#	Cited nodes	Nodes / Authors	GCS	LCS
12101	2	11289 1998 JOURNAL OF HEART AND LUNG TRANSPLANTATION 17(11):1104-1112 Oelberg DA; Systrom DM; Markowitz DH; Zorb SL; Wright C; Wain JC; Ginns LC Exercise performance in cystic fibrosis before and after bilateral lung transplantation	6	0
12102	2	11291 1998 JOURNAL OF LEUKOCYTE BIOLOGY 64(3):322-330 Huang YI; Surichamorn W; Cao GL; Meng M; Pou S; Rosen GM; Salcedo TW; Strimpler A; Veale C; Bernstein PR; Bonuccelli CM Effect of trifluoromethyl ketone-based elastase inhibitors on neutrophil function in vitro	5	0
12103	6	11293 1998 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 5(1-4):371-377 Jezequel SG Microbial models of mammalian metabolism: uses and misuses (clarification of some misconceptions)	1	0
12104	1	11294 1998 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 5(1-4):379-384 Gilder V; Bunch AW The synthesis of 17 alpha-ethynylestradiol glucuronides by mammalian microsomes immobilised in hollow-fibres	2	0
12105	3	11302 1998 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 285(3):1233-1238 Ross AD; Dey I; Janes N; Israel Y Effect of antithyroid drugs on hydroxyl radical formation and alpha-1-proteinase inhibitor inactivation by neutrophils: Therapeutic implications	5	0
12106	7	11310 1998 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 66(1-2):1-10 Brodie AMH; Njar VCO Aromatase inhibitors in advanced breast cancer: Mechanism of action and clinical implications	28	0
12107	9	11312 1998 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120(30):7404-7410 Tschirret-Guth RA; Medzihradszky KF; de Montellano PRO Specific azidophenyldiazene hemoprotein active site probes. Cross-linking of the heme to His-64 in myoglobin	7	0
12108	3	11314 1998 JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 75(8):939-943 Piazza GJ; Foglia TA; Nunez A Enantioselective conversion of linoleate hydroperoxide to an alpha,beta-epoxy alcohol by niobium ethoxide	0	0
12109	11	11315 1998 JOURNAL OF THE INDIAN CHEMICAL SOCIETY 75(10-12):795-803 Chandra R; Aneja R Cytochrome P450 enzymes: Significance, multiplicity of isoforms, substrates, catalytic and regulatory mechanisms, physiological functions and clinical correlations	0	0
12110	2	11319 1998 MARINE ENVIRONMENTAL RESEARCH 46(1-5):21-24 Boyle SM; Greenberg RM; James MO Isolation of CYP2L2 and two other cytochrome P450 sequences from a spiny lobster, Panulirus argus, hepatopancreas cDNA library	0	0
12111	1	11320 1998 MEDIATORS OF INFLAMMATION 7(2):85-91 Longo WE; Damore LJ; Mazuski JE; Smith GS; Panesar N; Kaminski DL The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation	10	0
12112	6	11321 1998 MEDICAL SCIENCE RESEARCH 26(10):691-693 Ahmed RS; Pawar SS Effect of inducers on the hepatic microsomal mixed function oxidase system of female rats during food restriction	1	0
12113	11	11322 1998 MEDICINA CLINICA 111(12):465-470 Ladero JM; Garcia-Agundez JA; Benitez J Enzymatic polymorphisms and lung cancer	0	0
12114	1	11323 1998 MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS 62(3):807-+ Crickmore N; Zeigler DR; Feitelson J; Schnepf E; Van Rie J; Lereclus D; Baum J; Dean DH Revision of the nomenclature for the Bacillus thuringiensis pesticidal crystal proteins	134	0
12115	3	11327 1998 MOLECULAR AND GENERAL GENETICS 259(3):299-308 Olano C; Rodriguez AM; Michel JM; Mendez C; Raynal MC; Salas JA Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring	31	0
12116	23	11328 1998 MOLECULAR ASPECTS OF MEDICINE 19(3):155-+ Biason-Lauber A Molecular medicine of steroid hormone biosynthesis - Introduction	2	0
12117	4	11329 1998 MOLECULAR BIOLOGY 32(3):471-474 Sharipova GA; Gulyaeva LF; Lyakhovich VV Cytochromes P-4501A activity and mRNA level in liver and lungs of rats induced with various xenobiotics	0	0
12118	4	11331 1998 MOLECULAR CARCINOGENESIS 23(2):76-85 Pfohl-Leszkowicz A; Pinelli E; Bartsch H; Mohr U; Castegnaro M Sex- and strain-specific expression of cytochrome P450s in ochratoxin A-induced genotoxicity and carcinogenicity in rats	11	0
12119	1	11338 1998 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 402(1-2):321-329 von Borstel RC; Higgins JA Janus carcinogens and mutagens	8	0
12120	8	11341 1998 MYCOSES 41():32-38 Vanden Bossche H; Koymans L Cytochromes P450 in fungi	9	0
12121	98	11342 1998 NATURAL PRODUCT REPORTS 15(6):653-696 Brown GD The biosynthesis of steroids and triterpenoids	6	0
12122	9	11344 1998 NEUROCHEMICAL RESEARCH 23(2):227-233 Alexander JJ; Snyder A; Tonsgard JH Omega-oxidation of monocarboxylic acids in rat brain	3	0
12123	3	11346 1998 NEUROLOGY 51(6):1562-1566 Lovell MA; Xie C; Markesbery WR Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease	40	0
12124	1	11350 1998 NEW ZEALAND MEDICAL JOURNAL 111(1065):175-175 Brown S Recreational use of oxygen	0	0
12125	1	11352 1998 ONCOLOGY RESEARCH 10(10):491-498 Di Padova M; Barbieri R; Fanciulli M; Arcuri E; Floridi A Effect of local anesthetic ropivacaine on the energy metabolism of Ehrlich ascites tumor cells	1	0
12126	1	11354 1998 PANMINERVA MEDICA 40(4):343-344 Fierro G; Sanfilippo M; Cavalletti MV; Biancari F; Vilardi V Laparoscopic cholecystectomy in a patient with mitochondrial myopathy	0	0
12127	2	11355 1998 PESTICIDE SCIENCE 54(1):43-51 Vicente JAF; Santos MS; Vercesi AE; Madeira VMC Comparative effects of the herbicide dinitro-o-cresol on mitochondrial bioenergetics	1	0
12128	2	11358 1998 PHARMACOGENETICS 8(1):49-53 Durocher F; Morissette J; Simard J Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region	5	0
12129	5	11366 1998 PHARMACOLOGICAL RESEARCH 38(3):215-219 Janbaz KH; Saeed SA; Gilani AH An assessment of the potential of protopine to inhibit microsomal drug metabolising enzymes and prevent chemical- induced hepatotoxicity in rodents	0	0
12130	14	11368 1998 PHARMACOLOGY 56(2):71-79 Sharma MC; Sharma MR; Shapiro BH A comparison of cytochrome P-450-dependent testosterone 2 alpha-hydroxylase in rat (P-450 2C11) and mouse (P-4502 alpha)	1	0
12131	2	11370 1998 PHARMACOLOGY 57(6):286-294 Yoshimura T; Itoh S; Tsujikawa K; Yamada E; Ishii T; Iemura O; Kameda Y; Mimura T; Kohama Y Effect of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D- 3 on the expression of vitamin-D-responsive genes in vitamin-D- deficient mice	1	0
12132	3	11378 1998 PHYTOCHEMISTRY 49(2):387-394 Jiao Y; Davin LB; Lewis NG Furanofuran lignan metabolism as a function of seed maturation in Sesamum indicum: Methylenedioxy bridge formation	3	0
12133	6	11379 1998 PHYTOTHERAPY RESEARCH 12(2):89-93 Teel RW; Huynh H Effect of phytochemicals on cytochrome P450-linked alkoxyresorufin O-dealkylase activity	5	0
12134	2	11388 1998 PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 217(1):23-29 Subbiah MTR Mechanisms of cardioprotection by estrogens	34	0
12135	14	11390 1998 PSYCHOPHARMAKOTHERAPIE 5(1):8-18 Eckert A; Reiff J; Muller WE Drug interactions with antidepressants. Advantages of the selective serotonin reuptake inhibitor citalopram	6	0
12136	1	11391 1998 RECENT PROGRESS IN HORMONE RESEARCH, VOL 53 53():341-350 Glorieux FH; St-Arnaud R Molecular cloning of (25-OH D)-1 alpha-hydroxylase: An approach to the understanding of vitamin D pseudo-deficiency	4	0
12137	9	11392 1998 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 99(1):17-22 Ohmori S; Sakamoto Y; Nakasa H; Kitada M Nucleotide and amino acid sequences of the monkey P450 2B gene subfamily	3	0
12138	5	11394 1998 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 100(3):265-271 Doi H; Masubuchi Y; Narimatsu S; Nishigaki R; Horie T Salicylic acid-induced lipid peroxidation in rat liver microsomes	3	0
12139	7	11395 1998 SARSIA 83(3):225-241 Arukwe A; Goksoyr A Xenobiotics, xenoestrogens and reproduction disturbances in fish	9	0
12140	2	11396 1998 SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE 25():45-56 Witkamp RF; Monshouwer M Pharmacokinetics in vivo and in vitro in swine	3	0
12141	3	11398 1998 SOUTH AFRICAN JOURNAL OF SCIENCE 94(6):303-304 Farombi EO; Emerole GO Interference of common antimalarial drugs with some hepatic microsomal components and drug metabolism: potential implications for toxicity	5	0
12142	1	11401 1998 TETRAHEDRON 54(16):3971-3982 Mozhaev VV; Budde CL; Rich JO; Usyatinsky AY; Michels PC; Khmelnitsky YL; Clark DS; Dordick JS Regioselective enzymatic acylation as a tool for producing solution-phase combinatorial libraries	24	0
12143	4	11403 1998 TOXICOLOGICAL SCIENCES 46(1):185-196 Ratra GS; Cottrell S; Powell CJ Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene	3	0
12144	4	11407 1998 TOXICOLOGY 131(2-3):99-107 Hong JT; Glauert HP Stimulation of the DNA binding activity of AP-1 by the peroxisome proliferator ciprofibrate and eicosanoids in cultured rat hepatocytes	7	0
12145	5	11411 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 149(2):217-225 Ammann P; Laethem CL; Kedderis GL Chloroform-induced cytolethality in freshly isolated male B6C3F(1) mouse and F-344 rat hepatocytes	5	0
12146	2	11415 1998 TOXICOLOGY IN VITRO 12(4):431-444 Fahrig R; Rupp M; Steinkamp-Zucht A; Bader A Use of primary rat and human hepatocyte sandwich cultures for activation of indirect carcinogens: Monitoring of DNA strand breaks and gene mutations in co-cultured cells	4	0
12147	16	11417 1998 TOXICOLOGY LETTERS 94(2):115-125 Amacher DE; Schomaker SJ Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes	5	0
12148	13	11418 1998 TOXICOLOGY LETTERS 103():161-166 Gonzalez FJ The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption	0	0
12149	12	11421 1998 VOPROSY MEDITSINSKOI KHIMII 44(1):3-27 Archakov AI; Zgoda VG; Karuzina II Oxidative modification of cytochrome P450 and other macromolecules during turnover	1	0
12150	7	11422 1998 VOPROSY MEDITSINSKOI KHIMII 44(5):423-436 Shumyantseva VV; Moskvitina TL; Bulko TV; Archakov AI Alternative electron sources in cytochrome P450-catalyzed reactions.	1	0
12151	11	11430 1998 XENOBIOTICA 28(4):403-411 Inoue K; Yamazaki H; Shimada T Linkage between the distribution of mutations in the CYP2C18 and CYP2C19 genes in the Japanese and Caucasian	6	0
12152	6	11433 1998 XENOBIOTICA 28(8):759-766 Mae T; Hosoe K; Yamamoto T; Hidaka T; Ohashi T; Kleeman JM; Adams PE Effect of a new rifamycin derivative, rifalazil, on liver microsomal enzyme induction in rat and dog	4	0
