#	Cited nodes	Nodes / Authors	GCS	LCS
8601	11	10969 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 350(2):233-238 Chen CD; Doray B; Kemper B A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2	4	1
8602	5	10986 1998 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357(1):137-146 Andreou ER; Prokipcak RD Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction	7	1
8603	8	11008 1998 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 244(1):110-114 Lamb DC; Kelly DE; Hanley SZ; Mehmood Z; Kelly SL Glyphosate is an inhibitor of plant cytochrome P450: Functional expression of Thlaspi arvensae cytochrome P45071B1/Reductase fusion protein in Escherichia coli	4	1
8604	3	11011 1998 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 246(3):711-718 Arora V; Iversen PL; Ebadi M Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides	13	1
8605	13	11032 1998 BIOCHEMICAL PHARMACOLOGY 55(11):1861-1871 Stresser DM; Kupfer D Prosubstrates of CYP3A4, the major human hepatic cytochrome P450 - Transformation into substrates by other P450 isoforms	6	1
8606	9	11042 1998 BIOCHEMISTRY 37(13):4317-4324 Contzen J; Jung C Step-scan time-resolved FTIR spectroscopy of cytochrome P- 450(cam) carbon monoxide complex: A salt link involved in the ligand-rebinding process	13	1
8607	8	11044 1998 BIOCHEMISTRY 37(19):7039-7046 Higgins L; Bennett GA; Shimoji M; Jones JP Evaluation of cytochrome P450 mechanism and kinetics using kinetic deuterium isotope effects	13	1
8608	6	11051 1998 BIOCHEMISTRY 37(38):13184-13193 Koenigs LL; Trager WF Mechanism-based inactivation of cytochrome P450 2B1 by 8- methoxypsoralen and several other furanocoumarins	18	1
8609	6	11055 1998 BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL 45(1):115-123 Tsukamoto M; Tampo Y; Yonaha M Lucigenin reduction by NADPH-cytochrome P450 reductase and the effect of phospholipids and albumin on chemiluminescence	4	1
8610	5	11063 1998 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1398(3):243-255 Tully RE; van Berkum P; Lovins KW; Keister DL Identification and sequencing of a cytochrome P450 gene cluster from Bradyrhizobium japonicum	6	1
8611	18	11066 1998 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1381(1):12-26 Yawetz A; Woodin BR; Stegeman JJ Cytochromes P450 in liver of the turtle Chrysemys picta picta and the induction and partial purification of CYP1A-like proteins	5	1
8612	7	11067 1998 BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM 1390(2):197-206 Tsubaki M; Matsumoto N; Tomita S; Ichikawa Y; Hori H 20 beta-hydroxy-C21-steroid 20 beta-oxidase activity of cytochrome P450(c21) purified from bovine adrenocortical microsomes	1	1
8613	6	11075 1998 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62(7):1403-1411 Yamada T; Imaishi H; Oka A; Ohkawa H Molecular cloning and expression in Saccharomyces cerevisiae of tobacco NADPH-cytochrome P450 oxidoreductase cDNA	2	1
8614	21	11080 1998 BRITISH JOURNAL OF CANCER 77(11):1768-1776 Brain EGC; Yu LJ; Gustafsson K; Drewes P; Waxman DJ Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo	15	1
8615	12	11081 1998 BRITISH JOURNAL OF CANCER 78(9):1170-1174 Ando Y; Shimizu T; Nakamura K; Mushiroda T; Nakagawa T; Kodama T; Kamataki T Potent and non-specific inhibition of cytochrome P450 by JM216, a new oral platinum agent	2	1
8616	7	11083 1998 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 45(4):369-375 Andersson T; Holmberg J; Rohss K; Walan A Pharmacokinetics and effect an caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole	30	1
8617	8	11090 1998 CANCER CHEMOTHERAPY AND PHARMACOLOGY 42(1):1-8 Ohtsu T; Fujii H; Wakita H; Igarashi T; Itoh K; Imoto S; Kohagura M; Sasaki Y Pharmacokinetic study of low- versus high-dose medroxyprogesterone acetate (MPA) in women	4	1
8618	13	11092 1998 CANCER LETTERS 122(1-2):51-59 Yamane M; Shimizu S; Abe A; Yamane S Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2	2	1
8619	14	11117 1998 CHEMICO-BIOLOGICAL INTERACTIONS 116(1-2):123-141 Eliasson E; Gardner I; Hume-Smith H; de Waziers I; Beaune P; Kenna JG Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis	9	1
8620	2	11125 1998 CLINICAL ENDOCRINOLOGY 48(6):707-711 Rumsby G; Avey CJ; Conway GS; Honour JW Genotype-phenotype analysis in late onset 21-hydroxylase deficiency in comparison to the classical forms	20	1
8621	11	11127 1998 CLINICAL PHARMACOLOGY & THERAPEUTICS 64(1):8-17 Adedoyin A; Arns PA; Richards WO; Wilkinson GR; Branch RA Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6	17	1
8622	9	11141 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):173-179 Lee RF Annelid cytochrome P-450	9	1
8623	6	11146 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):305-310 Perkins EJ; Schlenk D Immunochemical characterization of hepatic cytochrome P450 isozymes in the channel catfish: assessment of sexual, developmental and treatment-related effects	8	1
8624	10	11148 1998 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 121(1-3):361-369 Peters LD; Nasci C; Livingstone DR Immunochemical investigations of cytochrome P450 forms/epitopes (CYP1A, 2B, 2E, 3A and 4A) in digestive gland of Mytilus sp	14	1
8625	6	11170 1998 DRUG METABOLISM AND DISPOSITION 26(4):318-323 Takedomi S; Matsuo H; Yamano K; Yamamoto K; Iga T; Sawada Y Quantitative prediction of the interaction of midazolam and histamine H-2 receptor antagonists in rats	10	1
8626	28	11172 1998 DRUG METABOLISM AND DISPOSITION 26(5):483-489 Amato G; Longo V; Mazzaccaro A; Gervasi PG Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver	9	1
8627	8	11177 1998 DRUG METABOLISM AND DISPOSITION 26(10):970-976 Machinist JM; Mayer MD; Roberts EM; Surber BW; Rodrigues AD Identification of the human liver cytochrome P450 enzymes involved in the in vitro metabolism of a novel 5-lipoxygenase inhibitor	2	1
8628	3	11184 1998 DRUG METABOLISM REVIEWS 30(4):645-674 Miller JA The metabolism of xenobiotics to reactive electrophiles in chemical carcinogenesis and mutagenesis: A collaboration with Elizabeth Cavert Miller and our associates	5	1
8629	13	11196 1998 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 17(3):439-445 Lin S; Bullock PL; Addison RF; Bandiera SM Detection of cytochrome P4501A in several species using antibody against a synthetic peptide derived from rainbow trout cytochrome P4501A1	9	1
8630	2	11197 1998 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 17(12):2395-2407 Tietge JE; Johnson RD; Jensen KM; Cook PM; Elonen GE; Fernandez JD; Holcombe GW; Lothenbach DB; Nichols JW Reproductive toxicity and disposition of 2,3,7,8- tetrachlorodibenzo-p-dioxin in adult brook trout (Salvelinus fontinalis) following a dietary exposure	14	1
8631	7	11198 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 5(1):29-34 Eke BC; Coban T; Vural N; Iscan M Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats	1	1
8632	12	11199 1998 ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 5(3):179-196 Seidel A; Soballa VJ; Raab G; Frank H; Greim H; Grimmer G; Jacob J; Doehmer J Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450	11	1
8633	5	11211 1998 EUROPEAN NEUROLOGY 39(2):65-71 Argov Z Functional evaluation techniques in mitochondrial disorders	7	1
8634	6	11225 1998 FISH PHYSIOLOGY AND BIOCHEMISTRY 18(1):49-57 Wang WD; Chen YM; Hu CH Detection of Ah receptor and Ah receptor nuclear translocator mRNAs in the oocytes and developing embryos of zebrafish (Danio rerio)	24	1
8635	5	11234 1998 GENERAL AND COMPARATIVE ENDOCRINOLOGY 111(2):141-155 Ponthier JL; Shackleton CHL; Trant JM Seasonal changes in the production of two novel and abundant ovarian steroids in the channel catfish (Ictalurus punctatus)	6	1
8636	9	11242 1998 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 28(1):1-9 Scharf ME; Neal JJ; Marcus CB; Bennett GW Cytochrome P450 purification and immunological detection in an insecticide resistant strain of German cockroach (Blattella germanica, L.)	9	1
8637	7	11248 1998 JAPANESE JOURNAL OF CANCER RESEARCH 89(10):1028-1032 Yokose T; Doy M; Kakiki M; Horie T; Matsuzaki Y; Mukai K Expression of cytochrome P450 3A4 in foveolar epithelium with intestinal metaplasia of the human stomach	3	1
8638	8	11249 1998 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 46(7):2707-2713 Kuilman MEM; Maas RFM; Judah DJ; Fink-Gremmels J Bovine hepatic metabolism of aflatoxin B-1	5	1
8639	10	11253 1998 JOURNAL OF BIOCHEMISTRY 124(3):503-508 Yamamoto Y; Ishizuka M; Takada A; Fujita S Cloning, tissue distribution, and functional expression of two novel rabbit cytochrome P450 isozymes, CYP2D23 and CYP2D24	4	1
8640	6	11259 1998 JOURNAL OF BIOLOGICAL CHEMISTRY 273(11):6163-6165 Nikoshkov A; Lajic S; Vlamis-Gardikas A; Tranebjaerg L; Holst M; Wedell A; Luthman H Naturally occurring mutants of human steroid 21-hydroxylase (P450c21) pinpoint residues important for enzyme activity and stability	15	1
8641	3	11274 1998 JOURNAL OF CELL BIOLOGY 140(5):1091-1099 Kuznetsov AV; Mayboroda O; Kunz D; Winkler K; Schubert W; Kunz WS Functional imaging of mitochondria in saponin-permeabilized mice muscle fibers	22	1
8642	6	11278 1998 JOURNAL OF CHROMATOGRAPHY B 717(1-2):201-245 Tsikas D Application of gas chromatography mass spectrometry and gas chromatography tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans	21	1
8643	1	11279 1998 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 83(2):448-452 Erden HF; Zwain IH; Asakura H; Yen SSC Corticotropin-releasing factor inhibits luteinizing hormone- stimulated P450c17 gene expression and androgen production by isolated thecal cells of human ovarian follicles	8	1
8644	4	11290 1998 JOURNAL OF HEART AND LUNG TRANSPLANTATION 17(12):1231-1237 Tirdel GB; Girgis R; Fishman RS; Theodore J Metabolic myopathy as a cause of the exercise limitation in lung transplant recipients	12	1
8645	2	11295 1998 JOURNAL OF MOLECULAR MODELING 4(7):234-238 Archakov AI; Lisitsa AV; Zgoda VG; Ivanova MS; Koymans L Clusterization of P450 superfamily using the objective pair alignment method and the UPGMA program	1	1
8646	6	11296 1998 JOURNAL OF NEUROCHEMISTRY 71(2):844-852 Vogel R; Jennemann G; Seitz J; Wiesinger H; Hamprecht B Mitochondrial malic enzyme: Purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain	15	1
