21(3):527-531 Tavera-Mendoza L; Ruby S; Brousseau P; Fournier M; Cyr D; Marcogliese D Response of the amphibian tadpole (Xenopus laevis) to atrazine during sexual differentiation of the testis	4	0
12837	10	12797 2002 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 21(9):1845-1853 Hawkins SA; Billiard SM; Tabash SP; Brown RS; Hodson PV Altering cytochrome p4501a activity affects polycyclic aromatic hydrocarbon metabolism and toxicity in rainbow trout (Oncorhynchus mykiss)	0	0
12838	6	12798 2002 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 21(10):2027-2033 Ziccardi MH; Gardner IA; Denison MS Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons	1	0
12839	5	12799 2002 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 11(1):1-7 Ikeda M; Inukai N; Mitsui T; Sone H; Yonemoto J; Tohyama C; Tomita T Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats	0	0
12840	5	12800 2002 EPILEPSIA 43():37-44 Spina E; Perucca E Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs	1	0
12841	11	12801 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(7):1799-1805 Kisselev P; Schwarz D; Platt KL; Schunck WH; Roots I Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes	1	0
12842	20	12802 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(8):2075-2082 Kitazume T; Tanaka A; Takaya N; Nakamura A; Matsuyama S; Suzuki T; Shoun H Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system	0	0
12843	15	12804 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(22):5608-5616 Swart AC; Kolar NW; Lombard N; Mason JI; Swart P Baboon cytochrome P450 17 alpha-hydroxylase/17,20-lyase (CYP17) - Characterization of the adrenal microsomal and cloned enzymes	1	0
12844	6	12805 2002 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 58(5):333-337 Xu P; Huang SL; Zhu RH; Han XM; Zhou HH Phenotypic polymorphism of CYP2A6 activity in a Chinese population	0	0
12845	18	12806 2002 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 58(5):357-365 Sy SKB; Ciaccia A; Li W; Roberts EA; Okey A; Kalow W; Tang BK Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression	1	0
12846	2	12807 2002 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 27(2):107-111 Cui ZF; He P; Luo M; Xia SQ; Wu MC Phenacetin O-deethylation in extrahepatic tissues of rats	0	0
12847	5	12808 2002 EUROPEAN JOURNAL OF ENDOCRINOLOGY 147(6):717-725 Xita N; Georgiou I; Tsatsoulis A The genetic basis of polycystic ovary syndrome	0	0
12848	8	12809 2002 EUROPEAN JOURNAL OF PHARMACOLOGY 449(1-2):61-69 Costa B; Parolaro D; Colleoni M Chronic treatment with the endocannabinoid anandamide increases cytochrome P450 metabolizing system in the rat	0	0
12849	1	12810 2002 EXPERIMENTAL BIOLOGY AND MEDICINE 227(8):561-569 Dmitrieva RI; Doris PA Cardiotonic steroids: Potential endogenous sodium pump ligands with diverse function	1	0
12850	14	12811 2002 FASEB JOURNAL 16(12):1537-1549 Thum T; Borlak J Testosterone, cytochrome P450, and cardiac hypertrophy	2	0
12851	6	12812 2002 FEBS LETTERS 512(1-3):121-124 Rastogi S; Das M; Khanna SK A novel approach to study the activity and stoichiometry simultaneously for microsomal pentoxyresorufin-O-dealkylase reaction	0	0
12852	6	12813 2002 FEBS LETTERS 528(1-3):90-94 Matsunaga I; Sumimoto T; Ayata M; Ogura H Functional modulation of a peroxygenase cytochrome P450: novel insight into the mechanisms of peroxygenase and peroxidase enzymes	0	0
12853	1	12814 2002 FEMS YEAST RESEARCH 2(2):123-135 Gurvitz A; Hartig A; Ruis H; Hamilton B; de Couet HG Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster	0	0
12854	7	12815 2002 FOOD AND CHEMICAL TOXICOLOGY 40(1):53-63 Laurenzana EM; Weis CC; Bryant CW; Newbold R; Delclos KB Effect of dietary administration of genistein, nonylphenol or ethinyl estradiol on hepatic testosterone metabolism, cytochrome P-450 enzymes, and estrogen receptor alpha expression	1	0
12855	9	12816 2002 FOOD AND CHEMICAL TOXICOLOGY 40(11):1685-1692 Jeong HG; Kim JY Effects of o,p '-DDT on the 2,3,7,8-tetrachlorodibenzo-p- dioxin-inducible CYP1A1 expression in murine Hepa-lc1c7 cells	0	0
12856	2	12817 2002 FREE RADICAL BIOLOGY AND MEDICINE 32(8):702-711 Navarro-Antolin J; Lopez-Munoz MJ; Soria J; Lamas S Superoxide limits cyclosporine-A-induced formation of peroxynitrite in endothelial cells	2	0