12153	11	11438 1998 XENOBIOTICA 28(10):949-956 Carr BA; Franklin MR Drug-metabolizing enzyme induction by 2,2 '-dipyridyl, 1,7- phenanthroline, 7,8-benzoquinoline and oltipraz in mouse	1	0
12154	7	11439 1998 XENOBIOTICA 28(10):995-1004 Yamazaki H; Shimada T Formation in vitro of an inhibitory cytochrome P450 center dot Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes	3	0
12155	31	11443 1999 ADDICTION BIOLOGY 4(3):283-301 Cho AK; Narimatsu S; Kumagai Y Metabolism of drugs of abuse by cytochromes P450	1	0
12156	5	11445 1999 ADVANCES IN INORGANIC CHEMISTRY, VOL 47 47():83-157 Link TA The structures of Rieske and Rieske-type proteins	15	0
12157	5	11447 1999 AMERICAN JOURNAL OF MEDICINE 106(2):227-237 Gregg CR Drug interactions and anti-infective therapies	8	0
12158	1	11448 1999 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 277(6):E976-E983 Kashiwagi A; Shinozaki K; Nishio Y; Maegawa H; Maeno Y; Kanazawa A; Kojima H; Haneda M; Hidaka H; Yasuda H; Kikkawa R Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats	17	0
12159	7	11456 1999 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 277(5):F790-F796 Alonso-Galicia M; Falck JR; Reddy KM; Roman RJ 20-HETE agonists and antagonists in the renal circulation	24	0
12160	3	11457 1999 AMERICAN JOURNAL OF PREVENTIVE MEDICINE 16(2):122-133 Ellsworth DL; Sholinsky P; Jaquish C; Fabsitz RR; Manolio TA Coronary heart disease - At the interface of molecular genetics and preventive medicine	11	0
12161	2	11462 1999 ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION 18(7):725-747 Laudenbach V; Mantz J; Desmonts JM To understand molecular biology	0	0
12162	12	11464 1999 ANNALS OF CLINICAL BIOCHEMISTRY 36():722-729 van der Weide J; Steijns LSW Cytochrome P450 enzyme system: genetic polymorphisms and impact on clinical pharmacology	20	0
12163	2	11469 1999 ANTICANCER RESEARCH 19(3A):2095-2099 Huynh HT; Teel RW Effects of intragastrically administered Pycnogenol (R) on NNK metabolism in F344 rats	4	0
12164	1	11475 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 363(2):202-212 Xu G; Goodridge AG Function of a C-rich sequence in the polypyrimidine/polypurine tract of the promoter of the chicken malic enzyme gene depends on promoter context	4	0
12165	7	11480 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 367(2):322-332 Ripp SL; Itagaki K; Philpot RM; Elfarra AA Methionine S-oxidation in human and rabbit liver microsomes: Evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin-containing monooxygenase 3	7	0
12166	18	11489 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 372(1):189-196 Mankowski DC; Laddison KJ; Christopherson PA; Ekins S; Tweedie DJ; Lawton MP Molecular cloning, expression, and characterization of CYP2D17 from cynomolgus monkey liver	3	0
12167	4	11490 1999 ARCHIVES OF DERMATOLOGICAL RESEARCH 291(1):54-58 Baroni A; Ruocco V; De Paolis P; Cicatiello L; Esumi H; Tufano MA Ketoconazole inhibits lipopolysaccharide-induced activation of the nitric oxide synthase gene in the murine macrophage cell line J774	5	0
12168	17	11492 1999 ARCHIVES OF TOXICOLOGY 73(4-5):208-216 Iba MM; Fung J; Thomas PE; Park Y Constitutive and induced expression by pyridine and beta- naphthoflavone of rat CYP1A is sexually dimorphic	4	0
12169	8	11493 1999 ARCHIVES OF TOXICOLOGY 73(8-9):427-430 Bruning T; Abel J; Koch B; Lorenzen K; Harth V; Donat S; Sachinidis A; Vetter H; Bolt HM; Ko Y Real-time PCR-analysis of the cytochrome P4501B1 codon 432- polymorphism	4	0
12170	10	11494 1999 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 49(5):470-475 Muller-Enoch D Investigations on the role of cytochrome b(5) and divalent cations in the maximal nifedipine oxidase activity of human liver	1	0
12171	7	11495 1999 ATHEROSCLEROSIS 143(2):253-260 Aviram M; Kent UM; Hollenberg PF Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein	12	0
12172	4	11497 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 254(1):120-123 Lardy H; Henwood SM; Weeks CE An acute oral gavage study of 3 beta-acetoxyandrost-5-ene-7,17- dione (7-oxo-DHEA-acetate) in rats	4	0
12173	23	11502 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 258(1):32-38 Zhang YQ; Pernecky SJ Cumene hydroperoxide-supported demethylation reactions catalyzed by cytochrome P450 2B4 lacking the NH2-terminal sequence	1	0
12174	6	11506 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 263(2):392-397 Osada M; Ogura Y; Yasui H; Sakurai H Involvement of singlet oxygen in cytochrome P450-dependent substrate oxidations	4	0
12175	25	11508 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 264(2):413-418 Dauphin-Villemant C; Bocking D; Tom M; Maibeche M; Lafont R Cloning of a novel cytochrome P450 (CYP4C15) differentially expressed in the steroidogenic glands of an arthropod	6	0
12176	9	11509 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266(1):262-267 Gu J; Dudley C; Su T; Spink DC; Zhang QY; Moss RL; Ding XX Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa	5	0
12177	10	11511 1999 BIOCHEMICAL JOURNAL 338():499-505 Bagnaresi P; Thoiron S; Mansion M; Rossignol M; Pupillo P; Briat JF Cloning and characterization of a maize cytochrome-b(5) reductase with Fe3+-chelate reduction capability	7	0
12178	6	11513 1999 BIOCHEMICAL JOURNAL 339():695-703 Tilloy-Ellul A; Raffalli-Mathieu F; Lang MA Analysis of RNA-protein interactions of moose liver cytochrome P4502A5 mRNA	9	0
12179	6	11519 1999 BIOCHEMICAL PHARMACOLOGY 58(10):1547-1555 Lee SM; Cho TS; Kim DJ; Cha YN Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice - Role of NADH : quinone reductase	2	0
12180	23	11524 1999 BIOCHEMISTRY 38(19):6093-6103 Schalk M; Nedelkina S; Schoch G; Batard Y; Werck-Reichhart D Role of unusual amino acid residues in the proximal and distal heme regions of a plant P450, CYP73A1	6	0
12181	10	11528 1999 BIOCHEMISTRY 38(48):15853-15862 Sono M; Ledbetter AP; McMillan K; Roman LJ; Shea TM; Masters BSS; Dawson JH Essential thiol requirement to restore pterin- or substrate- binding capability and to regenerate native enzyme-type high- spin heme spectra in the Escherichia coli-expressed tetrahydrobiopterin-free oxygenase domain of neuronal nitric oxide synthase	8	0
12182	23	11529 1999 BIOCHEMISTRY-MOSCOW 64(2):136-152 Vinogradov AD; Gavrikova EV; Grivennikova VG; Zharova TV; Zakharova NV Catalytic properties of mitochondrial NADH-ubiquinone reductase (Complex I)	2	0
12183	1	11530 1999 BIOCHEMISTRY-MOSCOW 64(5):528-542 Reutov VP Biochemical predetermination of the NO synthase and nitrite reductase components of the nitric oxide cycle	3	0
12184	48	11531 1999 BIOCHEMISTRY-MOSCOW 64(7):725-737 Ivanov IV; Groza NV; Myagkova GI Cytochrome p450-dependent metabolism of arachidonic acid	2	0
12185	4	11538 1999 BIOFIZIKA 44(4):624-627 Matushkin YG; Morozova IN; Morozov PS Some features of evolution of cytochromes P450	0	0
12186	2	11539 1999 BIOLOGICAL RHYTHM RESEARCH 30(4):361-370 Male T; Feder J; Giaever GN; Giaever I Oscillations in yeast observed electrically	0	0
12187	6	11543 1999 BIOORGANIC CHEMISTRY 27(2):81-90 Flitsch SL; Aitken SJ; Chow CSY; Grogan G; Staines A Biohydroxylation reactions catalyzed by enzymes and whole-cell systems	8	0
12188	1	11546 1999 BRAIN RESEARCH 836(1-2):62-69 Centeno JM; Orti MA; Salom JB; Sick TJ; Perez-Pinzon MA Nitric oxide is involved in anoxic preconditioning neuroprotection in rat hippocampal slices	24	0
12189	13	11547 1999 BRAIN RESEARCH 842(1):139-147 Renton KW; Dibb S; Levatte TL Lipopolysaccharide evokes the modulation of brain cytochrome P4501A in the rat	7	0
12190	4	11548 1999 BRITISH JOURNAL OF ANAESTHESIA 82(2):255-265 Ciccone GK; Holdcroft A Drugs and sex differences: a review of drugs relating to anaesthesia	9	0
12191	3	11554 1999 CANADIAN JOURNAL OF CHEMICAL ENGINEERING 77(5):893-902 Sheppard JD; Dawson PSS Cell synchrony and periodic behaviour in yeast populations	1	0
12192	3	11555 1999 CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES 56(4):642-649 Foster EP; Curtis LR 2,2 ',4,4 ',5,5 '- and 3,3 ',4,4 ' 5,5 '- Hexachlorobiphenyl pretreatments alter the biliary excretion of a challenge dose of 7,12-[H-3]dimethylbenz[a]anthracene in rainbow trout (Oncorhyncus mykiss)	0	0
12193	5	11556 1999 CANADIAN JOURNAL OF MICROBIOLOGY 45(10):833-839 Kawahara N; Ikatsu H; Kawata H; Miyoshi S; Tomochika K; Sinoda S Purification and characterization of 2-ethoxyphenol-induced cytochrome P450 from Corynebacterium sp strain EP1	1	0
12194	14	11557 1999 CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 77(8):589-597 Di Re J; Lee C; Riddick DS Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin	2	0
12195	1	11559 1999 CANCER CAUSES & CONTROL 10(1):1-11 Dorgan JF; Brock JW; Rothman N; Needham LL; Miller R; Stephenson HE; Schussler N; Taylor PR Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA)	44	0
12196	7	11560 1999 CANCER CHEMOTHERAPY AND PHARMACOLOGY 43(1):59-67 Philip PA; Ali-Sadat S; Doehmer J; Kocarek T; Akhtar A; Lu H; Chan KK Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs	9	0
12197	5	11561 1999 CANCER LETTERS 138(1-2):73-79 Tateishi T; Nakura H; Asoh M; Watanabe M; Tanaka M; Kumai T; Kobayashi S Multiple cytochrome P-450 subfamilies are co-induced with P- glycoprotein by both phenothiazine and 2-acetylaminofluorene in rats	9	0
12198	8	11562 1999 CANCER LETTERS 138(1-2):131-137 Jeong HG; Lee SS Suppressive effects of alpha-Hederin on 2,3,7,8- tetrachlorodibenzo-p-dioxin-mediated murine Cypla-1 expression in the mouse hepatoma Hepa-1c1c7 cells	2	0
12199	15	11566 1999 CELLULAR AND MOLECULAR NEUROBIOLOGY 19(3):301-308 Baker GB Special issue: Drug metabolism and psychiatry: Part I of II - Preface	0	0
12200	16	11569 1999 CELLULAR AND MOLECULAR NEUROBIOLOGY 19(4):491-510 Fang J; Gorrod JW Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs	13	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12201	13	11570 1999 CELLULAR AND MOLECULAR NEUROBIOLOGY 19(4):533-552 Chouinard G; Lefko-Singh K; Teboul E Metabolism of anxiolytics and hypnotics: Benzodiazepines, buspirone, zoplicone, and zolpidem	2	0
12202	5	11571 1999 CELLULAR RESPONSES TO STRESS (64):129-139 Wolf CR; Smith G; Smith AG; Brown K; Henderson CJ Adaptive responses to environmental chemicals	0	0
12203	10	11575 1999 CHEMICO-BIOLOGICAL INTERACTIONS 117(3):257-268 Tateishi T; Asoh M; Nakura H; Watanabe M; Tanaka M; Kumai T; Kobayashi S Carbamazepine induces multiple cytochrome P450 subfamilies in rats	7	0