8647	13	11309 1998 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 64(1-2):121-128 Katagiri M; Tatsuta K; Imaoka S; Funae Y; Honma K; Matsuo N; Yokoi H; Ishimura K; Ishibashi F; Kagawa N Evidence that immature rat liver is capable of participating in steroidogenesis by expressing 17 alpha-hydroxylase/17,20-lyase P450c17	2	1
8648	13	11317 1998 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A 54(7):509-527 Ueng TH; Hwang WP; Chen RM; Wang HW; Kuo ML; Park SS; Guengerich FP Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues	12	1
8649	10	11318 1998 KIDNEY INTERNATIONAL 54(1):216-223 Brunner LJ; Bennett WM; Koop DR Cyclosporine suppresses rat hepatic cytochrome P450 in a time- dependent manner	12	1
8650	4	11324 1998 MOLECULAR AND CELLULAR ENDOCRINOLOGY 137(1):13-19 Endoh A; Yang L; Hornsby PJ CYP21 pseudogene transcripts are much less abundant than those from the active gene in normal human adrenocortical cells under various conditions in culture	3	1
8651	27	11326 1998 MOLECULAR AND CELLULAR ENDOCRINOLOGY 145(1-2):111-121 Qin KN; Rosenfield RL Role of cytochrome P450c17 in polycystic ovary syndrome	13	1
8652	4	11332 1998 MOLECULAR PHARMACOLOGY 53(3):438-445 Reiners JJ; Lee JY; Clift RE; Dudley DT; Myrand SP PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase	36	1
8653	9	11333 1998 MOLECULAR PHARMACOLOGY 53(3):475-482 Hellmold H; Magnusson M; Pelto-Huikko M; Rylander T; Gustafsson JA; Warner M Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal rat breast	4	1
8654	17	11343 1998 NERVENARZT 69(11):944-955 Normann C; Hesslinger B; Bauer J; Berger M; Walden J The role of the hepatic cytochrome P450 enzymes in psychopharmacology	7	1
8655	4	11348 1998 NEUROSCIENCE LETTERS 247(2-3):123-126 Vogel R; Hamprecht B; Wiesinger H Malic enzyme isoforms in astrocytes: comparative study on activities in rat brain tissue and astroglia-rich primary cultures	5	1
8656	7	11351 1998 NUCLEIC ACIDS RESEARCH 26(8):1959-1964 Chin KK; Chang SF The (-104)G nucleotide of the human CYP21 gene is important for CYP21 transcription activity and protein interaction	3	1
8657	3	11357 1998 PHARMACEUTICAL RESEARCH 15(8):1189-1195 Joshi R; Arora V; Desjardins JP; Robinson D; Himmelstein KJ; Iversen PL In vivo properties of an in situ forming gel for parenteral delivery of macromolecular drugs	6	1
8658	16	11361 1998 PHARMACOGENETICS 8(3):211-225 Leeder JS; Lu XL; Timsit Y; Gaedigk A Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions	9	1
8659	11	11371 1998 PHARMACOLOGY & TOXICOLOGY 82(2):74-79 Villard PH; Herber R; Seree EM; Attolini L; Magdalou J; Lacarelle B Effect of cigarette smoke on UDP-glucuronosyltransferase activity and cytochrome P450 content in liver, lung and kidney microsomes in mice	11	1
8660	7	11372 1998 PHARMACOLOGY & TOXICOLOGY 82(2):93-97 Hukkanen J; Mantyla M; Kangas L; Wirta P; Hakkola J; Paakki P; Evisalmi S; Pelkonen O; Raunio H Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium	13	1
8661	8	11376 1998 PHARMACOTHERAPY 18(2):381-385 Thomas AR; Chan LN; Bauman JL; Olopade CO Prolongation of the QT interval related to cisapride-diltiazem interaction	27	1
8662	4	11385 1998 PLANTA 204(1):64-69 Peters S; Schmidt W; Beerhues L Regioselective oxidative phenol couplings of 2,3 ',4,6- tetrahydroxybenzophenone in cell cultures of Centaurium erythraea RAFN and Hypericum androsaemum L.	15	1
8663	9	11397 1998 SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY 11(2):61-69 Friedberg T Molecular biological methods for characterizing drug- metabolizing enzymes in hepatic and extrahepatic tissues	1	1
8664	14	11404 1998 TOXICOLOGY 126(3):179-193 Irizar A; Ioannides C Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits	5	1
8665	8	11405 1998 TOXICOLOGY 130(2-3):79-93 Ratra GS; Morgan WA; Mullervy J; Powell CJ; Wright MC Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil	9	1
8666	9	11410 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 149(2):195-202 Watt KC; Plopper CG; Weir AJ; Tarkington B; Buckpitt AR Cytochrome P450 2E1 in rat tracheobronchial airways: Response to ozone exposure	7	1
8667	15	11413 1998 TOXICOLOGY AND APPLIED PHARMACOLOGY 151(1):166-173 Bentivegna CS; Ihnat MA; Baptiste NS; Hamilton JW Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo	7	1
8668	16	11416 1998 TOXICOLOGY IN VITRO 12(6):715-723 Monshouwer M; van't Klooster GAE; Nijmeijer SM; Witkamp RF; van Miert ASJPAM Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes	10	1
8669	21	11425 1998 XENOBIOTICA 28(2):137-152 Ong CE; Miners JO; Birkett DJ; Bhasker CR Baculovirus-mediated expression of cytochrome P4502C8 and human NADPH-cytochrome P450 reductase: optimization of protein expression	2	1
8670	12	11428 1998 XENOBIOTICA 28(3):303-312 Bergeron RM; Serron SC; Rinehart JJ; Cawley GF; Backes WL Pituitary component of the aromatic hydrocarbon-mediated expression of CYP2B and CYP2C11	7	1
8671	17	11431 1998 XENOBIOTICA 28(6):549-557 Nishibe Y; Wakabayashi M; Harauchi T; Ohno K Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver	5	1
8672	6	11435 1998 XENOBIOTICA 28(9):845-853 McKillop D; Wild MJ; Butters CJ; Simcock C Effects of propofol on human hepatic microsomal cytochrome P450 activities	13	1
8673	4	11437 1998 XENOBIOTICA 28(10):937-948 Swales NJ; Utesch D Metabolic activity of fresh and cryopreserved dog hepatocyte suspensions	10	1
8674	37	11444 1999 ADVANCED DRUG DELIVERY REVIEWS 38(1):81-97 Pasanen M The expression and regulation of drug metabolism in human placenta	7	1
8675	3	11449 1999 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 277(5):G1048-G1054 Qu W; Graves LM; Thurman RG PGE(2) stimulates O-2 uptake in hepatic parenchymal cells: involvement of the cAMP-dependent protein kinase	7	1
8676	15	11461 1999 ANALYTICAL BIOCHEMISTRY 276(1):18-26 Bournique B; Petry M; Gonsset G Usefulness of statistic experimental designs in enzymology: Example with recombinant hCYP3A4 and 1A2	3	1
8677	26	11470 1999 AQUATIC TOXICOLOGY 47(1):43-69 Courtenay SC; Grunwald CM; Kreamer GL; Fairchild WL; Arsenault JT; Ikonomou M; Wirgin II A comparison of the dose and time response of CYP1A1 mRNA induction in chemically treated Atlantic tomcod from two populations	8	1
8678	7	11471 1999 AQUATIC TOXICOLOGY 47(2):117-128 Carlsson C; Part P; Brunstrom B 7-Ethoxyresorufin O-deethylase induction in cultured gill epithelial cells from rainbow trout	6	1
8679	11	11472 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 361(2):309-314 Biagini CP; Philpot RM; Celier CM Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11	9	1
8680	13	11488 1999 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 371(2):270-276 Kurose K; Isozaki E; Tohkin M; Fukuhara M Cloning and expression analysis of a new member of the cytochrome P450, CYP2A15 from the Chinese hamster, encoding testosterone 7 alpha-hydroxylase	4	1
8681	20	11498 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 255(2):300-306 Enriquez A; Leclercq I; Farrell GC; Robertson G Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats	17	1
8682	9	11499 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 255(2):394-398 Gushchin GV; Gushchin MI; Gerber N; Boyd RT A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes	9	1
8683	8	11500 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 257(2):384-390 Lajic S; Nikoshkov A; Holst M; Wedell A Effects of missense mutations and deletions on membrane anchoring and enzyme function of human steroid 21-hydroxylase (P450c21)	5	1
8684	9	11516 1999 BIOCHEMICAL PHARMACOLOGY 57(8):951-954 Elkahwaji J; Robin MA; Berson A; Tinel M; Letteron P; Labbe G; Beaune P; Elias D; Rougier P; Escudier B; Duvillard P; Pessayre D Decrease in hepatic cytochrome P450 after interleukin-2 Immunotherapy	9	1
8685	13	11526 1999 BIOCHEMISTRY 38(37):12180-12186 Doray B; Chen CD; Kemper B Substitutions in the C-terminal portion of the catalytic domain partially reverse assembly defects introduced by mutations in the N-terminal linker sequence of cytochrome P4502C2	1	1
8686	16	11532 1999 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1446(3):438-442 Tohkin M; Kurose K; Isozaki E; Fukuhara M Molecular cloning, heterologous expression, and characterization of a novel member of CYP2A in the Syrian hamster	1	1
8687	18	11535 1999 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1430(1):95-102 Hsu NC; Guzov VM; Hsu LC; Chung BC Characterization of the consequence of a novel Glu-380 to Asp mutation by expression of functional P450c21 in Escherichia coli	2	1
8688	14	11540 1999 BIOMARKERS 4(6):425-441 Peters LD; Shaw JP; Nott M; O'Hara SCM; Livingstone DR Development of cytochrome P450 as a biomarker of organic pollution in Mytilus sp.: field studies in United Kingdom ('Sea Empress' oil spill) and the Mediterranean Sea	7	1
8689	2	11541 1999 BIOORGANIC & MEDICINAL CHEMISTRY 7(8):1487-1496 Ahmed S A novel molecular modelling study of inhibitors of the 17 alpha-hydroxylase component of the enzyme system 17 alpha- hydroxylase/17,20-lyase (P-450(17 alpha))	2	1
8690	3	11552 1999 BRITISH JOURNAL OF PHARMACOLOGY 126(7):1531-1533 Thomas GP; Karmazyn M; Zygmunt AC; Antzelevitch C; Narayanan N The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes	7	1
8691	29	11574 1999 CHEMICKE LISTY 93(4):229-237 Stiborova M; Hudecek I; Hodek P; Frei E Cytochromes P450 and human health	3	1
8692	10	11577 1999 CHEMISTRY & BIOLOGY 6(10):R269-R272 Roberts GCK The power of evolution: accessing the synthetic potential of P450s	4	1
8693	11	11584 1999 CLINICAL PHARMACOLOGY & THERAPEUTICS 65(4):369-376 Martinez C; Albet C; Agundez JAG; Herrero E; Carrillo JA; Marquez M; Benitez J; Ortiz JA Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H-2-receptor antagonists	16	1
8694	6	11585 1999 CLINICAL PHARMACOLOGY & THERAPEUTICS 66(2):110-117 Hamaoka N; Oda Y; Hase I; Mizutani K; Nakamoto T; Ishizaki T; Asada A Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study	15	1
8695	10	11587 1999 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 124(1):89-100 Neunaber R; Achazi RK A novel, endogenous inhibitor of 7-ethoxyresorufin-O-deethylase activity isolated from liver cytosolic fractions of bream (Abramis brama L.)	1	1
8696	8	11588 1999 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 122(2):205-210 Levine SL; Oris JT Noncompetitive mixed-type inhibition of rainbow trout CYP1A catalytic activity by clotrimazole	2	1
8697	5	11591 1999 CRITICAL CARE CLINICS 15(2):297-+ Weaver LK Carbon monoxide poisoning	12	1