12857	7	12818 2002 FUNGAL GENETICS AND BIOLOGY 35(2):135-146 Fraser JA; Davis MA; Hynes MJ The genes gmdA, encoding an amidase, and bzuA, encoding a cytochrome P450, are required for benzamide utilization in Aspergillus nidulans	0	0
12858	14	12819 2002 GENE 297(1-2):179-187 Cui XM; Strobel HW Cloning and characterization of the rat cytochrome P4504F5 (CYP4F5) gene	0	0
12859	3	12820 2002 GENE 299(1-2):235-243 Carre W; Bourneuf E; Douaire M; Diot C Differential expression and genetic variation of hepatic messenger RNAs from genetically lean and fat chickens	1	0
12860	5	12822 2002 GENERAL AND COMPARATIVE ENDOCRINOLOGY 126(3):279-286 Vilchis F; Chavez B; Larrea F; Timossi C; Montiel F The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus)	0	0
12861	1	12824 2002 HAEMOPHILIA 8(3):221-229 Evatt BL; Farrugia A; Shapiro AD; Wilde JT Haemophilia 2002: emerging risks of treatment	2	0
12862	1	12825 2002 HEPATOLOGY 35(3):732-733 Kullak-Ublick GA; Jung D; Hagenbuch B; Meier PJ Organic anion transporting polypeptides, cholestasis, and nuclear receptors	0	0
12863	2	12826 2002 HEPATOLOGY 35(6):1351-1359 Kamiya A; Kojima N; Kinoshita T; Sakai Y; Miyaijma A Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: Induction of tryptophan oxygenase	2	0
12864	11	12827 2002 HORMONE RESEARCH 57(5-6):145-152 Meinhardt U; Mullis PE The aromatase cytochrome P-450 and its clinical impact	3	0
12865	9	12828 2002 HUMAN & EXPERIMENTAL TOXICOLOGY 21(1):17-23 Eke BC; Iscan M Effects of cigarette smoke with different tar contents on hepatic and xenobiotic metabolizing pulmonary enzymes in rats	0	0
12866	5	12829 2002 HUMAN MUTATION 20(6):463-472 Nebert DW Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes	0	0
12867	9	12831 2002 INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 39(3):191-196 Rastogi S; Khanna SK; Das M A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450IIB 1/2: Comparison with fluorometric assay	1	0
12868	12	12832 2002 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):303-309 He H; Chen AC; Davey RB; Ivie GW Molecular cloning and nucleotide sequence of a new P450 gene, CYP319A1, from the cattle tick, Boophilus microplus	0	0
12869	7	12833 2002 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):311-320 Li XC; Berenbaum MR; Schuler MA Cytochrome P450 and actin genes expressed in Helicoverpa zea and Helicoverpa armigera: paralogy/orthology identification, gene conversion and evolution	4	0
12870	12	12834 2002 INSECT MOLECULAR BIOLOGY 11(3):273-281 Maibeche-Coisne M; Jacquin-Joly E; Francois MC; Nagnan-Le Meillour P cDNA cloning of biotransformation enzymes belonging to the cytochrome P450 family in the antennae of the noctuid moth Mamestra brassicae	0	0
12871	12	12835 2002 INSECT MOLECULAR BIOLOGY 11(5):409-418 Ranson H; Nikou D; Hutchinson M; Wang X; Roth CW; Hemingway J; Collins FH Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae	2	0
12872	1	12836 2002 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 31(2):250-251 Tesiorowski AM; Harris M; Chan KJ; Thompson CR; Montaner JSG Anaerobic threshold and random venous lactate levels among HIV- positive patients on antiretroviral therapy	1	0
12873	1	12837 2002 JOURNAL OF ADVERTISING RESEARCH 42(2):80-92 Nelson MR Recall of brand placements in computer/video games	0	0
12874	4	12838 2002 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 50(2):378-383 Wu CC; Sheen LY; Chen HW; Kuo WW; Tsai SJ; Lii CK Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats	4	0
12875	3	12839 2002 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 50(12):3533-3539 Kubo I; Masuoka N; Xiao P; Haraguchi H Antioxidant activity of dodecyl gallate	0	0
12876	3	12841 2002 JOURNAL OF BACTERIOLOGY 184(11):2963-2968 Kumon Y; Sasaki Y; Kato I; Takaya N; Shoun H; Beppu T Codenitrification and denitrification are dual metabolic pathways through which dinitrogen evolves from nitrate in Streptomyces antibioticus	1	0
12877	10	12842 2002 JOURNAL OF BACTERIOLOGY 184(14):3898-3908 Roberts GA; Grogan G; Greter A; Flitsch SL; Turner NJ Identification of a new class of cytochrome P450 from a Rhodococcus sp.	3	0