12204	8	11576 1999 CHEMICO-BIOLOGICAL INTERACTIONS 123(1):63-79 Nicolas JM; Whomsley R; Collart P; Roba J In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines	5	0
12205	7	11579 1999 CHEMOSPHERE 38(4):853-863 Vitas M; Smith KE; Plavec J; Kesselmeier J; Pajic T; Ferlan A; Zigon D; Kelly SL; Komel R Induction of steroidal hydroxylase activity by plant defence compounds in the filamentous fungus Cochliobolus lunatus	4	0
12206	4	11582 1999 CLINICAL NUTRITION 18(2):93-101 Fontana L; Moreira E; Torres MI; Periago JL; De Medina FS; Gil A Effects of dietary polyunsaturated fatty acids and nucleotides on tissue fatty acid profiles of rats with carbon tetrachloride-induced liver damage	2	0
12207	52	11583 1999 CLINICAL PHARMACOKINETICS 37(6):485-505 de Wildt SN; Kearns GL; Leeder JS; van den Anker JN Cytochrome P450 3A - Ontogeny and drug disposition	56	0
12208	2	11586 1999 CLINICAL TRANSPLANTATION 13(1):62-64 Tiao GM; Martin J; Weber FL; Cohen RM; Hanto DW Addisonian crisis in a liver transplant patient due to fluconazole withdrawal	1	0
12209	8	11590 1999 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 124(3):301-307 Wanwimolruk S; Zhang H; Coville PF; Saville DJ; Davis LS In vitro hepatic metabolism of a CYP3A-mediated drug, quinine, in Adelie penguins	1	0
12210	6	11594 1999 CURRENT OPINION IN CHEMICAL BIOLOGY 3(1):22-27 Holland HL C-H activation	8	0
12211	1	11596 1999 CYTOGENETICS AND CELL GENETICS 86(2):162-164 Wain H; White J; Povey S The changing challenges of nomenclature	1	0
12212	1	11597 1999 DIABETES 48(9):1890-1895 Chung WK; Luke A; Cooper RS; Rotini C; Vidal-Puig A; Rosenbaum M; Chua M; Solanes G; Zheng M; Zhao L; LeDuc C; Eisberg A; Chu F; Murphy E; Schreier M; Aronne L; Caprio S; Kahle B; Gordon D; Leal SM; Goldsmith R; Andreu AL; Bruno C; DiMauro S; Heo MS; Lowe WL; Lowell BB; Allison DB; Leibel RL Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis	26	0
12213	5	11600 1999 DRUG DEVELOPMENT RESEARCH 46(2):112-125 Dimmock JR; Puthucode RN; Tuchek J; Baker GB; Hinko CN; Steinmiller CL; Stables JP Anticonvulsant activities of 4-(4 '-fluorophenoxy) benzaldehyde semicarbazone	1	0
12214	13	11621 1999 DRUG METABOLISM REVIEWS 31(1):195-203 Jenkins CM; Waterman MR Flavodoxin as a model for the P450-interacting domain of NADPH cytochrome P450 reductase	0	0
12215	0	11623 1999 DRUG METABOLISM REVIEWS 31(2):297-302 Estabrook RW A tribute to Alfred Goerge Hildebrandt	0	0
12216	22	11624 1999 DRUG METABOLISM REVIEWS 31(2):317-331 Estabrook RW Discovering the functions of cytochrome P450 in drug metabolism: The role of Alfred Hildebrandt	0	0
12217	11	11625 1999 DRUG METABOLISM REVIEWS 31(2):333-342 Kagawa N; Bischof LJ; Cheng PY; Anwar A; Waterman MR Biochemical diversity of peptide-hormone-dependent regulation of steroidogenic P450s	3	0
12218	8	11631 1999 DRUGS 58(2):233-255 Njar VCO; Brodie AMH Comprehensive pharmacology and clinical efficacy of aromatase inhibitors	18	0
12219	5	11632 1999 DRUGS & AGING 14(2):75-90 Patterson A; Harris AL Molecular chemotherapy for breast cancer	13	0
12220	7	11633 1999 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 43(1):74-82 van Dam RA; Ahokas JT; Holdway DA Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis): Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity	1	0
12221	1	11636 1999 ENDOCRINOLOGY 140(10):4732-4738 Teixeira J; Fynn-Thompson E; Payne AH; Donahoe PK Mullerian-inhibiting substance regulates androgen synthesis at the transcriptional level	28	0
12222	12	11638 1999 ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 28(2):265-+ Rosenfield RL Ovarian and adrenal function in polycystic ovary syndrome	17	0
12223	6	11640 1999 ENVIRONMENTAL SCIENCE & TECHNOLOGY 33(10):1671-1674 Uchimura M; Sandeaux R; Larroque C The enzymatic detoxifying system of a native Mediterranean Scorpio fish is affected by Caulerpa taxifolia in its environment	2	0
12224	10	11641 1999 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 18(11):2565-2573 Levine SL; Oris JT; Denison MS Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propiconazole	3	0
12225	4	11642 1999 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 7(2):95-107 Pinelli E; El Adlouni C; Pipy B; Quartulli F; Pfohl-Leszkowicz A Roles of cyclooxygenase and lipoxygenases in ochratoxin A genotoxicity in human epithelial lung cells	6	0
12226	1	11643 1999 ENZYMOLOGY AND MOLECULAR BIOLOGY OF CARBONYL METABOLISM 7 463():255-263 Ziegler TL; Vasiliou V Aldehyde dehydrogenase gene superfamily - The 1998 update	5	0
12227	3	11644 1999 ESSAYS IN BIOCHEMISTRY, VOL 34, 1999 34():71-83 Sligar SG Nature's universal oxygenases: the cytochromes P450	6	0
12228	5	11645 1999 EUROPEAN HEART JOURNAL SUPPLEMENTS 1(T):T7-T12 Horsmans Y Differential metabolism of statins: importance in drug-drug interactions	5	0
12229	5	11646 1999 EUROPEAN HEART JOURNAL SUPPLEMENTS 1(T):T13-T18 Weissberg PL Atherosclerosis involves more than just lipids: plaque dynamics	6	0
12230	7	11650 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 260(3):768-773 Kisselev P; Tuckey RC; Woods ST; Triantopoulos T; Schwarz D Enzymatic properties of vesicle-reconstituted human cytochrome P450SCC (CYP11A1) - Differences in functioning of the mitochondrial electron-transfer chain using human and bovine adrenodoxin and activation by cardiolipin	2	0
12231	21	11652 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 262(2):435-446 Cabello-Hurtado F; Taton M; Forthoffer N; Kahn R; Bak S; Rahier A; Werck-Reichhart D Optimized expression and catalytic properties of a wheat obtusifoliol 14 alpha-demethylase (CYP51) expressed in yeast - Complementation of erg11 Delta yeast mutants by plant CYP51	8	0
12232	3	11656 1999 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 24(1):63-68 Klinger W; Oelschlager H; Rothley D; Karge E; Seeling A Interaction of chlormezanone enantiomers with rat liver microsomes	1	0
12233	7	11659 1999 EUROPEAN JOURNAL OF ENDOCRINOLOGY 141(1):35-39 Gallo M; Aragno M; Gatto V; Tamagno E; Brignardello E; Manti R; Danni O; Boccuzzi G Protective effect of dehydroepiandrosterone against lipid peroxidation in a human liver cell line	4	0
12234	8	11662 1999 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 51(4-5):392-396 Meneguz A; Fortuna S; Lorenzini P; Volpe MT Influence of urethane and ketamine on rat hepatic cytochrome P450 in vivo	2	0
12235	5	11664 1999 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 51(4-5):455-457 Zviarynski IU; Zavodnik LB The effect of folic acid on the drug metabolizing liver function in man with viral hepatitis	1	0
12236	4	11665 1999 EXPERIMENTAL CELL RESEARCH 250(2):284-297 Sonneveld E; van den Brink CE; van der Leede BJM; Maden M; van der Saag PT Embryonal carcinoma cell lines stably transfected with mRAR beta 2-lacZ: Sensitive system for measuring levels of active retinoids	7	0
12237	0	11666 1999 FASEB JOURNAL 13(7):A1345-A1345 Guryev OL; Gilep A; Usanov SA; Estabrook RW Cytochrome P4503A4-cytochrome bs interactions: Biological relevance of heme transfer	0	0
12238	1	11667 1999 FEBS LETTERS 456(1):85-88 Jornvall H Motifer, a search tool for finding amino acid sequence patterns from nucleotide sequence databases	0	0
12239	6	11671 1999 FERTILITY AND STERILITY 71(2):328-333 Nagamani M; Urban R Increased expression of messenger ribonucleic acid encoding cytochrome P450 cholesterol side-chain cleavage and P450 17 alpha-hydroxylase enzymes in ovarian hyperthecosis	4	0
12240	4	11672 1999 FERTILITY AND STERILITY 71(3):528-535 Jose M; Puche C; Cabero A; Cabero L; Meseguer A Expression of P450c17 messenger ribonucleic acid in postmenopausal human ovary tissues	5	0
12241	35	11673 1999 FOOD AND CHEMICAL TOXICOLOGY 37(4):423-453 Lake BG Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment	17	0
12242	6	11674 1999 FOOD AND CHEMICAL TOXICOLOGY 37(5):503-508 Ng HP; Wang YF; Lee CY; Hu ML Toxicological and antioxidant effects of short-term dehydroepiandrosterone injection in young rats fed diets deficient or adequate in vitamin E	2	0
12243	13	11677 1999 GASTROENTEROLOGY CLINICS OF NORTH AMERICA 28(1):1-+ Vlahcevic ZR; Pandak WM; Stravitz RT Regulation of bile acid biosynthesis	41	0
12244	9	11679 1999 GENERAL PHARMACOLOGY 33(4):325-336 Yang ZW; Zhang AM; Altura BT; Altura BM Hydrogen peroxide-induced endothelium-dependent relaxation of rat aorta - Involvement of Ca2+ and other cellular metabolites	14	0
12245	1	11680 1999 GENETIC EPIDEMIOLOGY 17(4):253-273 Yang P; Schwartz AG; McAllister AE; Swanson GM; Aston CE Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis	7	0
12246	1	11682 1999 HEPATO-GASTROENTEROLOGY 46():1406-1408 Suematsu M Recent developments in hepatic circulatory physiology	1	0
12247	15	11684 1999 HORMONE RESEARCH 51(5):211-222 Peter M; Dubuis JM; Sippell WG Disorders of the aldosterone synthase and steroid 11 beta- hydroxylase deficiencies	6	0
12248	9	11685 1999 INDUSTRIAL HEALTH 37(4):440-448 Wang RS; Nakajima T; Honma T Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat	1	0
12249	10	11686 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(2):145-151 Ranasinghe C; Hobbs AA Isolation and characterisation of a cytochrome b5 cDNA clone from Helicoverpa armigera (Hubner): possible involvement of cytochrome b5 in cytochrome P450 CYP6B7 activity towards pyrethroids	1	0
12250	10	11690 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(9):829-834 Crampton AL; Baxter CD; Barker SC A new family of cytochrome P450 genes (CYP41) from the cattle tick, Boophilus microplus	0	0
12251	6	11692 1999 INTERNATIONAL BIODETERIORATION & BIODEGRADATION 44(1):49-54 Gordeziani M; Khatisashvili G; Ananiashvili T; Varazashvili T; Kurashvili M; Kvesitadze G; Tkhelidze P Energetic significance of plant monooxygenase individual components participating in xenobiotics degradation	3	0
12252	8	11693 1999 INTERNATIONAL JOURNAL OF ANDROLOGY 22(4):211-223 Carreau S; Genissel C; Bilinska B; Levallet J Sources of oestrogen in the testis and reproductive tract in the male	41	0
12253	6	11694 1999 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 31(2):345-362 Arinc E; Cakir D Simultaneous purification and characterization of cytochrome b5 reductase and cytochrome b5 from sheep liver	1	0