8698	30	11592 1999 CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES 36(4):329-363 Stratakis CA; Rennert OM Congenital adrenal hyperplasia: Molecular genetics and alternative approaches to treatment	8	1
8699	2	11598 1999 DIABETES 48(12):2437-2445 Shinozaki K; Kashiwagi A; Nishio Y; Okamura T; Yoshida Y; Masada M; Toda N; Kikkawa R Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O-2(-) imbalance in insulin-resistant rat aorta	60	1
8700	16	11605 1999 DRUG METABOLISM AND DISPOSITION 27(2):288-296 Bourrie M; Meunier V; Berger Y; Fabre G Role of cytochrome P-4502C9 in irbesartan oxidation by human liver microsomes	22	1

#	Cited nodes	Nodes / Authors	GCS	LCS
8701	12	11618 1999 DRUG METABOLISM AND DISPOSITION 27(12):1512-1518 Hosagrahara VP; Hansen LK; Remmel RP Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: Preliminary evidence for CYP3A isoforms in pigs	5	1
8702	16	11627 1999 DRUG METABOLISM REVIEWS 31(2):503-522 Waxman DJ; Chen L; Hecht JED; Jounaidi Y Cytochrome P450-based cancer gene therapy: Recent advances and future prospects	24	1
8703	7	11630 1999 DRUG METABOLISM REVIEWS 31(4):971-997 Baliga R; Ueda N; Walker PD; Shah SV Oxidant mechanisms in toxic acute renal failure	36	1
8704	13	11634 1999 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 43(3):252-260 Scholz S; Segner H Induction of CYP1A in primary cultures of rainbow trout (Oncorhynchus mykiss) liver cells: Concentration-response relationships of four model substances	11	1
8705	8	11635 1999 ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 44(1):118-128 Bols NC; Schirmer K; Joyce EM; Dixon DG; Greenberg BM; Whyte JJ Ability of polycyclic aromatic hydrocarbons to induce 7- ethoxyresorufin-o-deethylase activity in a trout liver cell line	27	1
8706	16	11637 1999 ENDOCRINOLOGY 140(12):5609-5618 Hu MC; Chou SJ; Huang YY; Hsu NC; Li H; Chung BC Tissue-specific, hormonal, and developmental regulation of SCC- LacZ expression in transgenic mice leads to adrenocortical zone characterization	14	1
8707	23	11639 1999 ENVIRONMENTAL HEALTH PERSPECTIVES 107():37-47 Hirvonen A Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer	27	1
8708	1	11647 1999 EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY 80(1):22-27 Wang H; Hiatt WR; Barstow TJ; Brass EP Relationships between muscle mitochondrial DNA content, mitochondrial enzyme activity and oxidative capacity in man: alterations with disease	15	1
8709	19	11653 1999 EUROPEAN JOURNAL OF BIOCHEMISTRY 264(1):19-26 Posti K; Leinonen S; Tetri S; Kottari S; Viitala P; Pelkonen O; Raunio H Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases	4	1
8710	4	11655 1999 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 55(5):341-347 Bonnabry P; Sievering J; Leemann T; Dayer P Quantitative drug interactions prediction system (Q-DIPS): a computer-based prediction and management support system for drug metabolism interactions	6	1
8711	8	11657 1999 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 24(2):141-147 Zhang W; Parentau H; Greenly RL; Metz CA; Aggarwal S; Wainer IW; Tracy TS Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase	5	1
8712	14	11658 1999 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 24(3):243-248 Czekaj P; Nowaczyk-Dura G Inhibiting effect of ethinylestradiol/levonorgestrel combination on microsomal enzymatic activities in rat liver and kidney	1	1
8713	11	11676 1999 FREE RADICAL BIOLOGY AND MEDICINE 27(11-12):1267-1275 Nguyen NSD; Cottet-Maire F; Buetler TM; Lo Russo A; Krauskopf AS; Armstrong JM; Vickers AEM; Mace K; Ruegg UT Metabolism-dependent stimulation of reactive oxygen species and DNA synthesis by cyclosporin A in rat smooth muscle cells	7	1
8714	4	11678 1999 GENE 226(2):327-338 Lundqvist E; Johansson I; Ingelman-Sundberg M Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes	25	1
8715	6	11688 1999 INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 29(8):667-673 Lu KH; Bradfield JY; Keeley LL Juvenile hormone inhibition of gene expression for cytochrome P4504C1 in adult females of the cockroach, Blaberus discoidalis	2	1
8716	12	11703 1999 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 13(1):1-9 Sidhu JS; Omiecinski CJ Insulin-mediated modulation of cytochrome p450 gene induction profiles in primary rat hepatocyte cultures	4	1
8717	7	11729 1999 JOURNAL OF CHROMATOGRAPHY B 734(1):73-81 Testino SA; Ozarowski J; Thurston AW; Arrendale RF; Patonay G Determination of testosterone and 6 beta-hydroxytestosterone by gas chromatography-selected ion monitoring-mass spectrometry for the characterization of cytochrome p450 3A activity	3	1
8718	13	11737 1999 JOURNAL OF ENZYME INHIBITION 14(3):175-+ Lewis DFV; Wiseman A; Tarbit MH Molecular modelling of lanosterol 14 alpha-demethylase (CYP51) from Saccharomyces cerevisiae via homology with CYP102, a unique bacterial cytochrome P450 isoform: Quantitative structure-activity relationships (QSARs) within two related series of antifungal azole derivatives	9	1
8719	6	11738 1999 JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY 233(2):285-300 Schroder HC; Batel R; Lauenroth S; Hassanein HMA; Lacorn M; Simat T; Steinhart H; Muller WEG Induction of DNA damage and expression of heat shock protein HSP70 by polychlorinated biphenyls in the marine sponge Suberites domuncula Olivi	10	1
8720	10	11742 1999 JOURNAL OF LABORATORY AND CLINICAL MEDICINE 134(2):133-140 Finnstrom N; Bjelfman C; Thorn M; Loof L; Rane A Quantitation of cytochrome P450 mRNAs in patients with suspected liver diseases as assessed by reverse transcriptase- polymerase chain reaction	4	1
8721	25	11743 1999 JOURNAL OF LIPID RESEARCH 40(11):1990-1997 Adas F; Salaun JP; Berthou F; Picart D; Simon B; Amet Y Requirement for omega and (omega-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11	4	1
8722	7	11750 1999 JOURNAL OF PATHOLOGY 188(2):197-200 Hutson JL; Wickramasinghe SN Expression of CYP2E1 by human monocyte-derived macrophages	2	1
8723	14	11753 1999 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 288(3):928-937 Yu LJ; Drewes P; Gustafsson K; Brain EGC; Hecht JED; Waxman DJ In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: Impact on pharmacokinetics and antitumor activity	20	1
8724	2	11771 1999 LANGMUIR 15(20):6829-6836 Yeung C; Purves T; Kloss AA; Kuhl TL; Sligar S; Leckband D Cytochrome c recognition of immobilized, orientational variants of cytochrome b(5): Direct force and equilibrium binding measurements	12	1
8725	9	11777 1999 MARINE BIOTECHNOLOGY 1(4):342-345 Ogino Y; Itakura T; Mitsuo R; Sato M Induction of two forms of eel cytochrome P450 1A genes by 3- methylcholanthrene	2	1
8726	10	11779 1999 MARINE BIOTECHNOLOGY 1(4):364-370 Ogino Y; Itakura T; Kato H; Aoki J; Sato M Functional analysis of promoter region from eel cytochrome P450 1A1 gene in transgenic medaka	2	1
8727	10	11780 1999 MARINE BIOTECHNOLOGY 1(4):371-375 Aoki J; Itakura T; Kato H; Sato M Isolation and sequence analysis of the eel cytochrome P450 1A1 gene	1	1
8728	10	11783 1999 MOLECULAR AND CELLULAR BIOCHEMISTRY 192(1-2):53-61 Engels W; van Bilsen M; Wolffenbuttel BHR; van der Vusse GJ; Glatz JFC Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid binding protein content in liver, heart and kidney of the diabetic rat	9	1
8729	9	11787 1999 MOLECULAR AND CELLULAR ENDOCRINOLOGY 153(1-2):183-196 Liu Z; Simpson ER Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression	18	1
8730	7	11791 1999 MOLECULAR ENDOCRINOLOGY 13(6):946-957 Nelson VL; Legro RS; Strauss JF; McAllister JM Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries	34	1
8731	8	11799 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 440(1):91-100 Lake BG; Beamand JA; Tredger JM; Barton PT; Renwick AB; Price RJ Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices	10	1
8732	5	11802 1999 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 443(1-2):235-249 Hursting SD; Kari FW The anti-carcinogenic effects of dietary restriction: mechanisms and future directions	15	1
8733	4	11808 1999 NEUROPHARMACOLOGY 38(7):979-989 Wu SN; Li HF; Jan CR; Shen AY Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH(3) cells	18	1
8734	5	11810 1999 ORAL ONCOLOGY 35(2):191-196 Tanimoto K; Hayashi S; Yoshiga K; Ichikawa T Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose	17	1
8735	5	11814 1999 PHARMACEUTICAL RESEARCH 16(6):790-798 Kong ANT; Mandlekar S; Yu R; Lei W; Fasanmande A Pharmacodynamics and toxicodynamics of drug action: Signaling in cell survival and cell death	9	1
8736	4	11828 1999 PHYTOCHEMISTRY 50(2):243-248 Bouwmeester HJ; Konings MCJM; Gershenzon J; Karp F; Croteau R Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum carvi)	7	1
8737	7	11830 1999 PLANT AND CELL PHYSIOLOGY 40(11):1182-1186 Akashi T; Fukuchi-Mizutani M; Aoki T; Ueyama Y; Yonekura-Sakakibara K; Tanaka Y; Kusumi T; Ayabe S Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones	12	1
8738	3	11834 1999 PLANT MOLECULAR BIOLOGY 40(2):237-248 Panavas T; Pikula A; Reid PD; Rubinstein B; Walker EL Identification of senescence-associated genes from daylily petals	19	1
8739	10	11848 1999 REVUE DES MALADIES RESPIRATOIRES 16(6BIS):1236-1243 Pairon JC; Housset B Biomarkers and exposure to asbestos.	3	1
8740	9	11853 1999 STEROIDS 64(3):178-186 Holland HL Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts	8	1
8741	19	11862 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 156(3):231-240 Bhagwat SV; Mullick J; Raza H; Avadhani NG Constitutive and inducible cytochromes P450 in rat lung mitochondria: Xenobiotic induction, relative abundance, and catalytic properties	10	1
8742	5	11865 1999 TOXICOLOGY AND APPLIED PHARMACOLOGY 160(1):10-20 Letcher RJ; van Holsteijn I; Drenth HJ; Norstrom RJ; Bergman A; Safe S; Pieters R; van den Berg M Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells	12	1
8743	5	11866 1999 TOXICOLOGY IN VITRO 13(4-5):633-638 Bort R; Castell JV; Pfeifer A; Gomez-Lechon MJ; Mace K High expression of human CYP2C in immortalized human liver epithelial cells	3	1
8744	12	11874 1999 XENOBIOTICA 29(3):217-229 Shiraga T; Kaneko H; Iwasaki K; Tozuka Z; Suzuki A; Hata T Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes	9	1
8745	13	11881 1999 XENOBIOTICA 29(7):703-717 Grace JM; Skanchy DJ; Aguilar AJ Metabolism of artelinic acid to dihydroqinghaosu by human liver cytochrome P4503A	7	1