12878	10	12843 2002 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 16(2):84-95 Seubert JM; Sinal CJ; Bend JR Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat	0	0
12879	16	12845 2002 JOURNAL OF BIOCHEMISTRY 131(1):71-78 Furukawa M; Okubo T; Ogino M; Yamazaki T; Shimada M; Nagata K; Yamazoe Y Adenovirus vector-mediated reporter system for in vivo analyses of human CYP3A4 gene activation	0	0
12880	8	12848 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(27):24000-24005 Lamb DC; Skaug T; Song HL; Jackson CJ; Podust LM; Waterman MR; Kell DB; Kelly DE; Kelly SL The cytochrome p450 complement (CYPome) of Streptomyces coelicolor A3(2)	6	0
12881	3	12849 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26356-26363 Min GS; Kemper JK; Kemper B Glucocorticoid receptor-interacting protein 1 mediates ligand- independent nuclear translocation and activation of constitutive androstane receptor in vivo	1	0
12882	17	12850 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(31):27725-27732 Hawkes DB; Adams GW; Burlingame AL; de Montellano PRO; De Voss JJ Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization	2	0
12883	23	12851 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(32):28351-28363 Coon MJ Enzyme ingenuity in biological oxidations: A trail leading to cytochrome P450	0	0
12884	11	12853 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(37):33842-33847 Zhang L; Kudo T; Takaya N; Shoun H The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH	1	0
12885	15	12855 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(49):46959-46965 Jackson CJ; Lamb DC; Marezylo TH; Warrilow AGS; Manning NJ; Lowe DJ; Kelly DE; Kelly SL A novel sterol 14 alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily	0	0
12886	8	12857 2002 JOURNAL OF BIOTECHNOLOGY 95(3):257-268 Jose J; Bernhardt R; Hannemann F Cellular surface display of dimeric Adx and whole cell P450- mediated steroid synthesis on E-coli	2	0
12887	8	12858 2002 JOURNAL OF CELLULAR BIOCHEMISTRY 86(3):440-450 Sterling KA; Cutroneo KR Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: Basement membrane-mediated apoptosis	0	0
12888	12	12860 2002 JOURNAL OF CHILD NEUROLOGY 17():S85-S93 Glauser TA Advancing the medical management of epilepsy: Disease modification and pharmacogenetics	0	0
12889	12	12863 2002 JOURNAL OF ENDOCRINOLOGY 175(3):779-792 Depreter M; Vandesompele J; Espeel M; Speleman F; Roels F Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications	1	0
12890	7	12864 2002 JOURNAL OF HEALTH SCIENCE 48(2):118-125 Hirano Y; Uehara M; Saeki K; Kato T; Takahashi K; Mizutani T The influence of quinolines on coumarin 7-hydroxylation in bovine liver microsomes and human CYP2A6	1	0
12891	3	12865 2002 JOURNAL OF HEALTH SCIENCE 48(4):346-349 Tanaka H; Hirayama I; Takehana M; Kobayashi S; Tamura H Cytochrome P450 expression in rat ocular tissues and its induction by phenobarbital	0	0
12892	4	12866 2002 JOURNAL OF HEPATOLOGY 36(1):72-77 Seo MY; Lee SM Protective effect of low dose of ascorbic acid on hepatobiliary function in hepatic ischemia/reperfusion in rats	2	0
12893	24	12867 2002 JOURNAL OF HUMAN GENETICS 47(8):419-444 Saito S; Iida A; Sekine A; Ogawa C; Kawauchi S; Higuchi S; Ohno M; Nakamura Y 906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese population	1	0
12894	30	12868 2002 JOURNAL OF INORGANIC BIOCHEMISTRY 91(4):502-514 Lewis DFV Modelling human cytochromes P450 involved in drug metabolism from the CYP2C5 crystallographic template	2	0
12895	17	12869 2002 JOURNAL OF INORGANIC BIOCHEMISTRY 91(4):515-526 Fuziwara S; Sagami I; Rozhkova E; Craig D; Noble MA; Munro AW; Chapman SK; Shimizu T Catalytically functional flavocytochrome chimeras of P450BM3 and nitric oxide synthase	1	0
12896	1	12871 2002 JOURNAL OF INVERTEBRATE PATHOLOGY 79(1):51-58 Ranasinghe C; Akhurst RJ Matrix assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) for detecting novel Bt toxins	1	0
12897	14	12874 2002 JOURNAL OF LIPID RESEARCH 43(9):1563-1578 Newman JW; Watanabe T; Hammock BD The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS	0	0
12898	20	12875 2002 JOURNAL OF MEDICINAL CHEMISTRY 45(10):1983-1993 de Groot MJ; Alex AA; Jones BC Development of a combined protein and pharmacophore model for cytochrome P4502C9	6	0