12254	1	11695 1999 INTERNATIONAL JOURNAL OF CANCER 83(5):679-684 Bhisey RA; Ramchandani AG; D'Souza AV; Borges AM; Notani PN Long-term carcinogenicity of pan masala in Swiss mice	3	0
12255	2	11696 1999 INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY 21(7):455-462 Rezzani R; Rodella L; Bianchi R Early metabolic changes in peripheral blood cells of renal transplant recipients treated with Cyclosporine A	1	0
12256	5	11699 1999 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 75(9):1189-1199 Yukawa O; Nakajima T; Yukawa M; Ozawa T; Yamada T Induction of radical scavenging ability and protection against radiation-induced damage to microsomal membranes following low- dose irradiation	7	0
12257	9	11700 1999 JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS 38(1A):298-301 Suzuki-Tomii K; Ohta Y; Kawato S; Mitaku S Comparative experiments of protein denaturation for studying structural difference of homologous membrane proteins: P- 450(scc) and P-450(11 beta)	0	0
12258	11	11701 1999 JCR-JOURNAL OF CLINICAL RHEUMATOLOGY 5(3):143-150 Feldweg AM; Leddy JP Drug interactions affecting the efficacy of corticosteroid therapy - A brief review with an illustrative case	0	0
12259	9	11702 1999 JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE 15(4-5):96-98 Agradi E; Brevini TAL; Bolla M; Baga R; Favetta LA Cytochrome P-450 levels and EROD activity in the Adriatic sturgeon (Acipenser naccarii, Chondrostei) and its induction by beta-Naphthoflavone	1	0
12260	13	11704 1999 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 13(2):77-82 Carr BA; Franklin MR Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness	3	0
12261	7	11705 1999 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 13(6):307-315 Hu K; Bunce NJ Metabolism of polychlorinated dibenzo-p-dioxins by rat liver microsomes	8	0
12262	7	11706 1999 JOURNAL OF BIOCHEMISTRY 125(6):1094-1103 Kobayashi M; Sakuradani E; Shimizu S Genetic analysis of cytochrome b(5) from arachidonic acid- producing fungus, Mortierella alpina 1S-4: Cloning, RNA editing and expression of the gene in Escherichia coli, and purification and characterization of the gene product	8	0
12263	7	11709 1999 JOURNAL OF BIOCHEMISTRY 126(5):927-933 Nitahara Y; Aoyama Y; Horiuchi T; Noshiro M; Yoshida Y Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli	6	0
12264	11	11710 1999 JOURNAL OF BIOCHEMISTRY 126(6):1080-1089 Zimmer T; Ogura A; Ohta A; Takagi M Misfolded membrane-bound cytochrome P450 activates KAR2 induction through two distinct mechanisms	2	0
12265	25	11711 1999 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):226-231 Moon JY; Bin Lim H; Sohn HO; Lee YG; Lee DW Acetone enhancement of cumene hydroperoxide-supported microsomal cytochrome P450-dependent benzo(a)pyrene hydroxylation	1	0
12266	7	11712 1999 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 32(3):232-238 Kim KW; Kim HY; Park SS; Jeong HS; Park SH; Lee JY; Jeong JH; Moon YH Gender differences in activity and induction of hepatic microsomal cytochrome P-450 by 1-bromopropane in Sprague-Dawley rats	1	0
12267	2	11715 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(8):4985-4994 Houston M; Estevez A; Chumley P; Aslan M; Marklund S; Parks DA; Freeman BA Binding of xanthine oxidase to vascular endothelium - Kinetic characterization and oxidative impairment of nitric oxide- dependent signaling	43	0
12268	7	11720 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(45):32279-32286 Yamada K; Ogawa H; Honda S; Harada N; Okazaki T A GCM motif protein is involved in placenta-specific expression of human aromatase gene	16	0
12269	4	11722 1999 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 33(1):12-18 Reilly MP; Moran N; Meagher E; Delanty N; Cucchiara AE; Lawson JA; Catella-Lawson F A randomized, placebo-controlled, crossover study of E5510 and aspirin in healthy volunteers	1	0
12270	7	11723 1999 JOURNAL OF CELL SCIENCE 112(4):515-523 McLaughlin L; Burchell B; Pritchard M; Wolf CR; Friedberg T Treatment of mammalian cells with the endoplasmic reticulum- proliferator compactin strongly induces recombinant and endogenous xenobiotic metabolizing enzymes and 3-hydroxy-3- methylglutaryl-CoA reductase in vitro	2	0
12271	4	11724 1999 JOURNAL OF CHEMICAL ECOLOGY 25(3):537-548 Rey D; Cuany A; Pautou MP; Meyran JC Differential sensitivity of mosquito taxa to vegetable tannins	16	0
12272	1	11725 1999 JOURNAL OF CHEMICAL RESEARCH-S (1):32-33 Lerestif JM; Feuillet S; Bazureau JP; Hamelin J Novel synthesis of protected methyl 4-hydroxy-1,2,3,4- tetrahydroisoquinoline-3-carboxylate via cleavage of functionalized dihydrooxazoles (oxazolines)	3	0
12273	7	11728 1999 JOURNAL OF CHROMATOGRAPHY B 734(1):23-29 Soucek P Novel sensitive high-performance liquid chromatographic method for assay of coumarin 7-hydroxylation	2	0
12274	2	11730 1999 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(1):220-227 Feneberg R; Sparber M; Veldhuis JD; Mehls O; Ritz E; Schaefer F Synchronous fluctuations of blood insulin and lactate concentrations in humans	1	0
12275	40	11736 1999 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 19(5):23S-35S Greenblatt DJ; Von Moltke LL; Harmatz JS; Shader RI Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions	13	0
12276	11	11740 1999 JOURNAL OF HEPATOLOGY 31(2):263-270 Tanaka M; Nakura H; Tateishi T; Watanabe M; Nakaya S; Kumai T; Kobayashi S Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury	4	0
12277	3	11741 1999 JOURNAL OF HEPATOLOGY 31(3):550-555 Krahenbuhl S; Kleinle S; Henz S; Leibundgut K; Liechti S; Zimmermann A; Wiesmann U Microvesicular steatosis, hemosiderosis and rapid development of liver cirrhosis in a patient with Pearson's syndrome	7	0
12278	16	11745 1999 JOURNAL OF MEDICINAL CHEMISTRY 42(9):1515-1524 de Groot MJ; Ackland MJ; Horne VA; Alex AA; Jones BC Novel approach to predicting P450-mediated drug metabolism: Development of a combined protein and pharmacophore model for CYP2D6	54	0
12279	16	11746 1999 JOURNAL OF MEDICINAL CHEMISTRY 42(20):4062-4070 de Groot MJ; Ackland MJ; Horne VA; Alex AA; Jones BC A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6	42	0
12280	2	11749 1999 JOURNAL OF NEUROSCIENCE 19(24):10843-10855 de la Houssaye BA; Mikule K; Nikolic D; Pfenninger KH Thrombin-induced growth cone collapse: Involvement of phospholipase A(2) and eicosanoid generation	6	0
12281	19	11751 1999 JOURNAL OF PESTICIDE SCIENCE 24(2):197-203 Ohkawa H; Tsujii H; Shimoji M; Imajuku Y; Imaishi H Cytochrome P450 biodiversity and plant protection	5	0
12282	6	11761 1999 JOURNAL OF PHARMACY AND PHARMACOLOGY 51(10):1167-1174 Zhao XJ; Ishizaki T An in-vitro study on the metabolism of rokitamycin and possible interactions of the drug with rat liver microsomes	0	0
12283	2	11762 1999 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 69(1-6):205-210 Brodie A; Lu Q; Long B Aromatase and its inhibitors	14	0
12284	10	11763 1999 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 41(2):237-249 Gupta AK; Katz HI; Shear NH Drug interactions with itraconazole, fluconazole, and terbinafine and their management	32	0
12285	2	11765 1999 JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2):297-300 Rosen GM; Pou S; Cohen MS; Hassett DJ; Britigan BE; Barber MJ; Cao GL; Cosby K; Sturgeon BE; Halpern HJ N-14-spin trapping of free radicals in the presence of N-15- spin labeled Neisseria gonorrhoeae	0	0
12286	3	11767 1999 JOURNAL OF THE NATIONAL CANCER INSTITUTE 91(3):215-225 Hursting SD; Slaga TJ; Fischer SM; DiGiovanni J; Phang JM Mechanism-based cancer prevention approaches: Targets, examples, and the use of transgenic mice	36	0
12287	23	11769 1999 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS 2(2):183-210 Hu KK; Bunce NJ Metabolism of polychlorinated dibenzo-p-dioxins and related dioxin-like compounds	14	0
12288	4	11770 1999 JOURNAL OF VOICE 13(3):424-446 Abitbol J; Abitbol P; Abitbol B Sex hormones and the female voice	10	0
12289	6	11773 1999 LIFE SCIENCES 64(10):827-835 Mesdjian E; Seree E; Charvet B; Mirrione A; Bourgarel-Rey V; Desobry A; Barra Y Metabolism of carbamazepine by CYP3A6: A model for in vitro drug interactions studies	3	0
12290	6	11774 1999 LIFE SCIENCES 65(12):1257-1264 Jiang HB; Ichikawa Y Neuronal nitric oxide synthase catalyzes the reduction of 7- ethoxyresorufin	4	0
12291	5	11775 1999 LIFE SCIENCES 65(17):1747-1756 Kitamura T; Tanaka K; Morita K; Saito S; Kiba T; Numata K; Sekihara H Dehydroepiandrosterone (DHEA) facilitates liver regeneration after partial hepatectomy in rats	2	0
12292	3	11781 1999 MARINE ECOLOGY-PROGRESS SERIES 178():205-219 Muller WEG; Wiens M; Batel R; Steffen R; Schroder HC; Borojevic R; Custodio MR Establishment of a primary cell culture from a sponge: primmorphs from Suberites domuncula	36	0
12293	2	11782 1999 MEDICAL SCIENCE RESEARCH 27(9):617-620 Kalapos MP Influence of acetone on the hepatotoxicity of methylglyoxal	1	0
12294	16	11784 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 198(1-2):79-88 Ramana KV; Kohli KK Purification and characterization of the hepatic CYP2C and 3A isozymes from phenobarbitone pretreated rhesus monkey	1	0
12295	11	11785 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 198(1-2):89-100 Ikegwuonu FI; Jefcoate CR Evidence for the involvement of the fatty acid and peroxisomal beta-oxidation pathways in the inhibition by dehydroepiandrosterone (DHEA) and induction by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and benz(a) anthracene (BA) of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblasts (C3H10T1/2 cells)	5	0
12296	9	11786 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 200(1-2):169-176 Dhawan A; Parmar D; Dayal M; Seth PK Cytochrome P450 (P450) isoenzyme specific dealkylation of alkoxyresorufins in rat brain microsomes	7	0
12297	11	11788 1999 MOLECULAR BIOLOGY 33(4):618-621 Matushkin YG; Morozova IN; Morozov PS Theoretical analysis of mutation spectra of cytochrome P450	0	0
12298	11	11789 1999 MOLECULAR DIAGNOSIS 4(4):365-379 Linder MW; Valdes R Pharmacogenetics in the practice of laboratory medicine	9	0
12299	7	11796 1999 MOLECULAR PLANT-MICROBE INTERACTIONS 12(12):1044-1052 Oh BJ; Ko MK; Kim YS; Kim KS; Kostenyuk I; Kee HK A cytochrome P450 gene is differentially expressed in compatible and incompatible interactions between pepper (Capsicum annuum) and the anthracnose fungus, Colletotrichum gloeosporioides	3	0