8746	6	11884 1999 XENOBIOTICA 29(9):873-883 Hanioka N; Jinno H; Chung YS; Tanaka-Kagawa T; Nishimura T; Ando M Inhibition of rat hepatic cytochrome P450 activities by biodegradation products of 4-tert-octylphenol ethoxylate	7	1
8747	16	11886 1999 XENOBIOTICA 29(12):1191-1202 Nakajima M; Suzuki M; Yamaji R; Takashina H; Shimada N; Yamazaki H; Yokoi T Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds	3	1
8748	7	11889 2000 ACCOUNTS OF CHEMICAL RESEARCH 33(7):449-455 Newcomb M; Toy PH Hypersensitive radical probes and the mechanisms of cytochrome P450-catalyzed hydroxylation reactions	48	1
8749	6	11892 2000 ACTA PHYSIOLOGICA SCANDINAVICA 168(4):543-549 Harder DR; Roman RJ; Gebremedhin D Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes	6	1
8750	10	11907 2000 AQUATIC TOXICOLOGY 51(2):145-153 Teramitsu I; Yamamoto Y; Chiba I; Iwata H; Tanabe S; Fujise Y; Kazusaka A; Akahori F; Fujita S Identification of novel cytochrome P450 1A genes from five marine mammal species	4	1
8751	7	11926 2000 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 384(1):143-153 MacDonald MJ; Marshall LK Mouse lacking NAD(+)-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle	5	1
8752	10	11928 2000 ARCHIVES OF PHARMACAL RESEARCH 23(1):1-16 Kong ANT; Yu R; Chen C; Mandlekar S; Primiano T Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis	34	1
8753	11	11929 2000 ARCHIVES OF TOXICOLOGY 73(12):625-631 Hanioka N; Jinno H; Chung YS; Nishimura T; Tanaka-Kagawa T; Ando M Effect of 4-tert-octylphenol on cytochrome P450 enzymes in rat liver	3	1
8754	7	11935 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(3):677-682 Tares S; Berge JB; Amichot M Cloning and expression of cytochrome P450 genes belonging to the CYP4 family and to a novel family, CYP48, in two hymenopteran insects, Trichogramma cacoeciae and Apis mellifera	1	1
8755	10	11939 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(3):737-742 Simgen B; Contzen J; Schwarzer R; Bernhardt R; Jung C Substrate binding to 15 beta-hydroxylase (CYP106A2) probed by FT infrared spectroscopic studies of the iron ligand CO stretch vibration	4	1
8756	9	11943 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(2):762-766 LeLean JE; Moon N; Dunham WR; Coon MJ EPR spectrometry of cytochrome P4502B4: Effects of mutations and substrate binding	3	1
8757	7	11946 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279(2):708-711 Taylor M; Lamb DC; Cannell RJP; Dawson MJ; Kelly SL Cofactor recycling with immobilized heterologous cytochrome P450 105D1 (CYP105D1)	1	1
8758	16	11956 2000 BIOCHEMISTRY 39(19):5731-5737 Smith SV; Koley AP; Dai RK; Robinson RC; Leong H; Markowitz A; Friedman FK Conformational modulation of human cytochrome P450 2E1 by ethanol and other substrates: A CO flash photolysis study	6	1
8759	13	11969 2000 BIOCHEMISTRY-MOSCOW 65(12):1362-1366 Novikova LA; Nazarov PA; Saveliev AS; Drutsa VL; Sergeev VN; Miller WL; Luzikov VN Interaction of catalytic domains in cytochrome P450scc- adrenodoxin reductase-adrenodoxin fusion protein imported into yeast mitochondria	1	1
8760	10	11976 2000 BIOLOGICAL CHEMISTRY 381(7):611-614 Weitzel JM; Grott S; Radtke C; Kutz S; Seitz HJ Multiple promoters direct the tissue-specific expression of rat mitochondrial glycerol-3-phosphate dehydrogenase	4	1
8761	2	11978 2000 BIOMETALS 13(1):23-28 Sugimori D; Ichimata T; Ikeda A; Nakamura S Purification and characterization of a ferredoxin from Haloarcula japonica strain TR-1	1	1
8762	15	11985 2000 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 50(6):573-580 Ong CE; Coulter S; Birkett DJ; Bhasker CR; Miners JO The xenobiotic inhibitor profile of cytochrome P4502C8	9	1
8763	9	11987 2000 BRITISH JOURNAL OF PHARMACOLOGY 130(8):1745-1752 Thum T; Borlak J Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat	7	1
8764	18	11999 2000 CHEMICAL RESEARCH IN TOXICOLOGY 13(12):1349-1359 Goosen TC; Kent UM; Brand L; Hollenberg PF Inactivation of cytochrome P4502B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables	4	1
8765	16	12001 2000 CHEMICO-BIOLOGICAL INTERACTIONS 127(1):73-90 Narimatsu S; Kobayashi N; Masubuchi Y; Horie T; Kakegawa T; Kobayashi H; Hardwick JP; Gonzalez FJ; Shimada N; Ohmori S; Kitada M; Asaoka K; Kataoka H; Yamamoto S; Satoh T Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes	5	1
8766	7	12003 2000 CHEMOSPHERE 41(7):973-978 Hanioka N; Jinno H; Tanaka-Kagawa T; Nishimura T; Ando M Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes	5	1
8767	4	12018 2000 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 125(2):245-250 Stupans I; Kong S; Kirlich A; McKinnon RA; Murray M Testosterone dehydrogenase activity in koala liver: characterisation of cofactor and steroid substrate differences	1	1
8768	13	12020 2000 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 126(3):267-284 White RD; Shea D; Schlezinger JJ; Hahn ME; Stegeman JJ In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression	5	1
8769	80	12024 2000 CRITICAL REVIEWS IN TOXICOLOGY 30(4):347-570 Whyte JJ; Jung RE; Schmitt CJ; Tillitt DE Ethoxyresorufin-O-deethylase (EROD) activity in fish as a biomarker of chemical exposure	14	1
8770	12	12028 2000 CURRENT GENETICS 37(1):65-73 Yadav JS; Loper JC Cytochrome P450 oxidoreductase gene and its differentially terminated cDNAs from the white rot fungus Phanerochaete chrysosporium	6	1
8771	16	12036 2000 DRUG METABOLISM AND DISPOSITION 28(1):73-78 Kuriya S; Ohmori S; Hino M; Ishii I; Nakamura H; Senda C; Igarashi T; Kiuchi M; Kitada M Identification of cytochrome P-450 isoform(s) responsible for the metabolism of pimobendan in human liver microsomes	2	1
8772	14	12044 2000 DRUG METABOLISM AND DISPOSITION 28(8):905-911 Chun J; Kent UM; Moss RM; Sayre LM; Hollenberg PF Mechanism-based inactivation of cytochromes P4502B1 and P4502B6 by 2-phenyl-2-(1-piperidinyl) propane	10	1
8773	8	12045 2000 DRUG METABOLISM AND DISPOSITION 28(9):1094-1099 Coleman T; Spellman EF; Rostami-Hodjegan A; Lennard MS; Tucker GT The 1 '-hydroxylation of rac-bufuralol by rat brain microsomes	2	1
8774	12	12046 2000 DRUG METABOLISM AND DISPOSITION 28(10):1202-1209 Renwick AB; Watts PS; Edwards RJ; Barton PT; Guyonnet I; Price RJ; Tredger JM; Pelkonen O; Boobis AR; Lake BG Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices	7	1
8775	12	12048 2000 DRUG METABOLISM AND DISPOSITION 28(11):1291-1296 Matsunaga T; Kishi N; Higuchi S; Watanabe K; Ohshima T; Yamamoto I CYP3A4 is a major isoform responsible for oxidation of 7- hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-Delta(8)- tetrahydrocannabinol in human liver microsomes	4	1
8776	21	12049 2000 DRUG METABOLISM AND DISPOSITION 28(11):1311-1316 Xie Q; Zhang QY; Zhang Y; Su T; Gu J; Kaminsky LS; Ding XX Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart	2	1
8777	49	12054 2000 ENDOCRINE REVIEWS 21(3):245-291 White PC; Speiser PW Congenital adrenal hyperplasia due to 21-hydroxylase deficiency	93	1
8778	10	12060 2000 ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 19(11):2797-2805 Stagg RM; Rusin J; McPhail ME; McIntosh AD; Moffat CF; Craft JA Effects of polycyclic aromatic hydrocarbons on expression of CYP1A in salmon (Salmo salar) following experimental exposure and after the Braer oil spill	6	1
8779	7	12070 2000 EUROPEAN JOURNAL OF BIOCHEMISTRY 267(24):7209-7217 Urcelay E; Jareno MA; Menaya J; Parrilla R; Ayuso MS; Martin-Requero A Cloning and functional characterization of the 5 ' regulatory region of the human mitochondrial glycerol-3-phosphate dehydrogenase gene - Lack of 3,5,3 '-triiodothyronine responsiveness in adipose tissue	2	1
8780	7	12076 2000 EYE 14():422-428 Sarfarazi M; Stoilov I Molecular genetics of primary congenital glaucoma	17	1
8781	23	12083 2000 FRONTIERS IN NEUROENDOCRINOLOGY 21(1):1-56 Compagnone NA; Mellon SH Neurosteroids: Biosynthesis and function of these novel neuromodulators	75	1
8782	3	12093 2000 GENOMICS 70(1):49-61 Sosinsky A; Glusman G; Lancet D The genomic structure of human olfactory receptor genes	18	1
8783	14	12100 2000 INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 73(2):71-85 Indulski JA; Lutz W Metabolic genotype in relation to individual susceptibility to environmental carcinogens	4	1
8784	7	12104 2000 ISRAEL JOURNAL OF CHEMISTRY 40(1):55-62 Stevenson JA; Jones JP; Wong LL Mutations of phenylalanine-193 in the putative substrate access channel alter the substrate specificity of cytochrome P450(cam)	1	1
8785	14	12109 2000 JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 14(1):20-25 Korytko PJ; Quimby FW; Scott JG Metabolism of phenanthrene by house fly CYP6D1 and dog liver cytochrome P450	1	1
8786	13	12113 2000 JOURNAL OF BIOCHEMISTRY 128(2):189-194 Imai Y; Matsunaga I; Kusunose E; Ichihara K Unique heme environment at the putative distal region of hydrogen peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis (Peroxygenase P450(SP alpha))	3	1
8787	10	12114 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(3):1966-1975 Andersen MD; Busk PK; Svendsen I; Moller BL Cytochromes P-450 from cassava (Manihot esculenta Crantz) catalyzing the first steps in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin - Cloning, functional expression in Pichia pastoris, and substrate specificity of the isolated recombinant enzymes	17	1
8788	12	12121 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(37):28873-28881 Sandberg M; Hassett C; Adman ET; Meijer J; Omiecinski CJ Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms	8	1
8789	3	12134 2000 JOURNAL OF CHROMATOGRAPHY B 744(2):399-406 Hanioka N; Tatarazako N; Jinno H; Arizono K; Ando M Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection	5	1
8790	7	12136 2000 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 85(6):2304-2311 Wickenheisser JK; Quinn PG; Nelson VL; Legro RS; Strauss JF; McAllister JM Differential activity of the cytochrome P450 17 alpha- hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells	16	1
8791	23	12155 2000 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 44(1):313-324 Ekins S; Ring BJ; Grace J; McRobie-Belle DJ; Wrighton SA Present and future in vitro approaches for drug metabolism	22	1
8792	11	12159 2000 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 293(2):677-685 Cummings BS; Lasker JM; Lash LH Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney	9	1