12899	18	12877 2002 JOURNAL OF NEUROCHEMISTRY 82(6):1376-1387 Miksys S; Rao Y; Hoffmann E; Mash DC; Tyndale RF Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics	5	0
12900	4	12878 2002 JOURNAL OF PAIN AND SYMPTOM MANAGEMENT 23(3):256-265 Cheng C; Roemer-Becuwe C; Pereira J When midazolam fails	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12901	4	12879 2002 JOURNAL OF PARASITOLOGY 88(1):163-170 Lyddiard JRA; Whitfield PJ; Bartlett A Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae)	0	0
12902	13	12880 2002 JOURNAL OF PHARMACEUTICAL SCIENCES 91(4):952-963 Nakajima M; Tane K; Nakamura S; Shimada N; Yamazaki H; Yokoi T Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: Effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities	3	0
12903	12	12881 2002 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 47(3):143-151 Cui X; Palamanda J; Norton L; Thomas A; Lau YY; White RE; Cheng KC A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction	0	0
12904	11	12883 2002 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 300(2):417-420 Chen CP; Thakker DR The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome P450-mediated metabolism of xenobiotics	0	0
12905	12	12884 2002 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 303(3):945-951 Kondraganti SR; Jiang WW; Moorthy B Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CP1A2 gene	0	0
12906	1	12885 2002 JOURNAL OF PROTEIN CHEMISTRY 21(2):97-104 Lorrai A; Padiglia A; Medda R; Bellelli A; Arcovito A; Floris G Aminoglycosides as substrates and inhibitors of peroxidases: A possible role of these antibiotics against myeloperoxidase- dependent cytotoxicity	0	0
12907	13	12886 2002 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 80(3):273-290 Morfin R Involvement of steroids and cytochromes P-450 species in the triggering of immune defenses	1	0
12908	6	12888 2002 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124(7):1430-1437 Guallar V; Harris DL; Batista VS; Miller WH Proton-transfer dynamics in the activation of cytochrome P450eryF	7	0
12909	3	12890 2002 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 124(43):12682-12683 Puchkaev AV; Wakagi T; de Montellano PRO CYP119 plus a Sultolobus tokodaii strain 7 ferredoxin and 2- oxoacid : ferredoxin oxidoreductase constitute a high- temperature cytochrome P450 catalytic system	0	0
12910	1	12891 2002 JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS (3):449-457 Perry CB; Chick T; Ntlokwana A; Davies G; Marques HM The co-ordination of ligands by iron porphyrins: a comparison of ligand binding by myoglobin from sperm whale and the haem undecapeptide from cytochrome c	1	0
12911	3	12892 2002 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A 65(17):1247-1260 Ma JYC; Yang HM; Barger MW; Siegel PD; Zhong BZ; Kriech AJ; Castranova V Alteration of pulmonary cytochrome P-450 system: Effects of asphalt fume condensate exposure	1	0
12912	2	12895 2002 KOREAN JOURNAL OF GENETICS 24(4):335-342 Park KS; Park MJ; Mok JW Genetic polymorphisms of CYPB1, COMT and GSTs genes in Koreans	0	0
12913	5	12897 2002 LEUKEMIA 16(10):1940-1958 Gallagher RE Retinoic acid resistance in acute promyelocytic leukemia	3	0
12914	3	12898 2002 LIPIDS 37(12):1163-1170 Gibbons GF The role of cytochrome P450 in the regulation of cholesterol biosynthesis	0	0
12915	4	12899 2002 LIPIDS 37(12):1187-1191 Lardy H; Marwah A; Marwah P Transformations of DHEA and its metabolites by rat liver	0	0
12916	2	12900 2002 MAGNETIC RESONANCE IN MEDICINE 48(6):965-972 Winalski CS; Shortkroff S; Mulkern RV; Schneider E; Rosen GM Magnetic resonance relaxivity of dendrimer-linked nitroxides	1	0
12917	2	12901 2002 MAMMALIAN GENOME 13(9):515-523 Narayanan RA; Rink A; Beattie CW; Hu WS Differential gene expression analysis during porcine hepatocyte spheroid formation	0	0
12918	14	12903 2002 MOLECULAR ENDOCRINOLOGY 16(8):1864-1880 Ben-Zimra M; Koler M; Orly J Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: Activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element	1	0
12919	7	12904 2002 MOLECULAR PHARMACOLOGY 61(4):795-799 Raffalli-Mathieu F; Glisovic T; Ben-David Y; Lang MA Heterogeneous nuclear ribonucleoprotein A1 and regulation of the xenobiotic-inducible gene Cyp2a5	4	0