12300	4	11804 1999 MYCOLOGICAL RESEARCH 103():1009-1018 Gramss G; Kirsche B; Voigt KD; Gunther T; Fritsche W Conversion rates of five polycyclic aromatic hydrocarbons in liquid cultures of fifty-eight fungi and the concomitant production of oxidative enzymes	11	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12301	11	11806 1999 NEOPLASMA 46(6):363-367 Iscan M; Eke BC; Aygormez S; Coban T; Bulbul D 7-Ethoxyresorufin O-deethylase (EROD) activity is not capable of reflecting the overall malignant potential of breast cancer tissue	0	0
12302	2	11807 1999 NEUROMUSCULAR DISORDERS 9(4):208-214 Weller B; Carpenter S; Lochmuller H; Karpati G Myopathy with trabecular muscle fibers	3	0
12303	14	11809 1999 ONCOLOGY RESEARCH 11(11-12):523-528 Knupfer H; Knupfer MM; Hotfilder M; Preiss R P450-expression in brain tumors	2	0
12304	5	11813 1999 PESTICIDE SCIENCE 55(11):1043-1058 Davies J; Caseley JC Herbicide safeners: a review	11	0
12305	3	11815 1999 PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY 2(3):119-120 Crespi CL Assessing the potential for drug-drug interactions in an accelerated throughput mode	6	0
12306	30	11816 1999 PHARMACOGENETICS 9(1):61-70 Louerat-Oriou B; Flinois JP; Beaune PH; Pompon D High yield purification and characterization of engineered human P450 1A2 and generation of immuno-inhibitor antibodies	0	0
12307	7	11817 1999 PHARMACOGENETICS 9(2):131-144 Tantcheva-Poor I; Zaigler M; Rietbrock S; Fuhr U Estimation of cytochrome P-450CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test	28	0
12308	9	11818 1999 PHARMACOGENETICS 9(2):239-250 Lovell DP; van Iersel M; Walters DG; Price RJ; Lake BG Genetic variation in the metabolism of coumarin in mouse liver	3	0
12309	19	11821 1999 PHARMACOGENETICS 9(3):357-366 Schulz-Utermoehl T; Bennett AJ; Ellis SW; Tucker GT; Boobis AR; Edwards RJ Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression	11	0
12310	14	11823 1999 PHARMACOLOGICAL REVIEWS 51(1):63-81 Mensah-Nyagan AG; Do-Rego JL; Beaujean D; Luu-The V; Pelletier G; Vaudry H Neurosteroids: Expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system	49	0
12311	5	11829 1999 PHYTOCHEMISTRY 52(7):1195-1202 Friederich S; Rueffer M; Asakawa Y; Zenk MH Cytochromes P-450 catalyze the formation of marchantins A and C in Marchantia polymorpha	7	0
12312	15	11831 1999 PLANT AND CELL PHYSIOLOGY 40(12):1232-1242 Takemoto D; Hayashi M; Doke N; Nishimura M; Kawakita K Molecular cloning of a defense-response-related cytochrome P450 gene from tobacco	2	0
12313	5	11833 1999 PLANT JOURNAL 19(4):441-451 Brugliera F; Barri-Rewell G; Holton TA; Mason JG Isolation and characterization of a flavonoid 3 '-hydroxylase cDNA clone corresponding to the Ht1 locus of Petunia hybrida	24	0
12314	4	11835 1999 PLANT MOLECULAR BIOLOGY REPORTER 17(4):355-361 Shimada Y; Ohbayashi M; Nakano-Shimada R; Okinaka Y; Kiyokawa S; Kikuchi Y A novel method to clone P450s with modified single-specific- primer PCR	1	0
12315	8	11837 1999 PLANT SCIENCE 149(2):105-113 Oudin A; Hamdi S; Ouelhazi L; Chenieux JC; Rideau M; Clastre M Induction of a novel cytochrome P450 (CYP96 family) in periwinkle (Catharanthus roseus) cells induced for terpenoid indole alkaloid production	4	0
12316	3	11843 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(22):12790-12797 New MI; Wilson RC Steroid disorders in children: Congenital adrenal hyperplasia and apparent mineralocorticoid excess	20	0
12317	6	11844 1999 PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 266(1414):1-12 von Schantz T; Bensch S; Grahn M; Hasselquist D; Wittzell H Good genes, oxidative stress and condition-dependent sexual signals	48	0
12318	18	11847 1999 PROTEINS-STRUCTURE FUNCTION AND GENETICS 37(2):204-217 Payne VA; Chang YT; Loew GH Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes	5	0
12319	2	11849 1999 RUSSIAN JOURNAL OF GENERAL CHEMISTRY 69(6):936-953 Shugalei IV; Tselinskii IV Nitroalkanes as initiators of radical chain processes in chemistry and biology	1	0
12320	2	11852 1999 SCIENCES DES ALIMENTS 19(5):515-542 Aurousseau B The origin of ovine carcass discoloration: a review.	1	0
12321	9	11854 1999 TOXICOLOGICAL SCIENCES 47(1):52-61 Korytko PJ; Casey AC; Bush B; Quimby FW Induction of hepatic cytochromes P450 in dogs exposed to a chronic low dose of polychlorinated biphenyls	4	0
12322	2	11856 1999 TOXICOLOGICAL SCIENCES 49(1):15-28 Collins AS; Sumner SCJ; Borghoff SJ; Medinsky MA A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures	7	0
12323	7	11857 1999 TOXICOLOGICAL SCIENCES 52(1):130-139 Inder RE; Bray BJ; Sipes IG; Rosengren RJ Role of cytochrome P4502E1 in retinol's attenuation of carbon tetrachloride-induced hepatotoxicity in the Swiss Webster mouse	3	0
12324	0	11860 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 154(2):126-134 Metosh-Dickey CA; Mason RP; Winston GW Nitroarene reduction and generation of free radicals by cell- free extracts of wild-type, and nitroreductase-deficient and - enriched Salmonella typhimurium strains used in the umu gene induction assay	1	0
12325	9	11863 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 157(3):157-165 Ertl RP; Bandiera SM; Buhler DR; Stegeman JJ; Winston GW Immunochemical analysis of liver microsomal cytochromes P450 of the American alligator, Alligator mississippiensis	1	0
12326	14	11868 1999 USPEKHI KHIMII 68(10):967-975 Shumyantseva VV; Bulko TV; Archakov AI Regulation of cytochrome P450S catalytic activities by means of physico-chemical methods	0	0
12327	7	11869 1999 VETERINARY AND HUMAN TOXICOLOGY 41(4):210-212 Govindwar SP; Adav SS Effects of aflatoxin B-1 on the hepatic microsomal mixed function oxidase system during phenobarbital and benzo(a)pyrene treatment in chickens	0	0
12328	6	11871 1999 VOPROSY MEDITSINSKOI KHIMII 45(1):30-36 Schwartz EI; Gulyaeva LF; Lyakhovich VV The interstrain differences in the enzymatic activity of CYP2B1 and expression of its gene in rat liver during induction with phenobarbital and triphenyldioxane	0	0
12329	4	11872 1999 WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 15(2):259-263 Salokhe MD; Govindwar SP Effect of carbon source on the biotransformation enzymes in Serratia marcescens	0	0
12330	9	11873 1999 WORLD JOURNAL OF SURGERY 23(1):6-11 Izuishi K; Wakabayashi H; Kokudo Y; Maeba T; Ryu M; Maeta H Microsomal cytochrome P-450 monooxygenase system and its drug- metabolizing activity after partial portal vein ligation in the rat	1	0
12331	14	11879 1999 XENOBIOTICA 29(6):629-640 Roos PH Common multiple interactions of tricyclic antidepressants and orphenadrine with liver microsomal cytochrome P450 enzymes of the rat	0	0
12332	2	11880 1999 XENOBIOTICA 29(7):655-691 Rockett JC; Esdaile DJ; Gibson GG Differential gene expression in drug metabolism and toxicology: practicalities, problems and potential	4	0
12333	7	11883 1999 XENOBIOTICA 29(8):815-826 Kashiyama E; Yokoi T; Odomi M; Kamataki T Stereoselective S-oxidation and reduction of flosequinan in rat	0	0
12334	11	11887 1999 XENOBIOTICA 29(12):1213-1226 Hanioka N; Jinno H; Tanaka-Kagawa T; Nishimura T; Ando M In vitro metabolism of simazine, atrazine and propazine by hepatic cytochrome P450 enzymes of rat, mouse and guinea pig, and oestrogenic activity of chlorotriazines and their main metabolites	4	0
12335	2	11888 1999 ZEITSCHRIFT FUR GASTROENTEROLOGIE 37(5):367-378 Strohmeyer G; Weik C Drug-induced liver disease	2	0
12336	16	11890 2000 ACTA BIOCHIMICA POLONICA 47(4):1093-1105 Czekaj P Phenobarbital-induced expression of cytochrome P450 genes	0	0
12337	6	11891 2000 ACTA PHARMACOLOGICA SINICA 21(8):673-679 Han XM; Zhou HH Polymorphism of CYP450 and cancer susceptibility	4	0
12338	8	11893 2000 ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 55 55():175-263 El Khadem HS; Fatiadi AJ Hydrazine derivatives of carbohydrates and related compounds	1	0
12339	3	11894 2000 AMERICAN JOURNAL OF CLINICAL NUTRITION 72(2):670S-674S Jenkins RR Exercise and oxidative stress methodology: a critique	4	0
12340	5	11896 2000 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 279(6):L1005-L1028 Thannickal VJ; Fanburg BL Reactive oxygen species in cell signaling	108	0
12341	8	11900 2000 ANAESTHESIA 55(6):540-544 Chimbira W; Sweeney BP The effect of smoking on postoperative nausea and vomiting	6	0
12342	11	11901 2000 ANDROLOGIA 32(4-5):255-262 Schuppe HC; Wieneke P; Donat S; Fritsche E; Kohn FM; Abel J Xenobiotic metabolism, genetic polymorphisms and male infertility	2	0
12343	2	11906 2000 AQUATIC TOXICOLOGY 50(4):403-415 van Schanke A; Boon JP; Aardoom Y; van Leest A; van Schooten FJ; Maas L; van den Berg M; Everaarts JM Effect of a dioxin-like PCB (CB 126) on the biotransformation and genotoxicity of benzo[a]pyrene in the marine flatfish dab (Limanda limanda)	8	0
12344	6	11912 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 375(1):145-153 Kneer N; Lardy H Thyroid hormone and dehydroepiandrosterone permit gluconeogenic hormone responses in hepatocytes	1	0
12345	13	11916 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 379(1):97-108 O'Leary KA; Kasper CB Molecular basis for cell-specific regulation of the NADPH- cytochrome P450 oxidoreductase gene	4	0
12346	19	11919 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 380(1):117-125 Parimoo B; Thomas PE Epitope mapping of rat cytochrome P4502B1 using glutathione S- transferase-2B1 fusion constructs	1	0
12347	10	11920 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 380(2):367-372 Bobyleva V; Pazienza L; Muscatello U; Kneer N; Lardy H Short-term hypothermia activates hepatic mitochondrial sn- glycerol-3-phosphate dehydrogenase and thermogenic systems	2	0
12348	19	11922 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 381(2):191-204 Blume N; Leonard J; Xu ZJ; Watanabe O; Remotti H; Fishman J Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells	1	0
12349	19	11923 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 383(1):70-78 Hudecek J; Anzenbacherova E; Anzenbacher P; Munro AW; Hildebrandt P Structural similarities and differences of the heme pockets of various P450 isoforms as revealed by resonance Raman spectroscopy	2	0
12350	9	11924 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 383(1):119-127 Hsu PY; Tsai AL; Wang LH Identification of thromboxane synthase amino acid residues involved in heme-propionate binding	2	0