8793	12	12160 2000 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 294(1):313-322 Moorthy B Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in rat hepatic and extrahepatic tissues	6	1
8794	6	12167 2000 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 122(6):1047-1056 Wirtz M; Klucik J; Rivera M Ferredoxin-mediated electrocatalytic dehalogenation of haloalkanes by cytochrome P450(cam)	6	1
8795	8	12173 2000 LIFE SCIENCES 66(22):2193-2212 Fontaine F; de Sousa G; Burcham PC; Duchene P; Rahmani R Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes	2	1
8796	1	12175 2000 LIPIDS 35(3):325-331 Williams JR The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging	12	1
8797	6	12176 2000 MAMMALIAN GENOME 11(11):1016-1023 Glusman G; Bahar A; Sharon D; Pilpel Y; White J; Lancet D The olfactory receptor gene superfamily: data mining, classification, and nomenclature	23	1
8798	6	12187 2000 MOLECULAR ENDOCRINOLOGY 14(6):875-888 Compagnone NA; Zhang P; Vigne JL; Mellon SH Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis	8	1
8799	5	12190 2000 MOLECULAR PHARMACOLOGY 58(5):976-981 Hodgkinson CP; Wright MC; Paine AJ Fibronectin-mediated hepatocyte shape change reprograms cytochrome p450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity	4	1
8800	5	12197 2000 NEUROIMMUNOMODULATION 917():971-982 Morfin R; Lafaye P; Cotillon AC; Nato F; Chmielewski V; Pompon D 7 alpha-hydroxy-dehydroepiandrosterone and immune response	4	1

#	Cited nodes	Nodes / Authors	GCS	LCS
8801	23	12206 2000 PEDIATRIC RESEARCH 47(5):677-683 Treluyer JM; Benech H; Colin I; Pruvost A; Cheron G; Cresteil T Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: Relationship with sudden infant death syndrome	7	1
8802	16	12213 2000 PHARMACOLOGY & THERAPEUTICS 85(1):11-28 Hiemke C; Hartter S Pharmacokinetics of selective serotonin reuptake inhibitors	47	1
8803	9	12215 2000 PHARMACOLOGY & TOXICOLOGY 86(5):215-221 Taavitsainen P; Anttila M; Nyman L; Karnani H; Salonen JS; Pelkonen O Selegiline metabolism and cytochrome P450 enzymes: In vitro study in human liver microsomes	10	1
8804	5	12219 2000 PHYTOCHEMISTRY 53(1):7-12 Yamamoto H; Katano N; Ooi A; Inoue K Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450	11	1
8805	2	12237 2000 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 14(17):1619-1624 Bu HZ; Magis L; Knuth K; Teitelbaum P High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites	13	1
8806	7	12246 2000 TOXICOLOGICAL SCIENCES 54(1):183-193 Ziccardi MH; Gardner IA; Denison MS Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum	15	1
8807	19	12253 2000 TOXICOLOGY AND APPLIED PHARMACOLOGY 164(1):24-37 Gannon M; Gilday D; Rifkind AB TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium	6	1
8808	16	12255 2000 TOXICOLOGY AND APPLIED PHARMACOLOGY 164(3):305-311 Serron SC; Dwivedi N; Backes WL Ethylbenzene induces microsomal oxygen free radical generation: Antibody-directed characterization of the responsible cytochrome P450 enzymes	8	1
8809	4	12260 2000 TRENDS IN PHARMACOLOGICAL SCIENCES 21(4):127-128 Zeldin DC; Liao JK Reply: cytochrome P450-derived eicosanoids and the vascular wall	4	1
8810	25	12263 2000 VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 58 58():53-87 Szklarz GD; Graham SE; Paulsen MD Molecular modeling of mammalian cytochromes P450: Application to study enzyme function	8	1
8811	3	12270 2000 XENOBIOTICA 30(3):297-306 Bach MV; Coutts RT; Baker GB Metabolism of N,N-dialkylated amphetamines, including deprenyl, by CYP2D6 expressed in a human cell line	7	1
8812	6	12271 2000 XENOBIOTICA 30(4):371-380 Tuvesson H; Strandgarden K; Nordle O; Gunnarsson PO; Seidegard J; Persson R Metabolism of roquinimex in mouse and rat: an in vitro/in vivo comparison	1	1
8813	18	12272 2000 XENOBIOTICA 30(6):547-564 Miksys S; Rao Y; Sellers EM; Kwan M; Mendis D; Tyndale RF Regional and cellular distribution of CYP2D subfamily members in rat brain	6	1
8814	12	12273 2000 XENOBIOTICA 30(6):589-607 Meunier V; Bourrie M; Julian B; Marti E; Guillou F; Berger Y; Fabre G Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up	12	1
8815	13	12276 2000 XENOBIOTICA 30(8):781-795 Price RJ; Surry D; Renwick AB; Meneses-Lorente G; Lake BG; Evans DC CYP isoform induction screening in 96-well plates: use of 7- benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes	4	1
8816	8	12277 2000 XENOBIOTICA 30(9):905-914 Tuvesson H; Wienkers LC; Gunnarsson PO; Seidegard J; Persson R Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man	1	1
8817	10	12279 2000 XENOBIOTICA 30(10):971-982 Emoto C; Yamazaki H; Yamasaki S; Shimada N; Nakajima M; Yokoi T Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro	3	1
8818	19	12283 2000 YEAST 16(12):1077-1087 Lida T; Sumita T; Ohta A; Takagi M The cytochrome P450ALK multigene family of an n-alkane- assimilating yeast, Yarrowia lipolytica: cloning and characterization of genes coding for new CYP52 family members	4	1
8819	8	12284 2001 ACTA PHARMACOLOGICA SINICA 22(3):283-288 Shu Y; Cheng ZN; Liu ZQ; Wang LS; Zhu B; Huang SL; Ou-Yang DS; Zhou HH Interindividual variations in levels and activities of cytochrome P-450 in liver microsomes of Chinese subjects	2	1
8820	16	12297 2001 ANALYTICAL BIOCHEMISTRY 292(1):115-124 Nithipatikom K; DiCamelli RF; Kohler S; Gumina RJ; Falck JR; Campbell WB; Gross GJ Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs	5	1
8821	17	12298 2001 ANALYTICAL BIOCHEMISTRY 295(2):248-256 Tachibana S; Tanaka M Simultaneous determination of testosterone metabolites in liver microsomes using column-switching semi-microcolumn high- performance liquid chromatography	2	1
8822	29	12299 2001 ANALYTICAL BIOCHEMISTRY 298(2):327-336 Nithipatikom K; Grall AJ; Holmes BB; Harder DR; Falck JR; Campbell WB Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid	9	1
8823	4	12300 2001 ANALYTICAL BIOCHEMISTRY 299(2):227-234 Watanabe T; Hammock BD Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high-performance liquid chromatography with electrospray tandem mass spectrometry	1	1
8824	33	12307 2001 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 41():815-850 Xie HG; Kim RB; Wood AJJ; Stein CM Molecular basis of ethnic differences in drug disposition and response	30	1
8825	4	12308 2001 ANTI-CANCER DRUGS 12(4):351-358 Malingre MM; Beijnen JH; Rosing H; Koopman FJ; van Tellingen O; Duchin K; Huinink WWT; Swart M; Lieverst J; Schellens JHM The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel	3	1
8826	3	12311 2001 APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 55(2):187-191 Jung Y; Kwak J; Lee Y High-level production of heme-containing holoproteins in Escherichia coli	1	1
8827	23	12319 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 387(1):117-124 Cowart LA; Falck JR; Capdevila JH Structural determinants of active site binding affinity and metabolism by cytochrome P450BM-3	1	1
8828	5	12324 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 389(2):278-287 Fitzpatrick JL; Ripp SL; Smith NB; Pierce WM; Prough RA Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions	8	1
8829	20	12326 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 390(2):222-234 Gilep AA; Guryev OL; Usanov SA; Estabrook RW Expression, purification, and physical properties of recombinant flavocytochrome fusion proteins containing rat cytochrome b(5) linked to NADPH-cytochrome P450 reductase by different membrane-binding segments	1	1
8830	26	12331 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 393(2):329-338 Aitken AE; Roman LJ; Loughran PA; de la Garza M; Masters BSS Expressed CYP4A4 metabolism of prostaglandin E-1 and arachidonic acid	2	1
8831	9	12333 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 395(1):25-31 Nakamura K; Martin MV; Guengerich FP Random mutagenesis of human cytochrome P450 2A6 and screening with indole oxidation products	3	1
8832	13	12334 2001 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 395(1):78-84 Lamb DC; Kaderbhai NN; Venkateswarlu K; Kelly DE; Kelly SL; Kaderbhai MA Human sterol 14 alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5)	1	1
8833	18	12338 2001 ARCHIVES OF TOXICOLOGY 75(6):335-345 Runge DM; Stock TW; Lehmann T; Taege C; Bernauer U; Stolz DB; Hofmann S; Foth H Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture	2	1
8834	7	12347 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284(4):937-941 Gilep AA; Guryev OL; Usanov SA; Estabrook RW An enzymatically active chimeric protein containing the hydrophilic form of NADPH-cytochrome p450 reductase fused to the membrane-binding domain of cytochrome b(5)	1	1
8835	10	12348 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 285(1):32-39 Meyer RP; Hagemeyer CE; Knoth R; Kurz G; Volk B Oxidative hydrolysis of scoparone by cytochrome P450CYP2C29 reveals a novel metabolite	1	1
8836	7	12350 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 286(2):239-242 Tamasi V; Kiss A; Dobozy O; Falus A; Vereczkey L; Monostory K The effect of dexamethasone on P450 activities in regenerating rat liver	2	1
8837	11	12353 2001 BIOCHEMICAL PHARMACOLOGY 61(2):145-153 Borlak J; Thum T Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures	6	1
8838	7	12356 2001 BIOCHEMICAL PHARMACOLOGY 62(4):407-415 Oliw EH; Stark K; Bylund J Oxidation of prostaglandin H-2 and prostaglandin H-2 analogues by human cytochromes P450: analysis of omega-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I-1 by mass spectrometry	4	1
8839	34	12357 2001 BIOCHEMICAL PHARMACOLOGY 62(5):635-645 Sivapathasundaram S; Magnisali P; Coldham NG; Howells LC; Sauer MJ; Ioannides C A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver	3	1
8840	23	12358 2001 BIOCHEMICAL SOCIETY TRANSACTIONS 29():128-135 Urban P; Jobert AS; Laine R; Pompon D Cytochrome P450 (CYP) mutants and substrate-specificity alterations: segment-directed mutagenesis applied to human CYP1A1	1	1
8841	15	12365 2001 BIOCHEMISTRY 40(24):7253-7261 Kent UM; Roberts-Kirchhoff ES; Moon N; Dunham WR; Hollenberg PF Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1	4	1
8842	13	12367 2001 BIOCHEMISTRY 40(25):7621-7629 Pikuleva IA; Puchkaev A; Bjorkhem I Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1	6	1
8843	9	12368 2001 BIOCHEMISTRY 40(38):11490-11501 Kupfer R; Liu SY; Allentoff AJ; Thompson JA Comparisons of hydroperoxide isomerase and monooxygenase activities of cytochrome P450 for conversions of allylic hydroperoxides and alcohols to epoxyalcohols and diols: Probing substrate reorientation in the active site	3	1