12920	31	12905 2002 MOLECULAR PHARMACOLOGY 61(4):840-852 King LM; Ma JX; Srettabunjong S; Graves J; Bradbury JA; Li LP; Spiecker M; Liao JK; Mohrenweiser H; Zeldin DC Cloning of CYP2J2 gene and identification of functional polymorphisms	1	0
12921	13	12906 2002 MOLECULAR PHARMACOLOGY 61(4):892-904 Zangar RC; Kimzey AL; Okita JR; Wunschel DS; Edwards RJ; Kim H; Okita RT Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway	4	0
12922	9	12908 2002 MOLECULAR PHARMACOLOGY 62(3):737-746 Ferguson SS; Lecluyse EL; Negishi M; Goldstein JA Regulation of human CYP2C9 by the constitutive androstane receptor: Discovery of a new distal binding site	3	0
12923	10	12909 2002 MOLECULAR PHARMACOLOGY 62(5):1061-1067 Meyer RP; Podvinec M; Meyer UA Cytochrome P450CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme	0	0
12924	9	12910 2002 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 499(2):155-161 Chen N; Whitehead SE; Caillat AW; Gavit K; Isphording DR; Kovacevic D; McCreary MB; Hoffman SMG Identification and cross-species comparisons of CYP2F subfamily genes in mammals	1	0
12925	6	12912 2002 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 517(1-2):135-145 Gabelova A; Farakasova T; Bacova G; Robichova S Mutagenicity of 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in genetically engineered Chinese hamster V79 cell lines stably expressing cytochrome P450	0	0
12926	2	12913 2002 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 519(1-2):163-170 Vian L; Yusuf AT; Guyomard C; Cano JP The Liverbeads (R) as a tool for the comet assay	0	0
12927	5	12914 2002 MYCOLOGICAL RESEARCH 106():1171-1178 Albertini C; Thebaud G; Fournier E; Leroux P Eburicol 14 alpha-demethylase gene (CYP51) polymorphism and speciation in Botrytis cinerea	0	0
12928	27	12915 2002 NATURAL PRODUCT REPORTS 19(4):477-493 de Montellano PRO; De Voss JJ Oxidizing species in the mechanism of cytochrome P450	6	0
12929	19	12917 2002 NATURE REVIEWS DRUG DISCOVERY 1(4):259-266 Willson TM; Kliewer SA PXR, CAR and drug metabolism	7	0
12930	3	12918 2002 NEUROLOGY 58(10):1525-1532 Parkinson RB; Hopkins RO; Cleavinger HB; Weaver LK; Victoroff J; Foley JF; Bigler ED White matter hyperintensities and neuropsychological outcome following carbon monoxide poisoning	0	0
12931	6	12919 2002 NITRIC OXIDE, PT D 359():379-389 Daiber A; Ullrich V Peroxynitrite reactions with heme and heme-thiolate (P450) proteins	1	0
12932	15	12920 2002 ONCOLOGIST 7(6):516-530 Kruijtzer CMF; Beijnen JH; Schellens JHM Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: An overview	0	0
12933	1	12922 2002 ORAL ONCOLOGY 38(5):486-490 Hahn M; Hagedorn G; Kuhlisch E; Schackert HK; Eckelt U Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer	0	0
12934	7	12923 2002 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 73(2):74-86 Yoon KS; Nelson JO; Clark JM Selective induction of abamectin metabolism by dexamethasone, 3-methylcholanthrene, and phenobarbital in Colorado potato beetle, Leptinotarsa decemlineata (Say)	2	0
12935	10	12924 2002 PHARMACEUTICAL RESEARCH 19(12):1788-1800 Ekins S; Mirny L; Schuetz EG A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXR alpha, and LXR beta	2	0
12936	15	12925 2002 PHARMACOGENETICS 12(5):367-374 Lo-Guidice JM; Allorge D; Cauffiez C; Chevalier D; Lafitte JJ; Lhermitte M; Broly F Genetic polymorphism of the human cytochrome P450CYP4B1: evidence for a non-functional allelic variant	3	0
12937	3	12926 2002 PHARMACOGENETICS 12(6):459-463 Gemignani F; Landi S; Vivant F; Zienolddiny S; Brennan P; Canzian F A catalogue of polymorphisms related to xenobiotic metabolism and cancer susceptibility	1	0
12938	5	12928 2002 PLANT JOURNAL 32(4):495-508 Hong Z; Ueguchi-Tanaka M; Shimizu-Sato S; Inukai Y; Fujioka S; Shimada Y; Takatsuto S; Agetsuma M; Yoshida S; Watanabe Y; Uozu S; Kitano H; Ashikari M; Matsuoka M Loss-of-function of a rice brassinosteroid biosynthetic enzyme, C-6 oxidase, prevents the organized arrangement and polar elongation of cells in the leaves and stem	1	0
12939	15	12929 2002 PLANT PHYSIOLOGY 130(1):179-189 Didierjean L; Gondet L; Perkins R; Lau SMC; Schaller H; O'Keefe DP; Werck-Reichhart D Engineering herbicide metabolism in tobacco and Arabidopsis with CYP76B1, a cytochrome P450 enzyme from Jerusalem artichoke	1	0