12351	3	11930 2000 ARCHIVES OF TOXICOLOGY 74(7):379-387 Laube B; Winkler S; Ladstetter B; Scheller T; Schwarz LR Establishment of a novel in vitro system for studying the interaction of xenobiotic metabolism of liver and intestinal microflora	0	0
12352	3	11932 2000 ARCHIVES OF TOXICOLOGY 74(7):415-420 Bertini S; Del Carratore R; Giorgi M; Bronzetti G; Della Croce C Genotoxic and mono-oxygenase system effects of the fungicide maneb	0	0
12353	9	11934 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 267(2):572-576 Guigal N; Seree E; Bourgarel-Rey V; Barra Y Induction of CYP1A1 by serum independent of AhR pathway	7	0
12354	7	11937 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(2):393-396 Mushiroda T; Ariyoshi N; Kimura K; Takahara E; Nagata O; Kato H; Kamataki T A high-level expression of CYP2A in the lung of the suncus (Suncus murinus) and its role in the activation of 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone	0	0
12355	2	11940 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 271(3):788-795 Lee PL; Halloran C; Cross AR; Beutler E NADH-ferric reductase activity associated with dihydropteridine reductase	5	0
12356	23	11942 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 273(3):1132-1137 Maibeche-Coisne M; Monti-Dedieu L; Aragon S; Dauphin-Villemant C A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system	3	0
12357	8	11944 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 277(3):594-598 Jeong HG; Kim JY; Choi CY Down-regulation of murine Cyp1a-1 in mouse hepatoma Hepa-1c1c7 cells by bisphenol A	2	0
12358	7	11945 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279(1):288-292 Jarukamjorn K; Sakuma T; Nemoto N Discriminating activation of CYP2B9 expression in male C57BL/6 mouse liver by beta-estradiol	4	0
12359	9	11949 2000 BIOCHEMICAL PHARMACOLOGY 59(5):583-589 Oinonen T; Ronis M; Wigell T; Tohmo K; Badger T; Lindros KO Growth hormone-regulated periportal expression of CYP2C7 in rat liver	1	0
12360	10	11950 2000 BIOCHEMICAL PHARMACOLOGY 59(8):997-1005 Puga A; Barnes SJ; Chang CY; Zhu H; Nephew KP; Khan SA; Shertzer HG Activation of transcription factors activator protein-1 and nuclear factor-kappa B by 2,3,7,8-tetrachlorodibenzo-p-dioxin	23	0
12361	28	11951 2000 BIOCHEMICAL PHARMACOLOGY 59(10):1277-1287 Kawai M; Bandiera SM; Chang TKH; Bellward GD Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2	7	0
12362	10	11953 2000 BIOCHEMICAL PHARMACOLOGY 60(6):857-863 Ueno T; Tamura S; Frels WI; Shou M; Gonzalez FJ; Kimura S A transgenic mouse expressing human CYP1A2 in the pancreas	3	0
12363	6	11958 2000 BIOCHEMISTRY 39(20):5961-5970 Ihara M; Takahashi S; Ishimori K; Morishima I Functions of fluctuation in the heme-binding loops of cytochrome b(5) revealed in the process of heme incorporation	6	0
12364	9	11960 2000 BIOCHEMISTRY 39(24):7117-7130 Arnesano F; Banci L; Bertini I; Koulougliotis D; Monti A Monitoring mobility in the early steps of unfolding: The case of oxidized cytochrome b(5) in the presence of 2 M guanidinium chloride	7	0
12365	4	11961 2000 BIOCHEMISTRY 39(30):8859-8869 Reynolds CM; Poole LB Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity	12	0
12366	11	11964 2000 BIOCHEMISTRY 39(41):12699-12707 Murataliev MB; Feyereisen R Functional interactions in cytochrome P450(BM3). Evidence that NADP(H) binding controls redox potentials of the flavin cofactors	2	0
12367	2	11967 2000 BIOCHEMISTRY-MOSCOW 65(8):972-975 Sumbayev VV In vitro effects of corticosteroids, DDT, and 4,9- dichlorodibenzodioxin on rat liver xanthine oxidase activity. Interactions between xanthine oxidase and cytochrome P450 in rat liver in vivo	1	0
12368	5	11968 2000 BIOCHEMISTRY-MOSCOW 65(10):1206-1211 Kovaleva IE; Grivennikov SI; Luzikov VN On the effect of cholesterol on the fate of CYP11A1 imported into yeast mitochondria in vivo	0	0
12369	1	11971 2000 BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1465(1-2):79-103 Theodoulou FL Plant ABC transporters	32	0
12370	9	11972 2000 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1529(1-3):126-135 Russell DW Oxysterol biosynthetic enzymes	27	0
12371	7	11975 2000 BIOFIZIKA 45(6):1013-1018 Shumyantseva VV; Bulko TV; Schmid RD; Archakov AI Photoreduction of flavocytochrome P4502B4	1	0
12372	2	11977 2000 BIOMARKERS 5(2):81-107 Neghab M; Stacey NH Serum bile acids as a sensitive biological marker for evaluating hepatic effects of organic solvents	2	0
12373	2	11979 2000 BIOORGANICHESKAYA KHIMIYA 26(2):97-111 Preobrazhenskaya MN; Korolev AM Indole derivatives in vegetables of the Cruciferae family	1	0
12374	6	11980 2000 BIOTECHNOLOGY LETTERS 22(1):3-8 Engler KH; Kelly SL; Coker RD; Evans IH Toxin-binding properties of cytochrome P450 in Saccharomyces cerevisiae and Kluyveromyces marxianus	1	0
12375	6	11982 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 49():35S-42S Prakash C; Kamel A; Cui D; Whalen RD; Miceli JJ; Tweedie D Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions	26	0
12376	10	11983 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 49(2):145-151 Ou-Yang DS; Huang SL; Wang W; Xie HG; Xu ZH; Shu Y; Zhou HH Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population	15	0
12377	9	11986 2000 BRITISH JOURNAL OF PHARMACOLOGY 129(3):547-554 Fearon IM; Ball SG; Peers C Clotrimazole inhibits the recombinant human cardiac L-type Ca2+ channel alpha(1C) subunit	4	0
12378	3	11992 2000 CARCINOGENESIS 21(4):669-676 Alexandrie AK; Warholm M; Carstensen U; Axmon A; Hagmar L; Levin JO; Ostman C; Rannug A CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure	21	0
12379	3	11993 2000 CARCINOGENESIS 21(6):1163-1166 Schabath MB; Spitz MR; Zhang XM; Delclos GL; Wu XF Genetic variants of myeloperoxidase and lung cancer risk	28	0
12380	2	11996 2000 CELL BIOLOGY INTERNATIONAL 24(8):569-580 Gilbert D; Lloyd D The living cell: A complex autodynamic multi-oscillator system?	3	0
12381	2	11997 2000 CELLULAR AND MOLECULAR BIOLOGY 46(7):1191-1212 Krieg R; Halbhuber KJ; Oehring H Novel chromogenic substrates with metal chelating properties for the histochemical detection of peroxidasic activity, derived from 3-amino-9-ethylcarbazole (AEC) and 3,6-diamino-9- ethylcarbazole	0	0
12382	3	12000 2000 CHEMICO-BIOLOGICAL INTERACTIONS 126(1):45-61 Soucek P; Ivan G; Pavel S Effect of the microsomal system on interconversions between hydroquinone, benzoquinone, oxygen activation, and lipid peroxidation	3	0
12383	3	12004 2000 CIRCULATION RESEARCH 87(7):566-573 Shinozaki K; Nishio Y; Okamura T; Yoshida Y; Maegawa H; Kojima H; Masada M; Toda N; Kikkawa R; Kashiwagi A Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats	38	0
12384	7	12005 2000 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 27(10):796-800 Buzaleh AM; Martinez MD; Batlle AMD Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: Studies on the haem pathway	1	0
12385	4	12008 2000 CLINICAL CHEMISTRY 46(11):1834-1836 van Schaik RHN; de Wildt SN; van Iperen NM; Uitterlinden AG; van den Anker JN; Lindemans J CYP3A4-V polymorphism detection by PCR-restriction fragment length polymorphism analysis and its allelic frequency among 199 Dutch Caucasians	3	0
12386	25	12011 2000 CLINICAL PHARMACOKINETICS 39(2):127-153 Carrillo JA; Benitez J Clinically significant pharmacokinetic interactions between dietary caffeine and medications	8	0
12387	21	12013 2000 CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY 18(2):215-239 Boitier E; Beaune P Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders - An update	1	0
12388	3	12015 2000 CLINICS IN CHEST MEDICINE 21(1):47-+ Tanoue LT Cigarette smoking and women's respiratory health	2	0
12389	16	12016 2000 COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS 65(1):122-132 Borek-Dohalska L; Hodek P; Stiborova M New selective inhibitors of cytochrome P4502B4 and an activator of cytochrome P450 3A6 in rabbit liver microsomes	3	0
12390	19	12017 2000 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 125(2):203-214 Rotchell JM; Steventon GB; Bird DJ Catalytic properties of CYP1A isoforms in the liver of an agnathan (Lampetra fluviatilis) and two species of teleost (Pleuronectes flesus, Anguilla anguilla)	2	0
12391	19	12021 2000 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 127(2):143-152 Oka T; Fukuhara M; Ushio F; Kurose K Molecular cloning and characterization of three novel cytochrome P450 2D isoforms, CYP2D20, CYP2D27, and CYP2D28 in the Syrian hamster (Mesocricetus auratus)	1	0
12392	4	12022 2000 CRITICAL CARE MEDICINE 28(3):809-817 Shimizu H; Takahashi T; Suzuki T; Yamasaki A; Fujiwara T; Odaka Y; Hirakawa M; Fujita H; Akagi R Protective effect of heme oxygenase induction in ischemic acute renal failure	23	0
12393	25	12025 2000 CURRENT DRUG METABOLISM 1(1):67-84 Murray M Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation	3	0
12394	38	12026 2000 CURRENT DRUG METABOLISM 1(2):107-132 Sheweita SA Drug-metabolizing enzymes: Mechanisms and functions	12	0
12395	14	12027 2000 CURRENT DRUG METABOLISM 1(4):305-331 Lin JH Sense and nonsense in the prediction of drug-drug interactions	5	0
12396	54	12029 2000 CURRENT ORGANIC CHEMISTRY 4(3):263-282 Martinez CA; Stewart JD Cytochrome P450's: Potential catalysts for asymmetric olefin epoxidations	4	0
12397	14	12030 2000 CURRENT SCIENCE 79(12):1665-1671 Das S; Tyagi AK; Kaur H Cancer modulation by glucosinolates: A review	0	0
12398	5	12031 2000 DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT 125(3):63-67 Martin-Facklam M; Drewe J; Haefeli WE Drug interactions with the cytochrome P 450 system	8	0
12399	5	12032 2000 DIGESTIVE AND LIVER DISEASE 32(1):39-45 Clemente MG; De Virgiliis S Autoantigen characterization in liver/kidney microsome positive hepatitis	0	0
12400	2	12034 2000 DNA AND CELL BIOLOGY 19(6):319-329 Piletz JE; Ivanov TR; Sharp JD; Ernsberger P; Chang CH; Pickard RT; Gold G; Roth B; Zhu H; Jones JC; Baldwin J; Reis DJ Imidazoline receptor antisera-selected (IRAS) cDNA: Cloning and characterization	15	0

#	Cited nodes	Nodes / Authors	GCS	LCS
12401	3	12038 2000 DRUG METABOLISM AND DISPOSITION 28(2):131-138 Arora V; Iversen PL Antisense oligonucleotides targeted to the p53 gene modulate liver regeneration in vivo	11	0