8844	10	12372 2001 BIOCHEMISTRY 40(45):13574-13582 Bewley MC; Marohnic CC; Barber MJ The structure and biochemistry of NADH-dependent cytochrome b(5) reductase are now consistent	3	1
8845	19	12382 2001 BIOLOGY OF THE NEONATE 80(3):193-201 Hakkola J; Raunio H; Purkunen R; Saarikoski S; Vahakangas K; Pelkonen O; Edwards RJ; Boobis AR; Pasanen M Cytochrome P450 3A expression in the human fetal liver: Evidence that CYP3A5 is expressed in only a limited number of fetal livers	4	1
8846	3	12390 2001 BRITISH JOURNAL OF CANCER 84(1):42-47 Malingre MM; Beijnen JH; Rosing H; Koopman FJ; Jewell RC; Paul EM; Huinink WWT; Schellens JHM Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients	16	1
8847	9	12391 2001 BRITISH JOURNAL OF CANCER 85(2):242-246 McFadyen MCE; Cruickshank ME; Miller ID; McLeod HL; Melvin WT; Haites NE; Parkin D; Murray GI Cytochrome P450CYP1B1 over-expression in primary and metastatic ovarian cancer	4	1
8848	3	12393 2001 CANCER CHEMOTHERAPY AND PHARMACOLOGY 47(4):347-354 Malingre MM; Beijnen JH; Rosing H; Koopman FJ; van Tellingen O; Duchin K; Huinink WWT; Swart M; Lieverst J; Schellens JHM A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A	4	1
8849	3	12394 2001 CANCER CHEMOTHERAPY AND PHARMACOLOGY 48(2):115-122 Nallani SC; Genter MB; Desai PB Increased activity of CYP3A enzyme in primary cultures of rat hepatocytes treated with docetaxel: comparative evaluation with paclitaxel	5	1
8850	11	12398 2001 CARCINOGENESIS 22(3):499-506 Teiber JF; Mace K; Hollenberg PF Metabolism of the beta-oxidized intermediates of N-nitrosodi-n- propylamine: N-nitroso-beta-hydroxypropylpropylamine and N- nitroso-beta-oxopropylpropylamine	1	1
8851	3	12401 2001 CARCINOGENESIS 22(11):1819-1824 Cauchi S; Stucker I; Solas C; Laurent-Puig P; Cenee S; Hemon D; Jacquet M; Kremers P; Beaune P; Massaad-Massade L Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer	8	1
8852	10	12403 2001 CARCINOGENESIS 22(12):2033-2038 Hatanaka N; Yamazaki H; Kizu R; Hayakawa K; Aoki Y; Iwanari M; Nakajima M; Yokoi T Induction of cytochrome P4501B1 in lung, liver and kidney of rats exposed to diesel exhaust	4	1
8853	27	12407 2001 CELLULAR AND MOLECULAR LIFE SCIENCES 58(5-6):737-747 Anzenbacher P; Anzenbacherova E Cytochromes P450 and metabolism of xenobiotics	22	1
8854	5	12415 2001 CHEST 120(2):634-+ Clay AS; Behnia M; Brown KK Mitochondrial disease - A pulmonary and critical-care medicine perspective	2	1
8855	18	12442 2001 DRUG METABOLISM AND DISPOSITION 29(3):353-360 Kim H; Putt DA; Zangar RC; Wolf CR; Guengerich FP; Edwards RJ; Hollenberg PF; Novak RF Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment	3	1
8856	14	12447 2001 DRUG METABOLISM AND DISPOSITION 29(6):798-805 Hashizume T; Mise M; Matsumoto S; Terauchi Y; Fujii T; Imaoka S; Funae Y; Kamataki T; Miyazaki H A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine	1	1
8857	3	12451 2001 DRUG METABOLISM AND DISPOSITION 29(7):1068-1072 Ishigami M; Kawabata K; Takasaki W; Ikeda T; Komai T; Ito K; Sugiyama Y Drug interaction between simvastatin and itraconazole in male and female rats	3	1
8858	11	12464 2001 ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 30(1):61-+ White PC Steroid 11 beta-hydroxylase deficiency and related disorders	7	1
8859	31	12465 2001 ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 30(1):101-+ Auchus RJ The genetics, pathophysiology, and management of human deficiencies of P450c17	2	1
8860	19	12466 2001 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 38(1):12-18 Josephy PD; Batty SM; Boverhof DR Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains	2	1
8861	31	12467 2001 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 38(4):329-338 Fujita K; Nakayama K; Yamazaki Y; Tsuruma K; Yamada M; Nohmi T; Kamataki T Construction of Salmonella typhimurium YG7108 strains, each coexpressing a form of human cytochrome P450 with NADPH- cytochrome P450 reductase	2	1
8862	12	12468 2001 ENVIRONMENTAL HEALTH PERSPECTIVES 109(1):61-66 Newman JW; Denton DL; Morisseau C; Koger CS; Wheelock CE; Hinton DE; Hammock BD Evaluation of fish models of soluble epoxide hydrolase inhibition	3	1
8863	8	12474 2001 EUROPEAN JOURNAL OF BIOCHEMISTRY 268(11):3198-3204 Zhang L; Takaya N; Kitazume T; Kondo T; Shoun H Purification and cDNA cloning of nitric oxide reductase cytochrome P450nor (CYP55A4) from Trichosporon cutaneum	5	1
8864	14	12475 2001 EUROPEAN JOURNAL OF BIOCHEMISTRY 268(14):4095-4103 Weitzel JM; Kutz S; Radtke C; Grott S; Seitz HJ Hormonal regulation of multiple promoters of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene - Identification of a complex hormone-response element in the ubiquitous promoter B	6	1
8865	75	12476 2001 EUROPEAN JOURNAL OF BIOCHEMISTRY 268(18):4817-4832 Hlavica P; Lewis DFV Allosteric phenomena in cytochrome P450-catalyzed monooxygenations	2	1
8866	9	12478 2001 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 57(5):403-409 Finnstrom N; Thorn M; Loof L; Rane A Independent patterns of cytochrome P-450 gene expression in liver and blood in patients with suspected liver disease	6	1
8867	6	12482 2001 EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 53(5):387-391 Ejiri N; Katayama KI; Nakayama H; Doi K Expression of cytochrome P450 (CYP) isozymes in rat placenta through pregnancy	1	1
8868	17	12489 2001 FUNGAL GENETICS AND BIOLOGY 33(1):37-48 George HL; VanEtten HD Characterization of pisatin-inducible cytochrome P450s in fungal pathogens of pea that detoxify the pea phytoalexin pisatin	2	1
8869	12	12493 2001 GENE 272(1-2):257-266 Wen ZM; Horak CE; Scott JG CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450s	2	1
8870	3	12495 2001 HELVETICA CHIMICA ACTA 84(1):172-179 Nezbedova L; Hesse M; Drandarov K; Werner C Prelandrine, the key-step intermediate in the biosynthesis of the macrocyclic spermine alkaloid aphelandrine	5	1
8871	5	12515 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(12):9038-9044 Grivennikova VG; Kapustin AN; Vinogradov AD Catalytic activity of NADH-ubiquinone oxidoreductase (Complex I) in intact mitochondria - Evidence for the slow active/inactive transition	9	1
8872	17	12516 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(13):9606-9612 Lundell K; Hansson R; Wikvall K Cloning and expression of a pig liver taurochenodeoxycholic acid 6 alpha-hydroxylase (CYP4A21) - A novel member of the CYP4A subfamily	3	1
8873	4	12518 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(27):24498-24505 Ebisu K; Nagasawa T; Watanabe K; Kakinuma K; Miyano K; Tamura M Fused p47(phox) and p67(phox) truncations efficiently reconstitute NADPH oxidase with higher activity and stability than the individual components	7	1
8874	9	12521 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(30):27950-27958 Hsu MH; Savas V; Griffin KJ; Johnson EF Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator- activated receptor a in HepG2 cells	24	1
8875	11	12529 2001 JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 6(5-6):523-533 Green AJ; Rivers SL; Cheesman M; Reid GA; Quaroni LG; Macdonald IDG; Chapman SK; Munro AW Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis	5	1
8876	6	12534 2001 JOURNAL OF BONE AND MINERAL RESEARCH 16(1):46-56 Panda DK; Al Kawas S; Seldin MF; Hendy GN; Goltzman D 25-hydroxyvitamin D 1 alpha-hydroxylase: Structure of the mouse gene, chromosomal assignment, and developmental expression	7	1
8877	1	12536 2001 JOURNAL OF CHROMATOGRAPHY B 757(1):143-150 Fujino H; Yamada I; Shimada S; Yoneda M Simultaneous determination of taxol and its metabolites in microsomal samples by a simple thin-layer chromatography radioactivity assay - inhibitory effect of NK-104, a new inhibitor of HMG-CoA reductase	5	1
8878	10	12537 2001 JOURNAL OF CHROMATOGRAPHY B 760(2):281-288 Whalley PM; Bakes D; Grime K; Weaver RJ Rapid high-performance liquid chromatographic method for the separation of hydroxylated testosterone metabolites	3	1
8879	4	12542 2001 JOURNAL OF HELMINTHOLOGY 75(3):259-265 Lyddiard JRA; Whitfield PJ Inhibition of Site I mitochondrial electron transport by an extract of the seeds of Millettia thonningii: a potential mechanism for the plant's molluscicidal and schistosome larvicidal activity	1	1
8880	6	12544 2001 JOURNAL OF HYPERTENSION 19(5):983-992 Imig JD; Zhao XY; Falck JR; Wei SZ; Capdevila JH Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12- epoxyeicosatrienoic acid	5	1
8881	9	12552 2001 JOURNAL OF NEUROCHEMISTRY 76(2):332-340 Rosenbrock H; Hagemeyer CE; Ditter M; Knoth R; Volk B Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain	5	1
8882	7	12555 2001 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 297(3):1166-1175 Yoshisue K; Nagayama S; Shindo T; Kawaguchi Y Effects of 5-flourouracil on the drug-metabolizing enzymes of the small intestine and the consequent drug interaction with nifedipine in rats	3	1
8883	3	12563 2001 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 123(26):6410-6416 Hata M; Hirano Y; Hoshino T; Tsuda M Monooxygenation mechanism by cytochrome P-450	9	1
8884	13	12573 2001 MOLECULAR AND CELLULAR BIOLOGY 21(18):6322-6331 Chen JK; Capdevila J; Harris RC Cytochrome P450 epoxygenase metabolism of arachidonic acid inhibits apoptosis	14	1
8885	4	12574 2001 MOLECULAR AND CELLULAR ENDOCRINOLOGY 178(1-2):207-214 You L; Sar M; Bartolucci E; Ploch S; Whitt M Induction of hepatic aromatase by p,p '-DDE in adult male rats	4	1
8886	1	12577 2001 MOLECULAR MICROBIOLOGY 42(3):835-849 Mey AR; Payne SM Haem utilization in Vibrio cholerae involves multiple TonB- dependent haem receptors	5	1
8887	22	12586 2001 MOLECULAR REPRODUCTION AND DEVELOPMENT 58(2):149-158 Kullman SW; Hinton DE Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes)	1	1
8888	17	12590 2001 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 492(1-2):81-90 Oda Y; Aryal P; Terashita T; Gillam EMJ; Guengerich FP; Shimada T Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O- acetyltransferase	9	1
8889	2	12591 2001 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 494(1-2):135-142 Sivikova K; Piesova E; Dianovsky J The protection of Vitamin E and selenium against carbon tetrachloride-induced genotoxicity in ovine peripheral blood lymphocytes	1	1