12940	4	12931 2002 PLANT PHYSIOLOGY 130(3):1152-1161 Mori M; Nomura T; Ooka H; Ishizaka M; Yokota T; Sugimoto K; Okabe K; Kajiwara H; Satoh K; Yamamoto K; Hirochika H; Kikuchi S Isolation and characterization of a rice dwarf mutant with a defect in brassinosteroid biosynthesis	1	0
12941	19	12932 2002 PLANT PHYSIOLOGY 130(4):1837-1851 Ro DK; Ehlting J; Douglas CJ Cloning, functional expression, and subcellular localization of multiple NADPH-cytochrome P450 reductases from hybrid poplar	0	0
12942	7	12933 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(4):2222-2227 Davis BB; Thompson DA; Howard LL; Morisseau C; Hammock BD; Weiss RH Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation	3	0
12943	1	12934 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(11):7484-7489 Alesci S; Ramsey WJ; Bornstein SR; Chrousos GP; Hornsby PJ; Benvenga S; Trimarchi F; Ehrhart-Bornstein M Adenoviral vectors can impair adrenocortical steroidogenesis: Clinical implications for natural infections and gene therapy	2	0
12944	7	12935 2002 PROGRESS IN NATURAL SCIENCE 12(8):598-602 Wang H; Lin L; Lu ZY; Wang DW Up-regulation of endothelial nitric oxide synthase by cytochrome P450 arachidonic acid epoxygenase BM(3)F87V	0	0
12945	39	12936 2002 PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9():345-362 Kikuta Y; Kusunose E; Kusunose M Prostaglandin and leukotriene omega-hydroxylases	2	0
12946	1	12937 2002 PROSTAGLANDINS & OTHER LIPID MEDIATORS 68-9():471-482 Murphy RC; Zarini S Glutathione adducts of oxyeicosanoids	0	0
12947	4	12938 2002 PROSTAGLANDINS & OTHER LIPID MEDIATORS 70(1-2):31-37 Chevalier D; Allorge D; Lo-Guidice JM; Cauffiez C; Lepetit C; Migot-Nabias F; Kenani A; Lhermitte M; Broly F Sequence analysis, frequency and ethnic distribution of VNTR polymorphism in the 5 '-untranslated region of the human prostacyclin synthase gene (CYP8A1)	0	0
12948	7	12940 2002 PROTEOMICS 2(6):713-722 Galeva N; Altermann M Comparison of one-dimensional and two-dimensional gel electrophoresis as a separation tool for proteomic analysis of rat liver microsomes: Cytochromes P450 and other membrane proteins	6	0
12949	10	12941 2002 RECENT PROGRESS IN HORMONE RESEARCH, VOL 57 57():317-338 Simpson ER; Dowsett M Aromatase and its inhibitors: Significance for breast cancer therapy	3	0
12950	2	12942 2002 SCIENCE IN CHINA SERIES C-LIFE SCIENCES 45(5):512-517 Zhong L; Wang K; Tan J; Li W; Li SG Putative cytochrome P450 genes in rice genome (Oryza sativa L. ssp indica) and their EST evidence	0	0
12951	6	12943 2002 SCIENCE OF THE TOTAL ENVIRONMENT 300(1-3):37-49 Binet S; Pfohl-Leszkowicz A; Brandt H; Lafontaine M; Castegnaro M Bitumen fumes: review of work on the potential risk to workers and the present knowledge on its origin	0	0
12952	2	12944 2002 SEIKAGAKU 74(11):1317-1328 Suematsu M Gas biology: How do the gases conduct protein function in vivo?	0	0
12953	5	12945 2002 SEMINARS IN LIVER DISEASE 22(2):109-113 Farrell GC; Liddle C Drugs and the liver updated, 2002 - Foreword	1	0
12954	21	12946 2002 SEMINARS IN LIVER DISEASE 22(2):115-122 Liddle C; Goodwin B Regulation of hepatic drug metabolism: Role of the nuclear receptors PXR and CAR	5	0
12955	10	12947 2002 SEMINARS IN REPRODUCTIVE MEDICINE 20(3):249-254 Peter M Congenital adrenal hyperplasia: 11 beta-hydroxylase deficiency	0	0
12956	11	12948 2002 SEMINARS IN REPRODUCTIVE MEDICINE 20(3):277-283 Meinhardt U; Mullis PE The essential role of the aromatase/P450arom	0	0
12957	4	12950 2002 TOXICOLOGIC PATHOLOGY 30(6):620-650 Nyska A; Kohen R Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification	1	0
12958	6	12951 2002 TOXICOLOGY 175(1-3):15-25 Fadhel Z; Lu ZJ; Robertson LW; Glauert HP Effect of 3,3 ',4,5 '-tetrachlorobiphenyl and 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl on the induction of hepatic lipid peroxidation and cytochrome P-450 associated enzyme activities in rats	0	0
12959	0	12952 2002 TOXICOLOGY 178(1):6-7 Estabrook RW The cytochrome P450s and "reactive metabolites"	0	0
12960	8	12953 2002 TOXICOLOGY 181():255-260 Josephy PD Genetically-engineered bacteria expressing human enzymes and their use in the study of mutagens and mutagenesis	0	0