12402	7	12041 2000 DRUG METABOLISM AND DISPOSITION 28(7):715-717 Schulz-Utermoehl T; Mountfield RJ; Madsen K; Jorgensen PN; Hansen KT Selective and potent inhibition of human CYP2C19 activity by a conformationally targeted antipeptide antibody	2	0
12403	24	12042 2000 DRUG METABOLISM AND DISPOSITION 28(7):718-725 Schulz-Utermoehl T; Mountfield RJ; Bywater RP; Madsen K; Jorgensen PN; Hansen KT Structure-function analysis of human CYP3A4 using a specific proinhibitory antipeptide antibody	1	0
12404	6	12043 2000 DRUG METABOLISM AND DISPOSITION 28(7):737-741 Sweeny DJ; Lynch G; Bidgood AM; Lew W; Wang KY; Cundy KC Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat	0	0
12405	2	12047 2000 DRUG METABOLISM AND DISPOSITION 28(10):1217-1221 Ng CY; Ghabrial H; Morgan DJ; Ching MS; Smallwood RA; Angus PW Impaired elimination of propranolol due to right heart failure: Drug clearance in the isolated liver and its relationship to intrinsic metabolic capacity	2	0
12406	49	12050 2000 DRUG METABOLISM REVIEWS 32(1):45-79 Kato R; Yamazoe Y History of drug metabolism research in Japan	0	0
12407	0	12052 2000 ENDOCRINE RESEARCH 26(4):693-694 Bernhardt R; Estabrook RW Steroidogenic enzymes - Session summary	0	0
12408	2	12055 2000 ENDOCRINOLOGY 141(4):1317-1324 Kinuta K; Tanaka H; Moriwake T; Aya K; Kato S; Seino Y Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads	18	0
12409	9	12056 2000 ENDOCRINOLOGY 141(11):4100-4106 Pampori NA; Shapiro BH Nominal growth hormone pulses in otherwise normal masculine plasma profiles induce intron retention of overexpressed hepatic CYP2C11 with associated nuclear splicing deficiency	4	0
12410	2	12057 2000 ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 29(4):789-+ White JR; Campbell RK Dangerous and common drug interactions in patients with diabetes mellitus	2	0
12411	2	12058 2000 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 35(2):139-149 Taras-Valero D; Perin-Roussel O; Plessis MJ; Zajdela F; Perin F Tissue-specific activities of methylated dibenzo[c,g]carbazoles in mice: Carcinogenicity, DNA adduct formation, and CYP1A induction in liver and skin	1	0
12412	9	12061 2000 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 19(11):2806-2811 Drenth HJ; Van Oevelen CJC; Buitenhuis CJK; Van den Berg M Induction of hepatic cytochrome P450 activities by toxaphene in rat and Japanese quail	1	0
12413	13	12062 2000 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 8(3):197-204 Spotti M; Maas RFM; de Nijs CM; Fink-Gremmels J Effect of fumonisin B-1 on rat hepatic P450 system	1	0
12414	8	12064 2000 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 9(1-2):31-37 Asteinza J; Camacho-Carranza R; Reyes-Reyes RE; Dorado-Gonzalez V; Espinosa-Aguirre JJ Induction of cytochrome P450 enzymes by albendazole treatment in the rat	3	0
12415	16	12066 2000 EUROPEAN JOURNAL OF BIOCHEMISTRY 267(4):963-970 Marc N; Galisteo M; Lagadic-Gossmann D; Fautrel A; Joannard F; Guillouzo A; Corcos L Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture - Involvement of calcium- and cAMP-dependent pathways	7	0
12416	3	12067 2000 EUROPEAN JOURNAL OF BIOCHEMISTRY 267(9):2705-2710 Baciocchi E; Gerini MF; Harvey PJ; Lanzalunga O; Mancinelli S Oxidation of aromatic sulfides by lignin peroxidase from Phanerochaete chrysosporium	9	0
12417	10	12071 2000 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 30():14-20 Peter M; Dubuis JM Transcription factors as regulators of steroidogenic P-450 enzymes	1	0
12418	26	12073 2000 EUROPEAN JOURNAL OF NUTRITION 39(6):270-276 Amet Y; Plee-Gautier E; Berthou F; Adas F; French SW Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes	1	0
12419	11	12074 2000 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 12(2):103-110 Schellens JHM; Malingre MM; Kruijtzer CMF; Bardelmeijer HA; van Tellingen O; Schinkel AH; Beijnen JH Modulation of oral bioavailability of anticancer drugs: from mouse to man	10	0
12420	7	12075 2000 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 49(2):129-135 Brunner LJ; Werner U; Gravenall CE Effect of dose on cyclosporine-induced suppression of hepatic cytochrome P450 3A2 and 2C11	2	0
12421	3	12077 2000 FARADAY DISCUSSIONS (116):15-22 Davis JJ; Djuricic D; Lo KKW; Wallace ENK; Wong LL; Hill HAO A scanning tunnelling study of immobilised cytochrome P450(cam)	13	0
12422	4	12078 2000 FARADAY DISCUSSIONS (116):135-153 Sadeghi SJ; Meharenna YT; Fantuzzi A; Valetti F; Gilardi G Engineering artificial redox chains by molecular 'Lego'	10	0
12423	7	12080 2000 FISH PHYSIOLOGY AND BIOCHEMISTRY 22(3):199-206 Perkins EJ; DeBusk BC; Schlenk D Isolation of a novel hepatic CYP2-related protein from channel catfish, Ictalurus punctatus	1	0
12424	5	12081 2000 FISHERIES SCIENCE 66(2):358-364 Iijima N; Chosa S; Hada T; Kayama M Identification of 12-lipoxygenase products in the gills of carp, Cyprinus carpio	3	0
12425	4	12082 2000 FITOTERAPIA 71(1):25-33 Janbaz KH; Gilani AH Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents	1	0
12426	1	12086 2000 GASTROENTEROLOGY 119(3):794-805 Titos E; Claria J; Bataller R; Bosch-Marce M; Gines P; Jimenez W; Arroyo V; Rivera F; Rodes J Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis	7	0
12427	17	12087 2000 GENE 256(1-2):83-91 Leaver MJ; George SG A cytochrome P4501B gene from a fish, Pleuronectes platessa	0	0
12428	10	12089 2000 GENERAL AND COMPARATIVE ENDOCRINOLOGY 118(1):123-133 Kazeto Y; Ijiri S; Todo T; Adachi S; Yamauchi K Molecular cloning and characterization of Japanese eel ovarian P450c17 (CYP17) cDNA	11	0
12429	10	12090 2000 GENETICA 110(3):257-265 Fogleman JC; Danielson PB Analysis of fragment homology among DNA sequences from cytochrome P450 families 4 and 6	0	0
12430	2	12091 2000 GENOME RESEARCH 10(12):1958-1967 Del Punta K; Rothman A; Rodriguez I; Mombaerts P Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse	13	0
12431	1	12094 2000 HAEMOPHILIA 6(5):487-490 Wilde JT Protease inhibitor therapy and bleeding	2	0
12432	9	12095 2000 HEPATOLOGY 32(1):49-55 Siewert E; Bort R; Kluge R; Heinrich PC; Castell J; Jover R Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent	17	0
12433	10	12096 2000 HUMAN & EXPERIMENTAL TOXICOLOGY 19(11):623-631 Gyamfi MA; Hokama N; Oppong-Boachie K; Aniya Y Inhibitory effects of the medicinal herb, Thonningia sanguinea, on liver drug metabolizing enzymes of rats	1	0
12434	14	12099 2000 INSECT MOLECULAR BIOLOGY 9(5):441-449 Korytko PJ; MacIntyre RJ; Scott JG Expression and activity of a house-fly cytochrome P450, CYP6D1, in Drosophila melanogaster	0	0
12435	3	12101 2000 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 38(1):30-34 Farker K; Lehmann MH; Kastner R; Weber J; Janitzky V; Schubert J; Hoffmann A Analysis of point mutation in exon 2 of CYP2E1 gene in renal cell/urothelial cancer patients in comparison with control population	5	0
12436	7	12102 2000 INTERNATIONAL JOURNAL OF ENVIRONMENT AND POLLUTION 13(1-6):56-91 Livingstone DR; Chipman JK; Lowe DM; Minier C; Mitchelmore CL; Moore MN; Peters LD; Pipe RK Development of biomarkers to detect the effects of organic pollution on aquatic invertebrates: recent molecular, genotoxic, cellular and immunological studies on the common mussel (Mytilus edulis L.) and other mytilids	12	0
12437	73	12103 2000 INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 198 198():109-152 Kanamura S; Watanabe J Cell biology of cytochrome P-450 in the liver	0	0
12438	1	12106 2000 JOURNAL OF ADVERTISING 29(4):41-58 Gould SJ; Gupta PB; Grabner-Krauter S Product placements in movies: A cross-cultural analysis of Austrian, French and American consumers' attitudes toward this emerging, international promotional medium	0	0
12439	2	12107 2000 JOURNAL OF ANIMAL SCIENCE 78(2):371-379 Engelbrecht Y; Herselman T; Louw A; Swart P Investigation of the primary cause of hypoadrenocorticism in South African Angora goats (Capra aegagrus): A comparison with Boer goats (Capra hircus) and Merino sheep (Ovis aries)	1	0
12440	4	12108 2000 JOURNAL OF APPLIED TOXICOLOGY 20(6):455-461 Poon R; Nadeau B; Chu I Biochemical effects of chloral hydrate on male rats following 7-day drinking water exposure	2	0
12441	3	12110 2000 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 14(6):335-345 Nicholls-Grzemski FA; Belling GB; Priestly BG; Calder IC; Burcham PC Clofibrate pretreatment in mice confers resistance against hepatic lipid peroxidation	1	0
12442	2	12111 2000 JOURNAL OF BIOCHEMISTRY 127(1):151-161 Furukawa H; Haga T Expression of functional M-2 muscarinic acetylcholine receptor in Escherichia coli	7	0
12443	8	12119 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(22):16543-16549 Li-Hawkins J; Lund EG; Bronson AD; Russell DW Expression cloning of an oxysterol 7 alpha-hydroxylase selective for 24-hydroxycholesterol	25	0
12444	6	12122 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(47):36637-36644 Reyland ME; Evans RM; White EK Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells	4	0
12445	8	12124 2000 JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 5(2):204-212 Tschirret-Guth RA; Koo LS; de Montellano PRO Protein control of the formation and decomposition of the CYP119 and CYP101 aryl-iron complexes	4	0
12446	13	12125 2000 JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 5(4):422-431 Banci L; Presenti C Perspectives in inorganic structural biology: solution structures of metalloproteins	8	0
12447	13	12126 2000 JOURNAL OF BIOMEDICAL SCIENCE 7(2):144-151 Yeh JR; Hsu LC; Chung BC Sp1-like proteins function in the transcription of human ferredoxin genes	1	0
12448	5	12129 2000 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 35(2):227-233 Satake N; Imanishi M; Keto Y; Yamada H; Ishikawa M; Shibata S Genistein potentiates the relaxation induced by beta(1)- and beta(2)-adrenoceptor activation in rat aortic rings	3	0
12449	14	12130 2000 JOURNAL OF CELLULAR BIOCHEMISTRY 76(4):686-694 LaBella FS; Queen GM; Brandes LJ Interactive binding at cytochrome P-450 of cell growth regulatory bioamines, steroid hormones, antihormones, and drugs	3	0
12450	1	12132 2000 JOURNAL OF CHROMATOGRAPHY B 737(1-2):119-130 Begum RR; Newbold RJ; Whitford D Purification of the membrane binding domain of cytochrome b(5) by immobilised nickel chelate chromatography	4	0
12451	3	12133 2000 JOURNAL OF CHROMATOGRAPHY B 741(2):145-153 Madani S; Howald WN; Lawrence RF; Shen DD Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography- mass spectrometry	1	0