8890	10	12592 2001 MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 497(1-2):223-233 Hatanaka N; Yamazaki H; Oda Y; Guengerich FP; Nakajima M; Yokoi T Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P4501B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay	2	1
8891	7	12594 2001 MUTATION RESEARCH-GENOMICS 432(3-4):61-67 Chevalier D; Lo-Guidice JM; Sergent E; Allorge D; Debuysere H; Ferrari N; Libersa C; Lhermitte M; Broly F Identification of genetic variants in the human thromboxane synthase gene (CYP5A1)	3	1
8892	1	12598 2001 NATURE BIOTECHNOLOGY 19(7):673-676 Eis PS; Olson MC; Takova T; Curtis ML; Olson SM; Vener TI; Ip HS; Vedvik KL; Bartholomay CT; Allawi HT; Ma WP; Hall JG; Morin MD; Rushmore TH; Lyamichev VI; Kwiatkowski RW An invasive cleavage assay for direct quantitation of specific RNAs	11	1
8893	15	12608 2001 PATHOLOGIE BIOLOGIE 49(9):696-702 Meskar A; Plee-Gautier E; Amet Y; Berthou F; Lucas D Alcohol-xenobiotics interactions. Role of cytochrome P450 2E1.	1	1
8894	12	12613 2001 PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 70(3):127-141 Dai D; Cao Y; Falls G; Levi PE; Hodgson E; Rose RL Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p- chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide	1	1
8895	11	12621 2001 PHARMACOLOGY & TOXICOLOGY 88(1):40-44 Pons F; Calvet JH; Haag M; Raeppel V; Keravis T; Frossard N Altered expression of lung cytochrome P450 3A1 in rat after exposure to sulfur mustard	3	1
8896	4	12633 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(4):2065-2070 Helliwell CA; Chandler PM; Poole A; Dennis ES; Peacock WJ The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway	27	1
8897	20	12636 2001 PROTEIN ENGINEERING 14(10):797-802 Bell SG; Harford-Cross CF; Wong LL Engineering the CYP101 system for in vivo oxidation of unnatural substrates	2	1
8898	16	12639 2001 RESPIRATION PHYSIOLOGY 128(1):79-87 Tesfaigzi Y; Kluger M; Kozak W Clinical and cellular effects of cytochrome P-450 modulators	3	1
8899	11	12643 2001 TETRAHEDRON LETTERS 42(25):4131-4133 Falck JR; Reddy YK; Haines DC; Reddy KM; Krishna UM; Graham S; Murry B; Peterson JA Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)	2	1
8900	20	12653 2001 XENOBIOTICA 31(3):163-176 Shimada T; Watanabe J; Inoue K; Guengerich FP; Gillam EMJ Specificity of 17 beta-oestradiol and benzo[a] pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432	8	1

#	Cited nodes	Nodes / Authors	GCS	LCS
8901	17	12654 2001 XENOBIOTICA 31(4):187-204 Renwick AB; Lewis DFV; Fulford S; Surry D; Williams B; Worboys PD; Cai X; Wang RW; Price RJ; Lake BG; Evans DC Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4- trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4	4	1
8902	21	12655 2001 XENOBIOTICA 31(4):223-237 Sakuma T; Honma R; Maguchi S; Tamaki H; Nemoto N Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat	4	1
8903	48	12657 2001 XENOBIOTICA 31(8-9):499-538 Weaver RJ Assessment of drug-drug interactions concepts and approaches	6	1
8904	7	12681 2002 ANNALS OF NEUROLOGY 51(1):38-44 Taivassalo T; Abbott A; Wyrick P; Haller RG Venous oxygen levels during aerobic forearm exercise: An index of impaired oxidative metabolism in mitochondrial myopathy	3	1
8905	29	12685 2002 ANNUAL REVIEW OF PHYSIOLOGY 64():93-127 Simpson ER; Clyne C; Rubin G; Boon WC; Robertson K; Britt K; Speed C; Jones M Aromatase - A brief overview	8	1
8906	9	12686 2002 ANTICANCER RESEARCH 22(2A):863-868 Liu H; Baliga M; Baliga R Effect of cytochrome p450 2E1 inhibitors on cisplatin-induced cytotoxicity to renal proximal tubular epithelial cells	1	1
8907	5	12689 2002 APPLIED AND ENVIRONMENTAL MICROBIOLOGY 68(2):560-568 Buhler B; Witholt B; Hauer B; Schmid A Characterization and application of xylene monooxygenase for multistep biocatalysis	7	1
8908	2	12705 2002 BIOCHEMICAL JOURNAL 362():413-422 Alpert E; Gruzman A; Totary H; Kaiser N; Reich R; Sasson S A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid	2	1
8909	18	12708 2002 BIOCHEMICAL PHARMACOLOGY 63(5):889-896 Kobayashi K; Urashima K; Shimada N; Chiba K Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat	7	1
8910	16	12711 2002 BIOCHEMISTRY 41(7):2311-2321 Bureik M; Schiffler B; Hiraoka Y; Vogel F; Bernhardt R Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1	2	1
8911	2	12726 2002 BIOORGANIC & MEDICINAL CHEMISTRY 10(4):969-973 Ohta T; Nagahashi M; Hosoi S; Tsukamoto S Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor	2	1
8912	17	12731 2002 BIOSENSORS & BIOELECTRONICS 17(1-2):119-131 Tsotsou GE; Cass AEG; Gilardi G High throughput assay for cytochrome P450BM3 for screening libraries of substrates and combinatorial mutants	2	1
8913	10	12732 2002 BIOSENSORS & BIOELECTRONICS 17(3):233-238 Shumyantseva VV; Bulko TV; Schmid RD; Archakov AI Photochemical properties of a riboflavins/cytochrome P4502B4 complex	1	1
8914	5	12733 2002 BIOTECHNOLOGY AND BIOENGINEERING 80(1):33-41 Panke S; Held M; Wubbolts MG; Witholt B; Schmid A Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase	6	1
8915	44	12741 2002 CELLULAR AND MOLECULAR LIFE SCIENCES 59(5):780-789 Capdevila JH; Harris RC; Falck JR Microsomal cytochrome P450 and eicosanoid metabolism	1	1
8916	27	12762 2002 CURRENT OPINION IN BIOTECHNOLOGY 13(6):557-564 Urlacher V; Schmid RD Biotransformations using prokaryotic P450 monooxygenases	1	1
8917	10	12774 2002 DRUG METABOLISM AND DISPOSITION 30(3):314-318 Zhang WJ; Ramamoorthy Y; Kilicarslan T; Nolte H; Tyndale RF; Sellers EM Inhibition of cytochromes P450 by antifungal imidazole derivatives	3	1
8918	18	12781 2002 DRUG METABOLISM AND DISPOSITION 30(9):970-976 Hiroi T; Chow T; Imaoka S; Funae Y Catalytic specificity of CYP2D isoforms in rat and human	1	1
8919	29	12784 2002 DRUG METABOLISM AND DISPOSITION 30(12):1406-1412 Lee SJ; Buhler DR Functional properties of a rainbow trout CYP3A27 expressed by recombinant baculovirus in insect cells	1	1
8920	306	12787 2002 DRUG METABOLISM REVIEWS 34(1-2):83-448 Rendic S Summary of information on human CYP enzymes: Human P450 metabolism data	9	1
8921	19	12793 2002 ENDOCRINOLOGY 143(9):3361-3369 Moran FM; Ford JJ; Corbin CJ; Mapes SM; Njar VC; Brodie AM; Conley AJ Regulation of microsomal P450, redox partner proteins, and steroidogenesis in the developing testes of the neonatal pig	1	1
8922	11	12803 2002 EUROPEAN JOURNAL OF BIOCHEMISTRY 269(15):3838-3846 Bulow HE; Bernhardt R Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity	1	1
8923	1	12821 2002 GENE THERAPY 9(3):183-191 Zhong Z; Froh M; Wheeler MD; Smutney O; Lehmann TG; Thurman RG Viral gene delivery of superoxide dismutase attenuates experimental cholestasis-induced liver fibrosis in the rat	2	1
8924	2	12823 2002 GENOMICS 79(4):464-470 Wain HM; Bruford EA; Lovering RC; Lush MJ; Wright MW; Povey S Guidelines for human gene nomenclature	15	1
8925	20	12840 2002 JOURNAL OF APPLIED PHYSIOLOGY 93(1):330-337 Zhu DL; Zhang CY; Medhora M; Jacobs ER CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium	2	1
8926	15	12847 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(18):15647-15653 Baader M; Gnerre C; Stegeman JJ; Meyer UA Transcriptional activation of cytochrome P450CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit	2	1
8927	26	12852 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(37):33711-33719 Guengerich FP; Miller GP; Hanna IH; Sato H; Martin MV Oxidation of methoxyphenethylamines by cytochrome p450 2D6 - Analysis of rate-limiting steps	3	1
8928	7	12854 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(43):40275-40280 Rosen GM; Tsai P; Weaver J; Porasuphatana S; Roman LJ; Starkov AA; Fiskum G; Pou S The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide	7	1
8929	7	12856 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(50):48960-48964 Elmore CL; Porter TD Modification of the nucleotide cofactor-binding site of cytochrome P-450 reductase to enhance turnover with NADH in vivo	2	1
8930	14	12861 2002 JOURNAL OF CHROMATOGRAPHIC SCIENCE 40(7):397-402 Li HX; Letcher RJ A high-performance-liquid-chromatography-based method for the determination of hydroxylated testosterone metabolites formed in vitro in liver microsomes from gray seal (Halichoerus grypus)	1	1
8931	1	12862 2002 JOURNAL OF CLINICAL PERIODONTOLOGY 29(3):189-194 Battino M; Ferreiro MS; Gallardo I; Newman HN; Bullon P The antioxidant capacity of saliva	1	1
8932	2	12872 2002 JOURNAL OF LIPID RESEARCH 43(1):2-12 Edwards PA; Kast HR; Anisfeld AM BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis	50	1
8933	6	12873 2002 JOURNAL OF LIPID RESEARCH 43(3):359-364 Kliewer SA; Willson TM Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor	9	1
8934	4	12876 2002 JOURNAL OF NEUROCHEMISTRY 82(5):1252-1261 Sergeeva M; Strokin M; Wang H; Ubl JJ; Reiser G Arachidonic acid and docosahexaenoic acid suppress thrombin- evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation	2	1
8935	13	12882 2002 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 300(1):298-304 Hashizume T; Imaoka S; Mise M; Terauchi Y; Fujii T; Miyazaki H; Kamataki T; Funae Y Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal Microsomes	3	1
8936	3	12887 2002 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 82(2-3):209-216 Satoh T; Itoh S; Seki T; Itoh S; Nomura N; Yoshizawa I On the inhibitory action of 29 drugs having side effect gynecomastia on estrogen production	1	1
8937	2	12893 2002 JOURNAL OF VECTOR ECOLOGY 27(2):222-229 Chareonviriyaphap T; Rongnoparut P; Juntarumporn P Selection for pyrethroid resistance in a colony of Anopheles minimus species A, a malaria vector in Thailand	1	1
8938	10	12894 2002 KIDNEY INTERNATIONAL 62(3):868-876 Liu H; Bigler SA; Henegar JR; Baliga R Cytochrome P4502B1 mediates oxidant injury in puromycin-induced nephrotic syndrome	1	1
8939	24	12896 2002 LANCET 360(9340):1155-1162 Nebert DW; Russell DW Clinical importance of the cytochromes P450	8	1
8940	13	12911 2002 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 500(1-2):103-110 Hamzeiy H; Vahdati-Mashhadian N; Edwards HJ; Goldfarb PS Mutation analysis of the human CYP3A4 gene 5 ' regulatory region: population screening using non-radioactive SSCP	2	1
8941	4	12921 2002 ONCOLOGY REPORTS 9(2):327-329 Liu TC; Lin SF; Chen TP; Chang JG Polymorphism analysis of CYP3A5 in myeloid leukemia	1	1