12961	8	12954 2002 TOXICOLOGY AND APPLIED PHARMACOLOGY 179(1):1-12 Andersen HR; Vinggaard AM; Rasmussen TH; Gjermandsen IM; Bonefeld-Jorgensen EC Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro	7	0
12962	5	12955 2002 TOXICOLOGY LETTERS 128(1-3):129-144 Klinger W; Lupp A; Karge E; Baumbach H; Eichhorn F; Feix A; Fuldner F; Gernhardt S; Knels L; Kost B; Mertens G; Werner F; Oettel M; Romer W; Schwarz S; Elger W; Schneider B Estradiol, testosterone,, dehydroepiandrosterone and androstenedione: novel derivatives and enantiomers. Interactions with rat liver microsomal cytochrome P450 and antioxidant/radical scavenger activities in vitro	2	0
12963	2	12956 2002 TRANSPLANT IMMUNOLOGY 10(4):255-258 Durak I; Kacmaz M; Cimen MYB; Buyukkocak S; Elgun S; Ozturk HS The effects of cyclosporine on antioxidant enzyme activities and malondialdehyde levels in rabbit hepatic tissues	0	0
12964	6	12958 2002 WORLD JOURNAL OF SURGERY 26(8):950-957 Musholt TJ; Klebs SHG; Musholt PB; Ellerkamp V; Klempnauer J; Hoffmann MW Transplantation of adrenal tissue fragments in a murine model: Functional capacities of syngeneic and allogeneic grafts	1	0
12965	8	12960 2002 XENOBIOTICA 32(6):521-534 Subrahmanyam V; Renwick AB; Walters DG; Price RJ; Tonelli AP; Lake BG Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms	0	0
12966	8	12961 2002 XENOBIOTICA 32(7):595-604 Johnson TN; Tanner MS; Tucker GT Developmental changes in the expression of enterocytic and hepatic cytochromes P4501A in rat	0	0
12967	5	12963 2002 XENOBIOTICA 32(11):985-996 Granhall C; Floby E; Nordmark A; Orzechowski A; Thorne A; Tybring G; Sohlenius-Sternbeck AK Characterization of testosterone metabolism and 7- hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months	0	0
12968	13	12964 2002 XENOBIOTICA 32(12):1063-1077 Lesigiarska I; Pajeva I; Yanev S Quantitative structure-activity relationship (QSAR) and three- dimensional QSAR analysis of a series of xanthates as inhibitors and inactivators of cytochrome P4502B1	0	0
12969	11	12965 2003 ACTA BIOCHIMICA POLONICA 50(2):405-413 Rauchova H; Drahota Z; Rauch P; Fato R; Lenaz G Coenzyme Q releases the inhibitory effect of free fatty acids on mitochondrial glycerophosphate dehydrogenase	0	0
12970	15	12966 2003 ADVANCED SYNTHESIS & CATALYSIS 345(6-7):802-810 Maurer SC; Schulze H; Schmid RD; Urlacher V Immobilisation of P450BM-3 and an NADP(+) cofactor recycling system: Towards a technical application of heme-containing monooxygenases in fine chemical synthesis	0	0
12971	6	12967 2003 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 284(4):R1053-R1054 Skott O Androgen-induced activation of 20-HETE production may contribute to gender differences in blood pressure regulation	0	0
12972	3	12968 2003 ANALYTICAL LETTERS 36(8):1475-1491 Asai R; Nakamura C; Ikebukuro K; Karube I; Miyake J A Bioassay to detect contaminant-induced messenger RNA using a transcriptomic approach: Detection of RT-PCR-amplified single- stranded DNA based on the SPR sensor in cyanobacteria	0	0
12973	26	12969 2003 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 43():1-30 Conney AH Induction of drug-metabolizing enzymes: A path to the discovery of multiple cytochromes P450	0	0
12974	48	12970 2003 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 43():149-173 Ding XX; Kaminsky LS Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts	3	0
12975	6	12971 2003 ANTIOXIDANTS & REDOX SIGNALING 5(2):195-203 O'Donnell VB Free radicals and lipid signaling in endothelial cells	1	0
12976	15	12972 2003 AQUATIC TOXICOLOGY 62(1):67-78 Rees CB; McCormick SD; Vanden Heuvel JP; Li WM Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar)	0	0
12977	5	12973 2003 AQUATIC TOXICOLOGY 63(3):271-282 Cao ZJ; Tanguay RL; McKenzie D; Peterson RE; Aiken JM Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout	0	0
12978	7	12974 2003 ARCHIV DER PHARMAZIE 335(11-12):526-534 Haidar S; Hartmann RW C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17 alpha-hydroxylase-C17,20- lyase: Synthesis and biological evaluation	0	0
12979	10	12975 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):59-71 Guengerich FP Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions	0	0