12452	3	12135 2000 JOURNAL OF CHROMATOGRAPHY B 746(2):331-338 Bendriss EK; Markoglou N; Wainer IW Liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine	6	0
12453	1	12137 2000 JOURNAL OF CLINICAL MICROBIOLOGY 38(4):1609-1614 Posteraro B; Sanguinetti M; Masucci L; Romano L; Morace G; Fadda G Reverse cross blot hybridization assay for rapid detection of PCR-amplified DNA from Candida species, Cryptococcus neoformans, and Saccharomyces cerevisiae in clinical samples	6	0
12454	12	12138 2000 JOURNAL OF CLINICAL ONCOLOGY 18(11):2301-2308 Yamamoto N; Tamura T; Kamiya Y; Sekine I; Kunitoh H; Saijo N Correlation between docetaxel clearance and estimated cytochrome P450 activity by urinary metabolite of exogenous cortisol	7	0
12455	4	12139 2000 JOURNAL OF FOOD AND DRUG ANALYSIS 8(3):166-173 Chang HC; Seng JE; Leakey JEA; Gandy J Metabolism of flutamide in diet control Fischer 344 and Brown Norway x F 344 rats, and its hydroxylation and conjugation by human CYP450s and UDP-glucuronosyltransferases	0	0
12456	7	12140 2000 JOURNAL OF HEPATOLOGY 33(2):216-223 Krahenbuhl L; Ledermann M; Lang C; Krahenbuhl S Relationship between hepatic mitochondrial functions in vivo and in vitro in rats with carbon tetrachloride-induced liver cirrhosis	3	0
12457	11	12141 2000 JOURNAL OF INORGANIC BIOCHEMISTRY 81(3):153-160 Raner GM; Hatchell AJ; Morton PE; Ballou DP; Coon MJ Stopped-flow spectrophotometric analysis of intermediates in the peroxo-dependent inactivation of cytochrome P450 by aldehydes	3	0
12458	6	12149 2000 JOURNAL OF NUTRITION 130(9):2367-2370 Stupans I; Stretch G; Hayball P Olive oil phenols inhibit human hepatic microsomal activity	11	0
12459	3	12150 2000 JOURNAL OF ORGANIC CHEMISTRY 65(14):4460-4463 Rosen GM; Tsai P; Barth ED; Dorey G; Casara P; Spedding M; Halpern HJ A one-step synthesis of 2-(2-pyridyl)-3H-indol-3-one N-oxide: Is it an efficient spin trap for hydroxyl radical?	8	0
12460	3	12152 2000 JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 13(5):483-488 Saraco N; Berensztein E; Dardis A; Rivarola MA; Belgorosky A Expression of the aromatase gene in the human prepubertal testis	1	0
12461	12	12153 2000 JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 13():1271-1275 Auchus RJ; Geller DH; Lee TC; Worthy KM The function and roles of P450c17 in androgen excess states	2	0
12462	8	12154 2000 JOURNAL OF PHARMACEUTICAL SCIENCES 89(8):1022-1027 Brunner LJ; Bai S Effect of dietary oil intake on hepatic cytochrome p450 activity in the rat	0	0
12463	11	12157 2000 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 292(3):1008-1014 Sindhu RK; Mitsuhashi M; Kikkawa Y Induction of cytochrome P-450 1A2 by oxidized tryptophan in Hepa lclc7 cells	3	0
12464	4	12158 2000 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 293(2):494-500 Abraham NG; Jiang SL; Yang LM; Zand BA; Laniado-Schwartzman M; Marji J; Drummond GS; Kappas A Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity	11	0
12465	13	12163 2000 JOURNAL OF PLANT RESEARCH 113(1112):475-488 Aoki T; Akashi T; Ayabe S Flavonoids of leguminous plants: Structure, biological activity, and biosynthesis	4	0
12466	19	12164 2000 JOURNAL OF PROTEIN CHEMISTRY 19(1):23-32 Omata Y; Dai RK; Smith SV; Robinson RC; Friedman FK Synthetic peptide mimics of a predicted topographical interaction surface: The cytochrome P4502B1 recognition domain for NADPH-cytochrome P450 reductase	1	0
12467	6	12165 2000 JOURNAL OF PSYCHIATRY & NEUROSCIENCE 25(5):481-496 Baker GB; Coutts RT; Greenshaw AJ Neurochemical and metabolic aspects of antidepressants: an overview	2	0
12468	3	12168 2000 JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (3):253-273 Durand S; Parrain JL; Santelli M Construction of (Z,Z) skipped 1,4-dienes. Application to the synthesis of polyunsaturated fatty acids and derivatives	8	0
12469	4	12169 2000 JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 5():983-988 Tsai P; Porasuphatana S; Pou S; Rosen GM Investigations into the spin trapping of nitric oxide and superoxide: models to explore free radical generation by nitric oxide synthase	0	0
12470	3	12170 2000 LANCET 355(9208):945-946 Park BK Cytochrome P450 enzymes in the heart	2	0
12471	5	12171 2000 LANGMUIR 16(7):3414-3421 Kloss AA; Lavrik N; Yeung C; Leckband D Effect of the microenvironment on the recognition of immobilized cytochromes by soluble redox proteins	5	0
12472	9	12172 2000 LIFE SCIENCES 66(20):1955-1967 Fujita K; Mogami A; Hayashi A; Kamataki T Establishment of Salmonella strain expressing catalytically active human UDP-glucuronosyltransferase 1A1 (UGT1A1)	0	0
12473	13	12177 2000 MARINE BIOTECHNOLOGY 2(2):167-172 Aoki J; Sato M; Itakura T An eel cytochrome P450 1A gene having no XRE sequences in its 5 ' upstream region of 1600 bp	1	0
12474	7	12180 2000 MEDICINA CLINICA 114(4):121-127 Fernandez J; Montemayor T; Bautista J; Marquez R; Jimenez L; Arenas J; Campos Y; Castillo J Role of cardiopulmonary exercise test in patients with mitochondrial myopathies	2	0
12475	7	12182 2000 METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 22(9):695-705 Isaza CA; Henao J; Lopez AM; Cacabelos R Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population	1	0
12476	14	12183 2000 MOLECULAR AND CELLULAR ENDOCRINOLOGY 164(1-2):169-181 Ijiri S; Berard C; Trant JM Characterization of gonadal and extra-gonadal forms of the cDNA encoding the Atlantic stingray (Dasyatis sabina) cytochrome P450 aromatase (CYP19)	5	0
12477	1	12184 2000 MOLECULAR BIOLOGY 34(3):351-355 Schwartz EI; Duzhak TG; Gulyaeva LF; Lyakhovich VV Effect of inducers on the interaction of the positive and negative cis-acting elements of the CYP2B2 gene with rat liver nuclear proteins	0	0
12478	65	12185 2000 MOLECULAR BIOTECHNOLOGY 16(3):233-251 Imig JD Epoxygenase metabolites - Epithelial and vascular actions	3	0
12479	2	12186 2000 MOLECULAR BRAIN RESEARCH 78(1-2):38-49 Oyan AM; Nilsen F; Goksoyr A; Holmqvist B Partial cloning of constitutive and inducible nitric oxide synthases and detailed neuronal expression of NOS mRNA in the cerebellum and optic tectum of adult Atlantic salmon (Salmo salar)	7	0
12480	4	12191 2000 MUTAGENESIS 15(1):9-15 Jensen KG; Wiberg K; Klasson-Wehler E; Onfelt A Induction of aberrant mitosis with PCBs: particular efficiency of 2,3,3 ',4,4 '-pentachlorobiphenyl and synergism with triphenyltin	0	0
12481	8	12195 2000 NEUROCHEMISTRY INTERNATIONAL 36(4-5):451-459 McKenna MC; Stevenson JH; Huang XL; Tildon JT; Zielke CL; Hopkins IB Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells	15	0
12482	4	12198 2000 NEUROLOGIC CLINICS 18(1):15-+ Taivassalo T; Reddy H; Matthews PM Muscle responses to exercise in health and disease	1	0
12483	8	12200 2000 NEW MEDICATIONS FOR DRUG ABUSE 909():233-246 Sellers EM; Tyndale RF Mimicking gene defects to treat drug dependence	7	0
12484	7	12201 2000 NUCLEIC ACIDS RESEARCH 28(5):1126-1132 Kim J; Rivera-Rivera I; Kemper B Tissue-specific chromatin structure of the phenobarbital- responsive unit and proximal promoter of CYP2B1/2 and modulation by phenobarbital	4	0
12485	4	12202 2000 ONCOGENE 19(21):2585-2597 Herrington J; Smit LS; Schwartz J; Carter-Su C The role of STAT proteins in growth hormone signaling	29	0
12486	7	12203 2000 OTOLARYNGOLOGY-HEAD AND NECK SURGERY 123(1):1-8 Sherman BE; Chole RA Effects of leukotriene and cyclo-oxygenase inhibition on adaptive bone remodeling in the middle ear	0	0
12487	8	12204 2000 PARASITOLOGY 120():399-407 Lockyer AE; Jones CS; Noble LR; Rollinson D Use of differential display to detect changes in gene expression in the intermediate snail host Biomphalaria glabrata upon infection with Schistosoma mansoni	9	0
12488	2	12205 2000 PATHOLOGY INTERNATIONAL 50(5):353-362 Kitano M Host genes controlling the susceptibility and resistance to squamous cell carcinoma of the tongue in a rat model	0	0
12489	10	12207 2000 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 68(1):11-25 Yamada T; Kambara Y; Imaishi H; Ohkawa H Molecular cloning of novel cytochrome P450 species induced by chemical treatments in cultured tobacco cells	4	0
12490	15	12212 2000 PHARMACOLOGY 61(3):147-153 Kimura S; Gonzalez F Applications of genetically manipulated mice in pharmacogenetics and pharmacogenomics	5	0
12491	41	12214 2000 PHARMACOLOGY & THERAPEUTICS 86(1):1-28 Nakagawa K; Ishizaki T Therapeutic relevance of pharmacogenetic factors in cardiovascular medicine	9	0
12492	5	12216 2000 PHARMACOLOGY & TOXICOLOGY 87(4):174-178 Skaanild MT; Friis C Expression changes of CYP2A and CYP3A in microsomes from pig liver and cultured hepatocytes	2	0
12493	6	12217 2000 PHARMACOTHERAPY 20(8):139S-151S Cloyd JC; Remmel RP Antiepileptic drug pharmacokinetics and interactions: Impact on treatment of epilepsy	8	0
12494	3	12218 2000 PHARMACOTHERAPY 20(3):280-291 Higa GM Altering the estrogenic milieu of breast cancer with a focus on the new aromatase inhibitors	1	0
12495	3	12220 2000 PHYTOCHEMISTRY 53(3):319-323 Utsunomiya Y; Nakayama T; Oohira H; Hirota R; Mori T; Kawai F; Ueda T Purification and inactivation by substrate of an allene oxide synthase (CYP74) from corn (Zea mays L.) seeds	5	0
12496	4	12221 2000 PHYTOTHERAPY RESEARCH 14(1):43-44 Hagymasi K; Blazovics A; Feher J; Lugasi A; Kristo ST; Kery A The in vitro effect of dandelions antioxidants on microsomal lipid peroxidation	2	0
12497	18	12222 2000 PLANT MOLECULAR BIOLOGY 44(2):141-153 Tranbarger TJ; Forward BS; Misra S Regulation of NADPH-cytochrome P450 reductase expressed during Douglas-fir germination and seedling development	0	0
12498	18	12223 2000 PLANT PHYSIOLOGY 122(4):1311-1321 Nielsen JS; Moller BL Cloning and expression of cytochrome P450 enzymes catalyzing the conversion of tyrosine to p-hydroxyphenylacetaldoxime in the biosynthesis of cyanogenic glucosides in Triglochin maritima	9	0
12499	1	12224 2000 PLASMID 43(1):35-48 Stockwell D; Lelianova V; Thompson T; Dempsey WB Transcription of the transfer genes traY and traM of the antibiotic resistance plasmid R100-1 is linked	0	0
12500	5	12225 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(1):331-336 Tiffert T; Ginsburg H; Krugliak M; Elford BC; Lew VL Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum	9	0

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