8942	6	12930 2002 PLANT PHYSIOLOGY 130(1):504-513 Bancos S; Nomura T; Sato T; Molnar G; Bishop GJ; Koncz C; Yokota T; Nagy F; Szekeres M Regulation of transcript levels of the Arabidopsis cytochrome P450 genes involved in brassinosteroid biosynthesis	2	1
8943	2	12949 2002 TETRAHEDRON 58(9):1667-1671 Tsukamoto S; Cha BC; Ohta T Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity	3	1
8944	11	12957 2002 TRENDS IN ENDOCRINOLOGY AND METABOLISM 13(6):234-239 Rainey WE; Carr BR; Sasano H; Suzuki T; Mason JI Dissecting human adrenal androgen production	2	1
8945	8	12962 2002 XENOBIOTICA 32(9):739-747 Pan J; Xiang Q; Renwick AB; Price RJ; Ball SE; Kao J; Scatina JA; Lake BG Use of a quantitative real-time reverse transcription- polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices	1	1
8946	5	13000 2003 BIOCHEMISTRY 42(21):6370-6379 Wester MR; Johnson EF; Marques-Soares C; Dansette PM; Mansuy D; Stout CD Structure of a substrate complex of mammalian cytochrome P4502C5 at 2.3 angstrom resolution: Evidence for multiple substrate binding modes	1	1
8947	15	13069 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(7):5141-5147 Leys D; Mowat CG; McLean KJ; Richmond A; Chapman SK; Walkinshaw MD; Munro AW Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450	2	1
8948	17	13070 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(15):13480-13486 Henderson CJ; Otto DME; Carrie D; Magnuson MA; McLaren AW; Rosewell I; Wolf CR Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase	1	1
8949	14	13085 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(3):705-714 Bell SG; Chen XH; Sowden RJ; Xu F; Williams JN; Wong LL; Rao ZH Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450(cam)	2	1
8950	1	3 1956 BIOCHIMICA ET BIOPHYSICA ACTA 21(1):71-80 NEWTON JW; KAMEN MD CHROMATIUM CYTOCHROME	36	0
8951	0	6 1956 SCIENCE 124(3228):937-937 ESTABROOK RW LOW-TEMPERATURE STUDIES OF REDUCED HEMOPROTEINS	0	0
8952	1	8 1957 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 72(1):96-111 ELKIND MM; SUTTON H LETHAL EFFECT OF VISIBLE LIGHT ON A MUTANT STRAIN OF HAPLOID YEAST .2. ABSORPTION AND ACTION SPECTRA	17	0
8953	1	12 1957 JOURNAL OF BACTERIOLOGY 74(3):356-358 GABY WL; HADLEY C PRACTICAL LABORATORY TEST FOR THE IDENTIFICATION OF PSEUDOMONAS-AERUGINOSA	125	0
8954	1	20 1957 NATURE 179(4568):1019-1020 BOULTER D; DERBYSHIRE E; SEMMENS CS VISIBLE ABSORPTION SPECTRA OF COMMERCIAL PREPARATIONS OF CYTOCHROME-C	0	0
8955	4	23 1958 ANNUAL REVIEW OF BIOCHEMISTRY 27():455-488 NEILANDS JB BIOLOGICAL OXIDATIONS	5	0
8956	1	26 1958 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 78(1):54-65 PACKER L RESPIRATORY CARRIERS INVOLVED IN THE OXIDATION OF HYDROGEN AND LACTATE IN A FACULTATIVE AUTOTROPH	19	0
8957	3	34 1958 BULLETIN DE LA SOCIETE DE CHIMIE BIOLOGIQUE 40(12):1897-1903 CHAIX P; PETIT JF; MONIER R; ZAJDELA F LES CYTOCHROMES MICROSOMIQUES DE LA CELLULE HEPATIQUE	4	0
8958	3	44 1959 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 72(12):480-499 SINGER TP ELECTRON TRANSPORT IN CARDIAC TISSUE	10	0
8959	1	45 1959 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 75(2):472-490 BEVER AT STEROID INFLUENCES ON THE LACTIC DEHYDROGENASE-DPNH OXIDASE SYSTEM OF THE RAT UTERUS	31	0
8960	1	57 1959 COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES 249(1):192-194 SLONIMSKI P; DEFAYE J; ASSELINEAU J; LEDERER E SUR LA NATURE CHIMIQUE DES SUBSTANCES QUI STIMULENT LA FORMATION DES ENZYMES RESPIRATOIRES CHEZ LA LEVURE	19	0
8961	1	59 1959 JOURNAL OF BIOCHEMISTRY 46(11):1419-1436 ITAGAKI E; TANIGUCHI S STUDIES ON NITRATE REDUCTASE SYSTEM OF ESCHERICHIA-COLI .2. SOLUBLE NITRATE REDUCTASE SYSTEM OF AEROBICALLY GROWN CELLS IN A SYNTHETIC MEDIUM	25	0
8962	3	76 1960 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 86(2):506-511 LARDY HA; LEE YP; TAKEMORI A ENZYME RESPONSES TO THYROID HORMONES	45	0
8963	4	79 1960 ANNUAL REVIEW OF PHYSIOLOGY 22():169-190 DRUMMOND GI; BLACK EC COMPARATIVE PHYSIOLOGY - FUEL OF MUSCLE METABOLISM	41	0
8964	1	86 1960 BIOCHEMICAL JOURNAL 77():P6-P7 SCUTT PB EFFECTS OF PROLONGED OXYGENATION ON THE CYTOCHROME AND ENZYME SYSTEMS OF TORULA	1	0
8965	1	88 1960 BIOCHEMISTRY-MOSCOW 25(3):313-319 KOLOTILOVA AI THE REGULATORY SIGNIFICANCE OF THE DPN+-DPNH SYSTEM IN INTERMEDIATE CARBOHYDRATE METABOLISM	0	0
8966	2	94 1960 CANADIAN JOURNAL OF BIOCHEMISTRY AND PHYSIOLOGY 38(1):79-93 HOCHSTER RM; NOZZOLILLO CG RESPIRATORY CARRIERS AND THE NATURE OF THE REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE OXIDASE SYSTEM IN XANTHOMONAS- PHASEOLI	5	0
8967	1	95 1960 CANADIAN JOURNAL OF BIOCHEMISTRY AND PHYSIOLOGY 38(5):481-492 MADSEN NB THE OXIDATION OF SUCCINATE IN EXTRACTS OF XANTHOMONAS-PHASEOLI	4	0
8968	1	108 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(3):859-864 LENTA SMP; RIEHL SMA INFLUENCE OF METALLIC CHELATES ON THE DIPHOSPHOPYRIDINE NUCLEOTIDE OXIDASE AND DIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME- C REDUCTASE SYSTEMS	2	0
8969	2	110 1960 JOURNAL OF BIOLOGICAL CHEMISTRY 235(7):2140-2144 HACKETT DP; RICE B; SCHMID C PARTIAL DISSOCIATION OF PHOSPHORYLATION FROM OXIDATION IN PLANT MITOCHONDRIA BY RESPIRATORY CHAIN INHIBITORS	51	0
8970	0	113 1960 SCIENCE 132(3438):1492-1492 FUGMANN U; ESTABROOK RW STUDIES OF OXIDATIVE PHOSPHORYLATION USING SUBMITO-CHONDRIAL DIGITONIN PARTICLES	0	0
8971	3	115 1961 ACTA BIOCHIMICA POLONICA 8(4):437-& SZARKOWSKA L; HELLER J STUDIES ON COENZYME Q REDUCTION	4	0
8972	2	122 1961 BIOCHEMICAL JOURNAL 78(4):673-& TRUDINGER P THIOSULPHATE OXIDATION AND CYTOCHROMES IN THIOBACILLUS X .1. FRACTIONATION OF BACTERIAL EXTRACTS AND PROPERTIES OF CYTOCHROMES	62	0
8973	1	128 1961 ITALIAN JOURNAL OF BIOCHEMISTRY 10(6):454-& ARRIGONI O; ROSSI G PHOSPHORYLATION COUPLED TO SULFITE OXIDATION BY PEA MITOCHONDRIA	0	0
8974	2	132 1961 JOURNAL OF BIOLOGICAL CHEMISTRY 236(5):1585-& NYGAARD AP INDUCTION OF D(-)- AND L(+)-LACTIC CYTOCHROME C REDUCTASE IN YEAST	21	0
8975	3	134 1961 JOURNAL OF BIOLOGICAL CHEMISTRY 236(6):1850-& GRIFFITHS D; WHARTON DC STUDIES OF ELECTRON TRANSPORT SYSTEM .35. PURIFICATION AND PROPERTIES OF CYTOCHROME OXIDASE	275	0
8976	3	135 1961 JOURNAL OF BIOLOGICAL CHEMISTRY 236(11):3051-& ESTABROOK R STUDIES OF OXIDATIVE PHOSPHORYLATION WITH POTASSIUM FERRICYANIDE AS ELECTRON ACCEPTOR	94	0
8977	2	136 1961 JOURNAL OF BIOPHYSICAL AND BIOCHEMICAL CYTOLOGY 9(1):19-& ESTABROOK R; HOLOWINS.A STUDIES ON CONTENT AND ORGANIZATION OF RESPIRATORY ENZYMES OF MITOCHONDRIA	175	0
8978	2	138 1961 JOURNAL OF FOOD SCIENCE 26(3):269-& TAPPEL AL SPECTRAL MEASUREMENTS OF HEMATIN PIGMENTS OF COOKED AND CURED MEATS	5	0
8979	11	143 1961 POSTEPY BIOCHEMII 7(4):499-& GUMINSKA M ROLE OF ALPHA-GLYCEROPHOSPHATE IN CARBOHYDRATE METABOLISM OF CELLS	2	0
8980	3	147 1962 ACTA PHYSIOLOGICA ACADEMIAE SCIENTIARUM HUNGARICAE 21(4):301-& POLGAR L EFFECT OF A DETERGENT (TWEEN 80) ON DPNH CYTOCHROME C REDUCTASE ACTIVITY OF HEART MUSCLE PREPARATIONS	0	0
8981	1	160 1962 BIOCHEMICAL JOURNAL 82(1):164-& KINI MM; COOPER JR BIOCHEMISTRY OF METHANOL POISONING .4. EFFECT OF METHANOL AND ITS METABOLITES ON RETINAL METABOLISM	30	0
8982	1	171 1962 BIOCHIMICA ET BIOPHYSICA ACTA 65(3):461-& HELLE KB; KLUNGSOYR L MANNITOL 1-PHOSPHATE FORMATION IN ESCHERICHIA COLI DURING GLUCOSE UTILIZATION	19	0
8983	2	172 1962 COMPTES RENDUS DES TRAVAUX DU LABORATOIRE CARLSBERG 33():265-287 ANDRESEN N; MUSHETT CW INVESTIGATIONS ON MITOCHONDRIA IN HOMOGENATES OF THE AMOEBA CHAOS-CHAOS L	0	0
8984	2	175 1962 FEDERATION PROCEEDINGS 21(6):1070-& DORFMAN A BIOSYNTHESIS AND METABOLISM OF ACID MUCOPOLYSACCHARIDES OF CONNECTIVE TISSUES	30	0
8985	16	177 1962 ITALIAN JOURNAL OF BIOCHEMISTRY 11(1):1-& BERNARD BD RESPIRATORY CHAIN IN ANIMAL MITOCHONDRIA	0	0
8986	10	188 1962 JOURNAL OF NEUROCHEMISTRY 9(JUL):363-& KRAVITZ EA; PACKER L REACTIONS OF RESPIRATORY CHAIN IN BRAIN MITOCHONDRIAL PREPARATIONS	26	0
8987	2	189 1962 JOURNAL OF NUTRITION 76(4):375-& VANEYS J; JUDD J; HILL W; BOZIAN RC; JUDGE MA; ABRAHAMS S A REINVESTIGATION OF METHYLGLYOXAL ACCUMULATION IN THIAMINE DEFICIENCY	27	0
8988	1	195 1963 ACTA HAEMATOLOGICA 30(1):16-& WULFF HR HISTOCHEMICAL STUDIES OF LEUKOCYTES FROM AN INFLAMMATORY EXUDATE .3. DI- AND TRIPHOSPHOPYRIDINE NUCLEOTIDE - LINKED DEHYDROGENASES	12	0
8989	5	196 1963 ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA ():7-& DALLNER G STUDIES ON STRUCTURAL AND ENZYMIC ORGANIZATION OF MEMBRANOUS ELEMENTS OF LIVER MICROSOMES	4	0
8990	1	203 1963 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 14(1):79-& WU R CONTROL OF GLYCOLYSIS BY PHOSPHOFRUCTOKINASE IN SLICES OF RAT LIVER, NOVIKOFF HEPATOMA, AND ADENOCARCINOMAS	4	0
8991	1	204 1963 BIOCHEMICAL JOURNAL 89(1):P18-& HOWLAND JL PHOSPHORYLATION COUPLED TO OXIDATION OF TETRAMETHYL-P- PHENYLENEDIAMINE IN RAT-LIVER MITOCHONDRIA	0	0
8992	2	206 1963 BIOCHEMISCHE ZEITSCHRIFT 338():376-& HESS B; BRAND K UBER DIE WIRKUNG VON SCHILDDRUSENHORMON AUF DIE ATMUNGSKETTE	4	0
8993	2	208 1963 BIOCHEMISTRY-MOSCOW 28(5):801-& GELMAN NS; LUKOYANOVA MA; OPARIN AI; ZHUKOVA IG ELECTRON (HYDROGEN) TRANSPORT CHAIN IN MICROCOCCUS LYSODEIKTICUS CYTOPLASMIC MEMBRANES	2	0
8994	2	216 1963 BIOCHIMICA ET BIOPHYSICA ACTA 74(3):317-& PUMPHREY AM; REDFEARN ER INHIBITION OF SUCCINATE OXIDATION BY BARBITURATES IN TIGHTLY COUPLED MITOCHONDRIA	29	0
8995	1	225 1963 BIOCHIMICA ET BIOPHYSICA ACTA 78(4):808-& MINAKAMI S; KAKINUMA K; YOSHIKAWA H CONTROL OF RESPIRATION IN BRAIN SLICES	22	0
8996	1	226 1963 CANADIAN JOURNAL OF BIOCHEMISTRY AND PHYSIOLOGY 41(10):2205-& LUSENA CV; DASS CMS PARTICLES IN DISRUPTED RAT LIVER MITOCHONDRIA	2	0
8997	1	227 1963 COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES 256(8):1863-& GAUDEMER Y; GAUTHERON D; CYROT MO CHIMIE BIOLOGIQUE - ETUDE COMPAREE DES COMPOSANTES CYTOCHROMIQUES DE DIFFERENTES FRACTIONS SUBCELLULAIRES DE MUSCLES UTERIN ET CARDIAQUE DE PORC	0	0
8998	4	228 1963 DEVELOPMENTAL BIOLOGY 8(1):67-& HEROLD RC; BOREI H CYTOCHROME CHANGES DURING HONEY BEE FLIGHT MUSCLE DEVELOPMENT	31	0
8999	3	229 1963 EXPERIMENTAL EYE RESEARCH 2(1):48-52 GRAYMORE C; TOWLSON M LEVELS OF SOLUBLE NAD-LINKED ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE AND LACTIC ACID DEHYDROGENASE IN RAT RETINA	6	0
9000	0	230 1963 FEDERATION PROCEEDINGS 22(2):527-& ESTABROOK RW; GONZE J INFLUENCE OF PHOSPHATE POTENTIAL ON MITOCHONDRIAL PYRIDINE NUCLEOTIDE TRANSHYDROGENASE	0	0

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