12980	23	12976 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):113-126 Xue LL; Zgoda VG; Arison B; Correia MA Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase	0	0
12981	11	12977 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):134-144 Auchus RJ; Kumar AS; Boswell CA; Gupta MK; Bruce K; Rath NP; Covey DF The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21	1	0
12982	14	12978 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):145-152 Swart P; Lombard N; Swart AC; van der Merwe T; Murry BA; Nicol M; Mason JI Ovine steroid 17 alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme	0	0
12983	17	12979 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):197-206 Baldwin A; Huang ZQ; Jounaidi Y; Waxman DJ Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer	0	0
12984	15	12980 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 409(1):221-227 Bellamine A; Wang YR; Waterman MR; Dawson EP; Brown NJ; Capdevila JH Characterization of the CYNA11 gene, a second CYP4A gene in humans	1	0
12985	27	12981 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 411(2):223-234 Oleksiak MF; Wu S; Parker C; Qu W; Cox R; Zeldin DC; Stegeman JJ Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase	0	0
12986	1	12982 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 412(1):2-2 Klingenberg M The dragging emergence of the P450 cytochrome	0	0
12987	22	12983 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 412(1):77-89 Lee SJ; Buhler DR Cloning, tissue distribution, and functional studies of a new cytochrome P450 3A subfamily member, CYP3A45, from rainbow trout (Oncorhynchus mykiss) intestinal ceca	0	0
12988	21	12984 2003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 412(1):147-152 Mokashi V; Li L; Porter TD Cytochrome b5 reductase and cytochrome b5 support the CYP2E1- mediated activation of nitrosamines in a recombinant Ames test	0	0
12989	2	12985 2003 ARCHIVES OF MICROBIOLOGY 179(5):329-338 Mazoy R; Osorio CR; Toranzo AE; Lemos ML Isolation of mutants of Vibrio anguillarum defective in haeme utilisation and cloning of huvA, a gene coding for an outer membrane protein involved in the use of haeme as iron source	0	0
12990	6	12986 2003 ARCHIVES OF PHARMACAL RESEARCH 26(1):47-52 Lee WY; Lee SM The roles of Kupffer cells in hepatocellular dysfunction after femur fracture trauma in rats	0	0
12991	4	12987 2003 ARCHIVES OF TOXICOLOGY 77(3):138-144 Ohhira S; Watanabe M; Matsui H Metabolism of tributyltin and triphenyltin by rat, hamster and human hepatic microsomes	0	0
12992	15	12988 2003 ARCHIVES OF TOXICOLOGY 77(3):145-149 Haag M; Fautrel A; Guillouzo A; Frossard N; Pons F Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16 alpha-carbonitrile	0	0
12993	4	12989 2003 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 53(1):26-33 Washio T; Kohsaka K; Arisawa H; Masunaga H Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs	1	0
12994	15	12990 2003 BIOCHEMICAL JOURNAL 370():763-769 Marek CJ; Cameron GA; Elrick LJ; Hawksworth GM; Wright MC Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro	0	0
12995	21	12991 2003 BIOCHEMICAL JOURNAL 370():921-926 Flanagan JU; McLaughlin LA; Paine MJI; Sutcliffe MJ; Roberts GCK; Wolf CR Role of conserved Asp(293) of cytochrome P4502C9 in substrate recognition and catalytic activity	0	0
12996	15	12992 2003 BIOCHEMICAL JOURNAL 372():317-327 McLean KJ; Scrutton NS; Munro AW Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA	1	0
12997	8	12993 2003 BIOCHEMICAL PHARMACOLOGY 65(6):949-959 Fan LQ; Coley J; Miller RT; Cattley RC; Corton JC Opposing mechanisms of NADPH-cytochrome P450 oxidoreductase regulation by peroxisome proliferators	0	0
12998	4	12994 2003 BIOCHEMICAL PHARMACOLOGY 65(10):1583-1591 Imai K; Kudo N; Koyama M; Kawashima Y Effects of dehydroepiandrosterone on oleic acid accumulation in rat liver	0	0
12999	6	12995 2003 BIOCHEMICAL PHARMACOLOGY 65(10):1653-1661 Glisovic T; Soderberg M; Christian K; Lang M; Raffalli-Mathieu F Interplay between transcriptional and post-transcriptional regulation of Cyp2a5 expression	0	0
13000	17	12996 2003 BIOCHEMICAL PHARMACOLOGY 65(11):1817-1826 Joseph S; Rusling JF; Lvov YM; Friedberg T; Fuhr U An amperometric biosensor with human CYP3A4 as a novel drug screening tool	0	0

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